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Journal articles on the topic 'Triazol'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Khomenko, Dmytro, Tetyana Shokol, Roman Doroshchuk, Ilona Raspertova, Rostyslav Lampeka, and Yulian Volovenko. "Strategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles." Chemistry & Chemical Technology 17, no. 2 (2023): 294–303. http://dx.doi.org/10.23939/chcht17.02.294.

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Conjugated heterocyclic compounds with a 1,2,4-triazole core are of scientific interest due to their wide application in both synthetic and medicinal chemistry. In this review, we comprehensively summarize the synthetic methods for [1,2,4]triazolo[1,5-a]pyridine-8-carbonitriles. The methods are classified as follows: convertion of 8-substituted [1,2,4]triazolo[1,5-a]pyridines; synthesis based on functionalized pyridines, containing a nitrile group; synthesis based on heterocyclization of 2-(1,2,4-triazol-5-yl)acetonitriles, including cyclocondensation of 2-(1,2,4-triazol-5-yl)acetonitriles wit

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2

Vashchenko, Oleksandr, Dmytro Khomenko, Roman Doroschuk, Ilona Raspertova, and Rostyslav Lampeka. "Synthesis of 3-(2-Hydroxyphenyl)-5-(2-Pyridinyl)-1,2,4-triazoles as a potential chelate ligand for Uranyl ion." French-Ukrainian Journal of Chemistry 8, no. 2 (2020): 1–6. http://dx.doi.org/10.17721/fujcv8i2p1-6.

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Two new uranyl complexes with the molecular formula [(UO2)(H2L1)](СH3OH) and [(UO2)(H3L2)](СH3OH) {H4L1 = 2-[5-[[5-[[5-(2-pyridyl)-1H-1,2,4-triazol-3‑yl]methyl]-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]phenol and H5L2 = 2-[5-[[5-[[5-[[5-(2-pyridyl)-1H-1,2,4‑triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazol-3-yl]phenol)} have been synthesized. All compounds have been characterized by NMR and IR spectroscopy. With H4L1 and H5L2 uranyl ion forms mononuclear complexes. In [(UO2)(H3L2)](СH3OH) pyridyl nitrogen was uncoordinated and bonding

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3

Marchenko, Roman D., and Andrei S. Potapov. "Synthesis of Bis(1,2,3-triazolyl)alkanes in Superbasic and Solvent-Free Conditions." Molbank 2023, no. 1 (2023): M1551. http://dx.doi.org/10.3390/m1551.

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Nucleophilic substitution reactions between 1,2,3-triazole and dibromomethane or 1,2-dirbomoethane in a superbasic medium potassium hydroxide–dimethyl sulfoxide gave mixtures of the isomeric bis(1,2,3-triazolyl)alkanes, in which (1,2,3-triazol-1-yl)(1,2,3-triazol-2-yl)alkanes and bis(1,2,3-triazol-2-yl)alkanes were the dominating products, while bis(triazol-1-yl)alkanes were detected only in trace amounts. The same products could also be obtained under solvent-free conditions in a neat reaction mixture. The proposed methods are economically feasible, do not require using toxic solvents or cata

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4

Nahlé, A., R. Salim, F. El Hajjaji, et al. "Novel triazole derivatives as ecological corrosion inhibitors for mild steel in 1.0 M HCl: experimental & theoretical approach." RSC Advances 11, no. 7 (2021): 4147–62. http://dx.doi.org/10.1039/d0ra09679b.

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The present paper illustrates the investigation of two novel ecological triazole derivative corrosion inhibitors, namely ethyl 2-(4-phenyl-1H-1,2,3-triazol-1-yl) acetate [Tria-CO<sub>2</sub>Et], and 2-(4-phenyl-1H-1,2,3-triazol-1-yl) acetohydrazide [Tria-CONHNH<sub>2</sub>].

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5

Hryhorka, H. V., М. М. Fizer, О. І. Fizer, A. O. Kryvoviaz, and M. V. Slivka. "SYNTHESIS AND CHEMICAL PROPERTIES OF 2-HEPTADECYL-[1,3]THIAZOLO[3,2-b][1,2,4]TRIAZOL-7-IUM CATION." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 67–72. http://dx.doi.org/10.24144/2414-0260.2022.2.67-72.

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Functional and condensed derivatives of 1,2,4-triazoles are mostly used as biologically active compounds, and modern studies increasingly report their successful use as surfactants, stabilizers for the formation of nanoparticles, components of hybrid perovskites, which are promising materials for opto-electronics. Synthesis of new [1,3]thiazolo[3,2-b][1,2,4]triazol-7-ium salts containing a long-chain heptadecyl substituent was proposed within our research. The production of the starting compounds (2-heptadecyl-4-methyl-1,2,4-triazole-3-thione and methallyl thioether of 2-heptadecyl-3-mer

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6

Safonov, A. A. "Synthesis, physico-chemical properties of derivatives 3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amine." Farmatsevtychnyi zhurnal, no. 3-4 (August 14, 2018): 50–54. http://dx.doi.org/10.32352/0367-3057.3-4.16.03.

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Recently, the search for new compounds with high biological activity, which can be the basis for potential drugs, becomes topical for world scientists. A heterocyclic compound cause particular interest in this area as highly pharmacologically active compounds. Scientists extends interest due to the low toxicity and high reactivity 1,2,4-triazole of the system. It is proved that the combination of triazole nucleus with other heterocyclic systems, especially in the fifth position, causes increased biological effect, and, sometimes, the appearance of new pharmacological activities. The aim

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7

Panchal, Ashvin D., and Pravin M. Patel. "Synthesis ofN-(5-(Substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine from 4-Amino-4H-1,2,4-triazole." E-Journal of Chemistry 8, no. 3 (2011): 1180–85. http://dx.doi.org/10.1155/2011/658708.

