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Journal articles on the topic 'Translocation (Genetics)'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Tennyson, Rachel B., Nathalie Ebran, Anissa E. Herrera, and Janet E. Lindsley. "A Novel Selection System for Chromosome Translocations in Saccharomyces cerevisiae." Genetics 160, no. 4 (April 1, 2002): 1363–73. http://dx.doi.org/10.1093/genetics/160.4.1363.

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Abstract Chromosomal translocations are common genetic abnormalities found in both leukemias and solid tumors. While much has been learned about the effects of specific translocations on cell proliferation, much less is known about what causes these chromosome rearrangements. This article describes the development and use of a system that genetically selects for rare translocation events using the yeast Saccharomyces cerevisiae. A translocation YAC was created that contains the breakpoint cluster region from the human MLL gene, a gene frequently involved in translocations in leukemia patients,

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2

Welker, D. L., and K. L. Williams. "TRANSLOCATIONS IN DICTYOSTELIUM DISCOIDEUM." Genetics 109, no. 2 (February 1, 1985): 341–64. http://dx.doi.org/10.1093/genetics/109.2.341.

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ABSTRACT Fourteen translocations of independent origin were identified in Dictyostelium discoideum on the basis of segregation anomalies of diploids heterozygous for these chromosome rearrangements, all of which led to the cosegregation of unlinked markers. Many of these translocations were discovered in strains mutagenized with MNNG or in strains carrying mutations affecting DNA repair; however, spontaneous translocations were also obtained. Haploid mitotic recombinants of the rearranged linkage groups were produced from diploids heterozygous for the translocations at frequencies of up to 5%

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3

McKim, K. S., A. M. Howell, and A. M. Rose. "The effects of translocations on recombination frequency in Caenorhabditis elegans." Genetics 120, no. 4 (December 1, 1988): 987–1001. http://dx.doi.org/10.1093/genetics/120.4.987.

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Abstract In the nematode Caenorhabditis elegans, recombination suppression in translocation heterozygotes is severe and extensive. We have examined the meiotic properties of two translocations involving chromosome I, szT1(I;X) and hT1(I;V). No recombination was observed in either of these translocation heterozygotes along the left (let-362-unc-13) 17 map units of chromosome I. Using half-translocations as free duplications, we mapped the breakpoints of szT1 and hT1. The boundaries of crossover suppression coincided with the physical breakpoints. We propose that DNA sequences at the right end o

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4

Tulay, P., M. Gultomruk, N. Findikli, and M. Bahceci. "Poor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics?" Zygote 23, no. 5 (September 29, 2014): 778–84. http://dx.doi.org/10.1017/s0967199414000422.

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SummaryBalanced reciprocal translocation carriers are usually phenotypically normal. Although the reproductive risk of these carriers varies, they generally have a lower chance to produce normal or balanced gametes. Preimplantation genetic diagnosis (PGD) is offered to these patients to increase their chances of becoming pregnant by selecting a balanced embryo for transfer. This study aimed to analyse the development and the PGD outcome of the embryos obtained from reciprocal translocation carriers focusing on ones with chromosome 10 rearrangements. In total, 27 reciprocal translocation carrie

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5

Leblon, G., D. Zickler, and S. Lebilcot. "MOST UV-INDUCED RECIPROCAL TRANSLOCATIONS IN SORDARIA MACROSPORA OCCUR IN OR NEAR CENTROMERE REGIONS." Genetics 112, no. 2 (February 1, 1986): 183–204. http://dx.doi.org/10.1093/genetics/112.2.183.

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ABSTRACT In fungi, translocations can be identified and classified by the patterns of ascospore abortion in asci from crosses of rearrangement x normal sequence. Previous studies of UV-induced rearrangements in Sordaria macrospora revealed that a major class (called type III) appeared to be reciprocal translocations that were anomalous in producing an unexpected class of asci with four aborted ascospores in bbbbaaaa linear sequence (b = black; a = abortive). The present study shows that the anomalous type III rearrangements are, in fact, reciprocal translocations having both breakpoints within

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6

Vasilevska, M., E. Ivanovska, K. Kubelka Sabit, E. Sukarova-Angelovska, and G. Dimeska. "THE INCIDENCE AND TYPE OF CHROMOSOMAL TRANSLOCATIONS FROM PRENATAL DIAGNOSIS OF 3800 PATIENTS IN THE REPUBLIC OF MACEDONIA." Balkan Journal of Medical Genetics 16, no. 2 (December 1, 2013): 23–28. http://dx.doi.org/10.2478/bjmg-2013-0027.

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ABSTRACT Robertsonian and reciprocal chromosomal translocations are the most frequent type of structural chromosomal aberrations in the human population. We report the frequency and type of detected translocations in 10 years of prenatal diagnosis of 3800 prenatal samples. The materials came from amniocentesis and chorionic villus samples (CVS). We detected seven Robertsonian translocations (0.18%), eight autosomal reciprocal translocations (0.21%) and one sex chromosome translocation (0.03%). The overall frequency of all translocations was 0.42%. Balanced state translocations were 0.29% and t

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7

Yu, Xin, and Abram Gabriel. "Reciprocal Translocations in Saccharomyces cerevisiae Formed by Nonhomologous End Joining." Genetics 166, no. 2 (February 1, 2004): 741–51. http://dx.doi.org/10.1093/genetics/166.2.741.

