Academic literature on the topic 'TRANSGENIC ANIMAL'

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Journal articles on the topic "TRANSGENIC ANIMAL"

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Oke, Krista B., Peter A. H. Westley, Darek T. R. Moreau, and Ian A. Fleming. "Hybridization between genetically modified Atlantic salmon and wild brown trout reveals novel ecological interactions." Proceedings of the Royal Society B: Biological Sciences 280, no. 1763 (2013): 20131047. http://dx.doi.org/10.1098/rspb.2013.1047.

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Interspecific hybridization is a route for transgenes from genetically modified (GM) animals to invade wild populations, yet the ecological effects and potential risks that may emerge from such hybridization are unknown. Through experimental crosses, we demonstrate transmission of a growth hormone transgene via hybridization between a candidate for commercial aquaculture production, GM Atlantic salmon ( Salmo salar ) and closely related wild brown trout ( Salmo trutta ). Transgenic hybrids were viable and grew more rapidly than transgenic salmon and other non-transgenic crosses in hatchery-lik
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Santamaria, P. "Transgenic animal expressing diabetogenic Tcell receptor transgenes." Biofutur 1997, no. 167 (1997): 48. http://dx.doi.org/10.1016/s0294-3506(99)80369-x.

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Moore, Colin J., and T. Ben Mepham. "Transgenesis and Animal Welfare." Alternatives to Laboratory Animals 23, no. 3 (1995): 380–97. http://dx.doi.org/10.1177/026119299502300313.

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The two main techniques used in biomedical research for the production of transgenic animals have several implications for animal welfare in terms of the Three Rs of Russell & Burch. Some are intrinsic to the transgenic objectives, while others relate to the effects of mutations, transgene expression, associated methodologies, and husbandry or production systems. All of these actual and potential implications for animal welfare demand serious consideration within a broad ethical analysis of the technology. In the light, of the Three Rs, this may require a fundamental reappraisal of the pro
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TSIKA, RICHARD W. "Transgenic Animal Models." Exercise and Sport Sciences Reviews 22, no. 1 (1994): 361–434. http://dx.doi.org/10.1249/00003677-199401000-00015.

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Towell, Jo. "Transgenic animal experiments." Nature Biotechnology 11, no. 9 (1993): 966. http://dx.doi.org/10.1038/nbt0993-966.

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Park, Frank. "Lentiviral vectors: are they the future of animal transgenesis?" Physiological Genomics 31, no. 2 (2007): 159–73. http://dx.doi.org/10.1152/physiolgenomics.00069.2007.

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Lentiviral vectors have become a promising new tool for the establishment of transgenic animals and the manipulation of the mammalian genome. While conventional microinjection-based methods for transgenesis have been successful in generating small and large transgenic animals, their relatively low transgenic efficiency has opened the door for alternative approaches, including lentiviral vectors. Lentiviral vectors are an appealing tool for transgenesis in part because of their ability to incorporate into genomic DNA with high efficiency, especially in cells that are not actively dividing. Lent
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Ju Kim, H., K. i. Naruse, W. S. Choi, K. S. Im, C. S. Park, and D. I. Jin. "332 ENHANCEMENT OF GROWTH PERFORMANCE IN DOUBLE TRANSGENIC MICE WITH GROWTH HORMONE RECEPTOR AND IGF-1 RECEPTOR GENES." Reproduction, Fertility and Development 17, no. 2 (2005): 317. http://dx.doi.org/10.1071/rdv17n2ab332.

