Relevant bibliographies by topics / TRANSGENIC ANIMAL

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'TRANSGENIC ANIMAL'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "TRANSGENIC ANIMAL"

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Oke, Krista B., Peter A. H. Westley, Darek T. R. Moreau, and Ian A. Fleming. "Hybridization between genetically modified Atlantic salmon and wild brown trout reveals novel ecological interactions." Proceedings of the Royal Society B: Biological Sciences 280, no. 1763 (July 22, 2013): 20131047. http://dx.doi.org/10.1098/rspb.2013.1047.

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Interspecific hybridization is a route for transgenes from genetically modified (GM) animals to invade wild populations, yet the ecological effects and potential risks that may emerge from such hybridization are unknown. Through experimental crosses, we demonstrate transmission of a growth hormone transgene via hybridization between a candidate for commercial aquaculture production, GM Atlantic salmon ( Salmo salar ) and closely related wild brown trout ( Salmo trutta ). Transgenic hybrids were viable and grew more rapidly than transgenic salmon and other non-transgenic crosses in hatchery-like conditions. In stream mesocosms designed to more closely emulate natural conditions, transgenic hybrids appeared to express competitive dominance and suppressed the growth of transgenic and non-transgenic (wild-type) salmon by 82 and 54 per cent, respectively. To the best of our knowledge, this is the first demonstration of environmental impacts of hybridization between a GM animal and a closely related species. These results provide empirical evidence of the first steps towards introgression of foreign transgenes into the genomes of new species and contribute to the growing evidence that transgenic animals have complex and context-specific interactions with wild populations. We suggest that interspecific hybridization be explicitly considered when assessing the environmental consequences should transgenic animals escape to nature.
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Santamaria, P. "Transgenic animal expressing diabetogenic Tcell receptor transgenes." Biofutur 1997, no. 167 (May 1997): 48. http://dx.doi.org/10.1016/s0294-3506(99)80369-x.

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Moore, Colin J., and T. Ben Mepham. "Transgenesis and Animal Welfare." Alternatives to Laboratory Animals 23, no. 3 (May 1995): 380–97. http://dx.doi.org/10.1177/026119299502300313.

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The two main techniques used in biomedical research for the production of transgenic animals have several implications for animal welfare in terms of the Three Rs of Russell & Burch. Some are intrinsic to the transgenic objectives, while others relate to the effects of mutations, transgene expression, associated methodologies, and husbandry or production systems. All of these actual and potential implications for animal welfare demand serious consideration within a broad ethical analysis of the technology. In the light, of the Three Rs, this may require a fundamental reappraisal of the processes by which such scientific procedures are approved.
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TSIKA, RICHARD W. "Transgenic Animal Models." Exercise and Sport Sciences Reviews 22, no. 1 (January 1994): 361–434. http://dx.doi.org/10.1249/00003677-199401000-00015.

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Towell, Jo. "Transgenic animal experiments." Nature Biotechnology 11, no. 9 (September 1993): 966. http://dx.doi.org/10.1038/nbt0993-966.

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Park, Frank. "Lentiviral vectors: are they the future of animal transgenesis?" Physiological Genomics 31, no. 2 (October 2007): 159–73. http://dx.doi.org/10.1152/physiolgenomics.00069.2007.

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Lentiviral vectors have become a promising new tool for the establishment of transgenic animals and the manipulation of the mammalian genome. While conventional microinjection-based methods for transgenesis have been successful in generating small and large transgenic animals, their relatively low transgenic efficiency has opened the door for alternative approaches, including lentiviral vectors. Lentiviral vectors are an appealing tool for transgenesis in part because of their ability to incorporate into genomic DNA with high efficiency, especially in cells that are not actively dividing. Lentiviral vector-mediated transgene expression can also be maintained for long periods of time. Recent studies have documented high efficiencies for lentiviral transgenesis, even in animal species and strains, such as NOD/ scid and C57Bl/6 mouse, that are very difficult to manipulate using the standard transgenic techniques. These advantages of the lentiviral vector system have broadened its use as a gene therapy vector to additional applications that include transgenesis and knockdown functional genetics. This review will address the components of the lentiviral vector system and recent successes in lentiviral transgenesis using both male- and female-derived pluripotent cells. The advantages and disadvantages of lentiviral transgenesis vs. other approaches to produce transgenic animals will be compared with regard to efficiency, the ability to promote persistent transgene expression, and the time necessary to generate a sufficient number of animals for phenotyping.
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Ju Kim, H., K. i. Naruse, W. S. Choi, K. S. Im, C. S. Park, and D. I. Jin. "332 ENHANCEMENT OF GROWTH PERFORMANCE IN DOUBLE TRANSGENIC MICE WITH GROWTH HORMONE RECEPTOR AND IGF-1 RECEPTOR GENES." Reproduction, Fertility and Development 17, no. 2 (2005): 317. http://dx.doi.org/10.1071/rdv17n2ab332.