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Abstract Reciprocal translocations are common in cancer cells, but their creation is poorly understood. We have developed an assay system in Saccharomyces cerevisiae to study reciprocal translocation formation in the absence of homology. We induce two specific double-strand breaks (DSBs) simultaneously on separate chromosomes with HO endonuclease and analyze the subsequent chromosomal rearrangements among surviving cells. Under these conditions, reciprocal translocations via nonhomologous end joining (NHEJ) occur at frequencies of ∼2-7 × 10-5/cell exposed to the DSBs. Yku80p is a component of

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8

McKee, Bruce. "X-4 Translocations and Meiotic Drive in Drosophila melanogaster Males: Role of Sex Chromosome Pairing." Genetics 116, no. 3 (July 1, 1987): 409–13. http://dx.doi.org/10.1093/genetics/116.3.409.

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ABSTRACT Males carrying certain X-4 translocations exhibit strongly skewed sperm recovery ratios. The XP4D half of the translocation disjoins regularly from the Y chromosome and the 4PXD half disjoins regularly from the normal 4. Yet the smaller member of each bivalent is recovered in excess of its pairing partner, apparently due to differential gametic lethality. Chromosome recovery probabilities are multiplicative; the viability of each genotype is the product of the recovery probability of its component chromosomes. Meiotic drive can also be caused by deficiency for X heterochromatin. In(1)

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9

Liu, Hongfang, Bin Mao, Xiaojuan Xu, Lin Liu, Xiaoling Ma, and Xuehong Zhang. "The Effectiveness of Next-Generation Sequencing-Based Preimplantation Genetic Testing for Balanced Translocation Couples." Cytogenetic and Genome Research 160, no. 11-12 (2020): 625–33. http://dx.doi.org/10.1159/000512847.

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The purpose of this study was to evaluate the effectiveness of next-generation sequencing (NGS)-based preimplantation genetic testing (PGT) for balanced translocation carriers to identify normal/balanced blastocysts and to measure pregnancy outcomes following euploid embryo transfer. We enrolled 75 couples with a balanced translocation who underwent 83 PGT cycles (58 cycles for carriers with reciprocal translocations and 25 cycles for carriers with Robertsonian translocations) and 388 blastocysts were diagnosed. Moreover, we transferred single euploid blastocysts through frozen embryo transfer

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10

Schmid, Michael, Claus Steinlein, and Heinz Winking. "Multicolor Spectral Analyses of Mitotic and Meiotic Mouse Chromosomes Involved in Multiple Robertsonian Translocations. I. The CD/Cremona Hybrid Strain." Cytogenetic and Genome Research 147, no. 4 (2015): 253–59. http://dx.doi.org/10.1159/000444597.

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Multicolor spectral analysis (spectral karyotyping) was applied to mitotic and male diakinetic chromosomes of hybrid mice carrying a unique system of 18 autosomal Robertsonian translocation chromosomes with alternating arm homologies. Only the autosomes 19 and the XY sex chromosomes are excluded from these Robertsonian translocations. The translocations, previously identified by conventional banding analyses, could be verified by spectral karyotyping. Besides the Robertsonian translocations, no other interchromosomal rearrangements were detected. In diakineses of male meiosis, the 18 metacentr

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11

Chand, Mahesh Kumar, Vanessa Carle, K. G. Anuvind, and Kayarat Saikrishnan. "DNA-mediated coupling of ATPase, translocase and nuclease activities of a Type ISP restriction-modification enzyme." Nucleic Acids Research 48, no. 5 (January 24, 2020): 2594–603. http://dx.doi.org/10.1093/nar/gkaa023.

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Abstract Enzymes involved in nucleic acid transactions often have a helicase-like ATPase coordinating and driving their functional activities, but our understanding of the mechanistic details of their coordination is limited. For example, DNA cleavage by the antiphage defense system Type ISP restriction-modification enzyme requires convergence of two such enzymes that are actively translocating on DNA powered by Superfamily 2 ATPases. The ATPase is activated when the enzyme recognizes a DNA target sequence. Here, we show that the activation is a two-stage process of partial ATPase stimulation

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12

Kindiger, B., and S. Hamann. "B–A chromosome mediated 3:1 disjunction in heterozygous reciprocal translocations of maize." Genome 35, no. 5 (October 1, 1992): 714–18. http://dx.doi.org/10.1139/g92-110.

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In maize (Zea mays L.), meiotic segregation products of reciprocal translocations are well defined. The predictible meiotic behaviors and products generated by these interchanges allow them to be used as tools to gain basic information in cytogenetics, genetics, and plant breeding. In combining a classic reciprocal translocation with a single B–A chromosome from a tertiary trisomic B–A translocation stock, unique individuals with unusual chromosome karyotypes are generated. In cases where a B–A chromosome was present, the frequency of 3:1 disjunction within the ring of four was increased. In t

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13

Shilenkova, Yulia V., Anna A. Pendina, Irina D. Mekina, Olga A. Efimova, Evgeniia M. Komarova, Elena A. Lesik, Mariia A. Ishchuk, et al. "Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations." Genes 12, no. 1 (December 25, 2020): 18. http://dx.doi.org/10.3390/genes12010018.

