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Journal articles on the topic 'Transplantatie'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 March 2023

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1

Grisar, K. "Bilateral autogenous transplantation of impacted maxillary canines." Nederlands Tijdschrift voor Tandheelkunde 126, no. 9 (September 6, 2019): 429–35. http://dx.doi.org/10.5177/ntvt.2019.09.19007.

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2

BRIES G and BOOGAERTS MA. "Alternatieve bronnen van stamcellen voor transplantatie." Tijdschrift voor Geneeskunde 54, no. 13 (January 1, 1998): 931–37. http://dx.doi.org/10.2143/tvg.54.13.5000167.

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3

. "402 Planningsbesluit Transplantatie Van Organen Gewijzigd." Zorg en Financiering 4, no. 3 (March 2005): 120–21. http://dx.doi.org/10.1007/bf03090520.

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4

Terveer, E. M. "Fecal microbiota transplantation, a novel therapy for recurrent Clostridium difficile infection." Nederlands Tijdschrift voor Tandheelkunde 123, no. 09 (September 9, 2016): 406–9. http://dx.doi.org/10.5177/ntvt.2016.09.16146.

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5

MAERTENS J, DEMUYNCK H, VERHOEF G, VANDENBERGHE P, ZACHÉE P, and BOOGAERTS MA. "Transplantatie met gezuiverde stamcellen bij patiënten met gemetastaseerde tumoren." Tijdschrift voor Geneeskunde 54, no. 5 (January 1, 1998): 332–37. http://dx.doi.org/10.2143/tvg.54.5.5000060.

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6

Nuijts, R. M. M. A. "Corneachirurgie, transplantatie en laseren bij cornea-aandoeningen en refractieafwijkingen." Bijblijven 22, no. 4 (April 2006): 160–68. http://dx.doi.org/10.1007/bf03059930.

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7

Nieuwdorp, Max. "Fecale microbiota transplantatie, meer dan een behandeling voor Clostridium difficile?" Bijblijven 36, no. 3 (June 2020): 51–58. http://dx.doi.org/10.1007/s12414-020-0117-4.

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8

DE POORTER P, VAN HEE R, YSEBAERT D, VAN DONINCK W, and KOOTSTRA G. "Het nut van machinale preservatie bij de transplantatie van "marginale" donornieren." Tijdschrift voor Geneeskunde 55, no. 1 (January 1, 1999): 39–43. http://dx.doi.org/10.2143/tvg.55.1.5000310.

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9

. "ciclosporine, transplantatie ciclosporine, kankerCiclosporine-gebruik en kanker, ciclosporinekankerincidentie na niertransplantatie, ciclosporinetransplantatie." Medisch-Farmaceutische Mededelingen 38, no. 3 (March 2000): 58–59. http://dx.doi.org/10.1007/bf03057503.

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10

Fritz, J. M. "Herstel na allogene transplantatie van de meniscus: een overzicht van de literatuur en een casusonderzoek." Stimulus 16, no. 4 (December 1997): 267–71. http://dx.doi.org/10.1007/bf03087094.

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11

Ardi, Laurencia. "Penggunaan Produk Biosimilar pada Transplantasi Ginjal." Cermin Dunia Kedokteran 48, no. 11 (November 1, 2021): 365. http://dx.doi.org/10.55175/cdk.v48i11.1559.

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<p>Transplantasi ginjal sering menimbulkan rejeksi, oleh karenanya diperlukan obat-obatan imunosupresan sebelum, saat, dan setelah transplantasi ginjal. Terapi imunosupresan pada transplantasi ginjal terdiri dari terapi induksi, pemeliharaan awal, dan pemeliharaan jangka panjang. Beberapa produk biosimilar dapat digunakan untuk terapi rejeksi pada transplantasi ginjal.</p><p> </p>Kidney transplantation often results in rejection; it is necessary to give immunosuppressant drugs before, during, and after kidney transplantation. Immunosuppressant therapy in kidney transplantation consists of induction therapy, early maintenance, and long-term maintenance. Several biosimilar products can be used for immunosuppressant in kidney transplants.<strong></strong>

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12

Matevossian, Edouard, Dionysios Kolliogianis, Stephan Kemmner, and Stefan Thorban. "Allogene heterotope Nierentransplantation." Dialyse aktuell 26, no. 07 (September 2022): 312–15. http://dx.doi.org/10.1055/a-1742-7261.

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ZUSAMMENFASSUNGZusammenfassend lässt sich klinisch evident bestätigen, dass eine allogene heterotope Nierentransplantation von Säuglings- und Neugeborenenspendern eine praktikable langfristige Option für die Behandlung von Nierenerkrankungen erwachsener normalgewichtiger Empfänger mit terminaler dialysepflichtiger Niereninsuffizienz darstellt. Unsere Daten zur Funktionalität der Transplantate im Langzeitverlauf zeigen, dass eine Nierentransplantation von solch kritischen Spendern in Transplantationszentren mit langjähriger klinischer Erfahrung in einem interdisziplinären Team eine bewährte Option ist. Allerdings bedarf es einer strengen Auswahl des Empfängers und einige Fakten sprechen nach Übersicht der zitierfähigen Fachliteratur für das erhöhte Risiko eines frühen Transplantatverlusts infolge einer Transplantat-Venen-Thrombose. En bloc entnommene und heterotop en bloc transplantierte Nieren von kleinen pädiatrischen/neonatalen Spendern haben ähnliche Überlebens- und Funktionsraten im Vergleich zu Transplantaten von größeren traditionellen erwachsenen Spendern und überlegene Ergebnisse im Vergleich zu denen von postmortalen Spendern mit erweiterten Kriterien.

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13

Rohmah, Lailatu. "Kontekstualisasi Hadis Tentang Transplantasi." Hikmah: Journal of Islamic Studies 14, no. 2 (November 25, 2018): 105. http://dx.doi.org/10.47466/hikmah.v14i2.109.

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Organ transplantation as a medical technique is a new improvement and discovery in the world of modern medicine. For example, the first successfully heart Transplantation was carried out in 1967. Until now many organs or tissues can be transplanted, including skin, cornea, bones, blood vessels, kidneys, heart, liver, lungs, and pancreas. While in the review of Islamic law, transplantation is a contemporary issue, and there are no texts in the Qur’an and Hadith that explicitly mentioning transplantation. Because of its increasing widespread of the organ transplants, it is regarded obligatory to study further in the Islamic perspective or Hadith on organ transplants. In this article, the author analyzes the Hadith relating to the transplants, then relates to the social context and various opinions of the scholars about organ transplants. Keywords: Contextualization Hadith, Transplantation Transplantasi organ sebagai teknik pengobatan merupakan kemajuan dan temuan baru dalam dunia kedokteran modern. Misalnya, Transplantasi jantung pertama kali sukses dilakukan tahun 1967. Hingga kini sudah banyak organ atau jaringan yang dapat ditransplantasikan, antara lain kulit, kornea, tulang, pembuluh darah, ginjal, jantung, hati, paru, dan pankreas. Sementara dalam tinjauan hukum Islam transplantasi ini merupakan masalah kontemporer, dan tidak ada nash al- Qur’an dan hadis yang secara eksplisit menyebutkan tentang transplantasi tersebut. Karena semakin maraknya transplantasi organ ini, maka dipandang perlu dikaji lebih jauh dalam perspektif Islam tentang transplantasi organ tersebut. Dalam artikel ini, penulis mengkaji hadis yang berkaitan dengan transplantasi, kemudian dikaitkan dengan konteks sosial serta berbagai pendapat ulama tentang transplantasi organ tubuh. Kata Kunci: Kontekstualisasi, Hadis, Transplantasi

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14

Paškonis, Marius, Laimutis Andreika, Linas Andreika, Jonas Jurgaitis, Feliksas Jankevičius, and Kęstutis Strupas. "Inksto transplantato de novo karcinomos gydymas perkutanine radiodažnine abliacija: klinikinis atvejis." Lietuvos chirurgija 14, no. 4 (December 29, 2015): 279–83. http://dx.doi.org/10.15388/lietchirur.2015.4.9205.

