Relevant bibliographies by topics / Transgender artists

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Transgender artists'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 August 2024

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Journal articles on the topic "Transgender artists"

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Evans, Elliot. "‘Wittig and Davis, Woolf and Solanas (…) simmer within me’: Reading Feminist Archives in the Queer Writing of Paul B. Preciado." Paragraph 41, no. 3 (November 2018): 285–300. http://dx.doi.org/10.3366/para.2018.0272.

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This article considers the relation between contemporary queer and transgender theory and the ‘second wave’ of feminism. Specifically, it explores the ways in which transgender theorist Paul B. Preciado's Testo Junkie: Sex, Drugs, and Biopolitics (2008) calls on feminist theorists, artists and activists of the second wave to explore transgender experience and embodiment, and to rethink gender in light of the new era of biocapitalism Preciado proposes. The article questions the way in which trajectories of feminism are conceived of (most famously through the ‘waves’ metaphor), and finally calls for a ‘scavenger methodology’ as a way to consider the formation of feminist and queer archives.
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Metzger, Cyle. "Chris Vargas's Consciousness Razing." TSQ: Transgender Studies Quarterly 7, no. 1 (February 1, 2020): 99–104. http://dx.doi.org/10.1215/23289252-7914542.

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Abstract Chris Vargas's exhibition Consciousness Razing: The Stonewall Re-Memorialization Project commemorates the fiftieth anniversary of the Stonewall rebellion by smashing pervasive mythologies that erase transgender people from most retellings of the uprising and showcasing multiple artists' proposals for monuments that at least address if not remedy this absence. Stories of gay and lesbian civil rights victories that came out of Stonewall—like the dissolution of sodomy laws, the creation of employment nondiscrimination protections, and gay marriage—all tend to trace back to the rebellion, while the critical role that transgender women, many of color, played in these advances has slipped deep into unseen corners of historical memory. This forgetting is both a symptom and cause of the continued erasure of transgender people, especially transgender women of color, from contemporary LGBT activism, community, and discourse. As a gesture of amelioration, this monument implores us to reconstruct memories of Stonewall as a way of not merely supporting celebrating contemporary trans existence but ultimately shaping trans futurity.
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Więckowska, Katarzyna. "Between and Beyond Intersex and Transgender Studies: A Review of Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, Stefan Horlacher ed., New York: Palgrave Macmillan, 2016." Anglica Wratislaviensia 56 (November 22, 2018): 321–29. http://dx.doi.org/10.19195/0301-7966.56.20.

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This review assesses Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives 2016, edited by Stefan Horlacher. Inspired by the international and interdisciplinary conference on “Transgender and Intersex in the Arts, Science and Society” that was held in 2012 in Dresden and that gathered researchers, activists, and artists working in transgender and intersex studies, the collection aims at mapping potential alliances between intersex and transgender positions, while acknowledging that the interests of transgender and intersex communities and researchers may be conflicting, if not at times contradictory. The volume adopts a non-hierarchical, multiperspectival, and interdisciplinary approach to examine a variety of issues related to gender variance and politics of recognition. Accordingly, the articles focus on those processes and texts that have played major roles in deconstructing and reconstructing gender identities during the late twentieth and early twenty-first centuries, and present analyses of legal and sociopolitical issues, theoretical perspectives and dilemmas, and literary and visual representations. The diverse topics and perspectives embrace the ethical framework of human rights, so as to inquire into the ways through which the lives and representations of marginalized groups can be improved.
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Mills, Robert. "Visibly Trans?" TSQ: Transgender Studies Quarterly 5, no. 4 (November 1, 2018): 540–64. http://dx.doi.org/10.1215/23289252-7090017.