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We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus–oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocat

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14

Menges, Eric S. "Restoration demography and genetics of plants: when is a translocation successful?" Australian Journal of Botany 56, no. 3 (2008): 187. http://dx.doi.org/10.1071/bt07173.

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Restorations are complex, often involving restoring ecological processes, vegetation structure, and species’ populations. One component of restorations is translocation of key species. Translocations (introductions, reintroductions, augmentations) are often necessary to recover species diversity and install key species. In this review, I consider the ways translocations have been evaluated at various stages during the process of restoration. Vital rates (survival, growth, fecundity) of propagules (seeds, transplants) are commonly used to evaluate initial success. Transplants usually provide gr

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15

Pazarbasi, A., O. Demirhan, D. Alptekin, Ft Ozgunen, L. Ozpak, Mb Yilmaz, E. Nazlican, N. Tanriverdi, U. Luleyap, and D. Gümürdülü. "INHERITANCE OF A CHROMOSOME 3 AND 21 TRANSLOCATION IN THE FETUSES, WITH ONE ALSO HAVING TRISOMY 21, IN THREE PREGNANCIES IN ONE FAMILY." Balkan Journal of Medical Genetics 16, no. 2 (December 1, 2013): 91–96. http://dx.doi.org/10.2478/bjmg-2013-0039.

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ABSTRACT The majority of chromosome rearrangements are balanced reciprocal and Robertsonian translocations. It is now known that such abnormalities cause no phenotypic effect on the carrier but lead to increased risk of producing unbalanced gametes. Here, we report the inheritance of a translocation between chromosomes 3 and 21 in a family with one of two fetuses with Down Syndrome carrying the same translocation and the other also carrying the same translocation without the additional chromosome 21. Chromosomal analysis from fetal amniotic fluid and peripheral blood lymphocytes from the famil

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16

Cook, Lola, James K. Hartsfield, and Gail H. Vance. "Partners with reciprocal translocations: genetic counseling for the ‘double translocation’." Clinical Genetics 53, no. 5 (April 23, 2008): 403–7. http://dx.doi.org/10.1111/j.1399-0004.1998.tb02754.x.

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17

Leach, R. C., I. S. Dundas, and A. Houben. "Construction of comparative genetic maps of two 4Bs.4Bl-5Rl translocations in bread wheat (Triticum aestivum L.)." Genome 49, no. 7 (July 1, 2006): 729–34. http://dx.doi.org/10.1139/g06-040.

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The physical length of the rye segment of a 4BS.4BL–5RL translocation derived from the Cornell Wheat Selection 82a1-2-4-7 in a Triticum aestivum 'Chinese Spring' background was measured using genomic in situ hybridization (GISH) and found to be 16% of the long arm. The size of this translocation was similar to previously published GISH measurements of another 4BS.4BL–5RL translocation in a Triticum aestivum 'Viking' wheat background. Molecular maps of both 4BS.4BL–5RL translocations for 2 different wheat backgrounds were developed using RFLP analysis. The locations of the translocation breakpo

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18

Uysal, A., A. Uludağ, F. Sılan, N. Erçelen, C. Zafer, and Ö. Özdemir. "Double Translocation: An Interesting Family History." Balkan Journal of Medical Genetics 16, no. 1 (June 1, 2013): 77–80. http://dx.doi.org/10.2478/bjmg-2013-0022.

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Abstract Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner’s karyotype was 45,XY, t(3;18)(q11;ptel)t(13;14)(q10;q10). The same double balanced translocation was found in two others family members.

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19

P. Armstong, Doug, and Ian G. McLean. "New Zealand translocations: theory and practice." Pacific Conservation Biology 2, no. 1 (1995): 39. http://dx.doi.org/10.1071/pc950039.

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One of the most common tools in New Zealand conservation is to translocate species to new locations. There have now been over 400 translocations done for conservation reasons, mainly involving terrestrial birds. Most translocations have been done strictly as management exercises, with little or no reference to theory. Nevertheless, translocations always involve some underlying theory, given that people must inevitably choose among a range of potential translocation strategies. We review theory relevant to translocations in the following areas: habitat requirements, susceptibility to predation,

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20

McClellan, Amie J., and Jeffrey L. Brodsky. "Mutation of the ATP-Binding Pocket of SSA1 Indicates That a Functional Interaction Between Ssa1p and Ydj1p Is Required for Post-translational Translocation Into the Yeast Endoplasmic Reticulum." Genetics 156, no. 2 (October 1, 2000): 501–12. http://dx.doi.org/10.1093/genetics/156.2.501.