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N-(4H-1,2,4-Triazol-4-yl)acetamide (2) were prepared by reaction of 4-amino-4H-1,2,4-triazole (1) with acetyl chloride in dry benzene. It has been reacted with various aromatic aldehyde to afford 3-(substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide (3a-e). The synthesis ofN-(5-substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine (4a-e) is achieved by the cyclisation of3a-ewith hydrazine hydrate in ethanol. The structures of synthesized compounds were characterized by1H NMR and IR spectroscopic studies. The purity of the compounds was checked by thin layer chromatograph

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8

Abdel-Wahab, Bakr F., Ahmed F. Mabied, James C. Fettinger, and Abdelbasset A. Farahat. "2-((4-Amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one." Molbank 2023, no. 3 (2023): M1720. http://dx.doi.org/10.3390/m1720.

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The reaction of 2-bromo-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (1) with 4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazole-3-thiol (2) in absolute ethanol in the presence of triethyl amine as catalyst gave 2-((4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (3) in 73% yield. The structure of the title heterocycle (3) was confirmed by X-ray single crystal diffraction and spectral analyses (NMR and IR).

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9

Adamchyk, S. V., and A. L. Michal’chuk. "Potential aromatase inhibitors and antiestrogen agents based on stilbene and stilbazole derivatives." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 56, no. 1 (2020): 81–87. http://dx.doi.org/10.29235/1561-8331-2020-56-1-81-87.

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Abstract. Widely used forms of endocrine therapy for women with hormone-dependent breast cancer include blocking the biosynthesis of estrogens through using inhibitors of cytochrome P450 19A1 (aromatase). A series of new stilbene and stilbazole based aromatase inhibitors on are prepared. Z-isomers of 4-(2-(pyridin-4-yl)-1-(1H-1,2,4-triazol-1-yl)vinyl) benzonitrile, 4-(2-(pyridin-3-yl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile, 4-(2-(4-fluorophenyl)-1-(1H-1,2,4-triazol1-yl)vinyl)benzonitrile, 4-(2-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile, 4-(2-(4-bromophenyl)-1-(1H-1,2,4tr

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10

Xiao, Pan-Lei, Xiu-Ying Song, Xin-Ting Xiong, Da-Yong Peng, and Xu-Liang Nie. "Synthesis, Crystal Structure, Spectral Characterization and Antifungal Activity of Novel Phenolic Acid Triazole Derivatives." Molecules 28, no. 19 (2023): 6970. http://dx.doi.org/10.3390/molecules28196970.

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At present, phenolic acid derivatives and triazole derivatives have a good antifungal effect, which has attracted widespread attention. A series of novel phenolic acid triazole derivatives were synthesized, and their structures were characterized by IR, MS, NMR, and X-ray crystal diffraction. Compound methyl 4-(2-bromoethoxy)benzoate, methyl 4-(2-(1H-1,2,4-triazol-1-yl) ethoxy)benzoate, 4-(2-(1H-1,2,4-triazol-1-yl)ethoxy)benzoic acid and 4-(2-(1H-1,2,4-triazol-1-yl) ethoxy)-3-methoxybenzoic acid crystallize in the monoclinic system with space group P21/n, the monoclinic system with space group

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11

Srinivasa Reddy, T., Hitesh Kulhari, V. Ganga Reddy, et al. "Synthesis and biological evaluation of pyrazolo–triazole hybrids as cytotoxic and apoptosis inducing agents." Organic & Biomolecular Chemistry 13, no. 40 (2015): 10136–49. http://dx.doi.org/10.1039/c5ob00842e.

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A series of pyrazolo–triazole hybrids were designed and synthesized by combining the 1,3-diphenyl pyrazole and triazole scaffolds to obtain (1-benzyl-1H-1,2,3-triazol-4-yl)(1,3-diphenyl-1H-pyrazol-4-yl)methanones.

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12

Bai, Shi-Qiang, Lu Jiang, David James Young, and T. S. Andy Hor. "Hybrid 1,2,3-Triazole Supported CuII Complexes: Tuning Assembly and Weak Interaction-Driven Crystal Growth." Australian Journal of Chemistry 69, no. 4 (2016): 372. http://dx.doi.org/10.1071/ch15650.

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Two new dinuclear CuII complexes [Cu2Cl4(L1)2] (1) and [Cu2Cl4(L2)2] (2) (L1 = 2-((4-(2-(cyclopentylthio)ethyl)-1H-1,2,3-triazol-1-yl)methyl)pyridine; L2 = 2-((4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl)benzonitrile) were synthesised and characterised by single-crystal X-ray diffraction (XRD), powder XRD, thermogravimetric analysis, elemental analysis and IR measurements. The picolyl-triazole ligand L1 coordinates in a chelate-bridging mode forming a dinuclear structure 1. The more rigid pyridyl-triazole ligand L2 chelates only, generating a chloride-bridged dinuclear complex 2. Both crysta

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13

Karpun, Yevhen, and Nataliia Polishchuk. "Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol." ScienceRise: Pharmaceutical Science, no. 3(31) (June 30, 2021): 64–69. http://dx.doi.org/10.15587/2519-4852.2021.235976.

