Relevant bibliographies by topics / TREK1

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'TREK1'

Author: Grafiati
Published: 6 September 2023
Last updated: 19 July 2025

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Journal articles on the topic "TREK1"

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Levitz, Joshua, Perrine Royal, Yannick Comoglio, et al. "Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels." Proceedings of the National Academy of Sciences 113, no. 15 (2016): 4194–99. http://dx.doi.org/10.1073/pnas.1522459113.

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Twik-related K+ channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated K+ channel (TRAAK) form the TREK subfamily of two-pore-domain K+ (K2P) channels. Despite sharing up to 78% sequence homology and overlapping expression profiles in the nervous system, these channels show major differences in their regulation by physiological stimuli. For instance, TREK1 is inhibited by external acidification, whereas TREK2 is activated. Here, we investigated the ability of the members of the TREK subfamily to assemble to form functional heteromeric channels with novel properties. Using singl
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Kim, Seong-Seop, Jimin Park, Eunju Kim, Eun Mi Hwang та Jae-Yong Park. "β-COP Suppresses the Surface Expression of the TREK2". Cells 12, № 11 (2023): 1500. http://dx.doi.org/10.3390/cells12111500.

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K2P channels, also known as two-pore domain K+ channels, play a crucial role in maintaining the cell membrane potential and contributing to potassium homeostasis due to their leaky nature. The TREK, or tandem of pore domains in a weak inward rectifying K+ channel (TWIK)-related K+ channel, subfamily within the K2P family consists of mechanical channels regulated by various stimuli and binding proteins. Although TREK1 and TREK2 within the TREK subfamily share many similarities, β-COP, which was previously known to bind to TREK1, exhibits a distinct binding pattern to other members of the TREK s
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Bai, Xilian, George J. Bugg, Susan L. Greenwood, et al. "Expression of TASK and TREK, two-pore domain K+ channels, in human myometrium." Reproduction 129, no. 4 (2005): 525–30. http://dx.doi.org/10.1530/rep.1.00442.

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Two-pore domain K+channels are an emerging family of K+channels that may contribute to setting membrane potential in both electrically excitable and non-excitable cells and, as such, influence cellular function. The human uteroplacental unit contains both excitable (e.g. myometrial) and non-excitable cells, whose function depends upon the activity of K+channels. We have therefore investigated the expression of two members of this family, TWIK (two-pore domain weak inward rectifying K+channel)-related acid-sensitive K+channel (TASK) and TWIK-related K+channel (TREK) in human myometrium. Using R
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Afzali, Ali M., Tobias Ruck, Alexander M. Herrmann, et al. "The potassium channels TASK2 and TREK1 regulate functional differentiation of murine skeletal muscle cells." American Journal of Physiology-Cell Physiology 311, no. 4 (2016): C583—C595. http://dx.doi.org/10.1152/ajpcell.00363.2015.

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Two-pore domain potassium (K2P) channels influence basic cellular parameters such as resting membrane potential, cellular excitability, or intracellular Ca2+-concentration [Ca2+]i. While the physiological importance of K2P channels in different organ systems (e.g., heart, central nervous system, or immune system) has become increasingly clear over the last decade, their expression profile and functional role in skeletal muscle cells (SkMC) remain largely unknown. The mouse SkMC cell line C2C12, wild-type mouse muscle tissue, and primary mouse muscle cells (PMMs) were analyzed using quantitativ
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Blin, Sandy, Ismail Ben Soussia, Eun-Jin Kim, et al. "Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties." Proceedings of the National Academy of Sciences 113, no. 15 (2016): 4200–4205. http://dx.doi.org/10.1073/pnas.1522748113.

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The tandem of pore domain in a weak inwardly rectifying K+ channel (Twik)-related acid-arachidonic activated K+ channel (TRAAK) and Twik-related K+ channels (TREK) 1 and TREK2 are active as homodimers gated by stretch, fatty acids, pH, and G protein-coupled receptors. These two-pore domain potassium (K2P) channels are broadly expressed in the nervous system where they control excitability. TREK/TRAAK KO mice display altered phenotypes related to nociception, neuroprotection afforded by polyunsaturated fatty acids, learning and memory, mood control, and sensitivity to general anesthetics. These
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Hermanstyne, T. O., K. Markowitz, L. Fan, and M. S. Gold. "Mechanotransducers in Rat Pulpal Afferents." Journal of Dental Research 87, no. 9 (2008): 834–38. http://dx.doi.org/10.1177/154405910808700910.

