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Journal articles on the topic 'Treatment Outcomes Foot Ulcers'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

D, Darwin Britto, Rajesh Kesavan, Changam Sheela Sasikumar,, et al. "Autologous platelet-rich fibrin matrix in the treatment of diabetic foot ulcers: a case series." Global Wound Care Journal 1, no. 1 (2025): 36. https://doi.org/10.63896/gwcj.1.1.36.

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Diabetic foot ulcers remain a significant challenge in clinical practice, necessitating innovative strategies to improve healing outcomes. This case series investigates the clinical impact of autologous platelet-rich fibrin matrix (PRFM) in the treatment of non-healing diabetic foot ulcers. By meticulously examining five cases, the study reveals compelling outcomes, including substantial reductions in ulcer size and accelerated healing. Patient-specific considerations, along with a focus on adverse events, provide a comprehensive understanding of the impact of PRFM. The case series underscores

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Rasajnam, Neethu, Sreejith Kalathummarathu, Shehadad Kammili, and Sreedevi Menon. "Clinical Outcome of Chronic Leg and Foot Ulcers Treated with Autologous Platelet Rich Fibrin." Journal of Evolution of Medical and Dental Sciences 11, no. 1 (2022): 33–38. http://dx.doi.org/10.14260/jemds/2022/7.

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BACKGROUND Chronic leg and foot ulcers are a major health problem and leads to negative physical, social and psychological impact on patients and families. A high percentage of chronic ulcers do not adequately heal or quickly relapse with conventional treatment. They need advanced treatment modalities. Emerging cellular therapies such as platelet-rich concentrate therapy is an advanced modality. Platelet rich fibrin (PRF) is a second-generation platelet concentrate, consists of fibrin three-dimensional polymerized matrix, with the incorporation of platelets and leukocytes. The objective of the

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Huizing, Eline, Michiel A. Schreve, James WT Cohen Stuart, Jean-Paul PM de Vries, and Ünlü Çağdaş. "Treatment of clinically uninfected diabetic foot ulcers, with and without antibiotics." Journal of Wound Care 33, no. 2 (2024): 118–26. http://dx.doi.org/10.12968/jowc.2024.33.2.118.

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Objective: Current guidelines do not recommend the use of antibiotics to treat clinically uninfected ulcers. However, physicians continue to prescribe antibiotics for clinically uninfected ulcers with the rationale ‘better to be safe than sorry’. Yet, antibiotic resistance is increasing, side-effects are common and treatment costs are rising. Evidence is needed to identify whether antibiotic treatment for clinically uninfected ulcers can be justified or we should stop prescribing them. The aim of this study was to evaluate whether antibiotic treatment in cases of clinically uninfected ulcers i

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Syeda Safina Naz, L. Manonmani, and Sikandar Basha. "Management of Diabetic Foot Ulcer - A Case Report." Journal of Ayurveda and Integrated Medical Sciences 9, no. 8 (2024): 253–56. http://dx.doi.org/10.21760/jaims.9.8.38.

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Due to sedentary lifestyle of today, diabetes mellitus is becoming a common illness. One of the complications of diabetes mellitus, the primary cause of lower limb amputations, is diabetic foot ulcers. It affects 15% of all diabetes mellitus patients and occurs before lower limb amputation in 84% of people with diabetic foot ulcers. Controlling blood sugar levels, debridement, improved dressings, and offloading techniques are all necessary for the treatment of diabetic foot ulcers. Acharya Sushruta has listed sixty different forms of treatment in the Ayurvedic literature. He has placed particu

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Himshikha, Pandya, Vaibhavkumar Ashokbhai Gambhava, Dhirajlal Ukani Pinal, and Pradyot Nilesh Pandit. "A Study of Diabetic Foot Ulcers in Relation to Duration of Diabetes and Ulcer Severity Scores." International Journal of Toxicological and Pharmacological Research 14, no. 10 (2024): 126–30. https://doi.org/10.5281/zenodo.14537208.

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<strong>Introduction:</strong> The present study explores the relationship between the duration of diabetes and the severity of diabetic foot ulcers using the Diabetic Ulcer Severity Score (DUSS) in a tertiary care setting. By examining ulcer characteristics and healing outcomes, the study aims to identify key factors impacting ulcer severity and treatment outcomes among middle-aged and elderly diabetic patients. <strong>Material and Methods:</strong> This prospective observational study was conducted over one year in the Department of General Surgery at a tertiary care hospital

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Bregovskiy, V. B., A. G. Demina, and I. A. Karpova. "Recurrent foot ulcers in patients with diabetes mellitus in out-patient care." Grekov's Bulletin of Surgery 181, no. 2 (2022): 49–56. http://dx.doi.org/10.24884/0042-4625-2022-181-2-49-56.

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OBJECTIVE. Relapses of diabetic foot ulcers are an urgent problem of outpatient surgery, however, risk factors for relapse, as well as the definition of relapse itself remain a subject of discussion. The presented study investigates the frequency of relapses of ulcerative foot defects in diabetes mellitus, the risk factors for their development and treatment outcomes, based on the definition of relapse as the development of a repeated defect in the same place as the healed defect.METHODS AND MATERIALS. The data of 1714 patients with foot ulcers (2213 ulcerative defects) from 01.2012 to 01.2017

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Shah Hassan, Muhammad Hussain, Sidra, Abdul Basit Khan, Adil ur Rehman, and Awais Khan. "Efficacy of Vacuum Assisted Dressing Technique in the Treatment of Diabetic Foot Ulcers." Indus Journal of Bioscience Research 3, no. 1 (2025): 564–69. https://doi.org/10.70749/ijbr.v3i1.530.

