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1

YILDIRIM, SAADET. "EVALUATING TWO POTENTIAL BUS RAPID TRANSIT STATION AREAS FOR TRANSIT ORIENTED DEVELOPMENT OPPORTUNITIES." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100273924.

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Hussain, Etikaf. "Transit spatial gap identification: Exploiting big transit and traffic data." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/229971/1/Etikaf_Hussain_Thesis.pdf.

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This PhD exploits the big datasets from the road transport network to accurately model the transit supply and demand, the knowledge for which is used to identify evidence-based transit gaps. The effectiveness of the proposed novel modelling is demonstrated with the case study on the Brisbane network. The developed tool assists transit stakeholders in identifying regions where transit services can be significantly improved, leading to efficient and reliable transit services.
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Misiak, Jodie Mercer. "Regional parking fee : a potential funding source for transit?" Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33048.

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Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2005.<br>Includes bibliographical references (leaves 149-154).<br>From a regional mobility perspective, Chicagoland is in serious trouble. The current Chicago Transit Authority (CTA) funding shortfall is just the most recent evidence of major flaws in the region's transit governance and finance structures. Over the past two decades, there have been numerous reasons and opportunities to modify the regional
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Lanford, Caroline. "Potential Transportation Improvements and Land Use Impacts in the Elysian Fields Corridor." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/644.

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This study examines potential transportation improvements in the Elysian Fields Avenue Corridor, and the benefit that these improvements may produce. Data for the study area are compiled and analyzed. Conceptual plans for the implementation of different transit technology alternatives were developed and assessed in terms of user benefits, cost, potential land use impacts, potential economic impacts, and feasibility. Case studies and relevant literature are reviewed. The intent of this thesis is to provide an overview of the study area prior and subsequent to Hurricane Katrina, develop pl
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Judy, Meredith H. (Meredith Hampton). "The potential for bus rapid transit to promote transit oriented development : an analysis of BRTOD in Ottawa, Brisbane, and Pittsburgh." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40122.

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Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2007.<br>Includes bibliographical references (p. 110-114).<br>This thesis explores the conditions under which bus rapid transit (BRT) can promote transit oriented development (TOD). At a time when cities throughout the U.S. are searching for methods to reduce road congestion and limit greenhouse gas emissions, it is critical that city leaders have access to research that can best direct their decisions. Most literature recognizes that, without government intervention, TOD is unlikely at rail stations.
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Workmon, Mitchell R. "Extending the market: increasing sustainability potential through public transit in Lee’s Summit." Kansas State University, 2012. http://hdl.handle.net/2097/13686.

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Master of Landscape Architecture<br>Department of Landscape Architecture/Regional & Community Planning<br>Blake Belanger<br>Investigating historical trends of public transportation, two distinct groups of riders are targeted. First, individuals living and working in large metropolitan centers, and second, people who are dependent upon public transit; referring to people who cannot afford personal automobile transportation, possess no driver’s license, or are physically unable to drive (Garrett and Taylor, 1999). Analyzing the national demographics related to age and poverty levels, transit d
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Hasoloan, Jonathan Todo. "Defining transit oriented development (TOD) potential along the commuter line stations in Jakarta." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118253.

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Thesis: M.C.P., Massachusetts Institute of Technology, Department of Urban Studies and Planning, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 87-90).<br>Transit oriented development (TOD) has been an emerging concept in Jakarta, particularly since the construction of the new Mass Rapid Transit (MRT) and Light Rail Transit (LRT). Besides the two incoming new transits, Jakarta operates an existing Commuter Line, which has a significant ridership, even compared to the forecasted ridership of the MRT Line and the LRT Line, and an extensive network co
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Strydom, Mari. "Integrated rapid transport: is the city of Cape Town utilising its full potential? / M. Strydom." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4417.