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Abstract The translocation of proteins across the yeast ER membrane requires ATP hydrolysis and the action of DnaK (hsp70) and DnaJ homologues. In Saccharomyces cerevisiae the cytosolic hsp70s that promote post-translational translocation are the products of the Ssa gene family. Ssa1p maintains secretory precursors in a translocation-competent state and interacts with Ydj1p, a DnaJ homologue. Although it has been proposed that Ydj1p stimulates the ATPase activity of Ssa1p to release preproteins and engineer translocation, support for this model is incomplete. To this end, mutations in the ATP-

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21

Badaeva, Ekatherina D., Jiming Jiang, and Bikram S. Gill. "Detection of intergenomic translocations with centromeric and noncentromeric breakpoints in Triticum araraticum: mechanism of origin and adaptive significance." Genome 38, no. 5 (October 1, 1995): 976–81. http://dx.doi.org/10.1139/g95-128.

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Triticum araraticum Jakubz. (2n = 4x = 28, AtAtGG), a wild progenitor of the polyploid cultivated wheat T. timopheevii, shows extensive chromosome translocation polymorphism in natural populations from the Middle East and Transcaucasia. From an extensive survey, eight intergenomic translocation types were observed and their breakpoints analyzed by genomic in situ hybridization. The previously reported species-specific 6At–1G–4G cyclic translocation was found in all accessions studied. In four translocation types, the breakpoints were in interstitial regions of chromosomes and the other four ar

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Livingstone, Kevin D., Vincent K. Lackney, James R. Blauth, Rik van Wijk, and Molly Kyle Jahn. "Genome Mapping in Capsicum and the Evolution of Genome Structure in the Solanaceae." Genetics 152, no. 3 (July 1, 1999): 1183–202. http://dx.doi.org/10.1093/genetics/152.3.1183.

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Abstract We have created a genetic map of Capsicum (pepper) from an interspecific F2 population consisting of 11 large (76.2–192.3 cM) and 2 small (19.1 and 12.5 cM) linkage groups that cover a total of 1245.7 cM. Many of the markers are tomato probes that were chosen to cover the tomato genome, allowing comparison of this pepper map to the genetic map of tomato. Hybridization of all tomato-derived probes included in this study to positions throughout the pepper map suggests that no major losses have occurred during the divergence of these genomes. Comparison of the pepper and tomato genetic m

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23

Ghosh, Sharmila, Candice F. Carden, Rytis Juras, Mayra N. Mendoza, Matthew J. Jevit, Caitlin Castaneda, Olivia Phelps, et al. "Two Novel Cases of Autosomal Translocations in the Horse: Warmblood Family Segregating t(4;30) and a Cloned Arabian with a de novo t(12;25)." Cytogenetic and Genome Research 160, no. 11-12 (2020): 688–97. http://dx.doi.org/10.1159/000512206.

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We report 2 novel autosomal translocations in the horse. In Case 1, a breeding stallion with a balanced t(4p;30) had produced normal foals and those with congenital abnormalities. Of his 9 phenotypically normal offspring, 4 had normal karyotypes, 4 had balanced t(4p;30), and 1 carried an unbalanced translocation with tertiary trisomy of 4p. We argue that unbalanced forms of t(4p;30) are more tolerated and result in viable congenital abnormalities, without causing embryonic death like all other known equine autosomal translocations. In Case 2, two stallions produced by somatic cell nuclear tran

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Weber, D., and T. Helentjaris. "Mapping RFLP loci in maize using B-A translocations." Genetics 121, no. 3 (March 1, 1989): 583–90. http://dx.doi.org/10.1093/genetics/121.3.583.

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Abstract Plants hypoploid for specific segments of each of the maize (Zea mays L.) chromosomes were generated using 24 different B-A translocations. Plants carrying each of the B-A translocations were crossed as male parents to inbreds, and sibling progeny hypoploid or not hypoploid for specific chromosomal segments were recovered. Genomic DNAs from the parents, hypoploid progeny, and nonhypoploid (euploid or hyperploid) progeny for each of these B-A translocations were digested with restriction enzymes, electrophoresed in agarose gels, blotted onto reusable nylon membranes, and probed with ni

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Bernd, Karen K., and Bruce D. Kohorn. "Tip Loci: Six Chlamydomonas Nuclear Suppressors That Permit the Translocation of Proteins with Mutant Thylakoid Signal Sequences." Genetics 149, no. 3 (July 1, 1998): 1293–301. http://dx.doi.org/10.1093/genetics/149.3.1293.

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Abstract Mutations within the signal sequence of cytochrome f (cytf) in Chlamydomonas inhibit thylakoid membrane protein translocation and render cells nonphotosynthetic. Twenty-seven suppressors of the mutant signal sequences were selected for their ability to restore photoautotrophic growth and these describe six nuclear loci named tip1 through 6 for thylakoid insertion protein. The tip mutations restore the translocation of cytf and are not allele specific, as they suppress a number of different cytf signal sequence mutations. Tip5 and 2 may act early in cytf translocation, while Tip1, 3, 4

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Ashraf, M., and M. J. Bassett. "Cytogenetic analysis of translocation heterozygosity in the common bean (Phaseolus vulgaris L.)." Canadian Journal of Genetics and Cytology 28, no. 4 (August 1, 1986): 574–80. http://dx.doi.org/10.1139/g86-084.

