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Dissertations / Theses on the topic 'Treated patients'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Attard, Nikolai J. "Implant prosthodontic management of medically treated hypothyroid patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58784.pdf.

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2

Laurila, J. (Jouko). "Surgically treated acute acalculous cholecystitis in critically ill patients." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514280989.

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Abstract Acute acalculous cholecystitis (AAC) is an insidious and increasingly recognized complication of critical illness, whose pathogenesis is poorly understood and clinical picture obscure. Diagnosis is difficult and there is no consensus on treatment. The medical records of all ICU patients who had undergone open cholecystectomy due to AAC during the years 2000–2001 and 2003–2004 were examined for clinical and organ failure data. The indication for open cholecystectomy was a suspicion of AAC based on clinical signs and symptoms of sepsis or deteriorating multiple organ dysfunction withou

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3

Ng, Wai-man. "Quality of life of nasopharyngeal carcinoma patients treated with nasopharyngectomy." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972081.

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4

Hou, Huie-ming. "Long-term study of sleep apnoea patients treated with MAD /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31596332.

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5

Lidegran, Marika. "Advanced radiological imaging in patients treated with extracorporeal membrane oxygenation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-933-5/.

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6

Gee, G. D. "An assessment of patients treated with implant retained mandibular overdentures /." Title page, summary and contents only, 1995. http://web4.library.adelaide.edu.au/theses/09DM/09dmg297.pdf.

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7

Chahine, Carol Judith. "Extraction socket healing in pediatric patients treated with intravenous pamidronate." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106270.

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Background: Bisphosphonate use in adult patients has been linked to osteonecrosis of the jaw (ONJ). This complication has not been systematically assessed in a pediatric population receiving bisphosphonates. Objective: To assess the occurrence rate of bisphosphonate-related osteonecrosis of the jaw (BRONJ) following dental extractions in young patients receiving cyclical pamidronate.Methods: 278 patients with a median age of 14.7 years received cyclical pamidronate therapy for treatment of osteogenesis imperfecta and other bone metabolic diseases. The total annual pamidronate dose was 9 mg/kg

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8

Yan, Xiangsheng. "Dose distribution studies of rectal cancer patients treated with brachytherapy." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19239.

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We studied 42 rectal cancer brachytherapy patients with shielding included in the treatment, but without shielding included in the treatment planning and dose distribution calculations. To study the dose distribution in shielded cases, we first extracted relevant information from the PLATO BPS system and reconstructed the PLATO treatment plans with negligible errors. Based on this, we then implemented and validated the dose-superposition algorithm and applied this algorithm to all patients, finding that although the dose t

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9

Ng, Wai-man, and 吳偉民. "Quality of life of nasopharyngeal carcinoma patients treated with nasopharyngectomy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972081.

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10

胡慧明 and Huie-ming Hou. "Long-term study of sleep apnoea patients treated with MAD." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45012222.

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11

Pankiv, I. V. "Vitamin B12 levels in metformin-treated type 2 diabetes patients." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18338.

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12

Osmančević, Amra. "Vitamin D status in psoriasis patients treated with UVB therapy /." Göteborg : Dept. of Dermatology and Venereology, Sahlgrenska University Hospital, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, 2009. http://hdl.handle.net/2077/19041.

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13

Olsson, Cecilia. "Sexuality in patients treated for hematologic malignancies - Problems and need for support from patients’ and nurses’ perspectives." Doctoral thesis, Karlstads universitet, Institutionen för hälsovetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-31827.

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Aim: The overall aim of this thesis was to describe and explore how sexuality, body image and HRQoL were affected in patients treated for hematologic malignancies, and their need for support. A further aim was to describe nurses’ conceptions of dialogues about sexuality. Methods: Ten nurses in cancer care (I) and twelve patients were interviewed (II). Data were analysed according to phenomenography (I-II). Data were also collected from patients (≥45 years) included consecutively: at baseline (n=32), one month (n=25; III-IV) and six months (n=20; IV) after treatment. Three instruments were used

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14

Samad, Bassem Abdel. "Risk assessment in patients with acute myocardial infarction treated with thrombolysis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3616-1/.

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15

Patterson, Joanne Margaret. "Swallowing in head and neck cancer patients treated by (chemo) radiotherapy." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545765.

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16

Rafi, Abdolnasser. "Molecular and immunological studies on #fully treated' long term leprosy patients." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283434.

