Log in

Relevant bibliographies by topics / Transmissio Blocking Therapy / Journal articles

To see the other types of publications on this topic, follow the link: Transmissio Blocking Therapy.

Journal articles on the topic 'Transmissio Blocking Therapy'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Transmissio Blocking Therapy.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Sun, Xiaojun, Chengwei Wang, Bian Wang, et al. "Efficacy of Nucleotide/Nucleoside Analogues and Hepatitis B Immunoglobulin Therapy in Blocking Mother-to-Child Transmission of Hepatitis B in an Eastern Chinese Group." Infectious Diseases in Obstetrics and Gynecology 2020 (December 17, 2020): 1–4. http://dx.doi.org/10.1155/2020/4305950.

Full text

Abstract:

The objective of this study was to investigate the efficacy and potential side-effects of nucleotide/nucleoside analogues and hepatitis B immunoglobulin injection of newborns in blocking mother-to-child transmission of hepatitis B virus in the middle and late pregnancy period. 238 cases of enrolled pregnant women were divided into the Telbivudine group, the Tenofovir group, the Lamivudine group, and the hepatitis B immunoglobulin (HBIG) group. Enrolled patients received corresponding therapies. Clinical and laboratory data were collected. Results showed that the levels of HBV DNA of the enroll

APA, Harvard, Vancouver, ISO, and other styles

2

Xiao, Fan, Ling Wu, Xiaoxia Zhu, et al. "Interleukin-6 blocking therapy for COVID-19: From immune pathogenesis to clinical outcomes." Rheumatology and Immunology Research 3, no. 1 (2022): 11–16. http://dx.doi.org/10.2478/rir-2022-0002.

Full text

Abstract:

Abstract As a newly emerged infectious disease, the coronavirus disease 2019 (COVID-19) has caused millions of deaths, resulting in a global health challenge. Currently, several vaccines have been approved with significant benefits against disease transmission. However, effective therapies are still needed for the clinical management of infected COVID-19 patients. Available evidence has indicated elevated levels of proinflammatory cytokines, including interleukin-6 (IL-6), in COVID-19 patients, with cytokine storm involving excessive cytokine release being observed in some severe cases. Severa

APA, Harvard, Vancouver, ISO, and other styles

3

TCHINDA, P. MOUOFO, JEAN JULES TEWA, BOULECHARD MEWOLI, and SAMUEL BOWONG. "A THEORETICAL ASSESSMENT OF THE EFFECTS OF DISTRIBUTED DELAY ON THE TRANSMISSION DYNAMICS OF HEPATITIS B." Journal of Biological Systems 23, no. 03 (2015): 423–55. http://dx.doi.org/10.1142/s0218339015500229.

Full text

Abstract:

In this paper, we investigate the global dynamics of a system of delay differential equations which describes the interaction of hepatitis B virus (HBV) with both liver and blood cells. The model has two distributed time delays describing the time needed for infection of cell and virus replication. We also include the efficiency of drug therapy in inhibiting viral production and the efficiency of drug therapy in blocking new infection. We compute the basic reproduction number and find that increasing delays will decrease the value of the basic reproduction number. We study the sensitivity anal

APA, Harvard, Vancouver, ISO, and other styles

4

Li, Sirui. "Development of Vyvgart (Efgartigimod Alfa-Fcab) for Generalized Myasthenia Gravis (gMG) Therapy." Theoretical and Natural Science 3, no. 1 (2023): 487–98. http://dx.doi.org/10.54254/2753-8818/3/20220330.

Full text

Abstract:

Generalized myasthenia gravis (gMG) is a type of myasthenia gravis (MG), a relatively rare neurological disease which would lead to muscle weakness and be life threatening. The pathogenesis of MG is associated with antibodies against acetylcholine receptors, which blocks the neuromuscular transmission. Vyvgart (efgartigimod alfa-fcab) is a recently approved drug for gMG therapy that targets the neonatal Fc receptor (FcRn). By inhibiting the interaction between FcRn and Immunoglobulin G (IgG), efgartigimod promotes the degradation of IgG and autoantibodies, therefore alleviates the symptoms of

APA, Harvard, Vancouver, ISO, and other styles

5

Liu, Zhihua, Huijie Guo, Yunfei Gao, Xueru Yin, and Jing Hu. "Impact of antiviral therapy for blocking mother-to-child transmission on virus quasispecies in pregnant women with chronic HBV infection." Journal of Hepatology 73 (August 2020): S851. http://dx.doi.org/10.1016/s0168-8278(20)32146-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Koivisto, Ari, Niina Jalava, Raymond Bratty, and Antti Pertovaara. "TRPA1 Antagonists for Pain Relief." Pharmaceuticals 11, no. 4 (2018): 117. http://dx.doi.org/10.3390/ph11040117.

Full text

Abstract:

Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation of nociceptive primary sensory neurons, astroglia, oligodendrocytes and Schwann cells. In peripheral terminals of nociceptive primary sensory neurons, it is involved in the transduction of potentially harmful stimuli and in their central terminals it is involved in amplification of nociceptive transmission. TRPA1 is a final common pathway for a larg

APA, Harvard, Vancouver, ISO, and other styles

7

Luvisetto, Siro. "Botulinum Neurotoxins beyond Neurons: Interplay with Glial Cells." Toxins 14, no. 10 (2022): 704. http://dx.doi.org/10.3390/toxins14100704.

