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Journal articles on the topic 'Treaty of Amity'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Desierto, Diane A. "Alleged Violations of the 1955 Treaty of Amity, Economic Relations, and Consular Rights (Iran v. U.S.) (Judgment on Preliminary Objections) (I.C.J.)." International Legal Materials 61, no. 1 (2021): 1–40. http://dx.doi.org/10.1017/ilm.2021.45.

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On February 3, 2021, the International Court of Justice delivered its judgment on preliminary objections in Alleged Violations of the 1955 Treaty of Amity, Economic Relations, and Consular Rights (Islamic Republic of Iran v. United States of America). The judgment rejected all of the United States’ preliminary objections, declared the admissibility of Iran's Application, and held that the Court has jurisdiction “on the basis of Article XXI, paragraph 2 of the Treaty of Amity, Economic Relations, and Consular Rights of 1955.”

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Krupenya, Iryna. "ECONOMIC DIPLOMACY OF UKRAINE IN THE SOUTHEAST ASIA SUBREGION." Politology bulletin, no. 92 (2024): 413–28. http://dx.doi.org/10.17721/2415-881x.2024.92.413-428.

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It was established that according to the ASEAN Charter there are 3 types of cooperation: Dialogue Partnerships, Sectoral Dialogue Partnerships, Development Partnerships, and there are separate observer and guest statuses. The possibility of non-Southeast Asian countries the Treaty of Amity and Cooperation in Southeast Asia was studied, and Ukraine’s experience of joining the Treaty since 2017 was analyzed. It was emphasized that although the Treaty of Amity and Cooperation in Southeast Asia was a symbol of good-neighborly relations between ASEAN countries, it was also considered as a contractu

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En-Mei (王恩美), Wang. "“The Issue of Overseas Chinese in Korea” in the Signing of the “Treaty of Amity between the Republic of China and the Republic of Korea” (1952–1964) (「中韓友好條約」簽訂過程中的「韓國華僑問題」(1952–1964))". Translocal Chinese: East Asian Perspectives 10, № 1 (2016): 33–59. http://dx.doi.org/10.1163/24522015-01001003.

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After 1949, the Republic of China and the Republic of Korea sought mutual cooperation and amity on the basis of anti-communism. The two nations used terms such as “brotherly nations” and “strong alliance” to refer to the relation between them. Despite the continuous publicizing both within the nations and internationally, the anti-communist alliance ofrocandrokdid not run as smoothly as it seemed. In fact, the two nations have never entered into a treaty of military alliance. “Treaty of Amity between the Republic of China and the Republic of Korea”, a treaty representing their amity, was not e

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Nuchkoom Smith, Nucharee, and Robert Brian Smith. "Has Thailand learnt any Lessons from the Bowring Treaty and the Treaty of Amity?" ATHENS JOURNAL OF LAW 5, no. 4 (2019): 405–18. http://dx.doi.org/10.30958/ajl.5-4-3.

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Anderson, Scott. "Introductory Remarks by Scott Anderson." Proceedings of the ASIL Annual Meeting 113 (2019): 141–58. http://dx.doi.org/10.1017/amp.2019.198.

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Over the past two years, we have really seen the Trump administration make treaty withdrawal something of a signature move, from the Treaty of Amity with Iran to the Intermediate-Range Nuclear Forces Treaty, to the Optional Protocol for the Vienna Convention on Diplomatic Relations. The administration has taken steps to remove the United States, rightly or wrongly, from a wide array of longstanding international legal obligations. And while it is far from unprecedented, the administration has done so at a little bit of a faster pace than certain prior administrations have—and has embedded a lo

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Williams, Mark Stephen, and Selina Haynes. "Canada’s Accession to ASEAN’s Treaty of Amity: Cooperation and Diplomatic Presence in Southeast Asia." Canadian Political Science Review 17, no. 1 (2023): 77–97. http://dx.doi.org/10.24124/c677/20231865.

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Abstract This article examines Canada’s accession to the Treaty of Amity and Cooperation (TAC) with the Association of Southeast Asian Nations (ASEAN). As one of only a select group of 10 countries from outside of Southeast Asia that is a Dialogue Partner with ASEAN, Canada has gained important diplomatic and market presence in the Indo-Pacific. Furthermore, Canada’s national interests are advanced through the accession to TAC by supporting a rules-based system of regional order. The foundations of ASEAN—based on sovereignty, consensus, and the process of informality—make the “ASEAN Way” frust

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Park, Han-Min. "Conclusion process of The Joseon-Japan treaty of Amity in Byeongja yorok(丙子擾錄)". Korea-Japan Historical Review 63 (28 лютого 2019): 45–85. http://dx.doi.org/10.18496/kjhr.2019.02.63.45.