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The hydrodynamic theory suggests that pain associated with stimulation of a sensitive tooth ultimately involves mechanotransduction as a consequence of fluid movement within exposed dentinal tubules. To determine whether putative mechanotransducers could underlie mechanotransduction in pulpal afferents, we used a single-cell PCR approach to screen retrogradely labeled pulpal afferents. The presence of mRNA encoding BNC-1, ASIC3, TRPV4, TRPA1, the α, β, and γ subunits of ENaC, and the two pore K+ channels (TREK1, TREK2) and TRAAK were screened in pulpal neurons from rats with and without pulpal
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Peng, Yuanzhi, Qingqing Zhang, Hao Cheng, Saie Shen, and Xiaojian Weng. "Activation of TREK1 Channel in the Anterior Cingulate Cortex Improves Neuropathic Pain in a Rat Model." Computational Intelligence and Neuroscience 2022 (September 30, 2022): 1–6. http://dx.doi.org/10.1155/2022/1372823.

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Objective. To explore the biological function and mechanism of TREK1 in neuropathic pain. Thirty-two healthy rats and rats with sciatic nerve chronic press-fitting model (chronic constriction injury of the sciatic nerve, CCI) were selected. Western blot, immunofluorescence staining, and patch clamp technique were performed to explore the biological functions of TREK1. The expression of TREK1 was decreased in the CCI model. The TREK1 channel current in the CCI model was decreased. After local administration of TREK1 channel activator in the anterior cingulate cortex area, the pain behavior of C
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Kim, Seong-Seop, Yeonju Bae, Osung Kwon та ін. "β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes". Cells 11, № 20 (2022): 3322. http://dx.doi.org/10.3390/cells11203322.

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Mature astrocytes are characterized by a K+ conductance (passive conductance) that changes with a constant slope with voltage, which is involved in K+ homeostasis in the brain. Recently, we reported that the tandem of pore domains in a weak inward rectifying K+ channel (TWIK1 or KCNK1) and TWIK-related K+ channel 1 (TREK1 or KCNK2) form heterodimeric channels that mediate passive conductance in astrocytes. However, little is known about the binding proteins that regulate the function of the TWIK1/TREK1 heterodimeric channels. Here, we found that β-coat protein (COP) regulated the surface expre
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Royal, Perrine, Pablo Ávalos Prado, Brigitte Wdziekonski, and Guillaume Sandoz. "Canaux potassiques à deux domaines P (K2P) et migraine." Biologie Aujourd'hui 213, no. 1-2 (2019): 51–57. http://dx.doi.org/10.1051/jbio/2019020.

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La migraine est un désordre neurologique qui affecte 15 % de la population mondiale. Les crises migraineuses sont liées, entre autres, à l’hyperexcitabilité électrique des neurones trigéminaux. Leur activité électrique est contrôlée par les canaux potassiques à deux domaines P (K2P) dont l’importance dans l’induction du contrôle de l’excitabilité a récemment été mise en évidence par la découverte d’une version mutée de l’un d’eux TRESK, le mutant TRESK-MT, qui est lié à la migraine. Cette découverte a été controversée à la suite du séquençage d’autres canaux TRESK mutés non fonctionnels qui ne
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Brohawn, Stephen G. "How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2." Annals of the New York Academy of Sciences 1352, no. 1 (2015): 20–32. http://dx.doi.org/10.1111/nyas.12874.

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Dissertations / Theses on the topic "TREK1"

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Walsh, Yvonne. "Pharmacological regulation of TREK1, TREK2 and TRESK two pore domain potassium channels." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/68081/.