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Pastebėta, jog piktybinių navikų dažnis žmonėms, kuriems persodinti inkstai, yra didesnis nei bendrojoje populiacijoje. Inkstų karcinomos sudaro 4,8 % visų navikų, nustatomų recipientams, ir vos 10 % – transplantate. Transplantato navikai gali būti perduoti donoro, metastazės iš kitų recipiento organų arba de novo (naujai) vystytis po transplantacijos. De novo navikai transplantate nustatomi vidutiniškai 10 metų po transplantacijos. Mes aprašome klinikinį atvejį 45 metų vyro, kuriam 16 metų po inksto persodinimo atsitiktinai aptikta besimptomė neišplitusi 15 mm dydžio papilinė inksto karcinoma apatiniame transplantato poliuje. Ligoniui sėkmingai atlikta minimaliai invazyvi procedūra – perkutaninė radiodažninė abliacija, kuri visiškai sunaikino naviką išsaugodama transplantato funkciją. Ankstyvųjų komplikacijų nenustatyta. Praėjus vieneriems metams po procedūros vėžinės ligos atsinaujinimo ar vėlyvųjų komplikacijų požymių nėra, išlieka adekvati transplantato funkcija be hemodializės poreikio.

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15

Hölig, Kristina, and Andrea Rosner. "Transfusionsmedizinische Versorgung von Patienten nach allogener Blutstammzelltransplantation." TumorDiagnostik & Therapie 40, no. 10 (November 29, 2019): 663–71. http://dx.doi.org/10.1055/a-1031-7410.

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ZusammenfassungIm Rahmen einer allogenen Blutstammzelltransplantation kommt es häufig zu immunhämatologischen Phänomenen, die im Rahmen der Diagnostik und der supportiven Hämotherapie berücksichtigt werden müssen. Durch Diskrepanzen der AB0-Merkmale von Spender und Empfänger können verschiedene Komplikationen auftreten. Die wesentlichsten sind ein verzögertes Engraftment der Erythropoese nach major-inkompatibler Transplantation (sogenannte Pure-red-Cell-Aplasie, PRCA) und die verzögerte Hämolyse durch Aktivierung von minor-inkompatiblen Lymphozyten im Transplantat, das sogenannte Passenger-Lymphocyte-Syndrom (PLS). Durch ein gezieltes immunhämatologisches Monitoring der Patienten können diese Phänomene zeitgerecht erkannt und adäquat therapiert werden. Ein Wechsel im Bereich des Rhesusantigens D ist ebenfalls bei der Hämotherapie allogen transplantierter Patienten zu berücksichtigen, verursacht allerdings nur selten Komplikationen. Hinsichtlich der Thrombozytenversorgung sollte rechtzeitig vor Konditionierungsbeginn eine gezielte Diagnostik von Immunisierungen gegen HLA- (humane Leukozyten-Antigene) und Plättchen-spezifische Antigene erfolgen, um die Thrombozytenversorgung mit ausgewählten Spendern in der Aplasiephase zuverlässig gewährleisten zu können. Bei sehr breit und hochtitrig immunisierten Patienten kann eine Immunsuppression mit Rituximab und Immunadsorption vor Transplantation die Inkremente nach Thrombozytensubstitution verbessern und im Falle von einem HLA-Mismatch des Transplantats auch das Engraftment unterstützen.

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16

Hölig, Kristina, and Andrea Rosner. "Transfusionsmedizinische Versorgung von Patienten nach allogener Blutstammzelltransplantation." Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie 8, no. 02 (April 19, 2018): 78–86. http://dx.doi.org/10.1055/s-0043-121104.

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ZusammenfassungIm Rahmen einer allogenen Blutstammzelltransplantation kommt es häufig zu immunhämatologischen Phänomenen, die im Rahmen der Diagnostik und der supportiven Hämotherapie berücksichtigt werden müssen. Durch Diskrepanzen der AB0-Merkmale von Spender und Empfänger können verschiedene Komplikationen auftreten. Die wesentlichsten sind ein verzögertes Engraftment der Erythropoese nach majorinkompatibler Transplantation (sogenannte Pure-red-Cell-Aplasie [PRCA]) und die verzögerte Hämolyse durch Aktivierung von minorinkompatiblen Lymphozyten im Transplantat, das sogenannte Passenger-Lymphocyte-Syndrom (PLS). Durch ein gezieltes immunhämatologisches Monitoring der Patienten können diese Phänomene zeitgerecht erkannt und adäquat therapiert werden. Ein Wechsel im Bereich des Rhesusantigens D ist ebenfalls bei der Hämotherapie allogen transplantierter Patienten zu berücksichtigen, verursacht allerdings nur selten Komplikationen. Hinsichtlich der Thrombozytenversorgung sollte rechtzeitig vor Konditionierungsbeginn eine gezielte Diagnostik von Immunisierungen gegen HLA- (humane Leukozytenantigene) und plättchenspezifische Antigene erfolgen, um die Thrombozytenversorgung mit ausgewählten Spendern in der Aplasiephase zuverlässig gewährleisten zu können. Bei sehr breit und hochtitrig immunisierten Patienten kann eine Immunsuppression mit Rituximab und Immunadsorption vor Transplantation die Inkremente nach Thrombozytensubstitution verbessern und im Falle von einem HLA-Mismatch des Transplantats auch das Engraftment unterstützen.

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17

Riniatsih, Ita, Retno Hartati, Sri Redjeki, and Hadi Endrawati. "Studi Keanekaragaman Makrozoobentos Pada Habitat Lamun Hasil Transplantasi dengan Metode Ramah Lingkungan." Jurnal Kelautan Tropis 21, no. 1 (April 3, 2018): 29. http://dx.doi.org/10.14710/jkt.v21i1.2401.