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The effect of amplifying growth-related receptor signaling, through overexpression of receptors, on growth regulation in animals was examined. Transgenic mice lines were produced by DNA microinjection using the metallothionein promoter ligated to either the growth hormone receptor (GHR) or IGF-1 receptor (IGF-1R) genes (3 GHR founders and 3 IGF-1R founders). Transgenic mouse lines were estimated to contain approximately 4 to 20 copies of transgenes per cell by Southern blot analysis. Founder mice of each transgenic line transmitted transgenes into F1 and F2 pups with Mendelian ratio. Double transgenic (IGF-1R/GHR) mice were produced by the mating between nine pairs of IGF-1R and GHR hemizygous transgenic F1 mice. The transmission patterns in the 78 F2 pups produced from these matings were 20 with no transgene (25.6%), 17 with the IGF-1R gene (21.8%), 25 with the GHR gene (32.1%), and 16 with both GHR and IGF-1R genes (20.5%). The mRNA expression of transgenes using RT-PCR with the specific primers for IGF-IR and GHR genes was checked in tissues of transgenic mice. Double transgenic mice with IGF-IR and GHR genes expressed more mRNAs of transgenes than non-transgenic or single transgenic mice. Growth of double transgenic mice was fastest compared with single transgenic mice containing IGF-1R or GHR genes. And GHR transgenic mice grew faster than IGF-1R transgenic mice. When body weights of 15 transgenic mice for each transgenic line were measured at 4, 10, and 14 weeks after birth, double transgenic mice were significantly heavier compared with non-transgenic control mice at each stage (24 to 30% heavier in double transgenic mice; 15 to 20% heavier in single transgenic mice, P < 0.05). These results suggest that overexpression of growth-related receptor genes could promote the growth of transgenic animals with an additive effect.
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de Groot, Dorien M., Anton J. M. Coenen, Albert Verhofstad, François van Herp, and Gerard J. M. Martens. "In Vivo Induction of Glial Cell Proliferation and Axonal Outgrowth and Myelination by Brain-Derived Neurotrophic Factor." Molecular Endocrinology 20, no. 11 (November 1, 2006): 2987–98. http://dx.doi.org/10.1210/me.2006-0168.

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Abstract Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of neuronal cell survival and differentiation factors but is thought to be involved in neuronal cell proliferation and myelination as well. To explore the role of BDNF in vivo, we employed the intermediate pituitary melanotrope cells of the amphibian Xenopus laevis as a model system. These cells mediate background adaptation of the animal by producing high levels of the prohormone proopiomelanocortin (POMC) when the animal is black adapted. We used stable X. transgenesis in combination with the POMC gene promoter to generate transgenic frogs overexpressing BDNF specifically and physiologically inducible in the melanotrope cells. Intriguingly, an approximately 25-fold overexpression of BDNF resulted in hyperplastic glial cells and myelinated axons infiltrating the pituitary, whereby the transgenic melanotrope cells became located dispersed among the induced tissue. The infiltrating glial cells and axons originated from both peripheral and central nervous system sources. The formation of the phenotype started around tadpole stage 50 and was induced by placing white-adapted transgenics on a black background, i.e. after activation of transgene expression. The severity of the phenotype depended on the level of transgene expression, because the intermediate pituitaries from transgenic animals raised on a white background or from transgenics with only an approximately 5-fold BDNF overexpression were essentially not affected. In conclusion, we show in a physiological context that, besides its classical role as neuronal cell survival and differentiation factor, in vivo BDNF can also induce glial cell proliferation as well as axonal outgrowth and myelination.
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Robl, J. M., Z. Wang, P. Kasinathan, and Y. Kuroiwa. "Transgenic animal production and animal biotechnology." Theriogenology 67, no. 1 (January 2007): 127–33. http://dx.doi.org/10.1016/j.theriogenology.2006.09.034.

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Wigley, P., C. Becker, J. Beltrame, T. Blake, L. Crocker, S. Harrison, I. Lyons, et al. "Site-specific transgene insertion: an approach." Reproduction, Fertility and Development 6, no. 5 (1994): 585. http://dx.doi.org/10.1071/rd9940585.

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Methods to improve the production of transgenic animals are being developed. Conventional transgenesis, involving microinjection of DNA into fertilized eggs, has a number of limitations. These result from the inability to control both the site of transgene insertion and the number of gene copies inserted. The approach described seeks to overcome these problems and to allow single copy insertion of transgenes into a defined site in animal genomes. The method involves the use of embryonic stem cells, gene targeting and the FLP recombinase system.
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Dissertations / Theses on the topic "TRANSGENIC ANIMAL"

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Gilder, Michael Frederick James. "Molecular investigations in animal models of Huntington's disease." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.

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Saijo(Kim), Misa. "Generation of transgenic animal model of hyperthyroid Graves' disease." Kyoto University, 2004. http://hdl.handle.net/2433/147457.