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Twelve semisterile lines of Phaseolus vulgaris L. (2n = 22) were reported previously by this laboratory. Here we verify through cytological investigations that 5 of the 12 stocks are indeed chromosome translocations. Cytological analysis of a half diallel set of crosses indicates that these five stocks involve eight different chromosomes in reciprocal translocations. Pollen and ovule abortion rates increase with the increasing number of interchanges in a stock. Cytological behavior and morphological abnormalities with respect to pollen and ovule abortion produced by translocation heterozygosit

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Adames, K. A., Jocelyn Gawne, Chantal Wicky, Fritz Müller, and Ann M. Rose. "Mapping a Telomere Using the Translocation eT1(III;V) in Caenorhabditis elegans." Genetics 150, no. 3 (November 1, 1998): 1059–66. http://dx.doi.org/10.1093/genetics/150.3.1059.

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Abstract In Caenorhabditis elegans, individuals heterozygous for a reciprocal translocation produce reduced numbers of viable progeny. The proposed explanation is that the segregational pattern generates aneuploid progeny. In this article, we have examined the genotype of arrested embryonic classes. Using appropriate primers in PCR amplifications, we identified one class of arrested embryo, which could be readily recognized by its distinctive spot phenotype. The corresponding aneuploid genotype was expected to be lacking the left portion of chromosome V, from the eT1 breakpoint to the left (un

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Uehara, Erika, Atsushi Hattori, Hirohito Shima, Akira Ishiguro, Yu Abe, Tsutomu Ogata, Eishin Ogawa, and Maki Fukami. "Unbalanced Y;7 Translocation between Two Low-Similarity Sequences Leading to SRY-Positive 45,X Testicular Disorders of Sex Development." Cytogenetic and Genome Research 158, no. 3 (2019): 115–20. http://dx.doi.org/10.1159/000501378.

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Unbalanced translocations of Y-chromosomal fragments harboring the sex-determining region Y gene (SRY) to the X chromosome or an autosome result in 46,XX and 45,X testicular disorders of sex development (DSD), respectively. Of these, Y;autosome translocation is an extremely rare condition. Here, we identified a 20-year-old man with a 45,X,t(Y;7)(q11.21;q35) karyotype, who exhibited unilateral cryptorchidism, small testis, intellectual disability, and various congenital anomalies. The fusion junction of the translocation was blunt, and the breakpoint-flanking regions shared only 50% similarity.

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Feldman, Andrew L., Ahmet Dogan, David I. Smith, Mark E. Law, Stephen M. Ansell, Sarah H. Johnson, Julie C. Porcher, et al. "Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing." Blood 117, no. 3 (January 20, 2011): 915–19. http://dx.doi.org/10.1182/blood-2010-08-303305.

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Abstract The genetics of peripheral T-cell lymphomas are poorly understood. The most well-characterized abnormalities are translocations involving ALK, occurring in approximately half of anaplastic large cell lymphomas (ALCLs). To gain insight into the genetics of ALCLs lacking ALK translocations, we combined mate-pair DNA library construction, massively parallel (“Next Generation”) sequencing, and a novel bioinformatic algorithm. We identified a balanced translocation disrupting the DUSP22 phosphatase gene on 6p25.3 and adjoining the FRA7H fragile site on 7q32.3 in a systemic ALK-negative ALC

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Crasta, O. R., M. G. Francki, D. B. Bucholtz, H. C. Sharma, J. Zhang, R. C. Wang, H. W. Ohm, and J. M. Anderson. "Identification and characterization of wheat-wheatgrass translocation lines and localization of barley yellow dwarf virus resistance." Genome 43, no. 4 (August 1, 2000): 698–706. http://dx.doi.org/10.1139/g00-023.

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Stable introgression of agronomically important traits into crop plants through wide crossing often requires the generation and identification of translocation lines. However, the low efficiency of identifying lines containing translocations is a significant limitation in utilizing valuable alien chromatin-derived traits. Selection of putative wheatgrass-wheat translocation lines based on segregation ratios of progeny from γ-irradiated seed using a standard phenotypic analysis resulted in a low 4% success rate of identifying barley yellow dwarf virus (BYDV) resistant and susceptible translocat

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Irvine, Robin. "Inositol phospholipids: Translocation, translocation, translocation …" Current Biology 8, no. 16 (July 1998): R557—R559. http://dx.doi.org/10.1016/s0960-9822(07)00360-0.

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32

King, I. P., K. A. Purdie, C. J. Liu, S. M. Reader, T. S. Pittaway, S. E. Orford, and T. E. Miller. "Detection of interchromosomal translocations within the Triticeae by RFLP analysis." Genome 37, no. 5 (October 1, 1994): 882–87. http://dx.doi.org/10.1139/g94-125.

