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1
Horner, Katherine A. "Synthesis and applications of triazole- and triazine-containing amino acids." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/11024/.
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Through their use as mimics of post-translational modifications (PTMs) and in bioorthogonal chemical reporting strategies, unnatural amino acids (UAAs) are vital tools for studying biological systems. τ-Phosphotriazolylalanine I can act as a non-hydrolysable analogue of phosphohistidine and is compatible with the Fmoc-strategy for peptide synthesis. Peptides containing either I or an alternative phosphoamino acid were synthesised and used to demonstrate the selectivity of the SH2 domain of the growth factor receptor-bound 2 protein (a phosphotyrosine binding protein) towards τ-phosphohistidine. In addition, peptides containing I were ineffectively used to study the binding interaction between a histidine-phosphorylated protein, phosphoenolpyruvate synthase and its cognate regulatory protein, YdiA. It was concluded that mimicking the primary structure of one protein through peptide generation was not sufficient to study this protein-protein interaction. As a result, third generation τ phosphotriazolylalanine II was synthesised, which has the potential to be genetically incorporated into proteins using amber suppression. Bioorthogonal reactions can be used to selectively derivatise probes onto biomolecules. Although there are a number of chemical reactions that have been used for this purpose, many are limited in terms of biocompatibility and synthetic accessibility of bioorthogonal reagents. Therefore, a novel bioorthogonal reaction was developed based on the cycloaddition of 1,2,4-triazines to strained dienophiles. An accessible and robust synthesis to novel 1,2,4-triazin-3-yl-linked amino acid III was devised and its reactivity towards a range of strained dienophiles was investigated. It was determined that III reacted readily with bicyclononyne at 37 °C with a second order rate constant between 0.3 - 0.5 ×10-3 M-1 s-1, depending on solvent mix. The utility of III towards late stage functionalisation of probe molecules was also demonstrated through generation of a fluorescent probe containing III. This triazine probe was used to demonstrate cycloaddition of triazine to a strained dienophile in vitro.
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Hug, Stephan. "Covalent triazine frameworks." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-185677.
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Kalenga, J. D. "Studies in 1,2,3-triazine chemistry." Thesis, University of East Anglia, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356612.
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ALFIO, Alessia. "Sintesi ed Attività Biologica di nuovi derivati Triazenici e Triazinici." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91003.
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Moreno, Karlos Xavier. "NMR studies of the conformation of a triazine dendrimer and the synthesis of a platinated triazine dendrimer." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2450.
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Tambo, Yasukazu. "Validierung eines Enzymimmunoassays und Entwicklung von Standardmaterialien für die Analytik freier und gebundener Triazinrückstände." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966389441.
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Carling, Caroline J. "Transition metal chemistry of triazine based ligands." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435449.
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Mason, Pamela V. "Triazine hosts for metal coordination and hydrogen-bonding." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415866.
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Pearson, J. C. "Affinity precipitation of protein using triazine dye derivatives." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378382.
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Cole, Kyle S. "Synthesis and Characterization of Triazine-Based Chemical Probes." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:107697.
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Thesis advisor: Eranthie WeerapanaThe 1,3,5-triazine is a privileged scaffold in that it is planar and has three-fold symmetry which allows for controlled modification around the ring structure with various substituents. In this thesis, we report on two modular inhibitor libraries that center around a 1,3,5-triazine core scaffolding system, which have been shown to target protein disulfide isomerase A1 (PDIA1), glutaredoxin-3 (GLRX3), and 6-phosphofructo-1-kinase (PFKP). Protein disulfide isomerase A1 (PDIA1) is a thiol-disulfide oxidoreductase localized in the lumen of the endoplasmic reticulum (ER), and is an important folding catalyst and chaperone for proteins in the secretory pathway. PDIA1 contains two active-site domains (a and a’), each containing a Cys-Gly-His-Cys (CGHC) active-site motif. Here, we synthesize a targeted library o second-generation triazine-based inhibitors to optimize the potency and selectivity of our lead compound, RB-11-ca. Characterization of this targeted library afforded an optimized PDIA1 inhibitor, KSC-34, which covalently modifies C53 in the a site of PDIA1 and demonstrates time-dependent inhibition of the reductase activity of PDIA1 in vitro with a kinact/KI = 9.66 x 103 M-1s-1. Interestingly, KSC-34 treatment demonstrated that a-site inhibition led to decreased secretion of amyloidogenic antibody light chain, thus illustrating that site-selective inhibitors like KSC-34 provide useful tools for delineating the pathological role and therapeutic potential of PDIA1. In 2014, our lab first reported on RB7, a dichlorotriazine-based electrophilic small molecule which displayed extremely high reactivity and selectivity toward lysine residues in the proteome. Herein, we further on this study by investigating the unique reactivity of RB7 through the synthesis of a second-generation small molecule electrophile library and investigating proteome-wide reactivity in vitro and in situ. This library afforded KSC-46, an RB-7 analogue with p-chlorothiophenol tuning element, which provided optimal proteome reactivity to use as a scaffold for the generation of a targeted library. To take advantage of the tuned reactivity of KSC-46, a second-generation targeted library was generated to target react residues in the proteome. This library yielded two molecules, KSC-56 and KSC-65, which were identified to target glutaredoxin-3 (GLRX3) and 6-phosphofructo-1-kinase (PFKP), respectively. GLRX3 is a cytosolic, monothiol iron-sulfur cluster chaperon protein which relies on two nucleophilic cysteine residues to bind and transfer iron clusters. PFKP is known to catalyze the first irreversible step in glycolysis and regulates the flux of glucose metabolism in the cell, which makes PFKP an attract therapeutic target. KSC-56 was further characterized to bind to Cys261 in the C-terminal glutaredoxin domain of GLRX3
Thesis (PhD) — Boston College, 2018
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
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Glowacki, Aurore. "Synthèse de nouveaux dérivés d’hydrazine pour la propulsion spatiale." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1187.
