Academic literature on the topic 'Transferability analysis'

This book publishes the results of the inter-regional project on "Evolutionary dynamics of agricultural enterprises and multifunctionality". Starting from the identification of a shared theoretical framework of the concept of multifunctionality, the study has developed a method for zoning the territory aimed at defining the different roles played by agriculture. The development of case studies, and meetings with stakeholders and focus groups, have made it possible to identify the weak and strong points within and outside the enterprises, with particular reference to the multifunctional components and the degree of repeatability and transferability of the experiences analysed. The result is to bring to light needs in terms of policies, tools for the valorisation of multifunctionality and strategies that enable the agricultural enterprises to commercially valorise functions not traditionally pertinent to the market.

Grounded design is a particular design-research approach applied in case studies. The approach aims to investigate social practices with the purpose of identifying and unveiling problematic aspects of that practice. In research contexts, design case studies are conducted by applying established research methods such as ethnographic field studies, participatory design, and action research. As a research approach, grounded design claims to contribute to scientific knowledge by creating a collection of documented cases that is accessible for a further comprehensive and overarching analysis. This chapter provides an example of such a study through a comparison of two design case studies in the field of civil security research, in the context of firefighting: the Landmarke project and the Koordinator project. In addition, this chapter addresses the transferability of design case studies.

Relatively few studies have investigated the strategies, policies, programmes, and projects concerning rural NEETs (namely, young people living in rural areas neither in employment nor in education or training). This special issue of Quality of Life Jour- nal is dedicated to fulfilling this gap in the literature. It contributes case studies from European Union (EU) member states. The primary purpose of this special issue is to approach and discuss the various strategies, policies, programmes, and projects appli- cable to youth rural NEETs. This special issue edition has sought to gather research papers (or critical, theoretical analysis on selected topics) covering NEETs strategies, policies, measures, programmes, and projects. These highlight the success factors and scope for transferability of good (or, how to avoid bad) practices. To that end, they examine pertinent labour market and NEET situations which can help to explain the context, reasons, and baseline for the various strategies and policy measures being implemented. They also cover assessment of NEET strategies by focusing on formal education, training and skills development, and active employment policies, in particular the role of Youth Guarantee in local/rural employment. Various other relevant factors are considered/examined, including: assessment of the NEET policy measures and results; objectives, target groups, geographical and sectoral scope in different economic activities, financial, legal and institutional frameworks; results and lessons learned, including adaptations due to crisis; domestic and international programmes, as well as numerous projects and instruments; difficulties and constraints; and, finally, assessment of the success factors and transferability of projects and strategies thereof

This chapter uses two pioneering databases to analyse the implications of the global economic crisis on international migration. The first details inflows of migrant workers of 185 nationalities to ten OECD destinations, disaggregated by skill level between 2000 and 2012. The second comprises immigration policies implemented by nineteen OECD countries between 2000 and 2012. It distinguishes between six skill-selective admission policies, six post-entry policy instruments, and three bilateral agreements. The preliminary analysis is presented against the backdrop of the crisis, which negatively affected annual inflows of highly and other skilled migrants between 2007 and 2009, although these resumed an upward trend thereafter. The starkest trends in policy terms include: the diffusion of student jobseeker visas, the relative stability in the prevalence of skill-selective policies in the wake of the crisis, a greater use of financial incentives to attract high-skilled workers, and increased employer transferability for migrants at destination.

A Treatise in Phenomenological Sociology: Object, Method, Findings, and Applications provides the first systematic approach to phenomenological sociology. Carlos Belvedere claims that phenomenological sociology is a distinctive paradigm endowed with its peculiar object, method, and stock of knowledge. He defines phenomenological sociology as a science dealing with the natural attitude of groups. When it comes to its method, he describes the actual, centenary use of the epoché, the eidetic variation, and constitutional analysis in the practice of classical and contemporary social thinkers. Finally, he collects a wealth of precious findings in the history of phenomenological sociology, which starts with the ego agens as the substratum of social life, then goes on to consider higher level strata such as pragmata, habitualities, social personalities, and institutions. He argues that social behavior can take different forms, subjective as well as objective, because it can experience a wide range of transformations thanks to specific qualities of pragmata, such as reiterableness and transferability.