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Kim, Jong Hak. "Kang wi’s Visit to Beijing and the Conclusion of the Joseon-Japanese Treaty of Amity in 1876." Review of Korean and Asian Political Thoughts 21, no. 1 (2022): 1–37. http://dx.doi.org/10.35161/rkapt.2022.03.21.1.1.

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9

Chachko, Elena. "Alleged Violations of the 1955 Treaty of Amity, Economic Relations, and Consular Rights (Islamic Republic of Iran v. United States of America): Request for the Indication of Provisional Measures (I.C.J.)." International Legal Materials 58, no. 1 (2019): 71–119. http://dx.doi.org/10.1017/ilm.2019.2.

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On October 3, 2018, the International Court of Justice (ICJ) issued a unanimous order indicating limited provisional measures against the United States. Iran initiated the case, Alleged Violations of the 1955 Treaty of Amity, Economic Relations, and Consular Rights (Iran v. United States), after the United States announced its decision to withdraw from the Joint Comprehensive Plan of Action (JCPOA) and revoke related sanctions relief for Iran. While the ICJ found that it had prima facie jurisdiction to hear the case—contrary to the U.S. position—the provisional measures it granted fell signifi

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Pimenova, Sofia. "The case of Certain Iranian Assets (Iran v. USA): missed opportunity for the ICJ and procedural tricks of the parties." Meždunarodnoe pravosudie 13, no. 3 (2023): 3–17. https://doi.org/10.21128/2226-2059-2023-3-3-17.

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This article analyzes the circumstances of the case of Certain Iranian Assets (Islamic Republic of Iran v. United States of America) that has been decided by the International Court of Justice in 2023. The author examines the arguments of the parties and the conclusions reached by the Court in the judgment on jurisdiction in 2019 and in the judgment on the merits of the dispute in 2023. It is noted that the main issue in this case was the legality, in terms of customary international law, of the actions of the U.S. authorities to seize the assets of Bank Markazi to pay compensation awarded by

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Amaya-Castro, Juan M. "List of Current Proceedings: Update." Leiden Journal of International Law 12, no. 4 (1999): 847–50. http://dx.doi.org/10.1017/s0922156599000436.

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Indonesia and Malaysia jointly seized the Court on 2 November 1998 of their dispute concerning sovereignty over Pulau Ligitan and Pulau Sipadan, two islands in the Celebes Sea. They did so by notifying the Court of a Special Agreement, which was signed between them on 31 May 1997 at Kuala Lumpur and entered into force on 14 May 1998. In the Special Agreement, the Parties request the Court “to determine on the basis of the treaties, agreements and any other evidence furnished by [them], whether sovereignty over Pulau Ligitan and Pulau Sipadan belongs to the Republic of Indonesia or to Malaysia.

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Robertson, Marta. "Floating Worlds: Japanese and American Transcultural Encounters in Dance." Congress on Research in Dance Conference Proceedings 2014 (2014): 126–35. http://dx.doi.org/10.1017/cor.2014.18.

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The repurposed metaphor “floating worlds,” from Japanese woodblock prints, highlights political junctions when transcultural American and Japanese dance collide and reconfigure. The first “floating world” is an “Ethiopian Concert” presented by Commodore Matthew Perry's Japanese Olio Minstrels in celebration of The Treaty of Peace and Amity (1854). The second challenges nostalgic Western notions of an “Old Japan” through the aggressively westernized Tokyo School of Music, where modern dancer Michio Ito trained for an opera career. Third, a post–World War I Peace Festival in Washington, DC, whic

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Seah, D. "The Treaty of Amity and Cooperation in Southeast Asia: The Issue of Non-Intervention and its Accession by Australia and the USA." Chinese Journal of International Law 11, no. 4 (2012): 785–822. http://dx.doi.org/10.1093/chinesejil/jms057.

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Badruzaman, Idham. "ASEAN Way in Korean Peninsula Peacebuilding." Indonesian Journal of Peace and Security Studies (IJPSS) 2, no. 1 (2020): 16–30. http://dx.doi.org/10.29303/ijpss.v2i1.34.

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As stated by Johan Galtung, one fundamental principle in establishing peace is to involve the conflicting parties into a constructive dialogue. By this principle, ASEAN avoids isolative approach by welcoming Pyongyang in ASEAN Regional Forum (ARF) in 2000 and cultivating a trustworthy relationship afterwards. Driven by ASEAN Fundamental Principle in The Treaty of Amity and Cooperation (TAC) 1976, ARF appeared to be effective to maintain North Korea in negotiating table, as it also remains to be the only multilateral framework North Korea is in. This ASEAN soft diplomacy in peacebuilding also g

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Deineko, D. O. "Legal framework and political conditions of peaceful cooperation of the ASEAN. Accession of Ukraine to the Treaty of Amity and Cooperation in Southeast Asia." Legal position, no. 2 (2022): 27–35. http://dx.doi.org/10.32836/2521-6473.2022-2.5.