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Ce travail est dédié à la synthèse de composés polyazotés linéaires (N-N)2 et cycliques (N N)3, composés peu étudiés, pour des applications dans le domaine de la propulsion spatiale. La forte toxicité des hydrazines, utilisées actuellement dans les systèmes à biergols stockables et menacées par la réglementation REACH, impose aux industriels de les remplacer par de nouveaux ergols verts, aussi voire plus performants au niveau de la propulsion, mais surtout ne présentant aucun impact significatif sur la santé humaine et l’environnement. À ce jour, aucun candidat n’a été identifié pour remplacer les hydrazines spatiales. Cependant un candidat a été proposé par le CNES en raison de ses performances théoriques, il s'agit de ***. L’objectif principal de cette thèse est de converger le plus possible vers la synthèse de cette cible. Il s’agit également d’étudier la stabilité des composés polyazotés synthétisés et d’étendre la compréhension de la chimie de l’azote. Les différentes voies de synthèse des précurseurs, les triazanes et les azimines, sont présentées ainsi que leur réactivité notamment l’oxydation des triazanes et la photochimie des aziminesAnglais This work is dedicated to the synthesis of linear (N-N)2 and cyclic (N N)3 polynitrogen compounds, not well studied, for applications in the field of space propulsion. The high toxicity of hydrazines, currently used in storable bipropellant systems and threatened by the REACH regulation, imposes industrial businesses to replace them by new green propellants, with high or better propulsion performances, but also with low impact towards human health and the environment.To this day, no candidate has been identified to replace space-use hydrazines. However, one candidate has been proposed by the French Space Agency CNES, due to the theorical performances, namely ***. The main objective of this thesis is to converge as much as possible to the synthesis of this target molecule. The aim is to study the stability of the polynitrogen compounds synthesized and to extend the understanding of the nitrogen chemistry. The different pathways for the synthesis of precursors, the triazanes and the azimines, are developed as well as their reactivity especially the oxidation of triazanes and the photochemistry of azimines
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Behl, Marc. "Synthese und Strukturierung von polymeren Halbleitern Triphenylamine und Triazine /." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97189518X.
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Blyden, E. R. "Molecular genetics of triazine resistance in Senecio vulgaris L." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383076.
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Hasson, Mohammed. "Triazine based N-Heterocyclic carbenes : synthesis, coordination and catalysis." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/78611/.
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This thesis describes the synthesis and characterization (1H, 13C NMR, CHN, and X-ray) of new NHC ligands incorporating a triazine core and their complexation with Ag(I), Pd(II) and Ru(II) metals. Imidazolium salts [2.4H]I – [2.7H]Br and [2.10H] - [2.15H]Br were obtained by reaction of 2,4-diamino-6-chloro-1,3,5-triazine (diamino = morpholine, piperidine, diethylamine, or dimethylamine) with H- imidazole followed by alkylation with a variety of alkyl halides such as propyl, butyl, octyl bromides or isopropyl iodide. While the imidazolium salts [2.3H]Cl, [2.8H]Cl, [2.9H]Cl and [2.13H]Cl were prepared by reaction of N-substituent imidazole (mesityl, phenyl ethyl, and methyl) with 2,4-diamino-6-chloro-1,3,5-triazine (diamino = morpholine or dimethylamine). Silver complexes were prepared from the reaction of Ag2O with an NHC precursor salt using in situ deprotonation techniques giving the desired structures in good yield. X-ray studies with other spectral and analytical studies reveal the formation monodentate complexes of the NHC ligands. The coordination geometry at Ag is slightly distorted from the idealised linear geometry. The Ag(I)-NHC complexes were used as NHC transfer reagents to prepare Ru(ІІ) and Pd(ІІ) complexes. New monodentate Pd (ІІ) complexes were prepared by in situ deprotonation of the NHC ligand by K2CO3 in the presence of PdCl2. The catalytic activity of the complexes in the Suzuki reaction was explored with conversions of up to 100 % being observed. Bis(carbene)Pd(ІІ) complexes were prepared by transmetalation from the silver complexes with Pd(MeCN)Cl2. X-ray crystallography shows a distorted square planar geometry around the palladium metal centre for both complex types. A series of Ru (ІІ) complexes were prepared by transmetalation techniques using the silver complexes as transfer reagents with [Ru(η6-arene)Cl2]2 in dichloromethane. Single crystal studies along with other spectral and analytical studies reveal the coordination of the triazine-NHC ligand in a chelating mode where both the carbene and one of the N-donors of the triazine group ligate the metal. The complexes are active for the transfer hydrogenation of ketones with conversions up to 96%.
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Bu, Yubai. "New synthetic routes to nitrogen heterocycles : natural products and novel drug scaffolds." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/27482.
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This thesis is divided into three main sections. The first chapter contains a brief review of nitrogen heterocyclic chemistry. The second chapter reports the results and their discussion of new heterocyclic chemistry, and the experimental details are provided in the fourth chapter.
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Gooding, Stuart Robert. "Theoretical modelling of reaction mechanisms of triazine and trinitrobenzene derivatives." Thesis, University of Bath, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251114.
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Alderton, Wendy Karen. "Studies on the interaction of triazine dyes with ricin A." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282001.
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Vencill, William K. "Triazine resistance in Chenopodium album and Amaranthus hybridus in Virginia." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/94485.