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The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)t

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14

Childs, Bradley J., Donald C. Craig, Marcia L. Scudder, and Harold A. Goodwin. "Coordination of the Strong Field Terimine System 6-Triazol-3-yl-2,2′-bipyridine and Substituted Derivatives. Electronic and Structural Properties of Bis(ligand)iron(II) Complexes." Australian Journal of Chemistry 51, no. 10 (1998): 895. http://dx.doi.org/10.1071/c97202.

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A terminal pyridine ring in terpyridine has been replaced by a triazole or substituted triazole moiety to give the tridentates 6-(1,2,4-triazol-3-yl)-2,2´-bipyridine, 6-(1-methyl-1,2,4-triazol-3-yl)-2,2´-bipyridine, 6-(5-methyl-1,2,4-triazol-3-yl)-2,2´-bipyridine and 6-(1,5-dimethyl-1,2,4-triazol-3-yl)-2,2´-bipyridine. The effects of coordination of these on the electronic and structural properties of the [FeN6]2+ species are considered. The primary effect is a reduction in the ligand field but salts of the [FeN6]2+ derivatives are essentially low spin (singlet ground state) at room temperatur

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15

Nami, Navabeh, Mehdi Forozani, Vida Khosravimoghadam, and Rahmatallah Taherinasab. "Synthesis and Characterization of Mono- and Bicycle Heterocyclic Derivatives Containing 1, 2,4-Triazole, 1,3,4-Thiadiazine and 1,3-Thiazole Rings." E-Journal of Chemistry 9, no. 1 (2012): 161–66. http://dx.doi.org/10.1155/2012/867637.

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Reaction of tartaric acid with thiocarbohydrazide(2)and thiosemicarbazide(6)afforded 1,2-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-ethane-1,2-diol(3)and 1,2-bis(5-mercapto-4H-1,2,4-triazol-3-yl)-ethane-1,2-diol(7). Reaction of compounds3and7with DMAD (dimethylacety lendi carboxylate) and DEAD (diethylacetylendicarboxylate) gave 1,2-bis(7-[(z)-methoxycarbonylmethylen]-5,6-dihydro-5H-6-one-[1,2,4] riazolo[3,4-b] [1,3,4] thiadiazin-3-yl)-ethan-1,2-diol(4), 1,2-bis(7-[(z)-ethoxycarbonylmethylen] -5,6-dihydro -5H-6-one-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-ethan-1,2- diol(5)and 1,2-bis(

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16

Liu, Feng-Yi, Dong-Mei Zhou, Xiao-Lan Zhao, and Jun-Feng Kou. "Complexes of nickel(II) and copper(II) with 1,2,4-triazole-3-carboxylic acid and of cobalt(III) with 3-amino-1,2,4-triazole-5-carboxylic acid." Acta Crystallographica Section C Structural Chemistry 73, no. 11 (2017): 1010–16. http://dx.doi.org/10.1107/s2053229617012943.

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Because of their versatile coordination modes and strong coordination ability for metals, triazole ligands can provide a wide range of possibilities for the construction of metal–organic frameworks. Three transition-metal complexes, namely bis(μ-1,2,4-triazol-4-ide-3-carboxylato)-κ3 N 2,O:N 1;κ3 N 1:N 2,O-bis[triamminenickel(II)] tetrahydrate, [Ni2(C3HN3O2)2(NH3)6]·4H2O, (I), catena-poly[[[diamminediaquacopper(II)]-μ-1,2,4-triazol-4-ide-3-carboxylato-κ3 N 1:N 4,O-[diamminecopper(II)]-μ-1,2,4-triazol-4-ide-3-carboxylato-κ3 N 4,O:N 1] dihydrate], {[Cu2(C3HN3O2)2(NH3)4(H2O)2]·2H2O} n , (II), (μ-5

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17

Yevhen, Karpun, and Polishchuk Nataliia. "Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol." ScienceRise: Pharmaceutical Science, no. 3(31) (June 30, 2021): 64–69. https://doi.org/10.15587/2519-4852.2021.235976.

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<strong>The aim of the work.</strong> 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1

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18

Onisko, Mikhailo. "ARYLTELLUROCHLORINATION OF 5-ARYL(HETERYL)SUBSTITUTED N-ALLYL-1,2,4-TRIAZOLE-3-THIONE DERIVATIVES." Ukrainian Chemistry Journal 89, no. 8 (2023): 109–16. http://dx.doi.org/10.33609/2708-129x.89.08.2023.109-116.

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Condensed heterocycles based on 1,2,4-triazole have a wide range of biological activity. The introduction of a pharmacophore fragment of an aryl tertiary residue into their composition can significantly increase the bioactivity of the obtained compounds. Therefore, the synthesis of condensed derivatives of symmetrical 1,2,4-triazole with aryltellurium fragment is an urgent task. One of the most convenient and effective methods for introducing an aryltellurium fragment into such systems is the method of electrophilic intramolecular cyclisation of alkenyl derivatives of azaheterocycles. The aim

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19

Nurhan G mr k o lu, Nurhan G. mr k. o. lu, and Muhammad Imran and Inam Iqbal Muhammad Imran and Inam Iqbal. "Synthesıs and Characterızatıon of New Trıazole and Coumarın-Derived Heterocyclıc Compounds Part I." Journal of the chemical society of pakistan 41, no. 6 (2019): 1097. http://dx.doi.org/10.52568/000830/jcsp/41.06.2019.