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Abstract The Study of The Diversity of Makrozoobentos in Habitats Seagrass Results Transplantation with Environmentally Friendly Techniques Damage to seagrass ecosystems resulting in loss of habitat makrozoobentos.The effort to fix them with seagrass transplantation program. Transplantation of seagrass with environment friendly techniques is expected to help to recreate habitat for makrozoobentos. Research on makrozoobentos diversity in habitats seagrass transplantation results using two methods of transplantation techniques bamboo frame and bamboo tubes. The seagrass Enhalus acoroides type is transplanted. Research conducted in the waters of the Teluk Awur and Bandengan, Jepara and was conducted from August-November 2017. Research carried out with the widest swath of 4x4m with depth 85-100 cm. The number of type makrozoobnetos which is obtained during research is captured as many as 25 types look different at each sampling observations. Until the end of the observation makrozoobentos abundance ranged from 106.1-89.8 ind/m2 on the transplantation of seagrass with bamboo frames and methods of tube bamboo and seagrass pastures in both locations. Index of diversity and uniformity of makrozoobentos obtained in the category of low to moderate from each treatment.Keywords: makrozoobentos, transplantation techniques, environmentally, Enhalus acoroides Abstrak Kerusakan ekosistem padang lamunmengakibatkan hilangnya habitat makrozoobentos. Upaya untuk memperbaikinya dengan melakuka transplantasi lamun.Transplantasilamun dengan metode yang ramah lingkungan diharapkan dapat membantu untuk menciptakan kembali habitat untuk biota bentik (makrozoobentos). Penelitian tentang keanekaragaman makrozoobentospada habitat lamun hasil transplantasi menggunakan dua metode transplantasi yaitu metode frame dan tabung bambu. Lamun yang ditransplantasikan adalah jenis Enhalus acoroides. Penelitian yang dilakukan di perairan padang lamun di Teluk Awur dan Bandengan Jepara ini dilaksanakan dari Agustus–Nopember 2017. Penelitian dilakukan dengan petak seluas 4x4m dengan kedalaman 85-100cm.Jumlah jenis makrozoobnetos yang diperoleh selama penelitian adalah sebanyak 25 jenis yang tertangkap terlihat berbeda disetiap sampling pengamatan. Hingga akhir pengamatan kelimpahan makrozoobentos berkisar antara 89,8-106,1 ind/m2 pada transplantasi lamun dengan metode frame bambu dan tabung bambu serta padang lamun asli di kedua lokasi. Indeks Keanekaragaman dan keseragaman makrozoobentos yang diperoleh dalam kategori rendah hingga sedang pada ketiga perlakuan di atas.Kata Kunci: makrozoobentos, metode transplantasi, lingkungan, Enhalus acoroides

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18

Alimuddin, ,., Odang Carman, and Sri Setyo Wulandari. "Testicular cell transplantation of neon tetra Paracheirodon innesi into common carp fry." Jurnal Akuakultur Indonesia 12, no. 2 (May 12, 2015): 113. http://dx.doi.org/10.19027/jai.12.113-120.

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<p class="NoParagraphStyle" align="center"><strong>ABSTRACT</strong></p><p class="NoParagraphStyle" align="center"><strong> </strong></p><p class="NoParagraphStyle">Neon tetra <em>Paracheirodon innesi</em> is an ornamental fish that have high export value. However, production is still relatively low due to low fecundity (approximately 180 eggs/female). Technology of testicular cell transplantation of neon tetra as donor to common carp as recipient fish which have high fecundity provides a promising way to overcome problem of neon tetra production. This research was performed to determine the optimum age of common carp fry that is able to receive donor cells and allow high success of transplantation. In this research, the testes of neon tetra fish were dissociated by 0.5% trypsin solution. The testicular cells were labeled with PKH-26 fluorescent dye, and then transplanted into the peritoneal cavity of seven, ten, and 14 days post hatching common carp fry. The results showed that the survival of seven day-old transplanted fry (31.25%) was lower than that of ten day-old (37.75%) and 14 day-old transplanted fry (56.25%). Percentage of fish colonized testicular cells donor at 21 days post-transplantation on seven days old and ten days old fry were similar (80%), while on 14 day-old fry was 60%. Based on the cumulative transplantation success rate (survival and colonization rates), transplantation on 14 days old fry (33.75%) showed higher result compared to transplantation on seven days old fry (25.00%) and ten day-old fry (30.00%). It can be concluded that transplantation of neon tetra testicular cells to common carp fry have been successfully carried out, and the optimum age of common carp fry to transplantation was 14 days after hatching.</p><p class="NoParagraphStyle"> </p><p class="NoParagraphStyle">Keywords: transplantation, colonization, testicular cells, common carp, neon tetra</p><p class="NoParagraphStyle"> </p><p class="NoParagraphStyle"> </p><p class="NoParagraphStyle" align="center"><strong>ABSTRAK</strong></p><p class="NoParagraphStyle" align="center"><strong> </strong></p><p class="NoParagraphStyle">Ikan neon tetra <em>Paracheirodon innesi</em> merupakan ikan hias yang memiliki nilai ekspor yang tinggi. Namun demikian, tingkat produksinya masih relatif rendah karena fekunditas ikan neon tetra yang sedikit (sekitar 180 telur/induk). Teknologi transplantasi sel testikular ikan neon tetra (ikan donor) ke ikan mas yang memiliki fekunditas telur yang banyak dan diharapkan mampu mengatasi ketersediaan benih ikan neon tetra. Penelitian ini bertujuan untuk menentukan umur optimum benih ikan mas (calon ikan semang) yang mampu menerima sel donor dengan baik dan memiliki keberhasilan kolonisasi yang tinggi. Testis ikan neon tetra didisosiasi menggunakan larutan tripsin 0,5%. Sel testikular diwarnai dengan PKH-26, kemudian ditransplantasikan ke rongga peritoneal benih ikan mas umur tujuh, sepuluh, dan 14 hari setelah menetas. Hasil penelitian menunjukkan bahwa tingkat kelangsungan hidup ikan mas perlakuan transplantasi umur tujuh hari (31,25%) lebih rendah dibandingkan dengan perlakuan transplantasi umur sepuluh hari (37,50%) dan 14 hari (56,25%). Persentase ikan terkolonisasi sel donor pada hari ke-21 pascatransplantasi pada benih umur tujuh dan sepuluh hari adalah sama (80%), sedangkan transplantasi benih umur 14 hari sebesar 60%. Berdasarkan keberhasilan transplantasi secara kumulatif (tingkat kelangsungan hidup dan kolonisasi), transplantasi pada benih umur 14 hari (33,75%) menunjukkan hasil lebih tinggi dibandingkan dengan perlakuan transplantasi pada benih umur tujuh hari (25,00%) dan benih umur sepuluh hari (30,00%). Transplantasi sel testikular ikan neon tetra pada benih ikan mas telah berhasil dilakukan, dan umur optimum benih ikan mas adalah 14 hari setelah menetas.</p><p class="NoParagraphStyle"> </p><p class="NoParagraphStyle">Kata kunci: transplantasi, kolonisasi, sel testikular, ikan mas, ikan neon tetra</p><p> </p>

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19

Hermanto, Bambang. "The Growht of Acropora Formosa Fragment in Different Sizes Using Transplantation Method in Lembeh Strait." JURNAL ILMIAH PLATAX 3, no. 2 (February 16, 2016): 90. http://dx.doi.org/10.35800/jip.3.2.2015.13224.

