Log in

Relevant bibliographies by topics / Translational large animal model / Journal articles

To see the other types of publications on this topic, follow the link: Translational large animal model.

Journal articles on the topic 'Translational large animal model'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Translational large animal model.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Qi, Steven S., Laura Hocum Stone, Cory Swingen, Christin Wright, and Rosemary F. Kelly. "Diastolic Dysfunction in a Translational Large Animal Model." Journal of the American College of Surgeons 231, no. 4 (2020): S46—S47. http://dx.doi.org/10.1016/j.jamcollsurg.2020.07.071.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Eaton, Samantha L., Fraser Murdoch, Nina M. Rzechorzek, et al. "Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment." Cells 11, no. 17 (2022): 2641. http://dx.doi.org/10.3390/cells11172641.

Full text

Abstract:

Issue: The impact of neurological disorders is recognised globally, with one in six people affected in their lifetime and few treatments to slow or halt disease progression. This is due in part to the increasing ageing population, and is confounded by the high failure rate of translation from rodent-derived therapeutics to clinically effective human neurological interventions. Improved translation is demonstrated using higher order mammals with more complex/comparable neuroanatomy. These animals effectually span this translational disparity and increase confidence in factors including routes o

APA, Harvard, Vancouver, ISO, and other styles

3

Obeid, Michele, Ramzy C. Khabbaz, Kelly D. Garcia, Kyle M. Schachtschneider, and Ron C. Gaba. "Translational Animal Models for Liver Cancer." American Journal of Interventional Radiology 2 (February 24, 2018): 2. http://dx.doi.org/10.25259/ajir-11-2017.

Full text

Abstract:

Animal models have become increasingly important in the study of hepatocellular carcinoma (HCC), as they serve as a critical bridge between laboratory-based discoveries and human clinical trials. Developing an ideal animal model for translational use is challenging, as the perfect model must be able to reproduce human disease genetically, anatomically, physiologically, and pathologically. This brief review provides an overview of the animal models currently available for translational liver cancer research, including rodent, rabbit, non-human primate, and pig models, with a focus on their resp

APA, Harvard, Vancouver, ISO, and other styles

4

Vilahur, Gemma, Teresa Padro, and Lina Badimon. "Atherosclerosis and Thrombosis: Insights from Large Animal Models." Journal of Biomedicine and Biotechnology 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/907575.

Full text

Abstract:

Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination ofin vitro, ex vivo, andin vivoexperimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstr

APA, Harvard, Vancouver, ISO, and other styles

5

Kőrösi, Dénes, András Vorobcsuk, Dániel Fajtai, Ottó Tátrai, Emőke Bodor, and Rita Garamvölgyi. "Closed-chest occlusion of the left anterior descending artery in swine infarction model." Acta Agraria Kaposváriensis 27, no. 1-2 (2023): 77–85. http://dx.doi.org/10.31914/aak.3423.

Full text

Abstract:

Pigs have played a significant role in biological and medical research for many years. In the case of non-rodent models, pigs are the primary choices as experimental animals in the cardiovascular studies. Accumulating data indicate that the closed-chest coronary balloon-occlusion technique is one of the most successful method for creating ischemic heart failure (HF). However, consistent and thoroughly characterized large animal models of HF are a critical translational tool for drug development and toxicology. The knowledge of the different catheterization protocols is crucial to ensure a suit

APA, Harvard, Vancouver, ISO, and other styles

6

Hollister, S. J., M. B. Wheeler, S. E. Feinberg, and W. L. Murphy. "THE IMPORTANCE OF LARGE ANIMAL MODELS FOR TRANSLATIONAL RESEARCH IN BONE TISSUE ENGINEERING." Reproduction, Fertility and Development 24, no. 1 (2012): 287. http://dx.doi.org/10.1071/rdv24n1ab249.

Full text

Abstract:

The translation of bone tissue engineering (BTE) research to clinical use has been absymal1. Outside of bone void filler biomaterials, only Bone Morphogenetic Protein 2 (BMP2) has made significant inroads to clinical practice, and even BMP2 use has been associated with significant complications including death, dysphagia, and ectopic bone formation. The dearth of BTE products can be attributed to two main causes: (1) the need to develop BTE systems, that successfully integrate scaffolds, growth factors like BMP2 and cells and (2) the need to adapt and implement such systems for a wide variety

APA, Harvard, Vancouver, ISO, and other styles

7

Taha, Aladdin, Joaquim Bobi, Ruben Dammers, et al. "Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?" Stroke 53, no. 4 (2022): 1411–22. http://dx.doi.org/10.1161/strokeaha.121.036050.