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Abstract What happens when medieval depictions of gender-crossing saints get refracted through a transgender prism? Focusing on objects and artifacts associated with St. Eugenia of Rome, this article considers the extent to which medieval artists confronted the genderqueer potential of Eugenia's legend. Often the saint was overtly feminized, patently obscuring her road to sanctity as a gender crosser. But sometimes the crossing itself was rendered at least partially visible—notably in scenes representing the moment when, after a period living as a male monk, Eugenia is placed on trial and forced to reveal her “true” identity as a woman. Some depictions of Eugenia may therefore resonate with more recent expressions of queer and trans identity. This prompts critical reflection on the concepts of passing and trans visibility in histories of transgender.
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Khairani, Cut, Rahmad, Fitri Ernalis, Iqa Nauli, and Anjasmara. "Social Interaction of Transvestites in Bireuen Regency." Britain International of Humanities and Social Sciences (BIoHS) Journal 3, no. 1 (March 1, 2021): 217–23. http://dx.doi.org/10.33258/biohs.v3i1.394.

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The purpose of the study was to understand the social phenomenon of negative stigma and social exclusion of the existence of transvestite makeup artists through social interaction with the community in Bireuen Regency. This research uses grounded theory with data processing procedure using open coding techniques, coding a stunt and selective coding against data collected through observation, and in-depth interviews. The sample of respondents reached 20 people determined through snowball sampling techniques. The results showed that 53% of makeup artists in Bireuen Regency are transvestites who have experienced a gender identity crisis triggered by imitation actions. This form of social interaction then gets a community response in the form of dissociation, conflict with religious and socio-cultural values that develop in society. Social interaction of cultural accommodation efforts and social structures by transvestite makeup artists was not able to fuse the barriers of negative stigma attached to transgender people in Bireuen Regency.
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del Mar Pérez-Gil, María. "Undressing the Virgin Mary: Nudity and Gendered Art." Feminist Theology 25, no. 2 (January 2017): 208–21. http://dx.doi.org/10.1177/0966735016679907.

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Stripping the Virgin Mary of the myths, stories, and dogmas surrounding her is a task that has particularly appealed to a branch of feminist theology which seeks to reclaim her as a figure of female empowerment. This article aims to explore the transformation of Mary’s body into an element of resistance in the work of some contemporary artists. By depicting her nude or semi-nude, artists disrupt the gender values commonly associated with the Virgin and open up alternative possibilities of affirmative selfhood through her body. I contend that, in these works, the Virgin’s body functions as a ‘relational’ body that enters into dialogue with hitherto marginalized categories, such as the carnal, the sensual, the notion of fleshly materiality, or even the excluded sexualities of transgender people.
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Mandolini, Nicoletta, and Giorgio Busi Rizzi. "Brazilian Trans Artivism, Comics and Communities, between Digital and Print." European Comic Art 16, no. 2 (September 1, 2023): 100–124. http://dx.doi.org/10.3167/eca.2023.160205.

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Abstract This article looks at the intersection of web-based comics and print graphic memoirs authored by transgender Brazilian comics artists. Brazilian comics have in recent years opened up to internet platforms, a change that has proved particularly fruitful for LGBTQ+ artists, traditionally marginalised by the Brazilian comics industry. The article examines two case studies – those of Luiza Lemos and Alice Pereira, both authors of comics originally posted on social media and later published in print. By means of a mixed methodology that brings together semi-structured interviews with the authors and close readings, this contribution investigates the dynamics regulating the creative and publishing processes of these works, as well as the relationship that they entertain with the practice of transsexual self-narration and self-portraiture.
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Anugrah, Tirta, Muhammad Fikri Alif Ghani, Maulida Salsabila Purba, Meliastaras Surbakti, and Erwan Effendi. "Opini Publik Mengenai Maraknya Publik Figure yang Melanggar Norma di Media Sosial." Da'watuna: Journal of Communication and Islamic Broadcasting 4, no. 3 (April 1, 2024): 1408–13. http://dx.doi.org/10.47467/dawatuna.v4i3.1194.