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16

Stewart, David P. "Phillips Petroleum Co. Iran v. Islamic Republic of Iran." American Journal of International Law 85, no. 1 (1991): 184–91. http://dx.doi.org/10.2307/2203573.

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Phillips Petroleum Co. Iran, a wholly owned subsidiary of Phillips Petroleum Co., brought a claim before the Iran-United States Claims Tribunal against the Islamic Republic of Iran and the National Iranian Oil Co. (NIOC) seeking compensation for the alleged taking of its rights under a joint agreement for the exploration and exploitation of petroleum resources in the Persian Gulf. Chamber Two of the Tribunal concluded that the claimant had been deprived of its property interests during the Iranian Revolution by conduct attributable to the Government of Iran for which respondents were liable to

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Gunawan, Yordan, Verocha Jayustin Sastra, Adyatma Tsany Prakosa, Mutia Ovitasari, and Lathifah Yuli Kurniasih. "THE VALIDITY OF TURKEY-LIBYA’S AGREEMENT ON MARITIME BOUNDARIES IN INTERNATIONAL LAW." Jurnal Hukum dan Peradilan 9, no. 2 (2020): 170. http://dx.doi.org/10.25216/jhp.9.2.2020.170-185.

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The conflicts between Turkey and Greece have been going on for a long time. Several conflicts caused tension between Turkey and Greece, such as the territory of Aegean, Cyprus, and other problems. The tension increased because the bilateral agreement between Turkey and Libya on the maritime boundaries of the Eastern Mediterranean, which signed in 2019, was opposed by Greece because the Agreement did not take into account the existence of the island which owned by Greece. The Agreement between Turkey and Libya made Greece furious because Greece considered that the action violated Greece’s sover

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Gürsel, Bahar. "“Probably the best meal that I have as yet indulged in” : An American missionary’s description of Korean dishes in 1909." International Journal of Korean History 27, no. 2 (2022): 165–95. http://dx.doi.org/10.22372/ijkh.2022.27.2.165.

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In the wake of the Chosǒn-United States Treaty of Peace, Amity, Commerce and Navigation (1882), the relationship between the Korean Empire and the Western world intensified, and large groups of diplomats, missionaries and travelers arrived in the peninsula. Lloyd H. Snyder was among those newcomers and acted as a missionary educator intermittently for more than thirty years in Korea. This article employs a letter－which was sent by Snyder in 1909 to a visitor from the United States－as a primary source to elucidate how an inexperienced American missionary explicated the details of a meal that he

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Putri, Alvela, Putri Jasmine, Riana Salma, Galang Bagasta, and M. Padhil Faturrahman. "Dampak Prinsip-Prinsip Dasar ASEAN Terhadap Pola Kerjasama ASEAN Menghadapi Krisis Kudeta Myanmar." Nation State: Journal of International Studies 4, no. 1 (2021): 117–39. http://dx.doi.org/10.24076/nsjis.v4i1.488.

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ASEAN as a regional organization has fundamental principles that underlie all activities carried out by member countries. This basic principle was recorded in the TAC (Treaty of Amity and Cooperation in South-East Asia) in 1976. However, in February 2021, one of the ASEAN member countries, Myanmar, was facing a crisis caused by a coup by the Myanmar military. ASEAN has a fundamental principle that keeps member countries from interfering with each other. However, the Myanmar crisis could affect other member countries and ASEAN cooperation. This study aims to determine the pattern of ASEAN coope

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Ambarwati, Ambarwati. "SIKAP ASEAN TERHADAP PELANGGARAN HAM DI MYANMAR PASCA KUDETA." Jurnal Ilmiah Dinamika Sosial 6, no. 1 (2022): 20–36. http://dx.doi.org/10.38043/jids.v6i1.3360.

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Tulisan ini menganalisis mengenai sikap ASEAN dalam menghadapi pelanggaran HAM di Myanmar pasca kudeta militer Februari 2021. Dalam beberapa kasus, ASEAN sering diposisikan dalam kondisi dilema dalam mengambil sikap terhadap pelangaran HAM, dilema antara memegang teguh prinsip non-interfere dan melindungi hak asasi manusia (responbility to protect/R2P). Dalam kasus pelanggaran HAM di Myanmar, ASEAN juga dianggap berada di dilema. ASEAN telah memiliki prinsip non-intervensi yang tertuang dalam TAC (Treaty and Amity Cooperation) yang selama ini dipegang sebagai code of conduct dalam interaksi an

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Morris, P. Sean. "Intellectual Property Investment at the International Court of Justice After Certain Iranian Assets." Global Trade and Customs Journal 18, Issue 11/12 (2023): 476–81. http://dx.doi.org/10.54648/gtcj2023058.