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17

Redzuan, Adyani Md. "Sodium-dietary intake, awareness and clinical outcomes in treated hypertensive patients." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4418/.

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18

Heyman, Patrick. "Hemodynamic parameters of patients with treated hypertension and coronary artery disease." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000701.

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19

Byrne, Anthony Luke. "Chronic Respiratory Disease among Successfully Treated Tuberculosis Patients of Lima, Peru." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18687.

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As a respiratory physician, I have a keen interest in understanding the contribution that tuberculosis makes to chronic respiratory disease in tuberculosis endemic countries. This provided the impetus for my research. First, I performed a systematic review of the literature asking; “Among subjects from the general population, what is the association between a history of pulmonary tuberculosis and the presence of (1) structural lung disease (chronic obstructive lung disease or bronchiectasis) and (2) reactive lung disease (asthma)?” I performed a systematic review of the literature and found th

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20

Francisco, Machado Rosa Mariela. "Patients diagnosed with Ectodermal Dysplasia and hypodontia treated with dental implants." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20476.

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Ectodermal Dysplasia (ED) is an inherent disorder which affects ectodermal tissues, including teeth. Hypodontia is the absence of teeth and it is one of classical features of ED. Patients diagnosed with ED may have signs and symptoms that can impact on speech, appearance, diet and psychosocial aspects. Many dental treatments are available to rehabilitate ED patients presenting with hypodontia, and one of these treatment is a fixed dental prosthesis (FDP) supported by implants. A multidisciplinary team is recommended to diagnose, plan and treat these patients. The aim of this study was to inves

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21

Bonato, M. "A PILOT STUDY OF BRISK WALKING IN SEDENTARY CART-TREATED PATIENTS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/258148.

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Antiretroviral treatments (ART) have dramatically reduced HIV infection mortality, transforming HIV infection into a chronic disease requiring life-long treatment. Sadly, treatment is associated with a number of metabolic, cardiovascular, osteoarticular, renal and central nervous system toxicities. Moreover, Chronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. As a result, long-term treated patients may present with increased risk of cardiovascular and cerebrovascular disease, lypodystrophy, early diabetes, kidney failure, osteop

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22

Profant, Judith. "Fatigue and sleep complaints in women treated for breast cancer /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3129934.

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23

Gälman, Daniel. "Simulations and Measurements of radiation doses from patients treated with I-131." Thesis, Umeå universitet, Radiofysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147098.

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The aim of this work is to introduce a couple of new exposure scenariosof interest when personnel, family members and general public are externally irradiated from patients treated with Iodine-131. A series of modied ORNL matematical phantoms were used in Monte-Carlo simulations in PENELOPE-2011 to determine dose rates to: a cab driver where thepatient sits in the back seat at opposite side, a newborn child held by an adult patient, a doctor giving treatment to a patient while leaning over the hospital bed and collective effective dose to bus passengers if the patient travels home by bus. The

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24

Pettersson, Anna. "Diet and Gastrointestinal Symptoms in Patients with Prostate Cancer Treated with Radiotherapy." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215410.

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Objective The main objective of this thesis was to explore the effects of diet on gastrointestinal symptoms in prostate cancer patients treated with local curative radiotherapy, by evaluating dietary intake prior to treatment (Study I), the psychometric properties of a new questionnaire on patient-reported gastrointestinal side effects (Study II), and the effect of a dietary intervention on acute and long-term gastrointestinal symptoms up to 2 years after radiotherapy completion (Study III-IV). Methods A total of 130 men with localized prostate cancer referred to dose-escalated radiotherapy (E

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25

Reid, Katherine Jane. "The experience of patients diagnosed and treated for head and neck cancer." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4333/.

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Head and neck cancer (H&NC) and its possible treatment options are diverse and multifaceted. This thesis demonstrates these complexities and describes three studies that have used different methodological approaches to include, rather than overlook these aspects. The first established which aspects of patients’ experiences are overlooked if health care professionals rely upon health related quality of life questionnaires to represent the experience of patients. The second identified that the multi-disciplinary team (MDT) working with the patients use humane judgement, not technical expertise,

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26

Coleman, Craig I., Jan Beyer-Westendorf, Thomas J. Bunz, Charles E. Mahan, and Alex C. Spyropoulos. "Postthrombotic Syndrome in Patients Treated With Rivaroxaban or Warfarin for Venous Thromboembolism." Sage, 2018. https://tud.qucosa.de/id/qucosa%3A35470.