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Background: Diabetic foot ulcers (DFUs) provide significant care issues due to their delayed healing durations and high complication rates. The purpose of this study is to assess the effectiveness of vacuum-assisted dressing in enhancing DFU healing and to identify factors that influence outcomes. Objective: To determine the efficacy of vacuum assisted dressing technique in the treatment of diabetic foot ulcers. Study Design and Setting: A quasi-experimental study was conducted at the Department of Surgery, Mardan Medical Complex Mardan from July 2024 to December 2024. Materials and Methods: T

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Rumanes, Afram, Jaap J. van Netten, Kor H. Hutting, Lisette J. E. W. C. van Gemert-Pijnen, and Jeff G. van Baal. "Offloading Strategies Used for Plantar Diabetic Foot Ulcers and Their Outcomes in Real-Life Clinical Practice." Journal of Clinical Medicine 14, no. 11 (2025): 3834. https://doi.org/10.3390/jcm14113834.

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Introduction: International guidelines describe offloading to facilitate healing as a cornerstone in the treatment of diabetes-related foot ulcers. In present-day clinics, various offloading devices are used. The aim of this paper is to describe the effectiveness in healing of different offloading devices used in real-life clinical practice in patients with diabetes-related foot ulcers. Methods: A retrospective cohort study of 235 patients with a plantar foot ulcer in one diabetic foot centre of expertise was used. Clinical outcomes were determined during a follow-up period of 12 months. Group

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Shah Hassan, Muhammad Hussain, Sidra, Abdul Basit Khan, Adil ur Rehman, and Awais Khan. "Efficacy Of Vacuum Assisied Dressing Technique In The Treatment Of Diabetes In Foot Ulcers." Journal of Bacha Khan Medical College 5, no. 02 (2025): 85–91. https://doi.org/10.69830/jbkmc.v5i02.165.

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Background: Diabetic foot ulcers (DFUs) provide significant care issues due to their delayed healing durations and high complication rates. The purpose of this study is to assess the effectiveness of vacuum-assisted dressing in enhancing DFU healing and to identify factors that influence outcomes. Objective: To determine the efficacy of vacuum assisted dressing technique in the treatment of diabetic foot ulcers. Study Design: A quasi-experimental Study Place and Duration of the Study: Department of Surgery, at Mardan Medical Complex Mardan from March 2024 to August 2024. Materials and Methods:

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Tulsian, Vinay, Rifika Bansal, Sahil Kumar, et al. "Beyond Antibiotics: Exploring Platelet-Rich Plasma Therapy in Diabetic Foot Osteomyelitis—A Case Study." Journal of Cardio-diabetes and Metabolic Disorders 3, no. 1 (2023): 14–17. http://dx.doi.org/10.4103/jcdm.jcdm_1_24.

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Abstract Diabetic foot ulcers affect up to 15% of diabetes patients and can lead to severe complications, including osteomyelitis. Traditional treatment for diabetic foot osteomyelitis typically involves surgery and antibiotics, but outcomes can be suboptimal. This case report explores the use of Platelet-Rich Plasma (PRP) therapy as an adjunctive treatment for a 55-year-old male with Type 2 Diabetes Mellitus and diabetic foot osteomyelitis. The patient was presented with a right foot ulcer and osteomyelitis of the distal fibula, confirmed by MRI and bone scan. After initial treatment with deb

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Saran, Brijesh, Tripta S. Bhagat, and Rohit Bhagat. "Uncommon case of traumatic ulcers in schizophrenia: Treatment and care." Santosh University Journal of Health Sciences 10, no. 2 (2024): 333–36. https://doi.org/10.4103/sujhs.sujhs_61_24.

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ABSTRACT Foot ulcers in individuals with schizophrenia present distinct challenges due to factors like treatment non-compliance and compromised self-care abilities. This case is presented with diagnosis of schizophrenia, hospitalised for non-compliance with medication, the presence of psychotic symptoms, and inadequate self-care and wandering tendency associated with a traumatic foot ulcer reported running barefoot in the streets. A multidisciplinary team, comprising a psychiatrist and a wound care professional, detected the ulcer and commenced antibiotic treatment, leading to recovery. By add

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Prakash, Ved. "Clinical Profile of Patients with Diabetic Foot Ulcer Treated Conservatively or Surgically and Effect of Risk Factors on Ulcer Healing." International Journal of Research and Review 8, no. 6 (2021): 238–44. http://dx.doi.org/10.52403/ijrr.20210629.