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Transplantation method is an effective way for rehabilitating the degraded coral reef. Acropora formosa is one of the coral species that is used for transplantation method which is a kind of branching corals that have a rapid growth up to 8 cm/year. This study aimed to determine the effect of coral fragment size to the coral growth, survival rate and the growth rate of Acropora formosa at several locations in the Lembeh Strait. The research was conducted in February - June 2015 using concrete block transplantation method. The results showed that Acropora formosa with the initial fragment length 8 cm have the highest of survival rates (84 %), absolute growth (0,8 cm) and growth rate (0,201 cm/month). The initial fragments length of Acropora formosa can affect the coral growth in transplantation method (p <0.05). Keywords: Coral transplantation, Acropora formosa, Fragment size, North Sulawesi ABSTRAK Metode transplantasi merupakan metode yang cukup efektif untuk merehabilitasi kondisi terumbu karang yang mengalami degradasi. Salah satu jenis yang sering digunakan untuk metode transplantasi yaitu jenis Acropora formosa yang merupakan jenis karang bercabang yang memiliki pertumbuhan yang cukup cepat hingga 8 cm/tahun. Penelitian ini bertujuan untuk mengetahui pengaruh ukuran fragmen terhadap pertumbuhan karang, tingkat kelangsungan hidup serta laju pertumbuhan fragmen karang Acropora formosa pada beberapa lokasi di perairan Selat Lembeh. Penelitian dilakukan pada bulan Februari - Juni 2015 dengan menggunakan metode transplantasi lepas dasar (substrat beton). Hasil penelitian menunjukkan bahwa fragmen karang Acropora formosa dengan panjang fragmen awal 8 cm memiliki tingkat kelangsungan hidup, pertumbuhan mutlak dan laju pertumbuhan tertinggi yaitu mencapai 84% (survival rate), 0,8 cm (pertumbuhan mutlak tinggi) dan 0,201 cm/bln (laju pertumbuhan). Ukuran panjang awal fragmen Acropora formosa cukup berpengaruh terhadap pertumbuhan karang (p<0,05). Kata kunci: Transplantasi karang, Acropora formosa, ukuran fragmen, Sulawesi Utara

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20

Marti, Hans-Peter, Christina Dörje, and Erik H. Strøm. "Bedeutung und Management der Rezidive von Glomerulonephritiden im Nierentransplantat." Therapeutische Umschau 72, no. 3 (March 1, 2015): 199–206. http://dx.doi.org/10.1024/0040-5930/a000665.

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Rezidive von Glomerulonephritiden nach Nierentransplantation stellen eine wichtige Ursache des Transplantatversagens speziell im Langzeitverlauf dar. Die genaue Häufigkeit hängt einerseits vom Typ der glomerulären Grunderkrankung ab und anderseits davon, ob die Rezidive klinisch-pathologisch oder nur histologisch festgestellt werden. Der Einfluss der Rezidive auf die Funktion und das Überleben des Nierentransplantats variiert je nach der Grunderkrankung ebenfalls stark. Rezidive nach IgA-Nephropathie (IgAN) treten beispielsweise je nach Beobachtungsdauer bei über 50 % der Transplantate mit oft relativ langsamer Progredienz auf. Fokal segmentale Glomerulosklerose und membranoproliferative Glomerulonephritis haben jedoch generell eine deutlich schlechtere Prognose. Die neueren Erkenntnisse der Pathogenese einiger Glomerulopathien haben zu neuen Therapien geführt, die in Studien kleinerer Patientengruppen teilweise recht positive Resultate gezeigt haben. Neue Therapieformen wurden insbesondere für folgende Erkrankungen berichtet: Fokal segmentale Glomerulosklerose, idiopathische membranöse Nephropathie, membranoproliferative Glomerulonephritis Typ 2 (Dense Deposit Disease), IgA-Nephropathie und atypisches hämolytisch-urämisches Syndrom (aHUS). Insbesondere Rituximab oder Eculizumab stellen bei einigen dieser Pathologien interessante neuere Therapieansätze dar. Das Rezidiv der Glomerulonephritis stellt nach Abstoßung und Tod mit funktionierendem Transplantat die dritthäufigste Ursache des Transplantatversagen dar. Insgesamt aber weisen Patienten mit einer glomerulären Grunderkrankung gegenüber den Patienten mit anderen renalen Grunderkrankungen ein etwa vergleichbares Transplantat-Langzeitüberleben auf. Trotzdem gibt es einzelne davon abweichende Untersuchungen; so zeigt eine neuere Arbeit ein leicht schlechteres Langzeitüberleben der Nierentransplantate bei wegen einer Glomerulonephritis transplantierten Patienten. Wichtig ist, dass die Glomerulonephritiden als Grundleiden insgesamt gesehen keine Kontraindikation zur Transplantation, inklusive der Lebendspende einer Niere, darstellen.

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21

Mačionienė, Ernesta, and Marius Miglinas. "INKSTO TRANSPLANTATO PAŽEIDIMO BIOŽYMENYS." Medicinos teorija ir praktika 22, no. 3 (January 2, 2017): 199–202. http://dx.doi.org/10.15591/mtp.2016.030.

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Reikšminiai žodžiai: inksto transplantatas, biožymenys. Pacientams po inksto transplantacijos stebėti ir atmetimui diagnozuoti taikoma inksto transplantato biopsija, tačiau tai invazinis tyrimo metodas, esant indikacijoms, atliekamas atsižvelgiant į gana vėlyvus ir nespecifinius rodiklius – kreatinino koncentraciją kraujo serume arba proteinuriją. Ieškoma naujų neinvazinių transplantato pažeidimo žymenų, kurie leidžia anksčiau nustatyti transplantato pažeidimą ar diferencijuoti atmetimą nuo kitų transplantato funkcijos pablogėjimo priežasčių. Vieni tokių perspektyvių žymenų – chemokinai 9 ir 10, įvairios mikro RNR molekulės (miRNR-10b, miRNR-10a ir miRNR-210) bei ankstyvi, bet nespecifiniai žymenys – NGAL ir KIM-1. Tikimasi, kad šie biožymenys leis anksčiau diagnozuoti transplantato pažeidimą ir skirti atitinkamą gydymą.

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Špinarová, Lenka, Jindřich Špinar, and Jiří Vítovec. "The heart transplantation." Vnitřní lékařství 64, no. 9 (September 1, 2018): 860–66. http://dx.doi.org/10.36290/vnl.2018.118.

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Špinarová, Lenka. "Heart transplantation." Cor et Vasa 50, no. 3 (March 1, 2008): 133–38. http://dx.doi.org/10.33678/cor.2008.045.

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SIMINOFF, LAURA A., and MARY BETH MERCER. "Public Policy, Public Opinion, and Consent for Organ Donation." Cambridge Quarterly of Healthcare Ethics 10, no. 4 (September 26, 2001): 377–86. http://dx.doi.org/10.1017/s0963180101004042.

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Medical advances in transplantation techniques have driven an exponential increase in the demand for transplantable organs. Unfortunately, policy efforts to bolster the organ supply have been less than effective, failing to provide a stopgap for ever-increasing numbers of patients who await organ transplantation. The number of registrations on waiting lists exceeded 65,245 in early 1999, a 325% increase over the 20,000 that existed 11 years earlier in 1988. Regrettably, more than 4,000 patients die each year while awaiting transplantation.

