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Relevant bibliographies by topics / Translational psychiatry / Dissertations / Theses

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Dissertations / Theses on the topic 'Translational psychiatry'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Cahill, John. "Using the concept of complexity to guide translational research in psychiatry." Thesis, University of Huddersfield, 2018. http://eprints.hud.ac.uk/id/eprint/34543/.

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The presented work unites several distinct lines of research, asserting that the broader construct of complexity (with its various connotations) may be uniquely relevant and informative to our understanding and management of psychotic disorders. Part 1 outlines the candidate’s contributions to the development of EEG methodology in clinical populations in an effort to most directly capture neural noise and complexity. The advent of oscillatory analysis facilitated the study of ongoing background activity of the EEG. Further exploration of this background activity demonstrated that increased neu

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2

Napolitano, Antonio. "Neurotransmitter profiling with high and ultra-high field magnetic resonance spectroscopy : optimization for clinical and translational studies in schizophrenia." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/28305/.

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Growing interest in the research community has been shown in clinical neuroscience to assess neurotransmitter profiling both in healthy and diseased subjects. A large body of research in this field focuses on schizophrenia to characterise its glutamatergic level according to the most recent hypothesis of NMDA (N-Methyl-D-aspartic acid) receptors hypofunction. Magnetic Resonance Spectroscopy (MRS) is able to detect some of the most common neurotransmitters but a number of issues, such as low signal to noise ratio (SNR), spectra overlapping and line broadening prevents MRS from being clinically

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3

Steventon, Jessica. "Characterising the structural brain changes in Huntington's disease using translational neuroimaging." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/71204/.

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This thesis examined the macro-structural and micro-structural changes in Huntington’s disease (HD) in order to improve understanding of the temporal and spatial patterns of neurodegeneration, and the functional relevance of these changes. Translational techniques were employed using genetic mouse models of HD in combination with a patient cohort to examine grey and white matter changes with a particular focus on white matter microstructure. In the patient cohort, the cognitive profile was examined using a cognitive battery not before applied in HD. Specific deficits were found in set-shifting

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4

Smalley, Daniel S. "Translational control of epidermal growth factor receptor in neurodegenerative diseases." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43474/.

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Epidermal growth factor receptor (EGFR) is a key modulator of a number of cellular processes such as cell fate, proliferation, migration, and apoptosis. The EGFR gene is commonly amplified in a number of cancers and EGFR has been implicated in Alzheimer’s disease, but its role in this context is uncertain. An internal ribosome entry site (IRES) within the EGFR 5’untranslated region (UTR) has been previously discovered which maintains EGFR expression under hypoxic conditions and has a high requirement for the eukaryotic initiation factor (eIF) 4A helicase. Requirement for eIF4A suggests that th

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5

Smith, Brooke M. "Effects of Differential Rates of Alternative Reinforcement on Resurgence of Human Behavior: A Translational Model of Relapse in the Anxiety Disorders." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4511.

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Behavioral and cognitive-behavioral psychotherapies utilizing exposure are considered the gold standard in anxiety disorder treatments. Despite their success, relapse remains problematic, especially over long-term follow up periods. Basic researchers traditionally conceptualize the mechanism of exposure as Pavlovian extinction, but this may overlook the important role of operant processes in the treatment and relapse of anxiety. Resurgence, in which a previously extinguished behavior returns following the extinction of another behavior that has replaced it, is a promising model of operant rela

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6

Yamashita, Ayumu. "Functional magnetic resonance imaging-based methods for translational research of psychiatric disorders." Kyoto University, 2019. http://hdl.handle.net/2433/242444.

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7

Drennan, Gerard. "Aspects of translation in psychological and psychiatric cross-cultural research." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/13548.

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This study investigates the process of translating English-language questionnaires and interview formats into Black African languages. The details of translation are invariably glossed in reports and publications on the use of translated psychological and psychiatric instruments. This results in a lack of clarity on how these translated instruments are produced and what difficulties are encountered in their development and use, suggesting the need for a detailed examination of the translation process. Researchers working in South Africa were interviewed with a semi-structured format in 1989. E

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8

Slabbert, Meggan. "Three's a crowd: the process of triadic translation in a South African psychiatric institution." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1002565.

