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Journal articles on the topic 'Trehalase inhibitors'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Marten, Andrew D., Douglas P. Haslitt, Chad A. Martin, et al. "Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus type 2 replication." PLOS Pathogens 21, no. 5 (2025): e1012795. https://doi.org/10.1371/journal.ppat.1012795.

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Trehalose is a non-reducing disaccharide that is the major sugar found in insect hemolymph fluid. Trehalose provides energy, and promotes growth, metamorphosis, stress recovery, chitin synthesis, and insect flight. Trehalase is the only enzyme responsible for the hydrolysis of trehalose, which makes it an attractive molecular target. Here we show that Aedes aegypti (Aag2) cells express trehalase and that they can grow on trehalose-containing cell culture media. Trehalase activity was confirmed by treating Aag2 cells with trehalase inhibitors, which inhibited conversion of trehalose to glucose

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2

White, Christopher, Deborah B. Lee, and Stephen J. Free. "NEUROSPORA TREHALASE AND ITS STRUCTURAL GENE." Genetics 110, no. 2 (1985): 217–27. http://dx.doi.org/10.1093/genetics/110.2.217.

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ABSTRACT We have isolated Neurospora trehalaseless mutants and mapped the trehalase structural gene to linkage group I. The structural gene mutations not only affect thermostability and other characteristics of the enzyme but also affect the production of an inhibitor of the wild-type trehalase. The inhibitor appears to be the mutant trehalase. We suggest that the mutant subunits act as inhibitors by entering into the multimeric forms of the enzyme and altering the ability of the normal wild-type subunits to catalyze the cleavage of trehalose.—Wild type trehalase has been purified to near homo

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3

Matassini, Camilla, Camilla Parmeggiani, and Francesca Cardona. "New Frontiers on Human Safe Insecticides and Fungicides: An Opinion on Trehalase Inhibitors." Molecules 25, no. 13 (2020): 3013. http://dx.doi.org/10.3390/molecules25133013.

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In the era of green economy, trehalase inhibitors represent a valuable chance to develop non-toxic pesticides, being hydrophilic compounds that do not persist in the environment. The lesson on this topic that we learned from the past can be of great help in the research on new specific green pesticides. This review aims to describe the efforts made in the last 50 years in the evaluation of natural compounds and their analogues as trehalase inhibitors, in view of their potential use as insecticides and fungicides. Specifically, we analyzed trehalase inhibitors based on sugars and sugar mimics,

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4

Marten, Andrew D., Alicyn I. Stothard, Karishma Kalera, Benjamin M. Swarts, and Michael J. Conway. "Validamycin A Delays Development and Prevents Flight in Aedes aegypti (Diptera: Culicidae)." Journal of Medical Entomology 57, no. 4 (2020): 1096–103. http://dx.doi.org/10.1093/jme/tjaa004.

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Abstract Trehalose is a disaccharide that is the major sugar found in insect hemolymph fluid. Trehalose provides energy, and promotes growth, metamorphosis, stress recovery, chitin synthesis, and insect flight. The hydrolysis of trehalose is under the enzymatic control of the enzyme trehalase. Trehalase is critical to the role of trehalose in insect physiology, and is required for the regulation of metabolism and glucose generation. Trehalase inhibitors represent a novel class of insecticides that have not been fully developed. Here, we tested the ability of trehalose analogues to function as

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5

Streeter, J. G., and M. L. Gomez. "Three Enzymes for Trehalose Synthesis in Bradyrhizobium Cultured Bacteria and in Bacteroids from Soybean Nodules." Applied and Environmental Microbiology 72, no. 6 (2006): 4250–55. http://dx.doi.org/10.1128/aem.00256-06.

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ABSTRACT α,α-Trehalose is a disaccharide accumulated by many microorganisms, including rhizobia, and a common role for trehalose is protection of membrane and protein structure during periods of stress, such as desiccation. Cultured Bradyrhizobium japonicum and B. elkanii were found to have three enzymes for trehalose synthesis: trehalose synthase (TS), maltooligosyltrehalose synthase (MOTS), and trehalose-6-phosphate synthetase. The activity level of the latter enzyme was much higher than those of the other two in cultured bacteria, but the reverse was true in bacteroids from nodules. Althoug

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6

Yu, Liuhe, Fan Zhong, Xinyi Jiang, et al. "Effect of Three Novel Thiazolidiones on the Development, Reproduction, and Trehalase Activity of Spodoptera frugiperda (Lepidoptera: Noctuidae)." Agronomy 14, no. 6 (2024): 1315. http://dx.doi.org/10.3390/agronomy14061315.