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This research aims to describe public opinion regarding the rise of public figures who violate norms on social media. This research is a qualitative descriptive study. The research results show that a public figure is an influential person whose every behavior, attitude and activity becomes a public spectacle. So, a public figure needs to be careful in being positive in real life or on social media. There are several public figures who frequently violate norms in Indonesia, including artists, influencers and high-ranking officials. Examples of violations of norms are artists who say that they are transgender, artists who have pornography cases, artists who have bad attitudes, namely fighting through innuendo and harsh words on social media. Artists who commit sexual harassment and infidelity. Another example is an influencer who endorses a beauty product, which after investigation turns out to contain ingredients that are harmful to the skin. An example of this is high-ranking officials, namely where there are high-ranking officials who always display their luxury and wealth on social media, which turns out to be obtained from them committing corruption and bribery in their agencies. Public opinion regarding the violations of norms that occurred, namely the public's opinion to reject them by criticizing them on social media in the form of cyberbullying and cancel culture.
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Triburgo, Lorenzo, and Sarah Van Dyck. "Representational Refusal and the Embodiment of Gender Abolition." GLQ: A Journal of Lesbian and Gay Studies 28, no. 2 (April 1, 2022): 249–58. http://dx.doi.org/10.1215/10642684-9608161.

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Abstract The crisis of mass incarceration has made its way into US mainstream politics in the last five years owing in large part to the transgender activists of color who have been at the forefront of prison abolitionist movements for the last five decades. While mainstream media displays a seemingly insatiable visual appetite for trans and queer bodies, transgender women and trans-queer people—particularly those of color—continue to experience violence and criminalization at increasingly high rates. If we are to understand the prison industrial complex as an infrastructure of oppression upheld in part by the dominant narrative that people of color, poor people, and queer people are “dangerous” (to the white-capitalist-heteropatriarchy), it is critical to examine the visual language of criminalizing queerness and to further consider the work of artists grappling with efforts to shift the narrative while remaining wary of the traps of visibility.
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Lehner, Ace. "The Transgender Flipping Point: How Trans Instagrammers Flip the Script on Identity." Journal of Cultural Analysis and Social Change 7, no. 2 (December 30, 2022): 18. http://dx.doi.org/10.20897/jcasc/12759.

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Since Time magazine’s now iconic 2014 cover story featuring trans actress Laverne Cox proclaimed the contemporary moment ‘The Transgender Tipping Point’, there has been much debate about the recent proliferation of trans representations across all media sectors. Trans scholars, culture producers, artists, and activists have argued that this is not only a misconception, but it occludes the corpus of trans visual culture made by and for trans culture producers reflecting a wider diversity of trans experiences that do not readily reflect dominant cultural paradigms. Defined as a self-image made with a hand-held mobile device and shared via social media platforms, the selfie has facilitated self-imaging becoming a ubiquitous part of globally networked contemporary life. Beyond this, selfies have facilitated a diversity of image-making practices and enabled otherwise representationally marginalized constituencies to insert self-representations into visual culture. A close look at the prolific selfie practice of Black British, gender-non-conforming, trans-femme performance artist Travis Alabanza reveals their use of Instagram to be a critical intervention into contemporary culture. In self-imaging complex, expansive, and intersectional identity, Alabanza’s oeuvre produces new visual exemplars that defy stereotypes and erasures produced by dominant culture while simultaneously challenging our previously held conceptions of identity and self-portraiture. Alabanza’s work decolonizes the relationship between the subject and the portrait, encouraging viewers to consider the complex dialectical relationship between images, aesthetics, and communication about identity, performativity, gender, racialization, class, and subcultural affiliations.
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Dissertations / Theses on the topic "Transgender artists"

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Horlacher, Stefan. "Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives." Palgrave Macmillan, 2016. https://tud.qucosa.de/id/qucosa%3A37639.

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This article serves as an introduction to the phenomena of transgender and intersex, contextualizes these fields of studies, and delineates the major aims of this research anthology, that being: to take both transgender and intersex positions into account and—instead of playing them off against each other—to ask about commonalities and strategic alliances, in terms of knowledge, theory, philosophy, art, and life experience. The aim is to strike a balance between work on literature, film, photography, law, sports, and general theory, bringing together humanistic approaches with social science approaches and integrating lenses for studying gender. Further, this introduction argues that what is needed is a non-hierarchical, multi-perspective approach that endeavors to overcome the limitations of sex and gender research within the disciplines and fields of studies mentioned above by asking how transgender and intersex issues are negotiated and conceptualized from a variety of different points of view, what specific findings arise from there, and to what extent artistic and creative discourses offer their own uniquely relevant forms of knowledge and expression. The last part of this article introduces the reader to the different contributions, emphasizing how they relate to and communicate with each other.
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Fuller, Stephen. "NEW PATRIARCHIES: A TURBULENCE OF SOURCE AND SUBJECT." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3889.

