Relevant bibliographies by topics / Transglutaminase / Dissertations / Theses
To see the other types of publications on this topic, follow the link: Transglutaminase.

Dissertations / Theses on the topic 'Transglutaminase'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Transglutaminase.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Guyot, Christopher [Verfasser]. "Transglutaminase-induzierte und Transglutaminase-unterstützte Gele aus Milchproteinen / Christopher Guyot." München : Verlag Dr. Hut, 2013. http://d-nb.info/1045988979/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

GIORDANO, DEBORAH. "Transglutaminase, nutrition and human health." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382619.

Full text
Abstract:
Conoscenze preesistenti: Le transglutaminasi (TGase) sono una classe di enzimi ampiamente diffusa tra gli organismi procarioti ed eucarioti. Gli enzimi di questa famiglia catalizzano modifiche post-traduzionali in molte proteine attraverso reazioni di trasferimento dell’acile, reazioni di deaminazione e di crosslinking (polimerizzazione) tra residui peptidici di lisina (accettore di acile) e glutammina (donatore di acile) intra- o inter-catena proteica. A causa della sua facilità di espressione e di purificazione, l’unica TGase ampiamente usata per le applicazioni industriali è la TGase microb
APA, Harvard, Vancouver, ISO, and other styles
3

Bagagli, Marcela Pavan 1981. "Produção de transglutaminase de Streptomyces sp.CBMAI-837 utlizando resíduos ou subprodutos agroindustriais e aplicação em farinha de trigo." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254358.

Full text
Abstract:
Orientador: Hélia Harumi Sato<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-24T06:55:18Z (GMT). No. of bitstreams: 1 Bagagli_MarcelaPavan_D.pdf: 5889679 bytes, checksum: 9bd456830fa35028a89bffb19885f07d (MD5) Previous issue date: 2014<br>Resumo: A transglutaminase catalisa a formação de ligações cruzadas entre grupos ?-amino de resíduos de lisina e o grupo ?-carboxiamida de resíduos de glutamina de proteínas. Esta enzima pode ser usada para unir diferentes proteínas e melhorar suas propriedades funcionais.
APA, Harvard, Vancouver, ISO, and other styles
4

Johnson, Timothy Scott. "Transglutaminase apoptosis and tumour progression." Thesis, Nottingham Trent University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283035.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Carvalho, Priscila Hoffmann 1983. "Conversão de sacarose em isomaltulose e trealulose utilizando-se células de Serratia plymuthica ATCC 15928 livres e imobilizadas em diferentes matrizes com adição de transglutaminase." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254359.

Full text
Abstract:
Orientador: Hélia Harumi Sato<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-23T16:00:04Z (GMT). No. of bitstreams: 1 Carvalho_PriscilaHoffmann_D.pdf: 4102242 bytes, checksum: 1496382da70a395d87d5c8536317d42d (MD5) Previous issue date: 2013<br>Resumo: A isomaltulose e a trealulose são dissacarídeos isômeros estruturais, que podem ser obtidos a partir da sacarose utilizando-se glicosiltransferase bacteriana. Esses dissacarídeos são considerados açúcares alternativos de grande potencial para uso nas indústria
APA, Harvard, Vancouver, ISO, and other styles
6

West, Natasha. "Nanocomposite immunosensor for anti-transglutaminase antibody." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6426_1298354109.

Full text
Abstract:
<p>Coeliac disease (CD) is a gluten intolerance condition that results in the flattening of the villi, which line the bowel. It is the most common cause of malabsorption of food nutrients. This inability to absorb sufficient levels of nutrients causes many of the common symptoms experienced by CD patients. Some of the symptoms, which lead to an increase in mortality rate, include chronic diarrhea, fatigue, iron-deficient anemia and osteoporosis. People with CD have higher than normal levels of certain antibodies in their blood. Thus, the concentration of anti-transglutaminase antibody (anti-tT
APA, Harvard, Vancouver, ISO, and other styles
7

Gaudrey, Claire Anne. "Tissue transglutaminase : a new secretory protein." Thesis, Nottingham Trent University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245102.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Knight, C. Rosamund L. "Transglutaminase activity, tumour growth and metastasis." Thesis, Nottingham Trent University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278115.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sulic, Ana-marija. "Identification of tissue transglutaminase protein network." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/4484.

