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Journal articles on the topic 'Treponematoses'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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1

Goyal, S., KK Singal, and B. Singh. "Gummatous ulcer of leg: an uncommon entity in present era." Bangladesh Journal of Medical Science 10, no. 3 (August 15, 2011): 209–10. http://dx.doi.org/10.3329/bjms.v10i3.7514.

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Gummatous ulcer due to Treponematoses is quite rare in present era of potent antibiotics, increased social awareness and due to improvement in living standards of society .Better hygiene and improved medical care have contributed to containment of late benign syphilis or gummas. However, pockets of endemic treponematoses is still persisting in the underdeveloped, third world countries.Key words: Gummatous ulcer, treponematoses, antibiotics.DOI: http://dx.doi.org/10.3329/bjms.v10i3.7514BJMS 2011; 10(3): 209-210

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2

Engelkens, Herman Jan H., Jubianto Judanarso, Arnold P. Oranje, Vojislav D. Vuzevski, Paul L. A. Niemel, Jaap J. Sluis, and Ernst Stolz. "Endemic Treponematoses." International Journal of Dermatology 30, no. 2 (February 1991): 77–83. http://dx.doi.org/10.1111/j.1365-4362.1991.tb04215.x.

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3

Engelkens, Herman Jan H., Paul L. A. Niemel, Jaap J. Sluis, André Meheus, and Ernst Stolz. "Endemic Treponematoses." International Journal of Dermatology 30, no. 4 (April 1991): 231–38. http://dx.doi.org/10.1111/j.1365-4362.1991.tb04626.x.

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4

de Schryver, Antoon, and Andre Meheus. "Le Nouveau Visage D’une Vieille Maladie." Afrika Focus 4, no. 3-4 (January 15, 1988): 101–18. http://dx.doi.org/10.1163/2031356x-0040304003.

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New Aspects of an Old Disease. Pian, Endemic Syphilis and Pinta: The Endemic Treponematoses Yaws and the other endemic treponematoses (bejel or endemic syphilis, pinta) are resurging in many countries of Africa. Today there are more than 2.5 million cases of these diseases, 75% of them in children. More than 100 million additional children are at risk to these disabling and disfiguring infections which destroy tissue and bone. In the 1950’s and 1960’s, through concerted efforts and leadership of UNICEF and WHO, more than 50 million individuals in 46 countries were cured and the diseases were brought under control or even eliminated from large parts of the world. Despite this success, endemic foci remained and in the last ten years there has been an alarming resurgence of the endemic treponematoses, in particular in parts of West and Central Africa. Endemic treponematoses control is based on treatment with single-dose penicillin of the entire treponemal reservoir, and of all clinical cases and their contacts presumed to be incubating the disease. No instances of penicillin-resistance have been documented to date and these infections should be eliminated while the organisms still remain sensitive to penicillin. An endemic treponematoses control programme must be fully integrated into the primary health care system. The persistence of endemic treponematoses in an area is an indicator of failing effectiveness of primary health care. From recent consultations with Member States, WHO Collaborating Centres and expert groups, a consensus regarding the fundamental components of endemic treponematoses control has emerged. Effective disease control requires coordinated and complementary activities by WHO and Member States. The interruption of disease transmission is a feasible and realistic objective for renewed control programmes.

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5

Giacani, L., and S. A. Lukehart. "The Endemic Treponematoses." Clinical Microbiology Reviews 27, no. 1 (January 1, 2014): 89–115. http://dx.doi.org/10.1128/cmr.00070-13.

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6

Meheus, André. "Non-venereal treponematoses." Medicine 33, no. 10 (October 2005): 82–84. http://dx.doi.org/10.1383/medc.2005.33.10.82.

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7

Meheus, Andre. "Non-venereal Treponematoses." Medicine 29, no. 8 (August 2001): 78–81. http://dx.doi.org/10.1383/medc.29.8.78.28397.