This volume presents for the first time a curated selection of essays written over the last 30 years by leading design thinker and educator, Tevfik Balcioglu. With a focus on Turkish and British design, his writing examines questions of national and transnational design history and provides a critical insight into contemporary global design issues. Structured into four thematic sections with contextualizing introductions, this anthology addresses various aspects of design history, theory, education and practice. Essays look at the impact of industrialization and globalization on design cultures and highlight local and global design developments from the late 20th century to the present day. They cover reproduction techniques and technological progress in recent decades, the changing nature of mass-produced objects and the introduction of new methods, systems, shapes, forms and styles over time. Addressing issues relating to education and practice, case studies draw on Balcioglu’s work at various institutions such as Izmir University of Economics, Turkey where he established a faculty of design departments and introduced a new model of integrated programmes, and Kent University, UK where he established the BA (Hons) 3D Design course. His writing explores the nature and transferability of knowledge in the design field through critical analysis of the emergence of new degree programmes, the evolution of design education and the relationship between theory and practice.

Abstract The chapter narratively reviews the literature on economic and social outcomes of diversity from the disciplinary viewpoint of economics and management, spanning the last 30 years based on a database search followed by a bibliometric co-occurrence analysis and a focused analysis of selected research fields. The analysis is not confined to the individual or workgroup level but extends to collective outcomes on the level of the economy. The focus is on European countries, in particular, Germany, but in those cases in which research on countries around the world is more advanced, these global studies are analysed and the transferability to the European and German context is discussed. A plea is made for more multi-level and relational approaches to capturing the mechanisms through which the different types of diversity translate into economic and social outcomes.

AbstractThe objective of XXL-CT dataset segmentation is to use machine learning to virtually divide 3D volumes of complete vehicles, acquired through XXL computer tomography, into their individual components. Gathering labeled training data for this type of data is challenging. Previously, entity classification from XXL-CT data required significant manual effort involving over 120 employees for several months. This chapter shows how to develop entity segmentation procedures which significantly reduce the time from measurement to virtual analysis. The most time-consuming part of the data processing chain is currently the segmentation of individual assemblies, especially when dealing with overlapping metal sheets. We aim to demonstrate the transferability of trained networks to different XXL-CT vehicle data, taking into account the large shape variations of different metal sheets and their contact, weld or rivet points. Challenges include low data quality which is affected by acquisition and reconstruction artifacts, a dataset size of up to 1.7 terabytes, and the large number of individual instances to be segmented and their interrelationships which must be taken into account. This contribution considers three major aspects: The segmentation of CT datasets by means of neural networks, the development of solutions for the annotation of XXL-CT data, and the transferability of the trained network.

AbstractThis chapter presents the results of a study that analyzed the conditions in which it is possible to scale-up to the Urban Living Lab (ULL) approach, which was developed in large-scale social housing neighbourhoods, characterized by phenomena of social and spatial marginalization. Specifically, the aim of the study is to provide indications and tools, but also indicate challenges and critical issues to those public institutions interested in promoting and adopting, in such contexts, the ULL approach for programmes of social and/or urban regeneration. The study is based on a comparative analysis of local experimentations produced both by launching or consolidating the ULL, promoted by universities within the SoHoLab project in three European cities and by a public programme developed in the Lombardy region from 2014, which has features in common with the ULL. The study analyzed the documentation produced and thirty interviews with different stakeholders (public institutions, NGOs, social housing companies). Considering some specific topics and the important lessons learned from the local projects, the chapter deals with the theme of the transferability of labs, from a local level to a regional or national level, by an institutional lever.

Abstract Environment assisted fatigue (EAF) research in simulated reactor coolant waters has shown variable reductions in fatigue lives of laboratory specimens. Unless otherwise shown, the results are assumed transferable to the pressure boundaries of primary coolant circuits. By experiments and regression analysis determined environmental penalty factors have been adopted as means to adjust the allowable numbers of fatigue transients in reactor components. These Fen factors play a central role in transfer of EAF lab data to fatigue management and risk informed inspection at the plant. This paper reports lessons learned in experimental and analytical research of EAF aiming to understand and reliably measure Fen factors for improved transferability to the codified fatigue assessment of stainless reactor components. We have earlier reported inability to repeat the Fen factors proposed for the conservative high temperature & low-rate edge, when applying direct strain control in PWR water. This issue and ongoing research aiming to develop improved Fen models will be addressed. In addition, a thermodynamic point of view is introduced and discussed. The thermodynamic model fits poorly to the lowest Fen factors for low temperatures and/or high strain rates, which is probably also an area not well supported by experimental data but may still be relevant in PWR operation. Challenges in determining Fen factors, their transferability to plant operation and possibilities for improvements will be discussed.

