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Journal articles on the topic 'Treatment for regenerating hair'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Abadie, M. S. Al, N. Abed, and M. Mahfoudh. "Stem Cell therapy for Hair Loss." Medical & Clinical Research 10, no. 03 (2025): 01–04. https://doi.org/10.33140/mcr.10.03.06.

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Stem cell research has made significant strides since its inception, with applications expanding into regenerative medicine and therapeutic treatments for various conditions, including hair loss. The discovery of hematopoietic stem cells (HSCs) in the 1960s and the advent of induced pluripotent stem cells (iPSCs) in 2006 have propelled the field into new frontiers. Stem cell-based therapies for hair loss focus on regenerating hair follicles, with sources ranging from adipose-derived stem cells (ADSCs) to hair follicle mesenchymal stem cells. These approaches leverage the unique properties of s

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Goode, Christopher T., John P. Carey, Albert F. Fuchs, and Edwin W. Rubel. "Recovery of the Vestibulocolic Reflex After Aminoglycoside Ototoxicity in Domestic Chickens." Journal of Neurophysiology 81, no. 3 (1999): 1025–35. http://dx.doi.org/10.1152/jn.1999.81.3.1025.

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Recovery of the vestibulocolic reflex after aminoglycoside ototoxicity in domestic chickens. Avian auditory and vestibular hair cells regenerate after damage by ototoxic drugs, but until recently there was little evidence that regenerated vestibular hair cells function normally. In an earlier study we showed that the vestibuloocular reflex (VOR) is eliminated with aminoglycoside antibiotic treatment and recovers as hair cells regenerate. The VOR, which stabilizes the eye in the head, is an open-loop system that is thought to depend largely on regularly firing afferents. Recovery of the VOR is

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Rizwan, Mohd. "Significant Hair Regeneration in Androgenetic Alopecia observed with Unani Treatment." International Journal of Science and Research (IJSR) 13, no. 5 (2024): 84–87. http://dx.doi.org/10.21275/sr24429110056.

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El Khatib, Sami, Dalal Hammoudi Halat, Sanaa Khaled, Ahmed Malki, and Bassam Alameddine. "Novel Compounds for Hair Repair: Chemical Characterization and In Vitro Analysis of Thiol Cross-Linking Agents." Pharmaceuticals 18, no. 5 (2025): 632. https://doi.org/10.3390/ph18050632.

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Introduction: Hair damage from chemical treatments, mechanical stress, and environmental factors can lead to significant degradation in hair quality, necessitating effective solutions for restoration. The aim of this study was to develop and evaluate novel compounds for repairing hair damage through the chemical regeneration of disulfide bridges. Materials and Methods: Three novel thiol-reactive cross-linking agents (APA, STA, SAA) were synthesized and characterized. Their efficacy in repairing hair damage was evaluated through in vitro tensile strength tests on human hair fibers, comparing tr

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Owczarczyk-Saczonek, Agnieszka, Magdalena Krajewska-Włodarczyk, Anna Kruszewska, et al. "Therapeutic Potential of Stem Cells in Follicle Regeneration." Stem Cells International 2018 (August 5, 2018): 1–16. http://dx.doi.org/10.1155/2018/1049641.

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Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate

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Ryu, Jihye. "Application and Prospect of Stem Cells in the Treatment of Alopecia." Academic Journal of Science and Technology 3, no. 1 (2022): 110–12. http://dx.doi.org/10.54097/ajst.v3i1.1969.

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This article introduces the common types of hair loss and the common types of hair loss treatments on the market, such as topical finasteride topical or oral, minoxidil, fractional laser, hair transplantation, etc. And then I introduced the common types of stem cells and described the application of stem cells in the treatment of hair loss. I focused on the extraction methods of ADSCs and the advantages of them. For example, ADSCs have antioxidant effects, promote HF and the formation of peripheral blood vessels, and play a role in regeneration and other effects. Finally, I describe the prospe

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Wang, Sen, Yu Li, Ying-Chang Ji, Chang-Min Lin, Cheng Man, and Xiao-Xuan Zheng. "The most efficient follicular regenerating unit and the smallest follicular regenerating unit: Potential treatments for hair loss." Medical Hypotheses 73, no. 6 (2009): 1035–37. http://dx.doi.org/10.1016/j.mehy.2009.05.022.

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Amini, Farahnaz, Jing Ju Teh, Chung Keat Tan, Eugenie Sin Sing Tan, and Edmond Siah Chye Ng. "A Pilot Randomized Controlled Trial (RCT) Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia." Life 15, no. 3 (2025): 500. https://doi.org/10.3390/life15030500.