Full text

Abstract:

In recent years, numerous studies have highlighted the significant use of botulinum neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The therapeutic action is exerted with the selective cleavage of specific sites of the SNARE’s protein complex, which plays a key role in the vesicular neuroexocytosis which is responsible for neural transmission. The primary target of the BoNTs’ action is the peripheral neuromuscular junction (NMJ), where, by blocking cholinergic neurons releasing acetylcholine (ACh), they interfere with neural transmission. A great deal of expe

APA, Harvard, Vancouver, ISO, and other styles

8

Xu, Jinhu, and Guokun Huang. "Threshold Dynamics for a Time-Periodic Viral Infection Model with Cell-to-Cell Transmission and Drug Treatments." Mathematical Problems in Engineering 2022 (March 21, 2022): 1–14. http://dx.doi.org/10.1155/2022/2289138.

Full text

Abstract:

In this study, a time-periodic viral infection model incorporating cell-to-cell infection and antiretroviral therapy has been investigated. The basic reproduction number ℛ 0 has been defined as a threshold parameter which governs whether or not the disease dies out. Theoretical results indicate that the disease goes to extinction if ℛ 0 < 1 and otherwise the disease will uniformly persist. The global stabilities of the equilibria for the corresponding autonomous model have been investigated by constructing suitable Lyapunov functions. Moreover, numerical simulations have been carried out to

APA, Harvard, Vancouver, ISO, and other styles

9

KRAMER, S. C., and S. BANSAL. "Assessing the use of antiviral treatment to control influenza." Epidemiology and Infection 143, no. 8 (2014): 1621–31. http://dx.doi.org/10.1017/s0950268814002520.

Full text

Abstract:

SUMMARYVaccines are the cornerstone of influenza control policy, but can suffer from several drawbacks. Seasonal influenza vaccines are prone to production problems and low efficacies, while pandemic vaccines are unlikely to be available in time to slow a rapidly spreading global outbreak. Antiviral therapy was found to be beneficial during the influenza A(H1N1)pdm09 pandemic even with limited use; however, antiviral use has decreased further since then. We sought to determine the role antiviral therapy can play in pandemic and seasonal influenza control using conservative estimates of antivir

APA, Harvard, Vancouver, ISO, and other styles

10

Moroz, Volodymyr, Volodymyr Hromov, and Oleksandr Lohvinenko. "SPECIAL FEATURES OF OPTIMIZATION DESIGN AND EVALUATION OF TECHNICAL RESOURCE FOR TRACTION GEAR TRANSMISSIONS OF RAILWAY ROLLING STOCK." Collection of Scientific Works of the Ukrainian State University of Railway Transport, no. 205 (September 29, 2023): 86–97. http://dx.doi.org/10.18664/1994-7852.205.2023.288831.

Full text

Abstract:

The article highlights the peculiarities of optimization design for traction gear transmissions of railway rolling stock, aimed at determining the main structural parameters of corresponding paired gears and toothed wheels to increase their technical resource. The recommendations provide a formalized description of such investigations in the form of multidimensional optimization problems with constraints. Significant attention is given to the selection peculiarities of main variable parameters, primary criteria (related to reducing wear on tooth contact surfaces), and secondary numerical crite

APA, Harvard, Vancouver, ISO, and other styles

11

Czuppon, Peter, Florence Débarre, Antonio Gonçalves, et al. "Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action." PLOS Computational Biology 17, no. 3 (2021): e1008752. http://dx.doi.org/10.1371/journal.pcbi.1008752.

Full text

Abstract:

Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited antiviral activity against SARS-CoV-2, several drugs are being tested as medication or as prophylaxis to prevent infection. Using a stochastic model of early phase infection, we evaluate the success of prophylactic treatment with different drug types to prevent viral infection. We find that there exists a critical efficacy that a treatment must reach in order to block viral establishment. Treatment by a combination of drugs reduces the critical efficacy, mos

APA, Harvard, Vancouver, ISO, and other styles

12

Kindler, Christoph H., Davide Verotta, Andrew T. Gray, Michael A. Gropper, and C. Spencer Yost. "Additive Inhibition of Nicotinic Acetylcholine Receptors by Corticosteroids and the Neuromuscular Blocking Drug Vecuronium." Anesthesiology 92, no. 3 (2000): 821–32. http://dx.doi.org/10.1097/00000542-200003000-00026.

Full text

Abstract:

Background Neuromuscular disorders associated with muscular weakness and prolonged paralysis are common in critically ill patients. Acute myopathy has been described in patients receiving a combination therapy of corticosteroids and nondepolarizing neuromuscular blocking drugs for treatment of acute bronchospasm. The cause of this myopathy is not fully established and may involve drug interactions that perturb neuromuscular transmission. To investigate the interaction of corticosteroids with neuromuscular blocking drugs, the authors determined the effects of methylprednisolone and hydrocortiso

APA, Harvard, Vancouver, ISO, and other styles

13

Bergquist, Robert, and Hala Elmorshedy. "Artemether and Praziquantel: Origin, Mode of Action, Impact, and Suggested Application for Effective Control of Human Schistosomiasis." Tropical Medicine and Infectious Disease 3, no. 4 (2018): 125. http://dx.doi.org/10.3390/tropicalmed3040125.

Full text

Abstract:

The stumbling block for the continued, single-drug use of praziquantel (PZQ) against schistosomiasis is less justified by the risk of drug resistance than by the fact that this drug is inactive against juvenal parasites, which will mature and start egg production after chemotherapy. Artemisinin derivatives, currently used against malaria in the form of artemisinin-based combination therapy (ACT), provide an opportunity as these drugs are not only active against malaria plasmodia, but surprisingly also against juvenile schistosomes. An artemisinin/PZQ combination would be complimentary, and pot

APA, Harvard, Vancouver, ISO, and other styles

14

Pirrone, Vanessa, Nina Thakkar, Jeffrey M. Jacobson, Brian Wigdahl, and Fred C. Krebs. "Combinatorial Approaches to the Prevention and Treatment of HIV-1 Infection." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 1831–42. http://dx.doi.org/10.1128/aac.00976-10.