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Studies were conducted to determine the distribution of s-triazine resistant biotypes of common lambsquarters (Chenopodium album L.) and smooth pigweed (Amaranthus hybridus L.) in Virginia. Collections of seed were made from suspected triazine-resistant biotypes of common lambsquarters and smooth pigweed from counties in Virginia which had reported having triazine resistance problems. Triazine resistance was confirmed by measuring chlorophyll fluorescence in the presence of atrazine. For further confirmation of triazine resistance in collected common lambsquarters and smooth pigweed biotypes, greenhouse testing of whole plants and a sinking leaf disc assay were performed. Cross-resistance to another s-triazine, as-triazine, and substituted urea herbicide was also determined for s-triazine-resistant biotypes. These studies have shown triazine- resistant smooth pigweed to be present in 19 counties and common lambsquarters to be present in 8 counties in Virginia. s-Triazine resistant biotypes were found to be resistant to another s-triazine and as-triazine herbicide, but were susceptible to the substituted urea herbicide. Additional studies were initiated to determine the effects of different temperature regimes on triazine-resistant and -susceptible biotypes of common lambsquarters and smooth pigweed from different geographical locations. These studies were conducted at the North Carolina State University Phytotron facility in controlled environment growth chambers. Triazine-resistant common lambsquarters biotypes from Virginia, Maryland, and Switzerland as well as a smooth pigweed biotype from Virginia were examined. Triazine-susceptible biotypes of common lambsquarters and smooth pigweed were included as controls. Shoot height, weight, chlorophyll a and b content, and whole leaf fatty acid content of common lambsquarters and smooth pigweed were determined at 18°/14° C, 26°/22° C, and 36°/26° C. Measurements of shoot height were made at 30 and 63 days after planting. The shoot weight, chlorophyll a and b content, and fatty acid content was determined from plants harvested at 63 days after planting. These data indicate common lambsquarters biotypes from different geographical regions exhibited a differential response to temperature. There was no difference between triazine-resistant and -susceptible biotypes in response to temperature. Differences were detected between triazine-resistant smooth pigweed biotypes which indicated that the susceptible biotypes were more vigorous as indicated by shoot height and weight at lower temperatures than triazine-resistant biotypes of smooth pigweed.M.S.
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Jammal, Ali el. "Etude électrochimique d'une triazine substituée et de quelques complexes métalliques." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb375984781.
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Augier, de Cremiers Hugues. "Methods of controlling supramolecular structures in solution." Thesis, Heriot-Watt University, 2002. http://hdl.handle.net/10399/450.
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Миронович, Людмила Максимівна, Людмила Максимовна Миронович, Liudmyla Maksymivna Myronovych, and С. М. Єфіменко. "Синтез та реакційна здатність похідних 1,2,4-триазину." Thesis, Вид-во СумДУ, 2010. http://essuir.sumdu.edu.ua/handle/123456789/5297.
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PEREZ, YAFA. "Toxicologie et ecotoxicologie des triazines utilisees comme herbicides et particulierement des chlorotriazines." Strasbourg 1, 1987. http://www.theses.fr/1987STR10719.
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Zamarion, Vitor de Moraes. "Estudos e aplicações de ressonância plasmônica superficial em nanosondas SERS." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/46/46134/tde-28032008-092022/.
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Através da modificação adequada da superfície de nanopartículas de ouro com uma molécula sulfurada que apresenta vários sítios de coordenação, foi possível desenvolver um conceito interessante de sensoriamento quantitativo conjugado ao efeito SERS. Estudos com sistemas desse tipo permitem explicar não apenas como uma molécula se liga a uma superfície, mas também como aproveitar essas informações para elaborar sensores de alta sensibilidade. Entretanto, as teorias eletrodinâmico-quânticas que regem as interações dos plasmons de superfície ainda estão sendo trabalhadas. Dessa forma, o presente trabalho procura explorar as teorias atuais sobre a origem dos plasmons e as interações plasmônicas entre as partículas. Essas interações promovem fenômenos de intensificação do espalhamento Raman por superfície e também foram discutidas. Visando conhecer e compreender os fenômenos envolvidos, foram sintetizadas nanopartículas de ouro estabilizadas com 2,4,6-trimercapto-1,3,5-triazina e estudada a química do ligante na superfície das nanopartículas de ouro. Além disso, foi estudada a influência dos equilíbrios ácido-base nos espectros SERS e monitorou-se as bandas mais diretamente sensíveis ao pH, associando as mudanças observadas aos diversos equilíbrios das espécies presentes em solução. Por fim, explorou-se o conceito de sensoriamento através das mudanças nos modos vibracionais dos espectros SERS, na formação de complexos em superfície.Surface modification of gold nanoparticles with a molecule exhibiting several coordination points, allowed to elaborate an interesting concept for quantitative sensing conjugated with the SERS effect. In such systems it is important to know how the molecule binds to the surface, since, based on those informations one can elaborate sensors displaying high sensibility.. However, in dealing with the interaction of nanoparticles with light, the electrodynamic-quantum theories related to the interactions of the surface plasmons are not yet completely developed. In this way, in this t dissertation we made use of the current theories to understand the origin of the plasmons and of how they interact with the the nanoparticles. We have synthesized gold nanoparticles stabilized with 2,4,6-trimercapto-1,3,5-triazine and studied the ligand chemistry at the particles surface.. The influence of acid-base equilibria was studied based on the changes of the SERS spectra SERS with the pH, and interpreted in terms of the several equilibria of the species in solution. Finally, a new sensing concept, based on the observed changes in the SERS spectra in the presence of metal ions, was successfully demonstrated.
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Malotaux, Christophe. "Les Triazines-atrazine entre autres, présences dans l'environnement et dans l'eau." Paris 5, 1992. http://www.theses.fr/1992PA05P242.
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ISSARTEL, VERONIQUE. "Structures hétérocycliques à azote tête de pont visant le système immunitaire et/ou le système nerveux central." Clermont-Ferrand 1, 1997. http://www.theses.fr/1997CLF1PP01.
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Mackenzie, Linda. "Investigations of new synthetic approaches to imidazo[4,5-e]-1,2,4-triazine (6-azapurine) and pyrimido[4,5-e]-1,2,4-triazine (6-azapteridine) derivatives and related polyaza heterocycles." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/12518.
