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Dissertations / Theses on the topic 'Treatment responder'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gloster, Andrew T., Rainer Sonntag, Jürgen Hoyer, et al. "Treating Treatment-Resistant Patients with Panic Disorder and Agoraphobia Using Psychotherapy: A Randomized Controlled Switching Trial." Karger, 2015. https://tud.qucosa.de/id/qucosa%3A71640.

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Background: Nonresponsiveness to therapy is generally acknowledged, but only a few studies have tested switching to psychotherapy. This study is one of the first to examine the malleability of treatment-resistant patients using acceptance and commitment therapy (ACT). Methods: This was a randomized controlled trial that included 43 patients diagnosed with primary panic disorder and/or agoraphobia (PD/A) with prior unsuccessful state-of-the-art treatment (mean number of previous sessions = 42.2). Patients were treated with an ACT manual administered by novice therapists and followed up for 6 mo

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2

Byström, Per. "Colorectal cancer treatment and early response evaluation how do we best evaluate treatment response? /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-766-5/.

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3

Clowes, Jackie A. "The effect of dietary factors and osteoporosis treatment on bone turnover." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251195.

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4

Singh, Namrata. "The Effects of Parent Training in Pivotal Response Treatment (PRT) and Continued Support through Telemedicine on Gains in Communication in Children with Autism Spectrum Disorder." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/315907.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Introduction: With the increase in children diagnosed with autism spectrum disorders (ASD) each year comes the need for individualized interventions necessary for children with autism. Many of the treatments currently available are time consuming, costly, and rely heavily on behavioral interventionists despite the lack of qualified interventionists to provide these services. Therefore, there is a growing recognition of the need for ef

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5

Philip, Judith Mary Dundas. "Immune responses following Praziquantel treatment of schistosomiasis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615292.

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6

Matthiasson, Páll. "Dealing with treatment resistance to clozapine : characteristics of treatment response in schizophrenia." Thesis, King's College London (University of London), 2006. https://kclpure.kcl.ac.uk/portal/en/theses/dealing-with-treatment-resistance-to-clozapine--characteristics-of-treatment-response-in-schizophrenia(f43c968b-8789-44e7-9161-3cab811ee429).html.

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Background: Clozapine, the treatment of choice in treatment-resistant schizophrenia, is not effective in up to half of patients. Aims of this thesis were: to verify whether clozapine augmentation with amisulpride, an atypical antipsychotic with preferential affinity at doparninergic D2-like receptors, is clinically effective; to test the prediction that changes in D2-like receptor availability might explain that improvement; to explore clinical and receptor availability characteristics of good clozapine responders. Methods: Study 1: Thirty-three patients with schizophrenia, partially or non-re

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7

Sunkara, Sesh. "Interventions for poor responders undergoing in vitro fertilisation treatment." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/interventions-for-poor-responders-undergoing-in-vitro-fertilisation-treatment(63a0ad08-f73f-406e-93db-7aa226d4c160).html.

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This thesis examines the various interventions proposed for the management of poor responders undergoing IVF treatment. I began by performing a systematic review and meta-analysis to identify the ideal controlled ovarian hyperstimulation (COH) regimen for women with poor ovarian response undergoing IVF. The systematic review found the evidence to be inconsistent and inconclusive. The poor responders intervention trial (PRINT) was thus conceived. PRINT is an RCT comparing the gonadotrophin releasing hormone (GnRH) agonist long versus the GnRH agonist short versus the GnRH antagonist regimens fo

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8

Weverling, Gerrit Jan. "Measuring treatment response in HIV-1 infection." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/83204.

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9

Quinn, Stephen. "Uterine fibroids : response to novel treatment modalities." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24737.

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Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive, thermal ablation treatment for uterine fibroids. There is currently limited data regarding the long-term efficacy of this method and the effect of this treatment on circulating cytokine and growth factors. In this thesis I have: 1. Presented the most accurate method of measuring fibroid volumes, and propose a new classification system for describing fibroid uteri. 2. Reviewed the characteristics of a cohort of uterine fibroid subjects and perform a longitudinal analysis of MRgFUS results. 3. Assessed the fibroid volume tr

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10

Ghadiri, Mahtab. "Peripheral Immune Phenotyping in Multiple Sclerosis: Immunomodulatory Treatment Effects and Treatment Response Biomarkers." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20809.