Full text
Abstract:
2009/2010<br>Tissue transglutaminase (TG2) is a multifunctional enyzme involved in cell growth and differentiantion, receptor mediated endocytosis, cell adhesion and morphology, stabilization of extracellular matrix, membrane trafficking and structure/function, signal transduction, regulation of cytoskeleton and apoptosis. Multiple lines of evidence suggest an involvement of TG2 autoimmune diseases, cancer and in neurodegenerative diseases, including Alzheimer's disease, progressive supranuclear palsy, Huntington's disease and Parkinson's disease. In all of the neurodegenerative diseases exa
APA, Harvard, Vancouver, ISO, and other styles
10

Melo, Ricardo Rodrigues de 1985. "Produção e caracterização bioquímica de uma nova transglutaminase microbiana = Production and biochemical characterization of a new microbial transglutaminase." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254360.

Full text
Abstract:
Orientador: Hélia Harumi Sato<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-22T23:52:05Z (GMT). No. of bitstreams: 1 Melo_RicardoRodriguesde_M.pdf: 1621799 bytes, checksum: 14182717e9ba5de8c1d5014f330c1b6c (MD5) Previous issue date: 2013<br>Resumo: Transglutaminase é uma enzima capaz de catalisar a formação de ligações cruzadas intra- e intermoleculares entre proteínas, peptídeos e aminas primárias por meio de ligações covalentes entre resíduos de lisina e glutamina. Desta forma, transglutaminase pod
APA, Harvard, Vancouver, ISO, and other styles
11

Li, Xiaoling. "Investigation of tissue transglutaminase function in apoptosis." Thesis, Nottingham Trent University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251281.

Full text
APA, Harvard, Vancouver, ISO, and other styles
12

Smethurst, Peter Alexander. "The study of transglutaminase in pancreatic islets." Thesis, Nottingham Trent University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260290.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Telci, Dilek. "Tissue transglutaminase : a novel cell adhesion protein." Thesis, Nottingham Trent University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410526.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

L'Heureux, Darryl Zachary. "The interaction of angiocidin and tissue transglutaminase." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/10102.

Full text
Abstract:
Biology<br>Ph.D.<br>Angiogenesis is the formation of new blood vessels from the endothelium of pre-existing vasculature and is the main mechanism of vascularization during physiological processes such as embryonic development, growth, regeneration, and wound healing and pathological process of vascularizing tumors. The major source of these environmental signals is the interactions between the cell and the extracellular matrix (ECM). Cell adhesion molecules are found on the surface of all cells and play a role in cell-cell and cell-extracellular matrix interactions. Tissue transglutaminase is
APA, Harvard, Vancouver, ISO, and other styles
15

D'ELETTO, MANUELA. "Transglutaminase 2 is involved in autophagosome maturation." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1168.

Full text
Abstract:
L’autofagia è un processo cellulare altamente conservato responsabile della degradazione di proteine ed organelli cellulari. L’autofagia avviene in maniera basale in condizioni normali, ma può essere indotta in risposta ad uno stress, come ad esempio deprivazione di nutrienti, ipossia, disfunzioni mitocondriali e infezioni. La transglutaminasi tissutale (TG2) si accumula, sia in vivo che in vitro, ad alti livelli in cellule in condizioni di stress. Su questa base, abbiamo deciso di studiare se la TG2 potesse giocare un ruolo nel processo autofagico. A questo proposito abbiamo utilizzato topi
APA, Harvard, Vancouver, ISO, and other styles
16

Satwekar, Abhijeet Ajit. "Site-specific modification of proteins by transglutaminase." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427542.