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This thesis is concerned with the development of new, general, synthetic approaches to aza- and deaza-aza- pteridines and purines of potential biological interest. The construction of derivatives of four such ring systems, all containing a 1,2,4-triazine nucleus was studied. In the case of 6-aza-1-deaza-pterine synthesis, annulation of the appropriate bicyclic 1,2,3-triazolo-[1,-PROB*LEM]-1,2,4-triazine derivatives afforded the corresponding 1,2,3-triazolo[1,5-PROB*LEM]-pyrido[4,3-PROB*LEM]-1,2,4-triazines. The latter underwent smooth acid-catalysed triazole scission providing a general route to variously functionalised pyrido[4,3-PROB*LEM]-1,2,4-triazine (6-aza-1-deazapteridine) derivatives. Syntheses of the two classes of aza- and aza-deaza-purines investigated were based on a common type of 1,2,3-triazolo[1,5-PROB*LEM]-1,2,,4-triazine intermediate, bearing a readily displaceable benzenesulphonyl moiety ortho to an amino- group in the triazine ring. The construction of 6-azapurines was approached by nucleophilic displacement of the benzenesulphonyl group with cyanamide anion with concomitant cyclisation of the resulting ortho-amino cyanamide products giving the corresponding tricyclic 1,2,3-triazolo[1,5-PROB*LEM] imidazo[4,5-PROB*LEM]-1,2,4-triazine derivatives. However, attempts to obtain molecules of the latter type appropriate for acid-catalysed triazole scission to imidazo[[4,5-PROB*LEM]-1,2,4-triazines (6-azapurines) were unsuccessful. Synthesis of 6-aza-7-deaza-purines used a similar approach to that investigated for 6-azapurines, namely nucelophilic displacement of the benzenesulphonyl group in ortho-benzenesulphonyl 1,2,3-triazolo[1,5-PROB*LEM]-1,2,4-triazine derivatives but using stabilised carbanions rather than amide ions. Acid-catalysed triazole scission of the resulting tricyclic 1,2,3,-triazolo[1,,5-PROB*LEM]-pyrrolo[2,3-PROB*LEM]-1,2,4-trizine derivatives then afforded a new and potentially general route to pyrrolo[2,3-PROB*LEM]-1,2,4-triazine (6-aza-7-deazapurine) derivatives.
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Dupont, Stephane. "Bound (nonextractable) residues of triazine herbicides in soybean and canola plants." Thesis, University of Ottawa (Canada), 1989. http://hdl.handle.net/10393/21091.
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Oketunde, Olukayode Felix. "The adsorptive behaviour of two triazine herbicides in three Nigerian soils." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22372.pdf.
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Stewart, David Johnston. "Immobilisation of triazine dyes on inert hydrophobic supports for affinity chromatography." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315974.
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Olson, B. M. "Spectroscopic study of interactions between s-triazine herbicides and humic substances." Thesis, University of Aberdeen, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374630.
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Liebl, Mario R. [Verfasser], and Jürgen [Akademischer Betreuer] Senker. "Functional Triazine-Based Porous Organic Networks / Mario Liebl ; Betreuer: Jürgen Senker." Bayreuth : Universität Bayreuth, 2018. http://d-nb.info/1199451339/34.
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Romson, Tomas. "Triazine-based adhesive : An adherence study on clinically used metal surfaces." Thesis, KTH, Ytbehandlingsteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278862.
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When a material is adhered onto a specific surface it is relevant to know how to make thematerial stay on the surface. By investigating different primers to use with a triazine-basedadhesive, further improvements to using the adhesive on metals can be achieved. This studyfound that an adhesive of (2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(ethane-2,1-diyl)tris(3-mercaptopropanoate) (TEMPIC) and 1,3,5-triallyl-1,3,5-triazinane-2,4,6-trione(TATATO) adhered to titanium and stainless steel, two clinically used metal surfaces. Itfurther found that between a phosphonic acid primer, a biomimetic catechol primer and acommercially available silane primer the phosphonic acid primer gave the best adhesion.These results could be because of a higher amount of crosslinking for the phosphonic acidprimer. For further testing increased pH and increased amount as well as increasedhydrolysation time for the catechol and silane primers respectively is suggested. Shearstrength testing was used to determine the adhesion strength. The shear strength testswere done with conditioning in phosphate buffer saline (PBS) solution for 24h beforehand
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Wiles, M. C. "The behaviour of affinity dyes at the interface of immiscible electrolytes." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382976.
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Drummond, Allison M. "New synthetic and structural alkali metal chemistry of alkoxide and triazine ligands." Thesis, University of Strathclyde, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425956.
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Macdonald, Philip Alan Carleton University Dissertation Biology. "Studies on the photosynthetic properties of s-triazine sensitive and resistant weeds." Ottawa, 1985.
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Smadhi, Meriem. "Nouveaux glycoclusters polysulfurés à coeur triazine : synthèse et interaction envers PA-IL." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10123.