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Introduction: Two pore domain potassium (K2P) channels are responsible for background currents that regulate membrane potential and neuronal excitability. Compounds which alter the activity of these channels are predicted to have therapeutic potential in treating CNS disorders. Members of the TREK family of K2P channels (TREK1 and TREK2) have been shown to play an active role in neuroprotection, depression and pain, whilst TRESK, with high expression in sensory neurons, has a role in nociception. Sipatrigine, a neuroprotective agent and a derivative of the anticonvulsant lamotrigine, is a know
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SATO, Jun, Kazue MIZUMURA, Ken TAKAHASHI, Kimiaki KATANOSAKA, and Yasuko KOZAKI. "Increased C-fiber Activities to Cold in Adjuvant-monoarthritic Rats was not Accompanied by Increased Expression of TREK1 and CMR1 mRNAs(RIEM Conference II, 2002)." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2809.

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Dolcemascolo, Axel. "Laser à semi-conducteur pour modéliser et contrôler des cellules et des réseaux excitables." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4208/document.

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Les systèmes « excitables » sont omniprésents dans la nature, le plus paradigmatique d'entre eux étant le neurone, qui répond de façon « tout ou rien » aux perturbations externes. Cette particularité étant clairement établie comme l'un des points clé pour le fonctionnement des systèmes nerveux, son analyse dans des systèmes modèles (mathématiques ou physiques) peut d'une part aider à la compréhension de la dynamique d'ensembles de neurones couplés et d'autre part ouvrir des voies pour un traitement neuromimétique de l'information. C'est dans cette logique que s'inscrit la préparation de cette
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Schön, Anna. "Utopia Trek : utopibegreppets resa genom Star Trek." Thesis, Linköping University, Department of Thematic Studies, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2539.

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<p>Humanity has always dreamed about a better world. These dreams has manifested themselves in the vision of Utopia - the good place, but also the non-existing place. Up until World War II man still wrote optimistic descriptions of this ideal world, and spread the idea through literature. In the aftermath of the atomic bomb and under the influence of the cold war, these publications seized to surface in literary surroundings. Despite this utopia did not die - it has only changed. Today you can find utopia, not primarily in books, but in Science Fiction. TV’s biggest Science Fiction-series, Sta
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Geraghty, Lincoln. "Living with Star Trek : utopia, community, self-improvement and the Star Trek universe." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/10982/.

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Living with Star Trek investigates the connections between Star Trek fandom and the Star Trek text. This study identifies and examines the American themes of utopia, community and self-improvement inherent within the fictional text which also form the thematic framework for letters written by fans to express their affection for the series. These letters represent a `network of support', whereby a community of fans is able to communicate with each other through written correspondence sent to producers, edited collections, and fan magazines. In talking about the series, fans confess and share in
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Valverde, Estrella Lorena. "TREX1 and SAMHD1, and Aicardi-Goutières Syndrome." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291940.

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Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the cerebrospinal fluid. AGS is a heterogenic disease associated with mutations in the gene of the exonuclease TREX1, in any of the genes codifying for the ribonuclease H2, in the phosphohydrolase SAMHD1, in the deaminase ADAR1 or in the cytoplasmic sensor MDA5. The knowledge of these functions is basic for the comprehension of the beginning of the pathogenesis of AGS. In this thesis we focused in the me
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Roy, André 1963. "Une lecture politique de Star trek /." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61800.

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Hawkey, Kate. "Beginning and becoming : a narrative trek." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684911.

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In chapter one I present a history and critique of the articles which comprise my PhD looking at each article in turn. There are two main sets of articles included and I set out how one area of interest developed into the next. The work focuses on the theme of mentoring and then history education. Together they represent my concern with a community of.practice within the history teaching profession. In chapter one I explain the contextual history in the development of my ideas and thinking between the articles and demonstrate how together they form a coherent whole. The chapter is presented as
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Lyons, Reneé C. "Trips and Treks: Teaching Endangered Species Through Literature." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2367.

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Innamaa, Anni. "Expression and function of the two pore potassium (K2P) channels TREK-1, TREK-2 and TASK-3 in ovarian cancer." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606812.