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Bando, Mika. "Studies on pathophysiological significance of intraislet ghrelin using transgenic animal model." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188712.

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Abilgos, Ramos Riza. "Folate profiling in wild and transgenic rice." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12870/.

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Quantitative profiling of mono- and polyglutamyl folates in rice was achieved using the microbiological assay (MA) and a newly developed liquid chromatography tandem mass spectrometry (LC-MS/MS) method. MA was used to screen 51 rice cultivars for their total folate content and LC-MS/MS was employed to measure naturally occurring mono- and polyglutamated forms of the vitamin in wild type, FPGS Os03g02030 knockout and transgenic lines with overexpressed FPGS genes and with folate binding protein from cow’s milk (cFBP) and rat’s liver (GNMT). Natural variation among rice cultivars in terms of total folate content was measured using MA screening and the validated LC-MS/MS technique of simultaneous profiling of mono- and polyglutamated folates through MeOHAA/PO4 extraction revealed that the naturally-occurring species in wild type rice are 5-CH3-H4PteGlu, 5/10-CHO-H4PteGlu, 5-CH3-H4PteGlu4, 5-CH3-H4PteGlu5 and 5/10-CHO-PteGlu5. There was a general decrease in these folate forms in the FPGS Os03g02030 knockout rice line while a dramatic increase was observed in overexpressed FPGS, cFBP and GNMT compared to Nipponbare in terms of 5-CH3-H4PteGlu4, 5/10-CHO-H4Pteglu5, 5-CH3-H4PteGlu6, and 5/10-CHO-H4Pteglu6 levels, resulting in a 2.5 to 8.8-fold increase in the total folate pool in the unpolished grains of rice. This study looked at the role of the two FPGS genes (Os03g02030 and Os10g35940) found in rice and the possible effect of introducing folate binding proteins (cFBP and GNMT) in terms of the overall folate profile in rice which can be exploited in breeding programmes designed to enhance folate content in staple crops like rice.
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May, Leigh A. "The production and characterisation of transgenic disease models for retinal ocular neovascularisation." University of Western Australia. Centre for Ophthalmology and Visual Science, 2004. http://theses.library.uwa.edu.au/adt-WU2006.0047.

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[Truncated abstract] One of the barriers to understanding and preventing proliferative diabetic retinopathy in humans has been the lack of an appropriate animal model. Historically dog, rat and mouse models of diabetic retinopathy have been studied but none of these exhibit the later changes of proliferative diabetic retinopathy. Animals can be rendered diabetic by surgical pancreatectomy or the use of chemicals such as allozan or streptozotocin or by feeding of a high galactose diet. Alternatively, spontaneous rodent models of diabetes have been examined such as the BB rat, KK mouse or NOD mouse. However, in each case the retinal vascular changes observed are those of early nonproliferative diabetic retinopathy comprising at most saccular microaneurysms, increased thickness of the capillary basement membrane, acellular capillaries and pericyte ghosts. … Fluorecein angiography of this transgenic line clearly demonstrates the presence of leaky new vessels, by the appearance of leakage spots scattered throughout the retina from 1 month of age. These mice constitute a valuable model of diabetic retinopathy. Neovascularization in this animal model is induced by VEGF as in human diabetic retinopathy. The source of VEGF in human diabetic retinopathy is the ischemic inner retina. In this transgenic model the source of VEGF are the photoreceptor cells, which are situated just underneath the inner retina. The neovascularization is not dependent on a particular developmental stage and there is no spontaneous regression of new vessels. Thus any results generated in this model are highly relevant to human diabetic retinopathy.
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Wilbert, Friederike Kristin [Verfasser]. "Development of a transgenic animal model for measurement of intra-cellular ATP / Friederike Kristin Wilbert." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148426116/34.

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Ravache, Thaís Terpins, Renata Simões, and Marcelo Demarchi Goissis. "Geração de animais transgênicos por inoculação de vetor viral em meio de cultura de óvulos." reponame:Repositório Institucional da UFABC, 2014.