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Spodoptera frugiperda was used to investigate its role as a trehalase inhibitor of three new thiothiazolidone compounds—6d, 6e, and 6f. The development and reproduction of S. frugiperda were investigated to evaluate the potential of these compounds as a novel pesticide for pest control. Compounds 6d, 6e, and 6f were injected into larvae and female pupae. Molecular changes in trehalose and chitin metabolism genes were monitored. Pupal trehalase activity, the female pupal emergence rate, ovarian development, and SfVg and SfVgR gene expression levels were assessed. The results revealed that all t

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7

Bini, Davide, Francesca Cardona, Matilde Forcella, et al. "Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors." Beilstein Journal of Organic Chemistry 8 (April 5, 2012): 514–21. http://dx.doi.org/10.3762/bjoc.8.58.

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A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases. Compounds 12, 13 and 20 proved to be active against both insect and porcine trehalases with selectivity towards the insect glycosidase, while compounds 10, 14 and 16 behaved as inhibitors only of insect trehalase. Despite the fact that the activity was found in the micromolar range, these findings may help in elucidating the structural features of this class of enzymes of different origin, which are still scarcely characterised.

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8

KAMEDA, YUKIHIKO, NAOKI ASANO, TAKUJI YAMAGUCHI, and KATSUHIKO MATSUI. "Validoxylamines as trehalase inhibitors." Journal of Antibiotics 40, no. 4 (1987): 563–65. http://dx.doi.org/10.7164/antibiotics.40.563.

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9

Kyosseva, S. V., Z. N. Kyossev, and A. D. Elbein. "Inhibitors of Pig Kidney Trehalase." Archives of Biochemistry and Biophysics 316, no. 2 (1995): 821–26. http://dx.doi.org/10.1006/abbi.1995.1110.

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10

QIAN, XUHONG, ZHIBIN LI, ZHI LIU, GONGHUA SONG, and ZHONG LI. "Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors." Journal of Antibiotics 54, no. 12 (2001): 1108–10. http://dx.doi.org/10.7164/antibiotics.54.1108.

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11

Gibson, Robert P, Tracey M Gloster, Shirley Roberts, et al. "Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors." Angewandte Chemie 119, no. 22 (2007): 4193–97. http://dx.doi.org/10.1002/ange.200604825.

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12

Gibson, Robert P, Tracey M Gloster, Shirley Roberts, et al. "Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors." Angewandte Chemie International Edition 46, no. 22 (2007): 4115–19. http://dx.doi.org/10.1002/anie.200604825.

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13

ASANO, NAOKI, MASAYOSHI TAKEUCHI, YUKIHIKO KAMEDA, KATSUHIKO MATSUI, and YOSHIAKI KONO. "Trehalase inhibitors, validoxylamine A and related compounds as insecticides." Journal of Antibiotics 43, no. 6 (1990): 722–26. http://dx.doi.org/10.7164/antibiotics.43.722.

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14

Bansal, Raman, M. A. Rouf Mian, Omprakash Mittapalli, and Andy P. Michel. "Molecular characterization and expression analysis of soluble trehalase gene in Aphis glycines, a migratory pest of soybean." Bulletin of Entomological Research 103, no. 3 (2013): 286–95. http://dx.doi.org/10.1017/s0007485312000697.

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AbstractIn insects, the enzyme trehalase plays a crucial role in energy metabolism, chitin synthesis and possibly during plant–insect interactions. We have characterized a soluble trehalase gene (Tre-1) from cDNA of Aphis glycines, a serious migratory pest of soybean. The full-length cDNA of Tre-1 in A. glycines (AyTre-1) was 2550 bp long with an open reading frame of 1770 bp that encoded for a 589 amino acid residues protein. Sequence assessment and phylogenetic analysis of the putative protein suggested that the selected cDNA belongs to soluble trehalase group. Quantitative PCR (qPCR) analys

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15

Chen, C. C., W. J. Guo, and K. J. Isselbacher. "Rat intestinal trehalase. Studies of the active site." Biochemical Journal 247, no. 3 (1987): 715–24. http://dx.doi.org/10.1042/bj2470715.