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The spatial structure of Cape Town is characterised by segregated low density development patterns and urban sprawling. With a high population growth rate and urbanisation, these patterns are becoming more prominent. Due to the spatial nature of Cape Town, a large proportion of economic activities and employment opportunities are concentrated in patches across the city. In order to combat low-density sprawl and integrate spatially separated areas the key concept ?city densification? and the various elements thereof emerged. The segregated low density city structure, the concentrated nature of
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Russell, Adam E. "Growth on the Gold Line: Evaluating the Foothill Extension and the Potential of Transit-Oriented Development." Scholarship @ Claremont, 2012. http://scholarship.claremont.edu/pomona_theses/51.

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The Gold Line Foothill Extension represents an unprecedented light rail expansion into the San Gabriel Valley from downtown Los Angeles. In examining its potential for success, transit-oriented development (TOD) appears to be an integral factor and a major opportunity to redraw growth patterns along the corridor. TOD opportunities and challenges are investigated throughout the Foothill Extension, and three towns in particular, Claremont, Monrovia, and Irwindale, are examined on the basis of their varying levels of TOD planning. The corridor features many infill sites with potential for high
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Poole, Stephen James. "The environmental impact of light rail transit systems and the potential for impact reduction." Thesis, Manchester Metropolitan University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508014.

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Roberts, Raveenia Ellisa. "Harnessing the potential of gaseous ozone for the disinfection of fresh produce in storage and transit." Thesis, University of Newcastle upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490155.

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Freshly-harvested fruit and vegetables are prone to microbial spoilage sustained during production, transportation and storage. Traditional chemical treatments, including sanitizing agents such as chlorinated compounds, fail to adequately control many of the common microbes responsible for spoilage as wen as potentially harmful human pathogens. As a result, safe, effective alternatives to current practices are urgently required to reduce spoilage, Improve food safety and gain consumer confidence. Research and commercial applications have established that ozone, a powerful oxidant, may provide
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Coolbaugh, Dylan T. "Evaluating the potential locations for transit-oriented development (TOD)| A case study of Mecklenburg County, NC." Thesis, The University of North Carolina at Greensboro, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10154633.

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<p> The work described is aimed at developing a unique and modifiable model for analyzing transit system improvements, with specific emphasis on the concept of Transit-Oriented Development (TOD). In particular, the use of multiple variables that have been developed over the years as a result of a number of transit analyses, in a novel manner is described. The area of study was the light rail transit system (LRT) known as Lynx in Mecklenburg County, NC and over a period of development between 2001 and 2012 which included the actual construction phase from 2005 to 2007. An index model was develo
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Van, der Merwe Andri. "The pursuit of urban justice through transit-orientated development: The potential of the Lansdowne-Wetton Corridor." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22729.

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South African cities are still facing highly inefficient and inequitable urban forms, established by modernist, and apartheid city models. This has resulted in low density sprawl, fragmented and segregated structures, all contributing to unsustainable and unjust city practices. The City of Cape Town is no exception. Cape Town is a tale of two cities, where the urban and spatial landscapes reflect unequal resource distribution and opportunities. Many of its residents remain trapped in an urban landscape that continues to perpetuate its city structures. More importantly, a rapidly increasing pop
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Chum, Geoffrey Linus. "Potential shift from transit to single occupancy vehicle due to adaptation of a high occupancy vehicle lane to a high occupancy toll lane." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2469.

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15

Dreier, Dennis. "Assessing the potential of fuel saving and emissions reduction of the bus rapid transit system in Curitiba, Brazil." Thesis, KTH, Energi och klimatstudier, ECS, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176398.

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The transport sector contributes significantly to global energy use and emissions due to its traditional dependency on fossil fuels. Climate change, security of energy supply and increasing mobility demand is mobilising governments around the challenges of sustainable transport. Immediate opportunities to reduce emissions exist through the adoption of new bus technologies, e.g. advanced powertrains. This thesis analysed energy use and carbon dioxide (CO2) emissions of conventional, hybrid-electric, and plug-in hybrid-electric city buses including two-axle, articulated, and biarticulated chassi
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Smith, Margaret E. "Moving Towards a Greener Future: An Investigation of How Transit-Oriented Development Has the Potential to Redefine Cities Around Sustainability." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/534.