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Les interactions protéines-carbohydrates sont à la base de nombreux processus biologiques physiologiques aussi bien que pathologiques. Ces interactions incluent la synthèse et la dégradation enzymatique des oligosaccharides, la cohésion des tissus, l'immunité, le cancer ou encore l'infection bactérienne et virale. L'inhibition de ce type d'interaction par des molécules multivalentes synthétiques telles les glycopolymères, glycodendrimères, glycoclusters, etc. fait l'objet d'études importantes depuis plusieurs décennies. L'obtention de telles molécules pourrait permettre de développer de nouvelles thérapies qui pourraient palier notamment la multi-résistance aux antibiotiques. De plus, la détection de telles interactions par des méthodes simples et faciles à mettre en oeuvre permettrait une amélioration de la compréhension de ces phénomènes, ainsi que le diagnostic rapide de la présence de microorganismes. C'est dans ce contexte, que nous avons développé une nouvelle classe de composés glycosylés multivalents à coeur triazine. Ces glycoclusters de basse valence, ont la particularité de présenter une double fonctionnalité : l'inhibition d'interactions lectine-sucre par des effets de multivalence ainsi que la détection de ces interactions. Nous présentons dans ce manuscrit, la synthèse d'une nouvelle famille de glycoclusters polysulfurés à coeur triazine portant des épitopes saccharidiques tels que D-glucose, D-galactose, D-mannose, L-fucose, ainsi que leurs évaluations biologiques réalisées sur des lectines de Pseudomonas aeuriginosa. Nous avons ainsi mis en évidence la possibilité de reconnaître et de détecter les interactions lectine-sucre dans un premier temps par association d'un cluster mixte portant un fluorophore, et de façon plus sophistiquée, grâce à un système à géométrie variable incorporant dans le scaffold même un switch photochimique variant l'arrangement des sucres dans l'espaceProtein-carbohydrate interactions mediate a wide range of biochemical processes. Amongst these is the process of bacterial infection, which often proceeds through carbohydrate-binding lectins involved in biofilm formation. Even if the individual associations result from weak interactions, the assembly of multiple carbohydrate-protein interactions, typically more than additive, confers to the system the required specificity and avidity for their biological functions. In order to study this « glycocluster effects », a number of scaffold systems presenting multivalent carbohydrate ligands have been prepared in the literature. Dendrimers, polymers, peptides, calixarenes, to name a few, have been used as core molecules for the synthesis of multivalent glycoconjugates. The purpose of this work is to design new glycoclusters which exhibit dual functionality: the inhibition of carbohydrate-protein interactions via a multivalency effect; and detection of the interactions via fluorescence spectroscopy. A first generation of polysulfurated glycoclusters, organized around a heteroaromatic core, was synthesized using click chemistry reactions, which provided a family of highly soluble and readily accessible clusters. The glycoclusters were evaluated for their ligand-lectin interactions, multivalency effects, thermodynamic parameters, and abilty to modulate biofilm formation by Pseudomonas aeruginosa, a major causative agent of lung infections in cystic fibrosis patients. We describe a new family of ‘switchable glycoclusters’ based on photochromic behavior. They are designed to generate a modulated fluorescence signal as well as a defined change in the three-dimensional arrangement of the sugar epitopes, and may eventually provide significantly improved probes for studying the distribution, dynamics, interactions, and activities of specific lectins
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Le, Falher Laetitia. "Préparation et dérivatisation de 4H-pyrido[e][1,3]oxazinones : une contribution à la diversité chimique." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066344.
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Ce manuscrit porte sur la synthèse et les applications d'une nouvelle série de composés hétéroaromatiques : les 4H-pyrido[e][1,3]oxazin-4-ones. La première partie de ce manuscrit présente la préparation de ces squelettes via une réaction d'O-arylation intramoléculaire. La seconde partie du manuscrit repose sur la réactivité de ces entités chimiques et de leur utilisation en tant qu'intermédiaires de synthèse. La fonctionnalisation des 4H-pyrido[e][1,3]oxazin-4-ones, via des réactions de couplage pallado-catalysées, a permis d'obtenir des systèmes polyfonctionnalisés plus complexes. Les pyrido-oxazinones ont également été transformées, en une étape, en divers petits hétérocycles d'intérêt : les 1,3,5-triazines, les 1,2,4-triazoles et les 1,2,4-oxadiazoles. La dernière partie du manuscrit est consacrée à l'utilisation des molécules synthétisées comme potentielles sondes fluorescentes pour la détection de protéines oxydéesThis work focused on the synthesis and applications of a novel series of heteroaromaticcompounds: the 4H-pyrido[e][1,3]oxazin-4-ones. The first part of this thesis presents thepreparation of these pyrido-oxazinones via an intramolecular O-arylation reaction. The secondpart of this work relies on the reactivity of these chemical entities and their use as buildingblocks. The functionalization of the 4H-pyrido[e][1,3]oxazin-4-ones has been studied viacross-coupling reactions to obtain more elaborated structures. The pyrido-oxazinones werealso converted, in one step, into other diverse small molecules of interest: 1,3,5-triazines,1,2,4-triazoles and 1,2,4-oxadiazoles. The last part of this thesis was devoted to the use of theobtained heterocycles as potential fluorescent probes for the detection of carbonylatedproteins
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Vieira, Viviane Cristina [UNESP]. "Caracterização molecular de acessos de capim-colchão (Digitaria nuda) e resposta à ametrina." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/102825.
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As plantas daninhas da família Poaceae são as principais plantas que infestam a cultura de cana-de-açúcar. As espécies de gramíneas conhecidas por capim-colchão, estão entre as de maior ocorrência nas lavouras de cana-de-açúcar no Brasil. Atualmente o uso do controle químico está sendo o mais empregado para controle de Digitaria, porém há alguns relatos de falha no controle, principalmente com referência a herbicidas pertencentes ao grupo das triazinas, que bloqueiam a cadeia fotossintética, no fotossistema. As técnicas moleculares estão sendo bem recomendadas para análise da diversidade genética em plantas daninhas. Para a caracterização molecular vinte iniciadores foram utilizados para o RAPO e, para o PCR¬RFLP utilizou-se de dois iniciadores específicos P1 e P2 e a enzima de restrição Mael. O seqüenciamento foi realizado com o amplicom produzido com os iniciadores P1 e P2. Para o tratamento químico utilizou-se a ametrina. Com isso, esse trabalho teve como objetivos: caracterizar dez acessos de Digitaria spp. por marcadores RAPO e PCR¬RFLP, sequenciar uma região conservada do gene psbA e verificar possíveis associações entre o polimorfismo desse gene e a resposta fenotípica à ametrina. Pela análise molecular não houve variabilidade genética entre os acessos e todos apresentaram a mesma resposta fenotípica ao herbicida utilizado. Com esses resultados, concluiu-se que o capim-colchão dos dez acessos estudados pertence à espécie Digitaria nuda e não foi observada relação entre a ocorrência de polimorfismo e a suscetibilidade à ametrina, provavelmente porque todos os acessos estudados foram controlados na dose recomendada do herbicida.