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Background/Objectives: Hair loss affects self-esteem, confidence, and psychological well-being. Exosomes, as molecular carriers of growth factors and active compounds, offer a promising treatment. This study evaluates the efficacy of an exosome formulation containing extracts from two known hair-regenerating plants, Ecklonia cava and Thuja orientalis (ECPE), for male pattern alopecia. Methods: A randomized controlled trial included 20 male participants with Norwood grade 2–3 androgenetic alopecia who were randomly assigned into two groups, placebo (0.9% sodium chloride) and ECPE, administered

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Xiao, Shune, Yurong Deng, Xiaojin Mo, et al. "Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice." Stem Cells International 2020 (June 13, 2020): 1–11. http://dx.doi.org/10.1155/2020/9054514.

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Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines. Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth. Extracellular matr

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Stepanenko, R. L., Т. O. Lytynska, S. V. Ivanov, T. S. Konovalova та A. O. Humen. "Modern рerspectives on еtiopathogenesis of аlopecia аreata and рromising treatment аpproaches (Review)". Ukrainian Journal of Dermatology, Venerology, Cosmetology, № 1 (28 березня 2025): 42–47. https://doi.org/10.30978/ujdvk2025-1-42.

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Objective — to analyze current literature data on the relationship between the body’s immune system and hair follicles in the context of the etiopathogenesis of alopecia areata and to identify promising therapeutic approaches for this dermatosis. Materials and methods. A review of current scientific literature was conducted on the interaction between the body’s immune system and hair follicles. Emphasis was placed on the role of immune cells (T-cells, macrophages, dendritic cells) and their signaling pathways (interleukins, tumor necrosis factor, interferons) in maintaining homeostasis and con

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Mu, Xinyu. "Research Progress on the Application of Stem Cells in Hair Regeneration." Highlights in Science, Engineering and Technology 123 (December 24, 2024): 658–65. https://doi.org/10.54097/pzw62505.

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Hair follicle stem cells (HFSCs) exhibit significant potential in hair regeneration research due to their self-renewal and multi-directional differentiation abilities. Hair loss is a common dermatological issue, and current treatment methods have limited efficacy; however, the investigation of HFSCs offers new avenues for developing novel therapies. HFSCs are relatively easy to isolate and culture from hair follicles, making them ideal candidates for laboratory and clinical applications. In addition to their role in hair regeneration, HFSCs contribute to the regeneration of skin, bone, cardiov

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Tang, Xin, Cuixiang Cao, Yunxiao Liang та ін. "Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway". Stem Cells International 2023 (27 вересня 2023): 1–20. http://dx.doi.org/10.1155/2023/5548112.

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The most prevalent type of alopecia is androgenetic alopecia (AGA), which has a high prevalence but no effective treatment. Elevated dihydrotestosterone (DHT) level in the balding area was usually thought to be critical in the pathophysiology of AGA. The canonical Wnt/β-catenin signaling pathway plays a key role in promoting hair follicle development and sustaining the hair follicle cycle. Adipose-derived stem cell exosomes (ADSC-Exos) are widely used in the field of regenerative medicine due to the advantages of being cell free and immune privileged. Still, few studies have reported the thera

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Pawlik, Wiktoria, Agnieszka Nowotarska, Gustaw Błaszczyński, Paweł Nojek, Mariusz Zimonczyk, and Monika Zawół. "Hair loss therapies: a review and comparison of traditional and modern treatment methods." Journal of Education, Health and Sport 75 (November 25, 2024): 56191. http://dx.doi.org/10.12775/jehs.2024.75.56191.

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Introduction and objective. Hair loss is a common health issue that significantly impacts the quality of life and well-being of millions of people worldwide. Effective treatments remain a challenge for dermatologists due to the complex mechanisms behind hair loss and the diverse range of affected patients. The objective of this study is to compare the effectiveness of traditional and modern methods of treating hair loss. Brief description of the state of knowledge. Microneedling is a minimally invasive treatment that stimulates collagen production and the release of growth factors, which in tu

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Venuto, Alexandra, and Timothy Erickson. "Evaluating the Death and Recovery of Lateral Line Hair Cells Following Repeated Neomycin Treatments." Life 11, no. 11 (2021): 1180. http://dx.doi.org/10.3390/life11111180.