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How does transportation shape the cities we live in? This paper takes a close look at the practice of transit-oriented development to assess its implications for the future of urban areas. Through the design of a hypothetical light rail station in the suburb of Redmond, WA, this paper demonstrates how targeting sustainable development around transit has the potential to influence entire towns to “go green,” and proposes that, moving forward, cities be designed to maximize mobility, livability, and sustainability.
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Li, Guanying. "The potential of a bus rapid transit / buses with high level of service system in metro Atlanta: A suitability and feasibility study." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51809.

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The Atlanta Metropolitan Area has been long suffering from traffic congestion, and the ongoing population growth will exacerbate the situation. On the other hand, over half of current transit riders are people from lower-income households and there is a growing senior population more than likely to rely on transit over the next two decades. One way to mitigate congestion and support transit dependent riders at the same time is to promote transit service. Enhanced bus service systems including Bus Rapid Transit (BRT) and Buses with High Level of Service (BHLS) have been gaining popularity acros
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Біловодська, Олена Анатоліївна, Елена Анатольевна Беловодская та Olena Anatoliivna Bilovodska. "Аналіз транзитного потенціалу регіонів України". Thesis, ТРИТОРІЯ, 2017. http://essuir.sumdu.edu.ua/handle/123456789/66904.

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Визначено сутність транзитного потенціалу, проаналізовано динаміку його окремих показників у 2010-2015 рр. та виконано рейтингування регіонів України за рівнем розвитку транзитного потенціалу<br>Определена сущность транзитного потенциала, проанализирована динамика его отдельных показателей в 2010-2015 гг. и выполнено рейтингование регионов Украины по уровню развития транзитного потенциала<br>The essence of transit potential is determined, the dynamics of its individual indicators in 2010-2015 is analyzed and the rating of the regions of Ukraine according to the level of development of transit
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19

Coleman, Seitu Akira. "Assessment of the Potential of Proposed Stations of the California High-Speed Rail as Major Hubs for Physical and Economic Development." DigitalCommons@CalPoly, 2018. https://digitalcommons.calpoly.edu/theses/1826.

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This study investigated the potential for development of station catchment areas around the proposed California High-Speed Rail System. The study was prompted by a review of practices of Japanese railway company groups that engage not only in train operations, but also in business diversification and property development within the station areas of their lines. These actions allow the company groups to diversify their revenues streams, increase ridership on their lines, and operate as a whole with net profits. This is in contrast to transit agencies in the United States, which only focus on tr
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Dolan, Ryan T. "Getting people out of their cars : a case study on Cape Town's Phase 1A-bus rapid transit starter route and the potential impact of a modal shift on the carbon footprint." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/4845.

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21

Oehler, Beatrice. "TRPA1 ist funktionell in Melanomzellen exprimiert, hat jedoch keinen Einfluss auf die verminderte Proliferation der Zellen nach Stimulation mit Senföl oder Zimtaldehyd." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-116482.

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Melanome zählen zu den zehn häufigsten Tumorentitäten weltweit. Bei frühzeitiger Diagnose ist eine Exzision im Gesunden kurativ. Sobald eine Resektion im Gesunden jedoch nicht mehr möglich ist, sinken die Heilungschancen drastisch. Maligne Melanome sprechen wenig auf konventionelle Tumortherapien wie Radiatio und zytostatische Chemotherapie an. Daher werden neue Therapieoptionen in der Melanomtherapie getestet. Neueste Ansätze beziehen sich auf die Modulation von Immunzellen mittels monoklonaler Antikörper sowie die Modifikation der Signaltransduktion über die Mitogen-aktivierte Protein Kinase
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TOYAMA, JUNJI, KAICHIRO KAMIYA, TAKAFUMI ANDO, HARUO HONJO, ITSUO KODAMA, and JONG-KOOK LEE. "Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy." Thesis, American Physiological Society, 1997. http://hdl.handle.net/2237/16800.

