Journal articles: 'Treatment of squamous cell carcinoma of the oral cavity'

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Hoffman, Henry T., Gerry F. Funk, Timothy M. McCulloch, and Scon Graham. "Cost Analysis of Treatment of Oral Cavity Squamous Cell Carcinoma." Otolaryngology–Head and Neck Surgery 113, no. 2 (August 1995): P50. http://dx.doi.org/10.1016/s0194-5998(05)80575-3.

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Patni, Parth, Deepak Dalmia, Narsinha Davange, Karthika Bhagavan, Amit Palwade, and Rizul Goyal. "Level IIb involvement in oral cavity squamous cell carcinoma." International Journal of Otorhinolaryngology and Head and Neck Surgery 7, no. 2 (January 25, 2021): 292. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20210159.

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Background: Cervical lymph node status is the most significant prognostic factor in the treatment of patients with OSCC. Adequate clearance of level IIb lymph nodes require traction and elevation of the spinal accessory nerve (SAN) and can lead to consequent shoulder problems.Therefore, avoiding the dissection of level IIb has been increasingly proposed to overcome this complication. The aim of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs).Methods: A total of 106 newly diagnosed oral cavity cancer patients requiring surgery as the primary modality were included in the study. Preoperative clinical examinations were done and tumor-node-metastasis staging was noted. Intraoperative, level IIb nodal tissue was dissected and sent separately.Results: A total of 106 neck dissections were done out of which male: female ratio of 2.78:1. 49.05% patients were suffering from buccal mucosa carcinoma followed by tongue carcinoma (22.64%). 52.83% of patients had no neck involvement. Among neck positive cases, pN1 was the most common presentation. Out of these, only 8 (7.54%) neck dissections had level IIb positive.Conclusions: Dissection of the level IIb region in patients with OSCC may be required only in cases with advanced N stage, positive level IIa lymph nodes, and extra capsular spread. Further evaluation can be done among various subsites of OSCC, clinical staging of tumour, occult bilateral nodal metastasis to assess the need of resection of level IIb in OSCC.

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Su, Nai-Wen, and Yu-Jen Chen. "Metronomic Therapy in Oral Squamous Cell Carcinoma." Journal of Clinical Medicine 10, no. 13 (June 26, 2021): 2818. http://dx.doi.org/10.3390/jcm10132818.

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Metronomic therapy is characterized by drug administration in a low-dose, repeated, and regular manner without prolonged drug-free interval. The two main anticancer mechanisms of metronomic therapy are antiangiogenesis and immunomodulation, which have been demonstrated in several delicate in vitro and in vivo experiments. In contrast to the traditional maximum tolerated dose (MTD) dosing of chemotherapy, metronomic therapy possesses comparative efficacy but greatlydecreases the incidence and severity of treatment side-effects. Clinical trials of metronomic anticancer treatment have revealed promising results in a variety cancer types and specific patient populations such as the elderly and pediatric malignancies. Oral cavity squamous cell carcinoma (OCSCC) is an important health issue in many areas around the world. Long-term survival is about 50% in locally advanced disease despite having high-intensity treatment combined surgery, radiotherapy, and chemotherapy. In this article, we review and summarize the essence of metronomic therapy and focus on its applications in OCSCC treatment.

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Patil, Seema, Manmita Das, Asha R. Iyengar, Subash B.V, Ritika Agarwal, and Aparna S. Namboothiri. "GINGIVAL SQUAMOUS CELL CARCINOMA- A CASE REPORT." International Journal of Advanced Research 8, no. 11 (November 30, 2020): 548–53. http://dx.doi.org/10.21474/ijar01/12040.

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Gingival squamous cell carcinoma (GSCC) is a relatively rare malignant neoplasm of the oral cavity. It represents less than 4-6.3% of diagnosed intraoral carcinomas. GSCC may cause odontogenic symptoms such as mobility and pain of teeth mimicking inflammatory conditions such as periodontitis. Early diagnosis and prompt management of GSCC is of paramount importance as the prognosis of gingival squamous cell carcinoma is mainly dependent on these factors. Further, as, GSCCs spread rapidly to involve the underlying bone, the role of dentists in early detection of gingival squamous cell carcinoma cannot be undermined. The present report describes a rare case of GSCC in a 31 year old male. The detailed recording of the case history and clinical examination, radiographic, and laboratory investigations, along with review of similar conditions led to the diagnosis, and treatment was initiated.

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Israyani, Israyani, Ayu F. Argadianti, Hening Tuti Hendarti, and Adiastuti E. P. "Managementof squamos cell carcinoma of tongue in young men: case report." Journal of Case Reports in Dental Medicine 1, no. 1 (May 1, 2019): 21. http://dx.doi.org/10.20956/jcrdm.v1i1.95.

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Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap

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Palme, Carsten E., Patrick J. Gullane, and Ralph W. Gilbert. "Current treatment options in squamous cell carcinoma of the oral cavity." Surgical Oncology Clinics of North America 13, no. 1 (January 2004): 47–70. http://dx.doi.org/10.1016/s1055-3207(03)00123-6.

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Ye, Gang, Gary V. Burton, Cherie-Ann O. Nathan, and Federico L. Ampil. "Squamous Cell Carcinoma of the Oral Cavity Following Breast Cancer Treatment." Southern Medical Journal 99, no. 10 (October 2006): 1150–51. http://dx.doi.org/10.1097/01.smj.0000240721.53724.98.

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Schwartz, Glenn J., Rajeev H. Mehta, Barry L. Wenig, Chitra Shaligram, and Louis G. Portugal. "Salvage treatment for recurrent squamous cell carcinoma of the oral cavity." Head & Neck 22, no. 1 (January 2000): 34–41. http://dx.doi.org/10.1002/(sici)1097-0347(200001)22:1<34::aid-hed6>3.0.co;2-3.

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CS, Ng, Mohd Razif M. Y, Chew MX, and Suria HMP. "Spindle Cell Carcinoma of Oral Cavity: A Rare Entity." Bangladesh Journal of Medical Science 20, no. 4 (June 18, 2021): 923–25. http://dx.doi.org/10.3329/bjms.v20i4.54154.

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Introduction:Spindle cell carcinomas (SpCC) are a rare variant of squamous cell carcinoma which is rarely encountered in the head and neck. It is also known as“pseudocarcinoma”, “sarcomatoidcarcinoma,” and “carcinosarcoma”.It has an aggressive nature and has poor prognosis despite aggressive treatment. Case report: A 48-year-old lady presented to us with a right painless upper gum swelling which was progressively enlarging for 3 months after tooth extraction. Examination of the oral a fungating mass over the right upper alveolus extending to the right upper gingivolabial sulcus. She was subjected to a debulking palliative to reduce the tumour bulk. The intraoperative samples sent for histopathological examination was reported as SpCC, AJCC (8th edition) stage pT2pN3b. She recovered well after the surgery with quality of life after the surgery. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.923-925

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Sultana, N., Q. B. Rahman, S. Alam, Md M. Karim, and Md F. Kabir. "Effect of Neoadjuvant Chemotherapy on the Size of Lesion in Oral Squamous Cell Carcinoma." Journal of Medical Science & Research 21, Number 2 (July 1, 2013): 9–17. http://dx.doi.org/10.47648/jmsr.2013.v2102.02.