The weed of family Peaceae are the most important infesting sugarcane crop plants. The gramineous species known as crabgrass are among the ones with high occurrence in Brazil sugarcane crop. Presently the use of chemical control is being the most common way used for the control of Digitaria, but with few controlling occurrences fails, with emphasis for those herbicides belonging to triazine group which block the photosynthetic chain at the photosystem II leveI. Molecular techniques are being recommended for the analysis of the genetic diversity such weed. For the molecular characterization twenty primers were used for RAPO and for the PCR¬RFLP a set of two specific primers P1 and P2 were used together with restriction enzyme Mael. The ONA sequencing was performed with an amplicon sample produced with the primers P1 and P2. For the chemical treatment control ametryn was selected. Thus this work had objectives as follows: to characterize ten accessions of Digitaria spp. by RAPO and PCR-RFLP markers, and to sequence a conserved region of the psbA gene so as to investigate the possible polymorphic associations of this gene in response to the phenotypic response to ametryn. For the molecular analysis it did not have genetic variability among the accessions and all had presented the same phenotypic response to the used herbicide. Based on the obtained results, it is concluded the crabgrass that ten collected accessions belong to the species Digitaria nuda, and it was not observed any relation among the polymorphism and susceptibility to ametryn probably because all the studied accessions had been controlled in the recommended dose of the herbicide.
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Dupont, Carine. "Conception, synthèse et caractérisation de molécules polyhétérocycliques azotées pour la complexation spécifique de cations métalliques." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00590462.
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La loi du 6 juin 2006 sur la gestion des déchets radioactifs de haute activité et à vie longue prévoit la recherche de solutions permettant la séparation et la transmutation des radioéléments à vie longue, pour réduire les quantités et la nocivité des déchets radioactifs ultimes. Ces déchets issus du retraitement du combustible nucléaire usé sont actuellement vitrifiés à La Hague. Ainsi, le projet " séparation poussée " vise à compléter le procédé industriel PUREX par le développement de procédés permettant d'extraire les actinides mineurs des raffinats PUREX où se trouvent également des produits de fission constitués principalement de lanthanides, neutrophages. Pour réaliser la séparation poussée, les actinides mineurs des raffinats PUREX doivent être séparés par des molécules spécifiques. Les BTP ou bis-triazinyl-pyridines ont été largement étudiées au CEA pour la séparation actinides(III)/lanthanides(III). Elles complexent sélectivement les actinides, mais l'origine de cette sélectivité n'est pas complètement expliquée : notamment l'influence des groupements (attachés à leur structure) sur la complexation ou la sélectivité reste à démontrer. En outre, elles sont sensibles à l'hydrolyse et à la radiolyse. La première partie du travail présente la synthèse de BTP ou de BTBP, différemment substituées pour améliorer leur résistance face à l'hydrolyse ou à la radiolyse, et une nouvelle famille de ligands polyaromatiques azotés : les BPBT, présentant un enchaînement original de cycles pyridine et triazine, différent de toutes les structures décrites jusqu'à présent dans la littérature. La seconde partie de ce travail est consacrée à l'étude physico-chimique de nouvelles molécules obtenues, en déterminant leurs constantes de protonation et de complexation, pour connaître l'influence des différents groupements sur la complexation et la sélectivité. Enfin, le troisième volet concerne l'étude des propriétés de ces ligands en extraction liquide-liquide, utilisés soit comme extractants lipophiles, soit comme complexants hydrophiles.
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Zhang, Qian Amy. "Ecotoxicities and ecological risks of irgarol 1051 and its related s-triazine compounds in tropical marine ecosystems." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41757956.
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Mehta, Manish. "Electrochemical degradation of 2,4,6-trinitrotoluene; 2,4 -dinitrotoluene and hexahydro-1,3,5-trinitro-1,3,5-triazine." Cincinnati, Ohio : University of Cincinnati, 1999. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1147982436.
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Boesveld, Willem Marco. "Reactions of 1,3,5-triazine with alkali metal amides and alkyls, and related chemistry." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298104.
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Liljenberg, Marcus. "Poly(triazine imide) : Growing Larger Crystallites of CrystallineCarbon Nitride and Understanding Their Dissolution." Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-377151.
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Crystalline carbon nitride has been a hot topic for the last ten years because of reports claiming it could work as a photocatalyst for cheap water splitting, a catalyst for difficult reactions inorganic chemistry and the use as a potential two-dimensional semiconductor.The carbon nitride of interest in this project is poly(triazineimide) (PTI), which has a layered structure similar to graphite. Oneof the goals was to examine the synthesis parameters to try tounderstand what makes these crystallites grow. The material was primarily analyzed using scanning electron microscopy and powder x-ray diffraction. The other goal of this project was to examine the physical properties of dissolved PTI. It is currently not understood how PTI behaves in various solvents. The effect on how the freezing point depression varies in different solvents was, therefore, tested.No strong correlations of how the morphology of the produced PTIdiffered with different synthesis parameters. Freezing point measurements suggest that a solution of PTI follows Raoult's law and can be described as a true solution.
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Alves, Favaro Marcelo. "Synthèse de nouveaux "Covalent Triazine Frameworks" pour la photoréduction du dioxyde de carbone." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSE1077.