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Synthesis of ethyl ester of acetic acid containing 5-oxo-[1,2,4] triazole ring (2) was achieved by the condensation of 3-substituted-4-amino-1H-1,2,4-triazol-5(4H)-one (1) with ethyl bromoacetate in basic medium. Compound 2, was then further reacted with hydrazine hydrate to form acid hydrazide, which is 2-(4-amino-3-substituted-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetohydrazide (3). Compound 3 was later treated with three different diverse coumarin aldehydes (6, 12, 18) resulted in the formation of arylidene hydrazides as cis–trans conformers (7, 8, 13, 14, 19, 20). In conclusion, we synt

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20

Šermukšnytė, Aida, Kristina Kantminienė, Ilona Jonuškienė, Ingrida Tumosienė, and Vilma Petrikaitė. "The Effect of 1,2,4-Triazole-3-thiol Derivatives Bearing Hydrazone Moiety on Cancer Cell Migration and Growth of Melanoma, Breast, and Pancreatic Cancer Spheroids." Pharmaceuticals 15, no. 8 (2022): 1026. http://dx.doi.org/10.3390/ph15081026.

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4-Phenyl-3-[2-(phenylamino)ethyl]-1H-1,2,4-triazole-5(4H)-thione was used as a starting compound for the synthesis of the corresponding 1,2,4-triazol-3-ylthioacetohydrazide, which reacts with isatins and various aldehydes bearing aromatic and heterocyclic moieties provided target hydrazones. Their cytotoxicity was tested by the MTT assay against human melanoma IGR39, human triple-negative breast cancer (MDA-MB-231), and pancreatic carcinoma (Panc-1) cell lines. The selectivity of compounds towards cancer cells was also studied. In general, the synthesized compounds were more cytotoxic against

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21

Ravikumar, Krishnan, Balasubramanian Sridhar, Jagadeesh Babu Nanubolu, Venkatasubramanian Hariharakrishnan, and Awadesh Narain Singh. "Structures of benzoxazine-fused triazoles as potential diuretic agents." Acta Crystallographica Section C Crystal Structure Communications 68, no. 8 (2012): o302—o307. http://dx.doi.org/10.1107/s0108270112029800.

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6,8-Dinitro-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-1-one, C9H5N5O6, (I), a potential diuretic, and its acetylacetone derivative (E)-2-(2-hydroxy-4-oxopent-2-en-3-yl)-6,8-dinitro-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-1-one, C14H11N5O8, (II), both crystallize from methanol but in centrosymmetric and noncentrosymmetric space groups, respectively. To the best of our knowledge, this is the first report of crystal structures of benzoxazine–triazole fused systems. The acetylacetone group in (II) exists as the keto–enol tautomer and is oriented perpendicular to the

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22

Maliszewska-Guz, Alicja, Monika Wujec, Monika Pitucha, et al. "Cyclization of 1-{[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}thiosemicarbazides to 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives and Their Pharmacological Properties." Collection of Czechoslovak Chemical Communications 70, no. 1 (2005): 51–62. http://dx.doi.org/10.1135/cccc20050051.

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By the reaction of 4-methyl-4H-1,2,4-triazole-3-thiol with ethyl bromoacetate, ethyl [(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate (1) was obtained. This compound was converted to [(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide (2). In the reaction of 2 with isothiocyanates, new thiosemicarbazides 3a-3g were obtained. The cyclization of 3a-3g in 2% aqueous solution of sodium hydroxide led to the formation of 4H-1,2,4-triazole-3(2H)-thione derivatives 4a-4g, whereas the cyclization in acid media led to the formation of 2-amino-1,3,4-thiadiazole derivatives 5a-5g. Molecular structur

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23

Pavlov, Dmitry, Taisiya Sukhikh, Evgeny Filatov, and Andrei Potapov. "Facile Synthesis of 3-(Azol-1-yl)-1-adamantanecarboxylic Acids—New Bifunctional Angle-Shaped Building Blocks for Coordination Polymers." Molecules 24, no. 15 (2019): 2717. http://dx.doi.org/10.3390/molecules24152717.

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For the first time, orthogonally substituted azole-carboxylate adamantane ligands were synthesized and used for preparation of coordination polymers. The angle-shaped ligands were prepared by the reaction of 1-adamantanecarboxylic acid and azoles (1H-1,2,4-triazole, 3-methyl-1H-1,2,4-triazole, 3,5-dimethyl-1H-1,2,4-triazole, 1H-tetrazole, 5-methyl-1H-tetrazole) in concentrated sulfuric acid. Variation of the solvent and substituents in azole rings allowed to prepare both 1D and 2D copper(II) and nickel(II) coordination polymers, [Cu2(trzadc)4(H2O)0.7]∙DMF∙0.3H2O, [Cu(trzadc)2(MeOH)]∙MeOH, [Ni(

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Бакумовська, Х. Д., and А. С. Гоцуля. "Synthesis and properties of 7-((6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)methyl)theophyllines." Farmatsevtychnyi zhurnal, no. 1 (February 27, 2023): 58–65. http://dx.doi.org/10.32352/0367-3057.1.23.06.

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The creation of new biologically active compounds is a promising area of modern medicinal chemistry. Heterocyclic systems play an important role in this process.Among them, it is necessary to note 1,2,4-triazole and xanthine, the presence of which in the structure of known medicines determines their pharmacological activity. The combination of these heterocycles within a single molecule can lead to the enhancement of the existing biological effect or the emergence of new useful properties. The aim of the work has been to synthesize new theophylline-containing 4-amino-1,2,4-triazole-3-thi

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25

Yin, Ping, Jiaheng Zhang, Damon A. Parrish, and Jean'ne M. Shreeve. "Energetic fused triazoles – a promising C–N fused heterocyclic cation." Journal of Materials Chemistry A 3, no. 16 (2015): 8606–12. http://dx.doi.org/10.1039/c5ta01329a.