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Aberrant expression of potassium (K+) channels contributes to cancer cell proliferation and in certain circumstances channel blockade has been shown to inhibit cell proliferation. Two pore potassium (K2P) channels are the most recently identified group of K+ channels. K2P channels have been found to play a role in several cancers including prostate and breast cancer. We investigated the K2P channels TREK-1, TREK-2 and TASK-3, in ovarian cancer and normal ovaries and described the effect of channel blockade on cell proliferation, the cell cycle and apoptosis. Immunofluorescence confirmed expres
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Books on the topic "TREK1"

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Paul, Stewart. Trek. Cape, 1991.

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Norris, Dorothy Tinnin. Tinnin treks. D.T. Norris, 1989.

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Dunham, Judith. Backcountry treks. Discovery Communications, 2000.

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Dunham, Judith. Backcountry treks. Discovery Communications, 2000.

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Judith, Dunham, ed. Backcountry treks. Discovery Communications, 2000.

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Merezhkovsky, Dmitry Sergeyevich. Taĭna trekh. Izd-vo "Respublika", 1999.

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London, Jack. Serdt︠s︡a trekh. Folio, 1998.

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Gregory, Chris. Star Trek. Palgrave Macmillan UK, 2000. http://dx.doi.org/10.1057/9780230598409.

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Hark, Ina Rae. Star Trek. British Film Institute, 2008. http://dx.doi.org/10.1007/978-1-349-92226-0.

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Simchenko, I͡Uriĭ Borisovich. Winter trek. Progress Publishers, 1990.

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Book chapters on the topic "TREK1"

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Šiljak, Harun. "Normed Trek." In Murder on the Einstein Express and Other Stories. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29066-9_1.

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Dewdney, Alexander Keewatin. "The Trek." In The Planiverse. Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4613-0199-8_6.

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Tahan, Mary R. "Snow Trek." In Roald Amundsen’s Sled Dogs. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-02692-9_29.

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Hackett, Paul M. W., and Chenwei Li. "Star Trek." In Using Declarative Mapping Sentences in Psychological Research. Routledge, 2022. http://dx.doi.org/10.4324/9781003138419-2.

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Hackett, Paul M. W., and Chenwei Li. "Star Trek." In Using Declarative Mapping Sentences in Psychological Research. Routledge, 2022. http://dx.doi.org/10.4324/9781003138419-5.

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Artzt, Karen, and Jiang I. Wu. "Star Trek." In Advances in Experimental Medicine and Biology. Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7005-3_1.

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Maxwell, Ashley-Marie. "Star Trek." In The Palgrave Encyclopedia of Global Shakespeare. Springer Nature Switzerland, 2024. https://doi.org/10.1007/978-3-319-99378-2_285-1.

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Hark, Ina Rae. "Trekker’s Log, Stardate 1908200.7." In Star Trek. British Film Institute, 2008. http://dx.doi.org/10.1007/978-1-349-92226-0_1.

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Hark, Ina Rae. "Course Plotted and Laid In." In Star Trek. British Film Institute, 2008. http://dx.doi.org/10.1007/978-1-349-92226-0_2.

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Hark, Ina Rae. "Star Trek: This Side of Paradise." In Star Trek. British Film Institute, 2008. http://dx.doi.org/10.1007/978-1-349-92226-0_3.

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Conference papers on the topic "TREK1"

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Fickas, Stephen, McKay Sohlberg, and Jason Prideaux. "TREK." In the 7th international conference. ACM Press, 2008. http://dx.doi.org/10.1145/1463689.1463717.

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Marques, Leonardo, Mauro Amazonas, Thais Castro, et al. "UX trek." In IHC '20: XIX Brazilian Symposium on Human Factors in Computing Systems. ACM, 2020. http://dx.doi.org/10.1145/3424953.3426547.

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Sinnott, Richard O. "Cloud Trek." In UCC '17: 10th International Conference on Utility and Cloud Computing. ACM, 2017. http://dx.doi.org/10.1145/3147213.3155014.

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Horta, Edson, Ho-Ren Chuang, Naarayanan Rao VSathish, et al. "Xar-trek." In Middleware '21: 22nd International Middleware Conference. ACM, 2021. http://dx.doi.org/10.1145/3464298.3493388.