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Postthrombotic syndrome (PTS) is a frequent complication of venous thromboembolism (VTE). Using MarketScan claims data from January 2012 to June 2015, we identified adults with a primary diagnosis code for VTE during a hospitalization/emergency department visit, ≥6 months of insurance coverage prior to the index event and newly started on rivaroxaban or warfarin within 30 days of the index VTE. Patients with <4-month follow-up postindex event or a claim for any anticoagulant during 6-month baseline period were excluded. Differences in baseline characteristics between rivaroxaban and warfarin u

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27

Фадєєва, Ганна Анатоліївна, Анна Анатольевна Фадеева, Hanna Anatoliivna Fadieieva, and N. S. Mazlan. "Clinical features of asthma course in obese patients treated by inhaled steroids." Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/15982.

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28

Gaerig, Vanesag, Roxana Lang, and Marcella Honkonen. "Post-Stroke Outcomes in Atrial Fibrillation Patients Treated with Various Oral Anticoagulants." The University of Arizona, 2015. http://hdl.handle.net/10150/614122.

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Class of 2015 Abstract<br>Objectives: Warfarin has historically been the anticoagulant used for the primary prevention of stroke in atrial fibrillation (AF), however three target specific oral anticoagulants, dabigatran, rivaroxaban, and apixaban, have recently been approved for use in this setting. Current literature lacks a comparison of these four drugs in relation to post-stroke outcomes, and this study aims to compare their performance in a natural setting. Methods: This retrospective cohort study identified stroke patients admitted to an academic medical center between January 2013 and

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29

Babicheva, Rosalie. "Radiation doses to family members of patients treated with Iodine-131 therapy." Master's thesis, School of Medical Radiation Sciences, Faculty of Health Sciences, 2001. http://hdl.handle.net/2123/5318.

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Thesis (M. App. Sc.)--University of Sydney, 2001.<br>Title from title screen (viewed Aug. 11, 2009) Includes tables. Submitted in fulfilment of the requirements for the degree of Master of Applied Science to the Faculty of Health Sciences. Includes bibliographical references. Also available in print form.

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Babicheva, Rosalie. "Radiation doses to family members of patients treated with Iodine-131 therapy." Connect to full text, 2001. http://hdl.handle.net/2123/5318.

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Thesis (M. App. Sc.)--University of Sydney, 2001.<br>Title from title screen (viewed Aug. 11, 2009) Includes tables. Submitted in fulfilment of the requirements for the degree of Master of Applied Science to the Faculty of Health Sciences. Includes bibliographical references. Also available in print form.

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31

Sundfors, Anu-Johanna. "Efficacy of trastuzumab-emtansine in breast cancer patients prior treated with pertuzumab." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78031.

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Background:T-DM1 is preferred treatment option as2ndline treatmentinpatients with metastatic HER2-positive breast cancer after progression in trastuzumab-based 1stline treatment. When T-DM1 became the preferred treatment strategy as2ndline therapy,the1stline treatment did not include pertuzumabwhich is currently standard of care. Therefore, there is lack ofknowledge aboutT-DM1 response in patients who received prior pertuzumab. Aim:To study the efficacyof T-DM1 inpatients prior treated with pertuzumab as a 1stline treatment compared to patients without prior pertuzumab use. Patients and method

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32

Telatin, Valentina. "Immunological restoration in chronic HCV-infected patients treated with different antiviral therapies." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3423262.

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SUMMARY OF THE STUDY The World Health Organization (WHO) estimates that approximately 3% of the global population is chronically infected with Hepatitis C Virus (HCV) and that approximately 3-4 million new cases of hepatitis C occur each year worldwide. While African countries have the highest prevalence of HCV infection (up to 26%) in the world, however, HCV infection represents a global health challenge from which no country, rich or poor, is spared. The acute phase of HCV infection is asymptomatic in the majority of infected individuals (75-80%), and except few cases of acute hepatitis C

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33

Valpione, Sara. "Biomarkers of prognosis and toxicity for metastatic melanoma patients treated with ipilimumab." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426202.