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A family of new energetic 3,6,7-triamino-7H-[1,2,4]triazolo[5,1-c][1,2,4]triazol-2-ium salts was developed as promising energetic materials with a high-nitrogen C–N fused framework as the energetic cation.

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Chandrasekhar, Attoor, Venkatachalam Ramkumar, and Sethuraman Sankararaman. "Palladium catalyzed carbonylative annulation of the C(sp2)–H bond of N,1-diaryl-1H-tetrazol-5-amines and N,4-diaryl-4H-triazol-3-amines to quinazolinones." Organic & Biomolecular Chemistry 16, no. 44 (2018): 8629–38. http://dx.doi.org/10.1039/c8ob02516a.

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Pd(ii) catalyzed direct C–H carbonylative annulation of N,1-diaryl-1H-tetrazol-5-amines and N,4-diaryl-4H-1,2,4-triazol-3-amines gave the corresponding triazole and tetrazole fused quinazolinones in good yields.

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Yilmaz, Fatih. "Synthesis and Characterisation of Some New Hybrid Molecules Containing Thiophene, Triazole and Coumarin Rings under Microwave Conditions." Journal of Chemical Research 42, no. 7 (2018): 361–65. http://dx.doi.org/10.3184/174751918x15314831778603.

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In this work, a new series of N‘-{[4-amino-5-oxo-3-(thiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-2-oxo-2H-1-benzopyran-3-carbohydrazides (thiophene–triazole–coumarin hybrid molecules) was synthesised from the reaction of 2-[4-amino-5-oxo-3-(thiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetohydrazide and 3-(1H-benzotriazol-1-ylcarbonyl)-2H-chromen-2-ones by using microwave irradiation and conventional heating procedures and their results were compared. The reaction was performed using a very small amount of organic solvent and without using a catalyst.

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Holota, Serhii, Yaroslav Shylych, Halyna Derkach, Olexandr Karpenko, Andrzej Gzella, and Roman Lesyk. "Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one." Molbank 2018, no. 4 (2018): M1022. http://dx.doi.org/10.3390/m1022.

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4-(1H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one (4) was synthesized with a yield of 55% via ring-switching hydrazinolysis of 5-ethoxymethylidenethiazolo[3,2-b][1,2,4] triazol-6-one (3) in ethanol medium. The initial 1H-[1,2,4]-triazole-3-thiol (1) was modified via a two-step reaction: S-alkylation with chloroacetic acid under Williamson reaction conditions, and further one-pot cyclization–condensation with triethylorthoformate in the acetic anhydride medium, yielding compound 3. The structures of compounds 3 and 4 were confirmed by LC-MS, NMR spectra and a single X-ray diffraction

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Almehmadi, Mazen, Mamdouh Allahyani, Ayman Al-hazmi, and Mohammad Asif. "Synthesis and in vitro anti-bacterial evaluation of some 3-((4-(4-(arylideneamino)-5-mercapto-4H-1,2,4- triazol-3-yl)phenyl)imino)isoindolin-1-one derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 135. https://doi.org/10.59467/ijhc.2025.35.135.

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Some 3-((4-(4-(arylideneamino)-5-mercapto-4H-1,2,4-triazol-3-yl)phenyl)imino)isoindolin-1-one derivatives (3a-e) were synthesized by the reaction of 3-((4-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)phenyl)imino)indolin-2-one (2) with aryl aldehydes. The in vitro anti-bacterial activity of the synthesized compounds was tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Some compounds (3a-c) exhibited satisfactory antibacterial efficacy against tested bacteria. The most effective compound against tested bacteria was compound 3a.. KEYWORDS :Indoledi

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30

Shcherbyna, Roman, Volodymyr Parchenko, Boris Varynskyi, and Andriy Kaplaushenko. "The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio) acetate substance." Current Issues in Pharmacy and Medical Sciences 32, no. 1 (2019): 5–9. http://dx.doi.org/10.2478/cipms-2019-0001.

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Abstract Derivatives of 1,2,4-triazole are actively researched by scientists and synthetic pharmacologists. The last studies have shown that potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate with low toxicity series exhibits antioxidant and hepatoprotective properties. Therefore, the purpose of this work was to develop a method for determining the API in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate substance using the method of high-performance liquid chromatography with diode array detection (HPLC-DAD). As a result of this work,

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Bai, Hui, Xuelian Liu, Pengfei Chenzhang, Yumei Xiao, Bin Fu, and Zhaohai Qin. "Design, Synthesis and Fungicidal Activity of New 1,2,4-Triazole Derivatives Containing Oxime Ether and Phenoxyl Pyridinyl Moiety." Molecules 25, no. 24 (2020): 5852. http://dx.doi.org/10.3390/molecules25245852.

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A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety were designed and synthesized. The new compounds were identified by nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). Compound (Z)-1-(6-(4-nitrophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a18) was further confirmed by X-ray single crystal diffraction. Their antifungal activities were evaluated against eight phytopathogens. The in vitro bioassays indicated that most of the title compounds displayed moderate to high fungicidal a

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32

Muhammad Arfan, Muhammad Arfan, Sabahat Zahra Siddiqui Sabahat Zahra Siddiqui, Muhammad Athar Abbasi Muhammad Athar Abbasi, et al. "Synthesis, Spectral Evaluation and in Silico Studies of S-Aralkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols: As suitable Alzheimerand#39;s disease drug candidates." Journal of the chemical society of pakistan 43, no. 6 (2021): 694. http://dx.doi.org/10.52568/000974/jcsp/43.06.2021.