Full text

Abstract:

Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been recommended. Currently, these models include, among others, dogs, swine, sheep, and nonhuman primates that closely emulate aspects of the human setting of brain ischemia and r

APA, Harvard, Vancouver, ISO, and other styles

8

Sorby-Adams, Annabel J., Robert Vink, and Renée J. Turner. "Large animal models of stroke and traumatic brain injury as translational tools." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 2 (2018): R165—R190. http://dx.doi.org/10.1152/ajpregu.00163.2017.

Full text

Abstract:

Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide. Studies in animal models have greatly enhanced our understanding of the complex pathophysiology that underlies TBI and stroke and enabled the preclinical screening of over 1,000 novel therapeutic agents. Despite this, the translation of novel therapeutics from experimental models to clinical therapies has been extremely poor. One potential explanation for this poor clinical translation is the choice of experimental model, given that

APA, Harvard, Vancouver, ISO, and other styles

9

Walker, Rebecca L., and Matthias Eggel. "From Mice to Monkeys? Beyond Orthodox Approaches to the Ethics of Animal Model Choice." Animals 10, no. 1 (2020): 77. http://dx.doi.org/10.3390/ani10010077.

Full text

Abstract:

Recent developments in genome editing tools, along with limits in the translational potential of rodent models of human disease, have spurred renewed biomedical research interest in large mammals like nonhuman primates, pigs, and dogs. Such scientific developments raise ethical issues about the use of these animals in comparison with smaller mammals, such as mice and rats. To examine these ethical questions, we first consider standard (or “orthodox”) approaches, including ethics oversight within biomedical research communities, and critical theoretical reflections on animal research, including

APA, Harvard, Vancouver, ISO, and other styles

10

Krause, S., S. Reichert, T. Donandt, et al. "Molecular therapy in a novel translational large animal model for Duchenne muscular dystrophy." Neuromuscular Disorders 27 (October 2017): S188—S189. http://dx.doi.org/10.1016/j.nmd.2017.06.345.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Packialakshmi, Balamurugan, Ian J. Stewart, David M. Burmeister, Kevin K. Chung, and Xiaoming Zhou. "Large animal models for translational research in acute kidney injury." Renal Failure 42, no. 1 (2020): 1042–58. http://dx.doi.org/10.1080/0886022x.2020.1830108.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Kirk, Allan D. "Crossing the bridge: large animal models in translational transplantation research." Immunological Reviews 196, no. 1 (2003): 176–96. http://dx.doi.org/10.1046/j.1600-065x.2003.00081.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Bolli, Roberto, and Shahab Ghafghazi. "Cell Therapy Needs Rigorous Translational Studies in Large Animal Models ∗." Journal of the American College of Cardiology 66, no. 18 (2015): 2000–2004. http://dx.doi.org/10.1016/j.jacc.2015.09.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Gregory, Martin H., Nicholas Capito, Keiichi Kuroki, Aaron M. Stoker, James L. Cook, and Seth L. Sherman. "A Review of Translational Animal Models for Knee Osteoarthritis." Arthritis 2012 (December 27, 2012): 1–14. http://dx.doi.org/10.1155/2012/764621.

Full text

Abstract:

Knee osteoarthritis remains a tremendous public health concern, both in terms of health-related quality of life and financial burden of disease. Translational research is a critical step towards understanding and mitigating the long-term effects of this disease process. Animal models provide practical and clinically relevant ways to study both the natural history and response to treatment of knee osteoarthritis. Many factors including size, cost, and method of inducing osteoarthritis are important considerations for choosing an appropriate animal model. Smaller animals are useful because of th

APA, Harvard, Vancouver, ISO, and other styles

15

Winkler, Paige A., Laurence M. Occelli, and Simon M. Petersen-Jones. "Large Animal Models of Inherited Retinal Degenerations: A Review." Cells 9, no. 4 (2020): 882. http://dx.doi.org/10.3390/cells9040882.