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Acute chemical ablation of lateral line hair cells is an important tool to understand lateral line-mediated behaviors in free-swimming fish larvae and adults. However, lateral line-mediated behaviors have not been described in fish larvae prior to swim bladder inflation, possibly because single doses of ototoxin do not effectively silence lateral line function at early developmental stages. To determine whether ototoxins can disrupt lateral line hair cells during early development, we repeatedly exposed zebrafish larvae to the ototoxin neomycin during a 36 h period from 3 to 4 days post-fertil

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Upadhyay, Ratna, Mihir C. Gadani, and Sneha Badak. "Evaluating the hair regenerative potential of plant-based hair serum formulation: a comparative study." International Journal of Scientific Reports 11, no. 1 (2024): 20–24. https://doi.org/10.18203/issn.2454-2156.intjscirep20243799.

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Background: Hair loss, a multifactorial condition influenced by factors such as aging, hormonal imbalances, and genetics, has traditionally been treated with synthetic products like minoxidil and finasteride. However, these treatments often come with significant side effects, highlighting the need for safer and more effective alternatives. This study investigates the efficacy and safety of OZiva+ advanced hair growth serum, a formulation containing 3% Redensyl® and 1% Lindera root extract, as a potential treatment for hair loss. Methods: The serum's hair growth-promoting effects were evaluated

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Pessoa, Larissa Mota Barros, Lara Junqueira, and Thaina Candido De Souza. "Impacts of Personalized Multimodal Treatment in the Clinical Management of Androgenetic Alopecia: A Case Report." Brazilian Journal of Hair Health 2, no. 1 (2025): bjhh20. https://doi.org/10.62742/2965-7911.2025.2.bjhh20.

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Introduction: Androgenetic alopecia (AGA) is one of the most common forms of hair loss, characterized by the progressive miniaturization of hair follicles. The condition affects both men and women and has a significant impact on patients' self-esteem and psychological well-being. The treatment of AGA remains challenging, with available therapeutic options that do not always result in satisfactory outcomes. Methodology: This case study investigated the efficacy of a multimodal treatment for AGA, combining oral therapy, at-home topical care, microinfusion of specific active ingredients, and phot

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Anudeep, Talagavadi Channaiah, Madhan Jeyaraman, Sathish Muthu, et al. "Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia." Pharmaceutics 14, no. 3 (2022): 612. http://dx.doi.org/10.3390/pharmaceutics14030612.

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Alopecia or baldness is a common diagnosis in clinical practice. Alopecia can be scarring or non-scarring, diffuse or patchy. The most prevalent type of alopecia is non-scarring alopecia, with the majority of cases being androgenetic alopecia (AGA) or alopecia areata (AA). AGA is traditionally treated with minoxidil and finasteride, while AA is treated with immune modulators; however, both treatments have significant downsides. These drawbacks compel us to explore regenerative therapies that are relatively devoid of adverse effects. A thorough literature review was conducted to explore the exi

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Ramadan, Francesca. "Microneedling: monotherapy or adjuvant treatment?" Journal of Aesthetic Nursing 14, no. 1 (2025): 38–42. https://doi.org/10.12968/joan.2025.0004.

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Microneedling, a minimally invasive procedure involving repeated puncturing of the skin with sterilized microneedles, has gained popularity for treating various dermatological concerns. Its ability to stimulate collagen production makes it effective for skin rejuvenation, scar reduction, and hair regrowth. Recent studies demonstrate its enhanced efficacy when combined with other treatments, such as minoxidil, platelet-rich plasma, and exosomes for hair regeneration. Additionally, microneedling shows promise in managing conditions like vitiligo and melasma when used alongside topical therapies.

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Mirzadeh, Shila, Tahereh Hashesmi, Azam Mohammad Jafari, et al. "Combination of Low-Level Laser Therapy and Autologous Exosome Therapy in Hair Growth; Case Series." Scholars Journal of Medical Case Reports 12, no. 07 (2024): 1250–56. http://dx.doi.org/10.36347/sjmcr.2024.v12i07.011.

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Regenerative medicine methods in the beauty field have quickly attracted the attention of many doctors and scientists in recent years. These methods include cell therapy, exosome therapy, and laser therapy. Based on many studies, exosomes, play a decisive role in the body's regeneration process. On the other hand, many articles confirm that laser therapy with a very important mechanism is very effective in enhancing hair growth. In this article we want to show you examples of the very successful effects of the simultaneous application of laser therapy and autologous exosome therapy on voluntee

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Pece, Sherovski, and Ristovska Natasha. "Electrophoretic Analysis of Proteins of Chemical Treated Human." International Journal of Engineering Research & Science 4, no. 5 (2018): 38–42. https://doi.org/10.5281/zenodo.1256476.

