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Journal articles on the topic 'Transformation, overexpression'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Ghiselli, Giancarlo, and Renato V. Iozzo. "Overexpression of Bamacan/SMC3 Causes Transformation." Journal of Biological Chemistry 275, no. 27 (2000): 20235–38. http://dx.doi.org/10.1074/jbc.c000213200.

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2

Yan, Xiaolin, Marie-France Lebel-Beaucage, Samuel Tremblay, Line Cantin, Gary S. Shaw, and Elodie Boisselier. "Optimized transformation, overexpression and purification of S100A10." BioTechniques 67, no. 5 (2019): 246–48. http://dx.doi.org/10.2144/btn-2019-0081.

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As a member of the S100 protein family, S100A10 has already been purified. However, its purity, or even yield, have often not been reported in the literature. To facilitate future biophysical experiments with S100A10, we aimed to obtain it at a purity of at least 95% in a reasonably large amount. Here, we report optimized conditions for the transformation, overexpression and purification of the protein. We obtained a purity of 97% and performed stability studies by circular dichroism. Our data confirmed that the S100A10 obtained is suitable for experiments to be performed at room temperature u

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3

Knoops, Laurent, Yohan Royer, Stefan Constantinescu, and Jean-Christophe Renauld. "Overexpression of Jak Kinases Promotes In Vitro Transformation." Blood 104, no. 11 (2004): 4325. http://dx.doi.org/10.1182/blood.v104.11.4325.4325.

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Abstract The Jak-STAT pathway is responsible for signal transduction by a large number of cytokine receptors. While this pathway is normally tightly regulated, constitutive STAT3 and STAT5 activation is frequent in hematologic malignancies and contributes to oncogenesis. We took advantage of the IL-3-dependent pro-B Ba/F3 cell line to analyze the mechanisms of constitutive STAT activation in vitro. Ba/F3 cells transfected with a mutated hIL-9R (Ba/F3 Phe116) poorly respond to IL-9. However, after selection with this cytokine, we obtained cell lines that proliferated well in IL-9. After cytokin

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4

Knoops, L., T. Hornakova, Y. Royer, S. N. Constantinescu, and J.-C. Renauld. "JAK kinases overexpression promotes in vitro cell transformation." Oncogene 27, no. 11 (2007): 1511–19. http://dx.doi.org/10.1038/sj.onc.1210800.

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5

Iwakawa, Hidekazu, Benjamin C. Carter, Brett C. Bishop, Joe Ogas, and Stanton B. Gelvin. "Perturbation of H3K27me3-Associated Epigenetic Processes Increases Agrobacterium-Mediated Transformation." Molecular Plant-Microbe Interactions® 30, no. 1 (2017): 35–44. http://dx.doi.org/10.1094/mpmi-12-16-0250-r.

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Agrobacterium-mediated transformation is a core technology for basic plant science and agricultural biotechnology. Improving transformation frequency is a major goal for plant transgenesis. We previously showed that T-DNA insertions in some histone genes decreased transformation susceptibility, whereas overexpression of several Arabidopsis H2A and H4 isoforms increased transformation. Overexpression of several histone H2B and H3 isoforms had little effect on transformation frequency. However, overexpression of histone H3-11 (HTR11) enhanced transformation. HTR11 is a unique H3 variant that lac

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6

Moiola, Cristian, Paola De Luca, Kevin Gardner, Elba Vazquez, and Adriana De Siervi. "Cyclin T1 overexpression induces malignant transformation and tumor growth." Cell Cycle 9, no. 15 (2010): 3191–98. http://dx.doi.org/10.4161/cc.9.15.12526.

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7

Ahlemann, Martin, Reinhard Zeidler, Stephan Lang, Brigitte Mack, Markus Münz, and Olivier Gires. "Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformation." Molecular Carcinogenesis 45, no. 12 (2006): 957–67. http://dx.doi.org/10.1002/mc.20269.

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8

Nagase, Toshihiko, Sumio Kawata, Hiromu Nakajima, et al. "Effect of farnesyltransferase overexpression on cell growth and transformation." International Journal of Cancer 80, no. 1 (1999): 126–33. http://dx.doi.org/10.1002/(sici)1097-0215(19990105)80:1<126::aid-ijc23>3.0.co;2-u.