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Walker, Rebecca L. "Functional and molecular characterization of TRP channels in smooth muscle /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3068507.

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Balinas, Cassandra Z. "Impaired surface expression of Transient Receptor Potential Melastatin 2 and 3 ion channels lowers Natural Killer Cell Cytotoxic Activity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/404161.

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Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a disabling condition characterised by unexplained chronic fatigue that is associated with immune, neurological (including autonomic), musculoskeletal, cardiovascular and gastrointestinal symptoms [1, 2]. Currently, accurate diagnosis remains challenging in the absence of a clinical or laboratory test. Although the aetiology of ME/CFS remains undefined, a significant reduction in natural killer (NK) cell cytotoxicity is consistently reported in ME/CFS patients compared with healthy controls (HC) [3-6]. NK cells are effector lympho
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Dahan, Diana. "Etude des mécanismes cellulaires de l'hypertension artérielle pulmonaire : rôle des canaux TRPV dans l'hyperréactivité et le remodelage des artères pulmonaires de rat." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21843/document.

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L’hypertension pulmonaire (HTP) est la principale pathologie de la circulation pulmonaire et a un très mauvais pronostic. Elle se caractérise par une hyperréactivité et un remodelage des petites artères pulmonaires (AP) entraînant une augmentation progressive des résistances vasculaires pulmonaires, qui, ultimement, aboutit à une insuffisance cardiaque droite et au décès du patient. Il est admit que le calcium joue un rôle très important aussi bien dans les mécanismes de remodelage que dans l’hyperréactivité des AP observés dans l’HTP. Dans le présent travail, nous avons étudié l’expression et
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Bomben, Valerie Christine. "Role of transient receptor potential canonical channels in glioma cell biology." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010p/bomben.pdf.

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Kato, Kenta. "Characterization of bioactive molecules using genetically engineered ion channels." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120897.

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Katisart, Teeraporn. "Transient receptor potential function in bladder from control and streptozotocin treated rats." Thesis, University of Hertfordshire, 2011. http://hdl.handle.net/2299/6039.

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Diabetic cystopathy is a chronic and common complication of diabetes with a classical triad of symptoms; decreased bladder sensation, increased bladder capacity and impaired detrusor muscle contractility (Hunter and Moore, 2003). In animal models of diabetes such as streptozotocin-induced diabetes in the rat, abnormalities of bladder function have been reported (Longhurst and Belis, 1986). The prototypic TRPV channel, TRPV1, is activated by capsaicin, which has been shown to cause contraction of the rat bladder (Saitoh et al., 2007), and this is reduced in STZ-diabetic rat bladder (Pinna et al
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Takahashi, Nobuaki. "TRP channels as sensors of cellular redox status." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/131892.

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Polyansky, Dmitry E. "Novel Radical Peroxyester Photoinitiators: Decomposition Mechanisms and Potential Applications." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1127243953.

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Aubdool, Aisah Aniisah. "The role of the Transient Receptor Potential Ankyrin-1 in the peripheral vasculature." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-the-transient-receptor-potential-ankyrin1-in-the-peripheral-vasculature(c632b315-f86c-47f8-be01-55e1904550e1).html.

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The phenomenon of cold-induced vasodilatation (CIVD) was discovered by Sir Thomas Lewis (1930) and has been extensively investigated as it is involved in protecting against local cold-induced injury. The mechanisms underlying this well-established protective response remain unclear. The non-selective cation channel, transient receptor potential ankyrin-1 (TRPA1) is expressed in a subset of sensory neurons and acts as a polymodal membrane channel for cold sensitivity, but this remains a controversial issue in the literature. Additionally, the role of TRPA1 as a vascular cold sensor is currently
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Bodkin, Jennifer. "Investigating the role of Transient Receptor Potential Ankyrin One (TRPA1) in cardiovascular regulation." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-role-of-transient-receptor-potential-ankyrin-one-trpa1-in-cardiovascular-regulation(86e661c9-d299-45cd-b3d3-b23fe18f9181).html.

