Relevant bibliographies by topics / Treatment of squamous cell carcinoma of the oral cavity

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  2. Dissertations / Theses
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Academic literature on the topic 'Treatment of squamous cell carcinoma of the oral cavity'

Author: Grafiati
Published: 8 September 2021
Last updated: 14 February 2022

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Journal articles on the topic "Treatment of squamous cell carcinoma of the oral cavity"

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Hoffman, Henry T., Gerry F. Funk, Timothy M. McCulloch, and Scon Graham. "Cost Analysis of Treatment of Oral Cavity Squamous Cell Carcinoma." Otolaryngology–Head and Neck Surgery 113, no. 2 (August 1995): P50. http://dx.doi.org/10.1016/s0194-5998(05)80575-3.

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Patni, Parth, Deepak Dalmia, Narsinha Davange, Karthika Bhagavan, Amit Palwade, and Rizul Goyal. "Level IIb involvement in oral cavity squamous cell carcinoma." International Journal of Otorhinolaryngology and Head and Neck Surgery 7, no. 2 (January 25, 2021): 292. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20210159.

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<p><strong>Background:</strong> Cervical lymph node status is the most significant prognostic factor in the treatment of patients with OSCC. Adequate clearance of level IIb lymph nodes require traction and elevation of the spinal accessory nerve (SAN) and can lead to consequent shoulder problems.Therefore, avoiding the dissection of level IIb has been increasingly proposed to overcome this complication. The aim of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs).</p><p><strong>Methods: </strong>A total of 106 newly diagnosed oral cavity cancer patients requiring surgery as the primary modality were included in the study. Preoperative clinical examinations were done and tumor-node-metastasis staging was noted. Intraoperative, level IIb nodal tissue was dissected and sent separately.</p><p><strong>Results: </strong>A total of 106 neck dissections were done out of which male: female ratio of 2.78:1. 49.05% patients were suffering from buccal mucosa carcinoma followed by tongue carcinoma (22.64%). 52.83% of patients had no neck involvement. Among neck positive cases, pN1 was the most common presentation. Out of these, only 8 (7.54%) neck dissections had level IIb positive.</p><p><strong>Conclusions: </strong>Dissection of the level IIb region in patients with OSCC may be required only in cases with advanced N stage, positive level IIa lymph nodes, and extra capsular spread. Further evaluation can be done among various subsites of OSCC, clinical staging of tumour, occult bilateral nodal metastasis to assess the need of resection of level IIb in OSCC.</p>
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Su, Nai-Wen, and Yu-Jen Chen. "Metronomic Therapy in Oral Squamous Cell Carcinoma." Journal of Clinical Medicine 10, no. 13 (June 26, 2021): 2818. http://dx.doi.org/10.3390/jcm10132818.

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Metronomic therapy is characterized by drug administration in a low-dose, repeated, and regular manner without prolonged drug-free interval. The two main anticancer mechanisms of metronomic therapy are antiangiogenesis and immunomodulation, which have been demonstrated in several delicate in vitro and in vivo experiments. In contrast to the traditional maximum tolerated dose (MTD) dosing of chemotherapy, metronomic therapy possesses comparative efficacy but greatlydecreases the incidence and severity of treatment side-effects. Clinical trials of metronomic anticancer treatment have revealed promising results in a variety cancer types and specific patient populations such as the elderly and pediatric malignancies. Oral cavity squamous cell carcinoma (OCSCC) is an important health issue in many areas around the world. Long-term survival is about 50% in locally advanced disease despite having high-intensity treatment combined surgery, radiotherapy, and chemotherapy. In this article, we review and summarize the essence of metronomic therapy and focus on its applications in OCSCC treatment.
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Patil, Seema, Manmita Das, Asha R. Iyengar, Subash B.V, Ritika Agarwal, and Aparna S. Namboothiri. "GINGIVAL SQUAMOUS CELL CARCINOMA- A CASE REPORT." International Journal of Advanced Research 8, no. 11 (November 30, 2020): 548–53. http://dx.doi.org/10.21474/ijar01/12040.

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Gingival squamous cell carcinoma (GSCC) is a relatively rare malignant neoplasm of the oral cavity. It represents less than 4-6.3% of diagnosed intraoral carcinomas. GSCC may cause odontogenic symptoms such as mobility and pain of teeth mimicking inflammatory conditions such as periodontitis. Early diagnosis and prompt management of GSCC is of paramount importance as the prognosis of gingival squamous cell carcinoma is mainly dependent on these factors. Further, as, GSCCs spread rapidly to involve the underlying bone, the role of dentists in early detection of gingival squamous cell carcinoma cannot be undermined. The present report describes a rare case of GSCC in a 31 year old male. The detailed recording of the case history and clinical examination, radiographic, and laboratory investigations, along with review of similar conditions led to the diagnosis, and treatment was initiated.
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Israyani, Israyani, Ayu F. Argadianti, Hening Tuti Hendarti, and Adiastuti E. P. "Managementof squamos cell carcinoma of tongue in young men: case report." Journal of Case Reports in Dental Medicine 1, no. 1 (May 1, 2019): 21. http://dx.doi.org/10.20956/jcrdm.v1i1.95.