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8

Antal, Georg Michael, Sheila A. Lukehart, and André Z. Meheus. "The endemic treponematoses." Microbes and Infection 4, no. 1 (January 2002): 83–94. http://dx.doi.org/10.1016/s1286-4579(01)01513-1.

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9

Jung, Rodney C. "Handbook of Endemic Treponematoses." American Journal of Tropical Medicine and Hygiene 34, no. 6 (November 1, 1985): 1234. http://dx.doi.org/10.4269/ajtmh.1985.34.1234.

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10

Rothschild, B. M. "Treponematoses and the New World." American Journal of Roentgenology 173, no. 4 (October 1999): 1133–34. http://dx.doi.org/10.2214/ajr.173.4.10511198.

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11

Antal, G. M., and G. Causse. "The Control of Endemic Treponematoses." Clinical Infectious Diseases 7, Supplement_2 (May 1, 1985): S220. http://dx.doi.org/10.1093/clinids/7-supplement_2.s220.

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12

Mohamed, Haidar Abu Ahmed. "Endemic Treponematoses in the Sudan." Clinical Infectious Diseases 7, Supplement_2 (May 1, 1985): S239—S241. http://dx.doi.org/10.1093/clinids/7-supplement_2.s239.

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13

Rodgers-Johnson, Pamela, OWENSTC Morgan, Vladimir Zaninovic, D. Carleton Gajdusek, RalphM Garruto, SandraA Larsen, and DanielS Graham. "TREPONEMATOSES AND TROPICAL SPASTIC PARAPARESIS." Lancet 327, no. 8484 (April 1986): 809. http://dx.doi.org/10.1016/s0140-6736(86)91826-x.

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14

Engelkens, H. "Nonvenereal treponematoses in tropical countries." Clinics in Dermatology 17, no. 2 (March 4, 1999): 143–52. http://dx.doi.org/10.1016/s0738-081x(99)00007-3.

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15

Stewart, Antony Dalziel McNeil. "An imperial laboratory: the investigation and treatment of treponematoses in occupied Haiti, 1915-1934." História, Ciências, Saúde-Manguinhos 24, no. 4 (October 2017): 1089–106. http://dx.doi.org/10.1590/s0104-59702017000500013.

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This article examines anti-treponematoses work as part of US occupation public health policy in Haiti, a unique event in the history of international health. Yaws was highly prevalent in Haiti, but occupation doctors initially ignored it because of its close association with syphilis and stigmas attached to sexually transmitted disease. This changed when C.S. Butler asserted that yaws was “innocent” and that the two diseases should therefore be considered as one. Treatment increased as an anti-treponematoses campaign was now believed to hold great benefits for the occupation’s paternalist and strategic aims, even though it ultimately failed. This work reflected Haiti’s status as a public health “laboratory” which affected Haitian medicine for years to come and significantly influenced future campaigns aimed at disease eradication.

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16

Moloney, Mairead, Rebeca Teplitz, Brian How, and Suzanne Sirota-Rozenberg. "A Suspected Case of Imported Yaws in New York." SKIN The Journal of Cutaneous Medicine 7, no. 4 (July 17, 2023): 906–10. http://dx.doi.org/10.25251/skin.7.4.10.

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Introduction: Yaws is an endemic non-venereal treponematoses, which is caused by Treponema pallidum, subspecies pertenue and is spread from person-to-person through direct skin contact with an infected lesion. Yaws causes a chronic skin infection that is characterized by papillomas and ulcers and if left untreated can be disfiguring and debilitating. Cases typically occur in warm, humid, tropical climates and cases are commonly seen in children under 15 years old. However, due to migration, cases can be seen outside of its endemic region. Case Description: We present a case of a 39-year-old African American male who presented with painless bilateral ulcers on his dorsal feet that began as blisters approximately 1-2 weeks prior to presentation at our clinic. Our patient had recent travel history to Jamaica and reported potential sources of trauma to his feet by walking barefoot on the beach and roofing in sandals prior to onset. These findings led to the clinical diagnosis of Yaws. A regimen of azithromycin and basic wound care led to significant improvement. Discussion: Non-venereal endemic treponematoses, such as Yaws, are typically not seen outside of their endemic region. However, due to migration and the ease of travel non-venereal endemic treponematoses can be found elsewhere and it is important for healthcare workers to keep these diseases on their differential, especially in a patient with travel history. After making the diagnosis of Yaws, proper treatment and basic wound care can result in rapid significant improvement and prevent the progression of Yaws lesions to the subsequent stage.