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A prospective randomized trial was performed to evaluate the combination of neoadjuvant chemotherapy in patient with oral squamous cell carcinoma. Prognosis of patient with squamous cell carcinoma in oral cavity is worth improving. Chemotherapy has been reported specially active in oral cavity tumour. It has been enrolling patients with stage T2, T3, T4 NO NI N2 MO untreated squamous cell carcinoma in oral cavity. Number of patients in this study was 25, suffering from squamous cell carcinoma. This study was a Prospective study conducted among the randomly selected 25 cases of histopathologically diagnosed Squamous cell carcinoma patients from the Department of Oral and Maxillofacial surgery Bangabandhu Sheikh Mujib Medical University and Department of Oncology Bangabandhu Shiekh Mujib Medical university . Both male and female were included and assigned for three cycles of cisplatin and 5fluorouracil followed by definitive treatment. The study was done between January 2007 to December 2008. 25 patients were included in this study, 21.7% patients showed complete response and 84.2% showed partial response. Out of 25, 20.0% patients mouth opening were reduced and 4.0% patients mouth opening were improved. After taking computed tomography all patient showed tumour progression. Histopathologically only 1 patient showed complete response among 25 which is not signcant. Neoadjuvant chemotherapy reduced the size of the lesion clinically. Results down staging of the tumour but histologically it was not given any significant changes. So probably neoadjuvant chemotherapy is unable to fulfill our desire expectation.

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McHugh, Jonathan B. "Association of Cystic Neck Metastases and Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma." Archives of Pathology & Laboratory Medicine 133, no. 11 (November 1, 2009): 1798–803. http://dx.doi.org/10.5858/133.11.1798.

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Abstract Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus–associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumors occur in younger patients and are more often seen in nonsmokers compared with conventional oral cavity and oropharyngeal squamous cell carcinomas. The incidence of human papillomavirus–associated squamous cell carcinoma is increasing. Recognition of this unique clinicopathologic subset of head and neck carcinoma is important because these patients typically respond more favorably to organ-sparing treatment modalities and have an improved prognosis.

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Lakshmaiah, K. C., T. M. Suresh, K. Govind Babu, Nagesh T. Sirsath, Lokanatha Dasappa, and Linu Jacob Abraham. "Locally advanced oral cavity squamous cell carcinoma: Barriers related to effective treatment." South Asian Journal of Cancer 04, no. 02 (April 2015): 061–64. http://dx.doi.org/10.4103/2278-330x.155637.

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Abstract Background: Oral cavity cancer is a significant health problem in India. Majority of patients present with locally advanced disease requiring multimodality treatment. Compliance to recommended treatment is an important factor affecting outcome. Aims: The aim was to evaluate the outcome of locally advanced oral cavity cancer patients with regards to treatment adherence and to assess reasons of noncompliance. Materials and Methods: This was a prospective observational study. We included patients referred to Department of Medical Oncology for induction chemotherapy in view of locally advanced oral cavity cancer. Results: Only 15 (26%) patients completed planned treatment schedule. Their 1 year overall survival was 93%. The remaining 43 patients who received inadequate treatment had a dismal 21% 1 year overall survival. Illiteracy, poverty, long waiting list for surgery, prolonged delay for health scheme treatment plan approval and dissatisfaction with attitude of hospital staffs are major barriers related to effective treatment of these patients. Conclusions: A detailed discussion with patient and their relatives regarding recommended treatment, proper implementation of health schemes, increasing trained manpower to avoid long waiting list for surgery, provision of additional financial support for family member accompanying the patient and a sympathetic approach toward patients are needed to help these patients overcome the battle.

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Li, Wei, Cheng Tao, Jiexin Wang, Yuan Le, and Jianjun Zhang. "MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma." RSC Advances 9, no. 54 (2019): 31264–73. http://dx.doi.org/10.1039/c9ra04343h.

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Chen, H., A. M. Mudunov, R. I. Azizian, I. N. Pustynskiy, O. A. Saprina, and M. V. Bolotin. "Free radial forearm flap for reconstruction of postoperative defects in combined and complex treatment of patients with locally-advanced squamous cell carcinoma of the oral cavity." Head and Neck Tumors (HNT) 10, no. 1 (April 11, 2020): 55–64. http://dx.doi.org/10.17650/2222-1468-2020-10-1-55-64.

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The study objective is to assess immediate and long-term results of replacing complex defects with a free radial forearm flap in the multimodal treatment of patients with locally advanced oral cavity squamous cell carcinoma. Materials and methods. Twenty eight patients (20 women and 8 men aged 23 to 71 years) with locally advanced oral cavity squamous cell carcinoma (including 10 buccal cancers, 8 carcinomas of tongue, 6 carcinomas of the floor of the mouth, 2 retromolar area carcinomas, 1 carcinoma of the hard palate and 1 carcinoma of alveolar region of the lower jaw) underwent tumor surgery with simultaneous plastic reconstruction of the defect using radial forearm free flap at the department of head and neck tumors of N. N. Blokhin National Medical Research Center of Oncology within 2010–2018. Primary tumors were detected in 2 patients and 11 patients had residual (n = 7) or recurrent (n = 4) tumors after radiotherapy or chemoradiotherapy. Results. An overall success rate was 96.4 %. Postoperative histology revealed that there were no tumor cells at the resection edges. Postoperative complications included: complete flap necrosis in 1 patient with severe concomitant diseases, marginal flap necrosis in 2 patients (in both cases after the necrotic tissue had rejected, wounds were healed by secondary intention), sural veins thrombosis in 1 patient, acute peptic ulcer bleeding on the 6th day after surgery in 1 patient treated with emergency endoscopic hemostasis. No lethal outcomes were reported. Postoperative period lasted in average 14 days. Upon subsequent observation tumor relapse in the oral cavity occurred in 4 (14.3 %) patients, relapses of regional metastases – in 2 (7.1 %). Good aesthetic and functional results were noted. Adequate restoration of breathing, chewing, swallowing and speaking resulted in a full patients’ rehabilitation. In all cases, the radial flap adapted well to the oral cavity organs and corresponded to the surrounding tissues in thickness and consistency. Conclusion. Use of a radial forearm free flap makes it possible to successfully reconstruct extensive and complex defects after surgery of locally advanced primary and recurrent forms of oral cavity squamous cell cancer of various locations. Due to flap’s high regenerative capabilities, preoperative radiation therapy does not affect the frequency of local complications. It allows restoring vital functions of the oral cavity and achieving good aesthetic and functional results.

