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Journal articles on the topic 'Transsulfuration pathway cystathionine-β-synthase cystathionine-γ-lyase hydrogen sulfide'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Bearden, Shawn E., Richard S. Beard, and Jean C. Pfau. "Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 5 (2010): H1568—H1576. http://dx.doi.org/10.1152/ajpheart.00555.2010.

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Homocysteine, a cardiovascular and neurocognitive disease risk factor, is converted to hydrogen sulfide, a cardiovascular and neuronal protectant, through the transsulfuration pathway. Given the damaging effects of free homocysteine in the blood and the importance of blood homocysteine concentration as a prognosticator of disease, we tested the hypotheses that the blood itself regulates homocysteine-hydrogen sulfide metabolism through transsulfuration and that transsulfuration capacity and hydrogen sulfide availability protect the endothelium from redox stress. Here we show that the transsulfu

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Berry, Thomas, Eid Abohamza, and Ahmed A. Moustafa. "Treatment-resistant schizophrenia: focus on the transsulfuration pathway." Reviews in the Neurosciences 31, no. 2 (2020): 219–32. http://dx.doi.org/10.1515/revneuro-2019-0057.

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AbstractTreatment-resistant schizophrenia (TRS) is a severe form of schizophrenia. The severity of illness is positively related to homocysteine levels, with high homocysteine levels due to the low activity of the transsulfuration pathway, which metabolizes homocysteine in synthesizing L-cysteine. Glutathione levels are low in schizophrenia, which indicates shortages of L-cysteine and low activity of the transsulfuration pathway. Hydrogen sulfide (H2S) levels are low in schizophrenia. H2S is synthesized by cystathionine β-synthase and cystathionine γ-lyase, which are the two enzymes in the tra

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Werge, Mikkel Parsberg, Adrian McCann, Elisabeth Douglas Galsgaard, et al. "The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease." Journal of Clinical Medicine 10, no. 5 (2021): 1081. http://dx.doi.org/10.3390/jcm10051081.

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The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and approximately 25% of the global population may have NAFLD. NAFLD is associated with obesity and metabolic syndrome, but its pathophysiology is complex and only partly understood. The transsulfuration pathway (TSP) is a metabolic pathway regulating homocysteine and cysteine metabolism and is vital in controlling sulfur balance in the organism. Precise control of this pathway is critical for maintenance of optimal cellular function. The TSP is closely linked to other pathways such as the folate and methionine cycles, h

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Zakluta, A. S., V. Y. Shilova, and O. G. Zatsepina. "The Effect of the Knockout of Major Transsulfuration Genes on the Pattern of Protein Synthesis in <i>D. melanogaster</i>." Молекулярная биология 57, no. 1 (2023): 139–48. http://dx.doi.org/10.31857/s0026898423010160.

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The enzymes involved in the transsulfuration pathway and hydrogen sulfide production – cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) – play an important cytoprotective role in the functioning of the organism. Using CRISPER/Cas9 technology, we obtained Drosophila lines with deleted cbs, cse, and mst genes as well as with double deletion of cbs and cse genes. We analyzed the effect of these mutations on the pattern of protein synthesis in the salivary glands of third instar larvae and in the ovaries of mature flies. In the salivary g

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Zatsepina, Olga G., Lyubov N. Chuvakova, Ekaterina A. Nikitina, et al. "Genes Responsible for H2S Production and Metabolism Are Involved in Learning and Memory in Drosophila melanogaster." Biomolecules 12, no. 6 (2022): 751. http://dx.doi.org/10.3390/biom12060751.

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The gasotransmitter hydrogen sulfide (H2S) produced by the transsulfuration pathway (TSP) is an important biological mediator, involved in many physiological and pathological processes in multiple higher organisms, including humans. Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) enzymes play a central role in H2S production and metabolism. Here, we investigated the role of H2S in learning and memory processes by exploring several Drosophila melanogaster strains with single and double deletions of CBS and CSE developed by the CRISPR/Cas9 technique. We monitored the learning and

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Xu, Zhibin, Gamika Prathapasinghe, Nan Wu, Sun-Young Hwang, Yaw L. Siow та Karmin O. "Ischemia-reperfusion reduces cystathionine-β-synthase-mediated hydrogen sulfide generation in the kidney". American Journal of Physiology-Renal Physiology 297, № 1 (2009): F27—F35. http://dx.doi.org/10.1152/ajprenal.00096.2009.

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Cystathionine-β-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine (Hcy) in the kidney. Our recent study demonstrates that ischemia-reperfusion reduces the activity of CBS leading to Hcy accumulation in the kidney, which in turn contributes to renal injury. CBS is also capable of catalyzing the reaction of cysteine with Hcy to produce hydrogen sulfide (H2S), a gaseous molecule that plays an important role in many physiological and pathological processes. The aim of the present study was to examine the effect of ischemia-reperfusio

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O, Karmin, and Yaw L. Siow. "Metabolic Imbalance of Homocysteine and Hydrogen Sulfide in Kidney Disease." Current Medicinal Chemistry 25, no. 3 (2018): 367–77. http://dx.doi.org/10.2174/0929867324666170509145240.