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9

Grammatopoulos, G. A., E. Bell, L. Toole, A. Lumsden, and A. S. Tucker. "Homeotic transformation of branchial arch identity after Hoxa2 overexpression." Development 127, no. 24 (2000): 5355–65. http://dx.doi.org/10.1242/dev.127.24.5355.

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Overexpression of Hoxa2 in the chick first branchial arch leads to a transformation of first arch cartilages, such as Meckel's and the quadrate, into second arch elements, such as the tongue skeleton. These duplicated elements are fused to the original in a similar manner to that seen in the Hoxa2 knockout, where the reverse transformation of second to first arch morphology is observed. This confirms the role of Hoxa2 as a selector gene specifying second arch fate. When first arch neural crest alone is targeted, first arch elements are lost, but the Hoxa2-expressing crest is unable to develop

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10

Resar, Linda, Surajit Dhara, Takita Felder Sumter, et al. "STAT3: A Direct HMGA1 Gene Target Important in Lymphoid Malignancy." Blood 108, no. 11 (2006): 2222. http://dx.doi.org/10.1182/blood.v108.11.2222.2222.

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Abstract While the oncogenic properties of the high mobility group A1 (HMGA1) gene are well established, the molecular pathways that mediate transformation by HMGA1 have not been clearly defined. HMGA1 is widely overexpressed in hematologic malignancies and other human cancers. Moreover, its overexpression portends a poor prognosis in some tumors. The HMGA1 gene encodes the HMGA1a and -A1b chromatin binding proteins. We previously showed that overexpression of HMGA1a or -A1b confers a transformed phenotype in cultured, human lymphoid cells. More recently, we developed transgenic mice overexpre

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11

Stevens, C. W., W. H. Brondyk, J. A. Burgess, T. H. Manoharan, B. G. Häne, and W. E. Fahl. "Partially transformed, anchorage-independent human diploid fibroblasts result from overexpression of the c-sis oncogene: mitogenic activity of an apparent monomeric platelet-derived growth factor 2 species." Molecular and Cellular Biology 8, no. 5 (1988): 2089–96. http://dx.doi.org/10.1128/mcb.8.5.2089.

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A human c-sis cDNA in an expression vector was introduced into human diploid fibroblasts by transfection or electroporation. Fibroblast clones showing an aberrant, densely packed colony morphology were isolated and found to overexpress a 3.6-kilobase sis mRNA species and associated immunoprecipitable platelet-derived growth factor (PDGF) 2 proteins. Parallel analyses in cell clones of sis mRNA expression and colony formation in agar indicated that, above a threshold, a linear, positive correlation existed between sis overexpression and acquired anchorage independence. The sis-overexpressing ce

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12

Stevens, C. W., W. H. Brondyk, J. A. Burgess, T. H. Manoharan, B. G. Häne, and W. E. Fahl. "Partially transformed, anchorage-independent human diploid fibroblasts result from overexpression of the c-sis oncogene: mitogenic activity of an apparent monomeric platelet-derived growth factor 2 species." Molecular and Cellular Biology 8, no. 5 (1988): 2089–96. http://dx.doi.org/10.1128/mcb.8.5.2089-2096.1988.

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A human c-sis cDNA in an expression vector was introduced into human diploid fibroblasts by transfection or electroporation. Fibroblast clones showing an aberrant, densely packed colony morphology were isolated and found to overexpress a 3.6-kilobase sis mRNA species and associated immunoprecipitable platelet-derived growth factor (PDGF) 2 proteins. Parallel analyses in cell clones of sis mRNA expression and colony formation in agar indicated that, above a threshold, a linear, positive correlation existed between sis overexpression and acquired anchorage independence. The sis-overexpressing ce

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13

Flejou, J. F., F. Potet, F. Muzeau, F. Le Pelletier, F. Fekete, and D. Henin. "Overexpression of p53 protein in Barrett's syndrome with malignant transformation." Journal of Clinical Pathology 46, no. 4 (1993): 330–33. http://dx.doi.org/10.1136/jcp.46.4.330.

