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Dissertations / Theses on the topic 'Transgenic Mice'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Simard, Marie-Chantal. "Nef pathogenesis in transgenic mice." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103182.

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In order to study the functions of SIV Nef in vivo, in a small animal model, transgenic (Tg) mice expressing the SIVmac239 nef gene, under the control of the human CD4 gene promoter (CD4C) were generated. The transgene was found to be expressed in the same cells targeted by the virus, in vivo. These CD4C/SHIV-nef SIV Tg mice develop a severe AIDS-like disease, including premature death, failure to thrive/weight loss, wasting, thymic atrophy, exhibit an especially low number of peripheral CD8+ T cells as well as low number of peripheral CD4+ T cells, diarrhea, splenomegaly, kidney (interstitial

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2

Husbands, Sandra D. "Tolerance and immunity in transgenic mice." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303680.

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3

Cosentino, Lidia. "A comparison of transgenic and endogenous loci in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/NQ56223.pdf.

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4

Malmström, Vivianne. "Arthritis susceptibility and tolerance in collagen transgenic mice." Lund : Dept. of Cell and Molecular Biology, Section for Medical Inflammation Research, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38986502.html.

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5

So, Chi-leung. "Transgenic mouse model of human chondrodysplasia /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19161347.

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6

Gratao, Ana Angélica. "Impaired fertility in transgenic mice overexpressing betacellulin." [S.l.] : [s.n.], 2007. http://edoc.ub.uni-muenchen.de/archive/00006575.

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7

Gratao, Ana Angelica. "Impaired Fertility in Transgenic Mice Overexpressing Betacellulin." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-65751.

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8

Felmer, R. "Genetic manipulation of fat in transgenic mice." Thesis, University of Edinburgh, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650832.

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The present dissertation describes the use of a novel system to achieve specific cell ablation in fat tissue. The method is based on the use of <i>E.coli</i> nitroreductase (NTR) enzyme that activates certain nitro compounds into cytotoxic DNA interstrand cross-linking agents. This system was assessed first <i>in vitro,</i> in a preadipocyte cell line (3T3L1). Clones of cells that expressed NTR were successfully killed after treatment with CB1954. It was confirmed that the mechanism of cell killing involved is apoptosis and the presence of a cell-permeable metabolite that is released to the me

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9

Cox, April. "Effects of hyperoxia in alzheimers transgenic mice." Scholar Commons, 2005. http://scholarcommons.usf.edu/etd/2836.

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An association between major surgery in the elderly and precipitation of Alzheimers disease (AD) has been reported. Hyperoxia (100%) oxygen is commonly administered after surgery to increase the oxygen content of blood. However, hyperoxia is a potent cerebral vasoconstrictor and generator of free radicals, as is [beta]amyloid (A[beta];). This study was aimed at examining behavioral, neuropathological, and neurochemical effects of hyperoxia treatments in APPsw transgenic mice (Tg+), which have elevated brain A[beta]; levels by 3-4 months of age but are not yet cognitively-impaired. At 3 months

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10

Calver, Andrew Robert. "Oligodendrocyte population dynamics : insights from transgenic mice." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322239.

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11

Derrett-Smith, E. C. "Systemic sclerosis vasculopathy : exploration in transgenic mice." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383812/.

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Vascular disease in systemic sclerosis (SSc) leads to significant morbidity and mortality. No robust animal model of vasculopathy in SSc has been described. The hypothesis underpinning work described in this thesis is that a primary defect in TGFβ signalling is sufficient to generate the fibrotic, vascular and inflammatory phenotype of this condition. This is explored using a novel transgenic mouse model of SSc (TβRIIΔk-fib). The transgenic mouse strain TβRIIΔk-fib carries a kinase-deficient type II TGFβ receptor which is expressed under the control of a fibroblast specific promoter leading to

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12

蘇志良 and Chi-leung So. "Transgenic mouse model of human chondrodysplasia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31237678.

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13

衛永剛 and Wing-kong Wai. "Abnormal chondrocyte differentiation: a transgenic model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237800.

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14

Wai, Wing-kong. "Abnormal chondrocyte differentiation : a transgenic model /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19656439.

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15

Thomas, Alysia D. "Endocrine mechanisms for reproductive failure and transgene transmission in oMt1a-oGH transgenic mice /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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16

Myelnikov, Dmitriy. "Transforming mice : technique and communication in the making of transgenic animals, 1974-1988." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252737.

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17

Lemon, Jennifer Rollo C. David. "Oxidative stress and aging processes in transgenic growth hormone mice." *McMaster only, 2005.