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17

Willcox, R. R. "Mass Treatment Campaigns Against the Endemic Treponematoses." Clinical Infectious Diseases 7, Supplement_2 (May 1, 1985): S278—S283. http://dx.doi.org/10.1093/clinids/7-supplement_2.s278.

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18

Falabella, Rafael. "Nonvenereal treponematoses: Yaws, endemic syphilis, and pinta." Journal of the American Academy of Dermatology 31, no. 6 (December 1994): 1075. http://dx.doi.org/10.1016/s0190-9622(09)80094-7.

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19

Koff, Amy Beth, and Theodore Rosen. "Nonvenereal treponematoses: Yaws, endemic syphilis, and pinta." Journal of the American Academy of Dermatology 29, no. 4 (October 1993): 519–35. http://dx.doi.org/10.1016/0190-9622(93)70217-h.

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20

Kestelyn, Philippe. "Venereal and Endemic Treponematoses in the Developing World." International Ophthalmology Clinics 50, no. 2 (2010): 41–55. http://dx.doi.org/10.1097/iio.0b013e3181d2cdde.

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21

Rothschild, B. M., and C. Rothschild. "Treponematoses — Origins and 1.5 million years of transition." Human Evolution 11, no. 3-4 (July 1996): 225–31. http://dx.doi.org/10.1007/bf02436626.

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22

Touré, Isak M. "Endemic Treponematoses in Togo and Other West African States." Clinical Infectious Diseases 7, Supplement_2 (May 1, 1985): S242—S244. http://dx.doi.org/10.1093/clinids/7-supplement_2.s242.

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23

Harper, Kristin N., Paolo S. Ocampo, Bret M. Steiner, Robert W. George, Michael S. Silverman, Shelly Bolotin, Allan Pillay, Nigel J. Saunders, and George J. Armelagos. "On the Origin of the Treponematoses: A Phylogenetic Approach." PLoS Neglected Tropical Diseases 2, no. 1 (January 15, 2008): e148. http://dx.doi.org/10.1371/journal.pntd.0000148.

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24

NSANZE, HERBERT, GILES G. LESTRINGANT, ABDUL M. AMEEN, JEAN MARIE LAMBERT, IBRAHIM GALADARI, and MOHAMMED A. USMANI. "SEROLOGIC TESTS FOR TREPONEMATOSES IN THE UNITED ARAB EMIRATES." International Journal of Dermatology 35, no. 11 (November 1996): 800–801. http://dx.doi.org/10.1111/j.1365-4362.1996.tb02978.x.

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25

Boaitey, Yaw Agyekum, Alex Owusu-Ofori, Amarachukwu Anyogu, Farhang Aghakhanian, Natasha Arora, Jonathan B. Parr, Philipp P. Bosshard, Saki Raheem, and Pascale Gerbault. "Prevalence of yaws and syphilis in the Ashanti region of Ghana and occurrence of H. ducreyi, herpes simplex virus 1 and herpes simplex virus 2 in skin lesions associated with treponematoses." PLOS ONE 19, no. 5 (May 22, 2024): e0295088. http://dx.doi.org/10.1371/journal.pone.0295088.