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Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap
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Palme, Carsten E., Patrick J. Gullane, and Ralph W. Gilbert. "Current treatment options in squamous cell carcinoma of the oral cavity." Surgical Oncology Clinics of North America 13, no. 1 (January 2004): 47–70. http://dx.doi.org/10.1016/s1055-3207(03)00123-6.

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Ye, Gang, Gary V. Burton, Cherie-Ann O. Nathan, and Federico L. Ampil. "Squamous Cell Carcinoma of the Oral Cavity Following Breast Cancer Treatment." Southern Medical Journal 99, no. 10 (October 2006): 1150–51. http://dx.doi.org/10.1097/01.smj.0000240721.53724.98.

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Schwartz, Glenn J., Rajeev H. Mehta, Barry L. Wenig, Chitra Shaligram, and Louis G. Portugal. "Salvage treatment for recurrent squamous cell carcinoma of the oral cavity." Head & Neck 22, no. 1 (January 2000): 34–41. http://dx.doi.org/10.1002/(sici)1097-0347(200001)22:1<34::aid-hed6>3.0.co;2-3.

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CS, Ng, Mohd Razif M. Y, Chew MX, and Suria HMP. "Spindle Cell Carcinoma of Oral Cavity: A Rare Entity." Bangladesh Journal of Medical Science 20, no. 4 (June 18, 2021): 923–25. http://dx.doi.org/10.3329/bjms.v20i4.54154.

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Introduction:Spindle cell carcinomas (SpCC) are a rare variant of squamous cell carcinoma which is rarely encountered in the head and neck. It is also known as“pseudocarcinoma”, “sarcomatoidcarcinoma,” and “carcinosarcoma”.It has an aggressive nature and has poor prognosis despite aggressive treatment. Case report: A 48-year-old lady presented to us with a right painless upper gum swelling which was progressively enlarging for 3 months after tooth extraction. Examination of the oral a fungating mass over the right upper alveolus extending to the right upper gingivolabial sulcus. She was subjected to a debulking palliative to reduce the tumour bulk. The intraoperative samples sent for histopathological examination was reported as SpCC, AJCC (8th edition) stage pT2pN3b. She recovered well after the surgery with quality of life after the surgery. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.923-925
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Sultana, N., Q. B. Rahman, S. Alam, Md M. Karim, and Md F. Kabir. "Effect of Neoadjuvant Chemotherapy on the Size of Lesion in Oral Squamous Cell Carcinoma." Journal of Medical Science & Research 21, Number 2 (July 1, 2013): 9–17. http://dx.doi.org/10.47648/jmsr.2013.v2102.02.

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A prospective randomized trial was performed to evaluate the combination of neoadjuvant chemotherapy in patient with oral squamous cell carcinoma. Prognosis of patient with squamous cell carcinoma in oral cavity is worth improving. Chemotherapy has been reported specially active in oral cavity tumour. It has been enrolling patients with stage T2, T3, T4 NO NI N2 MO untreated squamous cell carcinoma in oral cavity. Number of patients in this study was 25, suffering from squamous cell carcinoma. This study was a Prospective study conducted among the randomly selected 25 cases of histopathologically diagnosed Squamous cell carcinoma patients from the Department of Oral and Maxillofacial surgery Bangabandhu Sheikh Mujib Medical University and Department of Oncology Bangabandhu Shiekh Mujib Medical university . Both male and female were included and assigned for three cycles of cisplatin and 5fluorouracil followed by definitive treatment. The study was done between January 2007 to December 2008. 25 patients were included in this study, 21.7% patients showed complete response and 84.2% showed partial response. Out of 25, 20.0% patients mouth opening were reduced and 4.0% patients mouth opening were improved. After taking computed tomography all patient showed tumour progression. Histopathologically only 1 patient showed complete response among 25 which is not signcant. Neoadjuvant chemotherapy reduced the size of the lesion clinically. Results down staging of the tumour but histologically it was not given any significant changes. So probably neoadjuvant chemotherapy is unable to fulfill our desire expectation.
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Dissertations / Theses on the topic "Treatment of squamous cell carcinoma of the oral cavity"

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Högmo, Anders. "Squamous cell carcinomas and preneoplastic lesions of the oral cavity : biological factors and prognosis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3370-7/.

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Yoshikawa, Hiroto. "Feline oral squamous cell carcinoma| A comprehensive approach to improve treatment outcome." Thesis, Colorado State University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3593468.

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Feline oral squamous cell carcinoma (SCC) is a devastating disease that responds poorly to traditional treatment modalities. The tumor location directly impacts the patient's ability to eat and drink, and immediate intervention to alleviate clinical signs is important. To design better treatment strategies it is paramount to understand the underlying biological behavior of this poorly defined tumor. This research takes a comprehensive approach in attempt to understand this disease. A number of assays have been developed and applied to elucidate underlying biology. New imaging modalities have been used to better stage the disease and define tumor location. Finally, patients were treated with a new radiation therapy modality, stereotactic radiation therapy (SRT), and outcome was correlated with the biological assays for potential predictive value.