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Our efforts lay emphasis on synthesis of S-aralkylated 5-(4-OMeC6H5)-4-phenyl-4H-1,2,4-triazol-3-thiols like pharmacologically active candidates to counter neurodegenerative disorder; Alzheimerand#39;s disease. A synthetic strategy was instigated by esterifying 4-methoxybenzoic acid through Fisher esterificationand#39;s methodology. Hydrazinolysis of corresponding ester was performed under reflux with methanolic hydrated hydrazine to afford 4-methoxybenzohydrazide (I) which refluxing with phenyl isothiocyanate (II) in MeOH to yield a reactive intermediate (III). The later underwent base-cataly

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33

Kalchenko, V. V., and R. O. Shcherbyna. "Computer prediction of toxicity of new S-alkyl derivatives of 1,2,4-triazole." Current issues in pharmacy and medicine: science and practice 17, no. 3 (2024): 253–56. http://dx.doi.org/10.14739/2409-2932.2024.3.312927.

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1,2,4-Triazole derivatives are of researchers’ significant interest due to their diverse biological properties, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant activities. The integration of a 2-bromo-4-fluorophenyl fragment into the triazole structure can significantly enhance these activities. However, the evaluation of the toxicity of such compounds remains a critically important aspect for their practical application. To reduce the time and cost of experimental studies, QSAR (Quantitative Structure-Activity Relationship) methods are actively used, allowing the predict

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34

Yang, Tingting, Xin Shi, Libing Guo, et al. "Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties." Journal of Chemical Research 43, no. 7-8 (2019): 241–47. http://dx.doi.org/10.1177/1747519819857479.

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A new series of paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties were synthesized and evaluated for their cytotoxicity in vitro against human non-small cell lung cancer NCI-H1299 cells and human cervical carcinoma HeLa cells. Among them, compared with that of paeonol, compounds 8-acetyl-4-{[(1-(5-chloro-2-nitrophenyl)-1 H-1,2,3-triazol-4-yl]methyl}-5-methoxy-2 H-1,4-benzoxazin-3(4 H)-one, 8-acetyl-4-[(1-mesityl-1 H-1,2,3-triazol-4-yl)methyl]-5-methoxy-2 H-1,4-benzoxazin-3(4 H)-one, and 8-acetyl-5-methoxy-4-{[(1-(naphthalen-1-yl)-1 H-1,2,3-triazol-4-yl]methyl}-2

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35

Rjabova, Jekaterina, Vitālijs Rjabovs, Antonio Moreno Vargas, Elena Clavijo, and Māris Turks. "Synthesis of novel 3-deoxy-3-C-triazolylmethyl-allose derivatives and evaluation of their biological activity." Open Chemistry 10, no. 2 (2012): 386–94. http://dx.doi.org/10.2478/s11532-012-0002-9.

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AbstractRecently, monosaccharide-triazole conjugates have proved to possess a large variety of useful biological activities. This paper describes synthesis of a new series of 3-deoxy-3-C-triazolylmethyl-allose derivatives. These new compounds are obtained from acetonide-protected 3-deoxy-3-azidomethyl allose and commercial alkynes via Cu(I) catalyzed 1,3-dipolar cycloaddition. The obtained molecular scaffolds differ from those described earlier by the presence of a methylene linker (-CH2-) between the C(3) of allose and the triazole moiety. It was demonstrated that acetonide-protected monosacc

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36

Stankovičová, Henrieta, Renata Gašparová, Margita Lácová, and Jarmila Chovancová. "Reaction of 4-Oxochromene-3-carboxaldehydes with Primary Amides and Benzotriazole or 1H-1,2,4-Triazole." Collection of Czechoslovak Chemical Communications 62, no. 5 (1997): 781–90. http://dx.doi.org/10.1135/cccc19970781.

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N-[(6-substituted-4-oxochromen-3-yl)(1,2,4-triazol-3-yl)methyl]amides 5 and N-[(6-substituted-4-oxochromen-3-yl)(benzotriazol-1-yl)methyl]amides 6 were prepared by the reaction of 6-substituted 4-oxochromene-3-carboxaldehydes 1 with primary amides and 1H-1,2,4-triazole or 1H-benzotriazole. 6-Substituted 3-[hydroxy(1,2,4-triazol-1-yl)methyl]chromen-4-one 2 and 6-substituted 3-[hydroxy(benzotriazol-1-yl)methyl]chromen-4-one 3 were isolated as stable intermediates of these reactions. Beneficial effect of microwave irradiation on length of reaction time was observed. Some reactions of these deriva

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37

Zaid Mahmood Mohammed and Ayad Abed Ali Al-Hamashi. "Molecular Docking, Molecular Dynamic Simulation, ADMET, Synthesis, and Preliminary Cytotoxic Activity of New Triazole-Based Derivatives with Expected Histone Deacetylase Inhibition Activity." Iraqi Journal of Pharmaceutical Sciences 33, (4SI) (2025): 101–10. https://doi.org/10.31351/vol33iss(4si)pp101-110.

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Targeting histone deacetylase enzymes (HDACs) is an effective way to treat a variety of diseases, including cancer. A number of HDAC inhibitors (HDACi) have been clinically used. Most of the clinically used HDACi are pan-inhibitors and have poor pharmacokinetic properties. Therefore, several attempts are ongoing to develop new HDACis with optimum structural features to overcome the structural limitations. In this work, six new triazole-based compounds (k1-k6) were proposed via special modification of common pharmacophores of HDACi using 1,2,4-triazole as a zinc-binding group (ZBG), diverse gro

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38

Armasu, Svetlana, Dumitru Terteac, Vitalie Cebanu, et al. "Evaluation of the antifungal action of some new 1,2,4-1h-triazole derivatives against vine anthracnosisin in vitro conditions." Akademos, no. 2(69) (August 2023): 75–80. http://dx.doi.org/10.52673/18570461.23.2-69.08.