Full text

Abstract:

Studies utilizing large animal models of inherited retinal degeneration (IRD) have proven important in not only the development of translational therapeutic approaches, but also in improving our understanding of disease mechanisms. The dog is the predominant species utilized because spontaneous IRD is common in the canine pet population. Cats are also a source of spontaneous IRDs. Other large animal models with spontaneous IRDs include sheep, horses and non-human primates (NHP). The pig has also proven valuable due to the ease in which transgenic animals can be generated and work is ongoing to

APA, Harvard, Vancouver, ISO, and other styles

16

Deng, Zhengyan, Peng Xi, Dongye Zheng, Zhaoheng Xie, Xiangxi Meng, and Qiushi Ren. "The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models." Biomolecules 15, no. 7 (2025): 919. https://doi.org/10.3390/biom15070919.

Full text

Abstract:

Large-animal models are playing a pivotal role in bridging the translational research gap. Positron emission tomography (PET) imaging is preferred in disease research involving large-animal models. Its ability to non-invasively monitor metabolic activity, receptor–ligand interactions, and pharmacokinetics in real time makes PET imaging an essential tool for evaluating therapeutic efficacy and advancing the development of targeted treatments. This review focuses on recent advancements in dedicated large-animal PET scanners, the utilization of large-animal models for simulating human diseases, a

APA, Harvard, Vancouver, ISO, and other styles

17

Banstola, Ashik, and John N. J. Reynolds. "The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders." Biology 11, no. 9 (2022): 1251. http://dx.doi.org/10.3390/biology11091251.

Full text

Abstract:

An essential aim of biomedical research is to translate basic science information obtained from preclinical research using small and large animal models into clinical practice for the benefit of humans. Research on rodent models has enhanced our understanding of complex pathophysiology, thus providing potential translational pathways. However, the success of translating drugs from pre-clinical to clinical therapy has been poor, partly due to the choice of experimental model. The sheep model, in particular, is being increasingly applied to the field of biomedical research and is arguably one of

APA, Harvard, Vancouver, ISO, and other styles

18

Reinhardt, Christoph, and Heiko Rühl. "Animal and Cellular Models in Thrombosis and Hemostasis." Hämostaseologie 43, no. 05 (2023): 319–20. http://dx.doi.org/10.1055/a-2031-7975.

Full text

Abstract:

Abstract Standardized In Vitro and In Vivo Model Systems to Simplify Complexity—That's How We Learn The discovery of new target molecules and translational progress in the development and refinement of antithrombotic therapies as well as the improved treatment of bleeding disorders strongly relies on standardized ex vivo and in vivo models that closely resemble the respective human pathologies. The standardization of these models requires sound training in specialized hemostasis and thrombosis research laboratories as well as a consistent daily routine. In this theme issue of Hämostaseologie—P

APA, Harvard, Vancouver, ISO, and other styles

19

Gonzalez, Liara M., Adam J. Moeser, and Anthony T. Blikslager. "Porcine models of digestive disease: the future of large animal translational research." Translational Research 166, no. 1 (2015): 12–27. http://dx.doi.org/10.1016/j.trsl.2015.01.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Ziegler, Amanda, Liara Gonzalez, and Anthony Blikslager. "Large Animal Models: The Key to Translational Discovery in Digestive Disease Research." Cellular and Molecular Gastroenterology and Hepatology 2, no. 6 (2016): 716–24. http://dx.doi.org/10.1016/j.jcmgh.2016.09.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Han, Sufang, Xing Li, Zhifeng Xiao, and Jianwu Dai. "Complete canine spinal cord transection model: a large animal model for the translational research of spinal cord regeneration." Science China Life Sciences 61, no. 1 (2017): 115–17. http://dx.doi.org/10.1007/s11427-017-9049-y.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Milla, Juan Martinez, Carlos Galan-Arriola, Manuel Lobo Gonzalez, et al. "CHARACTERIZATION BY MULTIMODALITY IMAGING OF A LARGE ANIMAL MODEL OF ISCHEMIC DILATED CARDIOMYOPATHY WITH TRANSLATIONAL IMPLICATIONS." Journal of the American College of Cardiology 73, no. 9 (2019): 759. http://dx.doi.org/10.1016/s0735-1097(19)31367-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Etra, Joanna W., Katherine E. Cilwa, Georg J. Furtmuller, et al. "Noninvasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model." Journal of the American College of Surgeons 227, no. 4 (2018): S254. http://dx.doi.org/10.1016/j.jamcollsurg.2018.07.520.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Nürnberger, S. "TRANSLATIONAL MODELS FOR OSTEOARTHRITIS: SPEEDING UP FROM BENCH TO BEDSIDE." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 144. http://dx.doi.org/10.1302/1358-992x.2024.2.144.