Full text
Abstract:
Site-specific modification of proteins by transglutaminase Transglutaminase (TGase; EC 2.3.2.13) catalyzes the reaction between the γ-amido group of a protein-bound Gln residue (–CONH2, the acceptor) and an amino group (–NH2, the donor) of an alkyl-amine (protein-CONH2 + H2N-ligand → protein-CONH-ligand + NH3). In the case of protein substrates, TGase causes an intra- and inter-molecular crosslinking of proteins by formation of an isopeptide bond involving the side chains of Gln and Lys residues. The acyl donor can be also a small amido-ligand mimicking the Gln residue, so that TGase allows
APA, Harvard, Vancouver, ISO, and other styles
17

Erkel, Joseph G. "Nachweis und Charakterisierung von Transglutaminase im menschlichen Ejakulat." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962364355.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Gunduz, Burcu. "Recombinant Transglutaminase Production By Metabolically Engineered Pichia Pastoris." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614761/index.pdf.

Full text
Abstract:
Transglutaminases (EC 2.3.2.13) are enzymes that catalyze an acyl transfer reaction between a &gamma<br>-carboxyamide group of a peptide bound glutaminyl residue (acyl donor) and a variety of primary amines (acyl acceptors), including the amino group lysine. Transglutaminase has a potential in obtaining proteins with novel properties, improving nutritional quality of foods with the addition of essential amino acids, preparing heat stable gels, developing rheological properties and mechanical strength of foods and reducing the applications of food additives. The aim of this study is to develop
APA, Harvard, Vancouver, ISO, and other styles
19

Apperley, Kim Yang-Ping. "Reversible and Photolabile Inhibitors for Human Tissue Transglutaminase." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36593.

Full text
Abstract:
Tissue transglutaminase (TG2) is a calcium-dependent enzyme that natively catalyses the formation of isopeptidic bonds between protein- or peptide-bound glutamine and lysine residues. Physiologically, it is ubiquitously expressed in tissues, with roles in cellular differentiation, extracellular matrix stabilisation, and apoptosis, among others. However, its unregulated activity has been associated with various pathologies including fibrosis, cancer and celiac disease. Since most pathologies are associated with an increased transamidation activity, efforts have been directed towards the develo
APA, Harvard, Vancouver, ISO, and other styles
20

簫乃志 and Nai-chi Siu. "Enzymatic modification of oat globulin by microbial transglutaminase." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31225147.

Full text
APA, Harvard, Vancouver, ISO, and other styles
21

Skill, Nicholas James. "Tissue transglutaminase in human and experimental diabetic nephropathy." Thesis, Nottingham Trent University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366067.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Saint, Robert Edward. "The synthesis and evaluation of potential transglutaminase inhibitors." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263941.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Mitchell, Jennifer. "Tissue transglutaminase in cells of the vessel wall." Thesis, University of Aberdeen, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420217.

Full text
Abstract:
This study investigated the distribution of tissue transglutaminase (TG2) antigen and activity in human umbilical vein endothelial cells (HUVEC) and peripheral blood derived monocytes.  Both cell types produced and secreted TG2 with an approximate 50:50 distribution between cell associated and secreted TG2.  TG2 antigen in HUVEC was principally distributed between cell lysates and extracellular matrix (ECM) samples, yet the activity of ECM samples was lower.  The  highest specific activity for both cell types was found in conditional medium.  Monocyte cell lysates activity was consistently bel
APA, Harvard, Vancouver, ISO, and other styles
24

Pinkas, Daniel Meron. "Structural and functional studies of human transglutaminase 2 /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Siu, Nai-chi. "Enzymatic modification of oat globulin by microbial transglutaminase." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23234507.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Negus, Suzanne Schleehauf. "A Novel Microbial Transglutaminase Derived From Streptoverticillium baldaccii." Thesis, Griffith University, 2002. http://hdl.handle.net/10072/367567.