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TRPA1 is a member of the TRP superfamily; localised to neural and non-neuronal sites. TRPA1 is activated endogenously by products of oxidative stress, where its expression on sensory neurones leads to the release of vasoactive neuropeptides. Exogenous agonists of TRPAl, mustard oil and cinnamaldehyde, have been shown to cause concentration-dependent vasorelaxation of blood vessels via a variety of mechanisms. My PhD used TRPA1 WT and KO mice to investigate the potential for TRPA1 to alter peripheral artery tone and the implications of this on systemic blood pressure. I also studied the develop
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Kim, Hong Geun. "The roles of transient receptor potential channels in thermostatic behavior, in thermal acclimation, and in tonic immobility in the red flour beetle, Tribolium castaneum (coleoptera: tenebrionidae)." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18216.

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Doctor of Philosophy<br>Department of Entomology<br>David C. Margolies and Yoonseong Park<br>Organisms are capable of sensing environmental conditions through diverse mechanisms. Transient receptor potential channels (TRPs) are a cation channel family that has been found to function in diverse sensing mechanisms. In this dissertation, I identified the function of several TRPs in thermosensing and mechanosensing in the red flour beetle, Tribolium castaneum. Candidate TRPs were chosen based on homology to TRPs found and studied in Drosophila melanogaster. To identify the function of candidate TR
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Kilburn, Korey. "A Laplace Transform/Potential-Theoretic Method for Transient Acoustic Propagation in Three-Dimensional Subsonic Flows." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1279566648.

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Garcia-Elias, Heras Anna. "Molecular determinants of TRPV4 channel regulation." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/53592.

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TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this variety of activating stimuli it may have a promiscuous gating behavior which is mostly unknown. This Thesis research aims to get in-depth in the understanding of the molecular determinants of TRPV4 regulation. I provide evidences that the inositol trisphosphate receptor and its modulatory function on TRPV4 relies on its binding to the C-terminal tail of TRPV4. I discuss the role
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Uriu, Yoshitsugu. "Biochemical and biophysical characterization of Ca2+ channel complexes in neurotransmission." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/126814.

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Mergler, Stefan, Monika Valtink, Sumioka Takayoshi, et al. "Temperature-Sensitive Transient Receptor Potential Channels in Corneal Tissue Layers and Cells." Karger, 2014. https://tud.qucosa.de/id/qucosa%3A71636.

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We here provide a brief summary of the characteristics of transient receptor potential channels (TRPs) identified in corneal tissue layers and cells. In general, TRPs are nonselective cation channels which are Ca ²⁺ permeable. Most TRPs serve as thermosensitive molecular sensors (thermo-TRPs). Based on their functional importance, the possibilities are described for drug-targeting TRP activity in a clinical setting. TRPs are expressed in various tissues of the eye including both human corneal epithelial and endothelial layers as well as stromal fibroblasts and stromal nerve fibers. TRP vanillo
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Clarke, Rebecca. "An in vitro model for the study of transient receptor potential channels on human sensory neurons." Thesis, Queen's University Belfast, 2015. https://pure.qub.ac.uk/portal/en/theses/an-in-vitro-model-for-the-study-of-transient-receptor-potential-channels-on-human-sensory-neurons(0030aff3-6cb4-43bb-9a40-3e5cbc24c4bc).html.