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Homocysteine (Hcy) and hydrogen sulfide (H2S) are important molecules produced during the metabolism of sulfur-containing amino acids. Hcy metabolism is central to the supply of methyl groups that are essential for biological function. Hcy can be either regenerated to methionine or metabolized to cysteine, a precursor for glutathione synthesis. Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway. These two enzymes are also responsible for H2S generation through desulfuration reactions. H2S, at p

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Hwang, Sun-Young, Lindsei K. Sarna, Yaw L. Siow та Karmin O. "High-fat diet stimulates hepatic cystathionine β-synthase and cystathionine γ-lyase expression". Canadian Journal of Physiology and Pharmacology 91, № 11 (2013): 913–19. http://dx.doi.org/10.1139/cjpp-2013-0106.

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Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) catalyze homocysteine (Hcy) metabolism via the trans-sulfuration pathway. They are also responsible for hydrogen sulfide (H2S) production via desulfuration reactions. The liver contributes significantly to the regulation of Hcy and H2S homeostasis, which might participate in many physiological and pathological processes. The aim of this study was to investigate the effect of a high-fat diet (HFD) on hepatic CBS and CSE expression and its impact on Hcy and H2S metabolism. Mice (C57BL/6) fed a HFD (60% kcal fat) for 5 weeks developed

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Yadav, Pramod K., Victor Vitvitsky, Hanseong Kim, Andrew White, Uhn-Soo Cho та Ruma Banerjee. "S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase–dependent hydrogen sulfide synthesis". Journal of Biological Chemistry 294, № 28 (2019): 11011–22. http://dx.doi.org/10.1074/jbc.ra119.009047.

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Hydrogen sulfide (H2S) is a gaseous signaling molecule, which modulates a wide range of mammalian physiological processes. Cystathionine γ-lyase (CSE) catalyzes H2S synthesis and is a potential target for modulating H2S levels under pathophysiological conditions. CSE is inhibited by propargylglycine (PPG), a widely used mechanism-based inhibitor. In this study, we report that inhibition of H2S synthesis from cysteine, but not the canonical cystathionine cleavage reaction catalyzed by CSE in vitro, is sensitive to preincubation of the enzyme with PPG. In contrast, the efficacy of S-3-carboxprop

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Kolluru, Gopi K., Xinggui Shen, and Christopher G. Kevil. "Reactive Sulfur Species." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 4 (2020): 874–84. http://dx.doi.org/10.1161/atvbaha.120.314084.

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Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator of critical biological processes. However, the physiological significance of hydrogen sulfide metabolites such as persulfides, polysulfides, and other reactive sulfur species (RSS) has only recently been appreciated. Emerging evidence suggests that these RSS molecules may have similar or divergent regulatory roles compared with hydrogen sulfide in various biological activities. However, the chemical nature of persulfides and polysulfides is complex and remains poorly understood within cardiovascular and oth

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González-García, Pilar, Agustín Hidalgo-Gutiérrez, Cristina Mascaraque, et al. "Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism." Human Molecular Genetics 29, no. 19 (2020): 3296–311. http://dx.doi.org/10.1093/hmg/ddaa214.

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Abstract Abnormalities of one carbon, glutathione and sulfide metabolisms have recently emerged as novel pathomechanisms in diseases with mitochondrial dysfunction. However, the mechanisms underlying these abnormalities are not clear. Also, we recently showed that sulfide oxidation is impaired in Coenzyme Q10 (CoQ10) deficiency. This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in

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Mitidieri, Emma, Annalisa Pecoraro, Erika Esposito та ін. "β3 Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide". Antioxidants 11, № 8 (2022): 1480. http://dx.doi.org/10.3390/antiox11081480.

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It is now well established that the urothelium does not act as a passive barrier but contributes to bladder homeostasis by releasing several signaling molecules in response to physiological and chemical stimuli. Here, we investigated the potential contribution of the hydrogen sulfide (H2S) pathway in regulating human urothelium function in β3 adrenoceptor-mediated relaxation. The relaxant effect of BRL 37344 (0.1–300 µM), a selective β3 adrenoceptor agonist, was evaluated in isolated human bladder strips in the presence or absence of the urothelium. The relaxant effect of BRL 37344 was signifi

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Fernandes, Dalila G. F., João Nunes, Catarina S. Tomé та ін. "Human Cystathionine γ-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H2S". Antioxidants 10, № 9 (2021): 1391. http://dx.doi.org/10.3390/antiox10091391.