Full text

Abstract:

Translational models for OA have used a variety of small (mouse, rat) and large (sheep, pig) animal models to evaluate the efficacy of a specific therapy. Clinical trials based on the results of these animal models have yielded mixed results with respect to the treatment of the disease. Due to greater stringency in EU regulations in the use of animal models for research, ex vivo models of OA (e.g. cartilage explants, bioreactors) are being developed to mimic human joint motion as well as the inflammatory milieu (e.g. IL-1β) that can be used to understand efficacy of therapy in a physiological

APA, Harvard, Vancouver, ISO, and other styles

25

Osum, Sara H., Adrienne L. Watson, and David A. Largaespada. "Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1." International Journal of Molecular Sciences 22, no. 4 (2021): 1954. http://dx.doi.org/10.3390/ijms22041954.

Full text

Abstract:

Animal models are crucial to understanding human disease biology and developing new therapies. By far the most common animal used to investigate prevailing questions about human disease is the mouse. Mouse models are powerful tools for research as their small size, limited lifespan, and defined genetic background allow researchers to easily manipulate their genome and maintain large numbers of animals in general laboratory spaces. However, it is precisely these attributes that make them so different from humans and explains, in part, why these models do not accurately predict drug responses in

APA, Harvard, Vancouver, ISO, and other styles

26

Albertine, Kurt H. "Utility of large-animal models of BPD: chronically ventilated preterm lambs." American Journal of Physiology-Lung Cellular and Molecular Physiology 308, no. 10 (2015): L983—L1001. http://dx.doi.org/10.1152/ajplung.00178.2014.

Full text

Abstract:

This paper is focused on unique insights provided by the preterm lamb physiological model of bronchopulmonary dysplasia (BPD). Connections are also made to insights provided by the former preterm baboon model of BPD, as well as to rodent models of lung injury to the immature, postnatal lung. The preterm lamb and baboon models recapitulate the clinical setting of preterm birth and respiratory failure that require prolonged ventilation support for days or weeks with oxygen-rich gas. An advantage of the preterm lamb model is the large size of preterm lambs, which facilitates physiological studies

APA, Harvard, Vancouver, ISO, and other styles

27

Howland, David, Zdenka Ellederova, Neil Aronin, et al. "Large Animal Models of Huntington’s Disease: What We Have Learned and Where We Need to Go Next." Journal of Huntington's Disease 9, no. 3 (2020): 201–16. http://dx.doi.org/10.3233/jhd-200425.

Full text

Abstract:

Genetically modified rodent models of Huntington’s disease (HD) have been especially valuable to our understanding of HD pathology and the mechanisms by which the mutant HTT gene alters physiology. However, due to inherent differences in genetics, neuroanatomy, neurocircuitry and neurophysiology, animal models do not always faithfully or fully recapitulate human disease features or adequately predict a clinical response to treatment. Therefore, conducting translational studies of candidate HD therapeutics only in a single species (i.e. mouse disease models) may not be sufficient. Large animal

APA, Harvard, Vancouver, ISO, and other styles

28

Meng, Xiangbo, Reihane Ziadlou, Sibylle Grad, et al. "Animal Models of Osteochondral Defect for Testing Biomaterials." Biochemistry Research International 2020 (January 28, 2020): 1–12. http://dx.doi.org/10.1155/2020/9659412.