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The article presents the results of an in vitro study of the toxic effect of some new compounds of the triazole group on the causal agent of grapevine anthracnose – Gloeosporium ampelophagum. The newly synthesized compound (Z)-1-(2,4-dichlorophenyl)-5-methyl-2-(1H-1,2,4-triazol-1-yl)hex-1-en-3-one showed a pronounced antifungal action (99.5 %) compared to the closest triazole analogue – propiconazole.

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39

Khomenko, D., R. Doroschuk, I. Odarych, I. Raspertova, and R. Lampeka. "CATECHOLASE ACTIVITY OF A COPPER(II) COMPLEX WITH THE 2-(5-(1,2,4)TRIAZOLE-1-ILMETHYL-1H-(1,2,4)-TRIAZOLE-3-IL)-PYRIDYL." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1 (57) (2020): 19–22. http://dx.doi.org/10.17721/1728-2209.2020.1(57).5.

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Methods of the synthesis of 2-(5-(1,2,4)triazol-1-ylmethyl-1H-(1,2,4)-triazol-3-yl)-pyridine and a binuclear copper complex are described. The structure of the complex is established by X-ray structural analysis. The complex is a centrosymmetric [Cu2(L)2(NO3)2·2H2O]·H2O dimer. The Cu-Cu distance is 4.0408 (3) Å. In the complex the ligand is in a deprotonated state. Due to this, the triazole fragment acts as a bridge between the two metal centers. Copper ions are in an octahedral environment. The equatorial plane is formed by three triazole nitrogen atoms and one pyridyl nitrogen atom. The axia

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40

Md, Akram* Abdul Sayeed Mohd Waseem Akram MD Ather Ali Soherwardi. "STUDIES ON THE SYNTHESIS OF SOME NEW 1,2,4- TRIAZOLES DERIVATIVES AND EVALUATION FOR THEIR ANTI-FUNGAL ACTIVITY PROFILES." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2234–48. https://doi.org/10.5281/zenodo.839545.

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The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3- hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a- 6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4- yl)isonicotinamide (5) and aliphatic dica

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41

Pradip, P. Deohate, and R. Kawle Pravin. "Synthesis and antimicrobial screening of novel bis-triazolo-dithiadiazines containing bridgehead nitrogen." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 911–14. https://doi.org/10.5281/zenodo.5636751.

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Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001, Maharashtra, India <em>E-mail</em> : pradip222091@yahoo.co.in 1,4-Bis-(3-arylimino-[1,2,4]-triazolo-[3,4-c]-[1,2,4,5]-dithiadiazin-6-yl)-benzenes have been synthesized by treating 1,4-bis-(4-amino-3-mercapto-<em>4H</em>-[1,2,4]-triazol-5-yl-benzene with <em>N-aryl</em>-S-chloro isothiocarbamoyl chlorides and then basification with dilute ammonia solution. Synthesis of 1,4-bis-(4-amino-3-mercapto-<em>4H</em>-[1,2,4]-triazol-5-yl-benzene was carried out by interacting the terephthalic acid dihydraz

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42

Dobosz, Maria, Monika Pitucha, Izabela Dybala, and Anna E. Kozioł. "Cyclization of Semicarbazide Derivatives of 3-Methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetic Acid." Collection of Czechoslovak Chemical Communications 68, no. 4 (2003): 792–800. http://dx.doi.org/10.1135/cccc20030792.

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By the reaction of hydrazide of 3-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetic acid (1) with isocyanates, 3-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetosemicarbazide derivatives 2 were obtained. Cyclization of these compounds in the presence of 2% NaOH led to the formation of 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives 3, which was confirmed by X-ray analysis of 3b.

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43

Hamdi, Maamar, Oualid Talhi, Artur Silva, et al. "Synthetic Approach Toward Heterocyclic Hybrids of [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines." Synlett 29, no. 11 (2018): 1502–4. http://dx.doi.org/10.1055/s-0036-1591991.

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The synthesis of novel heterocyclic [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids by a bimolecular reaction of 2-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)phenol with an aromatic or heterocyclic α-bromoacetyl derivatives is described. This synthetic procedure starts from an unprotected phenol.

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44

Lakshman, Mahesh K., Manish K. Singh, Mukesh Kumar, et al. "Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications." Beilstein Journal of Organic Chemistry 10 (August 19, 2014): 1919–32. http://dx.doi.org/10.3762/bjoc.10.200.

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(1H-Benzo[d][1,2,3]triazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), 1H-benzo[d][1,2,3]triazol-1-yl 4-methylbenzenesulfonate (Bt-OTs), and 3H-[1,2,3]triazolo[4,5-b]pyridine-3-yl 4-methylbenzenesulfonate (At-OTs) are classically utilized in peptide synthesis for amide-bond formation. However, a previously undescribed reaction of these compounds with alcohols in the presence of a base, leads to 1-alkoxy-1H-benzo- (Bt-OR) and 7-azabenzotriazoles (At-OR). Although BOP undergoes reactions with alcohols to furnish 1-alkoxy-1H-benzotriazoles, Bt-OTs proved to be superior. Both

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45

Reed, A. N., E. A. Curry, and M. W. Williams. "Translocation of Triazole Growth Retardants in Plant Tissues." Journal of the American Society for Horticultural Science 114, no. 6 (1989): 893–98. http://dx.doi.org/10.21273/jashs.114.6.893.