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14

Spruill, M. D., B. Song, W. Z. Whong, and T. Ong. "PROTO-ONCOGENE AMPLIFICATION AND OVEREXPRESSION IN CADMIUM-INDUCED CELL TRANSFORMATION." Journal of Toxicology and Environmental Health, Part A 65, no. 24 (2002): 2131–44. http://dx.doi.org/10.1080/00984100290071379.

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15

Paasinen-Sohns, Aino, Mari Kielosto, Essi Kääriäinen, et al. "C-Jun Activation-Dependent Tumorigenic Transformation Induced Paradoxically by Overexpression or Block of S-Adenosylmethionine Decarboxylase." Journal of Cell Biology 151, no. 4 (2000): 801–10. http://dx.doi.org/10.1083/jcb.151.4.801.

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All mammalian cells absolutely require polyamines (putrescine, spermidine, and spermine) for growth. Here we show that the overexpression of cDNA for S-adenosylmethionine decarboxylase (AdoMetDC), the main regulatory enzyme in the biosynthesis of higher polyamines, induces transformation of rodent fibroblasts when expressed in the sense or the antisense orientation. Both transformants were able to induce invasive tumors in nude mice. Neither transformation was associated with activation of the mitogen-activated protein kinases Erk1 and Erk2. Instead, the AdoMet DC sense, but not antisense, tra

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16

Go, Cynthia, Mary R. Schwartz, and Donald T. Donovan. "Molecular Transformation of Recurrent Respiratory Papillomatosis: Viral Typing and P53 Overexpression." Annals of Otology, Rhinology & Laryngology 112, no. 4 (2003): 298–302. http://dx.doi.org/10.1177/000348940311200402.

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Recurrent respiratory papillomatosis (RRP) is a histologically benign disease of the larynx, trachea, and bronchi. Here we report on the histologic and molecular characteristics of 7 cases of malignant transformation of RRP to squamous cell carcinoma (SCCA). The clinical histories of 7 patients with RRP who developed SCCA were carefully reviewed. Sequential biopsies were available from 5 of the 7 cases of spontaneous transformation of RRP to SCCA and were reviewed. In addition, p53 protein overexpression and human papillomavirus (HPV) typing for all cases was examined. The average age of patie

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17

Ito, Reina E., Chitose Oneyama, and Kazuhiro Aoki. "Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction." PLOS ONE 16, no. 4 (2021): e0249388. http://dx.doi.org/10.1371/journal.pone.0249388.

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Oncogene addiction is a cellular property by which cancer cells become highly dependent on the expression of oncogenes for their survival. Oncogene addiction can be exploited to design molecularly targeted drugs that kill only cancer cells by inhibiting the specific oncogenes. Genes and cell lines exhibiting oncogene addiction, as well as the mechanisms by which cell death is induced when addicted oncogenes are suppressed, have been extensively studied. However, it is still not fully understood how oncogene addiction is acquired in cancer cells. Here, we take a synthetic biology approach to in

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18

Ito, T., Y. Sasaki, and J. R. Wands. "Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases." Molecular and Cellular Biology 16, no. 3 (1996): 943–51. http://dx.doi.org/10.1128/mcb.16.3.943.

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The receptor insulin substrate 1 protein (IRS-1) is a specific substrate for insulin receptor tyrosine kinase. Expression and tyrosyl phosphorylation of IRS-1 play an important role during normal hepatocyte growth, and the gene is overexpressed in hepatocellular carcinoma tissue. We determined if IRS-1 overexpression directly contributes to cellular transformation. The human IRS-1 gene was subcloned into a mammalian expression vector driven by the cytomegalovirus early promoter. NIH 3T3 cells transiently transfected with this vector subsequently developed transformed foci. Several stably trans

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19

Song, Shengli, Rui Yan, Chunxia Wang, Jinxia Wang, and Hongmei Sun. "Improvement of a Genetic Transformation System and Preliminary Study on the Function of LpABCB21 and LpPILS7 Based on Somatic Embryogenesis in Lilium pumilum DC. Fisch." International Journal of Molecular Sciences 21, no. 18 (2020): 6784. http://dx.doi.org/10.3390/ijms21186784.