Full text

Abstract:

ABSTRACTThe discovery of the human immunodeficiency virus type 1 (HIV-1) in 1982 soon led to the identification and development of antiviral compounds to be used in treatment strategies for infected patients. Early in the epidemic, drug monotherapies frequently led to treatment failures because the virus quickly developed resistance to the single drug. Following the advent of highly active antiretroviral therapy (HAART) in 1995, dramatic improvements in HIV-1-infected patient health and survival were realized as more refined combination therapies resulted in reductions in viral loads and incre

APA, Harvard, Vancouver, ISO, and other styles

15

Pinskiy, Ilya, and Muhammad Anas. "THE ROLE OF MIRNAS IN THE DEVELOPMENT OF HUMAN BIPOLAR DISORDER." Experimental Biology 100, no. 3 (2024): 176–97. http://dx.doi.org/10.26577/bb.2024.v100.i3.015.

Full text

Abstract:

Bipolar disorder is a mental disease expressed in repeating maniac, depressive and euthymic phases of human behaviour. Different studies have found that changes in the expression or mutations of specific genes are involved in the progress of this disease. These genes encode the proteins participating in the transmission of nerve impulses (such as mediators, ion channels, etc.), endocrine regulation of mood and other processes. As we know, the expression of many human protein-coding genes is regulated on the post-transcriptional level by miRNAs (microRNAs) binding with mRNAs of the genes and bl

APA, Harvard, Vancouver, ISO, and other styles

16

Muthui, Michelle K., Polycarp Mogeni, Kennedy Mwai, et al. "Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort." Wellcome Open Research 4 (April 5, 2019): 66. http://dx.doi.org/10.12688/wellcomeopenres.15186.1.

Full text

Abstract:

Background: Interventions to block malaria transmission from humans to mosquitoes are currently in development. To be successfully implemented, key populations need to be identified where the use of these transmission-blocking and/or reducing strategies will have greatest impact. Methods: We used data from a longitudinally monitored cohort of children from Kilifi county located along the Kenyan coast collected between 1998-2016 to describe the distribution and prevalence of gametocytaemia in relation to transmission intensity, time and age. Data from 2,223 children accounting for 9,134 person-

APA, Harvard, Vancouver, ISO, and other styles

17

Muthui, Michelle K., Polycarp Mogeni, Kennedy Mwai, et al. "Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort." Wellcome Open Research 4 (May 28, 2019): 66. http://dx.doi.org/10.12688/wellcomeopenres.15186.2.

Full text

Abstract:

Background:Interventions to block malaria transmission from humans to mosquitoes are currently in development. To be successfully implemented, key populations need to be identified where the use of these transmission-blocking and/or reducing strategies will have greatest impact.Methods:We used data from a longitudinally monitored cohort of children from Kilifi county located along the Kenyan coast collected between 1998-2016 to describe the distribution and prevalence of gametocytaemia in relation to transmission intensity, time and age. Data from 2,223 children accounting for 9,134 person-yea

APA, Harvard, Vancouver, ISO, and other styles

18

Cai, Mengzhi, Yanli Hao, Jianxin Zhong, et al. "Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study." Canadian Journal of Gastroenterology and Hepatology 2019 (July 9, 2019): 1–9. http://dx.doi.org/10.1155/2019/9046260.

Full text

Abstract:

Purpose. To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy. Methods. A total of 651 pregnant women aged 18-40 in Nantong Third People’s Hospital and Hospital affiliated to Nantong University with positive hepatitis B surface antigen (HBsAg) and HBV DNA were enrolled between January 2011 and December 2015. Patients with HBV DNA≥106 copies/mL (n=251) received LdT during late pregnancy according to the patients’ will, while 136 high viral patients with HBV DNA≥106 copies/mL who did not take LdT therapy

APA, Harvard, Vancouver, ISO, and other styles

19

Lucantoni, Leonardo, Sandra Duffy, Sophie H. Adjalley, David A. Fidock, and Vicky M. Avery. "Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay." Antimicrobial Agents and Chemotherapy 57, no. 12 (2013): 6050–62. http://dx.doi.org/10.1128/aac.00870-13.

Full text

Abstract:

ABSTRACTThe design of new antimalarial combinations to treatPlasmodium falciparuminfections requires drugs that, in addition to resolving disease symptoms caused by asexual blood stage parasites, can also interrupt transmission to the mosquito vector. Gametocytes, which are essential for transmission, develop as sexual blood stage parasites in the human host over 8 to 12 days and are the most accessible developmental stage for transmission-blocking drugs. Considerable effort is currently being devoted to identifying compounds active against mature gametocytes. However, investigations on the dr

APA, Harvard, Vancouver, ISO, and other styles

20

Stefanidou, Martha, Carolina Herrera, Naomi Armanasco, and Robin J. Shattock. "Saquinavir Inhibits Early Events Associated with Establishment of HIV-1 Infection: Potential Role for Protease Inhibitors in Prevention." Antimicrobial Agents and Chemotherapy 56, no. 8 (2012): 4381–90. http://dx.doi.org/10.1128/aac.00399-12.