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Orientador: Prof. Dr. Marcelo Augusto Christoffolete
Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biotecnociência, 2014.
Desde o século XV, animais fazem parte da rotina na área da pesquisa, principalmente para estudos de doenças, e hoje em dia o modelo animal mais utilizado para estes estudos é o camundongo, tendo uma participação em mais de 90% das pesquisas em todo o mundo, sendo considerado como uma primeira via para definir funções de genes em mamíferos. Os camundongos são considerados os principais modelos nas técnicas de transgenia animal, porém estas técnicas ainda estão em desenvolvimento, uma vez que as metodologias hoje utilizadas para a geração de animais transgênicos ainda se encontram com uma taxa de sucesso considerada baixa e são dispendiosas, necessitando de muitas etapas. Uma das dificuldades é o contato com a membrana do óvulo devido a zona pelúcida, que é considerada uma barreira física. Vetores virais estão em evidência nas técnicas de transgenia animal, sendo o lentivírus o mais utilizado. Portanto, o objetivo deste projeto é estabelecer um protocolo para a integração de DNA exógeno em óvulos por infecção lentiviral, anteriormente a fertilização in vitro juntamente com a técnica de dissecção parcial da zona pelúcida. Como vetor foi utilizado um lentivírus com GFP em sua construção. Para ocorrer a fertilização in vitro, foram feitas coletas de óvulos em camundongos fêmeas da linhagem C57BL/6, tratadas com injeções hormonais, e coletas de espermatozoides em machos desta mesma linhagem. Os óvulos obtidos foram divididos em grupos controle e com dissecção parcial da zona pelúcida, e estes foram subdivididos em grupos com e sem infecção lentiviral. Entre os grupos houve variação de 20% a 56,25% de embriões em estágio de duas células, e em alguns grupos foi possível alcançar o estágio de blastocisto eclodido. Porém não foi possível visualizar a emissão de fluorescência para confirmar a infecção lentiviral. Em conclusão as metodologias utilizadas tanto para a fertilização in vitro como para a dissecção parcial da zona pelúcida foram de sucesso. Porém a integração do DNA exógeno mostrou resultados não conclusivos, necessitando de estudos futuros.
Since the XV century, animals are used routinely in research, mainly for diseases studies, and nowadays the most used animal model is the mouse, which one has more than 90% of participation in researches around the world and it is considered the first track to define gene function in mammals. Mouse is the main model in transgenic techniques, however the methods available to generate transgenic animals still have a considerable low rate, and also it is expensive, requiring many degrees. An ordinary issue is the contact with the membrane of oocyte due zona pellucida that is considered a physical barrier. In transgenic animals technique, it is in evidence the utilization of viral vectors, and the most used are the lentiviruses. Therefore, the objective of this project is to establish a protocol for the integration of exogenous DNA by lentiviral infection into oocytes, before the in vitro fertilization, using the technique of partial dissection of the zona pellucida. It was used as a vector a lentivirus with GFP in your construction. For in vitro fertilization, were collected oocytes from C57Bl/6 mice, treated with hormones, and sperm from males of the same strain. The obtained oocytes were divided in control group and partial dissection of the zona pellucida group, and then subdivided in groups with and without lentiviral infection. Between the groups, was achieved 20% to 56,25% of two cells stage embryo, and hatched blastocysts stage were obtained at some groups. Therefore it was not possible to visualize florescence emission to confirm the lentiviral infection. In conclusion we have a practicable protocol for in vitro fertilization and partial dissection of the zona pellucida, reaching blastocysts stages in two groups. However the integration of exogenous DNA results were inconclusive, requiring further studies.
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Regensburger, Martin [Verfasser], and Beate [Akademischer Betreuer] Winner. "Adult neurogenesis in transgenic animal models of DYT1 primary torsion dystonia / Martin Regensburger. Betreuer: Beate Winner." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1022872877/34.

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Tsang, Kwok-yeung, and 曾國揚. "Molecular pathogenesis of abnormal chondrocyte differentiation in a transgenic mouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B4501551X.

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Tang, Zhi. "Mass spectrometry-based metabolomics to unravel alterations in hepatic cell lines and transgenic mouse model of Alzheimer's disease." HKBU Institutional Repository, 2016. http://repository.hkbu.edu.hk/etd_oa/269.