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Objective: The aim of this study was to assess the clinical profile of patients with diabetic foot ulcer treated conservatively or surgically and effect of risk factors on ulcer healing. Methods: This was a retrospective observational study conducted in tertiary medical teaching hospital where medical records of diabetic patients who were admitted with foot problem were evaluated. All diabetic patients who were aged >18 years and admitted with DFU were included in this study. A structured proforma was used to collect data from the medical record. SPSS version 20.0 was used to perform the st

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Koreyba, Konstantin, Ekaterina Silina, Dmitry Tsyplakov, et al. "Prognostic Value of Histological and Immunohistochemical Data in Diabetic Foot Ulcers." Journal of Clinical Medicine 11, no. 23 (2022): 7202. http://dx.doi.org/10.3390/jcm11237202.

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Diabetic foot ulcers are an extremely urgent medical and social problem throughout the world. The purpose of this study was to analyse the histological and immunohistochemical features of tissues and cells of different sections of wounds taken during the primary surgical treatment of chronic wounds in patients with diabetic foot syndrome with favourable and unfavourable outcomes. Material and methods. A clinical prospective observational study of the treatment outcomes of fifty-three patients with diabetic foot ulcers hospitalized twice in one specialized centre over the course of the year was

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Tappia, Paramjit S., Brett Hiebert, Rohan Sanjanwala, et al. "A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers." Applied Sciences 11, no. 18 (2021): 8402. http://dx.doi.org/10.3390/app11188402.

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Ineffective healing and treatment of foot ulcers can lead to an infection and gangrene of the wound area that ultimately results in the loss of the limb. The incidence of foot ulcers is higher in patients with diabetes, peripheral vascular disease and kidney disease. Accordingly, this study was undertaken to assess the ability of foot bathing in CO2-enriched water to heal foot ulcers. The design was a double-blinded, randomized, placebo-controlled study. Patients with at least one foot ulcer were randomized to receive either a treatment with bath therapy at 37 ± 0.5 °C containing either 1000–1

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Udovichenko, Oleg Viktorovich, and Eugenia Alexandrovna Berseneva. "Efficacy of routine diabetic foot treatments at an outpatient clinic: a cohort study." Diabetes mellitus 17, no. 3 (2014): 107–12. http://dx.doi.org/10.14341/dm20143107-112.

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Reliable data on the efficacy of treatment for diabetic foot (DF) ulcers (DFUs) is essential for planning outpatient services, comparison of several DF clinics, pharmacoeconomic studies and prognosis of healing time. However, no reports based on Russian DF cases have been published to date.Aim. The aim of our study was to analyse of the outcomes of routine DFU treatments at one DF outpatient clinic (DFOC).Materials and methods. We analysed the medical records of all patients admitted to one DFOC for foot/leg ulcers in 2012 (72 patients, 77 episodes of treatment, 124 ulcers in total). The media

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S, Boopesh, Maharaja P, and Geetha N. "Clinical utility of diabetic ulcer severity score in patients with diabetic foot ulcers – A prospective study." Journal of Medical and Scientific Research 12, no. 02 (2024): 124–28. http://dx.doi.org/10.17727/jmsr.2024/12-23.

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Background: The most common reason for hospitalisation for diabetic people is diabetic foot ulcer (DFU). For diabetic foot ulcers, a variety of scoring systems and classifications are available with the goal of comparing treatment options and long-term results. Aim of the study was to evaluate the effectiveness of the diabetic ulcer severity score, a wound-based clinical scoring system for diabetic foot ulcers, in predicting clinical outcomes. Materials and method: A prospective study was conducted on 65 diabetic ulcer patients. DUSS was applied during the admission. The DUSS consists of four

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Islam, Md Anwarul, Md Rashedul Islam, Farzana Bilqis Ibrahim, Md Morshed Uddin Akand, and Shareen Rahman. "Impact Of Platelet-Rich Plasma Therapy On Claudication Pain And Wound Healing In Diabetic Patients With Peripheral Arterial Disease." IOSR Journal of Dental and Medical Sciences 23, no. 12 (2024): 07–12. https://doi.org/10.9790/0853-2312060712.

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Introduction: Diabetic foot ulcers (DFUs) are a common and challenging complication in patients with diabetes, often leading to pain, delayed wound healing, and in severe cases, limb amputation. This study aimed to assess the impact of platelet-rich plasma therapy on claudication pain and wound healing in diabetic patients with peripheral arterial disease. Methods: This single-center, observational study investigated the effects of autologous platelet-rich plasma (PRP) on pain reduction and wound healing in diabetic patients with peripheral arterial disease (PAD) and foot ulcers. The study too

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Hussain, Fahad, Shivani Kotwal, Nishka Utpat, Sandeepa Utpat, Pranav Phadtare, and Robin Lenz. "Clinical Outcomes of Selective Plantar Fascia Release for Hallux Interphalangeal Joint Ulcers." Wounds: a compendium of clinical research and practice 35, no. 11 (2023): e394-e398. http://dx.doi.org/10.25270/wnds/23093.

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Background. Plantar hallux IPJ ulcers are common and challenging to manage, with many available treatments. One newer technique called SPFR has been used in the management of plantar forefoot ulcers. Objective. This case series reports the clinical results of SPFR for treatment of strictly plantar hallux IPJ ulcers. Materials and Methods. A retrospective chart review was conducted on patients that underwent SPFR procedure by a single foot and ankle surgeon from 2018 to 2023. The primary study outcome was to identify the rate and time of healing associated with SPFR for hallux IPJ ulcers. Only

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Schmidt, Brian M., and Crystal M. Holmes. "Influence of Patient Setting and Dedicated Limb Salvage Efforts on Outcomes in Charcot-Related Foot Ulcer." International Journal of Lower Extremity Wounds 18, no. 4 (2019): 362–66. http://dx.doi.org/10.1177/1534734619861571.

