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Dissertations / Theses on the topic 'Transplantatie'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 March 2023

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1

Dorp, Michiel Herman van. "HLA & transplantatie de ontwikkeling van een matchingspraktijk /." [Amsterdam : Maastricht : Thela Thesis] ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=7046.

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2

Ruers, Theodoor Jacques Marie. "Selective immunosuppression in organ transplantation." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5415.

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3

Vroemen, Joseph Pieter Anna Maria. "Hepatocyte transplantation." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1987. http://arno.unimaas.nl/show.cgi?fid=5364.

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4

Homminga, George Nicolaas. "Perichondrial arthroplasty of the knee." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5533.

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5

Wolf, Rienhart Frans Ennes. "NMR studies of the human donor liver." [Groningen] : [Groningen] : Rijksuniversiteit Groningen ; [University Library Groningen] [Host], 1996. http://irs.ub.rug.nl/ppn/149074379.

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6

Reubsaet, Astrid. "Development and evaluation of a school-based organ donation education programme." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2004. http://arno.unimaas.nl/show.cgi?fid=6047.

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7

Blok, Marinus Jacob. "Monitoring the course of CMV infection by detection of specific viral transcripts." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=7070.

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8

Hart, Nils Arnaud 't. "Improving liver preservation new strategies in liver procurement and preservation /." [S.l. : Groningen : s.n. ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/30406856X.

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9

Dor, Frank Johan Marinus Frederik. "Investigations relating to the induction of immunological tolerance through spleen transplantation in miniature swine." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2006. http://hdl.handle.net/1765/10508.

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10

Geuken, Wirtje. "Molecular changes in hepatobiliary function and injury after human liver transplantation." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/292334834.

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11

Maessen, Josephus Gregorius. "Evaluation of ischemic injury in donor kidneys an experimental study /." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5610.

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12

Bouwmeester, Sophia Johannes Maria. "Perichondrial arthroplasty of the knee results and attempts for improvement since 1986 /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=7214.

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13

Bruning, Johan Hendrik. "Cytomegalovirus infections in renal transplantation study in a rat model /." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5592.

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14

Dubelaar, Maria Louisa. "Carnitine and paced muscles improvement of vascular metabolism /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=5842.

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15

Wijnen, René Maria Henricus. "Tacrolimus (FK506) in experimental pancreas transplantation toxicology and immunology studies in the Cynomolgus monkey /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5902.

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16

Veldt, Bartholomeus Johannes. "Long-term clinical outcome of treatment for chronic hepatitis C." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/12624.

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17

Adang, Edwin Mathias Marie. "Medical technology assessment in surgery costs and effects of dynamic graciloplasty and combined pancreas kidney transplantation /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5901.

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18

Klupp, Jochen. "Untersuchungen zum Einfluss von Mycophenolat Mofetil auf die Transplantat-Vaskulopathie nach allogener Aorten-Transplantation im Primaten-Modell." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965488586.

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19

Schindewolffs, Lia [Verfasser]. "Die Transplantation autologer Lymphknotenfragmente als Therapiemöglichkeit des sekundären Lymphödems: Einfluss der VEGF-C-Applikationsparameter auf die Regeneration und den Wiederanschluss der Transplantate / Lia Schindewolffs." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://d-nb.info/1030351430/34.

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20

Bergqvist, Madeleine, and Linnéa Kjellberg. "Livet med en ny lever : patienters livskvalitet efter en levertransplantation." Thesis, Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-15671.