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Auxin transport mediates the asymmetric distribution of auxin that determines the fate of cell development. Agrobacterium-mediated genetic transformation is an important technical means to study gene function. Our previous study showed that the expression levels of LpABCB21 and LpPILS7 are significantly up-regulated in the somatic embryogenesis (SE) of Lilium pumilum DC. Fisch. (L. pumilum), but the functions of both genes remain unclear. Here, the genetic transformation technology previously developed by our team based on the L.pumilum system was improved, and the genetic transformation effic

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20

Sandoval, Salemiz, Christina Kraus, Er-Chieh Cho, et al. "Sox4 cooperates with CREB in myeloid transformation." Blood 120, no. 1 (2012): 155–65. http://dx.doi.org/10.1182/blood-2011-05-357418.

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Abstract The cAMP response element-binding protein (CREB) is a nuclear transcription factor that is critical for normal and neoplastic hematopoiesis. Previous studies have demonstrated that CREB is a proto-oncogene whose overexpression promotes cellular proliferation in hematopoietic cells. Transgenic mice that overexpress CREB in myeloid cells develop a myeloproliferative disease with splenomegaly and aberrant myelopoiesis. However, CREB overexpressing mice do not spontaneously develop acute myeloid leukemia. In this study, we used retroviral insertional mutagenesis to identify genes that acc

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21

Kharas, Michael G., Isharat Yusuf, Vanessa M. Scarfone, et al. "KLF4 suppresses transformation of pre-B cells by ABL oncogenes." Blood 109, no. 2 (2006): 747–55. http://dx.doi.org/10.1182/blood-2006-03-011106.

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Abstract Genes that are strongly repressed after B-cell activation are candidates for being inactivated, mutated, or repressed in B-cell malignancies. Krüppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell lineage lymphomas and leukemias. The human KLF4 gene has been identified as a tumor suppressor gene in colon and gastric cancer; in concordance with this, overexpression of KLF4 can suppress proliferation in several epithelial cell types. Here we investigate the effects of KLF4 on pro/pre–B-cell transforma

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22

Saumya, S., J. A. Aberami, and P. Deepa Sankar. "Plastid Transformation – A Greener and Cleaner Technique for Overexpression of Proteins." Research Journal of Pharmacy and Technology 12, no. 10 (2019): 5083. http://dx.doi.org/10.5958/0974-360x.2019.00881.3.

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23

Kubota, S., H. Kiyosawa, Y. Nomura, T. Yamada, and Y. Seyama. "Ornithine Decarboxylase Overexpression in Mouse 10T12 Fibroblasts: Cellular Transformation and Invasion." JNCI Journal of the National Cancer Institute 89, no. 8 (1997): 567–71. http://dx.doi.org/10.1093/jnci/89.8.567.

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24

Shigemasa, K., C. Hu, C. M. West, et al. "p16 Overexpression: A Potential Early Indicator of Transformation in Ovarian Carcinoma." Journal of the Society for Gynecologic Investigation 4, no. 2 (1997): 95–102. http://dx.doi.org/10.1177/107155769700400209.

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25

Narko, Kirsi, Ari Ristimäki, Martin MacPhee, Elizabeth Smith, Christian C. Haudenschild, and Timothy Hla. "Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression." Journal of Biological Chemistry 272, no. 34 (1997): 21455–60. http://dx.doi.org/10.1074/jbc.272.34.21455.

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26

Yokomizo-Nakano, Takako, Sho Kubota, Jie Bai, et al. "Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome." Cancer Research 80, no. 12 (2020): 2523–36. http://dx.doi.org/10.1158/0008-5472.can-19-3167.

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27

Kaul, Sunil C., Emma L. Duncan, Anna Englezou, et al. "Malignant transformation of NIH3T3 cells by overexpression of mot-2 protei." Oncogene 17, no. 7 (1998): 907–11. http://dx.doi.org/10.1038/sj.onc.1202017.