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Mental health care in South Africa has long been governed by inequalities (Foster & Swartz, 1997). During apartheid, those who did not speak English and Afrikaans could not access mental health services in the same way as those who did (Foster & Swartz, 1997). One main reason for this is the majority of mental health practitioners could not, and were not required to speak languages other than English and Afrikaans (Swartz, 1991). The South African mental health literature suggests that language and communication must be prioritised if there is to be an improvement in mental health care service

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9

Bittlinger, Timon Merlin Miguel [Verfasser]. "Ethical aspects of psychiatric neurosurgery: evidence, translation, and public attitudes / Timon Merlin Miguel Bittlinger." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1218076186/34.

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10

Bareis, Natalie. "Person-Centered Treatment to Optimize Psychiatric Medication Adherence." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4743.

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Objectives: Adherence to psychotropic medication is poor among individuals with bipolar disorder (BD). To understand treatment experiences and associated adherence among these individuals, we developed a novel construct of Clinical Net Benefit (CNB) using psychiatric symptoms, adverse effects and overall functioning assessments. We tested whether adherence differed across classes of CNB, whether individuals transitioned between classes over time, and whether these transitions were differentially associated with adherence. Methods: Data come from individuals aged 18+ during five years of the Sy

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11

Bourdon, Jessica L. "Translational insights into the genetic etiology of mental health disorders: Examining risk factor models, neuroimaging, and current dissemination practices." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5734.

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Psychiatric genetics is a basic science field that has potential for practical application and effective translation. To date, translational frameworks utilized by this field have been linear (e.g., sequential) in nature, focusing on molecular genetic information. It is proposed that non-linear (e.g., socio-ecological) frameworks are a better way to immediately translate non-molecular genetic information. This dissertation explored the translation of psychiatric genetic information in two ways. First, a survey was sent to academic stakeholders to assess the state of the science regarding the t

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12

Burton, Donna L. "School Mental Health: Views of Services Integration and Attitudes Toward Evidence-based." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4647.

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ABSTRACT Purpose of the study. Through secondary data analysis of results from the School Mental Health Services Integration Survey (SMHSIS), this study describes indicators of school mental health integration preparedness, including role identification, willingness to engage in tasks associated with mental health services integration and implementation facilitators. The study also investigated the utility of a modified version of the Evidence-Based Practice Attitude Scale (EBPAS) for use with school staff. Study rationale. With as many as 20% of children meeting criteria for mental disorder

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13

Dutt, Mohini D. "Adverse Childhood Experiences and its Association with Cognitive Impairment in Non- Patient Older Population." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/7019.

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This study explores cognitive impairment and its correlation to early- life adverse experiences in non-patient population between the ages of 50 to 65. This developmental approach and observational study design explores cognition in pre-clinical Alzheimer’s disease (AD). Using a standardized neuropsychological instrument, the Montreal Cognitive Assessment (MoCA) and clinically administered questionnaire, the ACE (Adverse Childhood Experiences), I hypothesized that participants with high ACE scores will inversely have low MoCA scores. My goal was to use a multiple linear reg

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14

Amad, Ali. "Étude de la plasticité cérébrale en psychiatrie à partir de plusieurs modèles pathologiques : le trouble de personnalité borderline et les hallucinations." Thesis, Lille 2, 2014. http://www.theses.fr/2014LIL2S034/document.

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La neuroplasticité (NP), définie comme la capacité du système nerveux à s’adapter aux changements environnementaux, est un phénomène intrinsèque au fonctionnement cérébral et essentiel à son homéostasie. La NP est par définition impliquée dans toutes les maladies du cerveau dont les troubles psychiatriques. Différents troubles psychiatriques peuvent être utilisés comme autant de modèles pour étudier les différentes facettes de la NP de façon translationnelle : du moléculaire au comportemental permettant alors d'améliorer la compréhension de la régulation de la NP et de son implication dans l'é

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15

Mamdani, Mohammed. "A Systems Biology Approach to Detect eQTLs Associated with miRNA and mRNA Co-expression Networks in the Nucleus Accumbens of Chronic Alcoholic Patients." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4313.