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Sjuksköterskan bör ha kunskap om begreppet livskvalitet för att kunna bemöta patienter som genomgått en levertransplantation, då den upplevda livskvalitén är betydelsefull för patienterna. Syftet var att beskriva livskvalitet hos patienter som genomgått en levertransplantation. Studien är genomförd som en litteraturstudie där 12 vetenskapliga artiklar har granskats. Resultatet visar att den upplevda livskvalitén hos levertransplanterade patienter är relativt god men det finns delar av livskvalitén som påverkas negativt efter levertransplantationen. Livskvalitén påverkas av fysiska, psykiska och sociala aspekter. De delar som påverkade livskvalitén positivt var familjen, att kunna återvända till det yrkesverksamma livet och att få en chans till ett nytt liv. Negativa aspekter som framkom i resultatet var bland annat förlorad autonomi, fysisk inaktivitet och en känsla av utanförskap i samhället. Vidare omvårdnadsforskning inom området livskvalitet relaterat till levertransplantation bör utföras. Sjuksköterskor behöver utbildning i ämnet för att i omvårdnadsarbetet kunna främja och bevara patienters livskvalitet.
The nurse should have knowledge of the concept of quality of life to respond to patients who underwent a liver transplant, when the perceived quality of life is important for patients. The aim was to describe the quality of life in patients undergoing a liver transplant. The study was conducted as a literature review of 12 scientific papers that have been reviewed. The results show that the perceived quality of life in liver transplant patients is relatively good but there are elements of quality of life adversely affected by post-liver transplant. Quality of life is affected by physical, psychological and social aspects. The elements affecting the quality of life positively were the family, ability to return to the working life and to get a chance to start a new life. Negative aspects that emerged from the results included the loss of autonomy, physical inactivity and a sense of alienation in society. In addition, nursing research in the field of quality of life related to liver transplantation should be performed. Nurses need education on the topic of the nursing work to promote and preserve patients' quality of life.

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21

Mari, Elisabeth Rose. "Factors affecting the induction of transplantation tolerance in bone marrow transplantation." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9919.

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The engraftment of allogeneic haematopoietic stem cells (HSC) relies on the use partially or fully myeloablative regimens to condition the transplant recipient in order to “make space” in the bone marrow microenvironment and establish immunological tolerance to donor alloantigens. In murine models of bone marrow transplantation where donor-recipient pair differ for a single minor histocompatibility (H) antigen, HY, engraftment can be obtained using low-dose irradiation. Such conditioning favours the homeostatic expansion of regulatory (Treg) cells that play a crucial role in generating host versus graft tolerance (HvG). However, the HY model has some limitations because, in the clinical setting, HLA-matched donor and recipient still differ for several minor H antigens. Although there is evidence that immune responses across minor H differences concentrate on immunodominant epitopes, it was fundamental to understand whether increasing the number of donor antigenic disparities necessitated a proportional increment in the dose of conditioning to achieve engraftment. I utilised a bone marrow transplantation model in which donor and recipient differed for multiple minor H antigens and whereby immune responses were prominently skewed against a single immunodominant epitope. Recipient mice were C57BL/6 and bone marrow was obtained from BALB.B donors, whereby the immunodominant epitope was H60. My results showed that low-dose irradiation was not sufficient to obtained BALB.B donor cell engraftment but a fully myeloablative dose of (850cGy) was required. When the amount of antigenic determinants was decreased, by transplanting (BALB.BxC57BL/6) F1 cells, donor cell engraftment was achieved at an irradiation dose of 500cGy. These data show that the dose of conditioning regimen required for engraftment is proportional to the magnitude of the antigenic differences across donor and recipient. Different doses of myeloablation certainly bear different impacts on the depletion of lymphocyte subsets and lympho-haemopoietic reconstitution. Therefore, I investigated the kinetics and extent of Treg expansion. In all groups of transplanted mice the engrafted mice had significantly increased proportions of Treg cells which peaked during the second week post-transplant. When host Treg cells were depleted prior to transplantation with male C57BL/6 or (BALB.BxC57BL/6) F1 donor bone marrow under irradiated at 500cGy or 600cGy, the level of donor cell engraftment was not affected. However, there was a delay in the engraftment of (BALB.BxC57BL/6) F1 bone marrow, thus suggesting a marginal role for Treg cells using higher doses of conditioning. These data imply that the magnitude of antigenic disparities between the donor and recipient deeply impacts on the dose of irradiation required to obtain durable engraftment. The dose of irradiation does not correlate with the level of Treg cell expansion and Treg depletion only marginally affects engraftment. These data indicate that, in the presence of multiple antigenic disparities, depletion of T cell effecting HvG responses rather than induction of immune regulation is necessary.

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22

Huda, Amina. "Employment after liver transplantation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398878.

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23

Lord, Stephen. "Reinnervation after cardiac transplantation." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410568.

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24

Schafer, Donna. "Hyperlipidemia post heart transplantation." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69770.