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Chijiwa, H., K. Sakamoto, H. Umeno, T. Nakashima, G. Suzuki, and N. Hayafuchi. "Minor salivary gland carcinomas of oral cavity and oropharynx." Journal of Laryngology & Otology 123, S31 (May 2009): 52–57. http://dx.doi.org/10.1017/s002221510900509x.

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AbstractThis paper reviews 22 cases of minor salivary gland carcinoma of the oral cavity or oropharynx which were treated at Kurume University Hospital between 1976 and 2005. Minor salivary gland carcinoma was observed in eight of 362 patients with cancer of the oral cavity (2 per cent), and in 14 of 275 patients with cancer of the oropharynx (5 per cent). The five-year and 10-year survival rates of patients with oropharyngeal minor salivary gland carcinoma were 90 per cent. No statistically significant difference was observed between survival rates for oropharyngeal minor salivary gland carcinoma and for oropharyngeal squamous cell carcinoma (p = 0.06). The five- and 10-year survival rates of patients with oral cavity minor salivary gland carcinoma were 75 and 37 per cent, respectively. No statistically significant difference was observed between survival rates for oral cavity minor salivary gland carcinoma and oral cavity squamous cell carcinoma.Patients' survival results correlated well with the clinical stage of their lesions. A significant difference in survival was observed, comparing stage IV with stages I, II and III (p = 0.04). In contrast, no significant relationship was found between either survival and tumour type or survival and treatment. Adjuvant therapy is recommended for patients with grade III adenoid cystic carcinoma with perineural infiltration or intravascular infiltration.

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Mudunov, А. М., B. I. Dolgushin, А. А. Аkhundov, М. N. Narimanov, D. А. Safarov, I. А. Тrofimov, and B. G. Pkheshkhova. "Regional intra-arterial polychemotherapy to increase the effectiveness of conservative treatment of locally invasive oral squamous cell carcinoma." Head and Neck Tumors (HNT) 9, no. 3 (October 31, 2019): 24–28. http://dx.doi.org/10.17650/2222-1468-2019-9-3-24-28.

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The objective is using a clinical example to demonstrate the possibilities of intra-arterial polychemotherapy (PCT) in the combined treatment of oral squamous cell carcinoma.Clinical case. A 43-year-old oral squamous cell carcinoma patient with metastases to cervical lymph nodes, left side (T3N2bM0, stage IV) underwent 2 courses of regional neoadjuvant intra-arterial PCT (docetaxel at a dose of 105 mg, cisplatin at a dose of 105 mg), accessed through a. lingualis. A total dose of 6,800 mg of 5-fluorouracil was administered as a 96-hour infusion. PCT induced oral mucositis of grade 2, no hematological side effects were observed. Clinical examination revealed that tumor volume decreased by 60 %. Ultrasound detected no changes in lymph nodes. Second step included resection of oral cavity bottom tissues, atypical tongue resection, marginal resection of the lower jaw on the left, radical neck dissection on the left. Histological study of the surgical material of primary tumor region as well as metastases of the cervical lymph nodes on the tumor side revealed pathomorphism of 4 grade. In the postoperative period, oral cavity and neck were irradiated from 2 sides. No signs of the disease were detected within 9 months after the combined treatment.Conclusion. The clinical case demonstrates the high efficiency of regional intra-arterial PCT in patients with locally invasive oral squamous cell carcinoma. It seems relevant to further study its possibilities in the combined treatment of locally invasive forms of oral squamous cell carcinoma.

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Liao, Ying-Ting, Hung-Ding Tseng, Peter Chang, Pen-Yuan Chu, Ying-Ju Kuo, and Chun-Yu Liu. "Second Primary Spindle Cell Carcinoma of Oral Cavity and Oropharynx: A Case Report and Literature Review." Reports 1, no. 2 (September 12, 2018): 16. http://dx.doi.org/10.3390/reports1020016.

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Spindle cell squamous cell carcinoma (SpCC) is a poorly differentiated subtype of squamous cell carcinoma (SqCC). We report a case with second primary oropharyngeal SpCC after seven years of complete treatment of SqCC. The patient underwent surgery and adjuvant chemoradiotherapy. Relevant literature about SpCC was reviewed.

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Burns, P., A. Foster, P. Walshe, and T. O'Dwyer. "Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx." Journal of Laryngology & Otology 123, no. 4 (September 17, 2008): 439–43. http://dx.doi.org/10.1017/s0022215108003514.

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AbstractObjectives:Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma.Design:We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative.Results:A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease.Conclusion:In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.

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Horton, Joshua Dean, Hannah Knochelmann, Kent Armeson, John M. Kaczmar, Chrystal Paulos, and David Neskey. "Neoadjuvant presurgical PD-1 inhibition in oral cavity squamous cell carcinoma." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 2574. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.2574.

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2574 Background: Oral cavity squamous cell carcinoma (OCSCC) is a highly prevalent surgically-treated subset of head and neck cancer with frequent recurrence and poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic head and neck cancer, but has not been validated in the neoadjuvant presurgical setting. Methods: A Simon two stage design was used in this single-arm, Phase II clinical trial with a preplanned analysis after completion of stage one. The first stage included 9 patients with stage II-IVA OCSCC who received 3-4 biweekly doses of 3mg/kg Nivolumab (anti-programmed death 1 [PD-1]) followed by definitive surgical resection for cure. The primary endpoint was overall response rate to treatment. Secondary endpoints were safety and feasibility. Results: Presurgical Nivolumab therapy resulted in an overall response rate of 44% (95% CI: 14-79%) with four patients having >30% reduction in tumor size consistent with partial response. An additional patient had stable disease while the remaining four patients progressed through treatment. Neoadjuvant Nivolumab was not associated with delays in definitive surgical treatment. There were no grade 3-4 adverse events and no treatment interruptions. At median follow up of 10 months (2-16), there were 4 recurrences in 3 patients and one death. Objective response by RECIST 1.1 criteria on interval imaging predicated eventual pathologic response in 100% of patients. Conclusions: Neoadjuvant presurgical PD-1 blockade is associated with encouraging response rate and demonstrates feasibility and safety for OCSCC. Clinical trial information: NCT03021993.

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Yang, S. F., W. E. Yang, H. R. Chang, S. C. Chu, and Y. S. Hsieh. "Luteolin Induces Apoptosis in Oral Squamous Cancer Cells." Journal of Dental Research 87, no. 4 (April 2008): 401–6. http://dx.doi.org/10.1177/154405910808700413.