Full text

Abstract:

The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics. Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue engineering, it is critical to establish an appropriate animal model to evaluate the degradability, biocompatibility, and interaction of implanted biomaterials with host bone/cartilage tissues for OCD repair in vivo. Currently, model animals that are commonly deployed to create osteochondral lesions range from rats, rabbits, dogs, pigs, goats, and sheep horses to nonhuman primates. It is essential to understand the advan

APA, Harvard, Vancouver, ISO, and other styles

29

Wang, Dean, Deborah Wen, and Soong Joon Lee. "EP4.9 An Open Anterolateral Surgical Approach to the Yucatan Minipig Hip for Translational Large Animal Research." Journal of Hip Preservation Surgery 12, Supplement_1 (2025): i81. https://doi.org/10.1093/jhps/hnaf011.262.

Full text

Abstract:

Abstract Introduction: Translational animal models are critical tools for investigating new biologic therapies in preclinical studies before progression to human clinical trials. The Yucatan minipig, which has been widely used in translational orthopaedic research, is an ideal large animal model because 1) its joint loading biomechanics better simulate the adult human condition compared to other large animals, 2) its sufficient cartilage thickness (1-3 mm), and 3) it exhibits limited intrinsic healing capacity of chondral defects. The purpose of this study was to describe an anterolateral surg

APA, Harvard, Vancouver, ISO, and other styles

30

Lu, Peng, Chhinder P. Sodhi, Hongpeng Jia, et al. "Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges." American Journal of Physiology-Gastrointestinal and Liver Physiology 306, no. 11 (2014): G917—G928. http://dx.doi.org/10.1152/ajpgi.00422.2013.

Full text

Abstract:

Necrotizing enterocolitis is the leading cause of morbidity and mortality from gastrointestinal disease in premature infants and is characterized by initial feeding intolerance and abdominal distention followed by the rapid progression to coagulation necrosis of the intestine and death in many cases. Although the risk factors for NEC development remain well accepted, namely premature birth and formula feeding, the underlying mechanisms remain incompletely understood. Current thinking indicates that NEC develops in response to an abnormal interaction between the mucosal immune system of the pre

APA, Harvard, Vancouver, ISO, and other styles

31

Smith, Patrick A., James P. Stannard, Ferris M. Pfeiffer, Keiichi Kuroki, Chantelle C. Bozynski, and James L. Cook. "Suspensory Versus Interference Screw Fixation for Arthroscopic Anterior Cruciate Ligament Reconstruction in a Translational Large-Animal Model." Arthroscopy: The Journal of Arthroscopic & Related Surgery 32, no. 6 (2016): 1086–97. http://dx.doi.org/10.1016/j.arthro.2015.11.026.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Nguyen, Patricia K., and Joseph C. Wu. "Large Animal Models of Ischemic Cardiomyopathy: Are They Enough to Bridge the Translational Gap?" Journal of Nuclear Cardiology 22, no. 4 (2015): 666–72. http://dx.doi.org/10.1007/s12350-015-0078-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Starbæk, Sofie M. R., Louise Brogaard, Harry D. Dawson, et al. "Animal Models for Influenza A Virus Infection Incorporating the Involvement of Innate Host Defenses: Enhanced Translational Value of the Porcine Model." ILAR Journal 59, no. 3 (2018): 323–37. http://dx.doi.org/10.1093/ilar/ily009.

Full text

Abstract:

Abstract Influenza is a viral respiratory disease having a major impact on public health. Influenza A virus (IAV) usually causes mild transitory disease in humans. However, in specific groups of individuals such as severely obese, the elderly, and individuals with underlying inflammatory conditions, IAV can cause severe illness or death. In this review, relevant small and large animal models for human IAV infection, including the pig, ferret, and mouse, are discussed. The focus is on the pig as a large animal model for human IAV infection as well as on the associated innate immune response. Pi

APA, Harvard, Vancouver, ISO, and other styles

34

Scarano, Antonio, Ahmad G. A. Khater, Sergio Alexandre Gehrke, Francesco Inchingolo, and Sergio Rexhep Tari. "Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades." Journal of Functional Biomaterials 15, no. 4 (2024): 83. http://dx.doi.org/10.3390/jfb15040083.