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L'utilisation de la lumière solaire comme source d'énergie renouvelable pour promouvoir la conversion du dioxyde de carbone (CO2) est une approche intéressante pour aborder la production durable de produits chimiques et de combustibles ainsi que pour lutter contre le dérèglement climatique. Cependant, dans la plupart des systèmes photocatalytiques, l'utilisation d'un photosensibilisateur homogène représente une limitation clé pour les réactions à long terme en raison de sa faible stabilité. Par conséquent, de nouveaux matériaux photocatalyseurs et processus photocatalytiques plus efficaces et stables sont nécessaires. Ici, la stratégie de structuration au niveau moléculaire des photocatalyseurs CTF est présentée, cherchant à améliorer leur stabilité à long terme. L'intégration de centres photoactifs dans un support moléculaire défini améliore leur stabilité photocatalytique. De plus, l'incorporation de fractions chélatantes, telles que la bipyridine, offre une possibilité unique d'hétérogénéisation de complexes organométalliques, bénéficiant à la fois d'une sélectivité et d'une activité améliorées comparées au catalyseur moléculaire analogue et d'une manipulation et d'une séparation facile grâce à sa nature hétérogène. L’utlisation de macroligand, solides agissant comme le ligand dans le complexe moléculaire correspondant, est une stratégie attrayante pour combler l'écart entre la catalyse homogène et hétérogène. Dans cette thèse, la synthèse de CTF simple par condensation a été réalisée afin d'optimiser les paramètres et de mettre en évidence les principaux avantages et inconvénients de cette méthode. De plus, l'approche a été étendue à la synthèse de matériaux fonctionnalisés, basés sur des ligands bipyridiniques. En utilisant la stratégie de conception modulaire, le contenu d'un ligand dans le matériaux a été précisément contrôlé pour la première fois. De plus, en choisissant judicieusement le précurseur adapté et son contenu, il est possible de contrôler soigneusement les propriétés comme l'absorption de la lumière et la porosité, repoussant les limites du contrôle moléculaire sur la synthèse des CTF. À cet égard, les CTF basés sur la bipyridine ont été précisément conçus afin de contenir à la fois un fragment photoactif et un site de chélation pour l'hétérogénéisation des catalyseurs moléculaires au sein de la structure. Dans notre concept tout-en-un, un complexe rhodium a été hétérogénéisé au sein de macroligands CTF contenant différentes quantités de bipyridine. Ces matériaux catalysent la photoréduction du dioxyde de carbone en formiate activée par la lumière visible avec des activité de l’ordre de 4 h-1Using sunlight as a renewable source of energy to promote carbon dioxide (CO2) conversion is an interesting approach to address sustainable chemicals and fuels production as well as mitigation of climate change. However, in most photocatalytic systems, the utilization of a homogeneous photosensitizer represents a key limitation for long-term reactions due to its low stability. Therefore, novel, more efficient and stable photocatalyst materials and photocatalytic processes are required. Here, the strategy of structuration at the molecular-level of CTF photocatalysts is presented, seeking to enhance their long-term stability. The integration of photo-active centers into a molecularly defined support improve their photocatalytic stability. Moreover, the incorporation of chelating moieties, such as bipyridine, offers a unique possibility for heterogenization of organometallic complex, profiting at the same time from enhanced selectivity and activity from the molecular catalyst and easy handling and separation from its heterogeneous nature. Macroligands, a solid acting like the ligand in the corresponding molecular complex, is a pivotal strategy to bridge the gap between homogeneous and heterogeneous catalysis.In this thesis, the synthesis of simple CTFs through condensation was done in order to optimize the parameters and highlight the main advantages and drawbacks of this method. Additionally, the approach was extended to the synthesis of functionalized materials, based on bipyridine ligands. Using the strategy of modular design, the content of a ligand within the framework was precisely controlled for the first time. Additionally, by judiciously chosen the proper tailored precursor and its content, it is possible to carefully control properties like light absorption and porosity, pushing the boundaries of molecular control on the synthesis of CTFs. In this regard, CTFs based on bipyridine were precisely designed in order to contain both, a photoactive moiety and a chelating site for the heterogenization of molecular catalysts within the structure. In our all-in-one concept, a (Cp*)-Rhodium complex was heterogenized within CTFs macroligands containing different amounts of bipyridine. Those materials catalyze the carbon dioxide photoreduction to formate, driven by visible light at TOFs around 4 h-1
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Mehta, Manish. "Electrochemical Degradation of 2,4,6-Trinitrotoluene; 2,4-Dinitrotoluene and Hexahydro-1,3,5-Trinitro-1,3,5-Triazine." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147982436.
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Leung, Kevin Shurch-Yee. "Adsorption interactions of s-triazine herbicides and natural organic matter by activated carbon /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9988683.
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Pellegatti, Laurent. "Méthodologie en chimie hétérocyclique et application à la synthèse d'inhibiteurs de kinases." Thesis, Orléans, 2010. http://www.theses.fr/2010ORLE2046.
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Le cancer constitue l’une des principales causes de mortalité, et représente, de ce fait aujourd’hui un problème de santé publique majeur. Depuis quelques années, les alcaloïdes marins représentent une source d’inspiration importante pour les chimistes en vue d’obtenir de nouveaux médicaments anticancéreux. Dans cette optique, des recherches effectuées au sein de notre laboratoire ont fait état de la synthèse d’analogues de ces alcaloïdes possédant une structure tris aromatique. Nous avons développé des molécules originale analogues de ces alcaloïdes disposant d’un hétérocycle central (1,2,4-triazine et imidazo[1,2-b][1,2,4,5]tétrazine) sur lequel sont greffés deux noyaux phényles diversement substitués. L’obtention de ces composés a également été l’occasion de développer de nouvelles méthodologies de synthèse. Ainsi une nouvelle réaction de type Buchwald-Hartwig sur des méthylsulfanyl-1,2,4-triazines a pu être mise au point ainsi qu’une méthode de CH arylation palladocatalysée sur le noyau imidazo[1,2-b][1,2,4,5]tétrazine. Une partie est aussi consacrée aux réactions multicomposants de type Groebke-Blackburn. Différentes évaluations pharmacologiques ont été réalisées, notamment des tests d’inhibition sur différentes kinases et de cytotoxicité sur diverses lignées cellulaires cancéreuses humainesCancer, one of the leading causes of death, represents today a major public health problem. Over the last few years, marine alkaloids represent a source of inspiration for chemists in order to obtain new anticancer drugs. For this purpose, as a part of our laboratory researches, analogues of marine alkaloids were synthesized possessing a tris-aromatic structure. We developed originals analogs of these alacaloïds formed by a central heterocycle core (1,2,4-triazine et imidazo[1,2-b][1,2,4,5]tetrazine) on wich is graft two arylic moiety variously substituted. Obtaining these compounds was also an opportunity to develop news synthetic methodologies. So a new Buchwald-Hartwig reaction type based on methylsulfanyl-1,2,4-triazines has been perfect, as palladocatalyzed CH arylation pathway on imidazo[1,2-b][1,2,4,5]tetrazine. A part is devoted to Groebke-Blackburn multicomponant reaction. Various pharmacological analyses were carried out in particular with inhibition of various kinases and cytotoxicity evaluation on various human cancer cell lines
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Trimble, Andrew John. "Determining The Occurrence, Fate, And Effects Of Pesticide Mixtures Using The Aquatic Amphipod Hyalella Azteca." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/18.