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In Certain Iranian Assets, the International Court of Justice (ICJ) acknowledges that the protection of patents is part of the broader remit of a corporate entity with legal personality in international law. The case was not about intellectual property investments, nor was it a case about investment protection in the proper sense of that body of law. However, when the Court, in very light form, mentions the protection of patents, the World Court raises the bar for the dynamics of intellectual property investments in international law. This comment seeks to do two things. Frist, it will map out

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Iqbal, Ramadhan. "Building Cybersecurity Regulation in Southeast Asia: A Challenge for the Association of Southeast Asian Nations (ASEAN)." Journal of Social and Political Sciences 3, no. 4 (2020): 983–95. https://doi.org/10.31014/aior.1991.03.04.230.

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For each nation-state, technology has become a new backbone. It links a range of critical infrastructures, including finance, banking, security, water, electricity, and transport. As Southeast Asia's dominant regional body, ASEAN enjoys privileges and benefits from emerging technology. In recent years, digital trade has enhanced the economic growth of ASEAN. Nßon-traditional threats such as a cyber attack are, however, the result of the modern world. Malware, malware, and advanced persistent threat (APT) lurk in every corner of cyberspace, seeking to cripple and shut down ASEAN's

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Seah, Daniel. "The CFSP as an aspect of conducting foreign relations by the United Kingdom: With special reference to the Treaty of Amity & Cooperation in Southeast Asia." International Review of Law 2015, no. 1 (2015): 1. http://dx.doi.org/10.5339/irl.2015.1.

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Kwak, Hyunyong. "Analysis of ROK-US Alliance Treaties Applying Autonomy-Security Trade-off Model -Focusing on Treaty of Amity and Commerce between the United States of America and Corea and Mutual Defense Treaty between the Republic of Korea and the United States of America-." Review of Korean Military Studies 7, no. 2 (2018): 39–64. http://dx.doi.org/10.34166/rokms.2018.7.2.39.

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Budi Pramono. "The Indonesia's Strategies For Exclusive Economic Zone (EEZ) Sovereignty With 1982 UNCLOS Provisions: North Natuna Sea." DEFENDONESIA 7, no. 1 (2023): 41–63. http://dx.doi.org/10.54755/defendonesia.v7i1.128.

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North Natuna Sea's abundance of natural resources provides a tremendous pull for diverse parties, who, for the sake of profit maximization, are willing to commit any crime. A further report found that the claims of South East Asean countries and China on Indonesia's Exclusive Economic Zone (EEZ) waters in North Natuna Sea are completely divorced from the attractiveness of the natural resources. Considering the strategies to resolve any differences and the disputes between South East Asean countries and China in a peaceful manner through dialogue, affirming commitment to the goals and principle

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Krupenya, I. "THE POLICY OF THE ASEAN COUNTRIES TOWARD UKRAINE FOLLOWING RUSSIA’S FULL-SCALE INVASION." National Technical University of Ukraine Journal. Political science. Sociology. Law, no. 4(56) (December 21, 2022): 43–49. http://dx.doi.org/10.20535/2308-5053.2022.4(56).269606.

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The study is devoted to the analysis of the positions of the ASEAN countries toward Ukraine following Russia’s full-scale invasion and the historical prerequisites for the formation of the official position of the ASEAN countries regarding the war in Ukraine. The historically neutral foreign policy course of the ASEAN countries is explained in view of the Kuala Lumpur Declaration of 1971 on the creation of a zone of peace, freedom and neutrality in the Southeast Asia subregion. The article provides the results of the monitoring of the interactive world map of the Ministry of Foreign Affairs of

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Syam, M. Husni, and Eka An Aqimuddin. "ASEAN and the Frankenstein dilemma: Will ASEAN become a monster?" F1000Research 11 (May 9, 2022): 502. http://dx.doi.org/10.12688/f1000research.110377.1.

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Background: International organizations are pivotal as actors in international relations. Although its establishment represents a state, they have their objectives separate from their creators. The Association of Southeast Asian Nations [ASEAN] was created to handle cooperation and maintain peace and security in Southeast Asia. Although ASEAN was equipped with institutional organs to fulfil its purposes, member states' influence is unavoidable. This situation raises the Frankenstein dilemma in which creators cannot fully control its creature. This research aims to elaborate on ASEAN as a separ

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PARK, Han-min. "Japan’s East Sea Coast Reconnaissance Activities and the Opening of the port in Wonsan." Association for Korean Modern and Contemporary History 107 (December 31, 2023): 7–42. http://dx.doi.org/10.29004/jkmch.2023.12.107.7.