Full text

Abstract:

Dental implants and bone augmentation are among dentistry’s most prevalent surgical treatments; hence, many dental implant surfaces and bone grafts have been researched to improve bone response. Such new materials were radiologically, histologically, and histomorphometrically evaluated on animals before being used on humans. As a result, several studies used animals to evaluate novel implant technologies, biocompatibility, surgical techniques, and osseointegration strategies, as preclinical research on animal models is essential to evaluate bioactive principles (on cells, compounds, and implan

APA, Harvard, Vancouver, ISO, and other styles

35

La Mantia, Debora, Chiara Bernardini, Augusta Zannoni, et al. "Efficacy of Stem Cell Therapy in Large Animal Models of Ischemic Cardiomyopathies: A Systematic Review and Meta-Analysis." Animals 12, no. 6 (2022): 749. http://dx.doi.org/10.3390/ani12060749.

Full text

Abstract:

Stem-cell therapy provides a promising strategy for patients with ischemic heart disease. In recent years, numerous studies related to this therapeutic approach were performed; however, the results were often heterogeneous and contradictory. For this reason, we conducted a systematic review and meta-analysis of trials, reporting the use of stem-cell treatment against acute or chronic ischemic cardiomyopathies in large animal models with regard to Left Ventricular Ejection Fraction (LVEF). The defined research strategy was applied to the PubMed database to identify relevant studies published fr

APA, Harvard, Vancouver, ISO, and other styles

36

Herrmann, Andrea M., Stephan Meckel, Matthew J. Gounis, et al. "Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations." Journal of Cerebral Blood Flow & Metabolism 39, no. 3 (2019): 375–94. http://dx.doi.org/10.1177/0271678x19827446.

Full text

Abstract:

Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this

APA, Harvard, Vancouver, ISO, and other styles

37

Ferreira, Monica, Vera Geraldes, Ana Clara Felix, Mario Oliveira, Sergio Laranjo, and Isabel Rocha. "Advancing Atrial Fibrillation Research: The Role of Animal Models, Emerging Technologies and Translational Challenges." Biomedicines 13, no. 2 (2025): 307. https://doi.org/10.3390/biomedicines13020307.

Full text

Abstract:

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, presenting a significant global healthcare challenge due to its rising incidence, association with increased morbidity and mortality, and economic burden. This arrhythmia is driven by a complex interplay of electrical, structural, and autonomic remodelling, compounded by genetic predisposition, systemic inflammation, and oxidative stress. Despite advances in understanding its pathophysiology, AF management remains suboptimal, with ongoing debates surrounding rhythm control, rate control, and anticoagulation strategies

APA, Harvard, Vancouver, ISO, and other styles

38

Riedl, Moritz, Markus Rupp, Nike Walter, et al. "Practical Relevance of Institutional Guidelines in Translational Large Animal Studies of Cartilage Repair—A Multidisciplinary Survey." Medicina 58, no. 12 (2022): 1834. http://dx.doi.org/10.3390/medicina58121834.

Full text

Abstract:

Background and Objective: Translational large animal models are inevitable to transfer cartilage repair methods into clinical practice. Guidelines for these trials have been published by guiding agencies (FDA, ASTM, EMEA) including recommendations for study descriptors and study outcomes. However, practical adherence to these recommendations is not achieved in all aspects. This study includes an assessment of the recommended aspects regarding practical relevance in large animal models for cartilage repair by professionals in the field. Materials and Methods: In an online based survey, 11 aspec

APA, Harvard, Vancouver, ISO, and other styles

39

Barosova, Romana, Eva Baranovicova, Juliana Hanusrichterova, and Daniela Mokra. "Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics." International Journal of Molecular Sciences 25, no. 1 (2023): 459. http://dx.doi.org/10.3390/ijms25010459.

Full text

Abstract:

Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the treatment. Therefore, precise diagnostics represent a fundamental condition for effective therapy. In the diagnostic process, metabolomic approaches have been increasingly used, providing detailed information on the metabolic alterations associated with human asthma. Further information is brought by metabolomic analysis of samples obtained from anima

APA, Harvard, Vancouver, ISO, and other styles

40

Galuta, Ahmad, and Eve Tsai. "From Zero to Neuro-Reprogramming: Innovations in Translational Neuroregenerative Medicine." University of Ottawa Journal of Medicine 9, no. 1 (2019): 54–60. http://dx.doi.org/10.18192/uojm.v9i1.4163.