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The effect of amplifying growth-related receptor signaling, through overexpression of receptors, on growth regulation in animals was examined. Transgenic mice lines were produced by DNA microinjection using the metallothionein promoter ligated to either the growth hormone receptor (GHR) or IGF-1 receptor (IGF-1R) genes (3 GHR founders and 3 IGF-1R founders). Transgenic mouse lines were estimated to contain approximately 4 to 20 copies of transgenes per cell by Southern blot analysis. Founder mice of each transgenic line transmitted transgenes into F1 and F2 pups with Mendelian ratio. Double tr
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de Groot, Dorien M., Anton J. M. Coenen, Albert Verhofstad, François van Herp, and Gerard J. M. Martens. "In Vivo Induction of Glial Cell Proliferation and Axonal Outgrowth and Myelination by Brain-Derived Neurotrophic Factor." Molecular Endocrinology 20, no. 11 (2006): 2987–98. http://dx.doi.org/10.1210/me.2006-0168.

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Abstract Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of neuronal cell survival and differentiation factors but is thought to be involved in neuronal cell proliferation and myelination as well. To explore the role of BDNF in vivo, we employed the intermediate pituitary melanotrope cells of the amphibian Xenopus laevis as a model system. These cells mediate background adaptation of the animal by producing high levels of the prohormone proopiomelanocortin (POMC) when the animal is black adapted. We used stable X. transgenesis in combination with the POMC gene promo
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Robl, J. M., Z. Wang, P. Kasinathan, and Y. Kuroiwa. "Transgenic animal production and animal biotechnology." Theriogenology 67, no. 1 (2007): 127–33. http://dx.doi.org/10.1016/j.theriogenology.2006.09.034.

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Wigley, P., C. Becker, J. Beltrame, et al. "Site-specific transgene insertion: an approach." Reproduction, Fertility and Development 6, no. 5 (1994): 585. http://dx.doi.org/10.1071/rd9940585.

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Methods to improve the production of transgenic animals are being developed. Conventional transgenesis, involving microinjection of DNA into fertilized eggs, has a number of limitations. These result from the inability to control both the site of transgene insertion and the number of gene copies inserted. The approach described seeks to overcome these problems and to allow single copy insertion of transgenes into a defined site in animal genomes. The method involves the use of embryonic stem cells, gene targeting and the FLP recombinase system.
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Dissertations / Theses on the topic "TRANSGENIC ANIMAL"

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Gilder, Michael Frederick James. "Molecular investigations in animal models of Huntington's disease." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.

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Saijo(Kim), Misa. "Generation of transgenic animal model of hyperthyroid Graves' disease." Kyoto University, 2004. http://hdl.handle.net/2433/147457.

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Bando, Mika. "Studies on pathophysiological significance of intraislet ghrelin using transgenic animal model." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188712.

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Abilgos, Ramos Riza. "Folate profiling in wild and transgenic rice." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12870/.

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Quantitative profiling of mono- and polyglutamyl folates in rice was achieved using the microbiological assay (MA) and a newly developed liquid chromatography tandem mass spectrometry (LC-MS/MS) method. MA was used to screen 51 rice cultivars for their total folate content and LC-MS/MS was employed to measure naturally occurring mono- and polyglutamated forms of the vitamin in wild type, FPGS Os03g02030 knockout and transgenic lines with overexpressed FPGS genes and with folate binding protein from cow’s milk (cFBP) and rat’s liver (GNMT). Natural variation among rice cultivars in terms of tot
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May, Leigh A. "The production and characterisation of transgenic disease models for retinal ocular neovascularisation." University of Western Australia. Centre for Ophthalmology and Visual Science, 2004. http://theses.library.uwa.edu.au/adt-WU2006.0047.

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[Truncated abstract] One of the barriers to understanding and preventing proliferative diabetic retinopathy in humans has been the lack of an appropriate animal model. Historically dog, rat and mouse models of diabetic retinopathy have been studied but none of these exhibit the later changes of proliferative diabetic retinopathy. Animals can be rendered diabetic by surgical pancreatectomy or the use of chemicals such as allozan or streptozotocin or by feeding of a high galactose diet. Alternatively, spontaneous rodent models of diabetes have been examined such as the BB rat, KK mouse or NOD mo
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Wilbert, Friederike Kristin [Verfasser]. "Development of a transgenic animal model for measurement of intra-cellular ATP / Friederike Kristin Wilbert." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148426116/34.