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Twenty-three wheat/alien addition or substitution lines were screened using restriction fragment length polymorphisms for the presence or absence of 4/5 and 4/7 reciprocal translocations in the alien chromosomes. Such translocations have previously been identified in wheat and rye. Group 4 and group 5 Aegilops umbellulata, Triticum urartu, and Thinopyrum bessarabicum chromosomes were found to carry 4/5 translocations. Evidence for a 4/7 translocation was also found in Secale montanum. The presence of the 4/5 translocations in T. urartu indicates that the translocation predates the polyploidiza

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Soster, Erica, Brittany Dyr, Samantha Caldwell, Amanda Sussman, and Hany Magharyous. "Prenatal cfDNA Screening for Emanuel Syndrome and Other Unbalanced Products of Conception in Carriers of the Recurrent Balanced Translocation t(11;22): One Laboratory’s Retrospective Experience." Genes 14, no. 10 (October 10, 2023): 1924. http://dx.doi.org/10.3390/genes14101924.

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Prenatal cell-free DNA screening (cfDNA) can identify fetal chromosome abnormalities beyond common trisomies. Emanuel syndrome (ES), caused by an unbalanced translocation between chromosomes 11 and 22, has lacked a reliable prenatal screening option for families with a carrier parent. A cohort of cases (n = 46) sent for cfDNA screening with indications and/or results related to ES was queried; diagnostic testing and pregnancy outcomes were requested and analyzed. No discordant results were reported or suspected; there were ten true positives with diagnostic confirmation, six likely concordant

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Nagy, E. D., M. Molnár-Láng, G. Linc, and L. Láng. "Identification of wheat-barley translocations by sequential GISH and two-colour FISH in combination with the use of genetically mapped barley SSR markers." Genome 45, no. 6 (December 1, 2002): 1238–47. http://dx.doi.org/10.1139/g02-068.

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Five wheatbarley translocations in a wheat background were characterized through the combination of cytogenetic and molecular genetic approaches. The wheat chromosome segments involved in the translocations were identified using sequential GISH and two-colour FISH with the probes pSc119.2 and pAs1. The barley chromatin in these lines was identified using SSR markers. A total of 45 markers distributed over the total barley genome were selected from a recently published linkage map of barley and tested on the translocation lines. The following translocations were identified: 2DS.2DL1HS, 3HS.3B

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Li, Hong-Jie, Bei-Hai Guo, Yi-Wen Li, Li-Qun Du, Xu Jia, and Chih-Ching Chu. "Molecular cytogenetic analysis of intergeneric chromosomal translocations between wheat (Triticum aestivum L.) and Dasypyrum villosum arising from tissue culture." Genome 43, no. 5 (October 1, 2000): 756–62. http://dx.doi.org/10.1139/g00-020.

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Fluorescence in situ hybridization (FISH) was applied with total genomic DNA extracted from Dasypyrum villosum (L.) Candargy as a probe to characterize chromosome translocations arising from tissue culture in hybrids of Triticum aestivum × (T. durum - D. villosum, amphiploid). Chromosome translocations between wheat and D. villosum occurred in callus cells at an average frequency of 1.9%. Translocations existed not only in callus cells but also in regenerants. Three plants with translocation chromosomes were characterized among 66 regenerants of T. aestivum 'Chinese Spring' × 'TH1W' and 'NPFP'

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Ostevik, Kate L., Kieran Samuk, and Loren H. Rieseberg. "Ancestral Reconstruction of Karyotypes Reveals an Exceptional Rate of Nonrandom Chromosomal Evolution in Sunflower." Genetics 214, no. 4 (February 7, 2020): 1031–45. http://dx.doi.org/10.1534/genetics.120.303026.

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Mapping the chromosomal rearrangements between species can inform our understanding of genome evolution, reproductive isolation, and speciation. Here, we present a novel algorithm for identifying regions of synteny in pairs of genetic maps, which is implemented in the accompanying R package syntR. The syntR algorithm performs as well as previous ad hoc methods while being systematic, repeatable, and applicable to mapping chromosomal rearrangements in any group of species. In addition, we present a systematic survey of chromosomal rearrangements in the annual sunflowers, which is a group known

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Denzel, Sabine, Tamara Alpermann, Wolfgang Kern, Susanne Schnittger, Torsten Haferlach, and Claudia Haferlach. "MYC Translocations In Mature B-Cell Neoplasms: Single, Double, Triple and Quadruple Hit Lymphoma." Blood 122, no. 21 (November 15, 2013): 2997. http://dx.doi.org/10.1182/blood.v122.21.2997.2997.

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Abstract Background According to the WHO classification from 2008 the subclassification of mature B-cell neoplasms is based mainly on cytomorphological features. So far entities are not defined by genetics, although some close associations between morphology and genetic abnormalities exist like MYC translocation and Burkitt lymphoma/leukemia, CCND1-translocation and mantle cell lymphoma, BCL6 translocation and diffuse large B-cell lymphoma and BCL2 translocation and follicular lymphoma. However, most of the mentioned genetic abnormalities are characteristic but not specific for the respective

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Auger, Donald L., and William F. Sheridan. "Negative Crossover Interference in Maize Translocation Heterozygotes." Genetics 159, no. 4 (December 1, 2001): 1717–26. http://dx.doi.org/10.1093/genetics/159.4.1717.

