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Journal articles on the topic 'Triazolo-thiadiazole'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Myrko, Iryna I. "Synthesis and Anti-inflammatory Activity of Some New 6-Aryltriazolo[3,4-b][1,3,4]thiadiazole Derivatives." Journal of Organic and Pharmaceutical Chemistry 22, no. 4 (2024): 17–24. https://doi.org/10.24959/ophcj.24.321751.

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A series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats. 3-(2-Fluorophenyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3c) and 3-(2-fluorophenyl)-6-(4-methoxy-phenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3d) have been identified as hit compounds with the anti-exudative activity. The crucial role of the fluorine atom in the anti-inflammatory activity has been determined, which value considerably correlates with the calculated val

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2

Lelyukh, Maryan, Arkady Savchenko, Myroslava Kalytovska, et al. "Pharmacological profile of condensed heterocyclic compounds based on functionally substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles: A review." Current Chemistry Letters 14, no. 3 (2025): 567–78. https://doi.org/10.5267/j.ccl.2025.3.001.

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Triazolo[3,4-b][1,3,4]thiadiazole molecules are found to be important tools in modern bioorganic and medicinal chemistry. This condensed system successfully combines two pharmacologically significant five-membered heterocycles – 1,2,4-triazole and 1,3,4-thiadiazole, which causes much more interest in the enhanced activity profile of its analogs than their parent separate constituents. It’s considered that the triazoles fused to thiadiazoles exhibit various therapeutically important properties, probably due to the existence of N-C-S fragments in their structures. In this review, we presented th

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3

EL-Mahdy, Ahmed F. M., Hassan A. H. EL-Sherief, Zeinab A. Hozien, and Shiao-Wei Kuo. "A Convenient One-Pot and Rapid Microwave-Assisted Synthesis of Biologically Active s-Triazolo[3,4-b][1,3,4]Thiadiazine and s-Triazolo[3,4-b][1,3,4]Thiadiazole Nanoarchitectonics." Journal of Nanoscience and Nanotechnology 20, no. 5 (2020): 2917–29. http://dx.doi.org/10.1166/jnn.2020.17452.

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A rapid and efficient one-pot protocol has been developed for the synthesis of s-triazolo[3,4-b][1,3,4]thiadiazine and s-triazolo[3,4-b][1,3,4]thiadiazole nanoarchitectonics through the reaction of s-triazoles with ketones and nitriles in acetic acid containing a catalytic amount of sulfuric acid under microwave irradiation in excellent yields. With this catalytic reaction, the cheap sulfuric acid as well as other acids were examined as catalysts and the highly toxic and irritating haloketones and halonitriles were avoided to form. The effects of microwave power, temperature, time, solvent and

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4

El-Sayed, Wael A., Omar M. Ali, Marwa M. Hathoot, and Adel A. H. Abdel-Rahman. "Synthesis and Antimicrobial Activity of New Substituted Fused 1,2,4-Triazole Derivatives." Zeitschrift für Naturforschung C 65, no. 1-2 (2010): 22–28. http://dx.doi.org/10.1515/znc-2010-1-204.

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A number of new substituted 1,2,4-triazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gramnegative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial activities or inhibitory actions.

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5

Vaarla, Krishnaiah, V. Rajeswar Rao, and Mehmet Akkurt. "Crystal structure of 3-benzylsulfanyl-6-(5-methyl-1,2-oxazol-3-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): o809—o810. http://dx.doi.org/10.1107/s2056989015017351.

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In the title compound, C14H11N5OS2, the triazolo–thiadiazole system is essentially planar (r.m.s. deviation = 0.002 Å) and makes dihedral angles of 6.33 (12) and 42.95 (14)° with the planes of the oxazole and phenyl rings, respectively. In the crystal, face-to-face π–π interactions are observed between the thiadiazole and oxazole rings [centroid–centroid distance = 3.4707 (18) Å], leading to columns along [010].

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6

SANGEETA, SUDAN, GUPTA RAJIVE, and L. KACHROO P. "Bridgehead Nitrogen Heterocycles : Synthesis and Biological Activities of s-Triazolo[3,4-b] [1,3,4]thiadiazole System." Journal of Indian Chemical Society Vol. 73, Nov 1996 (1996): 625–26. https://doi.org/10.5281/zenodo.5918317.

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Department of Chemistry, University of Jammu, Jammu-180 004 <em>Manuscript received 27 September 1994, revived 10 March 1995, accepted 15 March 1995</em> Bridgehead Nitrogen Heterocycles : Synthesis and Biological Activities of <em>s</em>-Triazolo[3,4-b] [1,3,4]thiadiazole System.