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The ‘gasotransmitters’ hydrogen sulfide (H2S), nitric oxide (NO), and carbon monoxide (CO) act as second messengers in human physiology, mediating signal transduction via interaction with or chemical modification of protein targets, thereby regulating processes such as neurotransmission, blood flow, immunomodulation, or energy metabolism. Due to their broad reactivity and potential toxicity, the biosynthesis and breakdown of H2S, NO, and CO are tightly regulated. Growing evidence highlights the active role of gasotransmitters in their mutual cross-regulation. In human physiology, the transsulf

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Olson, Kenneth R., Michael J. Healy, Zhaohong Qin, et al. "Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 2 (2008): R669—R680. http://dx.doi.org/10.1152/ajpregu.00807.2007.

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O2 chemoreceptors elicit cardiorespiratory reflexes in all vertebrates, but consensus on O2-sensing signal transduction mechanism(s) is lacking. We recently proposed that hydrogen sulfide (H2S) metabolism is involved in O2 sensing in vascular smooth muscle. Here, we examined the possibility that H2S is an O2 sensor in trout chemoreceptors where the first pair of gills is a primary site of aquatic O2 sensing and the homolog of the mammalian carotid body. Intrabuccal injection of H2S in unanesthetized trout produced a dose-dependent bradycardia and increased ventilatory frequency and amplitude s

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Madden, Jane A., Susan B. Ahlf, Mark W. Dantuma, Kenneth R. Olson, and David L. Roerig. "Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung." Journal of Applied Physiology 112, no. 3 (2012): 411–18. http://dx.doi.org/10.1152/japplphysiol.01049.2011.

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The effects of hydrogen sulfide (H2S) and acute hypoxia are similar in isolated pulmonary arteries from various species. However, the involvement of H2S in hypoxic pulmonary vasoconstriction (HPV) has not been studied in the intact lung. The present study used an intact, isolated, perfused rat lung preparation to examine whether adding compounds essential to H2S synthesis or to its inhibition would result in a corresponding increase or decrease in the magnitude of HPV. Western blots performed in lung tissue identified the presence of the H2S-synthesizing enzymes, cystathionine γ-lyase (CSE) an

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Agné, Alisa M., Jan-Peter Baldin, Audra R. Benjamin та ін. "Hydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, № 7 (2015): R636—R649. http://dx.doi.org/10.1152/ajpregu.00489.2014.

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In pulmonary epithelia, β-adrenergic agonists regulate the membrane abundance of the epithelial sodium channel (ENaC) and, thereby, control the rate of transepithelial electrolyte absorption. This is a crucial regulatory mechanism for lung liquid clearance at birth and thereafter. This study investigated the influence of the gaseous signaling molecule hydrogen sulfide (H2S) on β-adrenergic agonist-regulated pulmonary sodium and liquid absorption. Application of the H2S-liberating molecule Na2S (50 μM) to the alveolar compartment of rat lungs in situ decreased baseline liquid absorption and abr

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Kundu, Sourav, Sathnur B. Pushpakumar, Aaron Tyagi, Denise Coley, and Utpal Sen. "Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9." American Journal of Physiology-Endocrinology and Metabolism 304, no. 12 (2013): E1365—E1378. http://dx.doi.org/10.1152/ajpendo.00604.2012.

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Matrix metalloproteinase-9 (MMP-9) causes adverse remodeling, whereas hydrogen sulfide (H2S) rescues organs in vascular diseases. The involvement of MMP-9 and H2S in diabetic renovascular remodeling is, however, not well characterized. We determined whether MMP-9 regulates H2S generation and whether H2S modulates connexin through N-methyl-d-aspartate receptor (NMDA-R)-mediated pathway in the diabetic kidney. Wild-type (WT, C57BL/6J), diabetic (Akita, C57BL/6J- Ins2 Akita), MMP-9−/− (M9KO), double knockout (DKO) of Akita/MMP-9−/− mice and in vitro cell culture were used in our study. Hyperglyce

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Zhao, Shuang, Céline Deslarzes-Dubuis, Severine Urfer, Martine Lambelet, Sébastien Déglise, and Florent Allagnat. "Cystathionine Gamma Lyase Is Regulated by Flow and Controls Smooth Muscle Migration in Human Saphenous Vein." Antioxidants 12, no. 9 (2023): 1731. http://dx.doi.org/10.3390/antiox12091731.

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The saphenous vein is the conduit of choice for bypass grafting. Unfortunately, the hemodynamic stress associated with the arterial environment of the bypass vein graft leads to the development of intimal hyperplasia (IH), an excessive cellular growth and collagen deposition that results in restenosis and secondary graft occlusion. Hydrogen sulfide (H2S) is a ubiquitous redox-modifying gasotransmitter that inhibits IH. H2S is produced via the reverse trans-sulfuration pathway by three enzymes: cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase

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Kitada, Munehiro, Yoshio Ogura, Itaru Monno, Jing Xu, and Daisuke Koya. "Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress." Biomedicines 9, no. 2 (2021): 130. http://dx.doi.org/10.3390/biomedicines9020130.