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18

Oghumu, Steve Onyeka. "Generation and Characterization of CXCR3 Bicistronic Reporter Mice and CXCR3 Transgenic Mice." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274927351.

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19

Rizzo, Stefania. "Arrhythmogenic cardiomyopathy: electrical instability and intercalated disc abnormalities in transgenic mice." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426181.

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Aims: Mutations in genes encoding desmosomal proteins have been implicated in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy (ARVC). However, the consequences of these mutations in early disease stages are unknown. We investigated whether mutation-induced intercalated disc remodeling impacts on electrophysiological properties before the onset of cell death and replacement fibrosis. Methods and Results: Transgenic mice with cardiac overexpression of mutant Desmoglein2 (Dsg2) Dsg2-N271S (Tg-NS/L) were studied before and after the onset of cell death and replacement fibrosi

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20

Wootz, Hanna. "Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7342.

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21

Andäng, Michael. "Expression and function of ribozymes in transgenic mice /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4143-2/.

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22

Wang, Jianming. "Life without mitochondrial DNA : studies of transgenic mice /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4491-1/.

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23

Salem, Hatem. "Behavioural analysis of transgenic mice overexpressing gamma-synuclein." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/32398/.

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The alpha-synucleinopathies is a diverse group of diseases characterised by malfunctioning of alpha-synuclein protein. Parkinson’s disease is the most common of all alpha-synucleinopathies. Intracellular inclusions, like Lewy bodies and certain other abnormal structures are the pathological hallmarks of this group of neurodegenerative diseases. The main protein component of these structures is alpha-synuclien. Alpha-synuclein is a member of the synuclein family, which consists of 3 closely related proteins, alpha-, beta- and gamma-synucleins. Alpha-synuclein is more extensively studied because

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24

Scudamore, Owen. "Modelling Parkinson's disease with α-synuclein transgenic mice". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/modelling-parkinsons-disease-with-alphasynuclein-transgenic-mice(2c799251-df3c-43f8-8b29-866d06179512).html.

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Parkinson's disease is a chronic, progressive, neurodegenerative movement disorder characterised by bradykinesia, tremor at rest, rigidity and postural instability. The pathological hallmark of the malady is a loss of dopaminergic nigrostriatal neurons, coupled with the inclusion of Lewy bodies and Lewy neurites within the axons and processes of remaining neurons. The exact cause of the disorder remains elusive; however, rare inherited forms of the disease have highlighted specific genes involved in pathogenic pathways that could be germane to sporadic cases. alpha-Synuclein is one such gene,

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25

Emson, Claire Lucy. "Analysis of interleukin-13 function using transgenic mice." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624439.

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26

Downing, Alison. "Generation of Ren-2/SV40 TsTAg transgenic mice." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/13711.

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27

Klomkleaw, Wuthichai. "ATF3 transgenic mice : structural analysis of cardiac myocytes /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486457871785014.

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28

Yamada, Go. "Generation of Transgenic Mice Overexpressing a Ghrelin Analog." Kyoto University, 2011. http://hdl.handle.net/2433/135383.

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29

Collette, Nicole Marie. "Characterization of obesity in oMt1a-oGH transgenic mice /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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30

Page, Raymond Lynn. "Evaluation of techniques for the production of transgenic animals." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40112.

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31

Page, Raymond L. "Evaluation of techniques for the production of transgenic animals." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40112.

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A polymerase chain reaction (PCR) technique was used to detect transgene presence after pronuclear microinjection of mouse zygotes cultured to various stages of development. The transgene was detected in 88% of 1-cell, 88% of 2-cell, 44% of 4-cell, 40% of morula, and 29% of blastocysts. By comparison, the integration frequency for transgenic mice made using the same DNA construct was 22%. After 5 days of in vitro culture, the injected construct was detected in 83% of arrested 1-cell, 85% of arrested 2-cell, and 85% of fragmented embryos. Only 28% of zygotes cultured after microinjection of DN

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32

Chung, Chi-kin Samuel. "The development and characterization of a gene-knockout mouse model for secretin receptor /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31491121.

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33

Yang, Xiu. "Altered neuronal lineages in the facial ganglia of Hoxa₂ mutant mice." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1207189742.

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34

陳醒覺 and Sing-kwok Chan. "Mouse preproendothelin-1 gene: transgenic mouse models to study tissue-specific and developmental expression andregulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31236571.

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35

Rojas, JoseÌ-Manuel. "Identification of novel immunogenic HLA-DR-restricted peptides from tumour-associated antigens." Thesis, Nottingham Trent University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273771.