Full text

Abstract:

ABSTRACTThe maturation of newly formed human immunodeficiency virus type 1 (HIV-1) virions is a critical step for the establishment of productive infection. We investigated the potential of saquinavir (SQV), a protease inhibitor (PI) used in highly active antiretroviral therapy (HAART), as a candidate microbicide. SQV inhibited replication of clade B and clade C isolates in a dose-dependent manner in all cellular models tested: PM-1 CD4 T cells, peripheral blood mononuclear cells (PBMCs), monocyte-derived macrophages (MDMs), and immature monocyte-derived dendritic cells (iMDDCs). SQV also inhi

APA, Harvard, Vancouver, ISO, and other styles

21

Suhadi Suhadi, Heni Purwaningsih, and Oneys Syekh Putra. "Pengaruh Pemberian Head Up terhadap Nyeri Kepala Pasien Pasca Operasi dengan Spinal Anestesi." Jurnal Rumpun Ilmu Kesehatan 2, no. 2 (2022): 197–207. https://doi.org/10.55606/jrik.v2i2.4658.

Full text

Abstract:

Background: Spinal anesthesia is a type of extensive nerve block by inserting a local anesthetic drug into the subarachnoid space at the lumbar level (Rehatta, 2019). This method produces anesthesia by blocking transmission, deactivating motor and sensory abilities, thus creating loss of pain sensation in the perineum. lower abdomen to lower extremities. Among the effects of spinal anesthesia that often occur, post-spinal anesthesia headache is a complication that often does not receive special attention. Due to the minor effects of spinal anesthesia. Management of headaches after spinal anest

APA, Harvard, Vancouver, ISO, and other styles

22

Liu, Mingying, Yu Zhang, Xuewei Ma, et al. "Synthesis and Characterization of Fucoidan-Chitosan Nanoparticles Targeting P-Selectin for Effective Atherosclerosis Therapy." Oxidative Medicine and Cellular Longevity 2022 (September 9, 2022): 1–27. http://dx.doi.org/10.1155/2022/8006642.

Full text

Abstract:

Atherosclerosis is the key pathogenesis of cardiovascular diseases; oxidative stress, which is induced by the generated excess reactive oxygen species (ROS), has been a crucial mechanism underlying this pathology. Nanoparticles (NPs) represent a novel strategy for the development of potential therapies against atherosclerosis, and multifunctional NPs possessing antioxidative capacities hold promise for amelioration of vascular injury caused by ROS and for evading off-target effects; materials that are currently used for NP synthesis often serve as vehicles that do not possess intrinsic biologi

APA, Harvard, Vancouver, ISO, and other styles

23

da Silva, Sydnei M., Izabela F. G. Amorim, Raul R. Ribeiro, et al. "Efficacy of Combined Therapy with Liposome-Encapsulated Meglumine Antimoniate and Allopurinol in Treatment of Canine Visceral Leishmaniasis." Antimicrobial Agents and Chemotherapy 56, no. 6 (2012): 2858–67. http://dx.doi.org/10.1128/aac.00208-12.

Full text

Abstract:

ABSTRACTAn innovative liposomal formulation of meglumine antimoniate (LMA) was recently reported to promote both long-term parasite suppression and reduction of infectivity to sand flies in dogs with visceral leishmaniasis. However, 5 months after treatment, parasites were still found in the bone marrow of all treated dogs. In order to improve treatment with LMA, the present study aimed to evaluate its efficacy in combination with allopurinol. Mongrel dogs naturally infected withLeishmania infantumwere treated with six doses of LMA (6.5 mg Sb/kg of body weight/dose) given at 4-day intervals, p

APA, Harvard, Vancouver, ISO, and other styles

24

Zhao, Boxian, Chen Shen, Zhixing Zheng, et al. "Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking." Cellular Physiology and Biochemistry 51, no. 4 (2018): 1566–83. http://dx.doi.org/10.1159/000495646.

Full text

Abstract:

Background/Aims: Glioblastoma multiforme (GBM) is the most devastating and widespread primary central nervous system tumour in adults, with poor survival rate and high mortality rates. Existing treatments do not provide substantial benefits to patients; therefore, novel treatment strategies are required. Peiminine, a natural bioactive compound extracted from the traditional Chinese medicine Fritillaria thunbergii, has many pharmacological effects, especially anticancer activities. However, its anticancer effects on GBM and the underlying mechanism have not been demonstrated. This study was con

APA, Harvard, Vancouver, ISO, and other styles

25

Liao, Yan, Yue Yang, Di Pan та ін. "HSP90α Mediates Sorafenib Resistance in Human Hepatocellular Carcinoma by Necroptosis Inhibition under Hypoxia". Cancers 13, № 2 (2021): 243. http://dx.doi.org/10.3390/cancers13020243.

Full text

Abstract:

As one of the most common malignancies worldwide, Hepatocellular carcinoma (HCC) has been treated by Sorafenib, which is the first approved target drug by FDA for advanced HCC. However, drug resistance is one of the obstacles to its application. As a typical characteristic of most solid tumors, hypoxia has become a key cause of resistance to chemotherapy and radiotherapy. It is important to elucidate the underlying mechanisms of Sorafenib resistance under hypoxia. In this study, the morphological changes of hepatocellular carcinoma cells were observed by Live Cell Imaging System and Transmissi

APA, Harvard, Vancouver, ISO, and other styles

26

Liao, Yan, Yue Yang, Di Pan та ін. "HSP90α Mediates Sorafenib Resistance in Human Hepatocellular Carcinoma by Necroptosis Inhibition under Hypoxia". Cancers 13, № 2 (2021): 243. http://dx.doi.org/10.3390/cancers13020243.