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Oral squamous cell carcinoma is the most common malignancy of the oral cavity, and treatment approaches are inadequate. Luteolin, a natural flavonoid compound, has been shown to have anti-tumorigenic properties on various types of tumors. Therefore, we hypothesized that luteolin has anti-tumorigenic properties for oral squamous cell carcinoma, and may provide effective chemotherapy. Results revealed that luteolin reduced the viability of SCC-4 cells and induced apoptosis by decreasing the expression of cyclin-dependent kinase (CDKs), cyclins, and phosphor- retinoblastoma (p-Rb) anti-apoptotic protein, but increased the expression of pro-apoptotic proteins and activated caspase 9 and 3, with a concomitant increase in the levels of cleaved poly-ADP-ribose polymerase (PARP). Combination treatment of luteolin with paclitaxel enhanced the cytotoxic effect of paclitaxel in SCC-4 cells, and continuous administration of luteolin suppressed the growth of xenograft tumors in nude mice. These results suggest that luteolin could be an effective chemotherapeutic agent for the treatment of oral squamous cell carcinoma.

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Lien, Kuang-Hsu, Paula Francezca C. Padua, Ze Yun Tay, Huang-Kai Kao, Shao-Yu Hung, Yenlin Huang, Ngan-Ming Tsang, and Kai-Ping Chang. "Influence of Hyperglycemia on Treatment Outcomes of Oral Cavity Squamous Cell Carcinoma." Journal of Oral and Maxillofacial Surgery 78, no. 6 (June 2020): 935–42. http://dx.doi.org/10.1016/j.joms.2020.01.018.

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Koo, Bon Seok, Young Chang Lim, Jin Seok Lee, and Eun Chang Choi. "Recurrence and salvage treatment of squamous cell carcinoma of the oral cavity." Oral Oncology 42, no. 8 (September 2006): 789–94. http://dx.doi.org/10.1016/j.oraloncology.2005.11.016.

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Janus, Seth C., Beverly Weurtz, and Frank G. Ondrey. "Inositol Hexaphosphate and Paclitaxel: Symbiotic Treatment of Oral Cavity Squamous Cell Carcinoma." Laryngoscope 117, no. 8 (August 2007): 1381–88. http://dx.doi.org/10.1097/mlg.0b013e3180679e59.

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Fujiwara, Rance J. T., Benjamin L. Judson, Wendell G. Yarbrough, Zain Husain, and Saral Mehra. "Treatment delays in oral cavity squamous cell carcinoma and association with survival." Head & Neck 39, no. 4 (February 25, 2017): 639–46. http://dx.doi.org/10.1002/hed.24608.

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Inagi, Katsuhide, Hiroomi Takahashi, M. Akito Okamoto, Meijin Nakayama, Tomohiro Makoshi, and Hiromi Nagai. "Treatment Effects in Patients with Squamous Cell Carcinoma of the Oral Cavity." Acta Oto-Laryngologica 122, no. 4 (January 2002): 25–29. http://dx.doi.org/10.1080/000164802760057527.

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Zhang, Zi, Justin C. Brown, Bert W. O’Malley, Andrea B. Troxel, Joshua M. Bauml, Kaitlyn R. Rubnitz, Colleen M. Grosso, Gregory S. Weinstein, and Kathryn H. Schmitz. "Post-treatment weight change in oral cavity and oropharyngeal squamous cell carcinoma." Supportive Care in Cancer 24, no. 5 (December 1, 2015): 2333–40. http://dx.doi.org/10.1007/s00520-015-3029-6.

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Bubliy, T. D., L. I. Voloshina, and L. I. Dubovaya. "EFFECT OF QUARANTINE ON THE RATE OF DIAGNOSTICS OF ORAL SQUAMOUS CELL CARCINOMA." Ukrainian Dental Almanac, no. 2 (June 29, 2021): 11–14. http://dx.doi.org/10.31718/2409-0255.2.2021.02.

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Oral squamous cell carcinoma is the most prevalent manifestations of malignant tumors in the cranial and cervical regions and they cannot be frequently established until symptoms appear. So there is an urgent need to device methods for the detection of oral premalignant lesions and oral cancer at an early stage in order to improve further patients’ conditions. The whole world was suddenly affected the uncontrolled spread of the coronavirus. All spheres of life were affected, especially medicine. The strict quarantine for 2 months created problems for the patients. Patients who needed dental care they also suffered from it. Dental medical institutions provided only emergency medical care during the period of quarantine restrictions. The planned treatment was postponed until the quarantine restrictions stopped. In fact, the entire population of the country was in a state of significant psycho-emotional stress. This was combined with the state of chronic stress, and influenced the number of cancers. This trend can be traced worldwide. According to the literature, in the United States, squamous cell carcinoma of the oral cavity takes 3% of all cancers in men and 2% in women. The tendency of this disease in people 50 years older observed all over the world, however, the disease occurs in people aged 32-49 years. About 40% of intraoral squamous cell carcinomas begin on the floor of the mouth or on the lateral and ventral surfaces of the tongue. About 38% of all oral squamous cell carcinomas occur on the lower lip; these are usually solar-related cancers on the external surface. The symptoms of this disease in the initial stages are absolutely nonspecific. Many patients do not attach importance to them. Quarantine restrictions on the provision of advisory assistance make this problem of particular relevance. The authors of the article have determined that their goal to attract the attention of dentists and family doctors to the problem of early diagnosis of oncological diseases and oral cancer is enough important nowadays. Early, curable lesions are rarely symptomatic; thus, preventing fatal disease requires early detection by screening. The main goal for such investigations is to attract the attention of dentists and family doctors to the problem of early diagnosis of cancer, including oral cavity. The article presents the clinical characteristics of squamous cell carcinoma of the oral cavity. Particularly, doctors should pay attention to the variety of symptoms characteristic of the initial period of the disease. Patients may complain of thickening of the tissues of the oral cavity, the presence of white spots, ulcerative lesions, which may be covered with plaque. Slight painful sensations are distinguished as manifestations of other diseases. Sometimes the symptoms are relieved by taking analgesics. Patients self-medicate and postpone visiting a specialized specialist for an indefinite time. This does not trouble both patients and some health workers. It should be noted that a typical symptom in the developed period is fetid odor from the mouth due to decay and infection of the tumor. Oral lesions are asymptomatic initially, highlighting the need for oral screening. Most dental professionals carefully examine the oral cavity and oropharynx during routine care and may do a brush biopsy of abnormal areas. The lesions may appear as areas of erythroplakia or leukoplakia and may be exophytic or ulcerated. Cancers are often indurated and firm with a rolled border. As the lesions increase in size, pain, dysarthria, and dysphagia may result. During the period of neglect, cancer of the oral cavity organs quickly spreads and destroys the surrounding tissues, infiltrates the floor of the oral cavity, palatine arches, pharynx, etc. To illustrate the problems outlined in the article, the authors took a clinical case that combines the problems of early diagnosis of oral cancers. It should be noted that in addition to the “inactivity” of the patient in solving problems that occurred in the oral cavity, the resolution of the situation was inhibited by the introduced quarantine measures.