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7

Trafalis, Dimitrios T., Sofia Sagredou, Panayiotis Dalezis, et al. "Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation." Pharmaceutics 13, no. 4 (2021): 493. http://dx.doi.org/10.3390/pharmaceutics13040493.

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The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties. A series of 1,2,4-triazolo[3,4-b]-1,2,4-thiadiazoles was synthesized and tested for its enzyme inhibition potential and anticancer activity. The results show that 1,2,4-triazolo[3,4-b]-1,2,4-thiadiazoles display potent anticancer properties in vitro against a panel of cancer cells and in vivo efficacy in HT-29 human colon tumor xenograft in CB17 severe combined immunodeficient (SCID) mice. Preliminary mechanistic studies revealed that KA25

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8

Nagaraju, Tumula, Palakodety Radha Krishna, Balasubramanian Sridhar, and Nakka Mangarao. "PhI(OAc)2-Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5-a]pyridines via Oxidative N–S and N–N Bond Formation." Synthesis 51, no. 19 (2019): 3600–3610. http://dx.doi.org/10.1055/s-0037-1611854.

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An effective and expeditious approach for the construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5-a]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc)2]-mediated oxidative cyclization of thioureas/2-aminopyridines and imidates via N–S and N–N bond formation at ambient temperature. This method furnishes the versatile 5-guanidino-1,2,4-thiadiazoles and 1,2,4-triazolo[1,5-a]pyridines in a scalable manner with high efficiency and excellent regioselectivity.

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9

P., D. SINGH, and K. MISHRA L. "Complexes of 2,4-Dimercapto-s triazolo[4,3-b]- 1,3,4-thiadiazole with some Platinum Metal Ions. Part-II." Journal of Indian Chemical Society Vol. 65, Jun 1988 (1988): 447–48. https://doi.org/10.5281/zenodo.6303500.

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Department of Chemistry, Patna University, Patna-800 005 <em>Manuscript received </em><em>10 February</em> <em>1988, </em><em> accepted 25 March 1988</em> Complexes of 2,4-Dimercapto-s triazolo[4,3-b]- 1,3,4-thiadiazole with some Platinum Metal Ions. Part-II.

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10

Lelyukh, Maryan, Andriy Paliy, Maria Zhukrovska, et al. "A review on synthetic approaches for obtaining and chemical modification of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole based heterocyclic compounds." Current Chemistry Letters 13, no. 4 (2024): 737–52. http://dx.doi.org/10.5267/j.ccl.2024.3.007.

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Triazolo[3,4-b]thiadiazoles are a class of heterocyclic compounds, which have attracted great interest in medicinal chemistry owing to their wide range of pharmacological activities. A number of triazoles fused to thiadiazoles are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities. Considering such a significant pharmacological potential, as well as wide synthetic possibilities triazolo-thiadiazoles have received considerable attention from scientiﬁc community and are extensively used for construction of prospective drug

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11

Mekky, Athraa Hameed, Fadil M. Hamed, and Bassam A. Hassan. "Synthesis, Characterization, Molecular Docking Studies and Pharmaceutical Evaluation of some Novel [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole." Jurnal Kimia Valensi 10, no. 2 (2024): 304–14. https://doi.org/10.15408/jkv.v10i2.40043.

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A new series of fused [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole 4a-4e have been synthesized by many steps. Firstly, benzohydrazide [1] has been synthesized from the reaction of methyl benzoate with hydrazine hydrate. Secondly, the cyclization reaction of benzohydrazide with carbon disulfide in the presence of potassium hydroxide produced 5-phenyl-1,3,4-oxadiazole-2-thiol[2]. Thirdly,5-phenyl-1,3,4-oxadiazole-2-thiol[2] was treated with potassium hydroxide using pyridine to give 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol. Finally, the fused [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole 4a-4e were syn

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12

Zhang, Zi-Yi, and Xiao-Wen Sun. "s-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives." HETEROCYCLES 48, no. 3 (1998): 561. http://dx.doi.org/10.3987/rev-97-489.

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13

Fusco, S., R. Centore, P. Riccio, et al. "NLO-active polymers containing triazolo-thiadiazole segments." Polymer 49, no. 1 (2008): 186–91. http://dx.doi.org/10.1016/j.polymer.2007.11.016.