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Rat intestinal trehalase was solubilized, purified and reconstituted into proteoliposomes. With octyl glucoside as the solubilizing detergent, the purified protein appeared as a single band on SDS/polyacrylamide-gel electrophoresis with an apparent molecular mass of 67 kDa. Kinetic studies indicated that the active site of this enzyme can be functionally divided into two adjacent regions, namely a binding site (with pKa 4.8) and a catalytic site (with pKa 7.2). Other findings suggested that the catalytic site contains a functional thiol group, which is sensitive to inhibition by N-ethylmaleimi

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16

Cipolla, Laura, Antonella Sgambato, Matilde Forcella, et al. "N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors." Carbohydrate Research 389 (May 2014): 46–49. http://dx.doi.org/10.1016/j.carres.2013.12.025.

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17

Qian, Xuhong, Zhibin Li, Zhi Liu, Gonghua Song, and Zhong Li. "ChemInform Abstract: Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors." ChemInform 33, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.200222126.

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18

Wu, Yan, Shangrong Hu, Qixuan Mao, et al. "The impact of three thioxothiazolidin compounds on trehalase activity and development of Spodoptera frugiperda larvae." PeerJ 12 (October 9, 2024): e18233. http://dx.doi.org/10.7717/peerj.18233.

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Trehalases (TREs), serving as crucial enzymes regulating trehalose and chitin metabolism in insects, represent prime targets for pest control strategies. We investigated the impact of three thioxothiazolidin compounds (1G, 2G, and 11G) on TRE activity and summarized their effects on the growth and development of Spodoptera frugiperda (Lepidoptera, Noctuidae). The experimental larvae of S. frugiperda were injected with the three thioxothiazolidin compounds (1G, 2G, and 11G), while the control group received an equivalent volume of 2% DMSO as a control. All three compounds had a strong effect on

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19

Adedeji, Eunice O., Gbolahan O. Oduselu, Olubanke O. Ogunlana, Segun Fatumo, Rainer Koenig, and Ezekiel Adebiyi. "Anopheles gambiae Trehalase Inhibitors for Malaria Vector Control: A Molecular Docking and Molecular Dynamics Study." Insects 13, no. 11 (2022): 1070. http://dx.doi.org/10.3390/insects13111070.

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Trehalase inhibitors are considered safe alternatives for insecticides and fungicides. However, there are no studies testing these compounds on Anopheles gambiae, a major vector of human malaria. This study predicted the three-dimensional structure of Anopheles gambiae trehalase (AgTre) and identified potential inhibitors using molecular docking and molecular dynamics methods. Robetta server, C-I-TASSER, and I-TASSER were used to predict the protein structure, while the structural assessment was carried out using SWISS-MODEL, ERRAT, and VERIFY3D. Molecular docking and screening of 3022 compoun

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20

Ogawa, Seiichiro, Chikara Uchida, and Yu Yuming. "Synthesis of aminocyclitol moieties of trehalase inhibitors, trehalostatin and trehazolin. Correct structure of the inhibitor." Journal of the Chemical Society, Chemical Communications, no. 12 (1992): 886. http://dx.doi.org/10.1039/c39920000886.

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21

Cendret, V., T. Legigan, A. Mingot та ін. "Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors". Organic & Biomolecular Chemistry 13, № 43 (2015): 10734–44. http://dx.doi.org/10.1039/c5ob01526j.

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22

D'Adamio, Giampiero, Antonella Sgambato, Matilde Forcella, et al. "New synthesis and biological evaluation of uniflorine A derivatives: towards specific insect trehalase inhibitors." Organic & Biomolecular Chemistry 13, no. 3 (2015): 886–92. http://dx.doi.org/10.1039/c4ob02016b.

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23

Fernandez, J., T. Soto, J. Vicente-Soler, J. Cansado, and M. Gacto. "Trehalase activation induced by nutrients and metabolic inhibitors in Zygosaccharomyces rouxii." Mycological Research 100, no. 12 (1996): 1440–44. http://dx.doi.org/10.1016/s0953-7562(96)80075-x.

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24

Bini, Davide, Matilde Forcella, Laura Cipolla, Paola Fusi, Camilla Matassini, and Francesca Cardona. "Synthesis of Novel Iminosugar-Based Trehalase Inhibitors by Cross-Metathesis Reactions." European Journal of Organic Chemistry 2011, no. 20-21 (2011): 3995–4000. http://dx.doi.org/10.1002/ejoc.201100484.

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25

El Nemr, Ahmed, and El Sayed H. El Ashry. "ChemInform Abstract: Potential Trehalase Inhibitors: Syntheses of Trehazolin and Its Analogues." ChemInform 43, no. 4 (2011): no. http://dx.doi.org/10.1002/chin.201204254.