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Patel, Evan J., Jamie R. Oliver, Alec Vaezi, Zujun Li, Michael Persky, Moses Tam, Kenneth S. Hu, Adam S. Jacobson, and Babak Givi. "Primary Surgical Treatment in Very Advanced (T4b) Oral Cavity Squamous Cell Carcinomas." Otolaryngology–Head and Neck Surgery 165, no. 3 (January 5, 2021): 431–37. http://dx.doi.org/10.1177/0194599820984358.

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Objectives To describe patterns of primary surgical treatments in patients with T4b oral cavity squamous cell carcinoma (OCSCC). Study Design Historical cohort study. Setting National Cancer Database. Methods Review of the National Cancer Database between 2004 and 2017 for all T4b OCSCCs. Only patients with curative treatment methods were included in the survival analysis. Surgical and nonsurgical outcomes were compared by multivariable and propensity score matching analysis. Results A total of 1515 cases of T4b OCSCC were identified. A minority of patients (n = 363, 24.0%) underwent curative treatment; among these, 206 (56.7%) underwent primary surgery. Median length of follow-up was 24 months. The 90-day mortality of patients who underwent surgical treatment was 1.0%. The 2-year survival was higher for patients who underwent surgery + chemoradiotherapy (CRT) as compared with CRT (64.6% vs 45.2%, P < .001). On multivariable analysis, surgery + CRT was associated with longer survival. In a propensity score–matched cohort of 312 patients, 2-year survival remained higher in the surgical group versus the nonsurgical group (59.4% vs 45.5%, P = .02). Among patients who underwent surgery + CRT, there was no difference in 2-year survival between clinical T4a and T4b (59% vs 64.6%, P = .20). Conclusions A minority of patients with T4b OCSCC undergo treatments with curative intent. A subset of patients underwent primary surgical treatment, which was associated with longer survival. The T4b classification might entail a heterogenous group, and further studies in revision of this classification might be justified.

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Lyanova, A. A., L. Yu Vladimirova, E. P. Ulianova, A. E. Storozhakova, N. A. Abramova, I. L. Popova, M. A. Teplyakova, et al. "Study of EGFR expression in tumor tissue in patients with locally advanced oral cavity cancer receiving cetuximab therapy." Meditsinskiy sovet = Medical Council, no. 9 (July 30, 2020): 182–89. http://dx.doi.org/10.21518/2079-701x-2020-9-182-189.

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Introduction: Squamous cell carcinoma of the oral cavity is one of the most common head and neck cancers with an aggressive course and high mortality rates. The aim of the study was to determine the EGFR expression levels in tumor tissues in patients with squamous cell carcinoma of the tongue and oral mucosa depending on the efficacy of the therapy. Material and methods: The study included 60 patients with squamous cell carcinoma of the tongue and oral mucosa T3-4N0-1M0. The main group included 30 patients receiving chemotherapy (cisplatin/fluorouracil) in combination with targeted therapy with cetuximab. The control group included 30 patients receiving chemotherapy without cetuximab. Both groups were divided into two subgroups: sensitive and resistant. Results: In treatment-resistant patients of the main group with cetuximab, the average EGFR expression was twice lower than the initial levels (p = 0.0080) and 1.7 times higher than in treatment-resistant patients of the control group (p = 0.0157). In treatment-sensitive patients, the average EGFR expression was 19.8 times lower (p = 0.0020) than initial values and 14.9 times higher (p = 0.0067) than in treatment-sensitive controls. Conclusions: A natural decrease in the EGFR expression in tumor tissues due to the targeted therapy was revealed. However, some patients were resistant to cetuximab, which dictates the need to search for predictors of targeted therapy efficacy in patients with locally advanced squamous cell carcinoma of the tongue and oral mucosa.

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Patel, Sundip H., Mike Yao, and Tara Brennan. "Radionecrosis after Treating Oral Cavity & Oropharyngeal SCC." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (August 2008): P43—P44. http://dx.doi.org/10.1016/j.otohns.2008.05.142.

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Objective 1) The primary goal of this study was to evaluate the incidence of radionecrosis among patients treated with radiation therapy for oral cavity & oropharynx squamous cell carcinoma at our institution. Many patients with oral cavity & oropharyngeal cancers receive radiation to preserve the tongue, knowing the risks of post-treatment radionecrosis. However, recent protocols have intensified chemo-radiotherapy in an effort to improve local control while possibly increasing risk. 2) Among those patients with radionecrosis, we also analyzed their cancer treatment regimen, associated risk factors, the severity of the radionecrosis and the resulting treatment they recieved. Methods We performed a retrospective review of all adult patients at our tertiary care facility with biopsy proven squamous cell carcinoma of the oral cavity & oropharynx from 1999 to 2007 who completed a full course of radiotherapy at our facility with at least 6 months follow-up. Medical charts were reviewed for the presence of radionecrosis as well as for other corresponding, pertinent data. Results After reviewing 241 patients, a total of 107 patients were included. 5 of 65 with oropharynx disease had radionecrosis, revealing an incidence of 7.7%. Among the oral cavity group there were 8 out of 42 patients with radionecrosis, revealing an incidence of 19%. The overall incidence among our treatment group was 12.1%. Conclusions Radiation-induced necrosis of the oral cavity & oropharynx is still a significant complication in the treatment of head and neck cancer and poses a higher risk in the oral cavity than the oropharynx.

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Gamez, Mauricio E., Ryan Kraus, Michael L. Hinni, Eric J. Moore, Daniel J. Ma, Stephen J. Ko, Jean Claude M. Rwigema, et al. "Treatment outcomes of squamous cell carcinoma of the oral cavity in young adults." Oral Oncology 87 (December 2018): 43–48. http://dx.doi.org/10.1016/j.oraloncology.2018.10.014.

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Stefani, Antonella De, Guido Valente, Guido Forni, Walter Lerda, Riccardo Ragona, and Giorgio Cortesina. "Treatment of Oral Cavity and Oropharynx Squamous Cell Carcinoma with Perilymphatic Interleukin-2." Journal of Immunotherapy 19, no. 2 (March 1996): 125–33. http://dx.doi.org/10.1097/00002371-199603000-00005.

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Gross, Neil D., Snehal G. Patel, Andre L. Carvalho, Pen-Yuan Chu, Luis P. Kowalski, Jay O. Boyle, Jatin P. Shah, and Michael W. Kattan. "Nomogram for deciding adjuvant treatment after surgery for oral cavity squamous cell carcinoma." Head & Neck 30, no. 10 (October 2008): 1352–60. http://dx.doi.org/10.1002/hed.20879.

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Gamez, M. E., R. D. Kraus, M. L. Hinni, E. J. Moore, D. J. Ma, S. Ko, J. C. Rwigema, et al. "Treatment Outcomes of Squamous Cell Carcinoma of the Oral Cavity in Young Adults." International Journal of Radiation Oncology*Biology*Physics 100, no. 5 (April 2018): 1340–41. http://dx.doi.org/10.1016/j.ijrobp.2017.12.090.