The goal of the prospective study described in Chapter 2 was to compare gross tumor volume measurements using 18F-FDG PET vs. those using computed tomography (CT) for SRT planning in cats with oral SCC. Twelve cats with confirmed oral SCC underwent pretreatment 18F-FDG PET/CT. Gross tumor volumes based on contrast-enhanced CT and 18F-FDG PET were measured and compared between cats. Mean PET gross tumor volume was significantly smaller than mean CT gross tumor volume in the mandibular/maxillary SCC group (n=8, P=0.002) and for all cats (n=12, P=0.006), but not for cats with lingual/laryngeal SCC (n=4, P=0.57). Mismatch fraction analysis revealed that most of the lingual/laryngeal patients had a large region of high-18F-FDG activity outside of the CT gross tumor volume. This mismatch fraction was significantly greater in the lingual/laryngeal group than the mandibular/maxillary group ( P=0.028). The effect of poor spatial resolution of PET imaging was greater when the absolute tumor volume was small. Findings from this study indicated that 18F-FDG PET warrants further investigation as a supplemental imaging modality in cats with oral SCC because it detected presumed regions of primary tumor that were not detected on CT images.

For canine and feline patients with tumors in the head region, simultaneous irradiation of the primary tumor and mandibular and retropharyngeal lymph nodes (LNs) is often indicated. The purpose of this study described in Chapter 3 was to assess the reliability of a planning target volume (PTV) expansion protocol for secondary targets (LNs).

Information about the molecular biology of feline oral SCC is still limited. In Chapter 4, 22 archived tumor samples of feline oral SCC were evaluated to develop immunohistochemical assays and to determine if there was correlation to clinical parameters. Immunohistochemistry for Ki67, MVD, and EGFR was performed and scored. Patient survival information was obtained from the medical records. These molecular markers as well as MI were correlated with tumor locations and patient survival time. The 22 tumors showed wide variation in Ki67, MI, MVD, and EGFR. Tongue SCC expressed higher MVD than mandibular/maxillary SCC (P=0.088).

Cancer stem cell or tumor initiating cell (TIC) theory and telomere biology are actively studied fields in human head and neck (H&N) cancer. In feline oral SCC, which has been advocated as a feline model for human H&N cancer, our knowledge about the TIC and telomere/telomerase biology is limited. Protein expression levels of putative TIC markers of human H&N cancer, CD44 and Bmi-1, were immunohistochemically evaluated for their possible role as prognostic markers in 20 patients with feline oral SCC who underwent SRT. This patient population was part of a clinical trial and information relevant to PFI and ST was available. A combined technique of fluorescent in-situ hybridization and immunofluorescent staining was used to determine telomere length ratio (fractions of very short telomere/average length telomere in the putative cancer stem cells) in the putative TICs that were positive for CD44 and Bmi-1. This was also correlated with treatment outcome. (Abstract shortened by UMI.)

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Anand, Sumeet M. 1978. "The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111587.

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The Tumour-Node-Metastasis (TNM) classification system of tumour stage does not always reflect the actual tumour mass present at diagnosis. Recent reports propose that volumetric analysis may allow improved stratification of disease recurrence and survival in head and neck squamous cell cancer (SCC). This study aims to assess the prognostic value of tumour volume on the outcome of patients with oral cavity and oropharyngeal SCC.
A retrospective review of 73 patients was completed. Tumours were outlined semi-automatically in digitized computed tomography scans, and volumes computed based on surface triangulations of three-dimensional reconstructions with novel software developed at McGill.
Results illustrate significant interstage variability within the current TNM model. Moreover, in oral cavity and oropharyngeal SCC, tumour volume as well as T-stage are significant and independent predictors of disease free survival and overall survival.
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Martin, Chelsea Kathleen. "Mechanisms and Treatment of Bone Resorption in Models of Oral Squamous Cell Carcinoma." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1285015046.

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Jatana, Courtney Ann. "Histopathological Characteristics in Squamous Cell Carcinoma of the Oral Cavity with Regard to Presence of Circulating Tumor Cells." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313587893.

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Marinho, Erasmo Bernardo. "Evaluation of the quality of life of post- irradiated patients diagnosed with squamous cell carcinoma of the oral cavity." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16162.