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26

Tatun, Nujira, Tippawan Singtripop, Shingo Osugi, Siriluck Nachiangmai, Masafumi Iwami, and Sho Sakurai. "Possible involvement of proteinaceous and non-proteinaceous trehalase inhibitors in the regulation of hemolymph trehalose concentration in Bombyx mori." Applied Entomology and Zoology 44, no. 1 (2009): 85–94. http://dx.doi.org/10.1303/aez.2009.85.

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27

Yang, Xiaoyue, Yan Shu, Shulin Cao, et al. "Trehalase Inhibitor Validamycin May Have Additional Mechanisms of Toxicology against Rhizoctonia cerealis." Journal of Fungi 9, no. 8 (2023): 846. http://dx.doi.org/10.3390/jof9080846.

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Sharp eyespot is a crucial disease affecting cereal plants, such as bread wheat (Triticum aestivum) and barley (Hordeum vulgare), and is primarily caused by the pathogenic fungus Rhizoctonia cerealis. As disease severity has increased, it has become imperative to find an effective and reasonable control strategy. One such strategy is the use of the trehalose analog, validamycin, which has been shown to have a potent inhibitory effect on several trehalases found in both insects and fungi, and is widely used as a fungicide in agriculture. In this study, we demonstrated that 0.5 μg/mL validamycin

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28

Qian, Xuhong, Zhibin Li, Zhi Liu, Gonghua Song, and Zhong Li. "Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines." Carbohydrate Research 336, no. 1 (2001): 79–82. http://dx.doi.org/10.1016/s0008-6215(01)00126-4.

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29

Ogawa, Seiichiro, and Chikara Uchida. "Synthesis of aminocyclitol moieties of trehalase inhibitors, trehalostatin and trehazolin. Confirmation of the correct structure of the inhibitor." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (1992): 1939. http://dx.doi.org/10.1039/p19920001939.

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30

Li, Ying, Yonghong Xu, Shunjiao Wu, et al. "Validamycin Inhibits the Synthesis and Metabolism of Trehalose and Chitin in the Oriental Fruit Fly, Bactrocera dorsalis (Hendel)." Insects 14, no. 8 (2023): 671. http://dx.doi.org/10.3390/insects14080671.

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The oriental fruit fly, Bactrocera dorsalis (Hendel), is a notorious invasive pest that has raised concerns worldwide. Validamycin has been demonstrated to be a very strong inhibitor against trehalase in a variety of organisms. However, whether validamycin can inhibit trehalase activity to suppress trehalose hydrolysis and affect any other relevant physiological pathways in B. dorsalis remains unknown. In this study, the effects of validamycin injection on the synthesis and metabolism of trehalose and chitin were evaluated. The results show that validamycin injection significantly affected tre

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31

Uchida, Chikara, Tatsuya Yamagishi, and Seiichiro Ogawa. "Total synthesis of the trehalase inhibitors trehalostatin and trehazolin, and of their diastereoisomers. Final structural confirmation of the inhibitor." Journal of the Chemical Society, Perkin Transactions 1, no. 5 (1994): 589. http://dx.doi.org/10.1039/p19940000589.

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32

Kanzaki, Hiroshi, Takafumi Nuhama, Akio Kobayashi, and Kazuyoshi Kawazu. "An Effective Method of Screening Glucose-rich Microbial Culture Filtrates for Insect Trehalase Inhibitors." Bioscience, Biotechnology, and Biochemistry 59, no. 3 (1995): 398–400. http://dx.doi.org/10.1271/bbb.59.398.

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33

OGAWA, S., and C. UCHIDA. "ChemInform Abstract: Synthesis of Aminocyclitol Moieties of Trehalase Inhibitors, Trehalostatin and Trehazolin. Confirmation of the Correct Structure of the Inhibitor." ChemInform 23, no. 49 (2010): no. http://dx.doi.org/10.1002/chin.199249259.

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34

Qian, Xuhong, Zhibin Li, Zhi Liu, Gonghua Song, and Zhong Li. "ChemInform Abstract: Syntheses and Activities as Trehalase Inhibitors of N-Arylglycosylamines Derived from Fluorinated Anilines." ChemInform 33, no. 7 (2010): no. http://dx.doi.org/10.1002/chin.200207217.