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Enhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health in organisms from yeast to rodents. The effect of MetR on lifespan extension and metabolic health is mediated partially through a reduction in oxidative stress. Methionine metabolism is involved in the supply of methyl donors such as S-adenosyl-methionine (SAM), glutathione synthesis and polyamine metabolism. SAM, a methionine metabolite, activates mec

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Nalli, Ancy D., Senthilkumar Rajagopal, Sunila Mahavadi, John R. Grider, and Karnam S. Murthy. "Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells." American Journal of Physiology-Cell Physiology 308, no. 6 (2015): C485—C495. http://dx.doi.org/10.1152/ajpcell.00280.2014.

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Inhibitory neurotransmitters, chiefly nitric oxide and vasoactive intestinal peptide, increase cyclic nucleotide levels and inhibit muscle contraction via inhibition of myosin light chain (MLC) kinase and activation of MLC phosphatase (MLCP). H2S produced as an endogenous signaling molecule synthesized mainly from l-cysteine via cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS) regulates muscle contraction. The aim of this study was to analyze the expression of CSE and H2S function in the regulation of MLCP activity, 20-kDa regulatory light chain of myosin II (MLC20) phosphorylati

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Liao, Ribin, Liwei Xue, Zhanrong Qiang, Cheng Zhang, and Ying Liu. "Release of endogenous hydrogen sulfide in enteric nerve cells suppresses intestinal motility during severe acute pancreatitis." Acta Biochimica et Biophysica Sinica 52, no. 1 (2019): 64–71. http://dx.doi.org/10.1093/abbs/gmz139.

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Abstract Previous studies have shown that during severe acute pancreatitis (SAP) attacks, hydrogen sulfide (H2S) is released in the colon. However, the roles played by H2S in regulating enteric nerves remain unclear. In this study, we examined the association between SAP-induced H2S release and loss of intestinal motility, and also explored the relevant mechanism in enteric nerve cells. A rat SAP model was constructed and enteric nerve cells were prepared. Intestinal mobility was evaluated by measuring the number of bowel movements at indicated time points and by performing intestinal propulsi

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Ascenção, Kelly, Nahzli Dilek, Karim Zuhra, Katalin Módis, Toshiro Sato, and Csaba Szabo. "Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids." Antioxidants 11, no. 9 (2022): 1823. http://dx.doi.org/10.3390/antiox11091823.

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Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells. Prior studies have demonstrated that isogenic organoids harboring mutations in the tumor suppressor genes APC, SMAD4 and TP53, as well as the oncogene KRAS, assumed more proliferative and invasive properties in vitro and in vivo. A separate body of studies implicates the role of various hydrogen sulfide (H2S)-producing enzymes in the pathogenesis of colon cancer. The curren

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Khan, Nazeer Hussain, Di Wang, Wenkang Wang, et al. "Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression." Molecules 27, no. 13 (2022): 4049. http://dx.doi.org/10.3390/molecules27134049.

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Hydrogen sulfide (H2S), a gaseous signaling molecule, is associated with the development of various malignancies via modulating various cellular signaling cascades. Published research has established the fact that inhibition of endogenous H2S production or exposure of H2S donors is an effective approach against cancer progression. However, the effect of pharmacological inhibition of endogenous H2S-producing enzymes (cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MPST)) on the growth of breast cancer (BC) remains unknown. In the present

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Berenyiova, Andrea, Martina Cebova, Basak Gunes Aydemir, Samuel Golas, Miroslava Majzunova, and Sona Cacanyiova. "Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H2S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization." International Journal of Molecular Sciences 23, no. 16 (2022): 9215. http://dx.doi.org/10.3390/ijms23169215.

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Increased fructose consumption induces metabolic-syndrome-like pathologies and modulates vasoactivity and the participation of nitric oxide (NO) and hydrogen sulfide (H2S). We investigated whether a slow-releasing H2S donor, GYY-4137, could exert beneficial activity in these conditions. We examined the effect of eight weeks of fructose intake on the blood pressure, biometric parameters, vasoactive responses, and NO and H2S pathways in fructose-fed spontaneously hypertensive rats with or without three weeks of GYY-4137 i.p. application. GYY-4137 reduced triacylglycerol levels and blood pressure

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Wang, Wenfu, Qiyu Bo, Jian Du, et al. "Endogenous H2S sensitizes PAR4-induced bladder pain." American Journal of Physiology-Renal Physiology 314, no. 6 (2018): F1077—F1086. http://dx.doi.org/10.1152/ajprenal.00526.2017.