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Hyperlipidemia is prevalent following heart transplantation, and may play a role in the development of late graft atherosclerosis. The charts of 35 heart transplant recipients (n = 32 males and 3 females) were reviewed retrospectively up until three years post transplantation, to describe a time-course of hypercholesterolemia after transplantation, and to determine the mechanisms involved in its pathogenesis. All patients received prednisone, cyclosporine, and azathioprine for immunosuppression. A progressive rise in both serum cholesterol (2.4 $ pm$ 0.4 mmol/l, p $<$ 0.01), and body weight (8.4 $ pm$ 1.6 kg, p $<$ 0.01) were observed during the first 8 and 10 months respectively. Levels stabilized thereafter, remaining above pretransplant levels. Triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol concentrations were all above normal limits following transplantation. Tapering of prednisone dose had a significant effect on serum cholesterol levels, whereas diet had a beneficial effect on body weight. A randomized, controlled, dietary intervention study then followed to further assess the effect of dietary intervention on minimizing or preventing post transplantation hyperlipidemia and weight gain. Five patients were counselled the Step One Lipid-Lowering diet, two patients were controls. All study patients demonstrated a lower overall increase in serum cholesterol levels than other transplant recipients. Reported nutritional intakes were similar between both groups. Increases in body weight were related to increases in body fat. Patients in the diet group demonstrated improvements in their level of nutrition knowledge, which correlated with lower serum cholesterol levels. Changes in serum cholesterol were also associated with appetite, hunger, perceived interest, perceived benefits, perceived barriers, and attitudes toward food. Changes in body weight were associated with appetite, hunger, perceived barriers, and stress. As

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25

Honey, Karen J. "Mechanisms of transplantation tolerance." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301519.

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26

Wise, Matt. "Mechanisms of transplantation tolerance." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242039.

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27

Jamieson, N. V. "Liver preservation for transplantation." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605054.

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28

Scully, Ralph. "Mechanisms in transplantation tolerance." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321084.

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29

Bentall, Andrew John. "Antibodies in kidney transplantation." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5817/.

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The aim of this thesis is to examine the effect of anti-donor antibodies in the clinical management and outcomes of antibody incompatible kidney transplantation. Initial studies were conducted to improve measurement of anti-ABO specific blood group antibodies. The specificity of antibody binding to blood group antigens (BGA) depended upon the assay platform and the nature of the core structure to which the BGA was bound. A standardised haemagglutination assay had excellent reproducibility, which was then applied to the analysis of samples derived from a study of 100 ABO incompatible kidney transplantation (ABOiKTx) in the UK where good clinical outcomes were achieved but there was wide variation reported in local assays quantifying BGA specific antibodies, without survival differences. In a highly sensitised HLA incompatible kidney transplant recipients (HLAiKTx), I demonstrated long term outcomes were poor compared to a compatible cohort, in particular with pre-formed donor specific anti-HLA Class II antibodies, in which histological injury of antibody damage occurred significantly earlier than with Class I antibodies. Further studies demonstrated that anti-HLA antibodies were associated with an inflammatory phenotype, but anti-donor ABO specific antibodies did not despite the activation of complement. Thus, inhibiting terminal complement activation, whilst reducing early antibody-mediated rejection did not abrogate all inflammation which was associated with the presence of IgM DSA. Reproducible and standardised assays are needed for antibody assessment in order to make good clinical decisions to improve patient outcomes. Further studies are needed to stop production or block mechanisms of ongoing cellular infiltrate to improve patient outcomes.

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30

Desai, Rajeev Ramarao. "Organ transplantation related cancer." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6907/.

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Cancer is an important cause of mortality among the recipients of organ transplantation. Cancer transmitted from the donors has poor outcome and the fear of such transmission results in non-acceptance of certain organs. Study of the recipients in the UK over 10 years identified 15 cases of transmitted cancers. The rate of cancer transmission was 0.05%.The risk of cancer transmission was 9 times higher from donors older than 45 years. A comparison of the organ donor data with the guidelines classifying the donor’s risk showed that a selected cohort of donors, who are classed as high risk of cancer transmission, could safely donate their organs resulting in valuable additional survival for the recipients, with low risk of cancer transmission. These results provide evidence, for modification of donor classification guidelines resulting in increased availability of safe organs for transplantation. The risk of recurrence after transplantation of cancers treated before transplantation was low in selected recipients undergoing transplantation after a 2 year-wait following the diagnosis of cancer. No association was found between the donor-recipient CMV status and the risk of post-transplant cancer. This research estimated the risk of cancer transmission to the organ transplant recipients enabling improved risk assessment in transplantation.