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Ravache, Thaís Terpins, Renata Simões, and Marcelo Demarchi Goissis. "Geração de animais transgênicos por inoculação de vetor viral em meio de cultura de óvulos." reponame:Repositório Institucional da UFABC, 2014.

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Orientador: Prof. Dr. Marcelo Augusto Christoffolete<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biotecnociência, 2014.<br>Desde o século XV, animais fazem parte da rotina na área da pesquisa, principalmente para estudos de doenças, e hoje em dia o modelo animal mais utilizado para estes estudos é o camundongo, tendo uma participação em mais de 90% das pesquisas em todo o mundo, sendo considerado como uma primeira via para definir funções de genes em mamíferos. Os camundongos são considerados os principais modelos nas técnicas de transgenia animal, por
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Regensburger, Martin [Verfasser], and Beate [Akademischer Betreuer] Winner. "Adult neurogenesis in transgenic animal models of DYT1 primary torsion dystonia / Martin Regensburger. Betreuer: Beate Winner." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1022872877/34.

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Tsang, Kwok-yeung, and 曾國揚. "Molecular pathogenesis of abnormal chondrocyte differentiation in a transgenic mouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B4501551X.

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Tang, Zhi. "Mass spectrometry-based metabolomics to unravel alterations in hepatic cell lines and transgenic mouse model of Alzheimer's disease." HKBU Institutional Repository, 2016. http://repository.hkbu.edu.hk/etd_oa/269.

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Chapter 5 reported the study to assess whether the urinary metabolic alterations linked to early pathophysiological changes in the TgCRND8 mouse model of AD. An unbiased metabolomics approach using high resolution Orbitrap mass spectrometry coupled with hydrophilic interaction liquid chromatography was conducted to uncover the metabolic alterations as a relevant readout of biochemical activity that implicated in the pathogenesis and progression of AD in the TgCRND8 mice. A total of 73 differential metabolites of urine sample sets was identified in 12-week and 18-week transgenic mice compared t
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Books on the topic "TRANSGENIC ANIMAL"

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Flachowsky, G., ed. Animal nutrition with transgenic plants. CABI, 2013. http://dx.doi.org/10.1079/9781780641768.0000.

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Transgenic Animal Research Workshop (1988 Iowa State University). Proceedings of the Transgenic Animal Research Workshop. Technology and Social Change Program, Iowa State University, 1989.

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Chaffee, Chet. Transgenics: Changing the face of animal genetics. SRI International, Business Intelligence Program, 1989.

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Toransujenikku dōbutsu no kaihatsu: Development of transgenic animals. Shīemushī, 2001.

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Health), Symposium on Transgenic Technology in Medicine and Agriculture (1988 National Institutes of. Transgenic animals: Proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture. Butterworth-Heinemann, 1991.

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Müller, Albrecht. Ethische Aspekte der Erzeugung und Haltung transgenic Nutztiere. F. Enke, 1995.

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Buehr, Mia. Genetically modified animals: Perspectives in development and use. Ministry of the Environment and Energy, Danish Environmental Protection Agency, 1994.

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Mutant animals: Crazy creatures altered by science. Capstone Press, a Capstone imprint, 2014.

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What's wrong with my mouse?: Behavioral phenotyping of transgenic and knockout mice. 2nd ed. Wiley-Interscience, 2007.

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Health), Symposium on Transgenic Animal Models in Biomedical Research (1991 National Institutes of. Transgenic animal models in biomedical research: Proceedings of a Symposium held at the National Institutes of Health, Bethesda, Maryland, November 4-5, 1991. Armed Forces Institute of Pathology, 1992.

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Book chapters on the topic "TRANSGENIC ANIMAL"

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Turiault, Marc, Caroline Cohen, Guy Griebel, et al. "Transgenic Animal." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3635.