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<strong><em>Abstract</em></strong><strong>—</strong> <em>S</em><em>t</em><em>r</em><em>ong oxidising agents for bleaching and chemical treatments for regeneration of dry and damaged hair are most common factors that cause changes in protein structure and composition. Composition changes in fibrillar proteins - α keratins and globular proteins - KAP's (keratin-associated proteins) were investigated by protein analysis of the hair fiber using SDS-PAGE. The most significant changes in obtained electrophoregrams from SDS-PAGE analysis of bleached hair were observed in matrix protei

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Bertagnoli, Lino E., Richard Seist, Shelley Batts, and Konstantina M. Stankovic. "Potential Ototoxicity of Insulin-like Growth Factor 1 Receptor Signaling Inhibitors: An In Silico Drug Repurposing Study of the Regenerating Cochlear Neuron Transcriptome." Journal of Clinical Medicine 12, no. 10 (2023): 3485. http://dx.doi.org/10.3390/jcm12103485.

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Spiral ganglion neurons (SGNs) connect cochlear hair cells with higher auditory pathways and their degeneration due to drug toxicity (ototoxicity) contributes to hearing loss. This study aimed to identify drug classes that are negatively correlated with the transcriptome of regenerating SGNs. Human orthologs of differentially expressed genes within the regenerating neonatal mouse SGN transcriptome were entered into CMap and the LINCS unified environment and perturbation-driven gene expression was analyzed. The CMap connectivity scores ranged from 100 (positive correlation) to −100 (negative co

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Randall, Valerie A., Tracey J. Jenner, Nigel A. Hibberts, Isabel O. De Oliveira, and Tayyebeh Vafaee. "Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair follicles." Journal of Endocrinology 197, no. 1 (2008): 11–23. http://dx.doi.org/10.1677/joe-07-0522.

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Androgens stimulate many hair follicles to alter hair colour and size via the hair growth cycle; in androgenetic alopecia tiny, pale hairs gradually replace large, pigmented ones. Since stem cell factor (SCF) is important in embryonic melanocyte migration and maintaining adult rodent pigmentation, we investigated SCF/c-Kit signalling in human hair follicles to determine whether this was altered in androgenetic alopecia. Quantitative immunohistochemistry detected three melanocyte-lineage markers and c-Kit in four focus areas: the epidermis, infundibulum, hair bulb (where pigment is formed) and

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Cyran, Piotr, Anna Jaroszyńska, Filip Jaroszyński, et al. "Platelet-Rich Plasma (PRP) in Hair Restoration Treatments: A Comprehensive Review of Existing Literature." Journal of Education, Health and Sport 70 (September 23, 2024): 55220. http://dx.doi.org/10.12775/jehs.2024.70.55220.

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Hair loss is a common concern affecting individuals worldwide. With various therapies available to address this issue, it prompts the search for effective treatments and prevention methods. Platelet-Rich Plasma (PRP) therapy has emerged as a promising option for hair restoration, leveraging the regenerative properties of platelets to stimulate hair growth. This comprehensive review aims to synthesize the existing literature on the use of PRP in hair restoration treatments. A systematic search of major databases was conducted to identify relevant studies evaluating the efficacy and safety of PR

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Gazizov, I. M., I. I. Salafutdinov, M. O. Mavlikeev, et al. "Application of genetically modified umbilical cord blood cells and direct gene therapy for treatment of skin wounds in rats." Genes & Cells 9, no. 3 (2014): 59–62. http://dx.doi.org/10.23868/gc120303.

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There were proposed several methods for stimulation of skin wound repair over the last few decades. The most perspective among them are gene and stem cell therapy. In our experiments we combined both approaches by application of human cord blood mononuclear cells (hUCB-MC) transfected with pBud-VEGF165-FGF2 plasmid to enhance healing of full thickness skin wounds in rats. Dual expression cassette plasmid pBud-VEGF165-FGF2 encodes both VEGF and FGF2 therapeutic genes, expressing pro-angiogenic growth factors. Our results showed that in 2 weeks after transplantation some transplanted cells still

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Rico-Leo, Eva María, Luis Francisco Lorenzo-Martín, Ángel Carlos Román, Xosé Ramón Bustelo, Jaime María Merino, and Pedro María Fernández-Salguero. "Aryl Hydrocarbon Receptor Controls Skin Homeostasis, Regeneration, and Hair Follicle Cycling by Adjusting Epidermal Stem Cell Function." Stem Cells 39, no. 12 (2021): 1733–50. http://dx.doi.org/10.1002/stem.3443.