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Located in Hamgyeong Province on the East Sea coast, Wonsan was the second port to be opened next Busan after Joseon signed ‘The Joseon-Japan treaty of Amity’ in 1876. This area was where the warship Unyo(雲揚艦) conducted reconnaissance activities and contacted local people while moving up along the East Coast at the time of its first visit in June 1875. The voyage log of the warship Unyo clearly reveals the investigation of the environment around Broughton Bay(永興灣), the contempt that they had for the local people, and the contact with the local people. Miyamoto Okazu(宮本小一) also concluded that W

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Jain, Amit Kumar C. "Amit Jain’s Offloading Ladder in Diabetic Foot." SAR Journal of Surgery 5, no. 02 (2024): 14–16. http://dx.doi.org/10.36346/sarjs.2024.v05i02.002.

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Diabetic foot ulcers are common in clinical practice and they are often difficult to treat, especially the plantar ulcers which are common in patients with neuropathy. One modality of treatment that is important is offloading of the foot. There are distinct offloading methods used in clinical practice in different parts of the world. In this article, author suggest a practical offloading ladder approach for diabetic foot ulcers.

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WEXLER, HARRY K., GERALD MELNICK, LOIS LOWE, and JEAN PETERS. "Three-Year Reincarceration Outcomes for Amity In-Prison Therapeutic Community and Aftercare in California." Prison Journal 79, no. 3 (1999): 321–36. http://dx.doi.org/10.1177/0032885599079003003.

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The study assessed 36-month recidivism outcomes for a prison therapeutic community (TC) program with aftercare using an intent-to-treat design with random assignment. Outcomes for 478 felons at 36 months replicated findings of an earlier report on 12- and 24-month outcomes, showing the best outcomes for those who completed both in-prison and aftercare TC programs. At 36 months, 27% of the prison TC plus aftercare completers recidivated, versus 75% for other groups. In addition, a significant positive relationship was found between the amount of time spent in treatment and the time until return

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Abosch, Yishaiya. "An Exceptional Power." Political Research Quarterly 66, no. 1 (2012): 18–31. http://dx.doi.org/10.1177/1065912911434160.

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In a late dialogue on English common law, Hobbes addressed a perennial problem: how to allow exceptions to general rules without amplifying divisive claims of sovereign arbitrariness. His solution extended Leviathan’s arguments against lawyers but also relied heavily on a conception of equity that the earlier treatise tended to obscure. For Hobbes, equity was not only a mode of sovereign adjudication, but also an instrument for molding dispositions conducive to “Civill Amity.” Long-term stability therefore demanded that the sovereign power to make exceptions be limited by a general human capac

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Abbey, Ruth. "Review Essay: On Friendship." Review of Politics 79, no. 4 (2017): 695–707. http://dx.doi.org/10.1017/s0034670517000444.

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The topic of friendship is enjoying a renewed interest among political theorists and philosophers. The three books reviewed here join several other recent works on friendship and the creation of a journal of friendship studies,Amity. Despite their shared focus on friendship, the three works under review complement rather than duplicate one another. Alexander Nehamas's work is designed for a general readership, with scholarly nuance being largely relegated to the notes. The books by P. E. Digeser and Ann Ward are more typical academic publications. While Ward focuses almost exclusively on Arist

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Altaf, Husain, Tiwari Ujjwal, Sharma Vijay, Kumar Amit, and Rais Nadeem. "Effect of Nyctanthes Arbortristis Linn. Leaves Against Streptozotocin Induced Oxidative Stress in Rats." International Journal Of Pharma Professional's Research 1, no. 1 (2010): 10–13. https://doi.org/10.5281/zenodo.7702654.

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<strong>Abstract:</strong> Nyctanthes arbortristis Linn. (Fam: Nyctanthaceae) is commonly known as ‘Harsinghar’ and its leaves are traditionally used to treat fevers, rheumatism, liver disorders and as expectorant. The present work is aimed to evaluate the effect of leaves of N. arbortristis on antioxidant enzymes status in streptozotocin induced diabetic rats. STZ diabetic rats showed decreased levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) in serum as compared to normal. Diabetic animals were treated with 50% ethanolic extra

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Neupane, Rabin, Saloni Malla, Mariam Sami Abou-Dahech, et al. "Abstract 5656: Design and development of novel anticancer dimethoxyquinazoline-4-amine analog, DW-8, against colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): 5656. http://dx.doi.org/10.1158/1538-7445.am2022-5656.

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Abstract Patients with advanced or metastatic colorectal cancer (CRC) often have poor prognosis and survival. There are ongoing efforts to identify novel molecules to manage advanced and metastatic CRC. Modifications in the quinazoline ring has resulted in effective and clinically approved drugs such as gefitinib, erlotinib, vandetanib among others. We rationalized and synthesized a series of 4-anilinoquinazoline analogues, DW (1-10) and evaluated them for anticancer efficacy in human CRC cell lines (HCT116, HT29, SW620). We identified a lead molecule DW-8, with sub-micromolar potency against

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Spinrad, A., D. Taliaz, and R. Zoller. "Predicting the effect of antidepressant treatment on relief from anxiety symptoms." European Psychiatry 65, S1 (2022): S187. http://dx.doi.org/10.1192/j.eurpsy.2022.492.