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31

Fabre, Jean-Michel. "Métabolisme hépatique et transplantation." Montpellier 1, 1994. http://www.theses.fr/1994MON1T013.

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32

POLLET, BEATRICE. "Transplantation cardiaque et grossesse." Lyon 1, 1991. http://www.theses.fr/1991LYO1M239.

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33

Legrand, Éric. "Polyglobulie apres transplantation renale." Nancy 1, 1991. http://www.theses.fr/1991NAN11192.

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34

Quteineh, Lina. "Pharmacogénétique en transplantation rénale." Paris 6, 2008. http://www.theses.fr/2008PA066229.

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1) Étude du polymorphisme génétique de la vitamine K époxyde réductase (VKORC1) et le risque de surdosage en anti-vitamine K (AVK). Précédemment, nous avons réalisé une étude prospective de type cas-témoin dans le but de d’identifier des facteurs de risque de surdosage en AVK. La même population a été ré-analysée, en ajoutant un nouveau facteur génétique (VKORC1 1173C>T). Nous avons montré dans cette étude que le risque de surdosage est significativement plus important chez les patients 1173TT et les patients 1173CT comparativement aux patients 1173CC avec un risque relatif de 10,5 et 2,3 respectivement. 2) Étude des facteurs génétiques de survenue de rejet aigu et des facteurs prédictifs de la fonction à long terme du greffon en transplantation rénale. A partir d’une cohorte de 288 patients transplantés, nous avons montré, dans un premier temps, que la fonction à long terme des greffons était supérieure chez les patients porteurs de l’haplotype VKORC1*2/*2 que chez les non porteurs (HR: 0. 34, 95% CI: 0. 26 - 0. 87, P=0. 02). Dans un second temps, nous avons pu identifier une association entre le polymorphisme génétique de CYP3A5 et la posologie quotidienne du tacrolimus et la survenue de rejet aigu au cours de la première année de greffe. Dans une population de 136 patients transplantés rénaux, nous avons montré que les sujets porteurs d’au moins un allèle CYP3A5*1 avaient besoin une posologie plus importante du tacrolimus pour atteindre une concentration à l’état d’équilibre. A 1 mois post-greffe, l’incidence de rejet aigu était plus importante chez les sujets porteurs de deux allèles CYP3A5*1 que les non porteurs (38% et 10% respectivement).

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35

Lepoivre, Hélène. "Grossesse après transplantation rénale." Caen, 1990. http://www.theses.fr/1990CAEN3085.

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36

LACAILLE, VERONIQUE. "Hyperlipidemie apres transplantation cardiaque." Dijon, 1994. http://www.theses.fr/1994DIJOM075.

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37

Pummer-Verté, Lila. "Organ donation and transplantation /." Online version of thesis, 1995. http://hdl.handle.net/1850/12252.

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38

Wotherspoon, John Scott. "Studies in transplantation tolerance." Thesis, The University of Sydney, 1990. https://hdl.handle.net/2123/26352.

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The most fundamental function of the immune system is discrimination between the molecules that constitute "self" and those of foreign organisms, tissues or substances which the organism encounters during life. This immunological discrimination between self and non-self is vital to the maintenance of the biological integrity of the organism and is evident at the lowest phylogenetic levels (Hildemann et al., 1977). Encounters with molecules which are recognised as non-self trigger the immune system to initiate effector mechanisms by which the foreign molecules are eliminated. The diverse range of self molecules, however, does not apparently induce a similar response. The lack of responsiveness to self molecules, so called self-tolerance, is thought to be acquired during the development of the lymphoid system. As yet, the actual process by which the immune system distinguishes self and non-self molecules is not fully understood and remains a central issue of cellular immunology.

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39

CLAYTON, Philip. "Outcomes of Kidney Transplantation." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10553.