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KASTALI, Mourad, Abdallah BOULGHERAIF, Lydia BEZZI, Nouara BENKACIMI, Khayreddine BENRABEH, Imene B. OUHARAOUA, and Imane MAMERI. "Post-transplant diabetes." Batna Journal of Medical Sciences (BJMS) 5, no. 1 (December 25, 2018): 14–17. http://dx.doi.org/10.48087/bjmsra.2018.5104.

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Le diabète représente une complication fréquente après la transplantation. Son incidence varie entre 2 et 50 %. Des facteurs sont associés au risque de développer un diabète chez les transplantés rénaux, on citera parmi ces facteurs : l’âge avancé du receveur, l’obésité, les antécédents familiaux de diabète, la polykystose rénale, l’infection par le virus de l’hépatite C ou par le cytomégalovirus. Le diabète post transplantation est associé à une diminution de la fonction du greffon et de la survie du patient et à une augmentation de la perte de greffon. Des mesures préventives doivent être prises avant même la transplantation. La prise en charge du diabète post transplantation est presque identique à celle du diabète de type 2.

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de Vries, Reinier J., Stephanie E. J. Cronin, Padraic Romfh, Casie A. Pendexter, Rohil Jain, Benjamin T. Wilks, Siavash Raigani, et al. "Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion." PLOS ONE 16, no. 10 (October 27, 2021): e0258833. http://dx.doi.org/10.1371/journal.pone.0258833.

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Ischemia reperfusion injury (IRI) is a critical problem in liver transplantation that can lead to life-threatening complications and substantially limit the utilization of livers for transplantation. However, because there are no early diagnostics available, fulminant injury may only become evident post-transplant. Mitochondria play a central role in IRI and are an ideal diagnostic target. During ischemia, changes in the mitochondrial redox state form the first link in the chain of events that lead to IRI. In this study we used resonance Raman spectroscopy to provide a rapid, non-invasive, and label-free diagnostic for quantification of the hepatic mitochondrial redox status. We show this diagnostic can be used to significantly distinguish transplantable versus non-transplantable ischemically injured rat livers during oxygenated machine perfusion and demonstrate spatial differences in the response of mitochondrial redox to ischemia reperfusion. This novel diagnostic may be used in the future to predict the viability of human livers for transplantation and as a tool to better understand the mechanisms of hepatic IRI.

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Kalmár Nagy, Károly, Szabolcs Horváth, Péter Szakály, László Piros, and Róbert Langer. "Role of simultaneous pancreas-kidney transplantation in the treatment of diabetes mellitus." Orvosi Hetilap 154, no. 22 (June 2013): 850–56. http://dx.doi.org/10.1556/oh.2013.29637.

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The life expectancy of patients with type 1 diabetes mellitus is inferior to that of patients with some malignancies. Simultaneous pancreas-kidney transplantation is the procedure providing the best survival results among all options of renal replacement therapy. The operative techniques and immunosuppresion have been standardized in the last decade. Although the number of transplantable organs falls behind the need, simultaneous pancreas-kidney transplantation is the method of choice for the eligible patients. The results of the two Hungarian simultaneous pancreas-kidney transplantation programs are in accordance with data published in the international literature. Orv. Hetil., 2013, 154, 850–856.

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PEARSON, RACHAEL A., CLAIRE HIPPERT, ANNA B. GRACA, and AMANDA C. BARBER. "Photoreceptor replacement therapy: Challenges presented by the diseased recipient retinal environment." Visual Neuroscience 31, no. 4-5 (June 19, 2014): 333–44. http://dx.doi.org/10.1017/s0952523814000200.

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AbstractVision loss caused by the death of photoreceptors is the leading cause of irreversible blindness in the developed world. Rapid advances in stem cell biology and techniques in cell transplantation have made photoreceptor replacement by transplantation a very plausible therapeutic strategy. These advances include the demonstration of restoration of vision following photoreceptor transplantation and the generation of transplantable populations of donor cells from stem cells. In this review, we present a brief overview of the recent progress in photoreceptor transplantation. We then consider in more detail some of the challenges presented by the degenerating retinal environment that must play host to these transplanted cells, how these may influence transplanted photoreceptor cell integration and survival, and some of the progress in developing strategies to circumnavigate these issues.

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Nugroho, Eriawan Agung, Muhamad Azwin Kamar, Ardy Santosa, Nanda Daniswara, and Sofyan Rais Addin. "Hubungan antara Total Waktu Iskemik pada Transplan Ginjal dengan Lama Perawatan di Rumah Sakit: A Single Center Report." Medica Hospitalia : Journal of Clinical Medicine 7, no. 1 (May 18, 2020): 41–45. http://dx.doi.org/10.36408/mhjcm.v7i1.426.

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Latar Belakang : Transplantasi ginjal diakui sebagai kemajuan utama pengobatan modern yang memberikan kehidupan berkualitas tinggi kepada pasien penyakit ginjal stadium akhir (End Stage Renal Disease). Waktu iskemik dingin /Cold Ischemic Time (CIT) telah ditemukan sebagai faktor risiko independen yang penting untuk delay graft function (DGF) pada transplantasi ginjal. Terdapat informasi terbaru bahwa waktu iskemik hangat /Warm Ischemic Time (WIT) yang lama dapat mengurangi kelangsungan hidup graft dalam donor hidup transplantasi ginjal. Tujuan dari penelitian ini adalah untuk mengevaluasi hubungan total ischemik time selama operasi penerima dengan lama rawat inap. Metode : Penelitian ini merupkaan studi observational-cross sectional. Data didapatkan dari catatan medis pasien yang telah menjalani transplantasi ginjal dari Januari 2014 – Desember 2018 du RS Umum dr. Kariadi semarang. Terdapat 28 pasien, 18 diantaranya adalah laki-laki dan 10 adalah wanita. Data total waktu iskemik dibandingkan dengan lamanya rawat inap. Data dianalisa dengan tes Spearman menggunakan software SPSS versi 23. Hasil : Pada studi ini menunjukkan adanya korelasi yang signifikan antara total waktu iskemik dengan lama perawatan di rumah sakit (p<0.001). Akan tetapi, umur donor tidak mempengaruhi total waktu iskemik (p=0.673), tidak signifikan (signifikan jika p<0.005). Simpulan : Adanya hubungan yang signifikan antara total waktu iskemik dengan lama perawatan rumah sakit. Namun, tidak ditemukannya hubungan yang signifikan pada usia donor dan total waktu iskemik. Kata kunci: total waktu iskemik, lama perawatan, transplantasi ginjal Background: Kidney transplantation is recognized as an advanced modern therapeutic modality, providing a better life for patients with end stage renal failure globally. Cold Ischemic Time (CIT) has been found as an important independent risk factor for delay graft function (DGF) in kidney transplantation. DGF also associated with patient’s survival post-operatively. Recent studies suggested that prolonged Warm Ischemic Time (WIT) may decrease graft’s survival in living kidney transplantation donor. This study aimed to evaluate the total ischemic time during recipient surgery and accessed its contribution for hospitalization time in kidney transplantation patients. Methods: This is a descriptive retrospective study. This study was started in 2014 until December 2018, including data from patients’ medical record whom underwent kidney transplantation in Kariadi General Hospital Semarang. Data was collected from 28 patients, including 18 male patients and 10 female patients. The author found a significant correlation between patient’s age and total ischemic time. Total ischemic time also compared with hospitalization time. Data was processed using Spearman test in SPSS software. Results: Based on Spearman test, Total ischemic time was significantly correlated with hospitalization time (p < 0.001). However, donor’s age did not affect prolonged total ischemic time with p = 0.673, which is not significant (significant if p value < 0.05). Conclusion: Total ischemic time has a significant correlation with hospitalization time. In contrary, no significant correlation between donor’s age and prolonged total ischemic time. Key Words: Total ischemic time, hospitalization time, kidney transplantation

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Chung, Yang Jo, Chul Won Choi, Christopher Slape, Terry Fry, and Peter D. Aplan. "A NUP98-HOXD13 Fusion Gene Induces a Transplantable Myelodysplastic Syndrome in Mice." Blood 110, no. 11 (November 16, 2007): 401. http://dx.doi.org/10.1182/blood.v110.11.401.401.