The contribution subject of the construction right was re-introduced into our legal system with effect of the Act No. 89/2012 Civil Code. The right of construction, as the only institute, allows the builder to implement a construction on someone else‘s land without this construction becoming part of it, thereby breaking the principle of superficio solo cedit. This post focuses on the transferability of building rights and the possibility of limiting the transferability. In particular, the issue of negotiating a ban on transferability is currently considered a controversial issue, and this contribution aims to map the current legal regulation and, based on the analysis, present arguments aimed at resolving this issue.

The research project InDaLE (Innovative approaches to services of general interest in rural areas - learning from the experiences of other European countries for Germany) analysed innovative approaches to services of general interest in Austria, Sweden, Scotland and Germany and examined their transferability and applicability to rural areas in Germany. The analysis of experiences in other European countries regarding the adaptation of infrastructures is used for the development of innovative approaches in Germany and can offer new solutions.

Our project sought to recontextualise a popular evidence portal from the English education system to Cameroon, Chad, Niger and Nigeria. The Teaching and Learning Toolkit is a resource that summarises the global evidence for 30 different pedagogical approaches in plain language so that it can inform the decisions of school leaders in England. This paper shares the evidence synthesis for the project.

United Nations (UN) counter-terrorism (CT) policies are challenged by the emergence and resurgence of different threat profiles on the security horizon because its response framework is focused on one type of terrorism and violent extremism (T/VE) threat. As there is increasing focus on the threat of extreme right-wing T/VE in the current social and political context in the West, for example, the challenges of adaptability and transferability become apparent. This is often due to the lack of flexibility and nuance of the conversation around CT at the UN level. This same lack of consideration for complexity can be exemplified through the case of the UN Security Council’s (UNSC) Women, Peace, and Security (WPS) agenda and the subsequent application of gender mainstreaming strategies. The WPS agenda was introduced with UNSC Resolution (UNSCR) 1325 in 2000 and developed over the next two decades with the adoption of nine follow-on resolutions. The increasing visibility of the impacts of terrorist groups on women and girls, and the articulation by some groups of a strategy that specifically targeted gender equality or utilized narratives promoting the subjugation of women, created greater momentum to push for the integration of the WPS and CT agendas, reflected most significantly in UNSCR 2242. However, even with this necessary focus on the protection and empowerment of women in the peace and security space, there has often been a more limited policy conversation around the wider gender perspective and analysis needed to effectively implement gender mainstreaming strategies. There needs to be increased attention given to understanding how socio-culturally defined gender roles and expectations impact how and why every individual engages with T/VE. Additionally, research is needed on how the wider gender equality goal of gender mainstreaming strategies can be implemented This research brief examines the adaptability and transferability of the last two decades of UN CT legal and policy frameworks and architecture to the evolving threat landscape.

Background Precision public health is an effective strategy for reaching the last mile in service delivery, but is frequently hampered by its dependence on unattainable data standards and the non-transferability of the solutions designed. This paper proposes a five-part system involving 1) dynamic data governance, 2) hyperlocal community data, 3) data synthesis and analysis, 4) the design and implementation of precision interventions, and 5) correlation between community data and traditional outcome data. Recent studies of community network data have found the connectedness of communities to be positively correlated with community social and environmental outcomes. Taking advantage of hyperlocal community data is therefore a promising approach to improve community outcomes by characterizing and optimizing for greater connectivity. Methods Collection and governance of hyper-local data that is community-owned can be accomplished through such transferable systems as IRIS, a community-led referral network originally designed for multi-sector social and healthcare organizations. Using this data, communities can identify precise areas of intervention through descriptive and network analysis techniques, and design a responsive, community-led intervention. Immersive Innovation Labs, an applied learning approach, is an effective methodology for the adaptive design of innovative precision interventions. This combination of approaches can empower communities and public health professionals. Conclusion The COVID-19 pandemic revealed the impact of chronic understaffing and skills gaps, particularly at the local level. This paper aims to broaden the definition of precision public health as a response, beyond the traditional application that is dependent on big, non-contextual data sources. Reframing precision public health to a methodology dependent on community-owned, ongoing data collection allows the design of hyper-local solutions while shifting the burden of scalability to data collection technology. While challenges in implementation remain, precision is necessary to make public health and communities more responsive and effective in delivering equitable health outcomes and reaching the last mile.

