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Relevant bibliographies by topics / Transmembrane mucins

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Academic literature on the topic 'Transmembrane mucins'

Author: Grafiati

Published: 21 December 2024

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Journal articles on the topic "Transmembrane mucins"

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van Putten, Jos P. M., and Karin Strijbis. "Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer." Journal of Innate Immunity 9, no. 3 (2017): 281–99. http://dx.doi.org/10.1159/000453594.

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Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound mucins that have both barrier and signaling functions. The family of transmembrane mucins consists of diverse members that share a few characteristics. The highly glycosylated extracellular mucin domains inhibit invasion by pathogenic bacteria and can form a tight mesh structure

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Sun, Lingbo, Yuhan Zhang, Wenyan Li, Jing Zhang, and Yuecheng Zhang. "Mucin Glycans: A Target for Cancer Therapy." Molecules 28, no. 20 (2023): 7033. http://dx.doi.org/10.3390/molecules28207033.

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Mucin glycans are an important component of the mucus barrier and a vital defence against physical and chemical damage as well as pathogens. There are 20 mucins in the human body, which can be classified into secreted mucins and transmembrane mucins according to their distributions. The major difference between them is that secreted mucins do not have transmembrane structural domains, and the expression of each mucin is organ and cell-specific. Under physiological conditions, mucin glycans are involved in the composition of the mucus barrier and thus protect the body from infection and injury.

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Ballester, Milara, and Cortijo. "Mucins as a New Frontier in Pulmonary Fibrosis." Journal of Clinical Medicine 8, no. 9 (2019): 1447. http://dx.doi.org/10.3390/jcm8091447.

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Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary disease with a median survival of 3–5 years after diagnosis. Recent evidence identifies mucins as key effectors in cell growth and tissue remodeling processes compatible with the processes observed in IPF. Mucins are classified in two groups depending on whether they are secreted (secreted mucins) or tethered to cell membranes (transmembrane mucins). Secreted mucins (MUC2, MUC5AC, MUC5B, MUC6-8 and MUC19) are released to the extracellular medium and recent evidence has shown that a promoter polymorphism in

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Chatterjee, Maitrayee, Liane Z. X. Huang, Anna Z. Mykytyn, et al. "Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface." PLOS Pathogens 19, no. 8 (2023): e1011571. http://dx.doi.org/10.1371/journal.ppat.1011571.

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Mucins play an essential role in protecting the respiratory tract against microbial infections while also acting as binding sites for bacterial and viral adhesins. The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by mucociliary clearance. Transmembrane mucins MUC1, MUC4, and MUC16 can restrict microbial invasion at the apical surface of the epithelium. In this study, we determined the impact of host mucins and mucin glycans on epithelial entry of SARS-CoV-2. Human lung epithelial Calu-3 cells express the SARS-CoV-2 entry receptor ACE2 and high levels of glycos

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Hauber, Hans-Peter, Susan C. Foley, and Qutayba Hamid. "Mucin Overproduction in Chronic Inflammatory Lung Disease." Canadian Respiratory Journal 13, no. 6 (2006): 327–35. http://dx.doi.org/10.1155/2006/901417.

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Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.

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Constantinou, Pamela E., Brian P. Danysh, Neeraja Dharmaraj, and Daniel D. Carson. "Transmembrane mucins as novel therapeutic targets." Expert Review of Endocrinology & Metabolism 6, no. 6 (2011): 835–48. http://dx.doi.org/10.1586/eem.11.70.

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Hansson, Gunnar C. "Mucins and the Microbiome." Annual Review of Biochemistry 89, no. 1 (2020): 769–93. http://dx.doi.org/10.1146/annurev-biochem-011520-105053.

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Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two types, gel-forming and transmembrane, all characterized by large, highly O-glycosylated mucin domains that are diversely decorated by Golgi glycosyltransferases to become extended rodlike structures. The general functions of mucins on internal epithelial surfaces are to wash away microorganisms and, even more importantly, to build protective barriers. The latter function is most evident in the large intestine, where the inner mucus layer separ

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Mall, A. S. "Analysis of mucins: role in laboratory diagnosis." Journal of Clinical Pathology 61, no. 9 (2008): 1018–24. http://dx.doi.org/10.1136/jcp.2008.058057.