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Disease modifying therapies (DMTs) used in the treatment of relapsing remitting multiple sclerosis (RRMS) have broad effects on the immune system that are incompletely understood. There is great heterogeneity in treatment response to most DMTs. However, biomarkers predicting treatment response are lacking. In this thesis, the peripheral immune changes induced by treatment with two DMTs, fingolimod (FTY) and dimethyl fumarate (DMF), are examined in detail by immune phenotyping using multicolour flow cytometry. Chapter 3 presents a longitudinal study of T cell subsets in patients commencing tr

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11

Corcoran, R. J. "Fruit fly (Diptera:Tephritidae) responses to quarantine heat treatment /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16489.pdf.

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12

Lawton, Frank. "An assessment of the clinical role of urinary polyamine measurement in epithelial ovarian cancer." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256403.

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13

Goozee, Rhianna Mae. "The neurobiological basis of treatment response in psychosis." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/the-neurobiological-basis-of-treatment-response-in-psychosis(227079ee-19b1-46e5-b8a7-121118d665a3).html.

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Antipsychotic treatment response is unpredictable and variable, and there are currently no reliable neurobiological assessment methods to predict treatment efficacy. Previous research suggests that psychosis is associated with several brain abnormalities and that some of these may be associated with poorer treatment response. This thesis investigated the association between brain function (salience attribution during fMRI and perfusion) and treatment response at 4 and 12 weeks in antipsychotic-naïve patients with their first episode of psychosis. Twenty-five first episode psychosis patients to

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14

Warden, Sarah Jean. "Sex differences in response to treatment with risperidone." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq24708.pdf.

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15

Ng, Hung-yu Ernest, and 吳鴻裕. "Excessive ovarian response during in-vitro fertilisation treatment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29636218.

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16

Mirza, Ahmad. "Markers of treatment response for gastro-oesophageal cancers." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/markers-of-treatment-response-for-gastrooesophageal-cancers(c53c4845-7120-4490-831d-c27bfc823a93).html.

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Introduction: The incidence of gastro-oesophageal cancers has increased considerably over the last decade. As the disease is associated with a poor prognosis, there is a need to identify markers of treatment response which could be used in the future to improve the management of gastro-oesophageal tumours. Aims: 1) To compare the ability of published histological grading criteria (Becker, Mandard and Ninomiya) to assess response to neo-adjuvant chemotherapy (NCT) in gastro-oesophageal cancers. 2) To evaluate the expression of thymidylate synthase (TS) in pre-treatment diagnostic biopsy samples

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17

Latif, Ay§e. "Genetics of breast cancer susceptibility and treatment response." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525641.

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18

Loftås, Per. "Response to neoadjuvant treatment in rectal cancer surgery." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132759.

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Rectal cancer is one of the three most common malignancies in Sweden with an annual incidence of about 2000 cases. Current treatment consists of surgical resection of the rectum including the loco-regional lymph nodes in the mesorectum. In advanced cases, neoadjuvant chemo-radiotherapy (CRT) prior to the operative treatment reduces local recurrences and enables surgery. The neoadjuvant treatment can also eradicate the tumour completely, i.e. complete response. This research project was designed to investigate the effects of preoperative radiotherapy/ CRT and analyze methods to predict response

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19

Legge, Sophie E. "Examining treatment response and adverse effects of clozapine." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91366/.

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The antipsychotic clozapine is uniquely effective in the management of treatmentresistant schizophrenia (TRS), but its use is limited by its potential to induce agranulocytosis. A substantial proportion of patients discontinue clozapine treatment, which carries a poor prognosis, and only 30-60% of patients with TRS will respond to clozapine. The causes of clozapine-associated agranulocytosis, and of its precursor neutropenia, are largely unknown although genetic factors contribute. To examine the genetic susceptibility to clozapine-associated neutropenia, I conducted a multifaceted genetic ana

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20

Patricia, van Es Nina. "Illness and the Treatment Response: The Patient's View." PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/4886.