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Radiotherapy is an effective therapeutic modality employed in the management of malignant tumors in the oral cavity. Its use in head and neck results in adverse effects. The measurement of quality of life allows to gather the most common problems in oral cancer patients in a structured way, ranking its intensity and enabling a more accurate clinical control. This study aimed to evaluate the quality of life of post- irradiated diagnosed with squamous cell carcinoma of the oral cavity. Eleven patients over six months of completion of therapy treated at the Hospital Haroldo JuaÃaba â Instituto do CÃncer do Cearà were included in the study. University of Washington quality of life questionnaire, specific to head and neck cancer, was applied. Data related to socio-demographic, clinical, pathological and therapeutic profile were collected. Unstimulated salivary flow was measured by spitting method. Categorical data were exposed in the form of absolute and percentage frequency, and quantitative data as mean  standard deviation, followed by their minimum and maximum. Statistical analysis of quantitative data was performed by nonlinear Spearman correlation, considering a 95% confidence. Most patients were elderly (72.72%), male (81.81%), with lower education (90.9%), away from their work activities since the completion of cancer treatment (90.9%), with a history of smoking (90.9%), alcohol abuse (90.9%) and exposure to sunlight before the onset of the disease (90.9%), with lesions in the mouth floor (45.45%) moderately differentiated type (100%), stage IV (54,54%), subjected to other treatment modalities in addition to radiation therapy (100%). Among the domains assessed, chewing, saliva and speech presented the lowest mean scores (31.8, 42.3 and 60.6, respectively). All participants presented moderate to severe hyposalivation. Statistically significant correlation was found between age and speech (p = 0.043); time of completion of radiation therapy and recreation (p = 0.027); swallowing and pain (p = 0.039); activity and recreation (p = 0.030); swallowing and chewing (p = 0.007); chewing and speaking (p = 0.048); and shoulder and mood (p = 0.004). We conclude that the post- irradiated patients diagnosed with squamous cell carcinoma of the oral cavity tend to consider their quality of life ranging from fair to outstanding and that chewing, saliva and speech domains are those with greater commitment.
A radioterapia à uma modalidade terapÃutica eficaz utilizada no tratamento de tumores malignos da cavidade oral. Sua utilizaÃÃo em regiÃo de cabeÃa e pescoÃo leva ao surgimento de efeitos adversos. A mensuraÃÃo da qualidade de vida permite reunir os problemas mais comuns aos pacientes com cÃncer oral de forma estruturada, classificando sua intensidade, tornando-se possÃvel um controle clÃnico mais apurado. O presente estudo teve como objetivo avaliar a qualidade de vida de pÃs-irradiados com diagnÃstico de carcinoma espinocelular de cavidade oral. Onze pacientes com mais de seis meses de conclusÃo do tratamento, atendidos no Hospital Haroldo JuaÃaba â Instituto do CÃncer do CearÃ, foram incluÃdos no estudo. Foi aplicado o questionÃrio de qualidade de vida da Universidade de Washington, especÃfico para o cÃncer de cabeÃa e pescoÃo. Foram coletados dados relacionados ao perfil sociodemogrÃfico, clÃnico-patolÃgico e terapÃutico. Realizou-se a mensuraÃÃo do fluxo salivar nÃo estimulado atravÃs do mÃtodo de spitting. Dados categÃricos foram expostos em forma de frequÃncia absoluta e percentual e os dados quantitativos em forma de mÃdia  desvio-padrÃo, seguido de sua mÃnima e mÃxima. A anÃlise estatÃstica dos dados quantitativos foi realizada atravÃs da correlaÃÃo nÃo linear de Spearman, considerando uma confianÃa de 95%. Predominaram pacientes idosos (72,72%), do sexo masculino (81,81%), de baixa escolaridade (90,9%), afastados de suas atividades laborais desde a conclusÃo do tratamento oncolÃgico (90,9%), com histÃrico de tabagismo (90,9%), abuso de Ãlcool (90,9%) e exposiÃÃo à luz solar anterior ao surgimento da doenÃa (90,9%), com lesÃes localizadas em soalho de boca (45,45%) do tipo moderadamente diferenciado (100%), estadiamento IV (54,54%), submetidas a outras modalidades de tratamento alÃm da radioterapia (100%). Dentre os domÃnios avaliados, mastigaÃÃo, saliva e fala apresentaram as menores mÃdias de escores (31,8; 42,3 e 60,6, respectivamente). Todos os participantes apresentaram hipossalivaÃÃo de moderada à severa. Constatou-se correlaÃÃo estatisticamente significante entre: idade e fala (p=0,043); tempo de conclusÃo da radioterapia e recreaÃÃo (p=0,027); dor e deglutiÃÃo (p=0,039); atividade e recreaÃÃo (p=0,030); deglutiÃÃo e mastigaÃÃo (p=0,007); mastigaÃÃo e fala (p=0,048); e ombro e humor (p=0,004). Conclui-se que os pacientes pÃs-irradiados com diagnÃstico de carcinoma espinocelular de cavidade oral tendem a considerar de mÃdia a excelente sua qualidade de vida e que os domÃnios de mastigaÃÃo, saliva e fala sÃo os que apresentam maior comprometimento.
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El-Hakim, Ibrahim El-Sayed M. "Study of the 5-lipoxygenase pathway of arachidonic acid metabolism (leukotrienes) in squamous cell carcinoma of the oral cavity." Thesis, King's College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669048.

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Abreu, Priscila Marinho de. "HPV e Expressão de p16 como biomarcadores de prognósticos em carcinoma de células escamosas da cavidade bucal." Universidade Federal do Espírito Santo, 2015. http://repositorio.ufes.br/handle/10/4505.

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HPV e Expressão de p16 como Biomarcadores de Prognósticos em Carcinoma de Células Escamosas da Cavidade Bucal
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Abreu, Priscila Marinho de. "HPV e expressão de p16 como biomarcadores de prognóstico em carcinoma de células escamosas da cavidade bucal." Mestrado em Biotecnologia, 2015. http://repositorio.ufes.br/handle/10/1881.