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35

Soto, Teresa, Juana Fernandez, Jero Vicente-Soler, Jose Cansado, and Mariano Gacto. "Posttranslational Regulatory Control of Trehalase Induced by Nutrients, Metabolic Inhibitors, and Physical Agents inPachysolen tannophilus." Fungal Genetics and Biology 20, no. 2 (1996): 143–51. http://dx.doi.org/10.1006/fgbi.1996.0029.

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36

UCHIDA, C., T. YAMAGISHI, and S. OGAWA. "ChemInform Abstract: Total Synthesis of the Trehalase Inhibitors Trehalostatin and Trehazolin, and of Their Diastereoisomers. Final Structural Confirmation of the Inhibitor." ChemInform 25, no. 27 (2010): no. http://dx.doi.org/10.1002/chin.199427239.

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37

Park, No-Joong, Hee Kyung Lim, and In Taek Hwang. "An enhanced system to screen trehalase inhibitors using a microplate assay with a housefly enzyme source." Journal of Asia-Pacific Entomology 11, no. 3 (2008): 161–66. http://dx.doi.org/10.1016/j.aspen.2008.07.004.

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38

D’Adamio, Giampiero, Matilde Forcella, Paola Fusi, et al. "Probing the Influence of Linker Length and Flexibility in the Design and Synthesis of New Trehalase Inhibitors." Molecules 23, no. 2 (2018): 436. http://dx.doi.org/10.3390/molecules23020436.

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39

Qian, Xuhong, Zhi Liu, Zhibin Li, Zhong Li, and Gonghua Song. "Synthesis and Quantitative Structure−Activity Relationships of Fluorine-Containing 4,4-Dihydroxylmethyl-2-aryliminooxazo(thiazo)lidines as Trehalase Inhibitors." Journal of Agricultural and Food Chemistry 49, no. 11 (2001): 5279–84. http://dx.doi.org/10.1021/jf010632k.

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40

Basistha, Bipasha, Anil Kumar Ghosh, and Sumita Ghosh. "Regulation of trehalose metabolism by protein methylation in a mutant strain of Saccharomyces cerevisiae." NBU Journal of Plant Sciences 4, no. 1 (2010): 39–45. http://dx.doi.org/10.55734/nbujps.2010.v04i01.007.

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Trechaloseis a non reducing disaccharide occurring in a wide range of organisms, from bacteria, yeast, to lower and higher plants and insects. It is economically important as a potent stress protectant, protein and biological membrane stabilizer: hence biosynthesis of trchalose is an extremely important event. Regulation of trehalose metabolism by protein methylation has been reported from previous works of this laboratory. Trehalose metabolism was monitored during different stages of growth of Saccharomyces cerevisiae. HPLC and enzymatic determination of trehalose. glucose, trehalose 6 phosph

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41

Basistha, Bipasha, Anil Kumar Ghosh, and Sumita Ghosh. "Regulation of trehalose metabolism by protein methylation in a mutant strain of Saccharomyces cerevisiae." NBU Journal of Plant Sciences 4, no. 1 (2010): 39–45. http://dx.doi.org/10.55734/nbujps.2010.v04i01.007.

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Trechaloseis a non reducing disaccharide occurring in a wide range of organisms, from bacteria, yeast, to lower and higher plants and insects. It is economically important as a potent stress protectant, protein and biological membrane stabilizer: hence biosynthesis of trchalose is an extremely important event. Regulation of trehalose metabolism by protein methylation has been reported from previous works of this laboratory. Trehalose metabolism was monitored during different stages of growth of Saccharomyces cerevisiae. HPLC and enzymatic determination of trehalose. glucose, trehalose 6 phosph

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42

Shao, Zuo-min, Jian-hao Ding, De-lei Jiang, et al. "Characterization and Functional Analysis of trehalase Related to Chitin Metabolism in Glyphodes pyloalis Walker (Lepidoptera: Pyralidae)." Insects 12, no. 4 (2021): 370. http://dx.doi.org/10.3390/insects12040370.

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Glyphodes pyloalis Walker (G. pyloalis) is a serious pest on mulberry. Due to the increasing pesticide resistance, the development of new and effective environmental methods to control G. pyloalis is needed. Trehalase is an essential enzyme in trehalose hydrolysis and energy supply, and it has been considered a promising target for insect pest control. However, the specific function of trehalase in G. pyloalis has not been reported. In this study, two trehalase genes (GpTre1 and GpTre2) were identified from our previous transcriptome database. The functions of the trehalase in chitin metabolis

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43

Conway, Michael J., Douglas P. Haslitt, and Benjamin M. Swarts. "Targeting Aedes aegypti Metabolism with Next-Generation Insecticides." Viruses 15, no. 2 (2023): 469. http://dx.doi.org/10.3390/v15020469.

