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Relevant bibliographies by topics / Trial-wise models

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Academic literature on the topic 'Trial-wise models'

Author: Grafiati

Published: 20 February 2023

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Journal articles on the topic "Trial-wise models"

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Audisio, Katia, Hillary Lia, Newell Bryce Robinson, et al. "Impact of the COVID-19 Pandemic on Non-COVID-19 Clinical Trials." Journal of Cardiovascular Development and Disease 9, no. 1 (2022): 19. http://dx.doi.org/10.3390/jcdd9010019.

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Randomized controlled trials (RCT) were impacted by the COVID-19 pandemic, but no systematic analysis has evaluated the overall impact of COVID-19 on non-COVID-19-related RCTs. The ClinicalTrials.gov database was queried in February 2020. Eligible studies included all randomized trials with a start date after 1 January 2010 and were active during the period from 1 January 2015 to 31 December 2020. The effect of the pandemic period on non-COVID-19 trials was determined by piece-wise regression models using 11 March 2020 as the start of the pandemic and by time series analysis (models fitted usi

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Franco, Pamela, Irene Huebschle, Carl Philipp Simon-Gabriel, et al. "Mapping of Metabolic Heterogeneity of Glioma Using MR-Spectroscopy." Cancers 13, no. 10 (2021): 2417. http://dx.doi.org/10.3390/cancers13102417.

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Proton magnetic resonance spectroscopy (1H-MRS) delivers information about the non-invasive metabolic landscape of brain pathologies. 1H-MRS is used in clinical setting in addition to MRI for diagnostic, prognostic and treatment response assessments, but the use of this radiological tool is not entirely widespread. The importance of developing automated analysis tools for 1H-MRS lies in the possibility of a straightforward application and simplified interpretation of metabolic and genetic data that allow for incorporation into the daily practice of a broad audience. Here, we report a prospecti

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Kidger, Judi, Nicholas Turner, William Hollingworth, et al. "An intervention to improve teacher well-being support and training to support students in UK high schools (the WISE study): A cluster randomised controlled trial." PLOS Medicine 18, no. 11 (2021): e1003847. http://dx.doi.org/10.1371/journal.pmed.1003847.

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Background Teachers are at heightened risk of poor mental health and well-being, which is likely to impact on the support they provide to students, and student outcomes. We conducted a cluster randomised controlled trial, to test whether an intervention to improve mental health support and training for high school teachers led to improved mental health and well-being for teachers and students, compared to usual practice. We also conducted a cost evaluation of the intervention. Methods and findings The intervention comprised (i) Mental Health First Aid training for teachers to support students;

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Han, Manman. "The Dose-Response Relationship between Alcohol Consumption and the Risk of Type 2 Diabetes among Asian Men: A Systematic Review and Meta-Analysis of Prospective Cohort Studies." Journal of Diabetes Research 2020 (August 24, 2020): 1–8. http://dx.doi.org/10.1155/2020/1032049.

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The objective of this review was to provide a summary of the literature on the dose-response relationship between alcohol consumption and risk of type 2 diabetes (T2D) in Asian populations, particularly men. The present study was recorded in PROSPERO as CRD 42019121073. We searched the PubMed-Medline, Web of Science, and Cochrane Library for studies published in any language since the database inception to January 2019. Prospective cohort studies were included in the meta-analysis. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated for random-effects models and dose-respon

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Wang, Shuai, Yu Di, Rongyu Li, et al. "Abstract 3102: MiniPDX and omics analysis for clinical indication and biomarker identification." Cancer Research 82, no. 12_Supplement (2022): 3102. http://dx.doi.org/10.1158/1538-7445.am2022-3102.

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Abstract MiniPDX as an in vivo version of the organoid assay represents a novel platform of fast turnaround (7 days) in vivo drug sensitivity test, using either fresh patient tumor samples or tissues from established PDX models. We systematically evaluated and compared the response rates of MiniPDX assays and PDX assays pair-wise in 26 PDX models involving 3 types of cancers to 12 clinical relevant regimens, and found a high correlation between drug responses between the two assays, with sensitivity and specificity of 80% and 93%, respectively. LIDE has completed over 2,400 MiniPDX assays for

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Forouzannezhad, Parisa, Dominic Maes, Daniel S. Hippe, et al. "Multitask Learning Radiomics on Longitudinal Imaging to Predict Survival Outcomes following Risk-Adaptive Chemoradiation for Non-Small Cell Lung Cancer." Cancers 14, no. 5 (2022): 1228. http://dx.doi.org/10.3390/cancers14051228.

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Medical imaging provides quantitative and spatial information to evaluate treatment response in the management of patients with non-small cell lung cancer (NSCLC). High throughput extraction of radiomic features on these images can potentially phenotype tumors non-invasively and support risk stratification based on survival outcome prediction. The prognostic value of radiomics from different imaging modalities and time points prior to and during chemoradiation therapy of NSCLC, relative to conventional imaging biomarker or delta radiomics models, remains uncharacterized. We investigated the ut

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Chapman, Judy-Anne W., Lois E. Shepherd, James N. Ingle, et al. "Competing risks of death in NCIC CTG MA.27 adjuvant exemestane versus anastrozole." Journal of Clinical Oncology 31, no. 15_suppl (2013): 564. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.564.