The increasing prevalence of bio-based and biodegradable plastics as an alternative to traditional plastics derived from crude oil is a noteworthy trend. Polybutylene succinate (PBS), a plastic produced from succinic acid, is among the promising materials for the future. However, the production of bio-based succinic acid through biotechnical processes in controlled environments presents challenges. This process leads to increased costs and is currently not economically competitive compared to crude oil-based succinic acid production. In addition to succinic acid, levulinic acid is another monomer produced in the same process. A novel approach to the digestion of biomass has been developed to address the issue of biotechnological production of bio-based platform chemicals. This innovative process employs microwave radiation, pressure, and temperature to convert wood residues into succinic acid and levulinic acid. Various catalyst concentrations and biomass ratios were tested in a batch process, with high-pressure liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC/MS) analyses revealing the formation of succinic acid, levulinic acid, formic acid, and 2-oxoglutaric acid. The results demonstrate that microwaves combined with a metal salt catalyst can be used to produce platform chemicals from lignocellulosic biomass. To further advance the continuous production of PBS, a twin-screw extruder was modified and adapted after the successful results obtained from the batch processes. This setup enables additional experiments to evaluate the transferability of batch process results to continuous reactions, facilitating the scale-up and the economic viability of the overall PBS production process in the future.

As artistic research work in various disciplines and national contexts continues to develop, the diversity of approaches to the field becomes ever more apparent. This is to be welcomed, because it keeps alive ideas of plurality and complexity at a particular time in history when the gross oversimplifications and obfuscations of political discourses are compromising the nature of language itself, leading to what several commentators have already called ‘a post-truth’ world. In this brutal environment where ‘information’ is uncoupled from reality and validated only by how loudly and often it is voiced, the artist researcher has a responsibility that goes beyond the confines of our discipline to articulate the truth-content of his or her artistic practice. To do this, they must embrace daring and risk-taking, finding ways of communicating that flow against the current norms. In artistic research, the empathic communication of information and experience – and not merely the ‘verbally empathic’ – is a sign of research transferability, a marker for research content. But this, in some circles, is still a heretical point of view. Research, in its more traditional manifestations mistrusts empathy and individually-incarnated human experience; the researcher, although a sentient being in the world, is expected to behave dispassionately in their professional discourse, and with a distrust for insights that come primarily from instinct. For the construction of empathic systems in which to study and research, our structures still need to change. So, we need to work toward a new world (one that is still not our idea), a world that is symptomatic of what we might like artistic research to be. Risk is one of the elements that helps us to make the conceptual twist that turns subjective, reflexive experience into transpersonal, empathic communication and/or scientifically-viable modes of exchange. It gives us something to work with in engaging with debates because it means that something is at stake. To propose a space where such risks may be taken, I shall revisit Gillian Rose’s metaphor of ‘the fold’ that I analysed in the first Symposium presented by the Arne Nordheim Centre for Artistic Research (NordART) at the Norwegian Academy of Music in November 2015. I shall deepen the exploration of the process of ‘unfolding’, elaborating on my belief in its appropriateness for artistic research work; I shall further suggest that Rose’s metaphor provides a way to bridge some of the gaps of understanding that have already developed between those undertaking artistic research and those working in the more established music disciplines.