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In American society, where the biomedical profession is institutionalized and its therapies dominate health care, a decision to deviate from prevailing norms can be considered remarkable. Yet research done by Eisenberg et al. (1993) found that unconventional or alternative medicine had an "enormous presence" in U.S. health care and that one in three persons had utilized an unconventional therapy in 1990. The objective of this thesis was to explore this phenomenon. Individuals who had used alternative and biomedical intervention to treat a disorder were recruited through practitioners of altern

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21

Bodini, M. "Genomics of treatment response in Acute Myeloid Leukemia." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/469570.

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Acute Myeloid Leukaemia (AML) is a cancer of the myeloid lineage of blood cells characterised by rapid growth of undifferentiated myeloid precursors that accumulate in the bone marrow and suppress normal haematopoiesis. It is the most common adult leukaemia with an estimated number of more than 60’000 new cases for the US in 2016. Despite the high rates of complete remissions achieved after treatment (60-80% in young adults), the number of patient that will result cured after induction and consolidation therapy is very low (~12%). The molecular basis of relapsing disease is still unclear and t

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22

Ho, Kam-yuen Simon, and 何錦源. "Healing responses following surgical/non-surgical treatment in residual periodontally-involved sites." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B43895463.

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23

Scott, Wayne C. University of Ballarat. "Male domestic partner abusers : typologies and responses to treatment." University of Ballarat, 2006. http://archimedes.ballarat.edu.au:8080/vital/access/HandleResolver/1959.17/12785.

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"Although awareness of the pervasiveness and significance of partner abuse has been growing, little data exist on matching type of abusers with specific interventions. The aim of this study was to evaluate one example of the empirically based typologies of partner abuse that could lead to improved interventions for abusers."<br>Doctor of Psychology (Clinical)

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24

Scott, Wayne C. "Male domestic partner abusers : typologies and responses to treatment." University of Ballarat, 2006. http://archimedes.ballarat.edu.au:8080/vital/access/HandleResolver/1959.17/15392.

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"Although awareness of the pervasiveness and significance of partner abuse has been growing, little data exist on matching type of abusers with specific interventions. The aim of this study was to evaluate one example of the empirically based typologies of partner abuse that could lead to improved interventions for abusers."<br>Doctor of Psychology (Clinical)

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25

Hung, Suk-mei Damaris. "Coping resource and treatment responses in back pain patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B29688735.

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26

Hassan, Syeda Saleha. "Modulation of human immune responses during anti-tuberculosis treatment." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557276.

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27

Scott, Wayne. "Male domestic partner abusers : Typologies and responses to treatment." Thesis, University of Ballarat, 2006. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/69516.

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"Although awareness of the pervasiveness and significance of partner abuse has been growing, little data exist on matching type of abusers with specific interventions. The aim of this study was to evaluate one example of the empirically based typologies of partner abuse that could lead to improved interventions for abusers."<br>Doctor of Psychology (Clinical)

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28

Peters, Curtis Lee 1958. "SURFACE RESPONSE OF ONIONS TO CULTURAL TREATMENTS." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276358.

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29

Kondo, Yumi. "Identification of worsening subjects and treatment responders in comparative longitudinal studies." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57447.

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This thesis discusses the problems of identifying worsening individuals in on-going clinical trials and treatment responders in completed trials. We develop a new modelling approach to enhance a recently proposed method to detect increases of contrast enhancing lesions (CELs) on repeated magnetic resonance imaging, which have been used as an indicator for potential adverse events. The method signals patients with unusual increases in CEL activity by estimating the probability of observing CEL counts as large as those observed on a patient's recent scans conditional on the patient's CEL counts

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30

Keeley, Kathryn Marie. "A Social response perspective on treatment allocation in psychiatry." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27497.