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Alcohol Dependence (AD) is a chronic substance use disorder with moderate heritability (60%). Linkage and genome-wide association studies (GWAS) have implicated a number of loci; however, the molecular mechanisms underlying AD are unclear. Advances in systems biology allow genome-wide expression data to be integrated with genetic data to detect expression quantitative trait loci (eQTL), polymorphisms that regulate gene expression levels, influence phenotypes and are significantly enriched among validated genetic signals for many commonly studied traits including AD. We integrated genome-wide m

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16

Mogos, Mulubrhan Fisseha. "Translation and Adaptation of the Center for Epidemiologic Studies-Depression (CES-D) Scale Into Tigrigna Language for Tigrigna Speaking Eritrean Immigrants in the United States." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3251.

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ABSTRACT Depression is one of the oldest known mental health conditions. It is acknowledged to be a global health problem that affects people from any culture or ethnic group. The prevalence of depression widely varied across countries and cultures. The cross-cultural relevance of the concept of depression, its screening or diagnosis, and cultural equivalence of items used to measure symptoms of depression has been area of research interest. Differences in prevalence rates in depression have been suggested as being due to research artifacts, such as use of instrument developed for one culture

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17

Montagni, Ilaria. "Mental Health in Europe: the need for a common language, standard classification criteria and official communication. Four studies about communication in Mental Health." Doctoral thesis, 2014. http://hdl.handle.net/11562/698561.

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Tra i principali obiettivi della strategia attuale della Commissione Europea 'Together for Health: A Strategic Approach for the EU 2008-2013' vi è la necessità di produrre e diffondere i prodotti della ricerca in materia di Salute. Comunicare le scoperte scientifiche nel campo della Salute in generale e della Salute Mentale in particolare è di primaria importanza . Tale processo di comunicazione coinvolge ricercatori e pubblico - inclusi a) specialisti e personale medico , b ) policy-makers, c ) giornalisti, e d ) pubblico in generale - e in realtà questo è uno dei principali compiti dei ricer

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18

Lamoureux, Danielle. "La psychanalyse des enfants : étude comparée des traductions de deux oeuvres fondatrices, suivie d'un glossaire." Thèse, 2008. http://hdl.handle.net/1866/8165.

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19

Ditton-Phare, Philippa. "Improving doctor-patient communication: evaluation of a communication skills training program for psychiatry." Thesis, 2021. http://hdl.handle.net/1959.13/1423768.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Doctor-patient communication is an area of significant focus. For decades, patients experiencing severe mental illness (e.g., schizophrenia), along with their families and carers, have expressed a desire for better communication and information about illness diagnosis, prognosis and treatment. Evidence from other medical specialties (e.g., oncology) show that specific and targeted communication skills can be acquired through communication skills training (CST), translate to clinical practice, and improve patient outcomes. However, in psychiatr

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20

Liao, Hsiu-Chuan, and 廖秀娟. "A Study of Chinese Terminology Translation of Popular Science Publications in Taiwan in Psychiatry –With suicide behaviors terminology an example." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/89184015621229289389.

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碩士<br>長榮大學<br>翻譯研究所(在職專班)<br>96<br>With the development of technology, individuals have encountered higher and higher pressures in daily life; the demand for information related to psychiatry has increased dramatically. However, the inconsistent translation of psychiatry terminology makes it very difficult for general public to read and to understand popular science publications in psychiatry. The purpose of this thesis is to establish the most referable criteria, which has integrated the expertise of psychiatry and the reader-centered translation theory, for translation of popular science p

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21

Kästner, Anne. "The influence of common genetic variations in candidate genes on neuropsychiatric phenotypes." Thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BB0B-B.

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