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Jha, Abhimanyu Kumar. "Transgenic." In Encyclopedia of Animal Cognition and Behavior. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47829-6_2050-1.

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Singh, Birbal, Gorakh Mal, Sanjeev K. Gautam, and Manishi Mukesh. "Transgenic Fish." In Advances in Animal Biotechnology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21309-1_26.

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Laible, Götz. "Production of Transgenic Livestock: Overview of Transgenic Technologies." In Animal Biotechnology 2. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92348-2_6.

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D’Silva, Joyce. "Campaigning against transgenic technology." In Animal Biotechnology and Ethics. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5783-8_7.

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Sahara, Naruhiko, Heather Melrose, Simon D'alton, and Jada Lewis. "Transgenic Animal Models of Proteinopathies." In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444341256.ch7.

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"Transgenic Animal." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_5920.

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Knudsen, Thomas B., and Judith A. Wubah. "Transgenic Animal Models." In Handbook of Developmental Neurotoxicology. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012648860-9.50014-5.

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Houdebine, Louis-Marie. "Transgenic Animal Production." In Biotechnology for Sustainable Agriculture. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-812160-3.00005-2.

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"Transgenic animal models." In Pharmaceutical Design And Development. CRC Press, 1994. http://dx.doi.org/10.1201/b12597-12.

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Conference papers on the topic "TRANSGENIC ANIMAL"

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Matovu, Jacob, and Ahmet Alçiçek. "Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.011.

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The fate of transgenic DNA (tDNA) and protein from feed derived from Genetically Modified organisms (GMOs) in animals has been a major issue since their commercialization in 1996. Several studies have investigated the risks of horizontal gene transfer (HGT) of tDNA and protein to bacteria or animal cells/tissues, but some of the reported data are controversial. Previous reports showed that tDNA fragments or proteins derived from GM plants could not be detected in tissues, fluids, or edible products from livestock. Other researchers have shown that there is a possibility of small fragments ente
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Cruz-Monserrate, Zobeida, Baoan Ji, Adel K. El-Naggar, and Craig D. Logsdon. "Abstract 2357: Novel transgenic animal model of salivary gland tumors." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2357.

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Ünlü, Elif Işılay, and Ahmet Çınar. "Lesion Detection on Skin Images Using Improved U-Net." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.022.

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The fate of transgenic DNA (tDNA) and protein of feeds from Genetically Modified organisms (GMOs) in animals has been an important topic since their commercialization in 1996. Several studies have investigated about risks of horizontal gene transfer (HGT) of tDNA and proteins to bacteria or animal cells/tissues, however, the reported data is at times controversial. Earlier reports showed that tDNA fragments or protein derived from GM plants have not been detected in tissues, fluids, or edible products of farm animals. Other researchers have come out to demonstrate that there is the possibility
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Rizzuto, E., A. Musarò, A. Catizone, and Z. Del Prete. "Morpho-Functional Interaction Between Muscle and Tendon in Hypertrophic MLC/mIGF-1 Mice." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19332.

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Tendons and ligaments are uniaxial viscoelastic connective tissues and, during normal activity, tendons transmit forces from muscles to bones, while ligaments stabilize the joints. Many experiments have been carried out to study ligaments and tendons mechanical properties [1], and the effects of training protocols [2] or specific pathologies. Recently, different transgenic mice models have been proposed as a new way to study in depth tendons’ function and development [3]. Within this context, we made use of pathological and transgenic animal models to investigate the morpho-functional interact
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Salleh, Mohd Nazil, Tan Mei Cheng, Thuaibah Hashim, Henkie Isahwan Ahamd Mulyadi Lai, and Wan Khairuzzaman Wan Ramli. "Abstract A51: p53 and p21 mRNA and protein expression in treated synthetic estrogen in mouse transgenic animal model." In Abstracts: Third AACR International Conference on Frontiers in Basic Cancer Research - September 18-22, 2013; National Harbor, MD. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.fbcr13-a51.