Full text
Abstract:
Transglutaminase (TGase; protein-glutamine y-glutamyltransferase, E.C. 2.3.2.13) is an enzyme that catalyses the acyl transfer reaction by introducing covalent cross-links between proteins, peptides and various primary amines. Until recently, commercial TGase has been derived from mammalian origin. Calcium-dependent TGase extracted from guinea-pig liver and blood plasma have been investigated for the purpose of their application in the food industry. However, supply, complicated separation and purification procedures as well as the requirement for calcium have made it almost impossible to appl
APA, Harvard, Vancouver, ISO, and other styles
27

Vuolo, Milena Morandi 1984. "Efeito da enzima transglutaminase na digestabilidade e antigenicidade da ß-Lactoglobulina." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256382.

Full text
Abstract:
Orientador: Flavia Maria Netto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-19T11:45:02Z (GMT). No. of bitstreams: 1 Vuolo_MilenaMorandi_M.pdf: 1172548 bytes, checksum: 0065404d0770c2d788c07526e0f82ae8 (MD5) Previous issue date: 2012<br>Resumo: O leite bovino contém proteínas que são consideradas antigênicas e capazes de induzir algum tipo de resposta imunológica, dentre elas destaca-se a ß-lactoglobulina (ß-Lg). A utilização da enzima transglutaminase (TG), que catalisa reações de ligação e-(?-glut
APA, Harvard, Vancouver, ISO, and other styles
28

Branchereau, Maxime. "Rôle de la transglutaminase 2 dans le développement de l'insuffisance cardiaque." Toulouse 3, 2016. http://www.theses.fr/2016TOU30167.

Full text
Abstract:
L'insuffisance cardiaque est une cause majeure de morbidité et de mortalité dans les pays industrialisés. Ce syndrome est le résultat de nombreuses maladies cardiaques qui induisent dans un premier temps un remodelage adaptatif du coeur : 1 'hypertrophie ventriculaire gauche(HVG). Cette HVG est associée à une réorganisation de la matrice extracellulaire (MEC)nécessaire dans la phase aigüe du remodelage mais délétère à long terme. Comme d'autres gènes, celui de la transglutaminase 2 (TG2) se retrouve surexprimé dans le cadre d'une HVG. La TG2 est une protéine multifonctiounelle très complexe qu
APA, Harvard, Vancouver, ISO, and other styles
29

Gray, Alison. "In Vitro modulation and analysis of the squamous pathway in epithelial cells." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368011.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Hand, D. "The importance of transglutaminase in tumour growth and metastasis." Thesis, Nottingham Trent University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382575.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Lemos, Clarice Pires Abrantes. ""Pesquisa do anticorpo antitransglutaminase tissular avaliando as interações da transglutaminase com a fibronectina e comparação com os resultados de dois ensaios comerciais"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-29092005-123131/.

Full text
Abstract:
Os objetivos desse estudo foram: 1) Padronizar a pesquisa do anti-tTg, comparando-o com o anticorpo antiendomísio (AAE) e 2) Avaliar as interações da tTg com a fibronectina. 49 celíacos e 124 controles com AAE negativo foram avaliados. O AAE foi pesquisado por imunofluorescência indireta e a reatividade contra a tTg e a fibronectina por ELISA in house e com kits comerciais. O antitTg foi positivo em 46,9% e 100% dos celíacos com o ELISA in house e com kits comerciais, respectivamente. A adição de fibronectina não melhorou a sensibilidade do ELISA. Em conclusão: a detecção do antitTg por ELISA
APA, Harvard, Vancouver, ISO, and other styles
32

Lima, Evandro Antônio de 1985. "Estabilização, concentração, purificação e aplicação da transglutaminase microbiana de Streptomyces sp. CBMAI 837." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254351.