Full text

Abstract:

As one of the most common malignancies worldwide, Hepatocellular carcinoma (HCC) has been treated by Sorafenib, which is the first approved target drug by FDA for advanced HCC. However, drug resistance is one of the obstacles to its application. As a typical characteristic of most solid tumors, hypoxia has become a key cause of resistance to chemotherapy and radiotherapy. It is important to elucidate the underlying mechanisms of Sorafenib resistance under hypoxia. In this study, the morphological changes of hepatocellular carcinoma cells were observed by Live Cell Imaging System and Transmissi

APA, Harvard, Vancouver, ISO, and other styles

27

Camarero-Hoyos, Claudia, Inés Bouzón-Arnáiz, Yunuen Avalos-Padilla, et al. "Leveraging the Aggregated Protein Dye YAT2150 for Malaria Chemotherapy." Pharmaceutics 16, no. 10 (2024): 1290. http://dx.doi.org/10.3390/pharmaceutics16101290.

Full text

Abstract:

Background/Objectives: YAT2150 is a first-in-class antiplasmodial compound that has been recently proposed as a new interesting drug for malaria therapy. Methods/Results: The fluorescence of YAT2150 rapidly increases upon its entry into Plasmodium, a property that can be of use for the design of highly sensitive diagnostic approaches. YAT2150 blocks the in vitro development of the ookinete stage of Plasmodium and, when added to an infected blood meal, inhibits oocyst formation in the mosquito. Thus, the compound could possibly contribute to future transmission-blocking antimalarial strategies.

APA, Harvard, Vancouver, ISO, and other styles

28

Suresh, Parepalli. "Green tea extract and hydroxyl-chloroquine combination enhances apoptosis in A549 non-small cell lung cancer cells." Bioinformation 19, no. 8 (2023): 860–66. http://dx.doi.org/10.6026/97320630019860.

Full text

Abstract:

Polyphenols, including catechins from green tea extract, have long been known for their potential anti-tumour activities. However, the precise mechanisms underlying their actions remain unclear. This study aimed to investigate the effects of green tea extract on A549 cells, a type of non-small lung cancer cells. A549 cells treated with green tea extract (GTE) were examined using an inverted light microscope and a fluorescence microscope. Cell sensitivity was evaluated using the MTT assay, while cell death was assessed using the Tali image-based cytometer. Ultra structural changes were observed

APA, Harvard, Vancouver, ISO, and other styles

29

Kleinpeter, Alex B., and Eric O. Freed. "HIV-1 Maturation: Lessons Learned from Inhibitors." Viruses 12, no. 9 (2020): 940. http://dx.doi.org/10.3390/v12090940.

Full text

Abstract:

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and effective therapies has accompanied a massive increase in our understanding of the fundamental processes that drive HIV biology. As basic HIV research has informed the development of novel therapies, HIV inhibitors have been used as probes for investigating basic mechanisms of HIV-1 replication, transmission, and pathogenesis. This positive feedback cycle has led to the development of highly effective combination antiretroviral therapy (cART), which has helped stall the progression to AIDS, prolong lives, and r

APA, Harvard, Vancouver, ISO, and other styles

30

Ouyang, Conghao. "Exploring disease therapeutic strategies by modulating the TNF-/NF-KB signalling pathway." Theoretical and Natural Science 44, no. 1 (2024): 235–44. http://dx.doi.org/10.54254/2753-8818/44/20240868.

Full text

Abstract:

In recent years, the number of patients with rheumatic diseases such as ankylosing spondylitis has been increasing, with over 3 million young people suffering from the disease. One main causal factor for these diseases is tumour necrosis factor-a (TNF-a), a pro-inflammatory cytokine that triggers mutations and apoptosis of various cell types by activating multiple signalling pathways. NF-KB is an essential intracellular nuclear transcription factor that participates in the inflammatory and immune responses of the organism and regulates apoptosis and stress responses. Excessive activation of NF

APA, Harvard, Vancouver, ISO, and other styles

31

Lu, Angela, Brandon Ebright, Aditya Naik, et al. "Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study." International Journal of Molecular Sciences 25, no. 4 (2024): 2061. http://dx.doi.org/10.3390/ijms25042061.

Full text

Abstract:

The emergence and mutation of pathogenic viruses have been occurring at an unprecedented rate in recent decades. The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into a global public health crisis due to extensive viral transmission. In situ RNA mapping has revealed angiotensin-converting enzyme 2 (ACE2) expression to be highest in the nose and lower in the lung, pointing to nasal susceptibility as a predominant route for infection and the cause of subsequent pulmonary effects. By blocking viral attachment and

APA, Harvard, Vancouver, ISO, and other styles

32

Zivny, Jan, Pavel Klener, Pavel Prochazka, et al. "Genome-Wide and Functional Analysis of Acquired Resistance to TRAIL/APO2l Mediated Apoptosis of Leukemia Cell Lines." Blood 108, no. 11 (2006): 4385. http://dx.doi.org/10.1182/blood.v108.11.4385.4385.

Full text

Abstract:

Abstract BACKGROUND: Acute leukemia comprises malignant diseases of clonal character, to which specific treatment remains limited. Apoptosis induced by death receptor activation (i.e. by tumor necrosis factor-related apoptosis inducing ligand, TRAIL/APO2L) represents a potential method for cancer therapy. A loss of sensitivity to apoptosis represents one of the key molecular mechanisms of cancer cell resistance to chemo/immuno/radiotherapy. TRAIL, a member of the TNF family of death ligands, appears to specifically and efficiently kill tumor cells of diverse origin while sparing normal tissues

APA, Harvard, Vancouver, ISO, and other styles

33

Kamelia Sinaga, Rolasnih Lilista Simbolon, Asnita Sinaga, and Riza Novianti. "Pengaruh Terapi Kompres Hangat pada Tempat Penyuntikan terhadap Respon Nyeri pada Bayi Saat Imunisasi DPT Combo di PMB Pera Tahun 2025." Jurnal Ilmiah Kedokteran dan Kesehatan 4, no. 1 (2025): 124–33. https://doi.org/10.55606/klinik.v4i1.4574.