Full text

Abstract:

Acquiring live human nervous tissue for research presents ethical and technical constraints. As a result, clinicians and scientists resort to using animal models to investigate human neuronal development and degeneration. However, innate species differences in neurobiology have hindered the translation of disease pathologies and development of therapeutic strategies. The discovery of endogenous neural stem cells (NSCs) and their examination has been critical for neuronal development, degeneration and regeneration. NSCs can exist in different developmental stages, embryonic through adult, and p

APA, Harvard, Vancouver, ISO, and other styles

41

Mowes, Anja, Beatriz E. de Jongh, Timothy Cox, Yan Zhu, and Thomas H. Shaffer. "A translational cellular model to study the impact of high-frequency oscillatory ventilation on human epithelial cell function." Journal of Applied Physiology 122, no. 1 (2017): 198–205. http://dx.doi.org/10.1152/japplphysiol.00400.2016.

Full text

Abstract:

High-frequency oscillatory ventilation (HFOV) has been proposed as gentle ventilation strategy to prevent lung injury in the preterm infant. High-frequency jet ventilation leads to dimensional and mechanical airway deformation in animal airway models, which is consistent with translational studies demonstrating the impact of oxygen and biophysical stresses on normal airway cellular function. There is an overall paucity of clinical and cellular data on the impact of HFOV on the conducting airway. We developed an innovative method to test the impact of the clinical HFO Ventilator (SensorMedics 3

APA, Harvard, Vancouver, ISO, and other styles

42

Williams, Preston, John Brandenburg, Dennis Q. Truong, et al. "Abstract #136: Translational Neuromodulation of Motor-Output Using Trans-spinal Direct Current Stimulation (tsDCS) in a Large Animal Model." Brain Stimulation 12, no. 2 (2019): e46-e47. http://dx.doi.org/10.1016/j.brs.2018.12.143.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Huang, Lan, Fengyan Zhao, Yi Qu, Li Zhang, Yan Wang, and Dezhi Mu. "Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes." Reviews in the Neurosciences 28, no. 1 (2017): 31–43. http://dx.doi.org/10.1515/revneuro-2016-0022.

Full text

Abstract:

AbstractHypoxic-ischemic encephalopathy (HIE), a serious disease leading to neonatal death, is becoming a key area of pediatric neurological research. Despite remarkable advances in the understanding of HIE, the explicit pathogenesis of HIE is unclear, and well-established treatments are absent. Animal models are usually considered as the first step in the exploration of the underlying disease and in evaluating promising therapeutic interventions. Various animal models of HIE have been developed with distinct characteristics, and it is important to choose an appropriate animal model according

APA, Harvard, Vancouver, ISO, and other styles

44

Hiemstra, Jessica A., Adam B. Veteto, Michelle D. Lambert, et al. "Chronic low-intensity exercise attenuates cardiomyocyte contractile dysfunction and impaired adrenergic responsiveness in aortic-banded mini-swine." Journal of Applied Physiology 124, no. 4 (2018): 1034–44. http://dx.doi.org/10.1152/japplphysiol.00840.2017.

Full text

Abstract:

Exercise improves clinical outcomes in patients diagnosed with heart failure with reduced ejection fraction (HFrEF), in part via beneficial effects on cardiomyocyte Ca2+ cycling during excitation-contraction coupling (ECC). However, limited data exist regarding the effects of exercise training on cardiomyocyte function in patients diagnosed with heart failure with preserved ejection fraction (HFpEF). The purpose of this study was to investigate cardiomyocyte Ca2+ handling and contractile function following chronic low-intensity exercise training in aortic-banded miniature swine and test the hy

APA, Harvard, Vancouver, ISO, and other styles

45

Pilz, Patrick M., Jennifer E. Ward, Wei-Ting Chang, et al. "Large and Small Animal Models of Heart Failure With Reduced Ejection Fraction." Circulation Research 130, no. 12 (2022): 1888–905. http://dx.doi.org/10.1161/circresaha.122.320246.

Full text

Abstract:

Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions that results in structural and functional remodeling leading to subsequent impairment of cardiac function, including either systolic dysfunction, diastolic dysfunction, or both. Several factors chronically lead to HF, including cardiac volume and pressure overload that may result from hypertension, valvular lesions, acute, or chronic ischemic injuries. Major forms of HF include hypertrophic, dilated, and restrictive cardiomyopathy. The severity of cardiomyopathy can be impacted by other comorbidities such a

APA, Harvard, Vancouver, ISO, and other styles

46

Oliveira, M. T., S. Lucena, J. Potes, et al. "Ex Vivo Model for Percutaneous Vertebroplasty." Key Engineering Materials 631 (November 2014): 408–13. http://dx.doi.org/10.4028/www.scientific.net/kem.631.408.