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Mucins are high molecular weight glycoproteins with complex oligosaccharide side chains attached to the apomucin protein backbone by O-glycosidic linkage; they are found in crude mucus gels that protect epithelial surfaces in the major tracts of the body and as transmembrane proteins expressed on the apical cell surface of glandular and ductal epithelia of various organs. Changes in the sequence of glycosylation of mucins in different settings generate a variety of epitopes in the oligosaccharide side chains of mucins, including newly expressed blood-group antigens, distinguishing between norm

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Itah, Shir, David Elad, Ariel J. Jaffa, Dan Grisaru, and Mordechai Rosner. "Transmembrane Mucin Response in Conjunctival Epithelial Cells Exposed to Wall Shear Stresses." International Journal of Molecular Sciences 24, no. 7 (2023): 6589. http://dx.doi.org/10.3390/ijms24076589.

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Human conjunctival epithelium cells (HCEC) line the inner surface of the eyelid and cover the sclera and are continuously subjected to wall shear stresses (WSS). The effects of external forces on the conjunctival epithelium are not fully known. The conjunctival epithelium contains stratified squamous cells that synthesize the membrane-spanning mucins MUC1 and MUC16, which play important roles in protecting the ocular surface. Alterations in both gel-forming and membrane-tethered mucins occur in drying ocular surface diseases. The aim of this study was to explore the mechanobiological character

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Kramer, Jessica R., Bibiana Onoa, Carlos Bustamante, and Carolyn R. Bertozzi. "Chemically tunable mucin chimeras assembled on living cells." Proceedings of the National Academy of Sciences 112, no. 41 (2015): 12574–79. http://dx.doi.org/10.1073/pnas.1516127112.

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Mucins are a family of secreted and transmembrane glycoproteins characterized by a massive domain of dense O-glycosylation on serine and threonine residues. Mucins are intimately involved in immunity and cancer, yet elucidation of the biological roles of their glycodomains has been complicated by their massive size, domain polymorphisms, and variable glycosylation patterns. Here we developed a synthetic route to a library of compositionally defined, high-molecular weight, dual end-functionalized mucin glycodomain constructs via N-carboxyanhydride polymerization. These glycopolypeptides are the

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Dissertations / Theses on the topic "Transmembrane mucins"

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Lang, Tiange. "Evolution of transmembrane and gel-forming mucins studied with bioinformatic methods /." Göteborg : The Sahlgrenska Academy at Göteborg University, Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, 2007. http://hdl.handle.net/2077/7502.

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Ammam, Ianis. "Études et caractérisations tribologiques des mécanismes biophysiques de la lubrification orale." Electronic Thesis or Diss., Ecully, Ecole centrale de Lyon, 2024. http://www.theses.fr/2024ECDL0042.

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L’étude de la lubrification orale devient une problématique actuelle pour l’industrie agroalimentaire. Les analyses quantitatives permettent de comprendre et d’anticiper des mécanismes physiologiques, tels que la prédiction des phénomènes d’astringence des produits alimentaires. L’astringence se manifeste par une diminution de la lubrification de la muqueuse orale après la consommation de produits d’origine végétale. Cependant, les recherches actuelles sur la lubrification orale s’appuient sur des matériaux synthétiques qui représentent mal les tissus buccaux. Elles négligent les interactions

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Chan, Becky Ka Man. "Expression of beta subunit of epithelium sodium channel and cystic fibrosis transmembrane regulator in small airways obstruction in chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/4072.

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Background: Excess plugging of small airways is associated with premature death in chronic obstructive pulmonary disease (COPD). Over-expression of beta-epithelial sodium channel (β-ENaC) in airway epithelia in mice resulted in plugging of small airways while cystic fibrosis transmembrane regulator (CFTR) negatively regulated ENaC activity in cell models. Purpose: To test the hypothesis that accumulation of mucus exudates observed with the progression of COPD is related to excess airway epithelial sodium re-absorption as a result of over-expression of β-ENaC and reduced expression of CFTR by s

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Tushar, Piyush. "The role of transmembrane mucin protein MUC1 in anoikis and in EGFR activation of human epithelial cancer cells." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3018915/.

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MUC1 is a large, heavily glycosylated transmembrane mucin protein expressed on the apical membrane of normal epithelial cells. In epithelial cancer cells, however, MUC1 is overexpressed, abnormally glycosylated and loses its apical polarization, becoming expressed over the entire cell surface. Galectin-3, a β-galactoside-binding protein expressed by many types of human cells, is a natural ligand for MUC1. Recent studies by ourselves and others have revealed that the interaction between galectin-3 and MUC1 induces MUC1 cell surface polarization and the exposure of underlying smaller cell surfac

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Syrjänen, R. (Riikka). "TIM family molecules in hematopoiesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204246.