Background Lung cancer is the number one cause of cancer death worldwide.(1) It is the fifth most commonly diagnosed cancer in Australia (12,741 cases diagnosed in 2018) and the leading cause of cancer death.(2) The number of years of potential life lost to lung cancer in Australia is estimated to be 58,450, similar to that of colorectal and breast cancer combined.(3) While tobacco control strategies are most effective for disease prevention in the general population, early detection via low dose computed tomography (LDCT) screening in high-risk populations is a viable option for detecting asymptomatic disease in current (13%) and former (24%) Australian smokers.(4) The purpose of this Evidence Check review is to identify and analyse existing and emerging evidence for LDCT lung cancer screening in high-risk individuals to guide future program and policy planning. Evidence Check questions This review aimed to address the following questions: 1. What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? 2. What is the evidence of potential harms from lung cancer screening for higher-risk individuals? 3. What are the main components of recent major lung cancer screening programs or trials? 4. What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Summary of methods The authors searched the peer-reviewed literature across three databases (MEDLINE, PsycINFO and Embase) for existing systematic reviews and original studies published between 1 January 2009 and 8 August 2019. Fifteen systematic reviews (of which 8 were contemporary) and 64 original publications met the inclusion criteria set across the four questions. Key findings Question 1: What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? There is sufficient evidence from systematic reviews and meta-analyses of combined (pooled) data from screening trials (of high-risk individuals) to indicate that LDCT examination is clinically effective in reducing lung cancer mortality. In 2011, the landmark National Lung Cancer Screening Trial (NLST, a large-scale randomised controlled trial [RCT] conducted in the US) reported a 20% (95% CI 6.8% – 26.7%; P=0.004) relative reduction in mortality among long-term heavy smokers over three rounds of annual screening. High-risk eligibility criteria was defined as people aged 55–74 years with a smoking history of ≥30 pack-years (years in which a smoker has consumed 20-plus cigarettes each day) and, for former smokers, ≥30 pack-years and have quit within the past 15 years.(5) All-cause mortality was reduced by 6.7% (95% CI, 1.2% – 13.6%; P=0.02). Initial data from the second landmark RCT, the NEderlands-Leuvens Longkanker Screenings ONderzoek (known as the NELSON trial), have found an even greater reduction of 26% (95% CI, 9% – 41%) in lung cancer mortality, with full trial results yet to be published.(6, 7) Pooled analyses, including several smaller-scale European LDCT screening trials insufficiently powered in their own right, collectively demonstrate a statistically significant reduction in lung cancer mortality (RR 0.82, 95% CI 0.73–0.91).(8) Despite the reduction in all-cause mortality found in the NLST, pooled analyses of seven trials found no statistically significant difference in all-cause mortality (RR 0.95, 95% CI 0.90–1.00).(8) However, cancer-specific mortality is currently the most relevant outcome in cancer screening trials. These seven trials demonstrated a significantly greater proportion of early stage cancers in LDCT groups compared with controls (RR 2.08, 95% CI 1.43–3.03). Thus, when considering results across mortality outcomes and early stage cancers diagnosed, LDCT screening is considered to be clinically effective. Question 2: What is the evidence of potential harms from lung cancer screening for higher-risk individuals? The harms of LDCT lung cancer screening include false positive tests and the consequences of unnecessary invasive follow-up procedures for conditions that are eventually diagnosed as benign. While LDCT screening leads to an increased frequency of invasive procedures, it does not result in greater mortality soon after an invasive procedure (in trial settings when compared with the control arm).(8) Overdiagnosis, exposure to radiation, psychological distress and an impact on quality of life are other known harms. Systematic review evidence indicates the benefits of LDCT screening are likely to outweigh the harms. The potential harms are likely to be reduced as refinements are made to LDCT screening protocols through: i) the application of risk predication models (e.g. the PLCOm2012), which enable a more accurate selection of the high-risk population through the use of specific criteria (beyond age and smoking history); ii) the use of nodule management algorithms (e.g. Lung-RADS, PanCan), which assist in the diagnostic evaluation of screen-detected nodules and cancers (e.g. more precise volumetric assessment of nodules); and, iii) more judicious selection of patients for invasive procedures. Recent evidence suggests a positive LDCT result may transiently increase psychological distress but does not have long-term adverse effects on psychological distress or health-related quality of life (HRQoL). With regards to smoking cessation, there is no evidence to suggest screening participation invokes a false sense of assurance in smokers, nor a reduction in motivation to quit. The NELSON and Danish trials found no difference in smoking cessation rates between LDCT screening and control groups. Higher net cessation rates, compared with general population, suggest those who participate in screening trials may already be motivated to quit. Question 3: What are the main components of recent major lung cancer screening programs or trials? There are no systematic reviews that capture the main components of recent major lung cancer screening trials and programs. We extracted