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14

Vekariya, Piyush B., Jalpa R. Pandya, Vaishali Goswami, and Hitendra S. Joshi. "Synthesis and Biological Activity of 1,2,4-Triazolo-[3,4-b]Thiadiazole as Antimicrobial Agents." International Letters of Chemistry, Physics and Astronomy 26 (January 2014): 45–52. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.26.45.

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Some novel 6-fluoro chroman derivatives having 1,2,4-triazolo-[3,4-b]thiadiazole were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using broth dilution method. All the compounds showed good antimicrobial activity and compound 5e showed significant antibacterial activity.

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15

Vekariya, Piyush B., Jalpa R. Pandya, Vaishali Goswami, and Hitendra S. Joshi. "Synthesis and Biological Activity of 1,2,4-Triazolo-[3,4-b]Thiadiazole as Antimicrobial Agents." International Letters of Chemistry, Physics and Astronomy 26 (January 24, 2014): 45–52. http://dx.doi.org/10.56431/p-t014h3.

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Some novel 6-fluoro chroman derivatives having 1,2,4-triazolo-[3,4-b]thiadiazole were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using broth dilution method. All the compounds showed good antimicrobial activity and compound 5e showed significant antibacterial activity.

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16

Altowyan, Mezna Saleh, Matti Haukka, Saied M. Soliman, et al. "Synthesis, Characterization and Single Crystal X-ray Diffraction Analysis of Fused Triazolo/Thiadiazole Clubbed with Indole Scaffold." Crystals 13, no. 3 (2023): 423. http://dx.doi.org/10.3390/cryst13030423.

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The present synthetic strategy involves the synthesis of indolyl-triazolo-thiadiazole heterocyclic ring systems 8–13 from the condensation of 4-amino-5-(1H-indol-2-yl)-3H-1,2,4-triazole-3-thione 1 with the aromatic carboxylic acid derivatives 2–7 in presence of POCl3 for 1 h. All compounds were obtained in very good yields and have been well-characterized using spectroscopic techniques. Exclusively, good quality crystals from the target organic hybrid 8-(1H-indol-2-yl)-5-(p-tolyl)-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazole 9 were obtained and found suitable for X-ray single crystal diffraction

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17

Al-Wahaibi, Lamya H., Hanaa M. Abu-Melha, and Diaa A. Ibrahim. "Synthesis of Novel 1,2,4-Triazolyl Coumarin Derivatives as Potential Anticancer Agents." Journal of Chemistry 2018 (October 14, 2018): 1–8. http://dx.doi.org/10.1155/2018/5201374.

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A series of novel coumarin derivatives carrying 1,2,4-triazole or 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole moieties were prepared and evaluated in vitro as anticancer in the human colon cancer (HCT116) cell line. The derivatives 4c and 8c exhibited marked anticancer activity with IC50 values 4.363 and 2.656 µM, respectively. The molecular docking studies suggested possible interaction with tyrosine kinases (CDK2).

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18

Gündoğdu, Gülsüm, Sevim Peri Aytaç, Melanie Müller, Birsen Tozkoparan, and Filiz Betül Kaynak. "Structure determination of two structural analogs, named 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16F2N4S) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) by synchrotron X-ray powder diffraction." Powder Diffraction 32, no. 4 (2017): 279–89. http://dx.doi.org/10.1017/s0885715617001105.

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Two novel compounds, 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16F2N4S) (1) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) (2), have been designed and synthesized as cytotoxic agents. The compounds were characterized by infrared, proton nuclear magnetic resonance, mass spectral data, elemental analysis and X-ray powder diffraction. The present study comprises spectral data and crystal structures of these novel compounds determined from synchrotron X-ray powder diffraction data

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19

Khan, Mahmood-ul-Hassan, Shahid Hameed, M. Nawaz Tahir, Tanveer Hussain Bokhari, and Islam Ullah Khan. "6-(1-Adamantyl)-3-(2-fluorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1437. http://dx.doi.org/10.1107/s1600536809019692.

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In the title compound, C19H19FN4S, the planes of the 2-fluorophenyl and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole ring systems are oriented at a dihedral angle of 48.98 (6)°. In the crystal, weak C—H...S and C—H...π interactions may help to establish the packing and π–π interactions between the centroids of the benzene rings at a distance of 3.8792 (13) Å occur.