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Previous monitoring studies by federal agencies such as the United States Geological Survey have shown that environmental contaminants rarely occur as single compounds but, rather, as mixtures. In aquatic ecosystems, mixtures of these compounds are often complex, sometimes containing dozens of compounds across a number of different chemical classes. Non-target aquatic organisms are frequently exposed to varying levels of contaminants based upon the physical properties of the chemicals, such as water solubility, and life-cycle habits of the individual organisms. In addition to this, past research has indicated that the presence of one class of contaminant may have an influence on the toxicities of other chemical classes. Water-only toxicity testing has historically provided a means by which researchers can rapidly determine the toxic effects of water-soluble compounds such as triazine herbicides and organophosphate insecticides. However, many legacy pesticides, such as organochlorine, and some current-use pesticides, such as pyrethroids, are strongly hydrophobic, and suspended or bedded sediments, rather than water, would generally be more appropriate matrices for monitoring. Yet sampling of sediments and quantification of residues of these pesticides is often lacking. Similarly, there have been few studies examining the toxicity of mixtures of these compounds in sediment. The first goal of this research was to examine the effects of select triazine herbicides on organophosphate insecticide toxicity utilizing water-only toxicity test with the aquatic amphipod Hyalella azteca. The second goal was to analyze an existing database of chemical concentrations using a toxicity-based screening approach in order to estimate the environmental hazard posed by mixtures of pyrethroid, organochlorine, and organophosphate insecticides in sediment to H. azteca. The third goal of this research was to examine the toxic effects of mixtures of different pyrethroid insecticides to H. azteca using compounds identified as most relevant from the screening phase of the study. The fourth goal of this research was to examine how pyrethroid and organochlorine insecticides partition between different size fractions within sediment and detritus, as well as between sediments with differing organic carbon content, and the resulting effects to compound toxicity and bioavailability. The final goal of this research was to examine potential modifications to bifenthrin sediment partitioning, toxicity, and bioaccessibility resulting from various dissolved salt concentrations in overlying water using H. azteca and Chironomus dilutus as reference organisms. Together, the individual objectives of this study provide a thorough and multi-tiered approach to determining the occurrence, environmental fate, biological effects, and bioavailability of frequently detected and co-occurring environmental contaminants in both agricultural and urban landscapes.
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Tissot, Marianne. "Etude de la pollution des eaux par les triazines : toxicité et méthodes de dosage." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2P041.
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Khaldi, Zineb. "Elaboration et évaluation biologique de nouveaux matériaux lignocellulosiques antibactériens." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0090/document.
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La contamination des surfaces par des bactéries et l’émergence de souches résistantes aux antimicrobiens sont des problèmes très préoccupants dans différents domaines tel que les domaines hospitalier et alimentaire. Cette contamination commence par l’adhésion de bactéries pathogènes sur une surface jusqu’à la formation de biofilms. Ces derniers contribuent à l’émergence de résistances de certaines souches bactériennes aux traitements conventionnels. Pour répondre à ces problèmes de contamination des surfaces, ces travaux de thèse portent sur le développement de nouveaux matériaux antibactériens à base de fibres de pâte à papier. Nous nous sommes intéressés, dans une première partie, à l’élaboration d’un papier antibactérien par le greffage, via un lien triazine, de deux composés d’huiles essentielles, le thymol et le carvacrol, connus pour leurs activités antibactériennes. L’évaluation microbiologique des matériaux élaborés, sur les deux souches bactériennes testées, E.coli et S.aureus, a montré un effet bactériostatique. Ces matériaux bloquent donc la croissance bactérienne empêchant ainsi la formation des biofilms. Une synergie entre le thymol et le carvacrol lorsqu’ils sont greffés sur les fibres de pâte à papier a également été montré. Dans une deuxième partie, notre étude s’est focalisée sur l’élaboration d’un papier antibactérien qui n’acquière son activité qu’après greffage et formation du motif actif « aryl-1,2,3-triazole ». Le greffage est réalisé par une réaction de « Click Chemistry », la cycloaddition de Huisguen catalysée par le cuivre I. Les tests antibactériens révèlent l’importance du substituant de l’aryle, l’influence du temps de contact et la pertinence d’utiliser des mélanges de matériaux. L’activité antibactérienne observée sur les fibres de la pâte thermomécanique est meilleure dans les deux parties. Les différents résultats obtenus sont décrits dans ce manuscritThe contamination of surfaces by bacteria and the emergence of antimicrobial resistant strains are very worrying problems in different areas such as hospital and food. This contamination begins with the adhesion of pathogenic bacteria on a surface until the formation of biofilms. These biofilms contribute to the emergence of resistances of certain bacterial strains to conventional treatments. To answer these problems of surface contamination, this thesis work focuses on the development of new antibacterial materials based on pulp fibers. In the first part, we focused on the development of an antibacterial paper by grafting, via triazine link, two essential oil compounds, thymol and carvacrol, known for their antibacterial activities. The microbiological evaluation of the developed materials against the two bacterial strains tested, E. coli and S. aureus, showed a bacteriostatic effect. These materials block the bacterial growth thus preventing the biofilms formation. Synergy between thymol and carvacrol grafted onto paper has also been shown. In a second part, our study focused on the development of an antibacterial paper that acquires its activity only after the grafting and formation of "aryl-1,2,3-triazole", the active motif. The grafting is carried out by a reaction of "Click Chemistry", the copper (I)-catalyzed Azide Alkyne Cycloaddition. The antibacterial tests reveal the importance of the aryl substituent, the influence of the contact time and the relevance of using mixtures of materials. The antibacterial activity observed on the thermomechanical pulp fibers is better in both parts. The different results obtained are described in this manuscript