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Yaws affects children in tropical regions, while syphilis primarily affects sexually active adults worldwide. Despite various campaigns towards the eradication of yaws and elimination of syphilis, these two diseases are still present in Ghana. The aetiological agents of both diseases, two Treponema pallidum subspecies, are genetically similar. This study aimed to assess the prevalence of these treponematoses and the occurrence of pathogens causing similar skin lesions in the Ashanti region of Ghana. A point-of-care test was used to determine the seroprevalence of the treponematoses. Both yaws and syphilis were identified in the Ashanti region of Ghana. Multiplex PCR was used to identify treponemes and other pathogens that cause similar skin lesions. The results indicated that the seroprevalences of T. pallidum in individuals with yaws-like and syphilis-like lesions were 17.2% and 10.8%, respectively. Multiplex PCR results showed that 9.1%, 1.8% and 0.9% of yaws-like lesions were positive for Haemophilus ducreyi, herpes simplex virus-1 (HSV-1) and T. pallidum respectively. Among syphilis-like lesions, 28.3% were positive for herpes simplex virus -2 (HSV-2) by PCR. To our knowledge, this is the first time HSV-I and HSV-2 have been reported from yaws-like and syphilis-like lesions, respectively, in Ghana. The presence of other organisms apart from T. pallidum in yaws-like and syphilis-like lesions could impede the total healing of these lesions and the full recovery of patients. This may complicate efforts to achieve yaws eradication by 2030 and the elimination of syphilis and warrants updated empirical treatment guidelines for skin ulcer diseases.

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26

Mitjà, Oriol, David Šmajs, and Quique Bassat. "Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta." PLoS Neglected Tropical Diseases 7, no. 10 (October 24, 2013): e2283. http://dx.doi.org/10.1371/journal.pntd.0002283.

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27

Waugh, Michael. "International Union against the Venereal Diseases and the Treponematoses: An Overview." International Journal of STD & AIDS 6, no. 1 (January 1995): 62–63. http://dx.doi.org/10.1177/095646249500600118.

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28

Catterall, R. D. "Symposium on yaws and other endemic treponematoses: Report of a symposium on yaws and other endemic treponematoses held at Washington, DC on 16-18 April 1984." Sexually Transmitted Infections 61, no. 1 (February 1, 1985): 64–65. http://dx.doi.org/10.1136/sti.61.1.64.

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29

Muniz, Érico Silva. "'Basta aplicar uma injeção?': concepções de saúde, higiene e nutrição no Programa de Erradicação da Bouba no Brasil, 1956-1961." História, Ciências, Saúde-Manguinhos 19, no. 1 (March 2012): 197–216. http://dx.doi.org/10.1590/s0104-59702012000100011.

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Analisa o Programa de Erradicação da Bouba, desenvolvido no Brasil entre 1956 e 1961. Após a Segunda Guerra Mundial, durante a qual iniciou-se o uso de antibióticos, um novo método parecia possibilitar a erradicação de treponematoses em curto prazo: a aplicação de injeções de penicilina em dose única. Sob o clima de valorização do controle das endemias rurais no país, a organização de uma campanha contra a bouba tornou-se possível. Os trabalhos, realizados pelo Departamento Nacional de Endemias Rurais, encontraram uma população desnutrida e faminta, o que colocou em dúvida as pretensões da campanha e as concepções de saúde e desenvolvimento da época.

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30

Marks, Michael. "Advances in the Treatment of Yaws." Tropical Medicine and Infectious Disease 3, no. 3 (August 29, 2018): 92. http://dx.doi.org/10.3390/tropicalmed3030092.

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Yaws is one of the three endemic treponematoses and is recognised by the World Health Organization as a neglected tropical disease. Yaws is currently reported in 15 countries in the Pacific, South-East Asia, West and Central Africa, predominantly affects children, and results in destructive lesions of the skin and soft tissues. For most of the twentieth century penicillin-based treatment was the standard of care and resistance to penicillin has still not been described. Recently, oral azithromycin has been shown to be an effective treatment for yaws, facilitating renewed yaws eradication efforts. Resistance to azithromycin is an emerging threat and close surveillance will be required as yaws eradication efforts are scaled up globally.

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31

Henneberg, Maciej, Kara Holloway-Kew, and Teghan Lucas. "Human major infections: Tuberculosis, treponematoses, leprosy—A paleopathological perspective of their evolution." PLOS ONE 16, no. 2 (February 25, 2021): e0243687. http://dx.doi.org/10.1371/journal.pone.0243687.