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Charcot neuroarthropathy is a devastating consequence of diabetes mellitus and peripheral neuropathy. Because of its rarity, the condition is often misdiagnosed or poorly managed. When misadventure occurs, patients with Charcot neuroarthropathy can suffer ulceration, infection, amputation, and death. When patients have Charcot-related foot ulcers, the risks are amplified. Utilizing advanced electronic medical record analysis, a 30-month investigation was undertaken to determine if patients with diabetes mellitus and a concomitant diagnosis of Charcot-related foot ulcer were at greater risk of

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Telrandhe, Umesh B., Mohan M. Pethe, and Pankaj M. Middlename Pimpalshende. "Potential Benefits of Moringa oleifera for Diabetic Foot Ulcers - Future Research and Applications." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1918–26. http://dx.doi.org/10.25258/ijpqa.15.3.122.

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Diabetic foot ulcers are permanent scars in people with diabetes that result from nerve damage, inadequate blood flow, and infection. The ulcers not only cause significant financial burdens but also remain poorly controlled, necessitating the need for new therapeutic approaches. Moringa oleifera, or Moringa, has the potential to be more valuable in the treatment of diabetic foot ulcers due to its long-standing and traditional use. Several civilizations, especially in Africa and Asia, have administered the Moringa plant for quite a long period of time, due to its medicinal values in curing woun

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G., Baskaran, Vinodh Kannan T., Subhashini M., Joe Praveen Kumar J., Jyosthna B. V., and Dinesh M. "A study of predictors of lower extermity amputations in diabetic foot ulcer." International Surgery Journal 11, no. 8 (2024): 1277–81. http://dx.doi.org/10.18203/2349-2902.isj20242118.

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Background: Diabetic foot ulcers (DFUs) are severe complications in diabetes, leading to significant morbidity and mortality. A simplified classification system including precise prediction indicators for lower extremity amputations (LEA) would aid decision-making. Methods: This prospective observational study included 100 patients with diabetic foot ulcers admitted to Government Villupuram Medical College & Hospital over one year. Results: Approximately 38% of the patients were above 60 years, 31% were aged 51-60 years, and 12% were under 40 years. The mean age was 56.67 with a standard d

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Ravidas, Vishnu S., Samadarsi P., and Ajayan G. "Prospective observational study evaluating association of sociodemographic parameters, Wagner’s grading, peripheral arterial disease and diabetic peripheral neuropathy with the outcomes of diabetic foot ulcers." International Surgery Journal 7, no. 7 (2020): 2129. http://dx.doi.org/10.18203/2349-2902.isj20202528.

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Background: The present study was conducted to determine the association of sociodemographic parameters, comorbid conditions and complications of diabetes mellitus (DM) with the treatment outcomes of diabetic foot ulcers.Methods: The present prospective observational study enrolled 105 participants aged 30-85 years with diabetic foot ulcers presenting to general surgery department during a period of 18 months. Participants who were terminally ill, who had trophic ulcers of Hansen’s disease and filariasis and its sequelae were excluded. The study was approved by institutional ethics committee a

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Jha, Sarvagya Chirag, and Hemang Ashokbhai Panchal. "Local wound insulin infiltration (injection) and topical timolol gel versus normal saline and povidone iodine in treatment of diabetic foot ulcer." International Surgery Journal 12, no. 6 (2025): 961–67. https://doi.org/10.18203/2349-2902.isj20251536.

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Background: Diabetic foot ulcers (DFUs) are a common complication of diabetes mellitus, contributing significantly to patient morbidity. Effective wound management remains a challenge, prompting investigations into novel treatment methods. This randomized controlled study compares the efficacy of local wound insulin infiltration with topical timolol gel versus standard treatment with normal saline and povidone iodine for DFUs. To evaluate and compare the ulcer healing outcomes of local insulin with topical timolol gel versus normal saline with povidone iodine in treating diabetic foot ulcers.

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Havilah D,, Havilah D,, Medhani Sri K. Medhani Sri K, SD N. Shariff SD N Shariff, and Panchumarthy Ravishankar. "Walking On Thin Ice: Understanding and Preventing Diabetic Foot Ulcers." Journal of Medical and Dental Science Research 11, no. 11 (2024): 25–34. https://doi.org/10.35629/076x-11112534.

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Diabetic foot ulcers (DFU) are a serious side effect of diabetes that frequently results in amputations, extended hospital stays, and infections. Peripheral artery disease (PAD), neuropathy, smoking, long-term diabetes, foot abnormalities, and a history of ulcers or amputations all raise the chance of developing DFUs. Usually, a combination of Gram-positive and Gram-negative bacteria, anaerobes, and fungi cause the infections in DFUs. Comprehensive care, such as blood glucose management, lifestyle modifications, routine foot assessments, appropriate footwear, and patient education, is the focu

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Sezikli, İsmail. "Key points in the success of diabetic foot ulcer treatment." Injector 2, no. 3 (2024): 88–89. https://doi.org/10.5281/zenodo.13821185.