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Experiencing a turbulence of source and subject in the variable inversions and supports of one source to another--the wreck of the U-352, Carpeaux’s Ugolino and his Sons, a movie poster for J.A. Bayona’s The Impossible, and Cassiopeia mythology--these four sources as sons, in sacrifice to and surviving by way of “daddy” documentation, are here refigured to reenact and critique the patriarchally recreational, monumental, cinematic, and mythological infrastructures supporting the sources of this work and thereby serving to critique the newer patriarchies to which these sources and their subjectifications here seek to cross consumptively dead end. Following three public installations, and in service to a final publication, this text hereby functions as the myth of this work.
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Books on the topic "Transgender artists"

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Ander, Álex. Veneno: De Adra a las estrellas : una biografía ilustrada. Madrid: Egales Editorial, 2021.

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King, Nia. When the white man gives you money...: Words of wisdom from queer artists of color. Oakland, California: The author, 2013.

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Antonelli, Federico J., ed. Charlotte Charlaque: Transfrau, Laienschauspielerin, "Königin der Brooklyn Heights Promenade". Berlin, Germany: Hentrich & Hentrich, 2021.

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Iasci, Cyril. Le corps qui reste: Travestir, danser, résister. Paris: Harmattan, 2014.

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Hubbell, Justin. In a word: trans: A transitioning collection of comics. Rochester, New York]: Divergent Press, 2019.

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Medeiros, Fernanda. Margem. Porto Alegre, RS: Cactus, 2017.

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Marla, Glenn. Not Otherwise Specified. [New York, NY]: The author, 2008.

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Bevacqua, María Guillermina. Deformances: Destellos de una cartografía teatral de las desobediente. Ciudad Autónoma de Buenos Aires: Editorial Libretto, 2020.

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Collective, Red Bloom Communist. Art Work During a Pandemic. [New York?]: Red Bloom Communist Collective, 2021.

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Raveau, Niki. Señales: Trans*, travesti, no binarie. Santiago de Chile: Ediciones Metales Pesados, 2019.

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Book chapters on the topic "Transgender artists"

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Halberstam, Jack. "Transgender in a Global Frame." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 165–87. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_7.

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Horlacher, Stefan. "Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 1–27. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_1.

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Frotscher, Mirjam M. "On the Intelligibility of Trans* and Intersex Characters in Contemporary British and American Fiction." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 253–75. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_10.

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Phillips, John. "Boys Don’t Cry and Tomboy: A Comparative Analysis." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 277–94. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_11.

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Whittle, Stephen, and Lewis Turner. "Queer Europe: New Normative Values for Global LGBT Law." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 29–65. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_2.

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McArdle, David. "Fear, Loathing, and Empty Gestures: UK Legislation on Sport and the Transgender Participant." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 67–81. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_3.

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Costello, Cary Gabriel. "Intersex and Trans* Communities: Commonalities and Tensions." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 83–113. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_4.

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Jansen, Sebastian. "Transgender and Intersex: Unavoidable Essentialism and the Normative Struggle for Recognition." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 115–40. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_5.

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Stritzke, Nadyne, and Elisa Scaramuzza. "Trans*, Intersex, and the Question of Pregnancy: Beyond Repronormative Reproduction." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 141–63. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_6.

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Volcano, Del LaGrace, Jay Prosser, and Eliza Steinbock. "INTER*me: An Inter-Locution on the Body in Photography." In Transgender and Intersex: Theoretical, Practical, and Artistic Perspectives, 189–224. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-349-71325-7_8.

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Conference papers on the topic "Transgender artists"

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Ferreira, Sergio Henrique, and Karla Raíza Cardoso Ribeiro. "TERAPIA GÊNICA NO TRATAMENTO DA ANEMIA FALCIFORME." In II Congresso Brasileiro de Hematologia Clínico-laboratorial On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/hematoclil/96.