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Introduction Depression and anxiety disorders are among the most prevalent forms of mental illness, with antidepressants frequently used to treat them. Unfortunately, prescription of antidepressant medication is often inexact and relies on a long trial-and-error process. Objectives Using machine Learning (ML) algorithms on readily obtainable clinical and demographic data of individuals diagnosed with depression with anxiety symptoms, we hypothesized that we will be able to derive models which will enable a more accurate treatment selection, focusing on relief from anxiety symptoms. Methods Pat

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Karagounis, Ilias V., Jayashree Karar, Christoforos Thomas, et al. "Abstract 217: A novel class of dimeric quinacrine compounds induce DNA damage and increase the anticancer activity of radiation." Cancer Research 82, no. 12_Supplement (2022): 217. http://dx.doi.org/10.1158/1538-7445.am2022-217.

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Abstract Radiation therapy is commonly used to treat cancers in the definitive setting, but the local control often remains suboptimal, thereby motivating us to search for novel radiosensitizers. Recently a series of novel quinacrines based upon a previously reported dimeric chloroquine has been synthesized. We studied one of these agents, DQ660. By itself, the drug upregulates both p53 protein and p53 transcriptional targets and also increases apoptosis in p53-wildtype H460 lung cancer cells. Furthermore, we found that DQ660 is a potent radiosensitizer in vitro. This radiosensitization is not

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Rasoulouniriana, Diana, Nadine Santana-Magal, Amit Gutwillig та ін. "Abstract 4075: A modified FcγRI expressing-T cell, SolidT, enables antibody-mediated cytotoxicity to overcome the limitations of CAR-T cell therapy against solid tumors". Cancer Research 83, № 7_Supplement (2023): 4075. http://dx.doi.org/10.1158/1538-7445.am2023-4075.

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Abstract The pioneering design of chimeric antigen receptor T-cell (CAR-T) therapy demonstrated the potential of reprogramming the immune system. Nonetheless, T-cell exhaustion, toxicity, and suppressive microenvironment limit their efficacy in solid tumors. Recently, we characterized a novel subset of tumor-infiltrating CD4+ T-cells expressing the FcγRI receptor (Rasoulouniriana et al, 2019). Herein we detail the engineering of a novel receptor, based on the FcγRI structure, which is retrovirally transduced into PBMCs (both CD4 and CD8 T-cells). These cells, named SolidT cells, can target tum

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Howard, Caleigh, Shu Wiley, Wenzhao Dong, et al. "Abstract 335: c-KIT targeted ETBs for cancer therapy and HSC transplant conditioning." Cancer Research 82, no. 12_Supplement (2022): 335. http://dx.doi.org/10.1158/1538-7445.am2022-335.

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Abstract Engineered toxin bodies (ETBs) are next-generation immunotoxins that harbor an antibody-derived targeting domain and a cytotoxic payload derived from Shiga-like toxin-1 catalytic subunit A (SLTA). SLTA has been engineered to reduce innate immunogenicity and therefore increase the safety of ETBs whilst retaining potent cytotoxic properties. When targeted via a binding domain, SLTA is internalized and routes to the cytosol leading to irreversible ribosome inactivation and ultimately cell death. ETBs have been developed to treat a wide variety of cancers, including breast, lymphoma, mult

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Terrero, David, Amit Tiwari, and Dayanidhi Raman. "Abstract P1-13-12: Targeting Dynamin-related protein 1 for the management of taxane-resistant triple-negative breast cancer." Cancer Research 83, no. 5_Supplement (2023): P1–13–12—P1–13–12. http://dx.doi.org/10.1158/1538-7445.sabcs22-p1-13-12.

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Abstract The development of drug resistance is a primary cause of chemotherapy failure in the treatment of triple-negative breast cancer (TNBC). Some cancer cells are resistant to drugs with unrelated structures and mechanisms of action, a phenomenon known as multidrug resistance (MDR). Although taxanes such as docetaxel and paclitaxel are effective against non-metastatic and metastatic TNBC and other types of breast cancer, they eventually become ineffective due to development of drug resistance. Mitochondrial dynamics has gained significant attention as a means to treat MDR and non-MDR cance

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Djureinovic, Dijana, Sarah A. Weiss, Irina Krykbaeva, et al. "Abstract 3287: A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better." Cancer Research 83, no. 7_Supplement (2023): 3287. http://dx.doi.org/10.1158/1538-7445.am2023-3287.