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Biomarcadores de progressão tumoral são importantes na determinação do prognóstico e resposta ao tratamento em carcinoma de células escamosas da cavidade bucal. Este estudo teve como objetivo avaliar a frequência de infecção pelo HPV e a expressão de p16 como biomarcador de prognóstico em carcinoma de células escamosas da cavidade bucal. Dados clínico-patológicos e tecido tumoral de 90 indivíduos com carcinoma de células escamosas da cavidade bucal foram obtidos por entrevista e análise de prontuários. Detecção de HPV foi realizada à partir de amostras de tecido tumoral por PCR utilizando o conjunto de primers PGMY09/11. A seguir, as mesmas amostras foram submetidas à PCR com os primers MY09/11 e nested PCR com os primers GP5+/6+. Expressão de p16 foi detectada por imunohistoquímica. Análise estatística foi feita através de associação de variáveis, utilizando o teste de qui-quadrado e exato de Fisher. Sobrevida doença-específica (SDE) e sobrevida livre de doença (SLD) foram estimadas usando método de Kaplan-Meier. Comparação entre as curvas de sobrevida foram realizadas com o teste Log-Rank. Comparação entre status da infecção pelo HPV e expressão de p16 foram analisadas pelo teste Cox. Todos os testes com P ≤ 0.05 foram considerados significantes. A frequência de infecção pelo HPV na população estudada foi de 3,70% detectadas apenas com a nested PCR. Expressão de p16 foi observada em 21,87% das amostras analisadas. A SDE foi de 25,5 meses (95% IC = 20,03 - 31,00), enquanto a SLD foi de 30 meses (95% IC = 25,63 – 34,48). Maior SDE foi observada em indivíduos com tumores em estádio inicial (I-II) (P=0,001), tumores < 2cm (P=0,001), sem metástase em linfonodos regionais (P=0,006) e aqueles submetidos a tratamento cirúrgico (P<0,0001). Em conclusão, o status da infecção pelo HPV não mostrou-se um bom marcador de prognóstico e parece não ser determinante na tumorigênese em CCE da cavidade bucal, uma vez que apresentou baixa frequência de infecção. A expressão de p16 não foi um indicador determinante da presença de HPV nas amostras estudadas e um maior número de casos é necessário para avaliar sua aplicabilidade como marcador de prognóstico na população estudada.
Tumor progression biomarkers are important in determining prognosis and treatment response in squamous cell carcinoma of the oral cavity. This study aimed to evaluate the frequency of HPV infection and p16 expression as a biomarker of prognosis in squamous cell carcinoma of the oral cavity. Clinicopathological data and tumor tissue of 90 patients with squamous cell carcinoma of the oral cavity were obtained by interview and review of medical records. HPV detection was performed starting from tumor tissue samples by PCR using the primer set PGMY09/11. Next, the same samples were subjected to PCR with primers MY09 / 11 primers and nested PCR with GP5+/6+ primers. P16 expression was detected by immunohistochemistry. Statistical analysis was performed using variable association, using the chi-square and Fisher exact test. Disease-specific survival (DSS) and disease-free survival (DFS) were estimated using Kaplan-Meier. Comparison between the survival curves were performed using the log-rank test. Comparison status of HPV infection and p16 expression were analyzed by Cox test. All tests with P≤0,05 were considered significant. The frequency of HPV infection in this population was 3,70% detected only with nested PCR. p16 expression was observed in 21.87% of the analyzed samples. The DSS was 25.5 months (95% CI = 20.03 to 31.00), while the DFS was 30 months (95% CI = 25.63 to 34.48). Most DSS was observed in subjects with initial stage tumors (I-II) (P=0,001), tumor <2 cm (P=0,001), without regional lymph node metastasis (P=0,006) and those undergoing surgical treatment (P<0,0001). In conclusion, the status of HPV infection not proved to be a good prognostic marker and does not seem to be decisive in tumorigenesis in SCC of the oral cavity, since it showed low frequency of infection. The expression of p16 was not a key indicator of the presence of HPV in all samples and a greater number of cases it is necessary to evaluate its applicability as a prognostic marker in this population.
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Francisco, Ana Lucia Noronha. "System of fluorescence spectroscopy in the evaluation of surgical margins for squamous cell carcinoma of the oral cavity in moments in situ and ex vivo = Sistema de espectroscopia de fluorescência na avaliação de margens cirúrgicas de carcinoma de células escamonas da cavidade oral nos momentos in situ e ex vivo." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289799.