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Kidney transplantation is the preferred treatment for the majority of patients with end-stage kidney disease, offering improved survival and quality of life compared with dialysis at reduced cost. However, kidney transplantation remains a treatment rather than a cure. A good outcome requires appropriate donor and recipient selection, careful management of immunosuppression, and avoidance of long-term complications including death from cardiovascular disease or malignancy, and graft loss from chronic allograft nephropathy or recurrence of the primary kidney disease. Making use of data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, supplemented where necessary by other sources, this thesis contains a number of linked epidemiologic investigations: (1) a report of the risk profile of Australian and New Zealand living kidney donors over 2004-11; (2) simulations of the allocation of deceased donor kidneys in Australia over 2006-2010, and development of novel metrics for the utility and equity of each allocation system; (3) external validation of the US estimated post-transplant survival (EPTS) score; (4) study of the long-term consequences of early acute rejection; (5) 15 year follow-up of a randomised trial of mycophenolate vs azathioprine; and (6) analysis of the association between steroid use and graft loss from recurrent IgA nephropathy.

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40

Schmidt, Martin A. "Die Morbidität der Spenderareale vaskularisierter Transplantate." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=963606352.

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41

Huang, C. C. "Pathophysiology of post-transplantation bone disease : mechanisms of bone loss after orthotopic liver transplantation." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604707.

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To enhance our understanding of the pathophysiology of bone disease associated with liver transplantation and of the mechanisms underlying bone loss in the three month period following transplantation, this prospective study was undertaken as follows: (1) bone pathophysiology was evaluated pre- and three months post-transplantation in transiliac biopsies using tetracycline-assisted histomorphometry; (2) cellular activities of bone formation and resorption pre- and post- transplantation were studied using quantitative enzyme cytochemistry in combination with histomorphometric methods; (3) cellular activities for markers of bone energy metabolism and biosynthesis and/or cell proliferation were investigated using quantitative enzyme cytochemistry; (4) plasma markers for bone metabolism were investigated at regular intervals in collaboration with other laboratories. It was concluded from this study that rapid bone loss early after transplantation is due both to increased bone turnover and a negative remodelling balance at the individual bone remodelling site. These changes were at least partially mediated by increased PTH levels secondary to a negative balance in plasma calcium. Cyclosporin A is known to increase intracellular calcium levels and inhibit calcium release from mitochondria. It also reduces glomerular filtration rate which could be sufficient to depress extracellular calcium levels and thereby cause the observed rise in PTH levels. The consequences of this for post transplant bone remodelling is a markedly enhanced risk of osteoporosis in these patients. Ensuring replete calcium and vitamin D levels pre-transplantation and supplementation of cyclosporin A treatment with vitamin D metabolites and calcium post-transplantation followed by careful monitoring of plasma calcium concentrations might offer a better overall outcome for preventing transplantation-associated osteoporosis at this early stage post transplantation.

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42

BORIES, GUERIN EMMANUELLE. "Cancers secondaires apres transplantation : a propos d'un cas de cancer bronchique apres transplantation cardiaque." Rennes 1, 1993. http://www.theses.fr/1993REN1M071.

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43

Cortellazzi, Jacopo. "Code transplantation for adversarial malware." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/17288/.

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In the nefarious fight against attackers, a wide range of smart algorithms have been introduced, in order to block and even prevent new families of malware before their appearance. Machine learning, for instance, recently gained a lot of attention thanks to its ability to use generalization to possibly detect never-before-seen attacks or variants of a known one. During the past years, a lot of works have tested the strength of machine learning in the cybersecurity field, exploring its potentialities and weaknesses. In particular, various studies highlighted its robustness against adversarial attacks, proposing strategies to mitigate them . Unfortunately, all these findings have focused in testing their own discoveries just operating on the dataset at feature layer space, which is the virtual data representation space, without testing the current feasibility of the attack at the problem space level, modifying the current adversarial sample . For this reason, in this dissertation, we will introduce PRISM, a framework for executing an adversarial attack operating at the problem space level. Even if this framework focuses only on Android applications, the whole methodology can be generalized on other platforms, like Windows, Mac or Linux executable files. The main idea is to successfully evade a classifier by transplanting chunks of code, taken from a set of goodware to a given malware. Exactly as in medicine, we have a donor who donates organs and receivers who receive them, in this case, goodware applications are our donors, the organs are the needed code and the receiver is the targeted malware. In the following work we will discuss about concepts related to a wide variety of topics, ranging from machine learning, due to the target classifier, to static analysis, due to the possible countermeasures considered, to program analysis, due to the extraction techniques adopter, ending in mobile application, because the target operating system is Android.

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44

Sáez, Giménez Berta. "Venous thromboembolism after lung transplantation." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666689.