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20

Marupati, Siddhartha, Susmitha Kasula, B. Satheesh, Srinivasa Reddy Bireddy, and Laxminarayana Eppakayala. "Development of an efficient protocol for the synthesis and molecular docking studies of Pyrimidine containing 1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazol‐3‐yl) thio)‐1‐phenylethanone derivatives as promising anticancer agents." Vietnam Journal of Chemistry 60, no. 2 (2022): 169–82. http://dx.doi.org/10.1002/vjch.202100102.

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AbstractPyrimidine containing 1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazol‐3‐yl)thio)‐1‐phenylethanone derivatives shows superior biological activity. In this view, we synthesized a combination of Pyrimidine and triazolo thiadiazole. The target compounds (4a‐o) were synthesized using 5‐methylpyrimidine‐2‐carboxylic acid (1), 4‐amino‐4H‐1,2,4‐triazole‐3,5‐dithiol (2) as starting materials. The prepared compounds were analyzed by spectral analysis and docking studies were carried out into the active site of enzyme dihydrofolate reductase (DHFR), [PDB ID: 3NU0]) using Flare GUI software. The docking ou

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21

ZHANG, Z. Y., and X. W. SUN. "ChemInform Abstract: s-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives." ChemInform 29, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.199826320.

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22

Liu, Xiu-Jian, Lei Wang, Long Yin, et al. "Synthesis and Biological Evaluation of Novel Glycosyl-Containing 1,2,4-Triazolo[3,4-b][1,3,4]Thiadiazole Derivatives as Acetylcholinesterase Inhibitors." Journal of Chemical Research 41, no. 10 (2017): 571–75. http://dx.doi.org/10.3184/174751917x15064232103047.

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An efficient protocol for the synthesis of novel glycosyl-containing 1,2,4-triazolo[3,4- b][1,3,4]thiadiazole derivatives starting from the commercially available D-glucosamine hydrochloride is described by reaction of glycosyl isothiocyanate with various aminotriazoles in DMF. Glycosyl isothiocyanate is an important intermediate and synthetic methods are discussed. The acetylcholinesterase inhibitory activity of these compounds was tested by Ellman's method. It was found that most compounds exhibited over 90% inhibition and they were subsequently evaluated for their IC50 values.

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23

Bui, Thanh-Tu, Hoang-Uy Tan, Hoang-Danh Nguyen, and Tan-Tai Nguyen. "Synthesis of new triazole-fused bicyclic heterocycles involving benzofuran from 4-amino-1,2,4-triazole-3-thiol." Tạp chí Khoa học - Trường Đại học Sư phạm Hà Nội 2 1, no. 2 (2023): 64–69. http://dx.doi.org/10.56764/hpu2.jos.2023.1.2.64-69.

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In the further research and synthesis of hybrid molecules which exhibit highly biological activities, the synthesis of triazole-fused bicyclic heterocycles bearing the benzofuran has been undertaken. A facile, convenient and good yielding synthesis of novel benzofuran-bearing 1,2,4-trazole derivatives were described. Herein, two derivatives of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole were synthesized from salicylaldehyde in four steps in moderate to good yields. Structures of all the targeted synthesized compounds were elucidated by spectral methods of analysis

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24

Nanjunda-Swamy, Shivananju, Basappa, Gangadharaiah Sarala, et al. "Synthesis and X-ray Crystal Studies of 6-(2-chlorophenyl)-3-methyl[1,2,4] triazolo[4,5-b][1,3,4]thiadiazole." Journal of Chemical Research 2005, no. 4 (2005): 238–39. http://dx.doi.org/10.3184/0308234054213456.

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The compound 6-(2-chlorophenyl)-3-methyl[1,2,4]triazolo[4,5-b][1,3,4]thiadiazole, was synthesised using different reagents and conditions, characterised by spectroscopic techniques and finally confirmed by X-ray crystal structure analysis. The title compound crystallises in monoclinic class under the space group P21/c with cell parameters, a=10.6710 (6)Å, b=7.3660 (4)Å, c=14.3900 (8)Å, β=110.403 (3)°, Z=2 and R1= 0.0396 for 2715 reflections [I>2ΣI]. The structure exhibits inter-molecular hydrogen bonding.

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25

Yu, Min, Kang Zhang, Ke-De Qian, Li-Xue Zhang, and Yu-Zhen Liu. "6-Dichloromethyl-3-propyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 63, no. 5 (2007): o2551. http://dx.doi.org/10.1107/s1600536807017400.

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26

Du, Hai-Tang, Hai-Jun Du, and Weiyi Zhou. "3,6-Bis(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (2008): o1577. http://dx.doi.org/10.1107/s1600536808022502.