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The key to evolution is reproduction. Pathogens can either kill the human host or can invade the host without causing death, thus ensuring their own survival, reproduction and spread. Tuberculosis, treponematoses and leprosy are widespread chronic infectious diseases whereby the host is not immediately killed. These diseases are examples of the co-evolution of host and pathogen. They can be well studied as the paleopathological record is extensive, spanning over 200 human generations. The paleopathology of each disease has been well documented in the form of published synthetic analyses recording each known case and case frequencies in the samples they were derived from. Here the data from these synthetic analyses were re-analysed to show changes in the prevalence of each disease over time. A total of 69,379 skeletons are included in this study. There was ultimately a decline in the prevalence of each disease over time, this decline was statistically significant (Chi-squared, p<0.001). A trend may start with the increase in the disease’s prevalence before the prevalence declines, in tuberculosis the decline is monotonic. Increase in skeletal changes resulting from the respective diseases appears in the initial period of host-disease contact, followed by a decline resulting from co-adaptation that is mutually beneficial for the disease (spread and maintenance of pathogen) and host (less pathological reactions to the infection). Eventually either the host may become immune or tolerant, or the pathogen tends to be commensalic rather than parasitic.

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32

Waugh, M. A. "The Bulletin of the International Union Against the Venereal Diseases and Treponematoses." Sexually Transmitted Infections 66, no. 1 (February 1, 1990): 41–42. http://dx.doi.org/10.1136/sti.66.1.41.

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33

Guedes, Lucélia, Ondemar Dias, Jandira Neto, Laura da Piedade Ribeiro da Silva, Sheila M. F. Mendonça de Souza, and Alena Mayo Iñiguez. "First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period." BioMed Research International 2018 (October 10, 2018): 1–8. http://dx.doi.org/10.1155/2018/8304129.

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Despite interest in the origins of syphilis, paleopathological analysis has not provided answers, and paleogenetic diagnosis remains a challenge. Even venereal syphilis has low infectivity which means there are few circulating bacteria for most of the individual’s life. Human remains recovered from the Nossa Senhora do Carmo Church (17th to 19th centuries) and the Praça XV Cemetery (18th to 19th centuries), Rio de Janeiro, Brazil, were subjected toTreponemapaleogenetic analysis. Historical data point to endemic treponemal infections in the city, including venereal syphilis. Based on the physiopathology ofTreponema palliduminfection, 25 samples, mostly from skull remains of young adults, with no visible paleopathological evidence of treponematoses, were analyzed. PCR with three molecular targets,tpp47,polA, andtpp15, were applied. Ancient DNAtpp15 sequences were recovered from two young adults from each archaeological site and revealed the polymorphism that characterizesT. p.subsp.pallidumin a female up to 18 years old, suggesting a probable case of syphilis infection. The results indicated that the epidemiological context and the physiopathology of the disease should be considered in syphilis paleogenetic detection. The findings ofTreponemasp. aDNA are consistent with historical documents that describe venereal syphilis and yaws as endemic diseases in Rio de Janeiro. Data on the epidemiological characteristics of the disease and its pathophysiology offer new perspectives in paleopathology.

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34

Wong, T. W. "WHO Expert Committee on Venereal Diseases and Treponematoses (Sixth Report) Technical Report Series 736." Asia Pacific Journal of Public Health 1, no. 1 (January 1987): 97–98. http://dx.doi.org/10.1177/101053958700100122.

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35

Brown, Stuart T. "Therapy for Nonvenereal Treponematoses: Review of the Efficacy of Penicillin and Consideration of Alternatives." Clinical Infectious Diseases 7, Supplement_2 (May 1, 1985): S318—S326. http://dx.doi.org/10.1093/clinids/7-supplement_2.s318.

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36

Hopkins, Donald R. "Control of Yaws and Other Endemic Treponematoses: Implementation of Vertical and/or Integrated Programs." Clinical Infectious Diseases 7, Supplement_2 (May 1, 1985): S338—S342. http://dx.doi.org/10.1093/clinids/7-supplement_2.s338.