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564 Background: Our group previously examined if baseline patient/tumor characteristics, or prior treatment affected cause of death in MA.17, a placebo controlled extended adjuvant trial of the aromatase inhibitor (AI) letrozole. We now examine factor effects on all cause mortality in MA.27. Methods: MA.27 was an adjuvant phase III superiority trial of 5 yrs of exemestane vs anastrozole, in ER+ postmenopausal breast cancer accrued between 2003 and 2008; event free survival was similar. We examined by intention-to-treat, the multivariate time-to-breast cancer-specific (BrCa), cardiovascular (Ca

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Suteja, Suteja, Saifuddin Saifuddin, Farihin Farihin, Aris Aris, and Widodo Winarso. "A Traditional Game-Based Parenting Model as a Cultural-Inheritance Medium in Early Childhood Education." International Journal of Learning, Teaching and Educational Research 21, no. 3 (2022): 143–65. http://dx.doi.org/10.26803/ijlter.21.3.9.

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Education related to parenting must be provided for parents to have a broad perspective in preparing a child's education. The use of traditional games in parenting can be developed to apply and preserve the local values and norms in the next generation from an early age. Based on traditional games, a parenting model is also an effort to transmit good and wise local culture to pre-school children. This research offers a parenting model based on the traditional games relevant to pre-school child education (PAUD – Pendidikan Anak Usia Dini). This type of research comprises Research and Developmen

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Graf, Alexandra Christine, Dominic Magirr, Alex Dmitrienko, and Martin Posch. "Optimized multiple testing procedures for nested sub-populations based on a continuous biomarker." Statistical Methods in Medical Research 29, no. 10 (2020): 2945–57. http://dx.doi.org/10.1177/0962280220913071.

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An important step in the development of targeted therapies is the identification and confirmation of sub-populations where the treatment has a positive treatment effect compared to a control. These sub-populations are often based on continuous biomarkers, measured at baseline. For example, patients can be classified into biomarker low and biomarker high subgroups, which are defined via a threshold on the continuous biomarker. However, if insufficient information on the biomarker is available, the a priori choice of the threshold can be challenging and it has been proposed to consider several t

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Spreng, R. Nathan, Kathy D. Gerlach, Gary R. Turner, and Daniel L. Schacter. "Autobiographical Planning and the Brain: Activation and Its Modulation by Qualitative Features." Journal of Cognitive Neuroscience 27, no. 11 (2015): 2147–57. http://dx.doi.org/10.1162/jocn_a_00846.

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To engage in purposeful behavior, it is important to make plans, which organize subsequent actions. Most studies of planning involve “look-ahead” puzzle tasks that are unrelated to personal goals. We developed a task to assess autobiographical planning, which involves the formulation of personal plans in response to real-world goals, and examined autobiographical planning in 63 adults during fMRI scanning. Autobiographical planning was found to engage the default network, including medial-temporal lobe and midline structures, and executive control regions in lateral pFC and parietal cortex and

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Dissertations / Theses on the topic "Trial-wise models"

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Chan, Chung Kiu Jonas. "Mechanisms of the Partial Reinforcement Extinction Effect." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20925.

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The partial reinforcement extinction effect (PREE) is a well-known phenomenon in associative learning. It refers to the paradoxical observation that after an animal has been trained on a partial reinforcement (PRf) schedule, it exhibits greater responding in the face of extinction than an animal that was trained on a continuous reinforcement (CRf) schedule, even if it has received fewer pairings of the conditioned stimulus (CS) and the unconditioned stimulus (US). The current thesis investigated the mechanisms that produce the PREE. We showed that the PREE is eliminated when partially reinforc

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Conference papers on the topic "Trial-wise models"

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Buryachenko, Valeriy A. "General Integral Equations and Bounds of the Effective Moduli of Random Structure Composites." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70777.

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One considers a linear elastic random structure composite material (CM) with a homogeneous matrix. The idea of the effective field hypothesis (EFH, H1) dates back to Faraday, Poisson, Mossotti, Clausius, and Maxwell (1830–1870, see for references and details [1], [2]) who pioneered the introduction of the effective field concept as a local homogeneous field acting on the inclusions and differing from the applied macroscopic one. It is proved that a concept of the EFH (even if this term is not mentioned) is a (first) background of all four groups of analytical methods in physics and mechanics o

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Arena, Andrea, Walter Lacarbonara, and Pier Marzocca. "Unsteady Aerodynamic Modeling and Flutter Analysis of Long-Span Suspension Bridges." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70289.

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A parametric one-dimensional model of suspension bridges is employed to investigate their static and dynamic aeroelastic behavior in response to a gust load and at the onset of flutter. The equilibrium equations are obtained via a direct total Lagrangian formulation where the kinematics for the deck, assumed to be linear, feature the vertical and the chord-wise displacements of the deck mean axis and the torsional rotations of the deck cross sections, while preserving their shape during rotation. The cables elasto-geometric stiffness contribution is obtained by condensing the equilibrium in th

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Reports on the topic "Trial-wise models"

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McPhedran, R., K. Patel, B. Toombs, et al. Food allergen communication in businesses feasibility trial. Food Standards Agency, 2021. http://dx.doi.org/10.46756/sci.fsa.tpf160.

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Background: Clear allergen communication in food business operators (FBOs) has been shown to have a positive impact on customers’ perceptions of businesses (Barnett et al., 2013). However, the precise size and nature of this effect is not known: there is a paucity of quantitative evidence in this area, particularly in the form of randomised controlled trials (RCTs). The Food Standards Agency (FSA), in collaboration with Kantar’s Behavioural Practice, conducted a feasibility trial to investigate whether a randomised cluster trial – involving the proactive communication of allergen information a

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