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Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome. Hydrogen sulfide (H2S) generated by cystathionine β-synthase (CBS) or cystathionine γ-lyase (CSE) facilitates bladder hypersensitivity. We assessed involvement of the H2S pathway in protease-activated receptor 4 (PAR4)-induced bladder pain. A bladder pain model was induced by intravesical instillation of PAR4-activating peptide in mice. The role of H2S in this model was evaluated by intraperitoneal preadministration of d,l-propargylglycine (PAG), aminooxyacetic acid (AOAA), or S-adenosylmethionine or the pre

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DU, Jian-tong, Wei LI, Jin-yan YANG, Chao-shu TANG, Qi LI, and Hong-fang JIN. "Hydrogen sulfide is endogenously generated in rat skeletal muscle and exerts a protective effect against oxidative stress." Chinese Medical Journal 126, no. 5 (2013): 930–36. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20122485.

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Background Skeletal muscle has recently been recognized as an endocrine organ that can express, synthesize and secrete a variety of bioactive molecules which exert significant regulatory effects. Hydrogen sulfide (H2S) is endogenously produced in mammalian tissues and participates in a number of physiological and pathophysiological processes. We aimed to verify whether H2S could be endogenously generated and released by rat skeletal muscle, and determine the biological effects of H2S in rat skeletal muscle. Methods The study was divided into two parts: detection of endogenous H2S generation an

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Bush, Leah, Anthonia Okolie, Jenaye Robinson, et al. "Neuroprotective Actions of Cannabinoids in the Bovine Isolated Retina: Role of Hydrogen Sulfide." Pharmaceuticals 18, no. 1 (2025): 117. https://doi.org/10.3390/ph18010117.

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Both hydrogen sulfide and endocannabinoids can protect the neural retina from toxic insults under in vitro and in vivo conditions. Purpose: The aim of the present study was two-fold: (a) to examine the neuroprotective action of cannabinoids [methanandamide and 2-arachidonyl glycerol (2-AG)] against hydrogen peroxide (H2O2)-induced oxidative damage in the isolated bovine retina and (b) to evaluate the role of endogenously biosynthesized hydrogen sulfide (H2S) in the inhibitory actions of cannabinoids on the oxidative stress in the bovine retina. Methods: Isolated neural retinas from cows were e

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Chen, Qinghai, Shiliang Yu, Kuo Zhang, et al. "Exogenous H2S Inhibits Autophagy in Unilateral Ureteral Obstruction Mouse Renal Tubule Cells by Regulating the ROS-AMPK Signaling Pathway." Cellular Physiology and Biochemistry 49, no. 6 (2018): 2200–2213. http://dx.doi.org/10.1159/000493824.

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Background/Aims: The induction of excessive autophagy by increased levels of oxidative stress is one of the main mechanisms underlying unilateral ureteral obstruction (UUO)-induced vascular endothelial cell dysfunction. Hydrogen sulfide (H2S) has been shown to have an anti-oxidative effect, but its mode of action on excessive autophagy in vascular endothelial cells is unclear. Methods: Surgery was used to induce UUO in male C57BL/6 mice as an in vivo model. Human renal epithelial cells (HK-2) were treated with H2O2 as an in vitro model. NaHS was used as an exogenous H2S donor. Transmission ele

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Nakano, Shintaro, Isao Ishii, Noriyuki Akahoshi, et al. "Abstract 17695: Transsulfuration Pathway is Essential for Fasting-Induced Cardioprotection Against Ischemic/Reperfusion Injury." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a17695.

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<Background>: Hydrogen sulfide (H 2 S), a gaseous mediator that is endogenously produced by two transsulfuration enzymes, cystathionine β-synthase (CBS) and cystathionine gamma-lyase (CTH), is known to act against myocardial ischemia/reperfusion (I/R) injury. However, the roles of the transsulfuration that is also essential for cysteine/glutathione biosynthesis remain to be clarified. We investigated the role of transsulfuration pathway in myocardial I/R injury and fasting-induced cardioprotection using mice lacking CBS (CBS -/- ) or CTH (CTH -/- ). <Methods and results>: Ad libitu

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Nechyporuk, V. M., N. V. Zaichko та М. М. Korda. "Вплив тиреоїдних гормонів на процеси реметилування та транссульфування сірковмісних амінокислот в органах щурів". Medical and Clinical Chemistry, № 1 (28 квітня 2017). http://dx.doi.org/10.11603/mcch.2410-681x.2017.v0.i1.7689.

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Introduction. Sulfur-containing amino acids affect the vital processes of cells and methylation processes support the redox potential and integrity of cellular systems, incapacitate toxicants and free radicals. Disorders of sulfur-containing amino acids metabolism is associated with different pathologies, including Alzheimer's disease, malignant tumors, neural tube defects, kidneys diseases. The increase of sulfur-containing amino acid homocysteine in the blood is a serious risk factor of cardiovascular diseases such as atherosclerosis, hypertension, venous thrombosis. Regulation of sulfur-con

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Libiad, Marouane, Naoya Sakamoto, Eric Fearon, and Ruma Banerjee. "Hydrogen sulfide homeostasis and signaling in normal and neoplastic intestinal cells." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.773.4.