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Introdução: A anemia falciforme (AF) faz parte de um grupo de distúrbios hereditários ocasionados pela alteração da produção da hemoglobina, também conhecido por hemoglobinopatia. Durante a fase desoxigenada, as hemácias contendo essa proteína mutante, a hemoglobina S (HbS) se deforma, tornando-se em força de foice. E quando passam por microvasos, formam coágulos e obstruções, causando os sintomas clínicos da doença. As terapias atuais são antálgicas, sendo a única forma de cura definitiva o transplante de medula óssea. No entanto, há uma grande dificuldade em encontrar um doador que seja aparentado e compatível com o paciente. Objetivo: Suscitar uma reflexão sobre a terapia gênica no tratamento da anemia falciforme. Métodos: Foi realizado um estudo descritivo, fundamentado em revisão de literatura, utilizando a Scientific Electronic Library Online (Scielo) e Literatura Internacional em Ciências da Saúde (PubMed/MEDLINE) a partir dos termos relacionados ao assunto principal e foco do estudo: “Terapia Gênica”, “Transplante Autólogo”, ”Anemia Falciforme”, "Lentivirus". Foram incluídos periódicos de 2017 a 2022. Utilizado como critério de exclusão, artigos fora desse período, que não tiveram acesso aberto e que não contemplaram o objetivo deste estudo. Resultados: Com a utilização de um vetor, um transgene com a sequência correta é inserido nas células-tronco hematopoiéticas obtidas do paciente, para aumentar a produção de uma hemoglobina modificada idêntica à HbA, a mais comum em adultos. Três ensaios clínicos foram realizados nos últimos anos, uma criança obteve recuperação total, os demais tiveram resultados subnormais se comparado ao primeiro caso de sucesso. As principais dificuldades foram: obter um enxerto robusto de células-tronco hematopoiéticas transduzidas, eficiência na inserção do transgene e encontrar o melhor condicionamento. Conclusão: A principal vantagem da TG é que as células possuem o máximo grau de compatibilidade. Contudo, obter um enxerto robusto e com alta eficiência na inserção do transgene se torna uma desafio. Para isso, os ensaios seguem em constantes atualizações. Assim sendo, é importante trazer uma discussão abordando esta temática que tem impacto positivo tanto no custo para os pacientes quanto numa melhor qualidade de vida para o mesmo.
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Fernandes, Narjilla Allana Conceição Macena, Túlio César Vieira de Araújo, and Maria Isabel da Conceição Dias Fernandes. "Barreiras para o cuidado ao homem transgênero durante o período gravídico-puerperal." In XIV Congresso da Sociedade Brasileira de DST - X Congresso Brasileiro de AIDS - V Congresso Latino Americano IST/HIV/AIDS. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/dst-2177-8264-202335s1267.

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Introdução: Pessoas transgênero têm uma identidade de gênero que é diferente do sexo que lhes foi designado no momento de seu nascimento. No Brasil, pouco se fala sobre o homem transgênero e o puerpério. Existe uma luta constante dessa população pelo direito à saúde. É nítido o despreparo dos profissionais de saúde e faz-se mister levar em consideração a matriz curricular dos cursos de saúde embasada na cisnormatividade, gerando constrangimento, desrespeito e um cuidado ineficaz. Objetivo: Mapear as evidências sobre as barreiras para o cuidado do homem transgênero durante o período gravídico-puerperal. Métodos: Trata-se de uma revisão integrativa de literatura, realizada em maio de 2023, com base no PRISMA-ScR, realizada nas bases de dados Cumulative Index to Nursing and Allied Health Literature (CINAHL), Excerpta Medica Database (Embase), Web of Science, Scopus (Elsevier) e National Library of Medicine (PubMed), com os descritores “Transgender Persons”, “Health”, “Pregnancy”, “Parturition” e “Postpartum Period”. A análise foi feita levando em consideração o que cada autor trazia sobre o assunto; logo após, os dados foram apresentados em eixos de discussão. Resultados: Obteve-se uma amostra final de 13 artigos. O levantamento evidenciou três eixos principais: falta de conhecimento e dificuldade dos profissionais de saúde na compreensão do gênero e pronome correto; estigmatização do homem transgênero, discriminação, homofobia e transfobia; e o enrijecimento dos profissionais na relação período gravídico-puerperal e mulher cisgênero. Conclusão: É notório que os profissionais de saúde estão desinformados quanto à temática, evidenciando a necessidade de buscar a informação para um cuidado integral e equânime.
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Dias Mendes de Souza, Larissa. "CIDADE VIBRANTE, MEMÓRIAS VIVAS: Gilda, Gênero e Dinâmicas Urbanas." In Seminario Internacional de Investigación en Urbanismo. Universitat Politècnica de Catalunya, Grup de Recerca en Urbanisme, 2024. http://dx.doi.org/10.5821/siiu.12675.