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Dear Editor, Diabetic foot ulcers (DFUs) represent a significant challenge in diabetic patient care due to their chronic nature and potential for severe complications, including infection and amputation. Recent advances in understanding the pathophysiology and management of DFUs have highlighted several critical areas that can enhance treatment success. Timely identification of patients at risk for DFUs is paramount. Tools such as the Diabetic Foot Risk Classification System enable clinicians to stratify patients based on ulcer risk, facilitating early interventions (1). Regular foot examinati

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Manoj, Prabhu M., H. Sudeshna, J. Harini, S. Elavarasan, and B. Ganeshan. "AI driven detection and remediation of Diabetic Foot Ulcer (DFU)." i-manager’s Journal on Pattern Recognition 11, no. 2 (2024): 1. https://doi.org/10.26634/jpr.11.2.21088.

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Diabetic foot ulcers (DFUs) constitute a significant health concern in India, affecting a substantial portion of diabetic patients. Without prompt intervention, these ulcers can result in severe complications, including infection, gangrene, amputation, and chronic wounds. Approximately 72% of DFU patients test positive for multidrug-resistant organisms (MDROs), further elevating the risk of complications. Early detection is critical to preventing such outcomes. This prototype leverages artificial intelligence (AI) and deep learning techniques, specifically Convolutional Neural Networks (CNNs),

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Filho, Markinokoff Lima e. Silva, André Oliveira Paggiaro, Viviane Fernandes de Carvalho, and Rolf Gemperli. "Ozone therapy as a treatment for diabetic foot ulcers: a systematic review and meta-analysis." Journal of Wound Care 33, no. 12 (2024): 958–67. https://doi.org/10.12968/jowc.2022.0189.

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Objective: Studies have suggested that ozone therapy stimulates antioxidant enzyme expression and activity, regulates growth factor production, increases local blood flow and provides antibacterial protection. We sought to analyse the evidence related to the use of ozone therapy in the treatment of diabetic foot ulcers (DFUs). Method: A systematic review and meta-analysis was conducted using published clinical trials indexed in the PubMed, Embase and Web of Science databases up to December 2020. Outcomes analysed included: number of ulcers cured; ulcer area reduction; length of hospital stay;

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Saraswat, Bharti, Kapil Kumar Gill, Ashok Yadav, and Krishan Kumar. "A prospective observation study on diabetic foot ulcer using diabetic ulcer severity score at tertiary care hospital." International Surgery Journal 8, no. 12 (2021): 3553. http://dx.doi.org/10.18203/2349-2902.isj20214744.

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Background: A number of scoring systems and classifications are available for diabetic foot ulcers with intention to compare the treatment modalities and future outcomes. Many of them are complex and don’t predict future outcome within the patients. Aim and objectives of current study were to establish a wound-based clinical scoring systems (DUSS) as daily clinical practice by assessing the efficacy of diabetic ulcer severity score.Methods: A total of 73 diabetic patients with foot ulcers were included in this prospective observational study conducted at Dr. S.N. Medical college, Jodhpur and a

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Dumont, Isabelle J., Marc Lepeut, Coralie Segalen, Yannis Guillemin, and Jean Noel Gouze. "Use of GBT013, a Collagen-Based Dressing, for the Healing of Diabetic Foot Ulcers." Journal of the American Podiatric Medical Association 108, no. 5 (2018): 419–29. http://dx.doi.org/10.7547/16-102.

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The number of people with diabetes is expected to reach 592 million in the year 2035. Diabetic foot lesions are responsible for more hospitalizations than any other complication of diabetes. The aims of this study were to examine for the first time a new biocompatible and biodegradable tridimensional collagen-based matrix, GBT013, in humans for diabetic foot ulcer wound healing and to evaluate its ease of use to better define a protocol for a future clinical trial. Seven adult patients with a diabetic foot ulcer of grade 1A to 3D (University of Texas Diabetic Wound Classification) were treated

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D., Ashokkumar, Vinothkumar S., and Heber Anandan. "Outcome of patients undergoing amputation for diabetic foot ulcer." International Surgery Journal 6, no. 1 (2018): 88. http://dx.doi.org/10.18203/2349-2902.isj20185125.

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Background: Foot ulcers are the principal cause of severe complications and hospitalization among patients with diabetes, substantially increasing the costs with this disease. Peripheral neuropathy, ulceration, infection, and peripheral vascular disease are the principal factors for ulcer complications and loss of a lower limb in diabetic patients. The aim of the present endeavor was to study the patients undergoing amputation for the diabetic foot ulcer.Methods: Total 150 patients with diabetic foot ulcer were included in this study. The variables investigated were related to diabetes, infect

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Kalinin, R. E., I. A. Suchkov, N. D. Mzhavanadze, et al. "Regenerative technologies in treatment of diabetic foot ulcers." Genes & Cells 12, no. 1 (2017): 15–26. http://dx.doi.org/10.23868/gc120634.