evidence from original studies and clinical guidance documents and organised this into key groups to form a concise set of components for potential implementation of a national lung cancer screening program in Australia: 1. Identifying the high-risk population: recruitment, eligibility, selection and referral 2. Educating the public, people at high risk and healthcare providers; this includes creating awareness of lung cancer, the benefits and harms of LDCT screening, and shared decision-making 3. Components necessary for health services to deliver a screening program: a. Planning phase: e.g. human resources to coordinate the program, electronic data systems that integrate medical records information and link to an established national registry b. Implementation phase: e.g. human and technological resources required to conduct LDCT examinations, interpretation of reports and communication of results to participants c. Monitoring and evaluation phase: e.g. monitoring outcomes across patients, radiological reporting, compliance with established standards and a quality assurance program 4. Data reporting and research, e.g. audit and feedback to multidisciplinary teams, reporting outcomes to enhance international research into LDCT screening 5. Incorporation of smoking cessation interventions, e.g. specific programs designed for LDCT screening or referral to existing community or hospital-based services that deliver cessation interventions. Most original studies are single-institution evaluations that contain descriptive data about the processes required to establish and implement a high-risk population-based screening program. Across all studies there is a consistent message as to the challenges and complexities of establishing LDCT screening programs to attract people at high risk who will receive the greatest benefits from participation. With regards to smoking cessation, evidence from one systematic review indicates the optimal strategy for incorporating smoking cessation interventions into a LDCT screening program is unclear. There is widespread agreement that LDCT screening attendance presents a ‘teachable moment’ for cessation advice, especially among those people who receive a positive scan result. Smoking cessation is an area of significant research investment; for instance, eight US-based clinical trials are now underway that aim to address how best to design and deliver cessation programs within large-scale LDCT screening programs.(9) Question 4: What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Assessing the value or cost-effectiveness of LDCT screening involves a complex interplay of factors including data on effectiveness and costs, and institutional context. A key input is data about the effectiveness of potential and current screening programs with respect to case detection, and the likely outcomes of treating those cases sooner (in the presence of LDCT screening) as opposed to later (in the absence of LDCT screening). Evidence about the cost-effectiveness of LDCT screening programs has been summarised in two systematic reviews. We identified a further 13 studies—five modelling studies, one discrete choice experiment and seven articles—that used a variety of methods to assess cost-effectiveness. Three modelling studies indicated LDCT screening was cost-effective in the settings of the US and Europe. Two studies—one from Australia and one from New Zealand—reported LDCT screening would not be cost-effective using NLST-like protocols. We anticipate that, following the full publication of the NELSON trial, cost-effectiveness studies will likely be updated with new data that reduce uncertainty about factors that influence modelling outcomes, including the findings of indeterminate nodules. Gaps in the evidence There is a large and accessible body of evidence as to the effectiveness (Q1) and harms (Q2) of LDCT screening for lung cancer. Nevertheless, there are significant gaps in the evidence about the program components that are required to implement an effective LDCT screening program (Q3). Questions about LDCT screening acceptability and feasibility were not explicitly included in the scope. However, as the evidence is based primarily on US programs and UK pilot studies, the relevance to the local setting requires careful consideration. The Queensland Lung Cancer Screening Study provides feasibility data about clinical aspects of LDCT screening but little about program design. The International Lung Screening Trial is still in the recruitment phase and findings are not yet available for inclusion in this Evidence Check. The Australian Population Based Screening Framework was developed to “inform decision-makers on the key issues to be considered when assessing potential screening programs in Australia”.(10) As the Framework is specific to population-based, rather than high-risk, screening programs, there is a lack of clarity about transferability of criteria. However, the Framework criteria do stipulate that a screening program must be acceptable to “important subgroups such as target participants who are from culturally and linguistically diverse backgrounds, Aboriginal and Torres Strait Islander people, people from disadvantaged groups and people with a disability”.(10) An extensive search of the literature highlighted that there is very little information about the acceptability of LDCT screening to these population groups in Australia. Yet they are part of the high-risk population.(10) There are also considerable gaps in the evidence about the cost-effectiveness of LDCT screening in different settings, including Australia. The evidence base in this area is rapidly evolving and is likely to include new data from the NELSON trial and incorporate data about the costs of targeted- and immuno-therapies as these treatments become more widely available in Australia.