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27

Jia, Wei-min, Zhi-jian Wang, Xiao-yu Jia, Jing-jing Zhang, and Wei Wang. "3-Methyl-6-trichloromethyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 67, no. 5 (2011): o1093. http://dx.doi.org/10.1107/s1600536811012748.

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28

Çetin, Ahmet. "BAZI YENİ [1,2,4]TRIAZOLO[3,4-b][1,3,4]TİYADİAZOL TÜREVLERİNİN SENTEZİ VE DENEYSEL KARAKTERİZASYONU." e-Journal of New World Sciences Academy 10, no. 3 (2015): 44–50. http://dx.doi.org/10.12739/nwsa.2015.10.3.3a0072.

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29

Kamoutsis, Charalampos, Maria Fesatidou, Anthi Petrou, et al. "Triazolo Based-Thiadiazole Derivatives. Synthesis, Biological Evaluation and Molecular Docking Studies." Antibiotics 10, no. 7 (2021): 804. http://dx.doi.org/10.3390/antibiotics10070804.

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The goal of this research is to investigate the antimicrobial activity of nineteen previously synthesized 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. The compounds were tested against a panel of three Gram-positive and three Gram-negative bacteria, three resistant strains, and six fungi. Minimal inhibitory, bactericidal, and fungicidal concentrations were determined by a microdilution method. All of the compounds showed antibacterial activity that was more potent than both reference drugs, ampicillin and streptomycin, against all bacteria tested. Similarly, they were

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30

Dinçer, Muharrem, Namık Özdemir, Ahmet Çetin, Ahmet Cansız, and Orhan Büyükgüngör. "6-Phenyl-3-(4-pyridyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section C Crystal Structure Communications 61, no. 11 (2005): o665—o667. http://dx.doi.org/10.1107/s0108270105032403.

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31

Huang, Xiao-Bo, Miao-Chang Liu, Li-Xue Zhang, An-Jiang Zhang, Ya-Li Xu, and Miao-Lin Hu. "3-(2-Ethoxyphenyl)-6-phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 61, no. 7 (2005): o2233—o2234. http://dx.doi.org/10.1107/s160053680501901x.

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32

Lei, Xin-Xiang, Xiao-Bo Huang, An-Jiang Zhang, and Li-Xue Zhang. "3-(2-Ethoxyphenyl)-6-(phenoxymethyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 62, no. 10 (2006): o4416—o4417. http://dx.doi.org/10.1107/s1600536806035860.

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33

Holm, Melanie, Dieter Schollmeyer, and Stefan Laufer. "3-(2-Fluorophenyl)-6-(phenoxymethyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 64, no. 4 (2008): o700. http://dx.doi.org/10.1107/s1600536808003917.

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34

Omar, A. Mohsen M. E., and Omaima M. Aboulwafa. "Synthesis andin vitroantimicrobial and antifungal properties of some novel 1,3,4-thiadiazole ands-triazolo[3,4-b][1,3,4]thiadiazole derivatives." Journal of Heterocyclic Chemistry 23, no. 5 (1986): 1339–41. http://dx.doi.org/10.1002/jhet.5570230514.

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35

Chen, Wen-Bin, and Gui-Yu Jin. "SYNTHESES AND BIOLOGICAL ACTIVITIES OF 1,2,4-TRIAZOLO-[3,4-B][1,3,4]THIADIAZOLE DITHIOPHOSPHATES." Phosphorus, Sulfur, and Silicon and the Related Elements 179, no. 3 (2004): 543–49. http://dx.doi.org/10.1080/10426500490422191.

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36

Du, Haitang, Haijun Du, Ying An, and Shengnan Li. "6-(3-Pyridyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (2008): o1402. http://dx.doi.org/10.1107/s1600536808019855.

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Du, Haitang, Haijun Du, Ying An, and Shengnan Li. "6-(2-Methylphenyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (2008): o1481. http://dx.doi.org/10.1107/s160053680802062x.

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Du, Hai-Tang, and Hai-Jun Du. "6-(4-Pyridyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (2008): o1634. http://dx.doi.org/10.1107/s1600536808023544.

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39

Du, Hai-Tang, Hai-Jun Du, and Weiyi Zhou. "6-(4-Methylphenyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 64, no. 10 (2008): o2040. http://dx.doi.org/10.1107/s1600536808030936.

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40

Lei, Xin-Xiang, An-Jiang Zhang, Xiao-Bo Huang, and Li-Xue Zhang. "6-(2-Chlorophenyl)-3-(4-ethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 62, no. 10 (2006): o4418—o4419. http://dx.doi.org/10.1107/s160053680603635x.