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Background Metastatic melanoma has a dismal prognosis, as a consequence of its intrinsic aggressiveness and the lack of effective treatment options: in fact, until recently, systemic therapies were numbered. Ipilimumab is a fully humanized monoclonal anti-Cytotoxic T-Lymphocyte Antigen 4 antibody that demonstrated a significant improvement of metastatic melanoma patient survival, however toxicity may be severe and life threatening. Clinicians lack reliable prognostic factors for prognosis and toxicity and this makes treatment decisions difficult. Methods An observational prospective study w

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34

Steckler, Josephine. "Do elderly clients in an acute care hospital perceive they are treated with dignity and respect." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28799.

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The purpose of this study was to investigate whether elderly clients in an acute care setting perceived themselves as being treated with dignity and respect, and whether clients with a higher socioeconomic status are more likely than clients with a lower socioeconomic status to be treated with dignity and respect. Sixty-two elderly clients who had been in hospital at least five days, were alert and oriented during their hospitalization, and could speak English were selected for the study. Using a convenience sampling technique, the clients were selected from medical and surgical units of two

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35

Gilbert, Alexandra Jane. "Optimising individual treatment regimes and patient outcomes through the use of patient-reported toxicity assessments in patients treated with pelvic radiotherapy." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13268/.

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The primary objectives of this thesis are to develop a systematic method for patients to self-report pelvic radiotherapy adverse events (AE) using electronically collected patient reported outcomes (PROs) in clinical practice and to evaluate patient-reported toxicity in association with radiotherapy dosimetric data and clinical factors. Before testing the research objectives in two observational studies, important practical and methodological issues were addressed. Analysis from systematic and literature reviews, content analysis of three validated PRO systems and interviews with health profes

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36

Atzeni, Fabiola. "Antibody profiles in patients treated with tumor necrosis factor-alpha antagonists: new findings." Doctoral thesis, Universitat Autònoma de Barcelona, 2005. http://hdl.handle.net/10803/3771.

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It has been reported that patients with rheumatoid arthritis (RA), Crohn's disease (CD) and spondyloarthritis (SpA) treated with selective tumor necrosis factor-alpha (TNF-?) inhibitors develop autoantibodies such as antinuclear antibodies (ANA) and anti-double stranded DNA (anti-dsDNA) antibodies. TNF-? is a pro-inflammatory cytokine that is produced by multiple cell types, including blood monocytes, macrophages, mast cells and endothelial cells, and plays multiple complex functional roles within the immune system, including the stimulation of inflammation, cytotoxicity, the regulation cell a

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37

Marcusson, Agneta. "Adult patients with treated complete cleft lip and palate : methodological and clinical studies /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med666s.pdf.

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38

Brewis, Melanie J. "Imaging right ventricular function to predict outcome in patients treated for pulmonary hypertension." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7888/.

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Pulmonary arterial hypertension (PAH) is a rare but devastating disorder of the pulmonary vasculature characterised pathologically by progressive intimal obliteration and vascular remodelling leading to increased pulmonary vascular resistance (PVR) and elevation in pulmonary arterial pressure (PAP), and clinically by functional impairment from breathlessness and ultimately death from right ventricular failure. Whilst the initial insult occurs in the pulmonary circulation, it is increasing recognised that survival relates to the ability of the right ventricle (RV) to adapt to this increased aft

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39

Chen, Wen-Hwei. "Factors associated with the clinical outcome and nephrotoxicity in patients treated with gentamicin." Scholarly Commons, 1986. https://scholarlycommons.pacific.edu/uop_etds/2130.

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40

Suwa, Taro. "Corticolimbic balance shift of regional glucose metabolism in depressed patients treated with ECT." Kyoto University, 2014. http://hdl.handle.net/2433/189637.

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41

Stoodley, Paul. "Echocardiographic measurement of cardiac function in breast cancer patients treated with anthracycline chemotherapy." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10526.

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Introduction Anthracyclines are the cornerstone of breast cancer chemotherapy, however anthracyclines can be cardiotoxic. Left ventricular (LV) ejection fraction (LVEF) is the key echocardiographic measurement for monitoring cardiotoxicity, although LVEF has limitations. Myocardial strain imaging is new technology that may improve the measurement of cardiac function. The aim of this research was to study strain imaging for potentially earlier detection of dysfunction than LVEF, in breast cancer patients treated with anthracyclines. Method Anthracycline naïve breast cancer patients were prospe

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42

McCarthy, Claire Louise. "Peripheral blood cytokine profiles of multiple sclerosis patients & the immune response of multiple sclerosis patients treated with alemtuzumab." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609204.