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Hydrogen sulfide (H2S) is an important gas signaling molecule with effects on multiple physiological processes including neuromodulation, inflammation and cardiac function. Maintaining healthy levels of H2S in mammalian cells requires tight control between its biosynthesis and catabolism. The biogenesis of H2S involves two enzymes from the transsulfuration (cystathionine β‐synthase (CBS) and γ‐cystathionase (CSE)) and cysteine catabolic (mercaptopyruvate sulfurtransferase) pathways. The sulfide oxidation pathway requires the concerted action of the mitochondrial enzymes: sulfide quinone reduct

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Sharew, Betemariam, Suzie Kim, Jacob Enders, Nazmin Bithi, and Christopher Hine. "Abstract 9410: Cardiovascular Disease Associated Metabolites TMA and TMAO Bind to Cystathionine Gamma-Lyase and Repress Its Enzymatic Production of Hydrogen Sulfide." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.9410.

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While the causative factors of smoking and hypertension leading to cardiovascular disease (CVD) are well understood, those involved with diet-induced CVD are not. One metabolite regulated by diet that is involved with cardio-protection and vasodilation is the gasotransmitter hydrogen sulfide (H 2 S). However, the molecular inhibition of H 2 S-generating enzymes via CVD-inducing diets is not fully understood, nor is it known if this is the causative event leading to CVD. Enzymatic H 2 S production in mammalian tissues and cells is primarily via the transsulfuration enzymes cystathionine β-synth

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Nechyporuk, V. M., та M. M. Korda. "Метаболізм цистеїну при експериментальному гіпер- та гіпотиреозі в щурів". Medical and Clinical Chemistry, № 4 (11 січня 2018). http://dx.doi.org/10.11603/mcch.2410-681x.2017.v0.i4.8433.

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Introduction. Sulfur-containing amino acids provide vital processes of the cell, maintain the integrity of the redox potential, neutralize free radicals and toxic agents that provide remethylation cycle and transsulfuration processes. It is known that cysteine is formed in cells from homocysteine, and can be used, depending on the needs of the cell for the synthesis of protein, glutathione, in a desulfuration pathway with the formation of hydrogen sulfide (H2S). Regulation of the metabolism of sulfur-containing amino acids is carried out at different levels, including the endocrine system, in

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Billiar, Timothy R., Giuseppe Cirino, David Fulton, Roberto Motterlini, Andreas Papapetropoulos, and Csaba Szabo. "Hydrogen sulphide synthesis in GtoPdb v.2023.1." IUPHAR/BPS Guide to Pharmacology CITE 2023, no. 1 (2023). http://dx.doi.org/10.2218/gtopdb/f279/2023.1.

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Hydrogen sulfide is a gasotransmitter, with similarities to nitric oxide and carbon monoxide. Although the enzymes indicated below have multiple enzymatic activities, the focus here is the generation of hydrogen sulphide (H2S) and the enzymatic characteristics are described accordingly. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are pyridoxal phosphate (PLP)-dependent enzymes. 3-mercaptopyruvate sulfurtransferase (3-MPST) functions to generate H2S; only CAT is PLP-dependent, while 3-MPST is not. Thus, this third pathway is sometimes referred to as PLP-independent. CBS and C

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Řimnáčová, Hedvika, Jiří Moravec, Miriama Štiavnická, et al. "Evidence of endogenously produced hydrogen sulfide (H2S) and persulfidation in male reproduction." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-15360-x.

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AbstractPersulfidation contributes to a group of redox post-translational modifications (PTMs), which arise exclusively on the sulfhydryl group of cysteine as a result of hydrogen sulfide (H2S) action. Redox-active molecules, including H2S, contribute to sperm development; therefore, redox PTMs represent an extremely important signalling pathway in sperm life. In this path, persulfidation prevents protein damage caused by irreversible cysteine hyperoxidation and thus maintains this signalling pathway. In our study, we detected both H2S and its production by all H2S-releasing enzymes (cystathio

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36

DeRatt, Barbara, Maria Ralat, and Jess Gregory. "Characterization of Cystathionine Beta‐Synthase and Cystathionine Gamma‐Lyase in the Production of Hydrogen Sulfide Biomarkers, Lanthionine and Homolanthionine, in a HepG2 Cell Culture Model." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1171.5.

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Hydrogen sulfide (H2S) is an essential gasotransmitter with the ability induce vasodilation and exert other cardioprotective effects in‐vivo, yet accurate quantification of H2S is difficult and often erroneous. Proposed biomarkers, lanthionine and homolanthionine, are produced concurrently with H2S by the pyridoxal 5′‐phosphate (PLP) dependent‐transsulfuration enzymes, cystathionine beta‐synthase (CBS) and cystathionine gamma‐lyase (CSE). This study sought to determine the contribution of CBS and CSE in the production of H2S biomarkers in a HepG2 cell culture model. Isotopic tracers, [U‐13C5]

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Billiar, Timothy R., Giuseppe Cirino, David Fulton, Roberto Motterlini, Andreas Papapetropoulos, and Csaba Szabo. "Hydrogen sulphide synthesis (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database." IUPHAR/BPS Guide to Pharmacology CITE 2019, no. 4 (2019). http://dx.doi.org/10.2218/gtopdb/f279/2019.4.