Full text

Abstract:

According to WHO data (2023), global DPT immunization coverage has decreased due to the impact of the COVID-19 pandemic. Around 25 million children worldwide have not received complete DPT immunization in 2022, which is the highest figure in the last decade. Meanwhile, the 2023 Indonesian Health Profile noted that the coverage of complete DPT-HB-Hib immunization doses (three times) has only reached 85.3%, still below the national target of 95% (WHO, 2023). Giving warm compresses to babies who receive DPT immunization injections can cause a warm, comfortable and calming effect, in the form of t

APA, Harvard, Vancouver, ISO, and other styles

34

Ognjanović, Miloš, Marko Bošković, Hristo Kolev, Biljana Dojčinović, Sanja Vranješ-Đurić, and Bratislav Antić. "Synthesis, Surface Modification and Magnetic Properties Analysis of Heat-Generating Cobalt-Substituted Magnetite Nanoparticles." Nanomaterials 14, no. 9 (2024): 782. http://dx.doi.org/10.3390/nano14090782.

Full text

Abstract:

Here, we present the results of the synthesis, surface modification, and properties analysis of magnetite-based nanoparticles, specifically Co0.047Fe2.953O4 (S1) and Co0.086Fe2.914O4 (S2). These nanoparticles were synthesized using the co-precipitation method at 80 °C for 2 h. They exhibit a single-phase nature and crystallize in a spinel-type structure (space group Fd3¯m). Transmission electron microscopy analysis reveals that the particles are quasi-spherical in shape and approximately 11 nm in size. An observed increase in saturation magnetization, coercivity, remanence, and blocking temper

APA, Harvard, Vancouver, ISO, and other styles

35

Gonzalez-Martinez, David, Lee Roth, Thomas Mumford, et al. "Abstract 848: Inhibition of RTK fusion condensates enhances signal perception and promotes drug tolerance." Cancer Research 82, no. 12_Supplement (2022): 848. http://dx.doi.org/10.1158/1538-7445.am2022-848.

Full text

Abstract:

Abstract Drug resistance remains a significant obstacle in the successful treatment of cancer, highlighting the critical need to understand how oncogenes and cancer drugs impact cell physiology and resistance development. EML4-ALK is a receptor tyrosine kinase (RTK) fusion oncogene that drives 3-7% of lung cancer. Despite potent ALK inhibitors, EML4-ALK+ cancers frequently develop resistance during therapy. Recently, it was discovered that EML4-ALK and other RTK fusions form cytoplasmic protein condensates, and that condensate formation was required for oncogenic signaling. However, whether on

APA, Harvard, Vancouver, ISO, and other styles

36

Chitrakar, Chandani, Eric Hedrick, Lauren Adegoke, and Melanie Ecker. "Flexible and Stretchable Bioelectronics." Materials 15, no. 5 (2022): 1664. http://dx.doi.org/10.3390/ma15051664.

Full text

Abstract:

Medical science technology has improved tremendously over the decades with the invention of robotic surgery, gene editing, immune therapy, etc. However, scientists are now recognizing the significance of ‘biological circuits’ i.e., bodily innate electrical systems for the healthy functioning of the body or for any disease conditions. Therefore, the current trend in the medical field is to understand the role of these biological circuits and exploit their advantages for therapeutic purposes. Bioelectronics, devised with these aims, work by resetting, stimulating, or blocking the electrical path

APA, Harvard, Vancouver, ISO, and other styles

37

Filkova, A. A., M. A. Panteleev, and A. N. Sveshnikova. "Reversible platelet aggregation in the presence of calcium ions: mechanisms and potential value." Pediatric Hematology/Oncology and Immunopathology 18, no. 3 (2019): 120–29. http://dx.doi.org/10.24287/1726-1708-2019-18-3-120-129.

Full text

Abstract:

Disorders in the functions of platelets – blood cells responsible for the blood clots formation and prevention – are observed as independent diseases, as a complication of cancer and hematological diseases or as a result of a therapy. Nowadays, a test of platelet aggregation by aggregometry is the only diagnostic method for assessing the platelets functions. There are several varieties of aggregometry, which differ both in the method of recording the formation of platelet aggregates and in the method of preparing platelets for the experiment. In most laboratories, it is customary to conduct ag

APA, Harvard, Vancouver, ISO, and other styles

38

Li, Qigui, Lisa H. Xie, Jing Zhang, and Brandon S. Pybus. "Identification and Assessment of Plasmodium berghei Merozoites and Cell Cycle by Flow Cytometry." Military Medicine 186, Supplement_1 (2021): 108–15. http://dx.doi.org/10.1093/milmed/usaa272.

Full text

Abstract:

ABSTRACT Background The asexual blood stages of the Plasmodium berghei life cycle including merozoites are attractive targets for transmission blocking vaccines and drugs. Improved understanding of P. berghei life cycle stage growth and development would provide new opportunities to evaluate antimalarial vaccines and drugs. Methods Blood stage samples from C57BL/6 albino mice infected with P. berghei sporozoites were singly stained with a high binding affinity deoxyribonucleic acid dye, YOYO-1, and measured by flow cytometry (FCM). Duplicate slides were made from samples and stained with dilut

APA, Harvard, Vancouver, ISO, and other styles

39

Bossowska, A., and M. Majewski. "Botulinum toxin type A-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder." Polish Journal of Veterinary Sciences 15, no. 2 (2012): 345–53. http://dx.doi.org/10.2478/v10181-012-0053-z.