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Abstract The myelodysplastic syndromes (MDSs) are a group of hematologic stem cell disorders characterized by ineffective hematopoiesis and dysplasia. A large number of chromosomal aberrations including deletions, amplifications, inversions, and translocations, some of which involve the NUP98 gene, have been associated with MDS. Recently an MDS mouse model expressing a NUP98-HOXD13 (NHD13) fusion gene was developed, which faithfully recapitulates all of the key features of MDS. Although it is well-established that acute myeloid leukemia (AML) is transplantable, there is no evidence that MDS is a transplantable condition. Therefore, in order to develop evidence for MDS as a hematopoietic stem cell (HSC) disease, we attempted to transfer MDS to normal recipients through bone marrow transplantation (BMT). All the recipients transplanted with bone marrow (BM) cells from NHD13 mice with MDS showed anemia, leukopenia, lymphopenia, and neutropenia when compared to recipients of wild-type (WT) littermates. The homing efficiency of the NHD13 primitive progenitor cells (Lineage negative [Lin−], Sca-1+) was about 2 fold higher than WT, and there was no significant difference in BM cellularity between the recipients of NHD13 and WT BM, indicating that the NHD13 recipients had ineffective hematopoiesis. These phenomena were reproduced in secondary recipients using primary recipients of NHD13 BM as donor mice. In secondary transplantation assays, 3 out of 5 recipients developed acute myeloid leukemia (AML) at 16 weeks post-transplantation. Morphological features of MDS, including nuclear-cytoplasmic asynchrony, binucleate cells, hypersegmented neutrophils, and giant platelets were detected in BM and peripheral blood of NHD13 donor, primary and secondary recipients by cytospin preparations. In competitive repopulation assays, mice transplanted with equal numbers of WT and NHD13 BM cells showed a decreased percentage of NHD13 cells in the peripheral blood, but an increased percentage of NHD13 cells in the BM, again providing evidence of ineffective hematopoiesis of the NHD13 cells. The transplantation of lineage depleted cells from BM has shown that the transplantable cells for MDS reside in the Lin− population of NHD13 BM. These findings demonstrate that MDS can be transferred to healthy recipients by BMT, supporting the concept that MDS originates in a transplantable multilineage hematopoietic stem cell.

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Ruutu, Tapani, Christian Koenecke, and Grzegorz W. Basak. "Allogeneic hematopoietic stem cell transplantation and solid organ transplantation in the same patient." Cellular Therapy and Transplantation 4, no. 1-2 (2015): 14–18. http://dx.doi.org/10.18620/1866-8836-2015-4-1-2-14-18.

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Lončarić, Antun, and Tanja Ćelić. "Serumska ekspresija OPG/RANKL sustava u kroničnoj bubrežnoj bolesti i kod primatelja bubrežnog transplantata." Medicina Fluminensis 56, no. 4 (December 1, 2020): 529–36. http://dx.doi.org/10.21860/medflum2020_245230.

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Cilj: Ciljevi ove studije su istražiti ima li omjer serumskih vrijednosti RANKL/OPG bolje prognostičke vrijednosti uspoređen s razinom iPTH-a u serumu te ispitati ovise li razine OPG-a i RANKL-a u serumu o terapiji vitaminom D. Ispitanici i metode: Istraživanje je obuhvatilo 120 pacijenata iz Kliničkog bolničkog centra Rijeka, Hrvatska. Pacijenti su podijeljeni u dvije skupine; skupina pacijenata na hemodijalizi (HD) i skupina primatelja bubrežnog transplantata. Primatelji transplantata bubrega uključeni su u trenutku transplantacije te praćeni 12 mjeseci nakon transplantacije. Rezultati: Prema rezultatima ovog istraživanja, serumske razine RANKL/OPG u skupini pacijenata na hemodijalizi koji su imali iPTH > 33 pmol/l i iPTH < 11 pmol/l bile su značajno veće u odnosu na one koji su imali iPTH 11 – 33 pmol/l. Također, razine RANKL/OPG u skupini primatelja bubrežnog transplantata koji su imali iPTH > 33 pmol/l i iPTH < 11 pmol/l bile su značajno veće, u usporedbi s onima koji su imali iPTH 11 – 33 pmol/l. Pacijenti na hemodijalizi i primatelji bubrežnog transplantata na terapiji vitaminom D imali su značajno više razine OPG-a u serumu i značajno nižu razinu sRANKL-a, od ispitanika bez terapije vitaminom D. Zaključak: Rezultati ovog istraživanja ukazuju na povoljan učinak vitamina D u prevenciji gubitka koštane mase kod pacijenata na hemodijalizi i kod primatelja bubrežnog transplantata. Omjer serumske razine RANKL/OPG korelira s vrijednostima iPTH-a, ali ostaje nejasno zašto je omjer RANKL/OPG nizak u umjereno povišenim vrijednostima iPTH-a te su potrebna dodatna istraživanja kako bismo dobili odgovor na ovo pitanje.

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Schaefers, Hans J. "Lung transplantation-current status." Journal of the Japanese Association for Chest Surgery 19, no. 3 (2005): 285. http://dx.doi.org/10.2995/jacsurg.19.285.

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Dabak, Gül, and Ömer Şenbaklavacı. "History of Lung Transplantation." Turkish Thoracic Journal 17, no. 2 (June 10, 2016): 71–75. http://dx.doi.org/10.5578/ttj.17.2.014.

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Dewangan, Sangeeta. "Renal Transplantation in Children." International Journal of Trend in Scientific Research and Development Volume-3, Issue-2 (February 28, 2019): 644–49. http://dx.doi.org/10.31142/ijtsrd21432.

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Schwartz, Howard S. "Bioethical and Legal Considerations in Increasing the Supply of Transplantable Organs: From UAGA to “Baby Fae”." American Journal of Law & Medicine 10, no. 4 (1985): 397–437. http://dx.doi.org/10.1017/s0098858800009369.

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AbstractIn the last 35 years, organ transplant technology has advanced greatly. The major problem associated with organ transplantation is organ availability, and not surgery-related mortality. This article examines current organ procurement procedures and technologies, legislative repsonses to the scarcity of transplantable organs, as well as the psychological barriers to organ donation. Issues of fairness in the allocation of scarce economic and social resources, the role of religion and ethics in organ donation and transplantation decision, and the impact of the media are also considered.