Full text
Abstract:
Orientador: Hélia Harumi Sato<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-16T16:22:18Z (GMT). No. of bitstreams: 1 Lima_EvandroAntoniode_M.pdf: 2108461 bytes, checksum: 6b52a40625238916bf0ef94067896ee2 (MD5) Previous issue date: 2010<br>Resumo: A transglutaminase microbiana (MTGase; EC 2.3.2.13) é uma enzima capaz de catalisar a formação de ligações covalentes cruzadas entre proteínas, peptídeos e várias aminas primárias através da reação de acil transferência entre resíduos de glutamina e lisina.
APA, Harvard, Vancouver, ISO, and other styles
33

Hajimohammad, Amir Hossein. "Wirkung der Transglutaminase (Faktor XIII) auf die endotheliale Schrankenfunktion." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96390597X.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Zotzel, Jens. "Aktivierung von Transglutaminase von Streptomyces mobaraensis und ihre Regulation." [S.l.] : [s.n.], 2002. http://elib.tu-darmstadt.de/diss/000297.

Full text
APA, Harvard, Vancouver, ISO, and other styles
35

Lefebvre, Céline. "Transglutaminase expression and activity in MC3T3-E1 osteoblast cultures." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81353.

Full text
Abstract:
Transglutaminases are enzymes that stabilize extracellular matrices by catalyzing the formation of protease-resistant isopeptide crosslinks between and within their substrate proteins. Two transglutaminase isoforms, tissue transglutaminase (tTG) and factor XIIIa (FXIIIa), are expressed in skeletal tissues. Tissue transglutaminase has been previously localized in bone to osteoblasts, the osteoid layer and the pericellular matrix of osteocytes. Factor XIIIa has been localized to mineralizing chondrocytes, however, its expression in osteoblasts has not been reported yet. In order to unders
APA, Harvard, Vancouver, ISO, and other styles
36

Nicholas, Benjamin Leo. "A study of extracellular and intracellular tissue transglutaminase activity." Thesis, Nottingham Trent University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266916.

Full text
Abstract:
Tissue-type transglutaminase (tTG) is the most ubiquitously distributed of its enzyme family, displaying a wide range of substrates. It is a multifunctional enzyme which acts as a GTP binding protein, a stabilizer of extracellular matrix proteins, and as an effector enzyme in the apoptotic cell death pathway. Recent evidence to suggest that tTG is inactive within the healthy cell has raised questions as to the exact conditions necessary for intracellular and extracellular activity of the enzyme. To investigate the role of tTG in extracellular and intracellular processes, three model cell lines
APA, Harvard, Vancouver, ISO, and other styles
37

Lindsay, Mark Andrew. "The role of transglutaminase in the pancreatic B-cell." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292309.

Full text
APA, Harvard, Vancouver, ISO, and other styles
38

Jasim, Mahmood. "Computational investigation of small-molecule human tissue transglutaminase inhibitors." Thesis, Aston University, 2017. http://publications.aston.ac.uk/33424/.

Full text
Abstract:
Human tissue transglutaminase (TG2) catalyses transamidation and deamidation reactions through a nucleophilic cysteine residue (CYS277). TG2 activity was found to increase in celiac disease, cystic fibrosis, neurodegenerative disorders and cancer. For this, TG2 has received much focus as a target for drug discovery and many inhibitors have been designed and tested. The most important of these have an electrophilic warhead that reacts covalently with CYS277 resulting in an irreversible inhibition of TG2. The work presented in this thesis aimed at the development of computational methods that co
APA, Harvard, Vancouver, ISO, and other styles
39

Villas, Boas Mariana Battaglin 1981. "Efeito da enzima transglutaminase na antigenicidade da 'Beta'-lactoglobulina." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256392.

Full text
Abstract:
Orientador: Flavia Maria Netto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-10T02:53:32Z (GMT). No. of bitstreams: 1 VillasBoas_MarianaBattaglin_M.pdf: 1570328 bytes, checksum: 8264ab45a2d69c56c77f60117495628a (MD5) Previous issue date: 2008<br>Resumo: O leite bovino contém várias proteínas que são consideradas antigênicas e capazes de induzir resposta imune, dentre elas, a ß-lactoglubulina (ß-Lg) é uma das mais antigênicas. A enzima transglutaminase (TG) é a única enzima utilizada comercialmente qu
APA, Harvard, Vancouver, ISO, and other styles
40

Filiano, Anthony J. "The protective role of transglutaminase 2 in ischemic stroke." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/filiano.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

Fidalgo, Lopez Javier. "Design, synthesis and biological evaluation of TG2 transglutaminase inhibitors." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1190/document.