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Regenerative medicine is one of the new fast growing approaches to the treatment of a variety of diseases, including oncology and cardiovascular pathology, degenerative-dystrophic diseases of bones and joints, and other complex diseases including diabetes mellitus. Diabetes is regarded as one of the most dangerous non-infectious diseases in the world with a rising incidence that reaches pandemic proportions. Treatment of patients with diabetic foot ulcers including those with peripheral arterial disease is a challenging issue due to the increased risks for poor and lethal outcomes, which makes

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Yammine, Kaissar, Marc Nahed, and Chahine Assi. "Metatarsal Osteotomies for Treating Neuropathic Diabetic Foot Ulcers: A Meta-analysis." Foot & Ankle Specialist 12, no. 6 (2018): 555–62. http://dx.doi.org/10.1177/1938640018819784.

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Diabetic foot ulcers (DFUs) are usually treated with conservative management based on debridement, topical agents, and nonsurgical off-loading; however, the recurrence rate following such standard care is reported to be high. In the case of recalcitrant or recurrent ulcers, a surgical off-loading technique such as the metatarsal osteotomy (MO) is indicated. Thus, the aim of this study is to conduct a meta-analysis evaluating the efficacy of MO in treating DFUs. Four relevant studies were identified, including 119 patients with 129 DFUs; all wounds were refractory to a previous conservative tre

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A, Ramesh, G. Rajendran, Uma D, and Prasanna Venkatesh. "Outcome of normal saline versus collagen dressing in management of diabetic foot ulcer – A comparative study." Panacea Journal of Medical Sciences 13, no. 1 (2023): 160–64. http://dx.doi.org/10.18231/j.pjms.2023.033.

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: Diabetic Foot ulcer is a major disease-causing disability to many patients around the world. Treatment of diabetic foot ulcers (DFU), which is the most common reason for lower-extremity amputation, remains a serious healthcare problem. : To compare the normal saline dressing with collagen dressing in diabetic foot ulcer treatment. : This comparative study was conducted on 100 patients, randomised into 50 patients in each group, Normal saline dressing and Collage dressing. The ulcer was evaluated after every 3 days to reduce the size, formation of granulation tissue and epithelisation until t

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Komariah, Maria, Juan Alessandro Jeremis Maruli Nura Lele, Audrey Gunawan, et al. "The Model and Efficacy of Online Nurse-led on the Clinical Outcome of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials." F1000Research 13 (April 23, 2024): 375. http://dx.doi.org/10.12688/f1000research.135373.1.

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Background: The most frequent consequence for those with diabetes mellitus is diabetic foot ulcers. Diabetic ulcer treatment must be done properly and on time. The development of online-based intervention by nurses, such as messaging health, may improve the clinical outcome of diabetic foot ulcers by providing easier access, more convenience, and cost-effectiveness, especially for patients in rural areas. Objective: This study aimed to perform a systematic review and meta-analysis the models and efficacy of online nurse-led intervention on clinical outcomes of diabetic foot ulcers. Methods: Ra

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Alhubail, Asma, May Sewify, Grace Messenger, et al. "Microbiological profile of diabetic foot ulcers in Kuwait." PLOS ONE 15, no. 12 (2020): e0244306. http://dx.doi.org/10.1371/journal.pone.0244306.

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Introduction Diabetic foot ulcers (DFU) and infection (DFI) are a major diabetes-related problem around the world due to the high prevalence of diabetes in the population. The aim of our study was to determine the microbiological profile of infected ulcers in patients attending Dasman Diabetes Institute (DDI) clinics in Kuwait and to analyze the distribution of microbial isolates according to wound grade, sex, age and diabetes control. Methods We collected and analyzed clinical data and samples from 513 diabetic patients with foot ulcers referred to our podiatry clinic at DDI from Jan 2011 til

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Ramirez-Acuña, Jesus Manuel, Sergio A. Cardenas-Cadena, Pedro A. Marquez-Salas, et al. "Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments." Antibiotics 8, no. 4 (2019): 193. http://dx.doi.org/10.3390/antibiotics8040193.

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Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to serious physical consequences like amputations of limbs and equally severe social, psychological, and economic outcomes. It is reported that up to 25% of patients with diabetes develop a DFU in their lifetime, and more than half of them become infected. Therefore, it is essential to manage infection and ulcer recovery to prevent negatives outcomes. The available information plays a significant role in keeping both physicians and patients aware of the emerging therapies against DFUs. The purpose of this rev

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Ramani, Pratha Anantha, Murali Manohar Deevi, Simhadri Uday Kiran, et al. "Clinico-microbiological profile and outcome of diabetic foot ulcers." International Surgery Journal 7, no. 8 (2020): 2626. http://dx.doi.org/10.18203/2349-2902.isj20203245.

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Background: Diabetic foot ulcers (DFU) are debilitating to the patients and significantly impair their quality of life. DFU associated with infection have the worst outcomes and may lead to amputations if timely intervention is not done. In the present study, aim was to identify the association between the type of organism isolated and the rates of amputations in diabetic foot ulcers.Methods: We retrospectively studied 50 diabetic foot ulcers from January 2017 to June 2017, who were in-patients in a single unit of surgery department in King George Hospital, Visakhapatnam. Baseline clinical exa

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Primous, Nathaniel R., Peter T. Elvin, Kathleen V. Carter, et al. "Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review." Journal of Clinical Medicine 13, no. 5 (2024): 1221. http://dx.doi.org/10.3390/jcm13051221.