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Hydrogen sulfide is a gasotransmitter, with similarities to nitric oxide and carbon monoxide. Although the enzymes indicated below have multiple enzymatic activities, the focus here is the generation of hydrogen sulphide (H2S) and the enzymatic characteristics are described accordingly. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are pyridoxal phosphate (PLP)-dependent enzymes. 3-mercaptopyruvate sulfurtransferase (3-MPST) functions to generate H2S; only CAT is PLP-dependent, while 3-MPST is not. Thus, this third pathway is sometimes referred to as PLP-independent. CBS and C

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Billiar, Timothy R., Giuseppe Cirino, David Fulton, Roberto Motterlini, Andreas Papapetropoulos, and Csaba Szabo. "Hydrogen sulphide synthesis (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database." September 17, 2019. https://doi.org/10.2218/gtopdb/f279/2019.4.

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Abstract:

Hydrogen sulfide is a gasotransmitter, with similarities to nitric oxide and carbon monoxide. Although the enzymes indicated below have multiple enzymatic activities, the focus here is the generation of hydrogen sulphide (H2S) and the enzymatic characteristics are described accordingly. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are pyridoxal phosphate (PLP)-dependent enzymes. 3-mercaptopyruvate sulfurtransferase (3-MPST) functions to generate H2S; only CAT is PLP-dependent, while 3-MPST is not. Thus, this third pathway is sometimes referred to as PLP-independent. CBS and C

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Melnik, A. V., та N. V. Zaichko. "Гендерні особливості впливу гіпергомоцистеїнемії на метаболізм сірковмісних амінокислот та гідроген сульфіду в печінці". Medical and Clinical Chemistry, № 1 (28 квітня 2017). http://dx.doi.org/10.11603/mcch.2410-681x.2017.v0.i1.7352.

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Introduction. Sulfur amino acid disorders are recognized as metabolic risk factors for cardiovascular pathology. However, the question of the involvement of sulfur amino acids in the formation of the gender-defined pathology of cardiovascular system remains unclear.The aim of the study – research the impact of thiolactone hyperhomocysteinemia (HHC) on blood levels of sulfur-containing metabolites and enzymes activity in metabolism of homocysteine, cysteine and hydrogen sulfide in the liver of rats of both sexes.Methods of the research. Experiments were conducted on 40 white laboratory rats of

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Carmen, Fernández-Rodríguez a. 1. Iker Oyenarte a. 1. Carolina Conter b. 1. Irene González-Recio a. Reyes Núñez-Franco a. Claudia Gil-Pitarch a. Iban Quintana c. Gonzalo Jiménez-Osés a. Paola Dominici b. Maria Luz Martinez-Chantar a. Alessandra Astegno b. ⇑. Luis Alfonso Martínez-Cruz a. ⇑. "Structural insight into the unique conformation of cystathionine b-synthase from Toxoplasma gondii." May 15, 2021. https://doi.org/10.5281/zenodo.5533917.

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<strong>Abstract</strong> Cysteine plays a major role in the redox homeostasis and antioxidative defense mechanisms of many parasites of the phylum Apicomplexa. Of relevance to human health is Toxoplasma gondii, the causative agent of toxoplasmosis. A major route of cysteine biosynthesis in this parasite is the reverse transsulfuration pathway involving two key enzymes cystathionine b-synthase (CBS) and cystathionine c-lyase (CGL). CBS from T. gondii (TgCBS) catalyzes the pyridoxal-5´ -phosphate-dependent condensation of homocysteine with either serine or O-acetylserine to produce cystat

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Aydinoglu, Fatma, Tugba Toyran, and Nuran Ogulener. "Age- and Urothelium-related Changes in Hydrogen Sulfide-induced Responses in Mouse Bladder." Journal of Physiological Investigation, December 13, 2024. https://doi.org/10.4103/ejpi.ejpi-d-24-00078.

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Abstract The alterations in bladder function are associated with aging. Hydrogen sulfide (H2S) is a gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to regulate bladder smooth muscle tone. The effects of age and urothelium on the L-cysteine/H2S-induced relaxant responses were investigated in young (3–4 months) and aged (23–24 months) mice. The relaxant responses to endogenous H2S (L-cysteine) augmented in denuded urothelium bladder tissue in both age groups. However, the relaxant responses to exogenous H2S (sodium hydrogen sulfide: 1 μM - 3 mM) did not chang

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Paul, Bindu Diana, and Solomon H. Snyder. "Role of neuronal signaling effector hydrogen sulfide (H₂S) and sulfhydration in Huntington's disease." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1271.6.