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28

Zhao, Xiangshan, Lin Lu, Nidhi Pokhriyal, et al. "Overexpression of RhoA Induces Preneoplastic Transformation of Primary Mammary Epithelial Cells." Cancer Research 69, no. 2 (2009): 483–91. http://dx.doi.org/10.1158/0008-5472.can-08-2907.

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29

Hu, Wei, Wei Li, Shenxi Xie, et al. "Kn1 gene overexpression drastically improves genetic transformation efficiencies of citrus cultivars." Plant Cell, Tissue and Organ Culture (PCTOC) 125, no. 1 (2016): 81–91. http://dx.doi.org/10.1007/s11240-015-0931-z.

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30

Woo, Janghee, Juna Lee, Young Kwang Chae, et al. "Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation." Cancer Letters 264, no. 1 (2008): 54–62. http://dx.doi.org/10.1016/j.canlet.2008.01.029.

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31

Bailey, B. A., Patricia C. Apel-Birkhold, and Douglas G. Luster. "Expression of NEP1 by Fusarium oxysporum f. sp. erythroxyli After Gene Replacement and Overexpression Using Polyethylene Glycol-Mediated Transformation." Phytopathology® 92, no. 8 (2002): 833–41. http://dx.doi.org/10.1094/phyto.2002.92.8.833.

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The necrosis inducing extracellular protein Nep1 is produced by Fusarium oxysporum f. sp. erythroxyli in liquid culture. NEP1, the Nep1 protein structural gene, was disrupted in F. oxysporum f. sp. erythroxyli isolate EN-4 by gene replacement using polyethylene glycol (PEG)-mediated transformation. NEP1 disruption was verified by polymerase chain reaction (PCR), Southern blot, and northern blot analysis. NEP1-disrupted transformants failed to produce Nep1 in liquid culture. NEP1 disruption did not affect the pathogenicity of isolate EN-4 toward Erythroxylum coca. Transformation of isolate EN-4

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32

Nori, M., U. S. Vogel, J. B. Gibbs, and M. J. Weber. "Inhibition of v-src-induced transformation by a GTPase-activating protein." Molecular and Cellular Biology 11, no. 5 (1991): 2812–18. http://dx.doi.org/10.1128/mcb.11.5.2812.

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Previous work has shown that microinjection into cells of antibodies against p21ras blocks transformation by src, suggesting that oncogenic transformation by pp60v-src is dependent on p21ras. The activity of p21ras itself is regulated by its cyclic association with GDP-GTP, where p21ras-GTP is the active form and p21ras-GDP is the inactive form. A GTPase-activating protein (GAP) mediates the inactivation of p21ras by facilitating the conversion of the active p21ras-GTP to the inactive p21ras-GDP. This predicts that overexpression of GAP would inactivate p21ras and block transformation of cells

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Nori, M., U. S. Vogel, J. B. Gibbs, and M. J. Weber. "Inhibition of v-src-induced transformation by a GTPase-activating protein." Molecular and Cellular Biology 11, no. 5 (1991): 2812–18. http://dx.doi.org/10.1128/mcb.11.5.2812-2818.1991.

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Previous work has shown that microinjection into cells of antibodies against p21ras blocks transformation by src, suggesting that oncogenic transformation by pp60v-src is dependent on p21ras. The activity of p21ras itself is regulated by its cyclic association with GDP-GTP, where p21ras-GTP is the active form and p21ras-GDP is the inactive form. A GTPase-activating protein (GAP) mediates the inactivation of p21ras by facilitating the conversion of the active p21ras-GTP to the inactive p21ras-GDP. This predicts that overexpression of GAP would inactivate p21ras and block transformation of cells

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34

Wiseman, S. M., H. Masoudi, P. Niblock, et al. "Derangement of p53 and MDM2 is involved in transformation of differentiated into anaplastic thyroid cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 5556. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5556.