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This study examines the urban configurations of Boca Maldita in Curitiba, Brazil, in relation to Gilda: a transgender person living on the streets and involved in carnival activities, and the LGBTQIA+ movement "Boca da Noite" (Mouth of the Night). The research investigates how urban planning strategies and the city's image have contributed to gender inequality in this context, focusing on the intersection of Rua XV de Novembro and Avenida Luiz Xavier. Using an exploratory qualitative approach based on bibliographic and documentary research, the results demonstrate Gilda's influence in advocating for rights and equity for the LGBTQIA+ community and driving urban transformations. Gilda's influence inspires performances and artistic installations in "Boca Maldita"/"Boca da Noite," promoting a more inclusive society. This study highlights the importance of defending human rights, including the right to the city, and provides valuable insights for the development of effective public policies towards inclusion and equity. Keywords: Gilda, Boca Maldita, Urban dynamics, Gender inequality Este trabalho analisa as configurações urbanas da Boca Maldita, em Curitiba - PR, em relação a Gilda: uma travesti em situação de rua e carnavalesca, e ao Movimento LGBTQIA+ "Boca da Noite". A pesquisa investiga como as estratégias de urbanismo e a imagem da cidade de Curitiba contribuíram para a desigualdade de gênero nesse contexto, focando no cruzamento da Rua XV de Novembro com a Avenida Luiz Xavier. Utilizando uma abordagem qualitativa exploratória, baseada em pesquisa bibliográfica e documental, os resultados mostram a influência de Gilda na luta por direitos e equidade para a comunidade LGBTQIA+ e nas transformações urbanas. Sua influência inspira performances e instalações artísticas na "Boca Maldita"/"Boca da Noite", promovendo uma sociedade mais inclusiva. Esse estudo destaca a importância da defesa dos direitos humanos, incluindo o direito à cidade, e oferece informações relevantes para a formulação de políticas públicas efetivas em prol da inclusão e da equidade. Palavras-chave: Gilda, Boca Maldita, Dinâmicas urbanas, Desigualdade de Gênero.
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Prates, Pedro Emílio Gomes. "AVALIAÇÃO DA TERAPIA GÊNICA DO SUICÍDIO COM USO DE GENES SUICIDAS PARA O COMBATE AO CÂNCER: REVISÃO INTEGRATIVA." In II Congresso Brasileiro de Biologia Molecular On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2334.