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Sensory neurons are responsible for detecting noxious chemical, mechanical and thermal stimuli and relaying the information to the central nervous system. They also contribute to local neurogenic inflammation via the release of neuropeptides. Sensory neurons express a variety of ion channels, including the transient receptor potential (TRP) channels. TRP channels are one of the main families of ion channels responsible for nociception and are desirable targets for analgesic and anti-inflammatory therapies. TRP channel studies on human sensory neurons has been hampered by the fact that peripher
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Ferreira, Larissa Domenegueti. "Efeito do S-nitroso-N-acetilpenicilamina sobre receptores vaniloide de potencial transitório 1 em córnea de camundongos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17150/tde-05012017-093309/.

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Introdução: Receptores TRPV1 são canais catiônicos nociceptivos não seletivos. Eles desempenham um papel na sensação de dor na córnea. No presente trabalho, descreveremos a resposta do TRPV1 na córnea de camundongos e TRPV1 -/- a estímulos químicos e o efeito do SNAP sobre este receptor. Métodos: camundongos C57BL/6 e TRPV1 -/- foram comparados. As observações incluíram o influxo de cálcio na cultura, observação direta e o comportamento de limpeza do olho após o desafio na córnea com 1µM da capsaicina (CAP) com ou sem 1mM do colírio SNAP. Resultados: As características da superfície ocular não
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Chapleau, Christopher Allen. "The developmental functions of BDNF and MECP2 on dendritic and synaptic structure." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/chapleau.pdf.

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Cori, Dario. "Descrizione e analisi quantitativa dei meccanismi di gestione del calcio intracellulare nei cardiomiociti derivati da staminali pluripotenti indotte." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14749/.

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L'obiettivo di questa tesi è quello di migliorare l'attuale formulazione del primo modello finora sviluppato di cardiomiociti derivati da hiPSC, il Paci2013, attraverso l'utilizzo: i)di un set di dati sperimentali di transienti di Ca2+ e ii) di una procedura automatica per l’ottimizzazione dei parametri del modello. Il lavoro svolto per questa tesi si articola in diverse fasi. Dapprima è stata introdotta nel modello una nuova formulazione del rilascio di Ca2+ dal reticolo sarcoplasmatico, che riproduce in maniera più realistica un importante fenomeno alla base della contrazione muscolare cardi
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Velez-Ortega, Alejandra C. "TRPA1 CHANNELS IN COCHLEAR SUPPORTING CELLS REGULATE HEARING SENSITIVITY AFTER NOISE EXPOSURE." UKnowledge, 2014. http://uknowledge.uky.edu/physiology_etds/20.

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TRPA1 channels are sensors for noxious stimuli in a subset of nociceptive neurons. TRPA1 channels are also expressed in cells of the mammalian inner ear, but their function in this tissue remains unknown given that Trpa1–/– mice exhibit normal hearing, balance and sensory mechanotransduction. Here we show that non-sensory (supporting) cells of the hearing organ in the cochlea detect tissue damage via the activation of TRPA1 channels and subsequently modulate cochlear amplification through active cellshape changes. We found that cochlear supporting cells of wild type but not Trpa1–/– mice gener
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Al, Marhoon Hussain Hassan. "Adaptive Online Transient Stability Assessment of Power Systems for Operational Purposes." ScholarWorks@UNO, 2015. http://scholarworks.uno.edu/td/2036.

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Online stability assessment is an important problem that has not been solved completely yet. The purpose of this research is to tackle online transient stability assessment. Currently, most utility companies use step-by-step integration in order to set protective equipment so that they effectively work for critical contingencies. However, there are times an unforeseen contingency may occur which may cause the system to transit and the protective equipment to misoperate and does not isolate the disturbed part of the system. This research introduces a method that automatically determines a group
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Liang, Pengfei. "The modified Synchronization Modulation technique revealed mechanisms of Na,K-ATPase." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7846.