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5556 Background: Anaplastic thyroid cancer arises as a consequence of tumor progression, or transformation, from pre-existing differentiated thyroid cancer. Mutation of the p53 tumor-suppressor gene represents a common event in thyroid tumor progression. MDM2 encodes a protein that complexes with p53, downregulates its function, and leads to its degradation via a ubiquitin-proteasome pathway. The objective of this study was to evaluate the change in p53 and MDM2 expression in the transformation of differentiated to anaplastic thyroid carcinoma. Methods: Of 94 cases of anaplastic thyroid cancer

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Waege, Ingrid, Georg Schmid, Sybille Thumann, Michael Thomm, and Winfried Hausner. "Shuttle Vector-Based Transformation System for Pyrococcus furiosus." Applied and Environmental Microbiology 76, no. 10 (2010): 3308–13. http://dx.doi.org/10.1128/aem.01951-09.

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ABSTRACT Pyrococcus furiosus is a model organism for analyses of molecular biology and biochemistry of archaea, but so far no useful genetic tools for this species have been described. We report here a genetic transformation system for P. furiosus based on the shuttle vector system pYS2 from Pyrococcus abyssi. In the redesigned vector, the pyrE gene from Sulfolobus was replaced as a selectable marker by the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene (HMG-CoA) conferring resistance of transformants to the antibiotic simvastatin. Use of this modified plasmid resulted in the overexpress

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Troxell, M. L., D. J. Loftus, W. J. Nelson, and J. A. Marrs. "Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation." Journal of Cell Science 114, no. 6 (2001): 1237–46. http://dx.doi.org/10.1242/jcs.114.6.1237.

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MDCK cells were engineered to reversibly express mutant E-cadherin protein with a large extracellular deletion. Mutant cadherin overexpression reduced the expression of endogenous E- and K-cadherins in MDCK cells to negligible levels, resulting in decreased cell adhesion. Despite severe impairment of the cadherin adhesion system, cells overexpressing mutant E-cadherin formed fluid-filled cysts in collagen gel cultures and responded to hepatocyte growth factor/scatter factor (HGF/SF) that induced cellular extension formation with a frequency similar to that of control cysts. However, cells were

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Fang, Xin, Ru Sun, Yuxin Hu та ін. "miRNA-182-5p, via HIF2α, contributes to arsenic carcinogenesis: evidence from human renal epithelial cells". Metallomics 10, № 11 (2018): 1607–17. http://dx.doi.org/10.1039/c8mt00251g.

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38

Hwang, Hau-Hsuan, Yin-Tzu Liu, Si-Chi Huang, et al. "Overexpression of the HspL Promotes Agrobacterium tumefaciens Virulence in Arabidopsis Under Heat Shock Conditions." Phytopathology® 105, no. 2 (2015): 160–68. http://dx.doi.org/10.1094/phyto-05-14-0133-r.

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Agrobacterium tumefaciens transfers a specific DNA fragment from the resident tumor-inducing (Ti) plasmid and effector virulence (Vir) proteins to plant cells during infection. A. tumefaciens VirB1-11 and VirD4 proteins assemble as the type IV secretion system (T4SS), which mediates transfer of the T-DNA and effector Vir protein into plant cells, thus resulting in crown gall disease in plants. Previous studies revealed that an α-crystallin-type, small heat-shock protein (HspL) is a more effective VirB8 chaperone than three other small heat-shock proteins (HspC, HspAT1, and HspAT2). Additionall

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Gordon-Kamm, Bill, Nagesh Sardesai, Maren Arling, et al. "Using Morphogenic Genes to Improve Recovery and Regeneration of Transgenic Plants." Plants 8, no. 2 (2019): 38. http://dx.doi.org/10.3390/plants8020038.

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Efficient transformation of numerous important crops remains a challenge, due predominantly to our inability to stimulate growth of transgenic cells capable of producing plants. For years, this difficulty has been partially addressed by tissue culture strategies that improve regeneration either through somatic embryogenesis or meristem formation. Identification of genes involved in these developmental processes, designated here as morphogenic genes, provides useful tools in transformation research. In species from eudicots and cereals to gymnosperms, ectopic overexpression of genes involved in

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Gaston, Sandra Marlene, James Kearns, George W. Adams, et al. "Satisfying the fatty acid demand of prostate cancer: De novo synthesis versus uptake as alternative and potentially cooperative prostate cancer phenotypes." Journal of Clinical Oncology 35, no. 6_suppl (2017): 107. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.107.