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Huge mental hospitals are being replaced by smaller psychiatric units in medium and even small community hospitals. This biomedical setting results in pressure to adopt a more biological focus for treatment. It is, therefore, imperative that hospital psychiatry develop an alternative model which retains the social context of mental illness. Social response theory is used to analyze the research findings and to emphasize the need for a social perspective in the development of hospital psychiatry, for institutional health care planning, and for society as a whole. In this study, a cohort of 10

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31

Hendlisz, Alain. "Multimodality imaging for treatment response prediction in colorectal cancer." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209109.

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L’hypothèse prédominante de cette thèse est que les changements métaboliques tumoraux mesurés par FDG-PET/CT sous l’influence des traitements anticancéreux, apparaissent plus précocement et parfois exclusivement par rapport aux modalités d’imagerie morphologique classique. L’imagerie multimodale, en combinant les avantages de chacune des techniques, dépasse leur limitations et pourrait permettre (i) une évaluation du bénéfice du traitement plus rapide et plus adéquate ;(ii) de modifier les algorithmes thérapeutiques à différents stades de cancer colorectal et (iii) d’améliorer la compréhension

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32

Day, S. E. "Detection of tumour treatment response using hyperpolarized 13C pyruvate." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598434.

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The exchange reaction between hyperpolarized 1-<sup>13</sup>C pyruvate and lactate, catalysed by the enzyme lactate dehydrogenase (LDH), can now be measured in real-time with <sup>13</sup>C nuclear magnetic resonance spectroscopy and imaged in tissues using <sup>13</sup>C MRI. EL-4 murine lymphoma cells catalyse this pyruvate-lactate exchange in a substrate-dependent fashion, and we demonstrate that the reaction is inhibited following treatment with chemotherapeutic drugs both <i>in vitro</i> and <i>in vivo</i>. The LDH reaction specifically labels the intratumoural lactate pool present within

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33

Ramsay, Jonathan R. "Experimental studies on prediction of response to cancer treatment." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388333.

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34

Gafson, Arie R. "Predicting response to disease modifying treatment in multiple sclerosis." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/56612.

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Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS) that most commonly begins with a relapsing-remitting course (RRMS). Many disease modifying treatments now are available, but none have efficacy in all patients, all are expensive and all are associated with possible adverse events. Stratifying patients to the best tolerated and most efficacious treatment either prior to or soon after commencing treatment would enhance relative benefits and reduce harm. Effective stratification depends on an understanding of relevant aspects of a drug’s mechanism of acti

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35

Lapiner, Vanessa. "Melanocyte survival and response to treatment in Vitiligo Patients." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3070.

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Vitiligo is a common depigmenting skin disorder with devastating psychological implications. Although evidence strongly suggests that melanocytes die in various forms of vitiligo, it is also evident, at least in certain cases, that melanocytes/melanoblasts survive in an undifferentiated stem cell form and it is from these that re-pigmentation is assumed to occur. Treatment of this distressing condition remains 'hit-or-miss' and patients' responses are unpredictable. This study aims to integrate prognostic variables such as the molecular profile of vitiliginous lesions and the patient's epidemi

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36

Shazadi, Kanvel. "Genetic predictors for epilepsy development, treatment response and dosing." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/14119/.

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Antiepileptic drug (AED) treatment is the first line strategy for seizure control in the majority of individuals with epilepsy but remains challenging, not least because of interindividual variability in efficacy, tolerability and dosing. The studies presented in this thesis set out to explore that variability from a genomic perspective in patients with newly diagnosed epilepsy from across the UK. Single nucleotide polymorphisms (SNPs) in genes encoding drug metabolising enzymes (DMEs) may be associated with the dose of carbamazepine (CBZ) required for seizure control. A cohort of 159 individu

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37

Kraft, Jeffrey Brian Jr. "Antidepressant pharmacogenetics: Searching for genetic determinants of treatment response." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311330.

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38

Renner, Bobbi Jean 1953. "Factor affecting the treatment response of drug-addicted women." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290656.