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37

Rothschild, Bruce M., and Christine Rothschild. "Skeletal examination-based recognition of treponematoses: a four continent odyssey of denouement, transition and spread." Bulletins et Mémoires de la Société d'anthropologie de Paris 10, no. 1 (1998): 29–40. http://dx.doi.org/10.3406/bmsap.1998.2500.

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38

Drusin, Lew M. "Report of the Regional Director for North America, International Union against the Venereal Diseases and Treponematoses." International Journal of STD & AIDS 6, no. 1 (January 1995): 63–65. http://dx.doi.org/10.1177/095646249500600119.

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39

Rosa, Sérgio, Fernando Robles Henriques, Telmo António, and Francisco Curate. "Um possível caso de sífilis adquirida num esqueleto oriundo da Ermida do Espírito Santo (séculos XV–XIX, Almada, Portugal)." Antropologia Portuguesa, no. 35 (January 15, 2019): 83–96. http://dx.doi.org/10.14195/2182-7982_35_5.

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A Ermida do Espírito Santo, em Almada, foi provavelmente fundada durante os séculos XIV ou XV mas, após o Terramoto de 1755 — e até finais do século XVIII — serviu como sede da freguesia de Santa Maria do Castelo, período durante o qual foi amplamente utilizada como espaço sepulcral. No decurso da escavação arqueológica prévia ao início das obras de requalificação da Ermida foram recuperados os restos esqueléticos de 88 indivíduos. Neste trabalho apresentam-se as lesões ósseas num indivíduo adulto do sexo feminino que configuram, de forma mais provável, um diagnóstico de sífilis venérea. Desse modo, releva-se a presença de um pequeno foco de caries sicca na região direita do frontal — este tipo de lesão gomatosa é considerado patognomónico em paleopatologia. O frontal (junto à órbita direita) e os zigomáticos apresentam microporosidade e neoformação óssea. O úmero e o fémur direitos, bem como a tíbia e a clavícula esquerdas, exibem periostites e osteítes, com espessamento diafisário extenso. As lesões observadas não são bilaterais, exceto no caso dos malares. Para além da sífilis adquirida, outras opções diagnósticas são consideradas, designadamente outras treponematoses, no contexto histórico da Ermida do Espírito Santo.

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40

Klouman, E., E. J. Masenga, and N. E. Sam. "Serological markers for treponemal infection in children in rural Kilimanjaro, Tanzania: evidence of syphilis or non-venereal treponematoses?" Sexually Transmitted Infections 73, no. 6 (December 1, 1997): 522–27. http://dx.doi.org/10.1136/sti.73.6.522.

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41

Catterall, R. D. "International conjoint STD meeting and 32nd General Assembly of the International Union against the Venereal Diseases and Treponematoses." Sexually Transmitted Infections 61, no. 3 (June 1, 1985): 208. http://dx.doi.org/10.1136/sti.61.3.208.

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42

Waugh, M. A. "International Union against the Venereal Diseases and Treponematoses: Report of the 33rd General Assembly, Paris, 27 June 1986." Sexually Transmitted Infections 63, no. 2 (April 1, 1987): 135. http://dx.doi.org/10.1136/sti.63.2.135.

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43

Maw, R. "The International Union against the Venereal Diseases and the Treponematoses (IUVDT) World STD/AIDS Congress March 19–23, 1995, Singapore." Journal of the European Academy of Dermatology and Venereology 5, no. 1 (August 1995): 77–79. http://dx.doi.org/10.1016/0926-9959(95)00065-l.

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44

Ndzomo Ngono, Jean-Philippe, Serges Tchatchouang, Mireille Victorine Noah Tsanga, Earnest Njih Tabah, Albert Tchualeu, Kingsley Asiedu, Lorenzo Giacani, Sara Eyangoh, and Tania Crucitti. "Ulcerative skin lesions among children in Cameroon: It is not always Yaws." PLOS Neglected Tropical Diseases 15, no. 2 (February 16, 2021): e0009180. http://dx.doi.org/10.1371/journal.pntd.0009180.