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Abstract Negative interference describes a situation where two genetic regions have more double crossovers than would be expected considering the crossover rate of each region. We detected negative crossover interference while attempting to genetically map translocation breakpoints in maize. In an attempt to find precedent examples we determined there was negative interference among previously published translocation breakpoint mapping data in maize. It appears that negative interference was greater when the combined map length of the adjacent regions was smaller. Even positive interference ap

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Li, Wanlong, Ghana S. Challa, Huilan Zhu, and Wenjie Wei. "Recurrence of Chromosome Rearrangements and Reuse of DNA Breakpoints in the Evolution of the Triticeae Genomes." G3 Genes|Genomes|Genetics 6, no. 12 (December 1, 2016): 3837–47. http://dx.doi.org/10.1534/g3.116.035089.

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Abstract Chromosomal rearrangements (CRs) play important roles in karyotype diversity and speciation. While many CR breakpoints have been characterized at the sequence level in yeast, insects, and primates, little is known about the structure of evolutionary CR breakpoints in plant genomes, which are much more dynamic in genome size and sequence organization. Here, we report identification of breakpoints of a translocation between chromosome arms 4L and 5L of Triticeae, which is fixed in several species, including diploid wheat and rye, by comparative mapping and analysis of the draft genome a

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Kodama, M., M. S. Rose, G. Yang, S. H. Yun, O. C. Yoder, and B. G. Turgeon. "The Translocation-Associated Tox1 Locus of Cochliobolus heterostrophus Is Two Genetic Elements on Two Different Chromosomes." Genetics 151, no. 2 (February 1, 1999): 585–96. http://dx.doi.org/10.1093/genetics/151.2.585.

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Abstract Previously, Tox1 was defined as a single genetic element controlling the difference between races of Cochliobolus heterostrophus: race T is highly virulent on T-cytoplasm corn and produces the polyketide T-toxin; race O is weakly virulent and does not produce T-toxin. Here we report that Tox1 is two loci, Tox1A and Tox1B, on two different chromosomes. Evidence for two loci derives from: (1) the appearance of 25% Tox+ progeny in crosses between induced Tox1– mutants, one defective at Tox1A, the other at Tox1B; (2) the ability of Tox1A– + Tox1B– heterokaryons to complement for T-toxin p

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Coci, Emanuele G., Andrea Auhuber, Anna Langenbach, Kristin Mrasek, Joachim Riedel, Andreas Leenen, Thomas Lücke, and Thomas Liehr. "Novel Unbalanced Translocations Affecting the Long Arms of Chromosomes 10 and 22 Cause Complex Syndromes with Very Severe Neurodevelopmental Delay, Speech Impairment, Autistic Behavior, and Epilepsy." Cytogenetic and Genome Research 151, no. 4 (2017): 171–78. http://dx.doi.org/10.1159/000471501.

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Isolated abnormalities in terminal regions of chromosomes 10q and 22q were formerly described in patients affected by neuropsychological impairment, abnormal facies, and heterogeneous structural abnormalities of the body. Chromosomes 10q and 22q harbor important genes that play a major role in CNS development, like DOCK1 and SHANK3, and in overall body growth, like FGFR2 and HTRA1. By using clinical, neuroradiological, neurophysiological, and genetic assessment, we studied 3 siblings affected by 2 different forms of very severe neuropsychological impairment with structural physical abnormaliti

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Figueiras, Ana M., Maria T. Gonzalez-Jaen, Julio Salinas, and Cesar Benito. "ASSOCIATION OF ISOZYMES WITH A RECIPROCAL TRANSLOCATION IN CULTIVATED RYE (SECALE CEREALE L.)." Genetics 109, no. 1 (January 1, 1985): 177–93. http://dx.doi.org/10.1093/genetics/109.1.177.

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ABSTRACT In rye (Secale cereale L. cv. "Ailés") the progeny of a cross between a structural heterozygote for a reciprocal translocation (involving the 1R chromosome) and a homozygote for the standard chromosome arrangement were analyzed for the electrophoretic patterns of eight different leaf isozymes and also for their meiotic configuration at metaphase I.—The Got-3 and Mdh-2b loci are linked to each other and also to the reciprocal translocation. The Mdh-2b locus is located in the interstitial segment of the 3Rq chromosome arm, with an estimated distance of 8 cM to the breakpoint. Therefore,

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43

Talbert, P. B., C. D. LeCiel, and S. Henikoff. "Modification of the Drosophila heterochromatic mutation brownDominant by linkage alterations." Genetics 136, no. 2 (February 1, 1994): 559–71. http://dx.doi.org/10.1093/genetics/136.2.559.

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Abstract The variegating mutation brownDominant (bwD) of Drosophila melanogaster is associated with an insertion of heterochromatin into chromosome arm 2R at 59E, the site of the bw gene. Mutagenesis produced 150 dominant suppressors of bwD variegation. These fall into two classes: unlinked suppressors, which also suppress other variegating mutations; and linked chromosome rearrangements, which suppress only bwD. Some rearrangements are broken at 59E, and so might directly interfere with variegation caused by the heterochromatic insertion at that site. However, most rearrangements are transloc

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Menzel, Margaret Y., and Brian J. Dougherty. "Transmission of Duplication-Deficiencies from Cotton Translocations Is Unrelated to Map Lengths of the Unbalanced Segments." Genetics 116, no. 2 (June 1, 1987): 321–30. http://dx.doi.org/10.1093/genetics/116.2.321.