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Chapter 5 reported the study to assess whether the urinary metabolic alterations linked to early pathophysiological changes in the TgCRND8 mouse model of AD. An unbiased metabolomics approach using high resolution Orbitrap mass spectrometry coupled with hydrophilic interaction liquid chromatography was conducted to uncover the metabolic alterations as a relevant readout of biochemical activity that implicated in the pathogenesis and progression of AD in the TgCRND8 mice. A total of 73 differential metabolites of urine sample sets was identified in 12-week and 18-week transgenic mice compared to wild-type littermates, covering perturbations of aromatic amino acids metabolism, TCA cycle and one-carbon metabolism. Of particular interest, divergent tryptophan metabolism, such as up-regulation of serotonin pathway while down-regulation of kynurenine pathway, was observed. The accumulation of both N-acetylvanilalanine and 3-methoxytyrosine indicated the aromatic L-amino acid decarboxylase deficiency. The microbial metabolites derived from tryptophan metabolism and drug-like phase II metabolic response via the glycine conjugation reactions were also highlighted, indicating that genetic modification in mouse brain not only alters genotype but also disturbs gut microbiome. Together, our study demonstrated that the integrative approach employing mass spectrometry-based metabolomics and a transgenic mouse model for AD might provide new insights into the metabolic phenotypes of AD with a noninvasive approach.;For cancer metabolism research, much effort has been focused on development of ultrahigh performance liquid chromatography triple quadrupole mass spectrometry (UPLC-MS/MS)-based targeted metabolomics method and its emerging applications in exploiting oncogene-induced metabolic alterations. To achieve our goal, more than one hundred intermediate and/or metabolite were selected and broadly categorized into cationic species and anionic species. Tandem mass spectrometric conditions were extensively optimized for each analyte by using energy-resolved collision-induced dissociation. Two crucial operating parameters of tandem mass spectrometry, namely, cone voltage and collision energy were finely tuned to get the highest signal response of the parent ion and fragment ions. Multiple reaction monitoring (MRM) transitions were created for each targeted compound, providing foundation for MRM-based assays. Meanwhile, to enhance the retention and separation of the water-soluble metabolites on reversed-phase C18 column, hydrophobic ion-pairing interactions separation (HIPS) strategies were proposed and established via complementary use of two ion-pairing reagents, heptafluorobutyric acid and tributylamine, for the cationic species and anionic species, respectively. The HIPS strategies led to efficient retention and resolution of polar intermediates/metabolites, covering the majority of components involved in central carbon metabolism and amino acid metabolism. Even isomeric pairs, like citrate-isocitrate and leucine-isoleucine, were almost baseline resolved. The performance evaluation of the developed UPLC MRM-based assays showed that nanomolar levels of limit of quantification were achieved. The developed methods enabled quantitative analysis of central carbon metabolism in mammalian cells. The altered metabolism induced by the overexpression of the oncogene EIF5A2 in human normal liver cell line LO2 was studied. We found that the altered aerobic glycolysis and pentose phosphate pathway dysregulated the tricarboxylic acid (TCA) cycle and amino acid imbalances presented as distinct metabolic features in EIF5A2 overexpressed LO2 cells.;In chapter 3, we performed quantitative analysis of central carbon metabolism and amino acid metabolism via the established UPLC-MRM-based metabolomics, which was combined with pharmacological inhibition of the catalytic enzymes, O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) and β-N-acetylglucosaminidase (O-GlcNAcase, OGA) in order to uncover the contribution of protein (including the glycolytic enzymes) O-GlcNAc modification to metabolic alterations in cancer cells. We found that OGA inhibition led to decreased levels of intermediates in both glycolysis and TCA cycle, but increased level of pentose phosphate pathway. Interestingly, the opposite phenotypes were obtained in OGT inhibition, i.e., the increased levels of glycolysis and TCA cycle were observed. Our data suggested that O-GlcNAc modification could direct switches of glucose metabolism through coordinated glycolysis and TCA cycle pathways in HCC cell line.;In Chapter 4, an improved UPLC-MS/MS method for accurate and rapid assessment of the content and redox state of coenzyme Q10 (CoQ10) and the crucial component of electron transport chain (ETC) was described. Non-aqueous reversed phase liquid chromatography on a C18 column was hyphenated with tandem mass spectrometry working in the electrospray ionization positive MRM mode, with methanol serving dual roles as sample preparation solvent and mobile phase. This rapid extractive and analytical method could avoid artificial auto-oxidation of reduced form of CoQ10, enabling the native redox state assessment. To demonstrate the utility of the developed method, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed mice liver tissue were analyzed, revealing the down-regulated mitochondrial ETC in TCDD exposed mice group.;This thesis research concentrates on the development and applications of mass spectrometry-based metabolomics to elucidate biochemical alterations involved in basic research models for two common human diseases: mammalian cell culture model of hepatocellular carcinoma (HCC) and transgenic mouse model of Alzheimer's disease (AD). Two major approaches were developed: (1) targeted quantitative metabolomics for elucidation of altered cancer metabolism in human liver cell lines caused by the overexpression of the oncogene eukaryotic translation initiation factor 5A2 (EIF5A2) and O-Linked β-N-acetylglucosamine (O-GlcNAc) modification; (2) non-targeted metabolite profiling for early discovery of potential non-invasive urinary metabolite markers in the transgenic mouse model TgCRND8 of AD.
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Books on the topic "TRANSGENIC ANIMAL"

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Flachowsky, G., ed. Animal nutrition with transgenic plants. Wallingford: CABI, 2013. http://dx.doi.org/10.1079/9781780641768.0000.

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Transgenic Animal Research Workshop (1988 Iowa State University). Proceedings of the Transgenic Animal Research Workshop. Ames, Iowa, USA: Technology and Social Change Program, Iowa State University, 1989.

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Chaffee, Chet. Transgenics: Changing the face of animal genetics. Menlo Park, CA (333 Ravenswood Ave., Menlo Park 94025-3476): SRI International, Business Intelligence Program, 1989.

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Toransujenikku dōbutsu no kaihatsu: Development of transgenic animals. Tōkyō: Shīemushī, 2001.

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Health), Symposium on Transgenic Technology in Medicine and Agriculture (1988 National Institutes of. Transgenic animals: Proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture. Boston: Butterworth-Heinemann, 1991.

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Müller, Albrecht. Ethische Aspekte der Erzeugung und Haltung transgenic Nutztiere. Stuttgart: F. Enke, 1995.