Full text

Abstract:

The testing of novel biomaterials for percutaneous vertebroplasty depends on suitable animal models. The aim of this study was to develop ex vivo a reproducible and feasible model of percutaneous vertebroplasty, for ulterior application in vivo. A large animal model was used (Merino sheep), due to its translational properties. Vertebroplasty was performed under tactile and fluoroscopic control, through a bilateral modified parapedicular access in lumbar vertebrae (n=12). Care was taken in order to avoid disruption of the vertebral foramen. The average defect volume was 1234±240 mm3. This mean

APA, Harvard, Vancouver, ISO, and other styles

47

Simpson, S., L. Gonzalez, J. Chung, A. Blikslager, S. Magness, and J. Piedrahita. "27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS." Reproduction, Fertility and Development 28, no. 2 (2016): 143. http://dx.doi.org/10.1071/rdv28n2ab27.

Full text

Abstract:

Murine models for the study of adult stem cell populations have broadened the understanding of previously uncharacterized stem cell niches. The development of murine reporter lines for the leucine-rich repeat-containing G-protein-coupled receptor-5 (Lgr5) has highlighted the importance of this gene as a stem cell marker in the stomach, intestine, hair follicle, liver, and kidney in mice. These models however have significant limitations in terms of translational applications because of anatomical and physiological differences between humans and mice. In order to overcome these limitations, we

APA, Harvard, Vancouver, ISO, and other styles

48

Kremen, Thomas J., Tina Stefanovic, Wafa Tawackoli, et al. "A Translational Porcine Model for Human Cell–Based Therapies in the Treatment of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Injury." American Journal of Sports Medicine 48, no. 12 (2020): 3002–12. http://dx.doi.org/10.1177/0363546520952353.

Full text

Abstract:

Background: There is a high incidence of posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) injury, and these injuries represent an enormous health care economic burden. In an effort to address this unmet clinical need, there has been increasing interest in cell-based therapies. Purpose: To establish a translational large animal model of PTOA and demonstrate the feasibility of intra-articular human cell–based interventions. Study Design: Descriptive laboratory study. Methods: Nine Yucatan mini-pigs underwent unilateral ACL transection and were monitored for up to 12 wee

APA, Harvard, Vancouver, ISO, and other styles

49

Boltze, Johannes, Annette Förschler, Björn Nitzsche, et al. "Permanent Middle Cerebral Artery Occlusion in Sheep: A Novel Large Animal Model of Focal Cerebral Ischemia." Journal of Cerebral Blood Flow & Metabolism 28, no. 12 (2008): 1951–64. http://dx.doi.org/10.1038/jcbfm.2008.89.

Full text

Abstract:

As effective stroke treatment by thrombolysis is bound to a narrow time window excluding most patients, numerous experimental treatment strategies have been developed to gain new options for stroke treatment. However, all approaches using neuroprotective agents that have been successfully evaluated in rodents have subsequently failed in clinical trials. Existing large animal models are of significant scientific value, but sometimes limited by ethical drawbacks and mostly do not allow for long-term observation. In this study, we are introducing a simple, but reliable stroke model using permanen

APA, Harvard, Vancouver, ISO, and other styles

50

Arruda, Valder R., Hansell H. Stedman, Timothy C. Nichols, et al. "Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model." Blood 105, no. 9 (2005): 3458–64. http://dx.doi.org/10.1182/blood-2004-07-2908.

Full text

Abstract:

AbstractIn earlier work, we showed that adeno-associated virus–mediated delivery of a Factor IX gene to skeletal muscle by direct intramuscular injection resulted in therapeutic levels of circulating Factor IX in mice. However, achievement of target doses in humans proved impractical because of the large number of injections required. We used a novel intravascular delivery technique to achieve successful transduction of extensive areas of skeletal muscle in a large animal with hemophilia. We provide here the first report of long-term (&gt; 3 years, with observation ongoing), robust Factor

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!