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ANKENY, RACHEL A. "Recasting the Debate on Multiple Listing for Transplantation through Consideration of Both Principles and Practice." Cambridge Quarterly of Healthcare Ethics 8, no. 3 (July 1999): 330–39. http://dx.doi.org/10.1017/s0963180199803089.

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Debates continue to surround the system in the United States for allocating transplantable cadaveric organs, due in large part to the scarcity of such organs in relation to the number of individuals waiting to undergo transplantation. Candidates awaiting transplantation gain access to cadaveric organs by being placed by individual transplant programs on the national list of the Organ Procurement and Transplantation Network (OPTN), overseen by the United Network for Organ Sharing (UNOS). In recent years, the UNOS board has visited (and revisited) the issue of multiple listing, that is, allowing one candidate to be registered on the waiting lists of two or more transplant programs, and has continued to permit multiple listing.

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Jakubec, Petr, Monika Žurková, Lenka Hajdová, Aneta Křenková, and Vítězslav Kolek. "The complications after lung transplantation." Vnitřní lékařství 63, no. 11 (November 1, 2017): 848–59. http://dx.doi.org/10.36290/vnl.2017.158.

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Ozábalová, Eva, Jan Krejčí, Petr Hude, Julius Godava, Tomáš Honek, Lenka Špinarová, Petr Pavlík, Helena Bedáňová, and Petr Němec. "Heart transplantation and infection." Vnitřní lékařství 63, no. 7-8 (July 1, 2017): 535–39. http://dx.doi.org/10.36290/vnl.2017.109.

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Málek, Ivan. "Indications for heart transplantation." Cor et Vasa 50, no. 3 (March 1, 2008): 129–32. http://dx.doi.org/10.33678/cor.2008.044.

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Drismayanti, Irma, Sariatun T, Surijana Mappangara, and Muh Ruslin. "Pengaruh bone graft dan splitting osteotomy terhadap perkembangan akar gigi molar ketiga immature yang ditransplantasi The effect of bone graft and splitting osteotomy on development of the root of transplanted immature third molar." Journal of Dentomaxillofacial Science 10, no. 1 (February 28, 2011): 6. http://dx.doi.org/10.15562/jdmfs.v10i1.245.

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One of the basic requirements for succesfull transplantation is an adequate size of recipient site with sufficientalveolar support. If the transplantation is performed into a fresh extraction site, the recipient site can easily beadjusted to the transplantation. However, the situation is different in patient with premolar aplasia or early molarloss with marked atrophy of the alveolar process, need additional surgical procedures like bone autograft orsplitting osteotomy of the alveolar process. This paper discussed the effect of bone autograft and splitting osteotomyon root development of transplanted immature third molars. The conclusion is these additional surgical prosedureshad a negative effect on the pulpal and periodontal condition of transplantated immature third molars. This may berelated to revascularization disturbances of pulp due to nutrient insufficiency of the recipient site.

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Oktariana, Desi, Legiran Legiran, Phey Liana, Kemas Y. Rahadiyanto, Gita D. Prasasty, Evi Lusiana, and Nia S. Tamzil. "Transplantasi Stem Cell untuk Keganasan Hematologi." eJournal Kedokteran Indonesia 10, no. 2 (September 5, 2022): 186–93. http://dx.doi.org/10.23886/ejki.10.123.186-93.

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Insiden keganasan hematologi terus bertambah serta memiliki tingkat morbiditas dan mortalitas yang tinggi. Keganasan hematologi adalah kondisi sel-sel hematologi seperti eritrosit, leukosit, dan trombosit, tumbuh tidak terkendali dan tidak mengalami kematian sehingga mendominasi populasinya dan tidak dapat berfungsi normal. Terapi stem cell pada keganasan hematologi yang disebut juga terapi transplantasi sumsum tulang, merupakan modalitas terapi utama untuk gangguan hematologi dan keganasan yang memungkinkan pemulihan komponen seluler darah, termasuk monosit, limfosit, basofil, eosinofil, neutrofil, eritrosit, dan trombosit. Stem cell yang dapat digunakan pada keganasan hematologi adalah kombinasi hematopoietic stem cell (HSC) dan mesenchymal stem cells (MSC) untuk transplantasi sumsum tulang dan pemulihan kekebalan untuk gangguan hematologi. Penggunaan HSC dengan ko-terapi MSC dapat memfasilitasi kelangsungan hidup cangkok dari transplantasi HSC. Kata kunci: keganasan, hematologi, stem cell. Stem Cell Transplantation for Hematology Malignancy Abstract The incidence of hematological malignancies continues to increase and has a high rate of morbidity and mortality. Hematological malignancies are conditions of hematological cells such as erythrocytes, leukocytes, and platelets, growing uncontrollably and not dying so that they dominate the population and cannot work normally. Stem cell therapy in hematological malignancies, also known as bone marrow transplantation therapy, is the main therapeutic modality for hematological disorders and malignancies that supports the restoration of cellular components of blood, including monocytes, lymphocytes, basophils, eosinophils, neutrophils, erythrocytes, and platelets. Stem cells that can be used in hematological malignancies are a combination of hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) for bone marrow transplantation and immune restoration for hematological disorders. The use of HSCs with MSC co-therapy can help revive grafts from HSC transplants. Key words: malignancy, hematology, stem cell.

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Antin, Joseph H. "Reduced-Intensity Stem Cell Transplantation." Hematology 2007, no. 1 (January 1, 2007): 47–54. http://dx.doi.org/10.1182/asheducation-2007.1.47.

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Abstract The recognition that the immune system can play a major role in the control and cure of transplantable disorders led to the development of reduced-intensity allogeneic transplantation. The notion is that a compromise can be made between the intensity of conditioning and the fostering of graft-versus-host disease/ graft-versus-leukemia (GVHD/GVL), allowing the use of less intense conditioning with concomitantly less intense immediate toxicity. Reduced-intensity conditioning regimens have allowed the application of transplantation to older patients and to patients with underlying medical problems that preclude full-dose transplantation. Clearly, in some settings in which dose intensity is important, reduced-intensity regimens are less useful. However, for diseases that are either indolent, highly susceptible to GVL, or under good control before entering transplantation, this approach appears to have substantial benefits. Although the therapy appears to be valuable, concerns about delayed immune reconstitution and GVHD remain.

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Healey, Kathleen M., Steven Z. Pavletic, Jinan Al-Omaishi, M. Patricia Leuschen, Samuel J. Pirruccello, Mary L. Filipi, Charles Enke, et al. "Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation." Multiple Sclerosis Journal 10, no. 3 (June 2004): 284–89. http://dx.doi.org/10.1191/1352458504ms1022oa.

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This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and C SF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantatio n strategies for this disease.

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Kawamura, Norio, and Akinobu Taketomi. "Liver Transplantation for Locally Advanced Hepatocellular Carcinoma." Digestive Disease Interventions 04, no. 01 (March 2020): 003–12. http://dx.doi.org/10.1055/s-0040-1702996.