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43

Andersson-Roswall, Lena. "Longitudinal cognitive changes in medically and surgically treated patients with drug resistant partial epilepsy /." Göteborg : Epilepsy Research Group, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 2010. http://hdl.handle.net/2077/21931.

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44

Peterzén, Bengt. "Management of patients treated with left ventricular assist devices : A clinical and experimental study." Doctoral thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5151.

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This thesis describes the management of patients treated with mechanical circulatory support devices for short- or long-term use. Twenty-four patients suffering from postcardiotomy heart failure were treated with a minimally invasive axial flow pump. The device was effective in unloading the failing left ventricle and in maintaining an adequate systemic circulation. The principles of perioperative monitoring, and pharmacological therapy are outlined. The pump was also used as an alternative to the heart-lung machine in conjunction with coronary artery bypass surgery. Together with a short-acti

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45

Pearson, Ian Russell. "Markers of risk in patients with acute coronary syndrome treated by percutaneous coronary intervention." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/13563/.

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Background - The clinical diagnosis and categorisation of Acute Coronary Syndrome (ACS) has changed repeatedly over the last decade as have routine treatment strategies. Hypothesis - that adverse clinical events following PCI, may be predicted from the identification of markers of risk at the time of PCI. Methods - Informed consent was obtained from 968 patients fulfilling detailed inclusion and exclusion criteria surrounding a diagnosis of ACS requiring PCI. Standard medical ACS care was provided. PCI operators, techniques, methods and any decision to treat followed usual practice. Data colle

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Peterzén, Bengt. "Management of patients treated with left ventricular assist devices : a clinical and experimental study /." Linköping : Univ, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5151.

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Datta, Shreelata. "A study to investigate the immune response in ovarian cancer patients treated with chemotherapy." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/57030.

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Women with ovarian cancer usually present with advanced stage disease and, although sensitive to chemotherapy initially, the majority will relapse following first line treatment. Resistance to chemotherapy contributes to poor prognosis in ovarian cancer. A potential strategy to prolong the response to treatment and reduce chemotherapy resistance is immune based therapies. These therapies are likely to be most effective when disease is minimal or subclinical, such as at completion of first line chemotherapy, but depend on the ability to mobilize a sufficient immune response. Currently, little i

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48

Hammar, Clausen Adrian. "Follow-up of Patients Treated with Sclerosing Therapy and/or Surgery for Achilles Tendinopathy." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72993.

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Introduction: Achilles tendinopathy can be a chronic disabling condition. Sclerosing injections under ultrasonographic guidance is one method to treat Achilles tendinopathy. Initially good results have later been questioned. Surgery is another treatment option that has been questioned because of varying reported success rate. Aim: We aimed to assess patient- reported outcome in patients suffering from Achilles tendinopathy, treated with sclerosing injections and/or surgery during a 6 ½ year- period. Method: After review of patient records, the Self-reported foot and ankle score (SEFAS) togethe

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Mortimer, Ann M. "The neuropsychology of chronic severe schizophrenic patients treated with clozapine versus treatment as usual." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29435.

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Introduction: The cognitive effects of antipsychotic drugs represent a potential exploratory tool with which to investigate theoretical models of schizophrenia. According to the `levels of explanation' model, the manipulation of cognition of drugs, reflecting prior changes in brain physiology, should result in symptomatic change. Clozapine is superior to other antipsychotic drugs in the treatment of the symptoms of schizophrenia, but there was little support for the proposition that this was because of superior improvements in cognition. This study aimed to investigate this question in severel

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50

Filho, Pedro Aurio Maia. "Genotoxicity and mutagenicity in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors." Universidade Federal do CearÃ, 2017. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=19044.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Chronic myelogenous leukemia (CML) is a myeloproliferative disease of hematopoietic stem cells, characterized by the presence of the Philadelphia (Ph) chromosome, originating from a reciprocal translocation between the long arms of chromosomes 9 and 22, forming the gene BCR-ABL, which encodes a BCR-ABL oncoprotein with constitutive tyrosine kinase activity. The clinical course of CML is often divided into three phases: chronic, accelerated, and blast. The treatment of choice for the chronic phase is the first-generation tyrosine

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