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The Na/K pumps are essential for living system and widely expressed in all eukaryotic cell membranes. By actively transporting sodium ions out of and potassium ions into the plasma membrane, Na/K pumps creates both an electrical and a chemical gradient across the plasma membrane, which are crucial for maintaining membrane potential, cell volume, and secondary active transporting of other solutes, etc. Previously, oscillating electric field with a frequency close to the mean physiological turnover rate was used to synchronize and modulate the Na/K pump molecules. Results showed that the turnove
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Lemma, S. (Siria). "Migration and adhesion associated molecules in lymphoma biology and their potential roles as biomarkers." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526216041.

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Abstract Lymphomas are a heterogeneous group of malignancies that arise from lymphatic tissues. Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma sub-type. It is an aggressive malignancy with an increasing incidence. The prognosis of DLBCL has improved significantly, but problems also remain. The clinical significance of central nervous system (CNS) relapses has become increasingly important. As secondary CNSL (sCNSL) and primary CNS lymphoma (PCNSL) are known to have poor prognoses; the prevention of sCNSL is of crucial importance. Peripheral T-cell lymphomas (PTCL) are rare n
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Tigerholm, Jenny. "A-type potassium channels in dendritic integration role in epileptogenesis /." Licentiate thesis, Stockholm : Skolan för datavetenskap och kommunikation, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11291.

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Bonet, Ivan José Magayewski 1986. "O papel do receptor TRPA1 no desenvolvimento e manutenção da hiperalgesia induzida pela carragenina." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314055.

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Orientador: Cláudia Herrera Tambeli<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-22T19:36:40Z (GMT). No. of bitstreams: 1 Bonet_IvanJoseMagayewski_M.pdf: 8243433 bytes, checksum: a5cdaab90bdcc5bbba66a0e5e4a1293f (MD5) Previous issue date: 2013<br>Resumo: O Receptor Potencial Transiente Ankiryn 1 (TRPA1) é um canal não seletivo a cátions importante na fixação do limiar nociceptivos e pertencente à superfamília de canais TRP. É expresso em fibra C-nociceptiva e células não neuronais envolvidas na liberação de mediad
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Remeniuk, Bethany Lynne. "Capturing Affective Dimensions of Cancer-Induced Bone Pain Preclinically." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556862.

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Pain is the most feared symptom of cancer and can impact patients' lives more than the cancer itself. Despite improvements in cancer prevention and detection, pain is often the first sign of cancer, with an estimated 70-75% of advanced stage cancer patients presenting with skeletal metastases. Cancer metastasis to the bone is associated with persistent pain that increases in intensity over time. Current treatments follow the World Health Organization (WHO) analgesic ladder for cancer pain management suggesting non-steroidal anti-inflammatory drugs (NSAIDs) for mild to moderate pain and opioids
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RIGAMONTI, MARCO. "HYPOTONIC STRESS-INDUCED CALCIUM SIGNALLING IN S. CEREVISIAE INVOLVES A NEW FUNGAL SPECIFIC FAMILY OF TRP-LIKE TRANSPORTERS, HOMOLOGOUS TO HUMAN MUCOLIPIN AND POLYCYSTIC KIDNEY DISEASE RELATED (PKD2) CALCIUM CHANNELS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/71811.

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Studi presenti in letteratura hanno dimostrato che nel lievito S.cerevisiae lo stress generato dallo shock ipotonico induce un aumento transiente della [Ca2+]i. Dai nostri studi risulta che lo shock ipotonico è mediato, in cellule cresciute in terreno ricco, da due componenti cineticamente distinte, una molto rapida (circa 5 secondi), leggermente inibita da calcio e dipendente dal calcio extracellulare, e l’altra più lenta (10-20 sec.), fortemente sensibile alla presenza di calcio nell’ambiente esterno, al punto da non essere rilevabile anche a concentrazioni extracellulari di 1 µM. Mentre la
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Skidmore, Trent A. "The electroencephalographic human-computer interface." Ohio : Ohio University, 1991. http://www.ohiolink.edu/etd/view.cgi?ohiou1173327705.

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