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Abstract Hematopoietic cells, i.e., erythrocytes, platelets and white blood cells, differentiate from hematopoietic stem cells in a process that is similar in vertebrates. Hematopoiesis is regulated by molecules expressed by both the hematopoietic stem and progenitor cells and the surrounding microenvironments. Knowledge of these molecules is important since many of the genes involved in normal hematopoiesis are mutated in leukemia. Furthermore, this information can be utilized in more efficient isolation and expansion of hematopoietic cells in vitro. However, these molecules are not yet suffi

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Books on the topic "Transmembrane mucins"

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Pérez Reytor,, Diliana Celeste. Identificación de nuevos marcadores de virulencia en cepas no toxigénicas de vibrio parahaemolyticus. Universidad Autónoma de Chile, 2019. http://dx.doi.org/10.32457/20.500.12728/87462019dcbm7.

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Vibrio parahaemolyticus es la principal causa de gastroenteritis transmitida por mariscos en todo el mundo. La virulencia de V. parahaemolyticus se ha atribuido hasta ahora principalmente a la hemolisina directa termoestable (TDH) y la hemolisina relacionada con TDH (TRH). Recientemente el Sistema de Secreción de tipo III del cromosoma II (T3SS2), el cual codifica para varios efectores, ha sido relacionado con citotoxicidad y enterotoxicidad. Después de la aparición y posterior caída de la cepa pandémica, se han notificado casos de diarrea producidos por cepas clínicas que carecen de los genes

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Book chapters on the topic "Transmembrane mucins"

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Constantinou, Pamela E., Micaela Morgado, and Daniel D. Carson. "Transmembrane Mucin Expression and Function in Embryo Implantation and Placentation." In Regulation of Implantation and Establishment of Pregnancy in Mammals. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15856-3_4.

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Aydin Acar, Cigdem. "Cystic Fibrosis: Clinical Characteristics, Molecular Mechanisms and Treatment." In Molecular Approaches in Medicine. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359524.7.

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Cystic Fibrosis (CF) is a genetic disorder that primarily affects the respiratory and digestive systems. This chapter provides a comprehensive overview of CF, including its pathophysiology, clinical manifestations, diagnosis and treatment. CF is caused by mutations in the CFTR gene, which encodes the cystic fibrosis transmembrane conductance regulator protein. This protein is crucial for the regulation of chloride and sodium ions across epithelial membranes. Mutations lead to the production of thick, sticky mucus that clogs the airways and various channels throughout the body. This chapter describes the main symptoms of CF, including chronic cough, progressive lung damage due to recurrent lung infections, and gastrointestinal problems such as pancreatic enzyme deficiency, malabsorption, and meconium ileus in newborns. CF can also affect the liver, sweat glands, and reproductive system. Diagnostic criteria for CF are discussed and the importance of newborn screening, sweat chloride testing, and genetic testing is emphasized. This chapter also reviews current treatment options aimed at managing symptoms and improving quality of life. The role of CFTR modulators, a new class of drugs targeting the underlying genetic disorder, is also highlighted and concludes with a discussion of new therapies and ongoing research aimed at finding a cure for CF.

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"Transmembrane Mucin 1." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103949.

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Robinson, Chapman. "Cystic fibrosis (CF)." In Oxford Handbook of Respiratory Medicine, edited by Stephen J. Chapman, Grace V. Robinson, Rahul Shrimanker, Chris D. Turnbull, and John M. Wrightson. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198837114.003.0024.

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Cystic fibrosis (CF) is a multi-system disease due to mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a complex chloride channel. CFTR is essential for regulating chloride permeability across epithelial tissues and, in addition, has other complex cellular roles. Loss of CFTR function or quantity causes inadequate hydration of mucous secretions. In the lungs this results in defective mucociliary clearance, mucus obstruction of the luminal space, and colonization with pathogenic bacteria. Recurrent cycles of infection and inflammation contribute to lung damage and subsequent development of bronchiectasis. In the pancreas, the exocrine ducts become blocked by secretions, leading to pancreatic destruction, pancreatic enzyme insufficiency, and CF-related diabetes.

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Conference papers on the topic "Transmembrane mucins"

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Maher, Diane M., Phillip Stephenson, Brij K. Gupta, et al. "Abstract 3589: Comparative expression profile of transmembrane mucin MUC1 in breast cancer from American Indian and Caucasian women." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3589.

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Abraham, William, Juan Sabater, and Tahir Ahmed. "Allosteric inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) slows airway mucus transport in normal sheep." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2054.

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