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Outbreaks of yaws-like ulcerative skin lesions in children are frequently reported in tropical and sub-tropical countries. The origin of these lesions might be primarily traumatic or infectious; in the latter case, Treponema pallidum subspecies pertenue, the yaws agent, and Haemophilus ducreyi, the agent of chancroid, are two of the pathogens commonly associated with the aetiology of skin ulcers. In this work, we investigated the presence of T. p. pertenue and H. ducreyi DNA in skin ulcers in children living in yaws-endemic regions in Cameroon. Skin lesion swabs were collected from children presenting with yaws-suspected skin lesions during three outbreaks, two of which occurred in 2017 and one in 2019. DNA extracted from the swabs was used to amplify three target genes: the human β2-microglobulin gene to confirm proper sample collection and DNA extraction, the polA gene, highly conserved among all subspecies of T. pallidum, and the hddA gene of H. ducreyi. A fourth target, the tprL gene was used to differentiate T. p. pertenue from the other agents of human treponematoses in polA-positive samples. A total of 112 samples were analysed in this study. One sample, negative for β2-microglobulin, was excluded from further analysis. T. p. pertenue was only detected in the samples collected during the first 2017 outbreak (12/74, 16.2%). In contrast, H. ducreyi DNA could be amplified from samples from all three outbreaks (outbreak 1: 27/74, 36.5%; outbreak 2: 17/24, 70.8%; outbreak 3: 11/13, 84.6%). Our results show that H. ducreyi was more frequently associated to skin lesions in the examined children than T. p. pertenue, but also that yaws is still present in Cameroon. These findings strongly advocate for a continuous effort to determine the aetiology of ulcerative skin lesions during these recurring outbreaks, and to inform the planned mass treatment campaigns to eliminate yaws in Cameroon.

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Langendorf, Céline, Céline Lastrucci, Isabelle Sanou-Bicaba, Kara Blackburn, Marie-Hortense Koudika, and Tania Crucitti. "Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso." Sexually Transmitted Infections 95, no. 6 (December 22, 2018): 402–4. http://dx.doi.org/10.1136/sextrans-2018-053722.

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ObjectivesIn resource-limited settings, screening pregnant women for syphilis using rapid diagnostic tests (RDTs) is a key tool in the prevention of congenital syphilis. However, most syphilis RDTs detect only treponemal antibodies (T-RDT), meaning antibiotics may be provided unnecessarily to previously treated pregnant women, particularly in non-venereal treponematoses endemic regions. We estimated the potential reduction in overtreatment when comparing T-RDT (SD Bioline) to a newer rapid test (Dual Path Platform (DPP) Screen and Confirm Assay, Chembio) detecting both treponemal and non-treponemal antibodies.MethodsPregnant women in Déou, Burkina Faso, screened for syphilis during antenatal care (ANC) visits were prospectively enrolled in the study after providing consent. DPP and T-RDT tests were performed on whole blood specimens. Plasma was tested in an international reference laboratory by Treponema pallidum passive particle agglutination (TPPA) and quantitative rapid plasma reagin (RPR). Presumptive active syphilis was defined as a result that was both TPPA and RPR reactive.ResultsOf the 242 pregnant women included in the study, 91 (37.6%) had presumptive active syphilis and 19.0% had RPR titres ≥8. DPP testing did not reduce the number of pregnant women who would have been overtreated compared with T-RDT (0.0% vs 2.5%; p=0.218) and had a higher proportion of underdiagnosis (48.4% vs 2.2%; p<0.001). Seven women with high RPR titres ≥8 would not have received treatment had only DPP testing been used.ConclusionIn the first evaluation comparing DPP with traditional screening methods in pregnant women, we saw no reduction in unnecessarily treated syphilis and an underestimation of those needing treatment. High seroprevalence in the population may indicate the presence of other treponemal infections in the area, and further study of DPP in a variety of Sahelian and other contexts is warranted.