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CD4+ T cells playa central role in antitumour immunity; not only do they provide help for the development of CTL recognising tumour antigens but they can also enhance antitumour responses via indirect cytotoxic mechanisms at the tumour site. Since CD4+ T cells recognise the antigen in the form of pep tides presented on MHC class II molecules, attention has been focused in the recent years on the identification of these peptides derived from tumour antigens. Therefore the aim of this study was to identify novel immunogenic peptides derived from tumour antigens where presentation was restricted

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36

Gilder, Michael Frederick James. "Molecular investigations in animal models of Huntington's disease." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.

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37

Siu, Kwan-yin. "The development and characterization of a knockout model for secretin." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40887674.

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38

Chan, Sing-kwok. "Mouse preproendothelin-1 gene : transgenic mouse models to study tissue-specific and developmental expression and regulation /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19737002.

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39

Lee, Yin-ting. "Molecular characterization of the insertional mouse mutant yellow submarine, Ysb /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B24709372.

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40

Canseco-Sedano, Rodolfo. "Factors affecting the efficiency of gene transfer in mice." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-03172010-020810/.

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41

Wood, Stephen Andrew. "V-myc expressing transgenic mice generated by recombinant retroviral infection." Thesis, The University of Sydney, 1990. https://hdl.handle.net/2123/26388.

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Recombinant retroviruses which express the v-myc oncogene from an internal major histocompatibility class I gene, H2Kb, promoter were used to generate transgenic mice by infection of preimplantation mouse embryos. Expression of the transgene was achieved in a range of cell types including lymphoid cells and was associated with the development of lymphomas in some of these mice. V-myc expression in heart, skeletal muscle, lung, kidney and brain, however, was not associated with the transformation of these other tissues. Prior to the production of the transgenic mice, however, a series of rec

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42

Groom, Joanna Ruth School of Medicine UNSW. "Loss of immune regulatory checkpoints in BAFF transgenic mice." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/27281.

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Multiple checkpoints control the survival and activation of auto-reactive B cells. The discovery of the TNF family cytokine BAFF has been crucial to understanding peripheral B cell tolerance mechanisms. Homeostatic levels of BAFF are tightly regulated to maintain tolerance in the periphery. Chronically increased levels of BAFF lead to the survival of autoreactive B cells. Autoimmune patients display elevated serum BAFF levels. BAFF Tg mice model this situation with systemically high levels of BAFF and the subsequent development of two separate but related autoimmune syndromes; systemic lupus e

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43

Zhu, Lei 1980. "Perturbed B cell development in young B7.2 transgenic mice." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84090.

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The best-characterized costimulation system for naive T cell activation is the interaction between CD28 and B7.1 or B7.2 ligands expressed on antigen-presenting cells such as activated B cells. Unexpectedly, transgenic mice with constitutive expression of B7.2 on B lymphocytes do not develop systemic autoimmune diseases, but rather exhibit a reduction of the B cell compartment that involves a defect in B cell maturation occurring very early in the ontogeny. In this study, we show that the early B cell loss is accompanied by splenomegaly and lymphoadenopathy that are due to a dramatic an

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44

Mao, Jian-Hua. "Stochastic modelling of tumorigenesis in p53 deficient transgenic mice." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286124.

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45

Thomas, Thomas David Colin. "Immunoregulation in the NOD mouse and NOD transgenic mice." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612992.

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46

Kim, Youngwoo. "Generation of transgenic mice for conditional overexpression of Sox9." Kyoto University, 2013. http://hdl.handle.net/2433/174810.

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47

Spratt, Christopher. "Development of behavioural tasks for phenotyping of transgenic mice." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23201.

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48

Costa, Vivian. "Effects of overexpressing ASIC2a and ASIC3 in transgenic mice." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/1132.

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Acid-sensing ion channels (ASICs) are proton-gated cation channels expressed throughout the nervous system. These channels are activated by acidic pH conditions within an attainable physiologic range. The specific function of these channels has proven to be elusive, but it is clear that they are involved in various neuronal processes, both in the central nervous system as well as in the periphery.In order to further study the functions of these channels in an animal model system, transgenic animals were generated that overexpress individual ASIC subunits: ASIC2a and ASIC3. Transgenic proteins

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49

Kashinathrao, Mamta. "Recurrent genetic alterations in thymic lymphomas of LckMyrAkt2 transgenic mice." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432499.

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50

凌錦榮 and Kam-wing Ling. "Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31238993.

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