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Buehr, Mia. Genetically modified animals: Perspectives in development and use. København: Ministry of the Environment and Energy, Danish Environmental Protection Agency, 1994.

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Mutant animals: Crazy creatures altered by science. North Mankato, Minnesota: Capstone Press, a Capstone imprint, 2014.

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What's wrong with my mouse?: Behavioral phenotyping of transgenic and knockout mice. 2nd ed. Hoboken, NJ: Wiley-Interscience, 2007.

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Health), Symposium on Transgenic Animal Models in Biomedical Research (1991 National Institutes of. Transgenic animal models in biomedical research: Proceedings of a Symposium held at the National Institutes of Health, Bethesda, Maryland, November 4-5, 1991. Washington, D.C: Armed Forces Institute of Pathology, 1992.

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Book chapters on the topic "TRANSGENIC ANIMAL"

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Turiault, Marc, Caroline Cohen, Guy Griebel, David E. Nichols, Britta Hahn, Gary Remington, Ronald F. Mucha, et al. "Transgenic Animal." In Encyclopedia of Psychopharmacology, 1331. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3635.

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Jha, Abhimanyu Kumar. "Transgenic." In Encyclopedia of Animal Cognition and Behavior, 1–2. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47829-6_2050-1.

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Singh, Birbal, Gorakh Mal, Sanjeev K. Gautam, and Manishi Mukesh. "Transgenic Fish." In Advances in Animal Biotechnology, 291–300. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21309-1_26.

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Laible, Götz. "Production of Transgenic Livestock: Overview of Transgenic Technologies." In Animal Biotechnology 2, 95–121. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92348-2_6.

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D’Silva, Joyce. "Campaigning against transgenic technology." In Animal Biotechnology and Ethics, 92–102. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5783-8_7.

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Sahara, Naruhiko, Heather Melrose, Simon D'alton, and Jada Lewis. "Transgenic Animal Models of Proteinopathies." In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, 26–36. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444341256.ch7.

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"Transgenic Animal." In Encyclopedia of Cancer, 3763. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_5920.

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Knudsen, Thomas B., and Judith A. Wubah. "Transgenic Animal Models." In Handbook of Developmental Neurotoxicology, 209–21. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012648860-9.50014-5.

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Houdebine, Louis-Marie. "Transgenic Animal Production." In Biotechnology for Sustainable Agriculture, 141–84. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-812160-3.00005-2.

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"Transgenic animal models." In Pharmaceutical Design And Development, 240–55. CRC Press, 1994. http://dx.doi.org/10.1201/b12597-12.

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Conference papers on the topic "TRANSGENIC ANIMAL"

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Matovu, Jacob, and Ahmet Alçiçek. "Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.011.

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The fate of transgenic DNA (tDNA) and protein from feed derived from Genetically Modified organisms (GMOs) in animals has been a major issue since their commercialization in 1996. Several studies have investigated the risks of horizontal gene transfer (HGT) of tDNA and protein to bacteria or animal cells/tissues, but some of the reported data are controversial. Previous reports showed that tDNA fragments or proteins derived from GM plants could not be detected in tissues, fluids, or edible products from livestock. Other researchers have shown that there is a possibility of small fragments entering animal tissues, fluids and organs. This motivated us to update our knowledge about these concerns. Therefore, this review aimed to evaluate the probable transfer and accumulation of tDNA/proteins from transgenic feeds in animal samples (ruminant and non-ruminant) by evaluating the available experimental studies published scientifically. This study found that the tDNA/protein is not completely degraded during feed processing and digestion in Gastro-Intestinal Tract (GIT). In large ruminants (cattle), tDNA fragments/proteins were detected in GIT digesta, rumen fluid, and faeces. In small ruminants (goats), traces of tDNA/proteins were detected in GIT digesta, blood, milk, liver, kidney, heart and muscle. In pigs, they were detected in blood, spleen, liver, kidney, and GIT digesta. In poultry, traces were detected in blood, liver and GIT digesta but not in meat and eggs. Notwithstanding some studies that have shown transfer of tDNA/protein fragments in animal samples, we cannot rely on these few studies to give general evidence for transfer into tissues/fluids and organs of farm animals. However, this study clearly shows that transfer is possible. Therefore, intensive and authentic research should be conducted on GM plants before they are approved for commercial use, investigating issues such as the fate of tDNA or proteins and the effects of feeding GM feed to livestock.
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Cruz-Monserrate, Zobeida, Baoan Ji, Adel K. El-Naggar, and Craig D. Logsdon. "Abstract 2357: Novel transgenic animal model of salivary gland tumors." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2357.

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Ünlü, Elif Işılay, and Ahmet Çınar. "Lesion Detection on Skin Images Using Improved U-Net." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.022.