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Orientadores: Luiz Paulo Kowalski, Cristina Kurachi
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O tratamento mais empregado para os carcinomas de células escamosas da boca é a ressecção cirúrgica, sendo ou não acompanhada de radio e/ou quimioterapia. O tratamento é simplificado, diminuindo número de recidivas e aumentando a sobrevida, quando as lesões encontram-se em estágios iniciais, conforme localização anatômica e diagnóstico de margens cirúrgicas livres. Frente a isto, o desenvolvimento e aperfeiçoamento de técnicas para um diagnóstico precoce, assim como de uma acurada definição das margens cirúrgicas livres e correta delimitação da extensão do câncer boca, com o intuito de melhorar a qualidade de vida e a taxa de sobrevida desses pacientes, tornam-se de grande importância. A espectroscopia de fluorescência é uma ferramenta diagnóstica não invasiva que pode auxiliar na detecção do câncer em tempo real, com o potencial de fornecer sensibilidade e especificidade semelhantes ao diagnóstico clínico de profissionais experientes. É uma técnica relativamente simples, rápida e acurada que consiste em avaliar a composição bioquímica e a estrutura do tecido pelo espectro de fluorescência emitido por ele, após aplicação de um feixe de luz. Quando há progressão de um estado normal para um estado alterado, isso é refletido nas características espectrais da fluorescência dos tecidos, podendo ser correlacionada com o exame histopatológico destes tecidos. O objetivo do presente estudo consistiu em discriminar, na mucosa bucal, tecido sadio de neoplásico, por meio de espectroscopia de fluorescência avaliando as margens ressecadas cirurgicamente. As avaliações ocorreram nos pacientes do Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia do AC Camargo Câncer Center. O estudo obteve aprovação dos Comitês de Ética em Pesquisa das instituições participantes. A amostra consistiu de 75 indivíduos nos quais se realizou a espectroscopia de fluorescência dos quais 45 pacientes eram portadores de carcinoma oral e 30 voluntários com mucosa oral clinicamente normal. 29 casos (64.4%) do sexo masculino e a média de idade foi de 61.3 anos. Foram realizadas biópsias e os resultados destas duas metodologias foram comparados, usando o diagnóstico histopatológico como padrão ouro, para identificar características espectrais de entre tecidos clinicamente não alterados das margens cirúrgicas da mucosa de voluntários. Os espectros foram classificados e comparados com a histopatologia para determinação da eficiência na discriminação diagnóstica empregando-se a fluorescência. A análise inicial foi qualitativa e após consistiu de processamentos matemáticos dos espectros com excitação nos comprimentos de 532 e 406nm. Observou-se a variabilidade entre os indivíduos, entre os sítios anatômicos, entre regiões da mesma lesão e entre tecido clinicamente normal de voluntários e tecido das margens cirúrgicas em momentos in situ. Foram observadas também grandes diferenças entre espectros in situ e ex vivo, em concordância com resultados de outros estudos. A acurácia da técnica variou em função do tipo de análise empregada, mas pode-se constatar o seu potencial de uso como instrumento auxiliar para avaliar margens cirúrgicas no câncer de boca
Abstract: The most widely used treatment for squamous cell carcinoma of the mouth is surgical resection, whether or not accompanied by radiation and/or chemotherapy. The treatment is simplified, reducing the number of recurrences and increasing survival when the lesions are in the early stages, according to anatomical site and diagnosis of disease-free surgical margins. The development and improvement of techniques for early diagnosis, as well as an accurate definition of disease-free surgical margins and correct delineation of the extent of the mouth cancer, is an important part of improving the quality of life and survival rate for these patients. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection, with the potential to provide similar sensitivity and specificity to that of the clinical diagnoses of experienced professionals. It is a relatively simple, fast and accurate technique that assesses the biochemical composition and structure of the tissue by the fluorescence spectrum emitted after the application of a beam of light. When there is progression from a normal state to an altered state, this is reflected in the spectral characteristics of the fluorescence of the tissues, which may be correlated with the histopathological examination of these tissues. The aim of this study was to discriminate, in oral mucosa, healthy tissue through fluorescence spectroscopy by evaluating surgically resected margins. Assessments occurred in patients of the Head and Neck Surgery and Otorhinolaryngology Department of A.C. Camargo Cancer Center. The study was approved by the Research Ethics Committee of the institution. The sample consisted of 75 individuals who underwent fluorescence spectroscopy, of which there were 45 individuals with oral carcinoma and 30 healthy volunteers with normal oral mucosa. Twenty-nine cases (64.4%) were male and the mean age was 61.3 years. Biopsies were performed and the results of these two methods were compared using histopathology as the gold standard to identify spectral characteristics from clinically unchanged tissues to surgical margins of the mucosa of volunteers. The spectra were classified and compared with histopathology for determining the efficiency of diagnostic discrimination of employing fluorescence. The initial analysis was qualitative and consisted of following mathematical processing of the spectra with excitation in lengths of 532 and 406 nm. Variability was observed among individuals, anatomical sites, regions of the same lesion and clinically normal tissue of volunteers and the tissue of surgical margins in situ. Also observed were large differences between spectra in situ and ex vivo, in agreement with results of other studies. The accuracy of the technique varied according to the type of analysis used, but its potential use is noted as an aid to evaluated surgical margins in oral cancer
Doutorado
Estomatologia
Doutora em Estomatopatologia
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Books on the topic "Treatment of squamous cell carcinoma of the oral cavity"

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Oral cancer metastasis. New York: Springer, 2010.

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Murphy, Barbara A., Lauren A. Zatarain, Anthony J. Cmelak, Steven Bayles, Ellie Dowling, Cheryl R. Billante, Sheila Ridner, et al. Palliative issues in the care of patients with cancer of the head and neck. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0145.