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La enfermedad tromboembólica es una complicación frecuente tras el trasplante de órgano sólido y, específicamente, tras el trasplante pulmonar. Los objetivos de nuestro trabajo fueron: describir los factores de riesgo de la enfermedad tromboembólica, evaluar el impacto de un protocolo de profilaxis extendido y describir los perfiles de coagulación antes y hasta 1 año tras el trasplante pulmonar. Con dicho objetivo llevamos a cabo dos estudios; el primero compara retrospectivamente una cohorte estudio (n=138) que recibió profilaxis con enoxaparina 90 días post-trasplante y una cohorte control histórica (n= 195) que recibió profilaxis únicamente durante el período de hospitalización post-trasplante. El segundo estudio, es un estudio prospectivo para describir el perfil de coagulación de 48 pacientes previamente al trasplante, en las primeras 24-72 horas post-trasplante, a las 2 semanas, 4 meses y 1 año post-trasplante. La incidencia de enfermedad tromboembólica en nuestra población fue del 15.3% (95% IC: 11.6-19.4). El tiempo medio del trasplante al evento fue de 40 (p25-75, 14-112) días. En este estudio, los factores de riesgo que se asociaron a la enfermedad tromboembólica fueron el género masculino y la enfermedad pulmonar intersticial difusa como enfermedad de base. La profilaxis extendida con enoxaparina no disminuyó la incidencia de enfermedad tromboembólica. En el estudio que describe los perfiles de coagulación transcurrido 1 año tras el trasplante pulmonar, encontramos que la mayor parte de marcadores de un estado procoagulante se normalizan a las 2 semanas del trasplante; sin embargo, al año todavía encontramos algunos pacientes niveles alterados de factor VIII y factor de Von Willebrand. Los pacientes que presentaron alguna complicación trombótica en los primeros 4 meses tras el trasplante, tenían niveles más elevados de factor VIII a las 2 semanas. Se necesitarán estudios multicéntricos con mayor tamaño muestral para poder diseñar estrategias profilácticas adecuadas.
Venous thromboembolism is a frequent complication after solid organ transplantation and, specifically, after lung transplantation. The objectives of this study were to describe risk factors for venous thromboembolism, to assess the impact of an extended prophylaxis protocol and to describe coagulation profiles before and up to 1 year after lung transplantation. We performed 2 studies. The first study compared a cohort (n=138) that received 90-day extended prophylaxis with enoxaparin and a historical control cohort (n= 195) that received prophylaxis only during post-transplant hospitalization. The second study is a prospective study to describe the coagulation profiles of 48 patients before lung transplantation and at 24- 72 hours, 2 weeks, 4 months and 1 year after lung transplantation. The cumulative incidence of venous thromboembolism was 15.3% (95% CI: 11.6-19.4). Median time from transplant to the event was 40 (p25-75, 14-112) days. In this study, the risk factors associated with venous thromboembolism were male gender and interstitial lung disease. Ninety-day extended prophylaxis did not reduce the incidence of VTE. In the second study to describe coagulation profiles up to 1 year after lung transplantation, we found that most markers of a procoagulant state normalize at 2 weeks after lung transplantation and that abnormal values of factor VIII and Von Willebrand factor persist at 1 year. Patients with venous thromboembolism at 4 months had higher values of factor VIII at 2 weeks. Larger, multicenter studies are needed to confirm these results and to design appropriate prophylactic strategies.

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45

Neal, David A. J. "Cardiovascular risk after liver transplantation." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418005.

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46

ChacoÌn-Chaves, Ronald Alfredo. "Respiratory function after lung transplantation." Thesis, University of Newcastle upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247836.

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47

Brice, Sarah Louise, and sarahlbrice@gmail com. "Regional Immunosuppression for Corneal Transplantation." Flinders University. Medicine, 2010. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20100811.113448.