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Introdução: Durante décadas os tratamentos quimioterápicos convencionais foram empregados no câncer devido à eficácia em matar as células tumorais. Diante disso, a terapia gênica com uso de genes suicidas surge como uma das abordagens mais inovadoras para o desenvolvimento de agentes antineoplásicos com maior seletividade tumoral. Assim, entre os genes suicidas disponíveis, a timidina quinase é investigada em vários modelos de tumor. Contudo, o uso dessa enzima apresenta limitações devido ao sistema de imunogenicidade. Recentemente, pesquisadores passaram a utilizar o sistema de gene suicida da Caspase-9 induzível, a qual apresentou resultados mais favoráveis se comparado à timidina quinase. Objetivo: Objetiva-se construir uma revisão integrativa da literatura sobre a terapia gênica do suicídio avaliando o uso de genes suicidas, sobretudo da timidina quinase e da caspase-9 induzível para o combate ao câncer. Material e Métodos: Foi realizada uma revisão integrativa de literatura por meio de uma pesquisa nos bancos de dados PubMed, Scopus e LILACS com os seguintes descritores “terapia gênica de genes suicidas”, “câncer”, “avaliação”, “timidina quinase” e “caspase-9 induzível” simultaneamente às correspondentes em inglês, em intervalo de 11 anos (2010-2021), com critérios de inclusão preestabelecidos. Para o cruzamento dos descritores, utilizou-se um protocolo com os seguintes booleanos: Gene Therapy of Suicide Gene AND Cancer AND Assessment AND Thymidine Kinase AND Inducible Caspase-9. Ao final, 4 artigos foram selecionados. Resultados: Foi selecionado 1 artigo (n = 25%) que abordava o tema da avaliação na terapia de genes suicidas. Em contrapartida, os critérios de exclusão foram estudos que não contemplavam o efeito avaliativo desses genes na terapia gênica, resumindo-se a 3 artigos selecionados (n = 75%). Com isso, observou-se que a avaliação do uso de genes suicidas ainda é uma abordagem recente, necessitando de mais estudos que contemplem essa temática. Conclusão: A avaliação da terapia gênica do suicídio pautada no uso de genes suicidas para o combate ao câncer é promissora, mesmo que recente e dos mínimos estudos publicados. Além disso, o sistema de entrega utilizando a caspase-9 induzível é mais viável do que o sistema de entrega da timidina quinase, já que esse sistema se limita à imunogenicidade do transgene viral.
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5

Miranda, Inaiê Maiala De Almeida, ANA GABRIELA DA SILVA FARIAS, VANESSA FARIA DE ALMEIDA SCHNEIDER, LARISSA DE LIMA NUNES, and PAULO EDUARDO PRZYSIEZNY. "EFICÁCIA E MECANISMO DE FUNCIONAMENTO DAS CÉLULAS CD19 CAR T NO TRATAMENTO DE CÂNCER HEMATOLÓGICO." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6313.

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Introdução: As CD19 CAR T são células reprogramadas por um transgene que codifica um receptor de antígeno quimérico (CAR) para identificar os receptores CD19 expressos em células malignas. A expansão clonal e diferenciação de T virgens ocorre a partir da ligação de MHC I associado a um antígeno e pela ligação de moléculas B7 do tipo 1 (CD80) e do tipo 2 (CD86) expresso pelas APCs aos co-receptores CD28 das células T. Na produção de células CAR T, o receptor CD19 transmutado é enviado para as células por vetor retroviral, sofrem seleção positiva na presença de IL-7, IL-21. A atividade citotóxica das células CAR T se diferenciam das TCD8+ por dispensarem a ligação com MHC I, que em células cancerígenas pode estar regulado negativamente. Os cânceres hematológicos consistem em um grupo heterogêneo de doenças agressivas que atingem as células da linhagem mielóide e linfóide, são separados em grupos de linfoma Hodgkin e não-Hodgkin, leucemia linfóide e leucemia mielóide. Objetivo: Esse estudo visa verificar a eficácia e o mecanismo de funcionamento das cd19 CAR T no tratamento de câncer hematológico, devido a importância da imunoterapia e a recente aprovação do imunoterápico dessa classe, o Kymriah® (tisagenlecleucel), pela ANVISA para cânceres hematológicos em fevereiro de 2022. Metodologia: Foi buscado no PubMed “CD19-CART cells AND immunotherapy AND hematologic cancer”. Foram encontrados 40 artigos, após análise em pares, 19 deles foram selecionados com compatibilidade com o tema. Resultados: 18 artigos apontaram que o tratamento de câncer hematológico com células CD19 CAR T é uma revolução e possui excelentes resultados contra alguns cânceres específicos. Esses trabalhos reforçam que é preciso melhorar os mecanismos de ação dessas células e ter mais estudos para confirmar sua segurança. 1 estudo trouxe os resultados como inconclusivos. Conclusão: O tratamento de câncer hematológico com células CD19 CAR T é extremamente eficaz, contudo, há importantes falhas no mecanismo de ação, como a perda do receptor CD19 e a recaída de antígeno positivo. Assim, há a necessidade de continuar as pesquisas sobre os melhores mecanismos de ação das CD19 CAR T, como associar receptores (CD22; CD137; PD-1/CD28) para aumentar a eficácia..
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