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Abstract Skin integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. While interfollicular epidermal progenitors control normal homeostasis, hair follicle stem cells residing within the bulge provide regenerative potential during hair cycle and in response to wounding. The aryl hydrocarbon receptor (AhR) modulates cell plasticity and differentiation and its overactivation results in severe skin lesions in humans. However, its physiological role in skin homeostasis and hair growth is unknown. Reconstitution assays grafting primary keratinocytes and der

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Aphale, Parth, Snigdha Suman Dalua, Poorva Tiwari, and Ramachandran Valavan. "An Innovative Approach to Hair Regeneration: Synergistic Effects of Zauber™ Hair Drops and Zauberöl® Premium Hair Oil in Testosterone Induced Alopecia Rat Model." Advancements in Homeopathic Research 9, no. 1 (2024): 3–12. http://dx.doi.org/10.48165/ahr.2024.9.1.1.

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Introduction: Hair loss, or alopecia, is a prevalent concern with medical and cosmetic implications. Hair loss, attributed to genetic predisposition, hormonal imbalances, and psychosocial impacts, necessitates effective treatments. This study aims to assess the safety and efficacy of specific formulations Zauber™ Hair Drops (Zauber™) and Zauberöl® Premium Hair Oil (Zauberöl®) in addressing testosterone induced alopecia, utilizing a rat model. This research contributes to our understanding of potential solutions to the rising prevalence of this condition.Materials and Methods: 60 Male Wistar ra

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Wang, Changquan, Zhenmin Zhong, Peng Sun, Hanbing Zhong, Hongzhe Li, and Fangyi Chen. "Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses." Neural Plasticity 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/8283075.

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The zebrafish has become an established model organism for the study of hearing and balance systems in the past two decades. The classical approach to examine hair cells is to use dye to conduct selective staining, which shows the number and morphology of hair cells but does not reveal their function. Startle response is a behavior closely related to the auditory function of hair cells; therefore it can be used to measure the function of hair cells. In this study, we developed a device to measure the startle response of zebrafish larvae. By applying various levels of stimulus, it showed that t

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Ying, Ming, Jialin Zhou, Zuye Zeng, Shuangfei Li, and Xuewei Yang. "Effects of Nannochloropsis salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth." International Journal of Molecular Sciences 25, no. 15 (2024): 8231. http://dx.doi.org/10.3390/ijms25158231.

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The hair follicle is the basis of hair regeneration, and the dermal papilla is one of the most important structures in hair regeneration. New intervention and reversal strategies for hair loss may arise due to the prevention of oxidative stress. GC/MS analysis was used to determine the compounds contained in NSO. Then, NSO was applied to DPC for cell proliferation and oxidative stress experiments. RNA-seq was performed in cells treated with NSO and minoxidil. The quantitative real-time polymerase chain reaction (qRT-PCR) was applied to verify the gene expression. The effects of NSO on hair len

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Lin, Yali, Ruomei Shao, Tong Xiao, and Shuqing Sun. "Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles." Pharmaceutics 14, no. 7 (2022): 1404. http://dx.doi.org/10.3390/pharmaceutics14071404.

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Interest in transdermal delivery methods for stimulating hair regrowth has been increasing recently. The microneedle approach can break the barrier of the stratum corneum through puncture ability and improve drug delivery efficiency. Herein, we report a dissolvable microneedle device for the co-delivery of rapamycin and epigallocatechin gallate nanoparticles that can significantly promote hair regeneration. Compared with the mice without any treatment, our strategy can facilitate hair growth within 7 days. Higher hair shaft growth rate and hair follicle density with inconspicuous inflammation

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Carey, J. P., A. F. Fuchs, and E. W. Rubel. "Hair cell regeneration and recovery of the vestibuloocular reflex in the avian vestibular system." Journal of Neurophysiology 76, no. 5 (1996): 3301–12. http://dx.doi.org/10.1152/jn.1996.76.5.3301.

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1. Although auditory and vestibular hair cells are known to regenerate after aminoglycoside intoxication in birds, there is only sparse evidence that the regenerated hair cells are functional. To address this issue, we examined the relation of hair cell regeneration to recovery of the vestibuloocular reflex (VOR), whose afferent signal originates at hair cells in the vestibular epithelium. Hair cell damage was produced by treating white Leghorn chicks (Gallus domesticus, 4–8 days posthatch) with streptomycin sulfate in normal saline (1,200 mg.kg-1.day-1 im) for 5 days. 2. In the 1st wk after t

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Shin, Seung-Yeon, Jeong-Eun Kwon, Seonyu Kim, Yeong-Geun Lee, Soojin Park, and Se-Chan Kang. "Hair Regeneration Effects of Lespedeza bicolor Extract In Vivo and In Vitro." Applied Sciences 12, no. 6 (2022): 2863. http://dx.doi.org/10.3390/app12062863.