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The fate of transgenic DNA (tDNA) and protein of feeds from Genetically Modified organisms (GMOs) in animals has been an important topic since their commercialization in 1996. Several studies have investigated about risks of horizontal gene transfer (HGT) of tDNA and proteins to bacteria or animal cells/tissues, however, the reported data is at times controversial. Earlier reports showed that tDNA fragments or protein derived from GM plants have not been detected in tissues, fluids, or edible products of farm animals. Other researchers have come out to demonstrate that there is the possibility of small fragments leaking out into the animal tissues, fluids and organs. This motivated us to update our knowledge about these concerns. Therefore, this review aimed at assessing the likely transfer and accumulation of tDNA/ proteins from transgenic feeds to animal (ruminants and non-ruminants) samples through evaluating the available experimental scientific published studies. This study has found out that the tDNA or protein is not completely degraded during feed processing and digestion in the Gastro-Intestinal Tract (GIT). In large ruminants (Cattle), tDNA fragments/protein have been detected in the GIT digesta, ruminal fluid and feces. In small ruminants (Goats), traces of tDNA/proteins have been detected in the GIT digesta, blood, milk, liver, kidney, heart and muscle. In pigs, they have been detected in blood, spleen, liver kidney and in the GIT digesta. In poultry, traces have been seen in blood, liver and GIT digesta but not in meat and Eggs. Regardless of some studies that have shown the transfer of tDNA/protein fragments to animal samples, we cannot base on these few studies to give a piece of general evidence about their transfer into tissues/fluids and organs of livestock animals. However, this study clearly shows possible transfer, hence intensive and authentic research on GM crops should be done before they are allowed for commercial use, studying issues like the fate of tDNA or proteins and the effect of feeding GM feeds to livestock.
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Rizzuto, E., A. Musarò, A. Catizone, and Z. Del Prete. "Morpho-Functional Interaction Between Muscle and Tendon in Hypertrophic MLC/mIGF-1 Mice." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19332.

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Tendons and ligaments are uniaxial viscoelastic connective tissues and, during normal activity, tendons transmit forces from muscles to bones, while ligaments stabilize the joints. Many experiments have been carried out to study ligaments and tendons mechanical properties [1], and the effects of training protocols [2] or specific pathologies. Recently, different transgenic mice models have been proposed as a new way to study in depth tendons’ function and development [3]. Within this context, we made use of pathological and transgenic animal models to investigate the morpho-functional interaction between muscles with an altered functionality and their tendons. In a previous work, by using the animal model of human Duchenne dystrophy, mdx, we found out that tendons connected to muscles with functional defects present reduced mechanical properties and an altered balance between alive and dead cells [4]. Here, we evaluated whether hypertrophic muscles would also involve alterations in tendon biomechanical properties. To do this, we used the transgenic animal model MLC/mIgf-1, were the local form of Igf-1 is over-expressed under a muscle specific promoter [5] inducing an increase in skeletal muscle mass and a proportional increment of force. To determine tendons’ elastic and viscous response separately, complex compliance has been computed with a new experimental method [6] which uses a pseudorandom Gaussian noise (PGN) to stimulate all the frequencies of interest within its bandwidth. Elasticity determines the tissue response to loading while viscous dissipation affects the likelihood of injuries to tendons. Indeed, knowing tendinous tissue viscoelasticity is central to better understand the mechanism between energy dissipation and tissue injuries. Finally, the hypothesis that changes in tendons’ mechanical properties could be correlated with alterations in the balance between alive and dead cells has been tested with an in situ cellular analysis.
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Salleh, Mohd Nazil, Tan Mei Cheng, Thuaibah Hashim, Henkie Isahwan Ahamd Mulyadi Lai, and Wan Khairuzzaman Wan Ramli. "Abstract A51: p53 and p21 mRNA and protein expression in treated synthetic estrogen in mouse transgenic animal model." In Abstracts: Third AACR International Conference on Frontiers in Basic Cancer Research - September 18-22, 2013; National Harbor, MD. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.fbcr13-a51.

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DeLeo, Michael J., Matthew J. Gounis, Ajay K. Wakhloo, and Alexei A. Bogdanov. "Validation of Di-5-HT-Gd-DTPA, an Enzyme-Specific MR Contrast Agent for Myeloperoxidase, in the Rabbit Elastase Model of Cerebrovascular Aneurysm." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206346.

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Characterization of molecular imaging probes in multiple animal models of disease is essential to increase their diagnostic potential. For example, we recently demonstrated visualization of active inflammation in a rabbit model saccular aneurysm using clinical field strength MRI and the paramagnetic MR contrast agent di-5-HT-GdDTPA, which has been shown in vitro to be sensitive and specific for the enzyme myeloperoxidase (MPO). While the use of transgenic mice (MPO−/−) has demonstrated specificity of di-5-HT-GdDTPA for MPO in a model of myocardial infarction [1], MPO-deficient rabbits are not available. Therefore, in this study, we sought to validate di-5-HT-GdDTPA MPO specificity in the New Zealand white rabbit by comparing serial enhancement ratios of di-5-HT-GdDTPA to a structurally similar MR contrast agent, di-Tyr-GdDTPA, which is activated by peroxidases but not by MPO. Structural diagrams of the synthesis of the two agents are demonstrated in Figure 1 [2].
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Użarowska, E., Rafał Czajkowski, and W. Konopka. "WP1: transgenic opto-animals." In Symposium on Photonics Applications in Astronomy, Communications, Industry and High-Energy Physics Experiments, edited by Ryszard S. Romaniuk. SPIE, 2014. http://dx.doi.org/10.1117/12.2075210.