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This study was a 4-year longitudinal evaluation of a therapeutic community for drug addicted women. Pre-treatment variables of interest included 3 major indices of resources that served as predictors of women's response to treatment. Psychological measures and a willingness for treatment comprised the personal resources index. Early family environment factors and current family relationship measures comprised the family resources index. The third index, social resources, included social support networks and social adaptation measures, including pre-treatment length of drug use, criminal involv

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39

Boettcher, Carl Michael. "Development of a surface engineering treatment for the Timet 550 Î± + Î² titanium alloy." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288938.

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40

Sehlstedt-Persson, Margot. "Properties of solid wood : responses to drying and heat treatment." Licentiate thesis, Luleå : Luleå tekniska universitet, 2005. http://epubl.ltu.se/1402-1757/2005/70/.

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41

Rubinson, Emily. "MODULATION OF VACCINE-INDUCED RESPONSES BY ANTHELMINTIC TREATMENT IN PONIES." UKnowledge, 2014. http://uknowledge.uky.edu/medsci_etds/4.

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Vaccines and anthelmintics induce an inflammatory response in equids. Since they are commonly given concurrently, it is practical to study any interaction between them. This study evaluated whether IVM and PYR would modulate the acute phase inflammatory response, the systemic gene expression of pro-inflammatory cytokines, and vaccine-specific titers induced by WNV, EHV, and KLH vaccines. Naturally-infected, yearling ponies were sorted by gender, then fecal epgs. They were randomly assigned to three treatment groups: IVM, PYR, and control. All ponies received vaccinations intramuscularly on day

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42

Joyce, Ieuan Michael. "Ovarian responses of ewes to growth hormone and gonadotrophin treatment." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243681.

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43

Liu, Wenyu. "Group-sequential response-adaptive designs for comparing several treatments." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24657.

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Previous work on two-treatment comparisons has shown that the use of optimal response-adaptive randomisation with group sequential analysis can allocate more patients to the better-performing treatment while preserving the overall type I error rate. The sequence of test statistics for this adaptive design asymptotically satisfi es the canonical joint distribution. The overall type I error rate can be controlled by utilising the error-spending approach. However, previous work focused on immediate responses. The application of the adaptive design to censored survival responses is investigated an

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Nødtvedt, Ane Christine Wammer. "Parasites in lactating dairy cattle, epidemiology and response to treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63261.pdf.

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Johansson, Dennis. "Strength and colour response of solid wood to heat treatment." Licentiate thesis, Luleå : Luleå University of Technology, 2005. http://epubl.ltu.se/1402-1757/2005/93/LTU-LIC-0593-SE.pdf.

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46

Brunstein, Flavia. "Histamine's vasoactive properties improving response rates in solid tumor treatment." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2006. http://hdl.handle.net/1765/10500.

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Pothecary, Mark Richard. "Characterisation of the endothelial response to treatment with oligomeric procyanidins." Thesis, Queen Mary, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444998.

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Sillah, Abdul Karim. "Markers of treatment response for gastric and gastro-oesophageal cancers." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506252.

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The hypothesis underlying the thesis was that the management of gastro-oesophageal cancer patients could be enhanced by improving the histological and radiological diagnosis of the disease and increasing understanding of its underlying biology.

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Hasan, Khaled Muhsen. "Capillary rarefaction : importance in cardiovascular risk and response to treatment." Thesis, St George's, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268890.

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Strawbridge, Rebecca Clare. "Biomarkers of inflammation as predictors of treatment response in depression." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-inflammation-as-predictors-of-treatment-response-in-depression(0b70b627-0c8b-462b-9868-7c99ceb000ff).html.

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People suffering with depression often do not respond sufficiently to current treatments. A wealth of research suggests that mood disorders are associated with higher levels of inflammation, yet this literature currently provides an inadequate description of the nature of the depressive disorders studied and involves extensive heterogeneity between patients and study methodologies. This thesis comprises three studies examining a broad spectrum of circulating pro-inflammatory proteins before and after interventions for depression, to test specific hypotheses that raised inflammatory markers pre

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