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1

Villas, Carl Jahziel, Ruela Rose Pandeling, Shequira Paet, Dayanara R. Gaan, and Genesis B. Naparan. "Analysis of Transitional Marker Usage in Expository Essays by First-Year Criminology and Hospitality Management Students at Saint Columban College." Journal of Education and Learning Reviews 2, no. 3 (2025): 171–86. https://doi.org/10.60027/jelr.2025.1395.

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Background and Aim: Coherence and cohesion are observed when ideas run smoothly with the use of correct transitional markers. This study examined the use of transitional markers in the essays of first-year Criminology and Hospitality and Management students at Saint Columban College. This study used the quantitative type of research with a purposive sampling technique where the researchers have the freedom to choose those who will be suitable to be part of the study. Analysis of 70 essays, written in response to a standardized prompt on procrastination, reveals limited usage and variety of tra
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Rodriguez, Mark Anthony. "Transition Words in the Research Output of the Senior High School Students." Psychology and Education: A Multidisciplinary Journal V33, no. 6 (2025): 627–35. https://doi.org/10.70838/pemj.330602.

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This study explores the usage of transitional markers in the 25-research outputs of the senior high school from North Central Mindanao College in Maranding, Lala, Lanao del Norte. The study aimed to explore the inaccurately and accurately used transitional markers. The study employed qualitative research design, and conducted content analysis on the research output of the students to determine the accuracies and inaccuracies on the usage of the transitional markers. Findings revealed that students generally excel in using basic transitional markers. Conclusive terms such as "Lastly" and "There
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Rodriguez, Mark Anthony. "Transition Words in the Research Output of the Senior High School Students." Psychology and Education: A Multidisciplinary Journal 33, no. 6 (2025): 627–35. https://doi.org/10.70838/pemj.330602.

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This study explores the usage of transitional markers in the 25-research outputs of the senior high school from North Central Mindanao College in Maranding, Lala, Lanao del Norte. The study aimed to explore the inaccurately and accurately used transitional markers. The study employed qualitative research design, and conducted content analysis on the research output of the students to determine the accuracies and inaccuracies on the usage of the transitional markers. Findings revealed that students generally excel in using basic transitional markers. Conclusive terms such as "Lastly" and "There
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4

Qasim, Hafiz Muhammad, and Feroza. "A Corpus-Based Analysis of Interactive Markers in English Editorials of The News and Dawn News." Journal of English Language, Literature and Education 6, no. 3 (2024): 46–68. http://dx.doi.org/10.54692/jelle.2024.0603228.

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The use of interactive markers characterises the language of newspapers, as the newspapers aim to appeal to the audience. Such markers enhance the reading ability and make the text more reader-friendly. The study aimed to explicate two interactive markers used in Pakistani English Newspaper Editorials (PENE). It examined the use of frame and transitional markers in editorials of Pakistani English newspapers. The study followed the mixed-method technique, as it was both qualitative and quantitative. The data for the analysis consisted of editorials of THE NEWS (TN) and DAWN NEWS (DN). The corpu
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5

Mineva, Ekaterina M., Maya R. Sternberg, Regan L. Bailey, Renee J. Storandt, and Christine M. Pfeiffer. "Fewer US adults had low or transitional vitamin B12 status based on the novel combined indicator of vitamin B12 status compared with individual, conventional markers, NHANES 1999–2004." American Journal of Clinical Nutrition 114, no. 3 (2021): 1070–79. http://dx.doi.org/10.1093/ajcn/nqab122.

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ABSTRACT Background Elevated plasma methylmalonic acid (MMA) and/or total homocysteine (tHcy), as well as low serum vitamin B12 and/or holotranscobalamin (holoTC) are indicative of vitamin B12 deficiency. Combined indicators (cB12), which pool some or all 4 markers into an index, may be a more reliable diagnostic tool to overcome inconclusive diagnoses with individual markers. Objectives We aimed to describe different cB12 score combinations and estimate the prevalence of low or transitional vitamin B12 status compared with individual markers. Design Using cross-sectional data for B12, MMA, an
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Arthur, Peter G., Margaret Smith, and Peter E. Hartmann. "Milk Lactose, Citrate, and Glucose as Markers of Lactogenesis in Normal and Diabetic Women." Journal of Pediatric Gastroenterology and Nutrition 9, no. 4 (1989): 488–96. http://dx.doi.org/10.1002/j.1536-4801.1989.tb09908.x.