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Diabetic foot ulcers (DFUs) pose a significant threat to individuals with diabetes mellitus (DM), such as lower limb amputation and severe morbidity. Bioengineered skin substitutes (BSS) are alternatives to traditional interventions for treating DFUs, but their efficacy compared to standard wound care (SWC) or other treatment types, such as allografts, remains unknown. A scoping review of human studies was conducted to identify current approaches in the treatment of DFUs using BSS as compared with other treatment options. Systematic searches in PubMed, Cochrane Library, and Web of Science were

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Brem, H., P. Shehan, and A. J. M. Boulton. "Current protocol and outcomes in the treatment of diabetic foot ulcers." Journal of Tissue Viability 15, no. 1 (2005): 24. http://dx.doi.org/10.1016/s0965-206x(05)51021-0.

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Gomez, Paul T., Karen L. Andrews, Jennifer R. Arthurs, Alison J. Bruce, and Saranya P. Wyles. "Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcers." Advances in Skin & Wound Care 37, no. 11&12 (2024): 608–15. http://dx.doi.org/10.1097/asw.0000000000000229.

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ABSTRACT BACKGROUND Chronic nonhealing neuropathic foot ulcers affect approximately 15% to 30% of patients with diabetes mellitus and are associated with significant morbidity and mortality. Although current strategies to address these chronic wounds include a multifactorial approach, clinical outcomes remain poor and warrant improvement. Platelet-rich plasma (PRP), derived from autologous or allogeneic blood, is an emerging regenerative product that aims to serve as an adjuvant to standard diabetic foot ulcer (DFU) treatment. OBJECTIVE To examine controlled clinical trials investigating the e

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Alex Arthur Edwards and M J Shaahar. "Utilizing the SINBAD score to assess amputation risk in diabetic foot ulcers." World Journal of Biology Pharmacy and Health Sciences 22, no. 3 (2025): 566–71. https://doi.org/10.30574/wjbphs.2025.22.3.0644.

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Background: Diabetic foot ulcers (DFUs) represent a serious complication of diabetes, often resulting in significant morbidity and limb loss. This study aimed to assess the predictive value of the SINBAD scoring system—which includes Site, Ischemia, Neuropathy, Bacterial infection, Area, and Depth—in identifying the risk of major foot events, particularly amputations, in patients with DFUs. Material and Methods: A prospective observational study was carried out at Sree Mookambika Institute of Medical Sciences from November 2023 to November 2024. A total of 150 patients diagnosed with diabetic

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Alkhatieb, Maram T., Mahmood T. Alkhatieb, Raseel K. Abideen, Hussain A. Alkhalifah, Haifa M. Alnahdi, and Khalid M. Edrees. "Common pathogens associated with infected diabetic foot ulcers: A retrospective cohort study in a specialized medical center in Jeddah, Saudi Arabia." Journal of Family Medicine and Primary Care 13, no. 7 (2024): 2724–29. http://dx.doi.org/10.4103/jfmpc.jfmpc_12_24.

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ABSTRACT Background: Foot infections, a frequent complication of diabetes mellitus, are associated with heavy resource utilization, including antibiotic therapy and surgeries. However, the most common type of isolated pathogen in diabetic foot infections remains unknown. We aimed to identify the most common types of isolated pathogens in diabetic foot infections. Methods: This retrospective cohort study was conducted in a specialized medical center in Jeddah, Saudi Arabia. A total of 96 patients diagnosed with diabetes and presented with a foot ulcer showing clinical signs of infection were in

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Diniz Freitas, Claudia, Eduardo Araújo Pires, Carlos Eduardo Roncatto, and Roberto Attílio Lima Santin. "PO 18251 - Functional clinical outcome of the conservative treatment of calcaneal fractures in patients with diabetic neuropathy." Scientific Journal of the Foot & Ankle 13, Supl 1 (2019): 57S. http://dx.doi.org/10.30795/scijfootankle.2019.v13.1052.

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Introduction: Calcaneal fractures are potentially serious in diabetic patients with foot insensitivity. The consensus is that surgical treatment involves a high risk of complications in these cases, and conservative treatment is the option of choice because it allows monitoring of the onset of pressure ulcers and the degree of hindfoot collapse, which usually occurs as Charcot arthropathy progresses. Objective: To retrospectively evaluate the mid-term functional clinical outcome of conservative treatment of calcaneal fractures in diabetic patients with advanced peripheral neuropathy associated

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Muhammad Qasim, Arbab Haroon, Mehboob Ullah, et al. "Prevalence and Antibiotic Susceptibility Pattern of Pseudomonas Aeruginosa from the Foot Ulcer of Diabetic Patients in Hayatabad Medical Complex Peshawar, Pakistan." Journal of Health and Rehabilitation Research 4, no. 2 (2024): 414–20. http://dx.doi.org/10.61919/jhrr.v4i2.877.