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Head and neck cancer (HNC) refers to tumours arising from the epithelial lining of the upper aerodigestive track, including the oral cavity, larynx, pharynx, paranasal sinuses, and salivary glands. There are 50,000 cases of HNC diagnosed annually within the United States. The majority of tumours (> 90%) are squamous cell carcinomas. Risk factors include tobacco, alcohol, and areca nuts; human papilloma virus (HPV) or Epstein-Barr virus; and mucosal irritation. Previously considered to be a disease of older adults, the epidemic of HPV-associated oropharyngeal cancers has led to a striking increase in HNC among middle-aged adults. Symptoms are usually present at the time of diagnosis and remain problematic through the terminal phase. For those patients who are cured, long-term biopsychosocial sequelae may persist for years. Thus, assessment and treatment of palliative issues is an intrinsic and vital component of care for the HNC patient.
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Myers, Jeffrey. Oral Cancer Metastasis. Springer, 2014.

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Thun, Michael J., and Neal D. Freedman. Tobacco. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0011.

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Tobacco is the leading preventable cause of cancer and other non-communicable diseases worldwide. IARC and the U.S. Surgeon General designate over twenty cancer sites or subsites as causally related to active cigarette smoking, including lung, oral cavity, nasal cavity and accessory sinuses, naso- oro- and hypopharynx, larynx, esophagus (squamous cell carcinoma and adenocarcinoma), stomach, pancreas, colorectum, liver, kidney (adeno- and transitional cell carcinoma), ureter, urinary bladder, uterine cervix, ovary (mucinous), and acute myeloid leukemia. Even this list may be incomplete, as it does not include sites for which the evidence is still considered limited, such as advanced prostate cancer and breast cancer. In addition to cigarettes, all other forms of smoked and conventional smokeless tobacco products, as well as involuntary exposure to tobacco smoke, cause cancer. The use of multiple tobacco products continues to complicate tobacco control, as does the recent introduction of novel products such as e-cigarettes.
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Book chapters on the topic "Treatment of squamous cell carcinoma of the oral cavity"

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Mehta, Sushma, and Moni Abraham Kuriakose. "Principles of Surgical Management of Oral Cancer." In Oral and Maxillofacial Surgery for the Clinician, 1869–91. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_82.

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AbstractOral Cavity Squamous Cell Carcinoma (OSCC), is a heterogenous disease with respect to risk factors, geographic predelictions, treatment response and outcome. Although non-surgical treatment is employed in other head and neck sub-sites, surgery is the primary treatment modality to treat oral cancers followed by adjuvant treatment either in the form of radiation or chemoradiation based on the risk features on final histopathology. It is utmost importance that all the patients before undergo treatment are discussed and treatment plan is formulated in a multidisciplinary tumor board. This chapter intent to elaborate the basic surgical principles involved in management of different sub-sites of oral cavity as well as reconstruction of the defects.
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Abele, R., W. Lehmann, G. Pipard, and P. Alberto. "Combined-Modality Treatment with Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Oral Cavity and Oropharynx." In Perioperative Chemotherapy, 142–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-82432-6_19.

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Vermorken, Jan B. "Where and when to Use Induction Chemotherapy in Head and Neck Squamous Cell Cancer." In Critical Issues in Head and Neck Oncology, 155–79. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_11.

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AbstractThe treatment of locoregionally advanced squamous cell carcinoma of the head and neck (LA-HNSCC) is reviewed, highlighting the milestones in systemic therapy in that setting, with focus on the role of induction chemotherapy (ICT). The road to what is now considered the standard ICT regimen, i.e. the TPF (docetaxel/cisplatin/5-FU) regimen is described, and the differences between the European and the American TPF are discussed. The article describes the respective roles of ICT for larynx preservation, for treatment intensification, its role in patients with borderline resectable or unresectable oral cavity cancer, its role as a selection tool for radiotherapy dose de-escalation in patients with oropharyngeal squamous cell cancer (OPSCC) and its potential future role in strategies aiming at synchronous oligometastatic disease.ICT has an established role for organ preservation in advanced laryngeal and hypopharyngeal cancer and the TPF regimen has been validated in that setting. This approach is presently being compared in a randomized controlled trial to concurrent chemoradiotherapy (CCRT), which in many parts of the world is considered the standard organ preservation procedure. There remains uncertainty about the benefit of the sequential approach of ICT followed by CCRT, despite the fact that ICT significantly reduces the occurrence of distant metastases. It is advised that future studies should include patients who have the highest risk to develop distant metastases, in particular patients with low neck nodes and matted nodes. Moreover, further studies in patients with HPV-associated OPSCC at risk for distant failure (T4 or N3 disease) should be considered for that also. These approaches still need to be confirmed in adequately sized randomized controlled trials. Outside clinical trials, the utility of ICT is restricted to uniquely pragmatic clinical scenarios, such as unavoidable delay in radiation or in the situation that RT is not tolerated or feasible. This can happen when there is severe pain from advanced disease or there is impending airway compromise or neurologic dysfunction that necessitates rapid initiation of treatment. In all those circumstances whether within the context of trials or outside trials, it is imperative that the present backbone of ICT, the TPF regimen, is being administered by experienced oncologists, familiar with the necessary protocols and supportive care requirements to ensure patient safety and maximize adherence throughout the treatment.Future areas of research are the role of ICT in strategies whereby ICT is combined with upfront metastases-directed treatments and the usefulness of targeted agents or immune checkpoint inhibitors in the induction setting. Studies in that direction have already started. Finally, the application of radiographic, proteomic and genomic biomarkers will get attention to further define prognostic groups and guide treatment selection with greater precision.
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Agbetoba, Abib A., and Brett A. Miles. "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma." In ENT Board Prep, 235–46. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8354-0_21.