Full text

Abstract:

Botulinum toxin type A-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder Botulinum toxin type A (BTX) is a potent neurotoxin, which in recent years has been effectively applied in experimental treatments of many neurogenic disorders of the urinary bladder. BTX is a selective, presynaptically-acting blocking agent of acetylcholine release from nerve terminals what, in turn, leads to the cessation of somatic motor and/or parasympathetic transmission. However, application of this toxin in urological practice is still in the developmental

APA, Harvard, Vancouver, ISO, and other styles

40

Mann, Ruth, Manfred Blobner, Sabine Jelen-Esselborn, Raimund Busley, and Christian Werner. "Preanesthetic Train-of-four Fade Predicts the Atracurium Requirement of Myasthenia Gravis Patients." Anesthesiology 93, no. 2 (2000): 346–50. http://dx.doi.org/10.1097/00000542-200008000-00011.

Full text

Abstract:

Background The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) &lt; 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing neuromuscular blocking agents compared with myasthenia gravis patients with preanesthetic T4/T1 &gt; or = 0.9. Methods After institutional review board approval was obtained, 20 electrophysiologically documented myasthenia gravis patients were studied. Current pyridost

APA, Harvard, Vancouver, ISO, and other styles

41

Wu, Shih-Ying, Kerui Wu, Abhishek Tyagi, et al. "Abstract 2585: GABA shunt pathway promotes peri-synaptic brain metastasis by hijacking synaptic signaling." Cancer Research 85, no. 8_Supplement_1 (2025): 2585. https://doi.org/10.1158/1538-7445.am2025-2585.

Full text

Abstract:

Abstract Metastatic brain tumors are the most common intracranial neoplasms in adults. Among all subtypes of breast cancer, triple-negative breast cancer (TNBC) has a significantly poorer prognosis compared to other subtypes. Pre-menopause and estrogen replacement therapy after menopause have been shown to increase the risk of brain metastases in TNBC patients. Estrogen blockade using tamoxifen demonstrates some efficacy in TNBC, suggesting that estrogen promotes brain metastases by modulating the tumor microenvironment in estrogen receptor (ER)-negative tumors. Neurons, as highly specialized

APA, Harvard, Vancouver, ISO, and other styles

42

Trybus, Ewa, Teodora Król, and Wojciech Trybus. "The Multidirectional Effect of Azelastine Hydrochloride on Cervical Cancer Cells." International Journal of Molecular Sciences 23, no. 11 (2022): 5890. http://dx.doi.org/10.3390/ijms23115890.

Full text

Abstract:

A major cause of cancer cell resistance to chemotherapeutics is the blocking of apoptosis and induction of autophagy in the context of cell adaptation and survival. Therefore, new compounds are being sought, also among drugs that are commonly used in other therapies. Due to the involvement of histamine in the regulation of processes occurring during the development of many types of cancer, antihistamines are now receiving special attention. Our study concerned the identification of new mechanisms of action of azelastine hydrochloride, used in antiallergic treatment. The study was performed on

APA, Harvard, Vancouver, ISO, and other styles

43

Li, Hongxia, Zhixin Wang, Lei Dong, et al. "Peptide tyrosine-tyrosine combined with its receptors exhibits an anti-cancer potential in pancreatic cancer MiaPaCa-2 cell." Chinese Medical Journal 127, no. 24 (2014): 4235–42. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20141200.

Full text

Abstract:

Background Pancreatic cancer is a common malignant tumor of the digestive system. It is the fourth major cause of tumor-related death and its morbidity is increasing, and hence it is imperative to develop effective forms of therapy for pancreatic cancer. Peptide tyrosine-tyrosine (PYY) is an important gastrointestinal peptide hormone. According to previous literatures, PYY has been shown to inhibit tumor proliferation in cellular and animal models, but there has been limited research on the detailed mechanism of PYY in pancreatic cancer. This study was to observe the effects of PYY on pancreat

APA, Harvard, Vancouver, ISO, and other styles

44

Amos, Joshua D., Jonathon E. Himes, Lawrence Armand, et al. "Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys." Journal of Virology 89, no. 18 (2015): 9485–98. http://dx.doi.org/10.1128/jvi.01564-15.

Full text

Abstract:

ABSTRACTThe initial phases of acute human immunodeficiency virus type 1 (HIV-1) infection may be critical for development of effective envelope (Env)-specific antibodies capable of impeding the establishment of the latent pool of HIV-1-infected CD4+T cells, preventing virus-induced immune hyperactivation to limit disease progression and blocking vertical virus transmission. However, the initial systemic HIV-1 Env-specific antibody response targets gp41 epitopes and fails to control acute-phase viremia. African-origin, natural simian immunodeficiency virus (SIV) hosts do not typically progress

APA, Harvard, Vancouver, ISO, and other styles

45

Duong, Ellen, Thomas D. Wu, Karl Banta, et al. "Abstract LB123: TIGIT and PD-L1 co-blockade activates type 1 conventional dendritic cells to promote non-exhausted anti-tumor CD8+ T cell immunity through enhanced costimulation." Cancer Research 85, no. 8_Supplement_2 (2025): LB123. https://doi.org/10.1158/1538-7445.am2025-lb123.