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Nurrahman, Tri, Seto Adiantoro, Kiki Akhmad Rizki, and Farah Asnely. "MULTIDISCIPLINARY APPROACH IN THE TREATMENT OF SQUAMOUS CELL CARCINOMA AT REGIO GLOSSUS." Dentino : Jurnal Kedokteran Gigi 5, no. 2 (August 15, 2020): 205. http://dx.doi.org/10.20527/dentino.v5i2.8976.

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ABSTRACTBackground: Squamous Cell Carcinoma (SCC) is the most common case of oral cancer which often occurs laterally on the tongue and rarely develops on the dorsal surface of the tongue. More than half of the cases are diagnosed late, thereby reducing the survival rate of the patients. Objective: This report was intended as an evaluation for the management of squamous cell carcinoma under multidisciplinary approach between oral surgery and other departments, as well as the provision of further post-operative treatment. Case Report: The author presents a case of 68-years-old female patient with a lump and an ulcer on her tongue. Around six months prior to the visit, patient complained of tongue ulcer followed by the emergence of a lump in a size of a corn seed. The lump was gradually enlarged with constant widening of the ulcer. Pain on the tongue was also perceived. The patient was then referred to Hasan Sadikin Hospital for further treatment. Case Management: Patients underwent hemiglossectomy and Selective Neck Dissection (SND) surgical procedures performed by Oral and Maxillofacial Surgeon in collaboration with Surgical Oncologist. Furthermore, after surgery, the patient was consulted to the Hemato-Oncology Division of Internal Medicine Department for chemotherapy treatment. Conclusions: The exact diagnosis was made based on the histopathological biopsy results of the tongue tissue. Management of tongue cancer must be done multidisciplinary. Some things that must be considered in handling such cases are the eradication of the tumor, the return of oral cavity function, and the aesthetic/functional aspects of the patient. Keywords: Oral cancer, Squamous cell carcinoma, Tongue cancer

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Ortholan, C., R. Bensadoun, A. Italiano, S. Teman, O. Dassonville, K. Benezery, A. Lusinchi, J. Thariat, A. Auperin, and J. Bourhis. "Oral cavity squamous cell carcinoma in patients aged 80 or older: Risk factors, treatment, and outcome." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 6064. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6064.

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6064 Background: We have recently reported a large series of patients aged ≥ 80 years showing that in this population about half of head and neck squamous cell carcinomas (SCC) are located in the oral cavity. There are no specific data on this cancer location outcome in elderly patients. Therefore, we report here the experience of two French cancer centers in the treatment of oral cavity SCC in patients aged ≥ 80 years. Methods: Two hundred sixty patients aged ≥ 80 years with a primary oral cavity SCC were included in this retrospective analysis. Results: Sex ratio was near to 1. The risk factor distribution was significantly different between men and women: tobacco/alcohol consumption (66.3% vs 15.8%, p < 0.001), history of leukoplakia/lichen planus/oral traumatism (10.8% vs 55.3%, p = 0.002). Two hundred patients received a loco regional (LR) treatment with a curative intent (surgery and/or radiotherapy), 29 with a palliative intent and 31 did not receive a LR treatment. Curative treatments were delivered according to the institution policy in 56 patients (28%).The median disease specific survival (DSS) was 16.9 months. In multivariate analysis, independent prognostic factors were stage (HR = 0.45 [0.29–0.69], p < 0.001), and curative intent of treatment (HR = 0.28 [0.17–0.45], p < 0.001). Median overall survival (OS) was 13.9 months. In multivariate analysis, the independent prognostic factors for OS were age (HR = 0.63 [0.33–0.76], p < 0.001), stage (HR = 0.61 [0.40–0.91], p = 0,016), and curative intent of treatment (HR = 0.41 [0.23–0.71], p < 0.001. In patients treated with a curative intent, the standard treatment was not associated with improved overall survival or disease specific survival as compared with those treated with an adapted treatment. However, prophylactic lymph node treatment in early stage cancer decreased the rate of nodal recurrence from 38% to 6% (p = 0.01). Conclusions: This study emphasizes the need for prospective evaluation of standard and adapted schedules in elderly patients with oral cavity cancer. No significant financial relationships to disclose.

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Constantinides, Minas S., Stephen G. Rothstein, and Mark S. Persky. "Squamous Cell Carcinoma in Older Patients without Risk Factors." Otolaryngology–Head and Neck Surgery 106, no. 3 (March 1992): 275–77. http://dx.doi.org/10.1177/019459989210600314.

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Ten patients over sixty years of age with no history of tobacco or alcohol use were treated for squamous cell carcinoma of the upper aerodigestive tract between 1979 and 1991. Nine of these ten patients were women with lesions confined to the oral cavity and oropharynx. Modes of treatment included surgery, radiation, or a combination of surgery and radiation. Followup from 1 to 10 years revealed two deaths from local and distant spread, and eight patients with no evidence of disease. Recurrences after treatment were aggressive and occurred within the same region as the primary lesion. Although most patients with upper aerodigestive squamous cell carcinoma are men with alcohol and/or tobacco exposure, this study demonstrates findings consistent with field cancerization in a group of older women with no risk factors.

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Mijatov, Ivana, and Sasa Mijatov. "Application of the eighth edition of the American joint committee on cancer staging system for oral carcinoma." Medical review 72, no. 5-6 (2019): 165–70. http://dx.doi.org/10.2298/mpns1906165m.

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Introduction. Oral squamous cell carcinoma is the sixth most common carcinoma in the world. Annually, it accounts for 5% of all newly discovered cancers. The most important prognostic factor is the stage of the disease. The tumor, node, and metastasis staging system has been the cornerstone for clinical classification of oral squamous cell carcinoma. Material and Methods. The study included 65 patients with oral squamous cell carcinoma who underwent surgery at the Clinic of Maxillofacial Surgery of the Clinical Center of Vojvodina in Novi Sad. The tumor, node, and metastasis status was determined according to 7th and 8th edition of the tumor, node, and metastasis classification. Results. Statistical differences between the 7th and 8th edition of tumor, node, and metastasis classification were examined. There was also a change in the nodal status; in 20% of patients there was a transition from N1 to N2, as a result of a more precise definition of nodal status in patients with oral carcinoma. Conclusion. This research has pointed out the significance of tumor size as a predictive factor in oral squamous cell carcinoma, which indicates the importance of its local control (for surgical and radiological treatment). The 8th edition of the tumor, node, and metastasis classification for oral cavity cancers made a significant shift by clearly defining depth of tumor invasion into the tumor status.

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Mailiza, Fitria, and Rifani Rifani. "Chronic Ulcer Mimicking Oral Squamous Cell Carcinoma (A Case Report)." B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah 6, no. 1 (July 22, 2019): 49–55. http://dx.doi.org/10.33854/jbd.v6i1.211.