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Deshmukh, Vijay, and Kishore Shekar. "Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning." In Oral and Maxillofacial Surgery for the Clinician, 1853–67. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_81.

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AbstractThe incidence of Oral Squamous Cell Carcinoma (OSCC) is on the rise. Association with tobacco and alcohol is well established. Transformation rates in premalignant lesions and conditions vary in the available literature. Oral cancer in other parts of the world has different etiology in contrast to Indian oral cancer. Because of this Indian OSCC may require different parameters for treatment than that of the other oral cancer. Its prognosis also may not be comparable to others.
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Bier, J. "Radical Neck Dissection Versus Conservative Neck Dissection for Squamous Cell Carcinoma of the Oral Cavity." In Carcinoma of the Oral Cavity and Oropharynx, 57–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_7.

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Wolf, G. T., S. Urba, and M. Hazuka. "Induction Chemotherapy for Organ Preservation in Advanced Squamous Cell Carcinoma of the Oral Cavity and Oropharynx." In Carcinoma of the Oral Cavity and Oropharynx, 133–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_15.

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Ross Kerr, A. "Diagnostic Adjuncts for Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders." In Textbook of Oral Cancer, 99–117. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-32316-5_9.

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Boysen, M. "Value of Follow-Up in Patients Treated for Squamous Cell Carcinomas of the Oral Cavity and Oropharynx." In Carcinoma of the Oral Cavity and Oropharynx, 205–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_23.

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Mazeron, J. J., L. Grimard, and V. Benk. "Curietherapy Versus External Irradiation Combined with Curietherapy in Stage II Squamous Cell Carcinomas of Mobile Tongue and Floor of Mouth." In Carcinoma of the Oral Cavity and Oropharynx, 101–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_12.

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Conference papers on the topic "Treatment of squamous cell carcinoma of the oral cavity"

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Won, Hye Sung, Ji Hyung Hong, Eun Kyoung Jeon, Yoon Ho Ko, Sang Hoon Chun, Chan-Kwon Jung, and Jin-Hyoung Kang. "Abstract B21: The difference in the role of PI3K/Akt/mTOR pathway between oropharyngeal squamous cell carcinoma and oral cavity squamous cell carcinoma." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-b21.

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Hsieh, Ling-Ling, Chih-Hsiung Lai, Shiang-Fu Huang, Chun-Ta Liao, I.-How Chen, and Hung-Ming Wang. "Abstract 2009: Clinical value of pathogenic mitochondrial mutations in oral cavity squamous cell carcinoma." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2009.

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Hsueh, Pei Chun, and Chih Ching Wu. "Abstract 1148: Salivary auto-antibodies as diagnostic markers of oral cavity squamous cell carcinoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1148.

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Hu, Yaogai, Tao Jiang, and Zhengyu Zhao. "Discrimination of Squamous Cell Carcinoma of the Oral Cavity Using Raman Spectroscopy and Chemometric Analysis." In 2008 First International Conference on Intelligent Networks and Intelligent Systems (ICINIS). IEEE, 2008. http://dx.doi.org/10.1109/icinis.2008.61.

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Campbell, Katie M., Tianxiang Lin, Ashley E. Winkler, Paul Zolkind, Zachary L. Skidmore, Erica K. Barnell, Ian Hagemann, et al. "Abstract 3847: Oral cavity squamous cell carcinoma xenografts display conservation of primary tumor genomic heterogeneity." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3847.

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Goda, Hiroyuki, Koh-ichi Nakashiro, and Hiroyuki Hamakawa. "Abstract 4505: Akt1 is a potent molecular target for treatment of oral squamous cell carcinoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4505.

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Hu, Yaogai, Zhengyu Zhao, and Tao Jiang. "Classification of Squamous Cell Carcinoma of the Oral Cavity Using Wavelet Analysis and BP-Chaos Networks." In 2009 First International Conference on Information Science and Engineering. IEEE, 2009. http://dx.doi.org/10.1109/icise.2009.393.

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Chang, Kai-Ping, Ting-Wen Chen, Curtis R. Pickering, Jeffrey N. Myers, and Yu-Sun Chang. "Abstract IA10: Integrated omics analyses identify prognostic biomarkers of oral cavity squamous cell carcinoma in Taiwan." In Abstracts: AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.aacrahns17-ia10.

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Hu, Yaogai, Zhengyu Zhao, and Tao Jiang. "Discrimination of Squamous Cell Carcinoma of the Oral Cavity Using Confocal Raman Microspectroscopy and BP-Chaos Networks." In 2009 International Conference on Computational Intelligence and Software Engineering. IEEE, 2009. http://dx.doi.org/10.1109/cise.2009.5366214.

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Lim, Kue Peng, Chai Phei Gan, Chan Eng Chong, Rosnah Binti Zain, Mannil Thomas Abraham, Zainal Ariff Abdul Rahman, Soo-Hwang Teo, et al. "Abstract 1573: MAGED4B drives oral carcinogenesis and is a promising peptide vaccine target for the treatment of oral squamous cell carcinoma." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1573.

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