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Alopecia is a chronic inflammatory skin disease with various causes. Lespedeza bicolor extract (LBE) has been reported to have anti-inflammatory and antioxidative effects. In this study, the activity and mechanisms of LBE as a hair growth agent were investigated. Effects of cell proliferation, cytotoxicity, and cell cycle regulation of LBE and its active component protocatechuic acid (PCA) were evaluated in human dermal papilla cells (DPCs). Hair regeneration effects of LBE in 6-week-old C57BL/6 male mice were also determined using positive control 5% minoxidil. The dose-dependent proliferatio

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Rubel, Edwin W., Terance T. Tsue, Elizabeth C. Oesterle, and Edwin W. Rubel. "Hair Cell Regeneration in the Inner Ear." Otolaryngology–Head and Neck Surgery 111, no. 3P1 (1994): 281–301. http://dx.doi.org/10.1177/01945998941113p118.

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Hearing and balance disorders caused by the loss of inner ear hair cells Is a common problem encountered in otolaryngology-head and neck surgery. The postembryonic production of hair cells in cold-blooded vertebrates has been known for several decades, and recent studies in the avian inner ear after ototoxic drug and noise damage have demonstrated a remarkable capacity for both anatomic and functional recovery. The regeneration of sensory hair cells has been shown to be integral to this repair process. Current work is focusing on the cellular progenitor source of new hair cells and the trigger

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Drašković-Radojković, Danijela. "The importance of biomedical engineers in the health system." Tehnika 78, no. 3 (2023): 363–68. http://dx.doi.org/10.5937/tehnika2303363d.

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We are witnessing an epidemiological increase in the development of chronic diseases. In particular, this growth trend refers to malignant, autoimmune and metabolic diseases. Despite the sovereignty of medicine in the treatment of acute conditions, there is a significant problem with the diagnosis, prevention and treatment of chronic diseases. Autoimmune diseases occur when the immune system loses its immune memory and begins to recognize the cells of its own organism as foreign and to attack and destroy them. There can be an attack of only one organ or several organs, that is, the emergence o

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Ryu, Yeong Chan, You-Rin Kim, Jiyeon Park та ін. "Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling". Pharmaceutics 14, № 12 (2022): 2774. http://dx.doi.org/10.3390/pharmaceutics14122774.

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Hair follicle stem cells (HFSCs) utilize glycolytic metabolism during their activation and anagen induction. However, the role of pyruvate kinase M2 (PKM2), which catalyzes the final step of glycolysis, in hair regeneration has not been elucidated. In this study, we investigated the expression pattern and activity of PKM2 during the depilation-induced anagen progression in mice. We found that TEPP-46, a selective activator of PKM2, enhanced hair re-growth and proliferation of HFSCs. PKM2 expression was increased via up-regulation of Wnt/β-catenin signaling, which is involved in hair regenerati

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Song, Jinzhi, Yun Li, Yang Wang, et al. "Preparing Biochars from Cow Hair Waste Produced in a Tannery for Dye Wastewater Treatment." Materials 14, no. 7 (2021): 1690. http://dx.doi.org/10.3390/ma14071690.

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A large amount of cow hair solid waste is produced in leather production, and a reasonable treatment should be developed to reduce the pollution. In this study, cow hair waste was utilized as the carbon precursor, and N2 was determined to be the most appropriate atmosphere for biochar preparation. We performed a comparison of the properties of biochars that were prepared with different methods, including direct pyrolysis, KOH activation, and the MgO template method. The characterization results show that the highest specific surface area reaches 1753.075 m2/g. Subsequently, the keratin that wa

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Rajendran, Ramya Lakshmi, Prakash Gangadaran, Chang Hoon Seo, et al. "Macrophage-Derived Extracellular Vesicle Promotes Hair Growth." Cells 9, no. 4 (2020): 856. http://dx.doi.org/10.3390/cells9040856.

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Hair loss is a common medical problem affecting both males and females. Dermal papilla (DP) cells are the ultimate reservoir of cells with the potential of hair regeneration in hair loss patients. Here, we analyzed the role of macrophage-derived Wnts (3a and 7b) and macrophage extracellular vesicles (MAC-EVs) in promoting hair growth. We studied the proliferation, migration, and expression of growth factors of human-DP cells in the presence or absence of MAC-EVs. Additionally, we tested the effect of MAC-EV treatment on hair growth in a mouse model and human hair follicles. Data from western b

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Ferruggia, Greta, Martina Contino, Massimo Zimbone, and Maria Violetta Brundo. "Effectiveness of a Novel Compound HAIR & SCALP COMPLEX on Hair Follicle Regeneration." Cosmetics 11, no. 1 (2024): 10. http://dx.doi.org/10.3390/cosmetics11010010.