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Willett, Nick J., John Oshinski, Don Giddens, Robert Guldberg, and W. Robert Taylor. "Redox Signaling in an In Vivo Murine Model of Tailored Wall Shear Stress." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206511.

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Wall Shear Stress (WSS) has been identified as an important factor in the pathogenesis of atherosclerosis. We developed a novel murine aortic coarctation model to alter the hemodynamic environment in vivo. The model utilizes the shape memory response of nitinol clips to provide a high degree of control over aortic diameter and subsequently WSS. We employed this model to test the hypothesis that acute changes in WSS in vivo induce upregulation of inflammatory proteins mediated by Reactive Oxygen Species (ROS). WSS was mapped through a computational fluid dynamic model and correlated to inflammatory marker expression. C57B16 control mice were compared to tempol treated, apocynin treated, p47phox KO, and catalase overexpressor mice in this study. The results show that the coarctation produces low mean oscillatory WSS in the region downstream of the clip. The WSS in this region correlates to a large increase in VCAM-1 expression in wild-type mice. This WSS dependent increase in protein expression is unchanged in animal models of decreased ROS. This suggests that although the redox state is important to the overall pathogenesis of the disease, individual ROS or ROS sources may not be sufficient to inhibit a WSS dependent inflammatory response. Further analysis with this model utilizing other reagent treatments, transgenic mice, and markers will allow us to analyze the functional contribution of transcription factors, ROS, and ROS sources to WSS dependent inflammatory protein expression.
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Kacskovics, Imre. "Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptors as a result of augmented humoral immunity." In The 2nd World Congress on New Technologies. Avestia Publishing, 2016. http://dx.doi.org/10.11159/icbb16.1.

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Chiravarambath, Sidharth, Narendra K. Simha, and Jack L. Lewis. "Poroviscoelastic Properties of Mouse Cartilage From Inverse Finite Elements and Indentation." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176688.

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Transgenic mice offer a novel way to probe structure function relationships in healthy and osteoarthritic cartilage. Indentation is a convenient method to measure mechanical properties of cartilage in the mouse. In order to reduce test data to material properties, test model geometry along with a material model needs to be assumed. Most recent developments support the use of a poroviscoelastic (PVE) model for cartilage. However, using this model makes separation of the flow-dependent and flow-independent viscoelastic parameters challenging. For cartilage from larger animals, Huang [1] showed that tensile tests have negligible flow-dependent response and hence can identify the flow-independent material parameters. A compression experiment can then be used to find only the flow-dependent parameters. However, limited cartilage volumes in mouse do not allow for tension tests, so mouse cartilage is primarily tested by indentation. Mak [2] has shown that fluid flow occurs mainly for times comparable to the gel diffusion time T = a2/Hκ where a is the tip size, H is the aggregate modulus and κ is permeability. Consequently, we propose use of two different sized indenters to separate flow-independent and dependent effects in mouse cartilage. One tip is small enough to make T negligible (say <0.1 s), then relaxation data will probe only the flow-independent response, whereas a second considerably larger tip will probe both flow-dependent and fluid flow effects. The data from the small indenter can be used to fit the flow-independent parameters; the data from the large indenter, in conjunction with parameters from the first fit, can be used to fit the flow-dependent parameters.
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Reports on the topic "TRANSGENIC ANIMAL"

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Burdette, Joanna E., Sharon L. Eddie, and Suzanne M. Quartuccio. Three-Dimensional Ovarian and Oviductal Culture to Enhance Transgenic Animal Studies of Cancer and Prevention. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada598580.

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Sternlicht, Mark D. Anti-Protease Inhibition of the Progression of Precursor Lesions to Malignant Mammary Cancer in a Transgenic Animal Model. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ada383024.

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Sternlicht, Mark D. Anti-Protease Inhibition of the Progression of Precursor Lesions to Malignant Mammary Cancer in a Transgenic Animal Model. Fort Belvoir, VA: Defense Technical Information Center, September 1998. http://dx.doi.org/10.21236/adb241897.

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Rubin, E. M., and A. S. Plump. The use of transgenic animals to study lipoprotein metabolism. Office of Scientific and Technical Information (OSTI), December 1993. http://dx.doi.org/10.2172/102282.

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Prince, R. M. Sperm cells as vectors in the production of transgenic animals. Office of Scientific and Technical Information (OSTI), April 1993. http://dx.doi.org/10.2172/10175384.

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