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A study was undertaken to define an appropriate marker of lactogenesis II (the onset of copious milk secretion) in mothers, and to determine the effect of diabetes on this marker. Changes in the concentrations of three milk components—lactose, citrate, and glucose—were measured in 38 normal mothers and 6 type I diabetic mothers up to 10 days after birth. Milk yield was measured in 12 of the normal mothers, and all mothers were asked to note the time of milk “coming in” (the feeling of overfullness of the breasts). The average concentrations of lactose, citrate, and glucose in milk were low for
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7

Baguing, Gilene R. "METADISCOURSE AND DISCOURSE STRUCTURE IN L2 NARRATIVE WRITING." Cognizance Journal of Multidisciplinary Studies 4, no. 5 (2024): 218–33. http://dx.doi.org/10.47760/cognizance.2024.v04i05.020.

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The study aimed to explore the most used Metadiscourse Markers of the Grade 11 learners. Qualitative design was used in the analysis of the narrative writings of the respondents. Content analysis of the five Narrative Writings of each respondents with 5 different topics was done to analyze and interpret the most used metadiscourse markers. Based on the content analysis, the study revealed that in the use of markers such as self- mention, transitional markers, hedges and boosters helps achieve coherence and cohesion in writing narratives and that the self- mention, transitional markers, hedges
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Gilene, R. Baguing. "METADISCOURSE AND DISCOURSE STRUCTURE IN L2 NARRATIVE WRITING." Cognizance Journal of Multidisciplinary Studies (CJMS) 4, no. 5 (2024): 218–33. https://doi.org/10.47760/cognizance.2024.v04i05.020.

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The study aimed to explore the most used Metadiscourse Markers of the Grade 11 learners. Qualitative design was used in the analysis of the narrative writings of the respondents. Content analysis of the five Narrative Writings of each respondents with 5 different topics was done to analyze and interpret the most used metadiscourse markers. Based on the content analysis, the study revealed that in the use of markers such as self- mention, transitional markers, hedges and boosters helps achieve coherence and cohesion in writing narratives and that the self- mention, transitional markers, hedges
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9

Liebler, Janice M., Crystal N. Marconett, Nicholas Juul, et al. "Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 310, no. 2 (2016): L114—L120. http://dx.doi.org/10.1152/ajplung.00337.2015.

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Distal lung epithelium is maintained by proliferation of alveolar type II (AT2) cells and, for some daughter AT2 cells, transdifferentiation into alveolar type I (AT1) cells. We investigated if subpopulations of alveolar epithelial cells (AEC) exist that represent various stages in transdifferentiation from AT2 to AT1 cell phenotypes in normal adult lung and if they can be identified using combinations of cell-specific markers. Immunofluorescence microscopy showed that, in distal rat and mouse lungs, ∼20–30% of NKX2.1+ (or thyroid transcription factor 1+) cells did not colocalize with pro-surf
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10

Yousif, Nasser Ghaly, Abdallah Ali Deb, Majid Al-Matwari, and Husham J. Mousa. "Prognostic impact of expression Notch-1 in invasive bladder transitional cell carcinoma." Journal of Clinical Oncology 30, no. 5_suppl (2012): 299. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.299.

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299 Background: Notch signal pathway plays a fundamental role in mediator of tumorigenesis, either as a tumor promoter or suppressor, depending on cellular context and expression levels; we investigated the prognosis of invasive bladder transitional cell carcinoma patients with over-expression of Notch-1. Methods: Tumor tissue samples from 78 resected patients with invasive bladder transitional cell carcinoma were obtained, and immunohistochemistry was used to evaluate the expression of the molecular markers Notch-1 and Jagged-1. To further confirm the immunohistochemical results tissue sample
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Shen, Mengxia, Ziqiang Luo, and Yan Zhou. "Regeneration-Associated Transitional State Cells in Pulmonary Fibrosis." International Journal of Molecular Sciences 23, no. 12 (2022): 6757. http://dx.doi.org/10.3390/ijms23126757.

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Pulmonary fibrosis is a chronic, progressive fibrosing interstitial disease. It is characterized by fibroblast proliferation, myofibroblast activation, and massive extracellular matrix deposition. These processes result in loss of lung parenchyma function. The transdifferentiation of alveolar epithelial type II (AEC2) to alveolar epithelial type I cells (AEC1) plays an important role in the epithelial repair after lung injury. Pulmonary fibrosis begins when this transdifferentiation process is blocked. Several recent studies have found that novel transitional state cells (intermediate states i
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Santos-Cantador, Javier, Marcos Siguero-Álvarez, and José Luis de la Pompa. "Patterning Defects in Mice with Defective Ventricular Wall Maturation and Cardiomyopathy." Journal of Cardiovascular Development and Disease 12, no. 6 (2025): 224. https://doi.org/10.3390/jcdd12060224.