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Abstract Stimulating innate immunity can potentially enable us to overcome resistance to PD-(L)1 blockade. We previously conducted a phase 1 trial of cabiralizumab (anti-CSF1R) with sotigalimab (CD40 agonistic antibody) and nivolumab. Our purpose was to determine safety and the effects of this regimen on circulating and tumor-infiltrating immune cells and to determine the activity of this regimen in a phase 1b trial for melanoma patients whose disease had progressed on anti-PD-(L)1. CyTOF analysis on circulating immune cells taken before and during treatment revealed a reduction in non-classic

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Malla, Saloni, David Terrero, Sushma Karki, Mariam Sami Abou-Dahech, Shikha Kumari, and Amit K. Tiwari. "Abstract 1387: Novel thienopyrimidine-hydrazinyl analog, TPH104m inhibits mitochondrial respiration and induces caspase-independent cell death in triple-negative breast cancer cells." Cancer Research 83, no. 7_Supplement (2023): 1387. http://dx.doi.org/10.1158/1538-7445.am2023-1387.

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Abstract A triple negative breast cancer (TNBC) is an aggressive and difficult-to-treat breast cancer subtype. Neoadjuvant chemotherapy using apoptosis-inducing taxanes and/or anthracyclines has been shown to produce early therapeutic responses. Unfortunately, drug resistance often results from mutations in apoptotic pathways, which can lead to metastasis and poor prognosis. There are emerging studies suggesting that TNBC tumors display altered mitochondrial dynamics and have overexpressed dynamin related protein 1 (Drp1), which drives mitochondrial fission. Drp1 deregulation also influences m

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Gera, Nimish, Kyle Fitzgerald, Vijay Ramesh, et al. "Abstract 5000: MYTX-011: A novel cMET-targeting antibody drug conjugate (ADC) engineered to increase on-target uptake in and efficacy against cMET expressing tumors." Cancer Research 83, no. 7_Supplement (2023): 5000. http://dx.doi.org/10.1158/1538-7445.am2023-5000.

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Abstract MET alterations can act as an oncogenic driver in non-small cell lung cancer (NSCLC) and elevated cMET expression occurs in many cancers. Antibody drug conjugates targeting cMET (cMET-ADCs) have been developed as a strategy to treat cMET+ tumors irrespective of dependency on cMET signaling. cMET- ADCs have shown promising clinical activity, but largely in a subset of NSCLC patients having the highest cMET levels, indicating tumor cMET levels may be limiting for efficacy. We sought to create an ADC with the potential to benefit a broader population of patients including those expressin

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Glaun, Mica D. E., Frederico O. Gleber-Netto, Priyadharsini Nagarajan, et al. "Abstract PO-074: The evolution of the tumor immune microenvironment in immunosuppressed patients with cutaneous squamous cell carcinoma." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—074—PO—074. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-074.

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Abstract Immunosuppression is a major risk and prognostic factor for cutaneous squamous cell carcinoma (cSCC). Immune checkpoint inhibition is approved for the treatment of cSCC, yet most immunosuppressed patients are ineligible for immunotherapy. Better understanding on the tumor microenvironment of cSCC in the context of immunosuppression (i.e., organ transplant recipients, patients with hematological malignancies or autoimmune diseases or acquired immunodeficiencies such as HIV) is of utmost importance for proper implementation of immunotherapy as a therapeutic alternative for these patient

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Goyal, Amit, Cydney Bruce, Shabina Sadiq, et al. "Abstract P5-01-07: Recruitment, clinical equipoise, patient acceptance and compliance in the UK-ANZ POSNOC trial." Cancer Research 83, no. 5_Supplement (2023): P5–01–07—P5–01–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-01-07.

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Abstract Background: POSNOC is a UK-ANZ multicentre, non-inferiority, randomised trial comparing systemic therapy alone with systemic therapy plus Axillary Treatment (Axillary radiotherapy or ALND) for women with ≤2 macrometastases at SNB. The primary outcome is axillary recurrence within 5 years. This paper describes screening, recruitment and compliance data. Methods: Sites were requested on a monthly basis to upload screening data and provide reasons for non-recruitment of eligible patients into the trial. Sites entered in the online database whether the patients were compliant with their r

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Yu, Xinheng, Kyle J. Eastman, Kanak Raina, et al. "Abstract 1629: Prostate cancer RIPTAC™ therapeutics demonstrate activity in preclinical models of Enzalutamide-resistant prostate cancer." Cancer Research 83, no. 7_Supplement (2023): 1629. http://dx.doi.org/10.1158/1538-7445.am2023-1629.