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Background: People lose between 50 and 100 hairs a day and generate new ones from stem cells in hair follicles, but in those suffering from baldness, the stem cells remain inactive and are unable to regenerate new hair. Although 9% of hair follicles remain in telogen at any time, a variety of factors, including growth factors and cytokines, promote the transition from telogen to anagen and the subsequent stimulation of hair growth. Methods: We compared in vitro, on cultures of human hair follicles, the effect on hair growth and regeneration of the dermal papilla of plant-derived nanovesicles,

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Xin, Ying, Kwok Ming Hei, Nelson Cheuk Yin Lai, Kam-Chau Wu, Dominic Man Kit Lam, and Keith Wai-Yeung Kwong. "Hair regeneration using microneedle-assisted human basic fibroblast growth factor." Journal of Analytical & Pharmaceutical Research 12, no. 2 (2023): 95–100. http://dx.doi.org/10.15406/japlr.2023.12.00429.

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Hair loss has afflicted numerous patients for several decades. However, the current drug treatment is only effective for specific types of alopecia and their efficacy is limited. Additionally, the cost of hair transplant surgery is relatively high, making it unaffordable for some patients. In this study, we propose a new treatment method using microneedles and growth factors to alleviate alopecia. The results of our study demonstrate that patients receiving human basic fibroblast growth factor (hbFGF) therapy experienced significant hair regeneration. Both male and female patients responded po

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Wang, Minghui, Shangsheng Yao, Dehua He, et al. "Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice." Journal of Diabetes Research 2022 (April 16, 2022): 1–15. http://dx.doi.org/10.1155/2022/8938276.

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Background. Hair follicles are important accessory organs of the skin, and it is important for skin renewal and performs variety of important functions. Diabetes can cause several dermatoses; however, its effect on hair follicles is unclear. The purpose of this study was to investigate the effect of type II diabetes (T2DM) on the hair follicles of mice. Methods. Seven-week-old male C57BL/6 littermate mice were divided into two groups. The treatment group was injected with streptozotocin (STZ) to induce T2DM, and the control group was parallelly injected with the same dose of buffer. Seven days

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Choi, Bu Young. "Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss". International Journal of Molecular Sciences 21, № 14 (2020): 4915. http://dx.doi.org/10.3390/ijms21144915.

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activati

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Thitipramote, Natthawut, Supapong Imsonpang, Passanesh Sukphopetch, et al. "Health Benefits and Safety of Red Pigmented Rice (Oryza sativa L.): In Vitro, Cellular, and In Vivo Activities for Hair Growth Promoting Treatment." Cosmetics 9, no. 6 (2022): 111. http://dx.doi.org/10.3390/cosmetics9060111.

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The hair growth-promoting activities of Thai native red (Sang-Yod-SY and Mun-Poo-MP) and black (Black glutinous-BG and Hom-Nil-HN) pigmented rice (Oryza sativa L.) extracts, including in vitro 5α-reductase inhibition, hair growth-promoting activity on human hair germinal matrix cells, and in vivo hair-cycle-converting activity in C3H/HeMlac mice, were investigated. Moreover, these extracts were determined to be safe via cytotoxicity (HaCaT cell) and in vivo irritation tests. The results showed that SY red rice extract with high contents of proanthocyanidin (1.50 ± 0.16 mgECE/g extract) exhibit

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Parvez, Zahed, Samina Akter, and Afia Tahsin Shobnom. "Usefulness of PRP Therapy in Androgenic Alopecia." European Journal of Medical and Health Sciences 3, no. 3 (2021): 93–95. http://dx.doi.org/10.24018/ejmed.2021.3.3.897.

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Alopecia means loss of hair. Primarily there are two types of alopecia. Non-cicatricial alopecia and Cicatricial alopecia. Androgenic alopecia is non cicatricial localized alopecia and displays relatively high rates of occurrence in both men and women. Injections of platelet-rich plasma (PRP) have shown to be a successful regenerative treatment for androgenic alopecia. It is a well-tolerated procedure and easy to perform. The objective clinical results are good. It is safe and non-allergenic. In our institution, more than 300 patients were given PRP and their terminal hair mass, hair texture,

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Llamas-Molina, José María, Alejandro Carrero-Castaño, Ricardo Ruiz-Villaverde, and Antonio Campos. "Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review." Life 12, no. 1 (2022): 117. http://dx.doi.org/10.3390/life12010117.