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Corneal transplantation is performed to restore vision or to relieve pain in patients with damaged or diseased corneas. However, approximately 40% of corneal allografts fail after 10 years. The most common cause of graft failure is irreversible immunological rejection, primarily mediated by CD4+ T cells, despite the topical application of glucocorticosteroids. The aim of this project was to investigate the anatomic site of antigen presentation during corneal transplantation in the rat, by using a lentiviral vector to express an anti-CD4 antibody fragment at potential sites of antigen presentation, including the donor corneal endothelium, the anterior segment of the eye and the cervical lymph nodes. Dual-gene lentiviral vectors were constructed by inserting the 2A self-processing sequence between two transgenes. This allowed expression of two transgenes within a single open reading frame. In vitro characterisation of the dual-gene vectors was performed in cell culture experiments, which showed that transgenic proteins were expressed at lower levels from dual-gene vectors compared to the expression from single-gene vectors and expression was lowest when the transgene was situated downstream of the 2A self-processing sequence. To locate the anatomic site of antigen presentation during corneal transplantation in rats, a lentiviral vector carrying an anti-CD4 antibody fragment was delivered to the corneal endothelium either immediately prior to corneal transplantation by ex vivo transduction of the donor corneas, or 5 days prior to corneal transplantation by anterior chamber injection into both the recipient and the donor rats. A separate group of recipient rats received intranodal injections of the lentiviral vector carrying an anti-CD4 antibody fragment into the cervical lymph nodes 2 days prior to corneal transplantation. Another group of rats underwent bilateral lymphadenectomy of the cervical lymph nodes 7 days prior to corneal transplantation. Corneal allografts were scored daily for opacity, inflammation and neovascularisation. Expression of the anti-CD4 antibody fragment from transduced tissues was detected using flow cytometry and polymerase chain reaction. Modest, but significant prolongation of corneal allograft survival was experienced by rats that received ex vivo transduction of the donor corneas with a lentiviral vector carrying an anti-CD4 antibody fragment immediately prior to corneal transplantation, but all grafts did eventually reject. Anterior chamber injection of the lentiviral vector carrying the anti-CD4 antibody fragment 5 days prior to corneal transplantation into both recipient and donor eyes did not prolong allograft survival. Intranodal injection of a lentiviral vector carrying an anti-CD4 antibody fragment did not prolong the survival of the corneal allografts, nor did bilateral lymphadenectomy of the cervical lymph nodes 7 days prior to corneal transplantation. Neither expression of the anti-CD4 antibody fragment in the cervical lymph nodes nor the removal of these nodes was able to prolong corneal allograft survival in rats, suggesting that T cell sensitisation could potentially occur elsewhere in the body. However, expression of the anti-CD4 antibody fragment from the donor corneal endothelium was able to prolong corneal allograft survival, suggesting that some antigen presentation might occur within the anterior segment of the eye. Based on the findings described in this thesis and those of others, I propose that antigen presentation in the rat occurs within anterior segment of the eye and within the secondary lymphoid tissues such as the cervical lymph nodes, and that inhibiting antigen presentation at one of these sites will delay graft rejection. However, to completely abolish antigen presentation during corneal transplantation in the rat, I hypothesise that antigen presentation within both the anterior segment of the eye and within the secondary lymphoid tissues must be inhibited.

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48

Polak, Wojciech Grzegorz. "Technical aspects of liver transplantation." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.

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49

Marelli, Daniel. "Cell transplantation for myocardial repair." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61231.

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It was hypothesized that skeletal muscle (SKM) satellite cells multiplied in vitro could be used to repair injured heart muscle. The purpose of this study was to test this hypothesis by auto-transplanting SKM satellite cells to a myocardial injury site. Fourteen dogs underwent explanation of the anterior tibialis muscle. Satellite cells were multiplied in vitro and their nuclei were labelled with tritiated thymidine 24 hours prior to implantation. The same dogs were then subjected to a myocardial injury by the application of a cryoprobe. The cells were suspended in serum free growth medium and implanted within the damaged muscle.
There was persistence of the implantation channels in the experimental sites when compared to the controls. Macroscopically, muscle tissue completely surrounded by scar could be seen. Masson trichrome staining showed homogeneous scar in the control site, but not in the test site where a patch of muscle fibres containing intercalated discs (characteristic of myocardial tissue) was observed. In 2 dogs, specimens were taken at 14 weeks post-implantation. Muscle tissue could not be found. Electrically stimulated skeletal muscle regenerates did not show histological evidence of cardiac transformation.
These results support the hypothesis that SKM satellite cells can form neo-myocardium within an appropriate environment. The specimens failed to demonstrate the presence of myocyte nuclei. (Abstract shortened by UMI.)

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50

Qin, Shi-Xin. "Transplantation tolerance with monoclonal antibodies." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305697.

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