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Lin, L., H. Liu, D. J. Wang, Y. J. Hu, and X. H. Wei. "Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives." Bulletin of the Chemical Society of Ethiopia 31, no. 3 (2018): 481. http://dx.doi.org/10.4314/bcse.v31i3.12.

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42

Tahir, M. Nawaz, Mahmood-ul-Hassan Khan, Shahid Hammed, Tanveer Hussain Bokhari, and Saira Hina. "6-(1-Adamantyl)-3-(2-chlorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 67, no. 4 (2011): o1022. http://dx.doi.org/10.1107/s1600536811011391.

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43

Hamdy, Rania, Arwyn T. Jones, Mohamed El-Sadek, et al. "New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents." International Journal of Molecular Sciences 22, no. 22 (2021): 12272. http://dx.doi.org/10.3390/ijms222212272.

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Abstract:

A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a reaction of acyl hydrazide (1) with carbon disulfide in the presence of alcoholic potassium hydroxide to afford the corresponding intermediate potassium thiocarbamate salt (2), which underwent cyclization reaction in the presence of excess hydrazine hydrate to the corresponding triazole thiol (3). Further cyclisation reaction with substitu

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44

Ghosh, Rahul, and Swastika Ganguly. "Synthesis of some new 1-aryl-2-((3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)thio) ethane-1-ones as antimicrobial agents." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 03 (2024): 307. http://dx.doi.org/10.59467/ijhc.2024.34.307.

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A series of ten new 1-(aryl)-2-((3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)thio)ethan-1-ones (4a-j) was synthesized by reacting 3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-6-thiol (2) with substituted phenacyl bromides (3a-j) in the presence of N,N-diisopropylethylamine. These derivatives were comprehensively evaluated for their antimycobacterial, antibacterial, and antifungal activities. Among these, compound 4f demonstrated notable efficacy against mycobacterial, bacterial, and fungal strains, exhibiting performance comparable to standard drugs. Further, highly active compo

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45

El-Khawass, S. M., and N. S. Habib. "Synthesis of 1,2,4-triazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine derivatives of benzotriazole." Journal of Heterocyclic Chemistry 26, no. 1 (1989): 177–81. http://dx.doi.org/10.1002/jhet.5570260131.

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Xu, Xiaoming, Siqi Guo, Jing Zhang, et al. "Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities." Chinese Journal of Organic Chemistry 40, no. 5 (2020): 1345. http://dx.doi.org/10.6023/cjoc201911012.

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47

Qian, Jianhua, Lin Liu, Daolin Wang, and Jinjuan Xing. "Synthesis of 3,6-bisubstituted phenyl-bi-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives." Frontiers of Chemistry in China 2, no. 4 (2007): 428–30. http://dx.doi.org/10.1007/s11458-007-0081-x.

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48

Khan, Mahmood-ul-Hassan, Shahid Hameed, Tashfeen Akhtar, and Helen Stoeckli-Evans. "6-(Adamantan-1-yl)-3-(3-fluorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole." Acta Crystallographica Section E Structure Reports Online 66, no. 12 (2010): o3215—o3216. http://dx.doi.org/10.1107/s1600536810046428.

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Wu, P. "Crystal structure of 6-ferrocenyl-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole." Journal of Structural Chemistry 54, no. 5 (2013): 983–85. http://dx.doi.org/10.1134/s0022476613050223.

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D.K., Ramesh, Gopala Krishna B, Mruthyunjaya J. H., Manjunatha S. Katagi, and Girish Bolakatti. "Synthesis and Antimicrobial Evaluation of Newly Sythesized Triazolothiadiazole Analogs." International Journal of Drug Design and Discovery 4, no. 2 (2025): 1050–55. https://doi.org/10.37285/ijddd.4.2.3.

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Potassium dithiocarbazinate of isonicotinic acid hydrazide 1a was treated with hydrazine hydrate to yield 1,2,4-triazole 1b which up on treatment with various carboxylic acids to get series of novel 6-(substituted)-3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b]thiadiazole (TT1-TT11) The title compounds were characterized on the basis of IR, 1H NMR, 13C NMR and Mass spectral (MS) studies. Further they were evaluated for antibacterial and antifungal by Agar diffusion assay method, antitubercular activity by Micro-plate Alamar Blue Assay (MABA). Among eleven synthesized novel compounds TT2, TT3, TT10, a

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