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Abstract Translocation patterns of the triazole plant growth retardants paclobutrazol, triapenthenol, and BAS111 were found to be similar when applied as a trunk paint, soil drench, or in hydroponic systems. Chemical degradation studies indicate that the greatest percentage of parent compound is translocated to roots and mature leaves following soil drench and hydroponic treatments. Generally, residue levels of BAS111 were significantly lower than those of paclobutrazol and triapenthenol. Data from trunk paint applications indicate triapenthenol and BAS111, even at concentrations 5 times great

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46

Weil, Matthias, and Markus Fürst. "Crystal structure of (1,4-diphenyl-4H-1,2,4-triazol-3-yl)phenylamine difluorophosphate, and a survey of the difluorophosphate anion (PO2F2 −)." Acta Crystallographica Section E Crystallographic Communications 76, no. 7 (2020): 1003–6. http://dx.doi.org/10.1107/s2056989020006933.

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Nitron is the trivial name of (1,4-diphenyl-4H-1,2,4-triazol-3-yl)phenylamine (C20H16N4), a triazole derivative used as an analytical reagent for gravimetric analysis of the nitrate anion. The crystal structure of the difluorophosphate salt of Nitron, 3-anilino-1,4-diphenyl-1H-1,2,4-triazol-4-ium difluorophosphate, C20H17N4 +·PO2F2 −, is reported here. Within the protonated Nitron molecule, the triazole ring, one of the phenyl rings and the NHPh moiety are virtually co-planar, with the third phenyl ring inclined to the least-squares plane of the other three rings by 56.07 (3)°. Intermolecular

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47

Wurfer, Flavius-Gabriel, and Valentin Badea. "(R,S)-2-{[4-(4-Methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl] thio}-1-phenyl-1-ethanol." Molbank 2021, no. 2 (2021): M1231. http://dx.doi.org/10.3390/m1231.

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4-(4-Methoxyphenyl)-5-phenyl--4H-1,2,4-triazole-3-thiol (4) was alkylated to 2-{[4-(-4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenylethan-1-one (5) in alkaline conditions using 2-bromo-1-phenylethanone. The alkylated compound (5) was reduced at the carbonyl group to the corresponding racemic secondary alcohol with an asymmetric carbon, (R,S)-2-{[4-(4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol (6). Both synthesized compounds, ketone (5) and secondary alcohol (6), are new and have not been reported yet in the literature. All the synthesized compounds we

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48

Franco, Daiana Portella, Lucas Caruso, Nathalia Fonseca Nadur, Thiago Moreira Pereira, Renata Barbosa Lacerda, and Arthur Eugen Kümmerle. "Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles." Current Organic Chemistry 25, no. 23 (2021): 2815–39. http://dx.doi.org/10.2174/1385272825666211011111408.

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Triazoles are five-membered aromatic heterocyclics, which exhibit two isosteric forms (1,2,3-triazoles and 1,2,4-triazoles), as well as multiple applications in medicinal, agricultural, supramolecular, and materials sciences. Famous examples of triazoles include drugs, such as fluconazole, ribavirin, cefatrizine, and tazobactam, as well as herbicides, such as cafenstrole and metosulam. This review aims to present the recent major examples of the application of microwave-assisted organic synthesis (MAOS) to the syntheses and endfunctionalizations of 1,4- and 1,5-disubstituted 1,2,3-triazoles, 1

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Youssif, Bahaa G. M., Yaseen A. M. Mohamed, Mohammed T. A. Salim, Fuyuhiko Inagaki, Chisato Mukai, and Hajjaj H. M. Abdu-Allah. "Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus." Acta Pharmaceutica 66, no. 2 (2016): 219–31. http://dx.doi.org/10.1515/acph-2016-0014.

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Abstract New derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized and tested in vitro for antiviral activity against hepatitis C virus (HCV) and hepatitis B virus (HBV). Their cytotoxicity was determined by the reduction in the number of viable cell. All of the synthesized compounds are inactive against HBV and some showed activity against HCV. In particular, two compounds showed significant activity, 2-{4-[(1-benzoylbenzimidazol-2-ylthio)methyl]-1H-1,2,3-triazol-1-yl}-N-(p-nitro-phenyl)-acetamide (13) and 2-(4-{[1-(p-chlorobenzoyl)-benzimidazol-2-yl

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50

Mao, Wen-Zhao, and Jing Chen. "A one-dimensional coordination polymer of 5-(pyridin-2-yl)-3,3′-bi(4H-1,2,4-triazole) with Cd(NO3)2." Acta Crystallographica Section C Crystal Structure Communications 69, no. 9 (2013): 1006–9. http://dx.doi.org/10.1107/s0108270113019999.

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In the title coordination polymer,catena-poly[[(methanol-κO)(nitrato-κO)cadmium(II)]-μ-3-(pyridin-2-yl)-5-(1H-1,2,4-triazol-5-yl)-4H-1,2,4-triazol-4-ido], [Cd(C9H6N7)(NO3)(CH3OH)]n, the asymmetric unit is composed of one CdIIcentre, one nitrate anion, one deprotonated 5-(pyridin-2-yl)-3,3′-bi(4H-1,2,4-triazole) ligand, denoted HBPT−, and one coordinated methanol molecule. Each CdIIion shows an octahedral geometry and is surrounded by four N atoms from two HBPT−ligands in the equatorial plane, and by two O atoms from a monodentate nitrate ligand and a methanol ligand. The structure is a one-dim

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