Full text
Abstract:
La transglutaminase tissulaire (TG2) est une enzyme de la famille des transglutaminases (EC 2.3.2.13) qui est exprimée de manière ubiquitaire chez les mammifères. Cette enzyme catalyse la formation d'une liaison amide intra- ou intermoléculaire entre un résidu glutamine et un résidu lysine. Ce processus biologique conduit à la modification post-traductionnelle des protéines. Un nombre croissant de publications associe la surexpression de cette enzyme et la déréglementation de son activité, avec un certain nombre de pathologiques humaines telles que les maladies neurodégénératives (maladie d’Al
APA, Harvard, Vancouver, ISO, and other styles
42

Kahlem, Pascal. "Maladies genetiques neurodegeneratives et polyglutamine : role de la transglutaminase." Paris 7, 1999. http://www.theses.fr/1999PA077120.

Full text
Abstract:
Nous avons etudie un ensemble de maladies neurodegeneratives associees a des proteines contenant une sequence polyglutaminique excessivement longue, la plus frequente etant la choree de huntington. Le gain de fonction apporte par l'expansion polyglutaminique conduit a la formation d'agregats letaux pour les neurones. Pour expliquer cette agregation, nous avons postule que la transglutaminase pourrait catalyser la formation de polymeres stabilises par des liaisons (-glutamine) lysine entre les polyglutamines et des residus lysine de proteines neuronales. Nous avons montre que des peptides synth
APA, Harvard, Vancouver, ISO, and other styles
43

Franca, Celia de Jesús 1979. "Efeito da polimerização com a enzima transglutaminase na redução do potencial alergênico do isolado protéico de soro do leite." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256379.

Full text
Abstract:
Orientador: Flavia Maria Neto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-21T08:25:23Z (GMT). No. of bitstreams: 1 Franca_CeliadeJesus_M.pdf: 1711635 bytes, checksum: 8b68d7bd0f495d93e2c2949a9229045c (MD5) Previous issue date: 2012<br>Resumo: Estudos indicam que cerca de 2,5% dos recém-nascidos sofrem reações de hipersensibilidade ao leite bovino. Os principais componentes alergênicos do soro do leite bovino são as proteínas ß-Lactoglobulina (ß-Lg) e a-Lactoalbumina (a-La). A enzima transglutaminas
APA, Harvard, Vancouver, ISO, and other styles
44

Bagagli, Marcela Pavan 1981. "Produção de transglutaminase de Streptomyces sp. P20 = caracterização da enzima bruta." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254327.

Full text
Abstract:
Orientador: Helia Harumi Sato<br>Dissertação (mestrado) - Universidade Estadual de Campinas. Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-13T21:55:21Z (GMT). No. of bitstreams: 1 Bagagli_MarcelaPavan_M.pdf: 2162265 bytes, checksum: 1def96dba6cfee03d3797c85fd357d3c (MD5) Previous issue date: 2009<br>Resumo: A transglutaminase (TGase, EC 2.3.2.13) é uma enzima que catalisa a formação de ligações cruzadas entre resíduos de glutamina e aminas livres de proteínas formando agregados protéicos. Foi estudado o aumento da escala de produção da transglutaminase de Strept
APA, Harvard, Vancouver, ISO, and other styles
45

Galmiche, Cécile. "Assemblage par chimie click de fragments d’anticorps produits en bactéries pour un criblage fonctionnel rapide in vivo." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONT3507.

Full text
Abstract:
Les anticorps monoclonaux anti-tumoraux sont produits en cellules eucaryotes. Pour des raisons de temps et de cout, peu de candidats sont sélectionnés après des tests in vitro pour être produits à large échelle et testés in vivo. Pour tester plus d’anticorps plus rapidement, nous souhaitons produire des fragments variables simple chaine (scFv) chez E. coli. et les coupler à un fragment constant Fc par chimie click pour reconstituer des mimes d’immunoglobulines naturelles. Cette production indépendante des fragments est aussi un outil modulaire permettant de combiner rapidement un grand nombre
APA, Harvard, Vancouver, ISO, and other styles
46

Abbad, Lilia. "Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC118.