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107 Background: Malignant transformation increases cellular demand for fatty acids (FA). Many cancers show increased expression of fatty acid synthase (FASN); FASN catalyzes the de novo synthesis of the FA palmitate. While research has focused on FASN and de novo tumor FA synthesis, observations suggest that alternate mechanisms for FA acquisition are also important, including studies showing that cancer cells can be rescued from FASN inhibition by exogenous palmitate. Using a biopsy-based approach, we identified a PrCa subtype with outlier (>10 fold) overexpression of fatty acid binding pr

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Pigazzi, M., E. Manara, S. Bresolin, et al. "MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation." Haematologica 98, no. 4 (2012): 602–10. http://dx.doi.org/10.3324/haematol.2012.070664.

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Sreedhar, Annapoorna, Petra Petruska, Sumitra Miriyala, Manikandan Panchatcharam, and Yunfeng Zhao. "UCP2 overexpression enhanced glycolysis via activation of PFKFB2 during skin cell transformation." Oncotarget 8, no. 56 (2017): 95504–15. http://dx.doi.org/10.18632/oncotarget.20762.

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43

Huang, Lee-Wen, Ching-Yu Lin, Chin-Cheng Lee, Tsan-Zon Liu, and Cherng-Jye Jeng. "Overexpression of GRP78 Is Associated With Malignant Transformation in Epithelial Ovarian Tumors." Applied Immunohistochemistry & Molecular Morphology 20, no. 4 (2012): 381–85. http://dx.doi.org/10.1097/pai.0b013e3182434113.

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44

SHIGEMASA, K., C. HU, C. WEST, et al. "P 16 Overexpression: A potential early indicator of transformation in ovarian carcinoma." Journal of the Society for Gynecologic Investigation 4, no. 2 (1997): 95–102. http://dx.doi.org/10.1016/s1071-5576(97)81110-0.

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SEOMUN, Young, Jeong-a. KIM, Eunjoo H. LEE, and Choun-Ki JOO. "Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells." Biochemical Journal 358, no. 1 (2001): 41. http://dx.doi.org/10.1042/0264-6021:3580041.

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SEOMUN, Young, Jeong-a. KIM, Eunjoo H. LEE, and Choun-Ki JOO. "Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells." Biochemical Journal 358, no. 1 (2001): 41–48. http://dx.doi.org/10.1042/bj3580041.

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Abstract:

Transforming growth factor-β (TGF-β) is known to be a causative factor in pathological fibrosis and the metastasis of cancer cells, through effects on molecules of the extracellular matrix (ECM). We evaluated the influence of TGF-β1 on the gene expression of matrix metalloproteinase-2 (MMP-2) in lens epithelial cells (LECs). The results showed that TGF-β1 induced the expression of mRNA for MMP-2 in LECs. Subsequently, in order to examine the role of MMP-2, we overexpressed MMP-2 in LECs by stable transfection. The MMP-2-overexpressing LECs showed typical indicators of a myofibroblast-like cell

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Peace, Belinda E., Michael J. Hughes, Sandra J. F. Degen, and Susan E. Waltz. "Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis." Oncogene 20, no. 43 (2001): 6142–51. http://dx.doi.org/10.1038/sj.onc.1204836.

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Grandemange, Stéphanie, Pascal Seyer, Angel Carazo, et al. "Stimulation of Mitochondrial Activity by p43 Overexpression Induces Human Dermal Fibroblast Transformation." Cancer Research 65, no. 10 (2005): 4282–91. http://dx.doi.org/10.1158/0008-5472.can-04-3652.

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Singh, P., S. H. Wong, and W. Hong. "Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation." EMBO Journal 13, no. 14 (1994): 3329–38. http://dx.doi.org/10.1002/j.1460-2075.1994.tb06635.x.

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St. Clair, Daret K., X. Steven Wan, Terry D. Oberley, Kenneth E. Muse, and William H. St. Clair. "Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase." Molecular Carcinogenesis 6, no. 4 (1992): 238–42. http://dx.doi.org/10.1002/mc.2940060404.

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