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Abstract Background: Novel drugs are needed to tackle forms of prostate cancer that demonstrate resistance to hormonal agents. Halda has invented an innovative cancer treatment approach that does not rely on oncogenic drivers. Regulated Induced Proximity Targeting Chimera (RIPTAC™) therapeutics are heterobifunctional small molecules that work via a hold and kill mechanism that has the potential to overcome drug resistance mechanisms. RIPTAC therapeutics function by holding together two proteins, a cancer-specific protein, and a protein with essential function (EP) in a ternary complex, resulti

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Yao, Shugang, Hiba Zahreddine, Amit Subedi, et al. "Abstract 2931: Functional characterization of KJ-103, a novel therapeutic anti-TROP2 heavy chain-only antibody." Cancer Research 83, no. 7_Supplement (2023): 2931. http://dx.doi.org/10.1158/1538-7445.am2023-2931.

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Abstract Trophoblast cell surface antigen-2 (TROP2) is a membrane-bound protein expressed during development and at lower levels in normal adult tissues. In many solid tumors TROP2 upregulation is associated with increased tumor aggressiveness, metastasis, and decreased survival in difficult-to-treat cancers, making it an attractive target for cancer therapy. TROP2 ADCs have been developed and one has been approved in breast cancer and advanced bladder cancer. The toxicity associated with the toxin payload and the development of resistance to the payload limits their use. We previously describ

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El Hoyek, Elias, Uri Amit, Brent A. Bell, Vivian Lee, Joshua L. Dunaief, and Costantinos Koumenis. "Abstract 1334: FLASH proton radiotherapy mitigates corneal damage and stimulates wound healing in mice." Cancer Research 85, no. 8_Supplement_1 (2025): 1334. https://doi.org/10.1158/1538-7445.am2025-1334.

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Eye cancers are rare but highly aggressive, with significant risk to vision and quality of life. Worldwide, thousands are affected by ocular cancers, which are challenging to treat due to their proximity to sensitive structures. Proton radiotherapy (PRT) is the current gold standard for intraocular tumors due to its precision in limiting RT exposure to surrounding healthy tissue. However, the delicate location restricts the PRT dose that can be safely administered without risking damage to essential orbital structures. FLASH (FR), a novel approach delivering PRT at ultrahigh dose rates (&g

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Kumar, Amit, Padmanabhan Mannangatti, Swadesh K. Das, and Paul B. Fisher. "Abstract 3271: Targeted cancer therapy using a novel recombinant il-24s/il-15 chimeric fusion cytokine." Cancer Research 85, no. 8_Supplement_1 (2025): 3271. https://doi.org/10.1158/1538-7445.am2025-3271.

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Abstract Melanoma Differentiation Associated Gene-7/Interleukin-24 (IL-24) and IL-15 provide therapeutic benefit in treating specific cancers. IL-24 displays cancer-specific apoptosis/toxic autophagy-inducing properties in a broad spectrum of human tumors without harming normal cells. IL-15 induces both differentiation and proliferation of T lymphocyte (T) and natural killer (NK) cells, enhances the cytolytic activity of CD8+ T cells, and induces the maturation of dendritic cells (DCs). In vivo administration of IL-15 has antitumor effects in several mouse tumor models; however, administration

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Melms, Johannes C., Jana Biermann, Amit Dipak Amin, et al. "Abstract 984: Dissecting the ecosystem of treatment-naïve melanoma brain metastasis using multi-modal single-cell analysis." Cancer Research 82, no. 12_Supplement (2022): 984. http://dx.doi.org/10.1158/1538-7445.am2022-984.

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Abstract Brain metastases are the most frequent malignancies in the brain and are associated with significant morbidity and mortality. Melanoma brain metastases (MBM) occur in most patients with advanced melanoma and are challenging to treat. Our understanding of the treatment-naïve landscape of MBM is still rudimentary, and there are no site-specific molecular therapies available. To gain comprehensive insights into the niche-specific biology of MBM, we performed multi-modal profiling of fresh and frozen samples using single-cell RNA-seq, single-cell TCR-seq, single-nuclei RNA-seq, and spatia

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Goyal, Amit, Sophie Nicholls, Andrea Marshall, et al. "Abstract OT1-09-02: ATNEC: A multicentre, randomized trial investigating whether axillary treatment can be avoided in T1-3N1M0 breast cancer patients with no residual cancer in the axillary lymph nodes after neoadjuvant chemotherapy." Cancer Research 83, no. 5_Supplement (2023): OT1–09–02—OT1–09–02. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot1-09-02.

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Abstract Background: For patients who are node positive at presentation and are found to have a complete nodal tumour response (ypN0) post-neoadjuvant chemotherapy (NACT), we do not yet know whether local axillary therapy can be modified based on the response to NACT. ATNEC addresses whether axillary treatment can be de-escalated, post-surgery, in T1-3N1M0 breast cancer patients who have no residual nodal disease post-NACT. Methods: Design: ATNEC is a phase III, randomized (1:1), multi-centre trial, with embedded economic evaluation. Patients with proven axillary node metastases on needle biop

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