Full text

Abstract:

Abstract Background: Dual inhibition of the PD-1 and TIGIT checkpoint receptor pathways has demonstrated synergistic anti-tumor activity in preclinical studies and early clinical trials, but its mechanism(s) of action remains incompletely understood. We now know that PD-1 and TIGIT regulate CD28 and CD226 costimulatory signals and thus co-blockade presents a rational strategy to facilitate the transmission of these activating signals to T cells. However, therapeutic efficacy of the combination is contingent upon a functional anti-TIGIT Fc domain, thereby implicating a role for myeloid cells, w

APA, Harvard, Vancouver, ISO, and other styles

46

Chiou, *Lih-Chu, Chia-Chi Lu, Hsin-Jung Lee та ін. "α6GABAA RECEPTOR-SELECTIVE POSITIVE ALLOSTERIC MODULATOR AS A NOVEL THERAPY FOR ADHD: A PRECLINICAL STUDY IN MK-801- TREATED JUVENILE MICE". International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i9—i10. https://doi.org/10.1093/ijnp/pyae059.017.

Full text

Abstract:

Abstract Background The α6 subunit-containing GABAA receptors (α6GABAARs) are almost exclusively expressed in granule cells of the cerebellum in the whole brain. Their pathophysiological roles were understudied without selective ligands before. We identified a series of pyrazoloquinolinones (PQ) as α6GABAAR- selective positive allosteric modulators (PAMs) [1]. PQs display high affinity at the α+/β- interface, distinct from the GABA binding site, of GABAARs. They selectively increase the GABA current mediated by α6GABAARs among other α subunits. The cerebellum is recently implicated in several

APA, Harvard, Vancouver, ISO, and other styles

47

Urbinati, Fabrizia, Zulema Romero Garcia, Sabine Geiger та ін. "Preclinical Studies for Sickle Cell Disease Gene Therapy Using Bone Marrow CD34+ Cells Modified with a βAS3-Globin Lentiviral Vector". Blood 118, № 21 (2011): 3119. http://dx.doi.org/10.1182/blood.v118.21.3119.3119.

Full text

Abstract:

Abstract Abstract 3119 BACKGROUND: Sickle cell disease (SCD) affects approximately 80, 000 Americans, and causes significant neurologic, pulmonary, and renal injury, as well as severe acute and chronic pain that adversely impacts quality of life. Because SCD results from abnormalities in red blood cells, which in turn are produced from adult hematopoietic stem cells, hematopoietic stem cell transplant (HSCT) from a healthy (allogeneic) donor can benefit patients with SCD, by providing a source for life-long production of normal red blood cells. However, allogeneic HSCT is limited by the availa

APA, Harvard, Vancouver, ISO, and other styles

48

Swan, Christina H., Bernd Buhler, Mario P. Tschan, Carlos F. Barbas, and Bruce E. Torbett. "Lentiviral CCR5 Intrabody Gene Delivery Provides Protection and Enrichment during CCR5-Tropic Infection." Blood 104, no. 11 (2004): 1755. http://dx.doi.org/10.1182/blood.v104.11.1755.1755.

Full text

Abstract:

Abstract The molecular mechanism of human immunodeficiency virus type 1 (HIV-1) entry into target cells is a multistep mechanism. The viral envelope glycoproteins (env) binds first to CD4 and subsequently interacts with the V3 loop with a chemokine receptor, CCR5 or CXCR4, triggering the fusion event. Several findings suggest that viruses using CCR5 for entry (R5-tropic HIV-1) is the predominant species transmitted among patients. Importantly, CCR5 expression levels determine disease progression. CCR5 does not seem to be necessary for normal cell function, since individuals with a homozygous m

APA, Harvard, Vancouver, ISO, and other styles

49

Jaskula, Emilia, Janusz Lange, Mariola Sedzimirska, and Andrzej Lange. "Sorafenib Is Contributing to Salvage Chemotherapy and Is Effective Given Alone for Maintenance in AML FLT3 ITD Patients Relapsing Post Allo Hematopoietic Stem Cell Transplantation." Blood 124, no. 21 (2014): 5265. http://dx.doi.org/10.1182/blood.v124.21.5265.5265.

Full text

Abstract:

Abstract Normal karyotype AML patients with FLT3 ITD have a higher risk of relapse than those lacking this mutation (Estey EH, Am J Hematol. 2013). Our comparative genomic hybridization study (77 patients) showed that AML cases with as compared to those without FLT3 ITD had significantly lower number of amplifications or deletions (number of total CNV aberrations: 18±4 vs 51±8, p=0.003). The latter observation in concert with that of others (Thiede, Blood 2002) suggest that FLT3 ITD mutation if present in normal karyotype patients is a key player in the pathogenesis of leukaemia and targeting

APA, Harvard, Vancouver, ISO, and other styles

50

Goldberg, Michael E. "Pharmacodynamic Profiles of Ketamine (R)- and (S)- with 5-Day Inpatient Infusion for the Treatment of Complex Regional Pain Syndrome." Pain Physician 4;13, no. 4;7 (2010): 379–87. http://dx.doi.org/10.36076/ppj.2010/13/379.

Full text

Abstract:

Background: Ketamine might be effective in blocking central sensitization of pain transmission neurons through its effect on NMDA receptors in refractory Complex Regional Pain Syndrome (CRPS) patients. At higher doses, ketamine infusions can be associated with significant risks; outpatient therapy requires return visits for a 10-day period with variable efficacy and duration. Objective: This study determined the efficacy of a 5-day moderate dose, continuous racemic ketamine infusion. The pharmacodynamic responses to racemic ketamine and norketamine were examined. Design: Observational study Me

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!