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ABSTRACT Adjacent-1 duplication-deficiencies (dp-dfs) are readily recovered from most heterozygous translocations in Gossypium hirsutum L., but frequencies of specific cytotypes differ widely in progenies from heterozygote (♀) x standard crosses. Surprisingly, these frequencies seem to be unrelated to the primary (postmeiotic) frequencies predicted by metaphase I configurations or to the proportion of the chromosome arm that is duplicate or deficient. Deficiencies and duplications from different translocations involving the same arm, as well as the two complementary dp-dfs from the same transl

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Voelker, Rodger, Janet Mendel-Hartvig, and Alice Barkan. "Transposon-Disruption of a Maize Nuclear Gene, tha1, Encoding a Chloroplast SecA Homologue: In Vivo Role of cp-SecA in Thylakoid Protein Targeting." Genetics 145, no. 2 (February 1, 1997): 467–78. http://dx.doi.org/10.1093/genetics/145.2.467.

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A nuclear mutant of maize, tha1, which exhibited defects in the translocation of proteins across the thylakoid membrane, was described previously. A transposon insertion at the tha1 locus facilitated the cloning of portions of the tha1 gene. Strong sequence similarity with secA genes from bacteria, pea and spinach indicates that tha1 encodes a SecA homologue (cp-SecA). The tha1-ref allele is either null or nearly so, in that tha1 mRNA is undetectable in mutant leaves and cp-SecA accumulation is reduced ≥40-fold. These results, in conjunction with the mutant phenotype described previously, demo

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46

Cruz-Coke, Ricardo. "Complex familial translocation." Clinical Genetics 37, no. 2 (June 28, 2008): 158–59. http://dx.doi.org/10.1111/j.1399-0004.1990.tb03494.x.

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Lu, Benjamin C. "Karyotyping ofNeurospora crassausing synaptonemal complex spreads of translocation quadrivalents." Genome 49, no. 6 (June 1, 2006): 612–18. http://dx.doi.org/10.1139/g06-008.

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The purposes of the present research are (i) to establish the karyotype of Neursopora crassa using visualization of kinetochores in the synaptonemal complex (SC) spreads, (ii) to assign each chromosome to a linkage group, and (iii) to examine chromosome pairing and recombination nodules in quadrivalents. Two strains containing reciprocal translocations were used: T(I;II)4637, which involves linkage groups I and II, and alcoy, which contains 3 independent translocations involving I and II, IV and V, and III and VI. Visualization of kinetochores in the spreads requires the use of freshly prepare

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48

Perkins, David D., Robert L. Metzenberg, Namboori B. Raju, Eric U. Selker, and Edward G. Barry. "REVERSAL OF A NEUROSPORA TRANSLOCATION BY CROSSING OVER INVOLVING DISPLACED rDNA, AND METHYLATION OF THE rDNA SEGMENTS THAT RESULT FROM RECOMBINATION." Genetics 114, no. 3 (November 1, 1986): 791–817. http://dx.doi.org/10.1093/genetics/114.3.791.

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ABSTRACT In translocation OY321 of Neurospora crassa, the nucleolus organizer is divided into two segments, a proximal portion located interstitially in one interchange chromosome, and a distal portion now located terminally on another chromosome, linkage group I. In crosses of Translocation x Translocation, exceptional progeny are recovered nonselectively in which the chromosome sequence has apparently reverted to Normal. Genetic, cytological, and molecular evidence indicates that reversion is the result of meiotic crossing over between homologous displaced rDNA repeats. Marker linkages are w

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Robinson, David O., Yvonne Boyd, David Cockburn, Morag N. Collinson, Ian Craig, and Patricia A. Jacobs. "The parental origin of de novo X-autosome translocations in females with Duchenne muscular dystrophy revealed by M27ß methylation analysis." Genetics Research 56, no. 2-3 (October 1990): 135–40. http://dx.doi.org/10.1017/s0016672300035217.

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SummaryThe parental origin of 3 de novo X-autosome translocations in females with Duchenne Muscular Dystrophy (DMD) was studied by means of methylation analysis using the X-linked probe M27ß. In all three the translocation was found to be paternal in origin. The parental origin of X-autosome translocations in females with and without DMD is compared with other structural abnormalities of the X and with autosomal translocations.

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Lee, J. H., S. M. Kaeppler, R. A. Graybosch, and R. G. Sears. "A PCR assay for detection of a 2RL.2BS wheat–rye chromosome translocation." Genome 39, no. 3 (June 1, 1996): 605–8. http://dx.doi.org/10.1139/g96-076.

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A 2RL.2BS wheat–rye translocation, present in the wheat germplasm line Hamlet, carries a gene for resistance to Hessian fly biotype L, one of the most virulent biotypes presently encountered in wheat production environments. Unlike several other wheat–rye chromosome translocations common in wheat breeding programs, 2RL lacks genes encoding storage proteins or other easily selected markers. Oligonucleotide primers synthesized from published sequences derived from the R173 family of moderately repetitive rye DNA were used in the DNA polymerase chain reaction (PCR) to identify specific markers fo

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