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Ventricular chamber development involves the coordinated maturation of diverse cardiomyocyte cell populations. In the human fetal heart, single-cell and single-nucleus RNA sequencing technologies and spatial transcriptomics reveal marked regional gene expression differences. In contrast, the mouse ventricular wall appears more homogeneous, except for a transient hybrid cardiomyocyte population co-expressing compact (Hey2) and trabecular (Irx3, Nppa, Bmp10) markers, indicating a transitional lineage state. To further investigate this, we used in situ hybridization (ISH) to examine the expressio
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Ning, Z.-F., Y.-J. Huang, T.-X. Lin, et al. "Subpopulations of Stem-like Cells in Side Population Cells from the Human Bladder Transitional Cell Cancer Cell Line T24." Journal of International Medical Research 37, no. 3 (2009): 621–30. http://dx.doi.org/10.1177/147323000903700304.

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Cancer stem cells can be isolated from human tumours using specific cell surface markers. Bladder cancer cells, however, lack specific cell surface markers, making this approach impracticable. In this study an alternative method was used, involving isolation of side population cells to explore the stem cell characteristics of bladder cancer. Side population cells were isolated from the bladder transitional cell cancer cell line T24 and examined for potential stem cell characteristics related to proliferation, cell cycle distribution, self-renewal and differentiation. It was observed that T24 s
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14

Lopez-Beltran, A., G. A. Croghan, I. Croghan, and J. F. Gaeta. "Cell and Tumor Markers’ Immunohistochemistry in Transitional Cell Carcinoma of the Bladder." Urologia Internationalis 50, no. 2 (1993): 61–64. http://dx.doi.org/10.1159/000282453.

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15

Dhan, Priyanka, Vasantha Seshu Kumari, Chaitanya Gollu, Naveen Swaroop Murikipudi, and Raghavendra Srikanth Nistala. "Thermal Stress Markers of Ongole Cattle in Transitional Phase: THI and HSP70." Indian Journal of Veterinary Sciences and Biotechnology 21, no. 2 (2025): 69–73. https://doi.org/10.48165/ijvsbt.21.2.14.

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The effect of environment on the health and productivity of the animals is well evidenced in different species of animals. Indigenous cattle were thought to be tolerant and well adapted to environmental changes, but still the effects of varying THI during the transition period has not been explored so far in connection with the expression of stress biomarkers like heat shock proteins particularly in indigenous breeds like Ongole. The present study investigated the gene expression of heat shock proteins (HSP70) in transitional Ongole cows, a dual-purpose indigenous breed from Andhra Pradesh, In
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Mcgrath, S., B. Sundbeck, C. Jonsson, et al. "POS0322 CLINICAL DISEASE ACTIVITY INDEX REMISSION IN RHEUMATOID ARTHRITIS AT 6 MONTHS IS ASSOCIATED WITH HIGHER FREQUENCY OF TRANSITIONAL B CELLS AT DIAGNOSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 405.1–406. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2283.

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BackgroundEarly intervention and implementation of effective treatment is a significant predictor of positive long-term prognosis for rheumatoid arthritis (RA). However, despite major advances in treatment options there are currently no biomarkers to clinically guide treatment selection or to identify individuals who do not respond fully to first line therapy.B cells are known to contribute to RA pathogenesis as exemplified by the success of B cell depleting treatments. It is well known that there are changes in the circulating B cell compartment in both new onset and established RA that inclu
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17

Mufeedha, Abubaker, Govindan Aparna, Mandaka P. Rajeev, Subramaniam Gomathy, and Puthen Parambath Sathi. "A Clinicopathological Study of Angiogenesis in Meningiomas Using Immunohistochemical Markers." Neurology India 73, no. 1 (2025): 95–101. https://doi.org/10.4103/neurol-india.neurol-india-d-24-00127.

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Background: Meningioma is a neoplasm arising from arachnoid cap cells and an important group of tumors of the meninges. The extent of surgical resection is one of the most important factors predicting recurrence along with histologic grading which in turn depends on factors such as the tumor site, vascularity, and peritumoral brain edema. Objectives: We studied the relationship between Vascular endothelial growth factor (VEGF) expression, angiogenesis, and peritumoral brain edema (PTBE) in different grades and subtypes of meningioma. Methods and Materials: A cross-sectional study; comprising 4
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Lin, Guizhen, Lei Zhang, Zheng Yan, et al. "Identification of heterogeneous subsets of aortic interleukin-17A-expressing CD4+ T cells in atherosclerotic mice." International Journal of Immunopathology and Pharmacology 36 (January 2022): 039463202211179. http://dx.doi.org/10.1177/03946320221117933.

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Objectives: T helper 17 (Th17) cells are involved in the inflammatory response of atherosclerosis. However, their heterogeneity in the atherosclerotic aorta remains elusive. This study was designed to identify aortic Th17 subsets. Methods: The surface markers and transcription factors of aortic interleukin-17A (IL-17A)-expressing T cells were determined by flow cytometry in an ApoE-deficient mouse atherosclerotic model. Viable aortic IL-17A-expressing T cell subsets were isolated by flow cytometry on the basis of surface markers, followed by characterizing their transcription factors by either
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AKINSEYE, TOLULOPE. "Exploring interactive metadiscourse as a practical approach to enhancing academic writing skills of newly admitted undergraduate students in Nigeria." English for Academic Purposes (EAP): New frontiers in learning to write in English 10, no. 2 (2023): 44–61. http://dx.doi.org/10.21283/2376905x.1.10.2.2756.

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Academic writing is a crucial aspect of undergraduate education, particularly for students in English as Second Language (ESL) contexts. This study investigates the use of interactive resources as discursive strategies in enhancing the academic writing skills of ESL undergraduates in Nigeria. A sample of 100 expository essays was used. The research employs both qualitative and quantitative designs. The qualitative component analyses the types and usages of discursive strategies employed in the selected expository writing, while the quantitative component involves the occurrence of these strate
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Beyazal, Mehmet, Münevver Serdaroğlu Beyazal, Maksude Esra Kadıoğlu, and Fatma Beyazal Çeliker. "The Evaluation of Paraspinal Markers in the Numbering of the Lumbosacral Transitional Vertebrae." Turkish Journal of Osteoporosis 25, no. 2 (2019): 72–77. http://dx.doi.org/10.4274/tod.galenos.2019.71676.

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21

Schrøder, Katja, Astrid Janssens, and Elisabeth Assing Hvidt. "Adverse events as transitional markers - Using liminality to understand experiences of second victims." Social Science & Medicine 268 (January 2021): 113598. http://dx.doi.org/10.1016/j.socscimed.2020.113598.

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Zaher, Aiman, and Todd Sheridan. "Tumor Markers in the Detection of Recurrent Transitional Cell Carcinoma of the Bladder." Acta Cytologica 45, no. 4 (2001): 575–81. http://dx.doi.org/10.1159/000327867.

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Sedaghat, Shirin, Elmira Gheytanchi, Mojgan Asgari, Raheleh Roudi, Hossein Keymoosi, and Zahra Madjd. "Expression of Cancer Stem Cell Markers OCT4 and CD133 in Transitional Cell Carcinomas." Applied Immunohistochemistry & Molecular Morphology 25, no. 3 (2017): 196–202. http://dx.doi.org/10.1097/pai.0000000000000291.

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May, Allison, Claire Williams, Stephanie The, et al. "Abstract PR014: Macrophage induced epithelial to mesenchymal transition in sarcomatoid renal cell carcinoma." Cancer Research 83, no. 16_Supplement (2023): PR014. http://dx.doi.org/10.1158/1538-7445.kidney23-pr014.

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Abstract Intro: Sarcomatoid de-differentiation in renal cell carcinoma (sRCC) leads to aggressive tumors that may be uniquely responsive to adjuvant immunotherapy. sRCC is thought to arise by epithelial to mesenchymal transition (EMT) of the parental tumor, most commonly clear cell RCC (ccRCC). However, factors that drive sRCC are unknown and no biomarkers exist to predict the transition. Furthermore, the immune microenvironment in sRCC is not well understood and may provide additional therapeutic targets. Here, we use spatial biology and in vitro studies to explore EMT/immune cell crosstalk i
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Carsetti, R., G. Köhler, and M. C. Lamers. "Transitional B cells are the target of negative selection in the B cell compartment." Journal of Experimental Medicine 181, no. 6 (1995): 2129–40. http://dx.doi.org/10.1084/jem.181.6.2129.

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B lymphocytes recognize antigen through membrane-bound antigen-receptors, membrane IgM and IgD (mIgM and mIgD). Binding to foreign antigens initiates a cascade of biochemical events that lead to activation and differentiation. In contrast, binding to self-antigens leads to death or to inactivation. It is commonly believed that the B cells acquire the ability to discriminate between self and nonself in the early phases of development. We report here that immature B cells, which have just emerged from the mIgMneg, B220pos pool, are not deleted upon binding of self-antigen. In vivo, developing B
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Tzafesta, Eftychia, Benedetta Saccomanno, Francesco Zangaro, Maria Rosaria Vadrucci, Valeria Specchia, and Maurizio Pinna. "DNA Barcode Gap Analysis for Multiple Marker Genes for Phytoplankton Species Biodiversity in Mediterranean Aquatic Ecosystems." Biology 11, no. 9 (2022): 1277. http://dx.doi.org/10.3390/biology11091277.

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The implementation of DNA metabarcoding and environmental DNA (eDNA) to the biodiversity assessment and biomonitoring of aquatic ecosystems has great potential worldwide. However, DNA metabarcoding and eDNA are highly reliant on the coverage of the DNA barcode reference libraries that are currently hindered by the substantial lack of reference sequences. The main objective of this study was to analyze the current coverage of DNA barcode reference libraries for phytoplankton species of the aquatic Mediterranean ecoregion in the southeast of Italy (Apulia Region) in order to assess the applicabi
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Valverde-Villegas, Jacqueline María, Mélusine Durand, Anne-Sophie Bedin, et al. "Large Stem/Progenitor-Like Cell Subsets can Also be Identified in the CD45- and CD45+/High Populations in Early Human Milk." Journal of Human Lactation 36, no. 2 (2019): 303–9. http://dx.doi.org/10.1177/0890334419885315.

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Background Stem/progenitor cells have been identified in human milk. However, characterization and percentages of cell subsets in human milk using hematopoietic stem and progenitor cell markers according to the differential expression of CD45, i.e., as CD45dim/+ (mainly hematopoietic stem/progenitor cells) and CD45- (mainly non-hematopoietic stem/progenitor cells), have not been assessed to date. Research aim To characterize stem/progenitor-like cell phenotypes in human milk and to report the percentages of these cells at two different lactation stages compared to peripheral blood. Methods Hum
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Logani, Sanjay, Esther Oliva, Mahul B. Amin, Andrew L. Folpe, Cynthia Cohen, and Robert H. Young. "Immunoprofile of Ovarian Tumors With Putative Transitional Cell (Urothelial) Differentiation Using Novel Urothelial Markers." American Journal of Surgical Pathology 27, no. 11 (2003): 1434–41. http://dx.doi.org/10.1097/00000478-200311000-00005.

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Sacristan, Felipe, Guadalupe Aparicio, Enrique Grande, et al. "Epithelial-mesenchymal transition markers in metastatic transitional cell carcinoma (mTCC) patients under vinflunine treatment." Journal of Clinical Oncology 31, no. 15_suppl (2013): e15532-e15532. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15532.

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e15532 Background: Vinflunine (VFL) demonstrated in vitro antiproliferative effects in human tumour cell lines, and in vitro antitumor activities against subcutaneous tumour xenografts. Recently, we demonstrated that VFL causes these effects through tubulin instability, which is one of the leading intracellular molecular process that drives epithelial-mesenchymal transition (EMT). In addition, VFL may induce up-regulation in expression levels of E-cadherin/N-cadherin cocient. Methods: The study included a retrospective analysis of 18 patients with mTCC treated with carboplatin-based chemothera
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Shinada, M., K. Saeki, R. Yoshitake, et al. "Evaluation of epithelial and mesenchymal cell markers in canine urinary bladder transitional cell carcinoma." Veterinary Journal 266 (December 2020): 105571. http://dx.doi.org/10.1016/j.tvjl.2020.105571.

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31

P., Rajeev T., Nabajeet Das, S. J. Baruah, et al. "Role of serum CA 19-9 as a tumor marker in TCC bladder." International Journal of Research in Medical Sciences 7, no. 4 (2019): 1239. http://dx.doi.org/10.18203/2320-6012.ijrms20191332.

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Background: There is a dearth of reliable blood and urine markers for transitional cell carcinoma of urinary bladder. CA 19-9 is a well-known marker for gastrointestinal malignancies and is being investigated for other malignancies including carcinoma bladder. In this prospective study, we evaluated the role of serum CA 19-9 as a tumor marker and correlated its level with tumor grade and stage.Methods: One hundred and fifteen patients with transitional cell carcinoma of urinary bladder and 69 healthy volunteers, as controls were included in the study. Preoperative blood sample was analysed for
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Figueroa, Angelica, Vanessa Abella, Guadalupe Aparicio, Mar Haz-Conde, Javier Gayo, and Luis M. Antón Aparicio. "Epithelial-mesenchymal transition and metastatic bladder cancer profile under vinflunine treatment." Journal of Clinical Oncology 31, no. 15_suppl (2013): e22021-e22021. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22021.

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e22021 Background: Given the role of vinflunine (VFL) in the microtubule dynamics and the link between microtubules and cell adhesions through cadherins, we have investigated the possible influence of VFL on adherens junctions through its interaction with microtubules. We have studied the implication of VFL on the reversion of epithelial-mesenchymal transition (EMT) in bladder transitional cell carcinoma and explored a possible novel molecular mechanism. Methods: Four human bladder transitional carcinoma cell lines were used to carry out the following experimental procedure: Cytotoxicity assay
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Journal, Baghdad Science. "The Prognostic Value of some Epithelial-Mesenchymal Transition Markers and Metastasis-Related Markers in Human Transitional Cell Carcinoma of the Bladder." Baghdad Science Journal 15, no. 3 (2018): 244–52. http://dx.doi.org/10.21123/bsj.15.3.244-252.

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Recent reports provided evidence that epithelial to mesenchymal transition (EMT) and some matrix metalloproteinases (MMPs) contribute to the invasion and metastasis of cancer cells. This study investigated the expression pattern of some EMT markers (E-cadherin and Vimentin) and some MMPs (MMP-2 and MMP-9) in transitional cell carcinoma (TCC). Fifty five paraffin embedded biopsies were included in this study. Expression pattern of E-cadherin and Vimentin was evaluated by immunohistochemistry while cytoplasmic mRNA expression of both MMP-2 and MMP-9 were determined by in situ hybridization. The
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Moreno, Rachel J., Yasmin W. Azzam, Serena Eng, Destanie Rose, and Paul Ashwood. "Altered Monocyte Populations and Activation Marker Expression in Children with Autism and Co-Occurring Gastrointestinal Symptoms." Biomolecules 15, no. 2 (2025): 207. https://doi.org/10.3390/biom15020207.

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Autism spectrum disorder (ASD) is an early-onset neurodevelopmental condition that now impacts 1 in 36 children in the United States and is characterized by deficits in social communication, repetitive behaviors, and restricted interests. Children with ASD also frequently experience co-morbidities including anxiety and ADHD, and up to 80% experience gastrointestinal (GI) symptoms such as constipation, diarrhea, and/or abdominal pain. Systemic immune activation and dysregulation, including increased pro-inflammatory cytokines, are frequently observed in ASD. Evidence has shown that the innate i
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Reyes, Jonathan Vincent, Tasur Seen, Bhanu Singh, and Aaron Walfish. "A Rare Presentation of Sarcomatoid Carcinoma of Duodenum: A Case Report." Journal of Investigative Medicine High Impact Case Reports 10 (January 2022): 232470962211213. http://dx.doi.org/10.1177/23247096221121392.

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Sarcomatoid tumors are very rare biphasic tumors characterized by a mixture of malignant epithelial and mesenchymal cells that have been usually identified in the lungs with other documented cases in skin, bone, thyroid gland, salivary glands, breast, and genitourinary and gastrointestinal systems. They have an incidence estimated to be 0.5 to 0.8 per 100 000 per year. Three classic features include the presence of a genuine sarcomatous component, no transitional zone between carcinomatous and sarcomatous components, and immunohistochemistry of the sarcomatous component that is positive for me
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Ayling, C. M., B. H. Moreland, J. M. Zanelli, and D. Schulster. "Human growth hormone treatment of hypophysectomized rats increases the proportion of type-1 fibres in skeletal muscle." Journal of Endocrinology 123, no. 3 (1989): 429—NP. http://dx.doi.org/10.1677/joe.0.1230429.

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ABSTRACT The studies describe alterations after hypophysectomy in the proportion of the type-1 and type-2 fibres in rat skeletal muscles, and the effects of replacement treatment with pituitary human (h) GH. Cytochemical analysis of myosin ATPase, succinate dehydrogenase and lactate dehydrogenase activities in sections of rat hind limb muscles were used as markers of fibre type and revealed that hypophysectomy reduced the proportion of type-1 fibres by 50% in soleus and in extensor digitorum longus muscles. This reduction in the proportion of type-1 fibres was accompanied by the appearance of
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Ping, An, Su Zhendong, Dai Jingxing, et al. "Discovery of Endothelium and Mesenchymal Properties of Primo Vessels in the Mesentery." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/205951.

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Recent evidences demonstrated that endothelial-to-mesenchymal transition (EndMT) has a crucial role in cancer and is recognized as a unique source of cancer-associated fibroblasts (CAFs). Primo vascular system (PVS) is a new circulatory system which may play an important role in cancer metastasis and regeneration. In the current study, we applied previously established time-saving method to identify primo vessels and further investigated the immunocytochemical properties of primo vessels. Both primo vessels and primary primo vessel cells in the mesentery expressed endothelial markers and fibro
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Kepuladze, Shota, N. Nikolaishvili, George Chichua, and George Burkadze. "Molecular markers of the progression of conjunctival neoplastic epithelial lesions and its correlation with P16 and HPV expression." Indian Journal of Pathology and Oncology 10, no. 1 (2023): 40–43. http://dx.doi.org/10.18231/j.ijpo.2023.007.

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Epithelial lesions of the conjunctiva include both benign and transitional malignant and malignant lesions., Therefore, it is important to identify molecular markers of malignant progression of these lesions.The aim of our study was to study molecular markers determining the risk of progression of epithelial neoplastic processes of the conjunctiva. The following markers were detected by standard immunohistochemical methods: Ki67, PHH3, Bcl2, P16, HPV16/18, P53, P63 and CK7.A squamous-epithelial index was also derived by evaluating standard hematoxylin-eosin (H&E)-stained fluorescence and t
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Schroder, Angie L., Belal Chami, Yuyang Liu, et al. "Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn’s Disease." Inflammatory Bowel Diseases 28, no. 4 (2021): 586–98. http://dx.doi.org/10.1093/ibd/izab239.

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Abstract Background Intestinal neutrophil recruitment is a characteristic feature of the earliest stages of inflammatory bowel disease (IBD). Neutrophil elastase (NE) and myeloperoxidase (MPO) mediate the formation of neutrophil extracellular traps (NETs); NETs produce the bactericidal oxidant hypochlorous acid (HOCl), causing host tissue damage when unregulated. The project aim was to investigate the relationship between NET formation and clinical IBD in humans. Methods Human intestinal biopsies were collected from Crohn’s disease (CD) patients, endoscopically categorized as unaffected, trans
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Tokgoz, Nil, Murat Ucar, Aylin Billur Erdogan, Koray Kilic, and Cahide Ozcan. "Are Spinal or Paraspinal Anatomic Markers Helpful for Vertebral Numbering and Diagnosing Lumbosacral Transitional Vertebrae?" Korean Journal of Radiology 15, no. 2 (2014): 258. http://dx.doi.org/10.3348/kjr.2014.15.2.258.

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Theodorescu, Dan, and Behfar Ehdaie. "Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis." Indian Journal of Urology 24, no. 1 (2008): 61. http://dx.doi.org/10.4103/0970-1591.38606.

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Aparicio, Guadalupe, Vanessa Medina Villaamil, Miquel Taron, Rafael Rosell, and Luis M. Antón Aparicio. "Predictive markers in metastatic transitional cell carcinoma (mTCC) patients treated with carboplatin plus pemetrexed regimen." Journal of Clinical Oncology 31, no. 15_suppl (2013): e15558-e15558. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15558.

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e15558 Background: Treatment with platinum derivatives plus pemetrexed has shown a benefit in metastatic transitional cell bladder carcinoma (mTCC); however, the subset of patients most likely to benefit has not yet been identified. Predictive markers of pemetrexed response can be inferred from its mechanism of action in inhibiting nucleotide synthesis. In the present study we evaluated the predictive role of BRCA1, RAP80, TS, REV3 and AEG1 mRNA levels in a series of mTCC samples from patients treated with carboplatin plus pemetrexed (CP) and correlated with pathological response to chemothera
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Sims, Gary P., Rachel Ettinger, Yuko Shirota, Cheryl H. Yarboro, Gabor G. Illei, and Peter E. Lipsky. "Identification and characterization of circulating human transitional B cells." Blood 105, no. 11 (2005): 4390–98. http://dx.doi.org/10.1182/blood-2004-11-4284.

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Abstract Murine B-cell development begins in bone marrow and results in the generation of immature transitional B cells that transit to the spleen to complete their maturation. It remains unclear whether the same developmental pathway takes place in humans. Using markers characteristic of human bone marrow immature B cells, we have identified a population of circulating human B cells with a phenotype most similar to mouse transitional type I (T1) B cells, although these human counterparts express CD5. These cells die rapidly in culture, and B-cell activation factor member of the tumor necrosis
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Guo, Xiaola, Shuai Wang, Junmei Zhang, et al. "Proteomic profiling of serum extracellular vesicles identifies diagnostic markers for echinococcosis." PLOS Neglected Tropical Diseases 16, no. 10 (2022): e0010814. http://dx.doi.org/10.1371/journal.pntd.0010814.

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Echinococcosis is a parasitic disease caused by the metacestodes of Echinococcus spp. The disease has a long latent period and is largely underdiagnosed, partially because of the lack of effective early diagnostic approaches. Using liquid chromatography-mass spectrometry, we profiled the serum-derived extracellular vesicles (EVs) of E. multilocularis-infected mice and identified three parasite-origin proteins, thioredoxin peroxidase 1 (TPx-1), transitional endoplasmic reticulum ATPase (TER ATPase), and 14-3-3, being continuously released by the parasites into the sera during the infection via
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Alanee, Shaheen Riadh, Bradley Holland, Kristin Delfino, and Danuta Dynda. "Effect of age and gender on expression levels of markers of immune cell infiltration and immune checkpoint pathways in patients with muscle-invasive transitional cell carcinoma of the bladder: A retrospective study of 50 patients treated with radical cystectomy." Journal of Clinical Oncology 37, no. 8_suppl (2019): 65. http://dx.doi.org/10.1200/jco.2019.37.8_suppl.65.

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65 Background: Older age and female gender have been associated with worse outcomes in patients with muscle invasive bladder cancer undergoing radical cystectomy. Reduced immune response has been implicated in disease metastasis and worse survival. The objective of our study was to determine the expression patterns of various cellular proteins active in immune pathways in bladder cancer patients, and assess the correlation between age, gender, and expression of these immune markers. Methods: Tissue samples were obtained from equally distributed male/female patients with/without lymph node meta
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Bukhari, Ameera M. "IgM+IgD− B cells in Human GALT Harbor Characteristics of B1 B cells." Journal of Immunology 204, no. 1_Supplement (2020): 158.14. http://dx.doi.org/10.4049/jimmunol.204.supp.158.14.

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Abstract During embryogenesis, B cell lymphopoiesis occurs in fetal liver (FL) and bone marrow (BM). B cells derived from these organs differ in their Ig VH gene usage, their morphological and functional characteristics, and they home to different organs in the mature fetus. Although in mice, FL-B cells are known to home to the peritoneum and GALT, little is known of these cells in humans. We identified a FL-like B cell population representing 10–20% of total B cells in human GALT (appendix and tonsil), but only 1–2% in peripheral blood. These cells express IgM, but not IgD on their surface, s
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Falcão, Roberto P., and Júlio C. Voltarelli. "Adult T-ALL Related to Transitional Cortical-Medullary Thymocytes with Surface Markers of the CD4 Subset." Acta Haematologica 75, no. 1 (1986): 52–53. http://dx.doi.org/10.1159/000206082.

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Theodorescu, Dan. "Commentary on Genetic Prognostic Markers for Transitional Cell Carcinoma of the Bladder: From Microscopes to Molecules." Journal of Urology 155, no. 1 (1996): 2. http://dx.doi.org/10.1016/s0022-5347(01)66523-6.

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Witjes, J. A., R. Umbas, F. M. J. Debruyne, and J. A. Schalken. "Expression of Markers for Transitional Cell Carcinoma in Normal Bladder Mucosa of Patients with Bladder Cancer." Journal of Urology 154, no. 6 (1995): 2185–89. http://dx.doi.org/10.1016/s0022-5347(01)66725-9.

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Horstmann, Marcus, Oliver Patschan, Joerg Hennenlotter, et al. "COMBINATIONS OF SEVERAL URINARY TUMOUR MARKERS CAN REDUCE FOLLOW-UP CYSTOSCOPIES IN TRANSITIONAL CELL CEARCINOMA PATIENTS." Journal of Urology 181, no. 4S (2009): 421. http://dx.doi.org/10.1016/s0022-5347(09)61193-9.

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