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Androgenetic alopecia (AGA) is an androgen-dependent process and represents the most frequent non-scarring alopecia. Treatments for AGA do not always achieve a satisfactory result for the patient, and sometimes cause side effects that lead to discontinuation of treatment. AGA therapeutics currently includes topical and oral drugs, as well as follicular unit micro-transplantation techniques. Tissue engineering (TE) is postulated as one of the possible future solutions to the problem and aims to develop fully functional hair follicles that maintain their cyclic rhythm in a physiological manner.

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Hu, Shiqi, Zhenhua Li, Halle Lutz та ін. "Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling". Science Advances 6, № 30 (2020): eaba1685. http://dx.doi.org/10.1126/sciadv.aba1685.

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The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of p

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Li, Rong, Xin Yuan, Li Zhang, et al. "3D printing of microneedle arrays for hair regeneration in a controllable region." Molecular Biomedicine 4, no. 1 (2023). http://dx.doi.org/10.1186/s43556-022-00102-2.

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AbstractHair loss is a common skin disease that causes intense emotional suffering. Hair regeneration in a personalized area is highly desirable for patients with different balding conditions. However, the existing pharmaceutical treatments have difficulty precisely regenerating hair in a desired area. Here, we show a method to precisely control the hair regeneration using customized microneedle arrays (MNAs). The MNA with a customized shape is fast fabricated by a static optical projection lithography process in seconds, which is a 3D printing technology developed by our group. In the mouse m

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Lee, Jung Hyun, and Sekyu Choi. "Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration." Experimental & Molecular Medicine, January 5, 2024. http://dx.doi.org/10.1038/s12276-023-01151-5.

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AbstractHair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activity of melanocyte stem cells, which differentiate into melanin-producing melanocytes, contributing to skin and hair pigmentation. Sebaceous gland stem cells also have a pivotal role in maintaining the skin barrier by regenerating mature sebocytes. These stem cells are maintained in a specialized microe

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Pappalardo, Alberto, Jin Yong Kim, Hasan Erbil Abaci, and Angela M. Christiano. "Restoration of hair follicle inductive properties by depletion of senescent cells." Aging Cell, November 29, 2024. https://doi.org/10.1111/acel.14353.

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AbstractSenescent cells secrete a senescence‐associated secretory phenotype (SASP), which can induce senescence in neighboring cells. Human dermal papilla (DP) cells lose their original hair inductive properties when expanded in vitro, and rapidly accumulate senescent cells in culture. Protein and RNA‐seq analysis revealed an accumulation of DP‐specific SASP factors including IL‐6, IL‐8, MCP‐1, and TIMP‐2. We found that combined senolytic treatment of dasatinib and quercetin depleted senescent cells, and reversed SASP accumulation and SASP‐mediated repressive interactions in human DP culture,

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Khalaily, Lama, and Karen B. Avraham. "Insights into the regulation of hearing regeneration." Frontiers in Audiology and Otology 2 (June 26, 2024). http://dx.doi.org/10.3389/fauot.2024.1404617.

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Our perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway. A major cause of hearing loss is damage to and the death of these sensory hair cells. In humans, hair cells are only generated during embryonic development and cannot be replaced if damaged due to aging, excessive noise, ototoxic drugs, or illness. Much research is currently being invested worldwide in identifying methods to improve the ability to regenerate hair cells and circumvent their age-d

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Qi, Jieyu, Wenjuan Huang, Yicheng Lu, et al. "Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear." Neuroscience Bulletin, October 3, 2023. http://dx.doi.org/10.1007/s12264-023-01130-w.

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AbstractHearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of hair cells is a main cause of sensorineural hearing loss, and currently, the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids, but these are of limited benefit in patients. It is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective strategies. At present, how to promote the regeneration of functional hair cells is a

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Maia, Matoshvili, and Tophuria Davit. "CELLULAR THERAPY AND STEM CELL USAGE DURING HAIR LOSS: FUTURE PERSPECTIVES." June 24, 2020. https://doi.org/10.5281/zenodo.3906293.

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Stem cells may have potential as a treatment for regenerating hair. Initially, methods to obtain stem cells have concentrated on isolating the primary cells from the tissue of interest through biopsy and growing these cells outside the body to be transplanted into the patient. Stem cell treatment of nonautoimmune hair loss like androgenetic alopecia is promising. Although an autologous transplant is viewed as the standard, its use is limited because of a lack of data and the diminished viability of cells that are made available using this method. Adipose-derived stem cells are a promising alte

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