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Aedes aegypti is the primary vector of dengue virus (DENV), zika virus (ZIKV), and other emerging infectious diseases of concern. A key disease mitigation strategy is vector control, which relies heavily on the use of insecticides. The development of insecticide resistance poses a major threat to public health worldwide. Unfortunately, there is a limited number of chemical compounds available for vector control, and these chemicals can have off-target effects that harm invertebrate and vertebrate species. Fundamental basic science research is needed to identify novel molecular targets that can

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44

THEVELEIN, J. M., and M. BEULLENS. "Cyclic AMP and the Stimulation of Trehalase Activity in the Yeast Saccharomyces cerevisiae by Carbon Sources, Nitrogen Sources and Inhibitors of Protein Synthesis." Microbiology 131, no. 12 (1985): 3199–209. http://dx.doi.org/10.1099/00221287-131-12-3199.

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45

Plabutong, Napasawan, Supanuch Ekronarongchai, Nattarika Niwetbowornchai, et al. "The Inhibitory Effect of Validamycin A on Aspergillus flavus." International Journal of Microbiology 2020 (June 27, 2020): 1–12. http://dx.doi.org/10.1155/2020/3972415.

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Aspergillus flavus is one of the most common isolates from patients with fungal infections. Aspergillus infection is usually treated with antifungal agents, but side effects of these agents are common. Trehalase is an essential enzyme involved in fungal metabolism, and the trehalase inhibitor, validamycin A, has been used to prevent fungal infections in agricultural products. In this study, we observed that validamycin A significantly increased trehalose levels in A. flavus conidia and delayed germination, including decreased fungal adherence. In addition, validamycin A and amphotericin B show

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46

Wu, Zhiyuan, Yongjie Zhang, Yuyuan Liu, et al. "Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons." Life 11, no. 9 (2021): 948. http://dx.doi.org/10.3390/life11090948.

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Autophagic/lysosomal dysfunction is a critical pathogenesis of neuronal injury after ischemic stroke. Trehalose has been validated to restore the impaired autophagy flux by boosting transcription factor EB (TFEB) nuclear translocation, but orally administrated trehalose can be greatly digested by intestinal trehalase before entering into brain. Melibiose (MEL), an analogue of trehalose, may thoroughly exert its pharmacological effects through oral administration due to absence of intestinal melibiase. The present study was to investigate whether melibiose could also confer a neuroprotection by

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47

Ogawa, Seiichiro, Koji Sato та Yasunobu Miyamoto. "Synthesis and trehalase-inhibitory activity of an imino-linked dicarba-α,α-trehalose and analogues thereof". J. Chem. Soc., Perkin Trans. 1, № 6 (1993): 691–96. http://dx.doi.org/10.1039/p19930000691.

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48

Uchida, Chikara, Tatsuya Yamagishi, Hideo Kitahashi, Yoko Iwaisaki, and Seiichiro Ogawa. "Further chemical modification of trehalase inhibitor trehazolin: Structure and inhibitory-activity relationship of the inhibitor." Bioorganic & Medicinal Chemistry 3, no. 12 (1995): 1605–24. http://dx.doi.org/10.1016/0968-0896(95)00147-6.

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GLASHEEN, J. S., and STEVEN C. HAND. "Anhydrobiosis in Embryos of the Brine Shrimp Artemia: Characterization of Metabolic Arrest During Reductions in Cell-Associated Water." Journal of Experimental Biology 135, no. 1 (1988): 363–80. http://dx.doi.org/10.1242/jeb.135.1.363.

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Abstract:

Upon entry into the state of anhydrobiosis, trehalose-based energy metabolism is arrested in Artemia embryos (cysts). We have compared changes in the levels of trehalose, glycogen, some glycolytic intermediates and adenylate nucleotides in hydrated embryos observed under conditions of aerobic development with those occurring after transfer to 50moll−1 NaCl. This treatment is known to reduce cellassociated water into a range previously referred to as the ametabolic domain. The trehalose utilization and glycogen synthesis that occur during development of fully hydrated cysts are both blocked dur

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Kono, Y., M. Takahashi, K. Matsushita, and M. Nishina. "Trehalose synthesis in the fat body of Periplaneta americana and effect of a trehalase inhibitor on it." Medical Entomology and Zoology 48, no. 2 (1997): 164. http://dx.doi.org/10.7601/mez.48.164_2.

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