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Introduction: Chronic ulcers are considered as the most common ulcerations and can be differentiated with oral squamous cell carcinoma (OSCC) by the presentation of its features. OSCC define as a malignant epithelial neoplasm and the most common neoplasm of the oral cavity. OSCC appears as a mixed white or reddish proliferative growth-like lesion from chronic trauma. Case and management: A 50 years old female came with a painful non-healing ulcer on the lateral right side of the tongue which had been exist since 6 months prior. There had been a gradual increase in the size of the ulcer over the past 6 months. The patient did not have any sistemic disease or bad habits such as chewing or smoking and did not consume alcohol either. Based on the examination, the right submandibular lymphnodes were palpable, tender, firmed and mobile. And there was also a single oval-shaped ulcer with irregular border on the lateral aspect of the tongue in parallel with fractured and decayed lower first molar. The ulcer size was 2x1 cm in diameter, with the base covered by yellowish pseudomembran slough with indurated border. The grinding of the sharp cusp of the tooth was done, followed by the prescription of multivitamins, antibacterial mouthwash and topical corticosteroid. She was also referred to have routine blood test done. She came for the second visit after 14 days, showing improvement of the ulcer. The blood test showed no abnormal values. Discussion: Based on clinical features, the presented lesion was mimicking OSCC. According to the patient’s history taking, clinical examination and appropriate investigation, the patient was diagnosed with traumatic ulcer. Ulcer resolves and heals on the removal of causative factors. Conclusion: Chronic ulcer is one of the most common solitary ulcer presenting in the oral cavity that mimicking OSCC by the presentation of its features. In this reported case, the ulcer arises due to its constant contact with lateral right of the tongue Improvement during the treatment by eliminating suspected risk factors can ruled out the possibility of OSCC thus prevent the unnecessary treatment.

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Schweitzer, Vanessa G., and Melissa L. Somers. "PDT for Tis-T2N0 Oral Cavity and Oropharyngeal Malignancies." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (August 2008): P34. http://dx.doi.org/10.1016/j.otohns.2008.05.112.

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Objective To evaluate the efficacy of PHOTOFRIN-mediated photodynamic therapy (PDT) for treatment of diffuse ‘field cancerization’ and Tis-T2N0M0 squamous cell carcinoma (SqCCa) of the oral cavity and oral pharynx in patients not amenable to or that failed conventional head and neck treatment. Methods This is nonrandomized prospective study of 28 patients with field cancerization and early stage Tis-T2N0M0 squamous cell carcinoma of the oral cavity/oropharynx treated with PHOTOFRIN-mediated PDT. Intravenous PHOTOFRIN (porfimer sodium)(dose 2.0 mg/kg) was administered outpatient, followed 48–60 hours later by intraoperative photoactivation at 630nm via fiberoptic microlens surface delivery (surgical light dose 50–100 J/cm2). Results 21 of 27 patients (77%) have demonstrated complete remission (follow-up 1 month to 12 years). There were 5 patients that had partial remission with recurrence observed at 3, 3, 8, 22, and 23 months subsequently retreated with conventional therapy. All locally disease-free individuals were followed up between 1 to 144 months. 14 of the 21 patients in complete remission were disease-free for a period greater than 1 year following photodynamic therapy. Conclusions PHOTOFRIN-mediated photodynamic therapy can be used as a primary modality to treat Tis-T2N0 tumors of the oral cavity and oropharynx or for treatment for those that have failed prior surgery and/or radiation therapy. PDT allows for preservation of function and structure with absence of systemic toxicity, and patients may have multiple drug administrations and laser light retreatments for local disease control.

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WILDT, JOHN, POUL BJERRUM, and OLE ELBRØND. "Squamous cell carcinoma of the oral cavity: A retrospective analysis of treatment and prognosis." Clinical Otolaryngology 14, no. 2 (April 1989): 107–13. http://dx.doi.org/10.1111/j.1365-2273.1989.tb00345.x.

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Carlesimo, Marta, Alessandra Narcisi, Claudia Abruzzese, Diego Orsini, Giorgia Cortesi, Annalisa Arcese, Armando Bartolazzi, and Germana Camplone. "Efficacy of acitretin in the treatment of squamous cell carcinoma of the oral cavity." European Journal of Cancer Prevention 20, no. 5 (September 2011): 429–30. http://dx.doi.org/10.1097/cej0b013e3283481ddc.

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Ch'ng, Sydney, Justine Oates, Kan Gao, Kerwyn Foo, Sarah Davies, Markus Brunner, and Jonathan R. Clark. "Prospective quality of life assessment between treatment groups for oral cavity squamous cell carcinoma." Head & Neck 36, no. 6 (September 2, 2013): 834–40. http://dx.doi.org/10.1002/hed.23387.

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Gogarty, Darragh S., Paul Lennon, Sandra Deady, J. Barry O’Sullivan, Orla McArdle, Mary Leader, Patrick Sheahan, and James Paul O’Neill. "Variation in treatment and outcome in the early stage oral cavity squamous cell carcinoma." European Archives of Oto-Rhino-Laryngology 274, no. 2 (August 23, 2016): 953–60. http://dx.doi.org/10.1007/s00405-016-4267-z.

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Narayana, Nagamani, Julie Gist, Tyler Smith, Daniel Tylka, Gavin Trogdon, and James K. Wahl. "Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma." Dermatology Research and Practice 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/649731.

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Squamous cell carcinoma (oral SCC) is the most common oral cancer in the U.S., affecting nearly 30,000 Americans each year. Despite recent advances in detection and treatment, there has been little improvement in the five-year survival rate for this devastating disease. Oral cancer may be preceded by premalignant disease that appears histologically as dysplasia. Identification of molecular markers for cellular change would assist in determining the risk of dysplasia progressing to oral squamous cell carcinoma. The goal of this study was to determine if any correlation exists between histological diagnosed dysplasia and OSCC lesions and altered expression of desmosomal cell-cell adhesion molecules in the oral epithelium. Our data showed that oral SCC tissue samples showed decreased immunoreactivity of both desmoplakin and plakophilin-1 proteins compared to normal oral epithelium. Furthermore, significant decrease in desmoplakin immunoreactivity was observed in dysplastic tissue compared to normal oral epithelium. In contrast, the level of desmoglein-1 staining was unchanged between samples however desmoglein-1 was found localized to cell borders in oral SCC samples. These data suggest that changes in expression of desmoplakin and plakophilin-1 may prove to be a useful marker for changes in tissue morphology and provide a tool for identifying pre-neoplastic lesions of the oral cavity.

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Aló, Piero Luigi, Miriam Cicciarelli, Francesca De Felice, Claudia Quintiliani, Alessandro Corsi, and Antonella Polimeni. "Immunohistochemical Differences in Squamous Precancerous and Cancerous Lesions of the Oral Cavity and the Larynx: Preliminary Data." Applied Sciences 11, no. 5 (February 25, 2021): 2048. http://dx.doi.org/10.3390/app11052048.