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AbstractSince the Milan criteria were accepted as the gold standard, liver transplantation has been widely performed as a curative treatment for early-stage hepatocellular carcinoma (HCC). The outcome of liver transplantation in early-stage HCC is excellent; however, the Milan criteria are strict, and therefore, only limited numbers of patients can benefit from liver transplantation. Many HCC patients are diagnosed at an advanced stage, which falls outside the Milan criteria, so it has been proposed over the last two decades that liver transplant surgeons should perform liver transplantation in locally advanced HCC, when presenting without recurrence. Several trials exploring the upper limits of liver transplantation have been performed, and extensive research on tumor biology has enabled the expansion of liver transplant indication for HCC. Simultaneously, locoregional therapy for advanced HCC was found to be an effective procedure when used to distinguish potentially transplantable patients. This treatment approach, known as a downstaging strategy, has been developed over the last two decades and became an essential treatment option for locally advanced HCC. In this article, the current strategies of liver transplantation for the treatment of locally advanced HCC are reviewed.

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Feldman, Eric A. "Culture, Conflict, and Cost: Perspectives on Brain Death in Japan." International Journal of Technology Assessment in Health Care 10, no. 3 (1994): 447–63. http://dx.doi.org/10.1017/s026646230000667x.

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AbstractJapanese surgeons have performed only one heart transplant in the quarter century since the procedure was developed. Possessing the requisite training and technology, transplant surgeons have been stymied by several factors that elude professional and political solution. Most critically, the lack of a brain death standard limits the availability of transplantable organs. Mistrust of the medical profession, traditional outlooks on death, and the primacy placed on consensual decision making have fueled debate about brain death and transplantation. Volatile and value laden, these issues have overwhelmed the discussion of health care resources, equal access to high-technology medical procedures, and insurance coverage for transplantation.

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Chmielnicki, Marc, Wolfram Siebert, and Axel Prokop. "Fremdmaterialfreie vordere Kreuzbandersatzplastik mit Hamstring-Transplantat nach Felmet." Zeitschrift für Orthopädie und Unfallchirurgie 156, no. 02 (April 2018): 223–25. http://dx.doi.org/10.1055/s-0044-100734.

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ZusammenfassungDie vordere Kreuzbandruptur ist eine häufige Sportverletzung. Scherbelastungen können den Gelenkknorpel nachhaltig schädigen und zu einer frühzeitigen Arthrose führen. Die ligamentäre Stabilisierung des Kniegelenkes ist daher notwendig. Die arthroskopische vordere Kreuzbandersatzplastik ist heute ein Standardverfahren in der Kniechirurgie. Häufig erfolgt die Fixierung des Transplantates mit Implantaten wie z. B. Interferenzschrauben. Das fremdmaterialfreie Verfahren in der Technik nach Felmet erlaubt eine biologische, mechanisch stabile Fixierung der Hamstring-Transplantate.

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Jiang, Fang-Xu. "Male germ cell transplantation: promise and problems." Reproduction, Fertility and Development 13, no. 8 (2001): 609. http://dx.doi.org/10.1071/rd01059.

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Male germ cell transplantation is a novel technique in which donor male stem germ cells are surgically transferred to the seminiferous tubules of a recipient testis by direct injection or via the rete testis or efferent duct. All germ cells that are destined to become stem spermatogonia are defined as male stem germ cells, including primordial germ cells from the gonadal ridges, and gonocytes and stem spermatogonia from the testis, all of which are transplantable and capable of undergoing normal spermatogenesis. Xenotransplantation of male germ cells from one species into the testis of another species, including human testicular cells in the mouse, has so far proved to be unsuccessful. However, the immunodeficient mouse testis can support rat spermatogenesis and produce apparently normal rat spermatozoa. The underlying mechanisms remain elusive. The present mini-review will focus on the importance of stem spermatogonial transplantation for testicular stem cell biology and discuss the likelihood of immune rejection after transplantation, which may limit the success of all male germ cell transplantation.

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Howard, David H. "Producing Organ Donors." Journal of Economic Perspectives 21, no. 3 (July 1, 2007): 25–36. http://dx.doi.org/10.1257/jep.21.3.25.

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Organ transplantation is one of the greatest technological achievements of modern medicine, but the ability of patients to benefit from transplantation is limited by shortages of transplantable organs. The median waiting time for patients placed on the kidney transplant waiting list is over three years. Median waiting times for hearts and livers are seven months and two years, respectively. From 1995 to 2005, the number of patients placed on the waiting list for organ transplants grew at an annualized rate of 4 percent per year. As a result of the growth in the demand for organs, many observers have questioned whether the current system is capable of providing enough transplantable organs. Transplant physicians and policymakers are seriously debating proposals to pay donors and their families and to change the legal regime governing the process of obtaining consent to donation. This paper provides an overview of the rules and practices that govern the organ procurement system and reviews proposals to increase donation rates, with a focus on deceased donors.

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Sari, Maula. "Transplantasi Organ dalam Al-Quran Perspektif Tafsir Al- Maqasidi." Substantia: Jurnal Ilmu-Ilmu Ushuluddin 22, no. 1 (May 1, 2020): 61. http://dx.doi.org/10.22373/substantia.v22i1.6758.

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Health is very pivotal for life. In the modern medicine life, one of the ways to improve health is through organ transplantation. However, the practice of organ transplants is still a matter of debate among scholars, whether it is allowed or not. This study discusses organ transplants in the Qur’an through the perspective of Maqasid interpretation (objectives of sharia). The method used is qualitative or library research with the Maqasid interpretation approach. The conclusions that can be drawn from this study are: First, a person is not allowed to give or sell their organs to others. It will be permissible only for urgent needs with some provisions: it is harmless to the donors, it is not the vital organs that affect his life, and there is no other medical efforts to cure it, except with a transplant. Second, the contribution that a Moslem can make in this organ transplantation is called hifz al-nafs (saving the soul).Abstrak: Kesehatan merupakan salah satu bagian terpenting dalam kehidupan. Islam telah menetapkan beberapa dasar pedoman bagi umatnya dalam meningkatkan dan memulihkan kesehatan. Transplantasi organ termasuk solusi salah satu yang penting dalam dunia kedokteran modern. Banyaknya manusia yang tertolong dalam hal ini, sehingga transplantasi meningkat, termasuk Indonesia. Praktik transplantasi organ hingga kini masih menjadi perdebatan diantara para ulama. Baik itu yang membolehkan, atau yang tidak membolehkan. Kajian dalam penelitian ini membahas mengenai transplantasi organ dalam al-Quran dengan menggunakan perspektif tafsir maqasidi. Metode yang digunakan ialah kualitatif atau library research dengan pendekatan tafsir maqasidi. Adapun kesimpulan yang dapat ditarik dalam penelitian ini ialah: Pertama, bahwa seseorang tidak boleh memberikan atau menjual organ kepada orang lain. Di perbolehkan jika adanya ketentuan-ketentuan mendesak secara syar’i, dan tidak adanya kemudaratan bagi pendonor. Ketentuan lainnya juga bukan merupakan organ vital yang mempengaruhi kehidupannya. Dan tidak ada upaya medis lain untuk menyembuhkannya, kecuali dengan transplantasi. Kedua, Kontribusi yang dapat dilakukan mukmin dalam transplantasi organ adalah hifz al-nafs (penyelamatan Jiwa).

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