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Castro, Luiz G. M. "Nonvenereal treponematosis." Journal of the American Academy of Dermatology 31, no. 6 (December 1994): 1075–76. http://dx.doi.org/10.1016/s0190-9622(09)80096-0.

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Ramírez-Pio, Francisco, José Vicente Rodríguez-Cuenca, and Bibiana Cadena-Duarte. "Consideraciones sobre la treponematosis venérea en tiempos prehispánicos e históricos en la región del bajo Magdalena, noroccidente de Suramérica." Revista de Antropología y Sociología : Virajes 26, no. 1 (January 24, 2024): 61–84. http://dx.doi.org/10.17151/rasv.2024.26.1.3.

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Las treponematosis son un conjunto de enfermedades infecciosas producidas por espiroquetas, unas afectan a poblaciones donde son endémicas como es el caso del Pian o el Bejel, que se asocian con deficiencias sanitarias, mientras que otras son de origen venéreo como la sífilis (OMS, 2023). En América, la existencia de estas dolencias se ha documentado desde tiempos precerámicos y en hallazgos arqueológicos recientes en las llanuras del Caribe colombiano se evidenció un caso probable de enfermedad luética. La presente investigación buscó explorar el comportamiento de las treponematosis en el bajo Magdalena desde tiempos prehispánicos hasta el periodo colonial (Sig VIII d.C. – XVII). En este estudio, se analizaron sistemáticamente 67 individuos provenientes de los sitios arqueológicos Turbana, Samán Norte, Plan Bonito, Simití, El Salado, La Pasión y Carmen de Bolívar, siguiendo los criterios planteados por Steckel et al. (2006), Rothschild y Rothschild (1995) y Rodríguez (2005). Se encontró que el 16,41% de los individuos analizados, presentaron afectación por goma, que es una característica de la presencia de treponema en etapa terciaria y justamente el caso con mayor afectación y con alta probabilidad de haber padecido la enfermedad por largo tiempo. Estos resultados nos invitan a hacer varias consideraciones sobre la aproximación diagnóstica a la treponematosis venérea, a ponderar los determinantes involucrados en la prevalencia de la enfermedad en la región a lo largo del tiempo, a la vez que reflexionar alrededor de las estrategias de cuidado y el comportamiento sexual de estas poblaciones.

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Stingl, Peter. "Die Wiederkehr der tropischen Treponematosen." Flugmedizin · Tropenmedizin · Reisemedizin - FTR 28, no. 01 (February 2021): 25–27. http://dx.doi.org/10.1055/a-1253-9954.

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ZUSAMMENFASSUNGNach erfolgreicher Massenbekämpfung in den 1950er und 1960er Jahren ist eine Wiederkehr endemischer Herde der tropischen Treponematosen zu beobachten. Kenntnisse für in den Tropen tätige Ärzte sind daher erforderlich. Es werden die 3 vorkommenden Krankheitssyndrome Frambösie, endemische Syphilis und Pinta vorgestellt. V. a. die Frambösie ist bei nach Europa einwandernden Kindern aus Endemiezonen in die Differenzialdiagnose von Haut - , Schleimhaut – und Knochenpathologien miteinzubeziehen. Und dies unter Beachtung der oft langen, klinisch teils stummen Latenzzeiten zwischen den Krankheitsstadien. Unbehandelt können ernste, irreversible Körperentstellungen folgen.

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Banal, F., A. R. Ndiaye, and D. Lechevalier. "Afectación osteoarticular en las treponematosis." EMC - Aparato Locomotor 43, no. 3 (January 2010): 1–8. http://dx.doi.org/10.1016/s1286-935x(10)70868-6.

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Bialé, L., C. Glanowski, C. Jamakorzyan, and F. Banal. "Afectaciones osteoarticulares de las treponematosis." EMC - Aparato Locomotor 53, no. 3 (August 2020): 1–9. http://dx.doi.org/10.1016/s1286-935x(20)44109-7.

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