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Background: Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, affecting 15% of diabetic patients and often leading to severe outcomes like amputation. These ulcers frequently become infected with bacteria such as Pseudomonas aeruginosa, which is known for its robust antibiotic resistance. Objective: To investigate the prevalence and antibiotic susceptibility patterns of Pseudomonas aeruginosa isolated from the foot ulcers of diabetic patients in Hayatabad Medical Complex, Peshawar. Methods: A total of 103 clinical samples from diabetic foot ulcers were collected and an

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Demir, Levent, Murat Kahraman, İbrahim Altun, Mustafa Avcı, Selahattin Kılıç, and Sena Aslan. "Clinical outcomes of topical epidermal growth factor in diabetic foot ulcers." Journal of Medicine and Palliative Care 6, no. 1 (2025): 39–44. https://doi.org/10.47582/jompac.1600752.

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Aims: This study aims to evaluate the clinical outcomes of topical epidermal growth factor (EGF) in the treatment of diabetic foot ulcers (DFUs) in outpatient settings. It also seeks to provide guidance on the use of topical EGF, which is eligible for reimbursement for treating DFUs in our country. Methods: A retrospective analysis involved 55 patients with DFUs who received topical EGF treatment. Patients received training on EGF application and were monitored for healing outcomes. Data were collected from medical records, including demographic information, wound characteristics, and laborato

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Rerkasem, Kittipan, Natapong Kosachunhanun, Siam Tongprasert, et al. "Reducing Lower Extremity Amputations Due to Diabetes: The Application of Diabetic-Foot Protocol in Chiang Mai University Hospital." International Journal of Lower Extremity Wounds 7, no. 2 (2008): 88–92. http://dx.doi.org/10.1177/1534734608317939.

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The aim of this study was to determine whether intensive treatment and education strategies for diabetic patients with ulcers help in preventing leg amputation. From August 2005 to March 2007, a diabetic-foot protocol using a multidisciplinary approach was applied at our hospital. All the subjects were educated regarding diabetic-foot disease and its complications and prevention. This report compares the amputation rate in patients receiving the protocol care from August 2005 to March 2007 with those who had standard care from August 2003 to July 2005. Seventy-three and 110 diabetic-foot ulcer

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Kumar, Anjani, Bijay Nanda Naik, Vishnu Shankar Ojha, et al. "Factors associated with severity and outcomes of diabetic foot ulcers: A single center hospital-based cross-sectional observational study in Eastern India." Journal of Family Medicine and Primary Care 14, no. 4 (2025): 1431–36. https://doi.org/10.4103/jfmpc.jfmpc_1703_24.

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ABSTRACT Background: Diabetes mellitus (DM) affects millions globally and is associated with high morbidity, risk of infection, and potential for severe outcomes. In India, where the prevalence of diabetic foot complications is notably high, data on factors influencing the severity and outcomes of diabetic foot ulcers (DFUs) in specific regions, particularly Eastern India, remain sparse. Methods: This hospital-based cross-sectional study included Type 2 DM patients aged over 18 years, excluding those unwilling to participate and those with ulcers classified as Wagner grade less than 2. The stu

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Austin, Publishing Group. "Revascularization in Diabetic Foot Ulcer and Outcome." Austin Journal of Surgery 8, no. 5 (2021): 1280. https://doi.org/10.26420/austinjsurg.2021.1280.

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Introduction Diabetes is a major public health problem regionally and globally. In 2019, the International Diabetes Federation estimated that 465 million (9.3%) people worldwide had diabetes, and by 2045, the number may rise to 700 million (10.9%) [1]. The pooled prevalence of diabetes in the general population of Bangladesh is 7.8% and prevalence of pre-diabetes is 10.1% [2]. Diabetes is a complex disease with many serious potential sequelae, including large vessel arterial disease and microvascular dysfunction. The lifetime risk for foot ulcers in people with diabetes is estimated to be 15%

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Arvind Kumar Shukla, Avinash Gautam, Jujar Kapadia, et al. "A study to assess the efficacy of local applicants to prevent complications of diabetic foot." Asian Journal of Medical Sciences 14, no. 8 (2023): 80–84. https://doi.org/10.71152/ajms.v14i8.3671.

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Background: Diabetes is one of the most common comorbid illnesses in our community. Diabetes is associated with numerous complications related to microvascular, macrovascular, and metabolic etiologies. One of its complications in long course is diabetic foot ulcer and the associated morbidity and mortality is a major health issue. Aims and Objectives: This study was conducted to describe the lesions we treat, study and compare outcomes and to identify measures to decrease morbidity and mortality due to diabetic foot disease. Materials and Methods: All patients who attended general surgery outp

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Arvind Kumar Shukla, Avinash Gautam, Jujar Kapadia, et al. "A study to assess the efficacy of local applicants to prevent complications of diabetic foot." Asian Journal of Medical Sciences 14, no. 8 (2023): 80–84. http://dx.doi.org/10.3126/ajms.v14i8.53148.

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Background: Diabetes is one of the most common comorbid illnesses in our community. Diabetes is associated with numerous complications related to microvascular, macrovascular, and metabolic etiologies. One of its complications in long course is diabetic foot ulcer and the associated morbidity and mortality is a major health issue. Aims and Objectives: This study was conducted to describe the lesions we treat, study and compare outcomes and to identify measures to decrease morbidity and mortality due to diabetic foot disease. Materials and Methods: All patients who attended general surgery outp

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