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Hydrogen sulfide (H2S) has joined the ranks of the gasotransmitters, nitric oxide and carbon monoxide as a signaling molecule that modulates a wide spectrum of physiological processes. H2S signals via sulfhydration, wherein it mediates the conversion of −SH groups of reactive cysteine residues on target proteins to −SSH or persulfide groups. H2S is synthesized by cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS) and 3‐mercaptopyruvate sulfurtransferase of the reverse transsulfuration pathway. Aberrant H2S metabolism is involved in the progressive neurodegeneration seen in Hunt

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Tyagi, Suresh C., Sathnur Pushpakumar, Utpal Sen, et al. "The role of the circadian clock system in mitochondrial trans-sulfuration pathway and tissue remodeling." Canadian Journal of Physiology and Pharmacology, November 18, 2023. http://dx.doi.org/10.1139/cjpp-2023-0186.

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Hydrogen sulfide (H2S) is a product of epigenetics that involves trans-sulfuration pathway for clearance of homocysteine (Hcy), thereby mitigating skeletal muscle’s pathological remodeling. Although master circadian clock regulator that is known as brain and muscle aryl hydrocarbon receptor nuclear translocator like protein 1 (i.e., BMAL1) is associated with S-adenosylhomocysteine hydrolase and Hcy metabolism but how trans-sulfuration is influenced by circadian clock remains unexplored. We hypothesize that alterations in functioning of circadian clock during sleep/wake cycle affect skeletal mu

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Nunes, Sofia C., Cristiano Ramos, Inês Santos, et al. "Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming." Frontiers in Cell and Developmental Biology 9 (August 11, 2021). http://dx.doi.org/10.3389/fcell.2021.722412.

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Among gynecologic malignancies, ovarian cancer is the third most prevalent and the most common cause of death, especially due to diagnosis at an advanced stage together with resistance to therapy. As a solid tumor grows, cancer cells in the microenvironment are exposed to regions of hypoxia, a selective pressure prompting tumor progression and chemoresistance. We have previously shown that cysteine contributes to the adaptation to this hypoxic microenvironment, but the mechanisms by which cysteine protects ovarian cancer cells from hypoxia-induced death are still to be unveiled. Herein, we hyp

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Ma, Ming‐Chieh, Ho‐Shiang Huang, and Yih‐Sharng Chen. "Hypoxic Preconditioning Protects Rat Hearts Against Ischemia/Reperfusion Injury via H₂S/TRPA1 Pathway." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.lb648.

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Hypoxic preconditioning (HPC) protects rat hearts against ischemia/reperfusion (IR) injury. The Ca2+‐permeable transient receptor potential ankyrin 1 (TRPA1) is present in cardiac tissue and plays an important on blood pressure regulation. However, the role of TRPA1 in HPC‐mediated cardioprotection remains unknown. TRPA1 can be activated by a novel gasotransmitter hydrogen sulfide (H2S), which is synthesized endogenously by cystathionine β‐synthase (CBS) and cystathionine γ‐lyase (CSE). Here we examined whether HPC protects the myocardium against IR via the H2S/TRPA1 pathway. Compared to heart

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Yang, Bobo, Changsheng Yin, Yu Zhang, et al. "Differential effects of subchronic acrylonitrile exposure on hydrogen sulfide levels in rat blood, brain, and liver." Toxicology Research, April 5, 2022. http://dx.doi.org/10.1093/toxres/tfac011.

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Abstract Background Hydrogen sulfide (H2S), as the third gasotransmitter participates in both cellular physiological and pathological processes, including chemical-induced injuries. We recently reported acute acrylonitrile (AN) treatment inhibited endogenous H2S biosynthesis pathway in rat and astrocyte models. However, there is still no evidence to address the correlation between endogenous H2S and sub-chronic AN exposure. Objectives This study aims to explore the modulatory effects of prolonged AN exposure on endogenous H2S levels and its biosynthetic enzymes in rat blood, brain and liver. M

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Tyagi, Suresh, Suresh Tyagi, Sathnur Sathnur, et al. "Role of the Circadian Clock System in Trans-sulfuration Pathway and Tissue Remodeling." Physiology 38, S1 (2023). http://dx.doi.org/10.1152/physiol.2023.38.s1.5732949.

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Previous studies from our laboratory revealed that the gaseous molecule; hydrogen sulfide (H2S), a metabolic product of epigenetics which involves trans-sulfuration pathway for ensuring the metabolism and clearance of homocysteine (Hcy) from the body, helped mitigate the skeletal muscle’s pathological remodeling. Although the master circadian clock regulator that is known as the b rain and m uscle a ryl hydrocarbon receptor nuclear translocator l ike protein 1 (i.e., BMAL1) is intimately associated with S-adenosylhomocysteine hydrolase (SAHH) and Hcy metabolism but how trans-sulfuration pathwa

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