Full text
Abstract:
La néphropathie à IgA (IgAN), est une maladie glomérulaire chronique primitive et principale cause d'insuffisance rénale dans le monde. Les causes et les facteurs aboutissant aux dépôts des complexes d'IgA1 sont inconnus. La forme soluble du récepteur (CD89s) complexée aux IgA joue un rôle clé dans la pathogenèse de cette maladie. Actuellement, aucun traitement spécifique n'est disponible et les options thérapeutiques sont limitées. La compréhension des mécanismes de la formation de ces complexes permettra d'envisager de nouvelles approches thérapeutiques. Dans cette perspective la première pa
APA, Harvard, Vancouver, ISO, and other styles
47

Rodrigues, Ana Sofia Medeiros. "A Doença Celíaca: etiopatogenia, diagnóstico, aspetos clínicos e tratamento." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4096.

Full text
Abstract:
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A doença celíaca, caracterizada pela atrofia das vilosidades intestinais, afeta cerca de 1% da população e manifesta-se em indivíduos geneticamente predispostos. É uma doença autoimune e o seu principal agente desencadeador é o glúten, mais propiamente a gliadina, que sofre uma digestão incompleta, originando peptídeos de gliadina. Estes sofrem uma desaminação, pela ação da enzima denominada transglutaminase tecidular, tornando-o
APA, Harvard, Vancouver, ISO, and other styles
48

Souguir, Hayfa. "Propriétés physiques d'hydrogels de gélatine réticulés par voie enzymatique." Paris 6, 2013. http://www.theses.fr/2013PA066462.

Full text
Abstract:
Les hydrogels sont constitués de réseaux élastiques de polymères hydrophiles qui emprisonnent une grande quantité d’eau. La nature des liens, physique ou chimique, qui existent entre les chaînes du réseau définit en partie leurs propriétés mécaniques. Un enjeu actuel important pour les applications envisagées en médecine régénérative est le renforcement mécanique des gels qu’on peut obtenir par mélange des deux types de liens afin de profiter des avantages de leurs réseaux respectifs. La gélatine, un biopolymère, est un bon système modèle pour répondre à cet objectif, car elle offre différente
APA, Harvard, Vancouver, ISO, and other styles
49

Al-Jallad, Hadil. "Role of transglutaminase enzymes in osteoblast differentiation and matrix deposition." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106326.

Full text
Abstract:
Bone formation is an osteoblast-mediated process that is controlled by systemic factors such as hormones, growth factors and local cues that arise from the extracellular matrix (ECM). Bone ECM is elaborated by osteoblasts and therefore they can control their own activity. The ultimate goal of bone matrix formation is to elaborate an extracellular network, consisting mainly of fibronectin and collagen type I, that is capable of mineralizing and forming a strong tissue with appropriate tensile and elastic properties. This thesis describes studies that link transglutaminases (TGs), the protein cr
APA, Harvard, Vancouver, ISO, and other styles
50

Muñoz, D. "Effects of organophosphates on neural and purified liver tissue transglutaminase." Thesis, Nottingham Trent University, 2010. http://irep.ntu.ac.uk/id/eprint/253/.

Full text
Abstract:
Transglutaminase 2 (TGase 2) is a multifunctional calcium dependent enzyme that catalyzes protein modifications. TGase 2 is essential in neuronal cell differentiation and it has been reported that certain organophosphates are able to inhibit this process, and the organophosphate phenyl saligenin compound also disrupts TGase 2 activity. It has also been shown that the organophosphates chlorpyrifos (CPF) and chlorpyrifos oxon (CPFO), which cause developmental neurotoxicity, provoke several changes in differentiating rat C6 glioma cells at different levels. The aims of this thesis were to analyse
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Transglutaminase' for other source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography