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Dissertations / Theses on the topic 'Translational large animal model'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Monreal, Gretel. "Ventricular Remodeling in a Large Animal Model of Heart Failure." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1210007937.

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2

Steele, Allison M. "NEW INSIGHTS INTO POST-SEPSIS MUSCLE WEAKNESS ELUCIDATED USING A NOVEL ANIMAL MODEL." UKnowledge, 2017. https://uknowledge.uky.edu/physiology_etds/37.

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Sepsis is a severe life-threatening critical illness that damages multiple physiological systems. After hospital discharge, more than 70% of severe sepsis survivors report profound weakness which significantly impacts quality of life. Such weakness gives rise to new limitations of daily living, which ultimately leads to loss of independence in many patients. Despite wide recognition of this serious issue by clinicians and researchers alike, the mechanisms contributing to chronic skeletal muscle dysfunction after sepsis are not well understood. Lack of progress in this field is largely due to t

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3

Cove-Smith, Laura Suzanne. "Cardiotoxicity from cancer therapy : a translational approach to biomarker development." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/cardiotoxicity-from-cancer-therapy-a-translational-approach-to-biomarker-development(b9cc1130-250e-4d75-84b5-bebe8148c26d).html.

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Background: Heart damage from cancer therapy is a significant problem for survivors. Some of the most effective treatments, such as anthracyclines, cause heart toxicity that can lead to significant morbidity and mortality. Cardiotoxicity also contributes to the loss of promising cancer drugs in early development and is notoriously difficult to predict. This translational project employs parallel pre-clinical and clinical studies to explore circulating biomarkers and cardiac magnetic resonance imaging (CMR) during development of anthracycline associated cardiotoxicity with the aim of finding bi

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4

Green, Andrea Michelle. "Visual-vestibular interaction in a bilateral model of the rotational and translational vestibulo-ocular reflexes : an investigation of viewing-context-dependent reflex performance." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36810.

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Traditionally, the vestibulo-ocular reflex (VOR) has been considered a stereotyped ocular counterrotation response to head movement that stabilizes a visual image on the retinae. However, during natural head movements, the appropriate magnitudes and directions of compensatory ocular deviations depend on viewing context. Moment-to-moment adjustments in VOR performance are required as gaze is redirected towards different viewing locations.<br>This thesis presents an investigation of viewing-context-dependent VOR performance through the development of a physiologically and anatomically based bila

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Hettiaratchy, Shehan Peter. "The use of mixed haematopoietic chimerism to generate allograft tolerance in a large animal model." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433322.

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6

Hossain, Mohammad Ayaz. "Candidate biomarkers of renal warm ischaemia in a donation after circulatory death large animal model." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686431.

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Background The increased use of donation after circulatory death (DCD) kidneys in the UK has followed a UK government mandate of a 50% increase in organ donation from 2008- 2013. DCD kidneys have associated higher rates of delayed graft function (DGF) and primary non-function (PNF), which is thought to be due to warm ischaemia (WI) exposure during the retrieval process. This project aimed to utilise a porcine model of DCD WI in order to examine candidate biomarkers. Both a proteomic (2D DIGE) and a genomic (expression microarray) study were undertaken with appropriate validation. Methods Sched

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7

Reichert, Johannes Christian. "Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/48080/1/Johannes_Reichert_Thesis.pdf.

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Currently, well established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, their application, however, is associated with disadvantages. These include limited access and availability, donor site morbidity and haemorrhage, increased risk of infection, and insufficient transplant integration. As a result, recent research focuses on the development of complementar

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Kyeremanteng, Catherine. "The Biological and Behavioural Effects of Electroconvulsive Stimulus in Rodents: Investigation and Translational Implications of a Genetic Animal Model of Depression." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20694.

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Electroconvulsive therapy (ECT) is one of the oldest and most effective treatments for depression; however, its biological underpinnings are poorly understood. Brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis are two chemical messenger systems implicated in the antidepressant action and cognitive side effects of ECT. The Wistar-Kyoto (WKY) strain is a genetic model of depression that shows biological, cognitive, behavioural, and treatment-response abnormalities, making it potentially a useful model in which to investigate the underpinnings of the actio

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9

Tran, Nam D. "In utero gene transfer into fetal sheep : a large animal model for in utero gene therapy /." abstract and full text PDF (UNR users only), 1999. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9961136.

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10

de, Strobel Francesca. "IN VIVO CHARACTERIZATION OF A NEW TRANSPEDICULAR APPROACH TO THE INTERVERTEBRAL DISC IN A LARGE ANIMAL MODEL." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424387.

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Back pain (BP) is a common clinical condition that leads to high morbidity with significant psychosocial and economic effects. It is the leading cause of disability in people under 45 years of age, and it results in enormous national economic losses in developed countries. The wide majority of BP is associated with degenerative changes of the intervertebral disc (IVD).  Intervertebral disc degeneration (IVDD) is an age-related chronic process that is characterized by a progressive reduction of proteoglycans and water content in the nucleus pulposus (NP) with loss of the IVD's ability to resist

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11

Parsons, Brian Andrew. "Development and validation of an isolated large animal bladder model to study the integrative physiology of the bladder." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.690897.

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Bladder function is more intricate than first thought and knowledge of its integrat ive physiology remains incomplete. In vitro research using muscle strips and isolated cells have been central to our current understanding, but these approaches fa il to reproduce the complex network of cell-cell interactions that underpin normal bladder function. Some of these shortcomings have been addressed by using whole organ preparations, but most of this work has been done with bladders harvested from rodents and small mammals. Extrapolating findings generated using small laboratory animals to the lower

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Oliveira, Maria Teresa Carvalho. "Development of a large animal model for percutaneous vertebroplasty for in vivo evaluation of a new injectable cement." Doctoral thesis, Universidade de Évora, 2017. http://hdl.handle.net/10174/21279.

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The present work aimed to test in vivo a new biomaterial for vertebral augmentation. Vertebral compression fractures not healing with conservative management are treated through minimally invasive surgical techniques. Presently, most of the cements used in percutaneous bone interventions are based on a polymeric non-resorbable matrix. However, they can present some complications. Calcium suphate-based cements are effective bone substitutes. Disadvantages include their limited shear and compressive strength. To go beyond the state of the art, a new bioactive calcium sulphate-based cement wa

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13

Li, Zhaoyang. "Novel strontium fortified calcium salt for enhancing bone formation an in vitro and in vivo large animal model study /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557108.

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14

Brunner, Nina [Verfasser]. "Metabolomics - New biomarkers for early detection of immunosuppressive-induced nephrotoxicity and chronic rejection after KTX : a translational analysis from animal model to kidney transplant patients / Nina Brunner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1042940509/34.

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15

Kettle, S. J. A. "The use of end-to-side repair of peripheral nerves for neurotization after loss of nerve tissue in a large animal model." Thesis, University of Edinburgh, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653346.

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This study uses a large animal model to compare two variations of end-to-side neurorrhaphy techniques with conventional clinically established methods of nerve repair to assess the feasibility of end-to-side suture as a technique for possible future clinical use. All the experiments were randomized and the author performed all the surgery. The nerve repairs were assessed electrophysiologically and histologically and the muscles supplied by the repaired nerves were assessed physiologically. There were no significant differences in the outcomes of nerve repair between different conventional tech

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Leonard, David. "Tolerance induction for vascularized composite allotransplantation through induction of stable hematopoietic mixed chimerism." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/tolerance-induction-for-vascularized-composite-allotransplantation-through-induction-of-stable-hematopoietic-mixed-chimerism(69cef777-5478-4322-bba4-ca955b8b1dd5).html.

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Vascularized composite allotransplantation has developed as a specialty at the interface of reconstructive and transplant surgery, offering restoration of function and form in scenarios where options for autologous reconstruction are limited, and for which the burden of donor-site morbidity may be high. Over the past 15 years some 28 patients have received face, and 85 patients upper extremity transplants. Results have been encouraging, with good functional outcomes, and the majority of patients reporting return to independence, employment and improved quality of life. However, the immunologic

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17

Niada, S. "FROM IN VITRO STUDIES TO A LARGE ANIMAL MODEL: A MULTISTEP DISSECTION ON THE FUTURE ROLE OF ADIPOSE-DERIVED STEM CELLS FOR MUSCULOSKELETAL TISSUE ENGINEERING." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229427.

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Tissue engineering is an emerging interdisciplinary field, born with the purpose to provide an alternative solution for the regeneration of lesioned or lost tissues, combining cells, biocompatible scaffolds and bioactive factors. The cells for this approach should be non-immunoreactive and non-tumorigenic. Moreover, they should be available in large amount and possess, or be able to acquire, a specific protein expression pattern similar to that of the damaged tissue and/or act as a pool of trophic factors for resident cells. All these reasons, make mesenchymal stem cells (MSCs) good candidates

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18

Sharp, III Thomas E. "DRUG AND CELL–BASED THERAPIES TO REDUCE PATHOLOGICAL REMODELING AND CARDIAC DYSFUNCTION AFTER ACUTE MYOCARDIAL INFARCTION." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/445275.

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Physiology<br>Ph.D.<br>Remarkable advances have been made in the treatment of cardiovascular diseases (CVD), however, CVD still accounts for the most deaths in industrialized nations. Ischemic heart disease (IHD) can lead to acute coronary syndrome (ACS) (myocardial infarction [MI]). The standard of care is reperfusion therapy followed by pharmacological intervention to attenuate clinical symptoms related to the MI. While survival from MI has dramatically increased with the implementation of reperfusion therapy, these individuals will inevitably suffer progressive pathological remodeling leavi

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19

Fehlings, Christiane [Verfasser]. "Physiological and morphological characterization of transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) - a large animal model for diabetes research / Christiane Fehlings." München : Verlag Dr. Hut, 2010. http://d-nb.info/1009095366/34.

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20

Braun-Reichhart, Christina Franziska Maria Verfasser], and Eckhard [Akademischer Betreuer] [Wolf. "Genotypic and phenotypic characterization of INSC94Y transgenic pigs : a novel large animal model for permanent neonatal diabetes mellitus / Christina Franziska Maria Braun-Reichhart. Betreuer: Eckhard Wolf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1045152943/34.

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21

Fountain, Stephanie M. "Monitoring healing progression and characterising the mechanical environment in a preclinical bone defect model." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/100020/1/Stephanie_Fountain_Thesis.pdf.

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This thesis contributes new methodologies for monitoring healing and characterising the mechanical environment of large segmental bone defects. Such capability is critical for understanding how successful bone healing progresses under various mechanical environments, and provides a means for detecting deviations from the norm. Whilst the most direct benefits apply to pre-clincal animal work, this thesis provides a foundation for future clinlical application.

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22

Berner, Arne. "Quantitative and qualitative assessment of the regenerative potential of osteoblasts versus bone marrow derived mesenchymal stem cells in the reconstruction of critical sized segmental tibial bone defects in a large animal model." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/61321/1/Arne_Berner_Thesis.pdf.

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This thesis is about the use of different cells for bone tissue engineering. The cells were used in combination with a novel biomaterial in a large tibial bone defects in a sheep model. Furthermore this study developed a novel cell delivery procedure for bone tissue engineering. This novel procedure of cell delivery could overcome the current problems of cell-based tissue engineering and serve as a baseline for the translation of novel concepts into clinical application.

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23

Pohl, Friederike [Verfasser]. "Stenting of the Tuba auditiva Eustachii as a valid treatment concept in chronic otitis media, chroinic auditory tube dysfunction and ists sequelae : implementation of a large animal model / Friederike Pohl." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2016. http://d-nb.info/1125396989/34.

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24

Diehl, Rita. "Verträglichkeit und Effektivität Cyclosporin A-vermittelter Immunsuppression beim Schaf für die xenogene, intrazerebrale Transplantation." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-214365.

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Einleitung Der Einsatz von Stammzellen als Grundlage neuer therapeutischer Strategien wird bereits seit über 25 Jahren intensiv erforscht. Stammzellen sind in der Lage, in verschiedene funktionale Zelltypen auszudifferenzieren und verfügen über ein enormes Proliferationspotential (NAM et al. 2015). Ausgehend von den Fähigkeiten von Stammzellen sehen Forscher und Kliniker erstmals eine realistische Möglichkeit, kurative Therapieoptionen für Erkrankungen zu entwickeln, die bisher als schwer behandelbar oder sogar unheilbar angesehen wurden. Davon könnten insbesondere Patienten chronisch-degenera

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25

Marchionne, Francesca. "INTRATHECAL DELIVERY OF BDNF TO THE LUMBAR SPINAL CORD VIA IMPLANTED MINI-PUMP RESTORES STEPPING AND MODULATES THE ACTIVITY OF THE LUMBAR SPINAL INTERNEURONS IN A LARGE ANIMAL MODEL OF SPINAL CORD INJURY." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/480625.

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Bioengineering<br>Ph.D.<br>Delivery of neurotrophins to the injury site via cellular transplants or viral vectors administration has previously been shown to promote recovery of locomotor behavior in the absence of locomotor training in adult spinalized animals. Viral vectors still pose clinical concerns associated to recombinant genetics and the lack of understanding of how they react with the human immune system. Delivery via graft of autologous fibroblast engineered to produce brain derived neurotrophic factor (BDNF) and Neurotrophin-3 (NT-3) has been shown as a valuable method; however, th

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Zhang, Yu. "Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral messenger RNA cap methyltransferase." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388027781.

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27

Starritt, Nicola Elizabeth. "An electrophysiological and morphometric study of the effect of different methods of surgical repair in motor and mixed nerves : a comparison of the repair of the facial nerve and the median nerve in a large animal model." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/30785.

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This aims of this work were to document the natural history of nerve injuries and their repair under controlled conditions in order to ascertain the outcome of different types of nerve injury and to compare the outcome of the same injuries in motor nerves and mixed nerves. The sheep model was selected as its peripheral nerves as a similar size, and behave in a similar manner to, human peripheral nerves. A set of six standardised nerve injuries (normal control, neurapraxia, axonotmesis, neurotmesis and suture repair, neurotmesis and entubulation, and nerve graft) was created in both the facial

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28

Henninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.

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Traumatic brain injury (TBI) is a leading cause of disability worldwide. Annually, 150 to 200/1,000,000 people become disabled as a result of brain trauma. Axonal degeneration is a critical, early event following TBI of all severities but whether axon degeneration is a driver of TBI remains unclear. Molecular pathways underlying the pathology of TBI have not been defined and there is no efficacious treatment for TBI. Despite this significant societal impact, surprisingly little is known about the molecular mechanisms that actively drive axon degeneration in any context and particularly followi

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Brodin, Camille. "De la paillasse au lit du patient, surmonter les problèmes de translation dans le domaine de l'AVC ischémique Single- and two- chain tissue plasminogen activator treatment differentially influence cerebral recovery after stroke Single- and two- chain tissue plasminogen activator treatment differentially influence cerebral recovery after stroke Cerebral blood flow correlates with ischemic brain lesion only when Stroke occurs awake: a preclinical model to bypass the translational roadblocks to clinic." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC427.

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Les défauts de translation des études précliniques vers les essais cliniques dans le domaine des AVC ischémiques et l'échec des développements thérapeutiques pourraient être expliqués par trois aspects : (1) le manque de compréhension des mécanismes des deux formes de rtPA, le traitement pharmacologique de l'AVC; (2) le manque d'outils adaptés d'imagerie de perfusion chez le petit animal et (3) l'influence de l'anesthésie sur l’effet des traitements testés dans les modèles animaux.Le tPA utilisé en clinique (Actilyse®) est un mélange de deux formes de tPA: une forme chaîne simple (sc-rtPA) et

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Vanelli, A. "ISOLATION, CHARACTERIZATION AND DIFFERENTIATION POTENTIAL OF CARDIAC PROGENITOR CELLS IN ADULT PIGS." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/169553.

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Cardiac progenitor cells have been recently identified in the post-natal heart. However, the experiments carried out so far were predominantly performed on mice and humans. Considering the potential future application of these cells for human cell therapy, we propose the pig as an intermediate preclinical model, due to the morphological and functional affinity of the porcine species with the human. Pig adult cardiac progenitors were isolated from explants of adult pig hearts and cultured in complete DMEM medium. Cells were analyzed for their expansion ability and for the expression of surface

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31

von, Geymüller Teresa. "Einfluss einer autologen Knochenmarkzelltherapie auf reaktive Astrogliose und Glukosetransporter-1-Expression in grauer und weißer Substanz des Großhirns nach fokaler zerebraler Ischämie beim Schaf." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-98722.

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Ziele der hier vorliegenden Arbeit waren eine immunhistochemische Analyse von GFAP (‚glial fibrillary acidic protein’) und GLUT-1 (Glukosetransporter-1) nach fokaler zerebraler Ischämie sowie deren mögliche Beeinflussung durch eine intravenöse Transplantation autologer mononukleärer Knochenmarkzellen (mKMZ) im Schafmodell. Eine differenzierte Analyse der Zielstrukturen in grauer und weißer Substanz (GS bzw. WS) sollte Aufschluss über eventuell unterschiedliche Reaktionsmuster liefern. Das Gehirnmaterial von zehn Tieren der bereits 2006/2007 stattgefundenen Studie, welche mit PET und MRT-Unters

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Ashworth, Morgan Dean. "Identification and characterization of uterine transcriptional and translational factors contributing to endocrine disruption of the pregnant and pseudopregnant model phenotype in pigs." 2009. http://digital.library.okstate.edu/etd/Ashworth_okstate_0664D_10307.pdf.

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Byrne, Liam. "Examining the effectiveness of fluid bolus therapy in the treatment of septic shock and prevention of organ failure in a large animal model." Phd thesis, 2021. http://hdl.handle.net/1885/243968.

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Fluid resuscitation is a widely recommended and used therapy in the management of septic shock. Despite widespread use there is limited evidence demonstrating efficacy. Recently the first randomised controlled study examining the effectiveness of fluid resuscitation in septic shock was published suggesting it was in fact harmful. This PhD will examine the effectiveness of fluid resuscitation in a large animal model of endotoxemic shock with the aim of establishing if it is an effective therapy for reversing shock and preventing organ failure. The first chapter will review the history of fluid

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34

Fehlings, Christiane [Verfasser]. "Physiological and morphological characterization of trangenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) : a large animal model of diabetes research / von Christiane Fehlings." 2010. http://d-nb.info/1006686401/34.

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Šmatlíková, Petra. "Postupné molekulární změny v primárních prasečích buňkách exprimujících mutovaný huntingtín." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-397731.

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Huntington's disease (HD) is inherited fatal disorder caused by CAG triplet expansions in the huntingtin gene resulting in the expression of mutated huntingtin protein (mtHtt). The main symptoms of HD are neurodegeneration, osteoporosis, testicular degeneration, loss of muscle tissue and heart muscle malfunction, weight loss, metabolic changes, and sleeping disturbances. Since huntingtin protein (Htt) has a role in several biological processes, many molecular mechanisms, like oxidative stress, mitochondrial dysfunction, DNA-damage, and others, are affected by mtHtt. However, its exact pathogen

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Trautmann, Niklas Rainer. "Das Knochenremodeling bei Osteoporose am Tiermodell des Göttinger Minischweines." Doctoral thesis, 2019. http://hdl.handle.net/11858/00-1735-0000-002E-E5D0-7.

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Sekáč, Dávid. "Vliv mutovaného huntingtinu na oxidativní stres v primárních fibroblastech izolovaných z knock-in miniprasečího modelu pro Huntingtonovu nemoc." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436405.

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Huntington's chorea is a dominantly inherited disease caused by trinucleotide (Cytosine-Adenine -Guanine) expansion in a gene coding huntingtin protein. Carriers of these mutation show symptoms associated with motor impairment, a cognitive and psychiatric disturbance, which is called Huntington's disease (HD). The major sign of HD is striatal atrophy in the middle age of life. Since it is known that huntingtin protein participates in a lot of cellular processes, such as transcriptional regulation and metabolism, these processes change by its mutation. One of the features observed in HD pathoge

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