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Balan, V. "CMP-Stack Trek." In 2016 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2016. http://dx.doi.org/10.7567/ssdm.2016.k-2-01.

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Datz, Suzanne. "Star Trek---the experience." In ACM SIGGRAPH 97 Visual Proceedings: The art and interdisciplinary programs of SIGGRAPH '97. ACM Press, 1997. http://dx.doi.org/10.1145/259081.259492.

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Dudak, Celal, Emrah Oncu, Koray Karakus, Neslin Ismailoglu, and Volkan Akan. "Variations on the theme of TREKS-823." In 2013 6th International Conference on Recent Advances in Space Technologies (RAST). IEEE, 2013. http://dx.doi.org/10.1109/rast.2013.6581297.

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Shimizu, Suguru. "Active polarimeter system for TREK experiment." In 2009 KAON International Conference. Sissa Medialab, 2010. http://dx.doi.org/10.22323/1.083.0016.

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Djalali, Chaden, and TREK Collaboration. "The TREK program at J-PARC." In IX LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS. AIP, 2012. http://dx.doi.org/10.1063/1.3688817.

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Kohl, M., and TREK Collaboration. "The TREK/E36 experiment at J-PARC." In WORKSHOP TO EXPLORE PHYSICS OPPORTUNITIES WITH INTENSE, POLARIZED ELECTRON BEAMS AT 50-300 MEV. AIP, 2013. http://dx.doi.org/10.1063/1.4829396.

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Reports on the topic "TREK1"

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Bruce Ohme. Deep Trek High Temperature Electronics Project. Office of Scientific and Technical Information (OSTI), 2007. http://dx.doi.org/10.2172/923033.

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Bruce Ohme and Michael Johnson. Deep Trek Re-configurable Processor for Data Acquisition (RPDA). Office of Scientific and Technical Information (OSTI), 2009. http://dx.doi.org/10.2172/982893.

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Desilets, Y., M. Fafard, M. Lasserre, S. Lebeau, M J Manore, and B. Ramsay. RADARSAT Helps High-Tech Trek to the Magnetic North Pole. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1996. http://dx.doi.org/10.4095/218978.

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Kohl, Michael. Closeout Report - Search for Time Reversal Symmetry Violation with TREK at J-PARC. Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1212319.

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Kevin D. Edgley, Fred L. Sabins, and Larry T. Watters. Supercement for Annular Seal and Long-Term Integrity in Deep, Hot Wells "Deep Trek". Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/908315.

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Huang, Lu, Sisen Zhang, Cancan Wang, and Fengying Wang. Protective Effects of the TREM1 Inhibitor LP17 on Experimental Acute Brain Injury: A protocol for Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.6.0115.

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Frykman, P. N., E. A. Harman, J. F. Patton, P. K. Opstad, and R. W. Hoyt. Effects of a World Record Unsupported Ski Trek Across Greenland (The G2 Expedition) on Physical Performance and Body Composition. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada396385.

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Njå, Ove, and Kirsti Russell Vastveit. Norske kommuners planlegging, gjennomføring og bruk av risiko- og sårbarhetsanalyse i forbindelse med samfunnssikkerhetsarbeidet. University of Stavanger, 2016. http://dx.doi.org/10.31265/usps.164.

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I prosjektet; «Helhetlig ROS-analyse i norske kommuner» analyserer vi hvordan kommuner utvikler, bruker og oppdaterer ROS-analyser og risikoforestillinger i sitt samfunnssikkerhetsarbeid. Det legges vekt på hvordan kommuner integrerer ROS-arbeidet og risikoforestillinger i eksisterende plan- og arbeidsprosesser. Hvilke utfordringer opplever kommunene i dette arbeidet? Etter å ha jobbet med risiko og sikkerhet i mer enn 20 år, og en vesentlig del av disse opp mot kommuner, er det etter vårt syn et gjennomgående trekk at kommunalt ansatte som jobber med sikkerhet og beredskap har stor skepsis ti
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