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The aim of this study is to assess immune cell populations in squamous precancerous (preinvasive) and cancerous lesions of the oral cavity and larynx. Qualitative and quantitative immunohistochemical analyses were performed to determine the expressions of CD4, CD8, CD15, CD57 and CD68. The expressions of programmed death-ligand 1 (PD-L1), p16 and Ki67 were also assessed. Squamous cell lesions from forty-one patients were included in the study. Sixteen samples were categorized as precancerous (preinvasive) lesions and twenty-five as invasive squamous cell carcinoma. Invasive lesions showed a negative correlation with CD57+ cells (ρ = −0.69) and a positive correlation with Ki67 (ρ = 0.61). The amount of CD4+ lymphocytes was higher in invasive lesions. There were no differences in PD-L1 and p16 immunoreactivity. Our analysis showed differences in the immunohistochemical profile between preinvasive and invasive squamous cell lesions. In the near future, this study should be useful in driving treatment strategy in both preinvasive and invasive squamous cell lesions of the oral cavity and larynx. However, studies on larger series of patients focusing on site-specific lesions are required.

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Ketabat, Pundir, Mohabatpour, Lobanova, Koutsopoulos, Hadjiiski, Chen, Papagerakis, and Papagerakis. "Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives." Pharmaceutics 11, no. 7 (June 30, 2019): 302. http://dx.doi.org/10.3390/pharmaceutics11070302.

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Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.

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Sawczuk, Magdalena, Beata Sawczuk, Agnieszka Miąsko, and Izabela Szarmach. "The role of oncogenic viruses in the etiopathogenesis of oral squamous cell carcinoma – literature review." Prosthodontics 68, no. 3 (August 15, 2018): 327–38. http://dx.doi.org/10.5604/01.3001.0012.2563.

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The most common kind of oral cancer is known to be the epithelial cells cancer. The disease develops under the influence of many factors. Extensive studies confirms relationship of the occurrence of cancer in the mouth area and infection with oncogenic virus. Papilloma virus (HPV) and Ebstein-Barr (EBV) are considerate to be the most potent oncogenic viruses. Aim. The aim of the studies was to present the role of the oncogenic virus in the development of squamous cell of oral cancer. Materials and methods. Literature was carried out from November 2014 to January 2018 period using „Pub-Med”, MEDLINE, SCOPUS with keywords: squamous cell carcinoma of the Oral Cavity, oncogenic factors in squamous cell in oral carcinoma, oncogenic virus, role of Ebstein-Barr virus in the development of squamous cell of oral carcinoma, role of human papillomavirus in the development of squamous cell carcinoma. Results. To the review 16 publications were qualified that meet certain criteria for good literature. Identification of comparative characteristics was aimed at finding a common denominator of research results. Discussion. In the review the focus point was on the role of factors which is oncogenic virus. Analysis of the available data has confirmed that more and more frequent cause of commonly known factors such as tobacco smoke, alcohol, neglect hygiene, and genetic factor became undoubtedly the role of virus factor. Summary. High incidence of cancers has led to the search for relevant etiological factors in the development carcinoma process, especially in and around oral cavity. Knowledge of the most cancerogenic factors is important in order to prevent, and the search of effective treatments. In addition, the cited publications, draws attention to the fact the use of saliva as research material. This throws a new light on the work of dentists and the possibility of their involvement in the process of tumor detection and the initiating factor of oncogenesis.

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Pericot, Josep, Josep M. Escribà, Andrés Valdés, Marı́a J. Biosca, Antoni Monner, Xavier Castellsagué, Ramon Galiana, Pere Piulachs, Eloi Escutia, and Antoni Mari. "Survival evaluation of treatment modality in squamous cell carcinoma of the oral cavity and oropharynx." Journal of Cranio-Maxillofacial Surgery 28, no. 1 (February 2000): 49–55. http://dx.doi.org/10.1054/jcms.1999.0091.

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Anderson, Eric, Michael Luu, Diana J. Lu, Anthony Tuan Nguyen, Jon Mallen-St. Clair, Kevin Scher, Alain C. Mita, Allen S. Ho, and Zachary Stephan Zumsteg. "Correlation of pathologic tumor grade with survival in oral cavity squamous cell carcinoma." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e18557-e18557. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e18557.

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e18557 Background: Pathologic tumor grade is a well-established prognostic risk factor that impacts staging and standard-of-care treatment decisions across multiple cancer types. However, the significance of tumor grade in cancers of the head and neck is less certain. Even in oral cavity squamous cell carcinoma (OCSCC), the head and neck cancer subsite with largest body of literature regarding the predictive value of tumor grade is, the prognostic significance of tumor grade remains controversial. Thus, we sought to better elucidate the prognostic importance of tumor grade in OCSCC. Methods: Patients with OCSCC diagnosed from 2004-2015 and undergoing primary surgery with or without adjuvant treatment in the National Cancer Data Base (NCDB) were identified. Overall survival (OS) was estimated using the Kaplan-Meier method with and without propensity score matching (PSM). Univariate and multivariable survival analyses were performed using Cox regression. Analyses were adjusted for multiple clinicopathologic factors, including age, sex, comorbidity status, year of diagnosis, pathologic staging, margin status, number of lymph nodes (LN) examined/positive, extranodal extension (ENE), lymphovascular invasion (LVI), adjuvant radiation, and concomitant chemotherapy. Results: Median follow-up was 40.7 months. Of 13,941 patients with OCSCC, 2,883 had low-grade tumors, 8,716 had intermediate-grade tumors, and 2,342 had high-grade tumors. Higher tumor grade was strongly associated with decreased survival. Specifically, five year OS was 62.7%, 52.8%, and 42.5% in low-grade (LG), intermediate-grade (IG), and high-grade (HG) OCSCC, respectively (p-value < 0.001). In PSM cohorts, OCSCC patients with high-grade had significantly worse 5 year OS (47.7% vs. 57.7%, p < 0.001) in comparison to those with LG OCSCC. Similarly, patients with IG tumors has worse 5-year OS (55.6% vs. 60.3%, p = 0.001) than patients with LG tumors in PSM cohorts. In multivariable analysis, both HG (HR 1.38, 95% CI 1.25-1.52, p < 0.001) and IG (HR 1.17, 95% CI 1.08-1.26, p < 0.001) OCSCC was associated with worse survival than what was observed in LG tumors. The magnitude of the independent effect of tumor grade in multivariable analysis was greater than or equal to what was observed with other well-established prognostic factors like margin positivity (HR 1.34), ENE (HR 1.35), and LVI (HR 1.18). Conclusions: Pathologic tumor grade is a strong predictor of survival among patients with OCSCC. Tumor grade should be considered when making therapeutic recommendations for OCSCC.

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Journal articles on the topic 'Treatment of squamous cell carcinoma of the oral cavity'

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