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DeLeo, Michael J., Matthew J. Gounis, Ajay K. Wakhloo, and Alexei A. Bogdanov. "Validation of Di-5-HT-Gd-DTPA, an Enzyme-Specific MR Contrast Agent for Myeloperoxidase, in the Rabbit Elastase Model of Cerebrovascular Aneurysm." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206346.

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Characterization of molecular imaging probes in multiple animal models of disease is essential to increase their diagnostic potential. For example, we recently demonstrated visualization of active inflammation in a rabbit model saccular aneurysm using clinical field strength MRI and the paramagnetic MR contrast agent di-5-HT-GdDTPA, which has been shown in vitro to be sensitive and specific for the enzyme myeloperoxidase (MPO). While the use of transgenic mice (MPO−/−) has demonstrated specificity of di-5-HT-GdDTPA for MPO in a model of myocardial infarction [1], MPO-deficient rabbits are not
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Użarowska, E., Rafał Czajkowski, and W. Konopka. "WP1: transgenic opto-animals." In Symposium on Photonics Applications in Astronomy, Communications, Industry and High-Energy Physics Experiments, edited by Ryszard S. Romaniuk. SPIE, 2014. http://dx.doi.org/10.1117/12.2075210.

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Willett, Nick J., John Oshinski, Don Giddens, Robert Guldberg, and W. Robert Taylor. "Redox Signaling in an In Vivo Murine Model of Tailored Wall Shear Stress." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206511.

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Wall Shear Stress (WSS) has been identified as an important factor in the pathogenesis of atherosclerosis. We developed a novel murine aortic coarctation model to alter the hemodynamic environment in vivo. The model utilizes the shape memory response of nitinol clips to provide a high degree of control over aortic diameter and subsequently WSS. We employed this model to test the hypothesis that acute changes in WSS in vivo induce upregulation of inflammatory proteins mediated by Reactive Oxygen Species (ROS). WSS was mapped through a computational fluid dynamic model and correlated to inflamma
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Kacskovics, Imre. "Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptors as a result of augmented humoral immunity." In The 2nd World Congress on New Technologies. Avestia Publishing, 2016. http://dx.doi.org/10.11159/icbb16.1.

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Chiravarambath, Sidharth, Narendra K. Simha, and Jack L. Lewis. "Poroviscoelastic Properties of Mouse Cartilage From Inverse Finite Elements and Indentation." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176688.

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Transgenic mice offer a novel way to probe structure function relationships in healthy and osteoarthritic cartilage. Indentation is a convenient method to measure mechanical properties of cartilage in the mouse. In order to reduce test data to material properties, test model geometry along with a material model needs to be assumed. Most recent developments support the use of a poroviscoelastic (PVE) model for cartilage. However, using this model makes separation of the flow-dependent and flow-independent viscoelastic parameters challenging. For cartilage from larger animals, Huang [1] showed t
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Reports on the topic "TRANSGENIC ANIMAL"

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Burdette, Joanna E., Sharon L. Eddie, and Suzanne M. Quartuccio. Three-Dimensional Ovarian and Oviductal Culture to Enhance Transgenic Animal Studies of Cancer and Prevention. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada598580.

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Sternlicht, Mark D. Anti-Protease Inhibition of the Progression of Precursor Lesions to Malignant Mammary Cancer in a Transgenic Animal Model. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada383024.

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Sternlicht, Mark D. Anti-Protease Inhibition of the Progression of Precursor Lesions to Malignant Mammary Cancer in a Transgenic Animal Model. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/adb241897.

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Rubin, E. M., and A. S. Plump. The use of transgenic animals to study lipoprotein metabolism. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/102282.

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Prince, R. M. Sperm cells as vectors in the production of transgenic animals. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/10175384.

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