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Journal articles on the topic 'Tribal bond'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Russo, Marianne Robin, Valerie C. Bryan, and Gerri Penney. "Emergency Preparedness." International Journal of Adult Vocational Education and Technology 3, no. 2 (2012): 23–34. http://dx.doi.org/10.4018/javet.2012040103.

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Since 9-11, emergency preparedness has been the focus on federal, state, tribal, and local levels. Although current research describes emergency management response, many barriers may exist that effect response systems, including the role of first responders, social vulnerability, and the way technology interfaces with these variables. Several factors determine the success of emergency preparedness and its ultimate impact on the health and safety of the community, including social media response, Community Response Grid (CRG) and social networks for older adults, emergency Internet and Communi

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Lavee, Moshe. "Marital Bond and Genealogical Anxiety – Reaffirming the Schism between Rabbinic Texts from Babylonia and the Land of Israel." Journal of Ancient Judaism 11, no. 1 (2020): 116–47. http://dx.doi.org/10.30965/21967954-12340006.

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Abstract Societies are constituted of thick networks of intersecting constructs: genealogical anxiety is bound up with stronger patriarchal family structures. Goody and Guichard portrayed two clusters of social features – the “Occidental” (bi-lineal family model, strengthened nuclear family, solid husband-wife relationship, monogamy, loose gender separation, and a higher status of women); and the “Oriental” (patrilineal model, broader family structure, weak husband-wife relationship, tribal importance attributed to genealogy, codes of honor and shame, legitimacy of polygamy, rigid gender separ

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Ali, Ghulam, Muhammad Ilyas Ansari, and Malik Firdous. "FATA Merger to Khyber Pakhtunkhwa: Problems and Prospects for Federalism in Pakistan." Global Political Review V, no. I (2020): 224–33. http://dx.doi.org/10.31703/gpr.2020(v-i).25.

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Federalism provides opportunity to the diverse societies with the distinct cultural and geographical heritage of such constitutional arrangements that they can strengthen their bond with the rest of the areas of a state. Federalism in Pakistan started in a unique way where its two main regions had no geographical adhesion. The west wing of Pakistan is culturally diverse. People of FATA lived their lives almost for seventy (70) years without constitutional rights. That was the reason after the American invasion in Afghanistan, Federally Administered Tribal Areas (FATA) became the hub of terrori

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A.K, Mohan, and Gangotri Dash. "PERCEPTION OF YOUTH ON MARRIAGE PRACTICES: A STUDY IN DODDA BIRANA KUPPE GRAM PANCHAYAT, H D KOTE TALUK, MYSURU DISTRICT." International Journal of Research -GRANTHAALAYAH 4, no. 3 (2016): 42–52. http://dx.doi.org/10.29121/granthaalayah.v4.i3.2016.2785.

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Marital relationship not only provides sanction to family life but also affects the life decisions and satisfaction of people in this bond. The ritual associated with marriage has direct impact on wellbeing of persons in this relationship. Although debates and discussions on child marriage and restrictions for widow etc. have brought legislations to prohibit such practices but still these are not completely eradicated. Hence, to make future free from such evils and to understand the marital satisfaction, it is essential to understand the perception of young people on the marriage rituals of th

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Fidiana, Fidiana. "KEPATUHAN PAJAK DALAM PERSPEKTIF NEO ASHABIYAH." EKUITAS (Jurnal Ekonomi dan Keuangan) 19, no. 2 (2017): 260. http://dx.doi.org/10.24034/j25485024.y2015.v19.i2.1768.

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The aim of this study is to analyze tax compliance behavior through “neo ashabiyah” perpective. The core of ashabiyah originally were a kind of bond of kinship, tribal ties, ethnic solidarity or social cohesion. Neo ashabiyah is developed since we founded that there were uncompliance behavior in fulfill tax obligation among taxpayers in the world. By neo ashabiyah, this study would explained how social cohesion mechanism take a look at efforts to avoid tax as collective consciousness that unified and tied exceeding their ethnic, interfaith, cultural, and country barriers. The merge of these aw

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Aarab Terrisse, Safae, Chris C. Parker, Karamouza Eleni, et al. "A meta-analysis on individual data of bone-targeting radio-isotopes in men with bone metastases from castration-resistant prostate cancer." Journal of Clinical Oncology 36, no. 6_suppl (2018): 352. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.352.

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352 Background: Among bone-targeted radio-isotopes (RI), Radium-223 (an α-emitter) is the only one with clearly demonstrated overall survival (OS) benefit in men with castration-resistant prostate cancer (CRPC). The aim of this meta-analysis is to estimate the OS impact of RI in men with CRPC. Methods: An individual patient data meta-analysis was carried out from randomized trials with inclusion period 1993-2013. Eligible trials included more than 50 patients, mandated bone metastases from CRPC and randomly evaluated RI. Endpoints were OS (primary), symptomatic skeletal events (SSE) and toxici

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Tion, M. A., and P. C. Njoku. "Assessing calcium availability from limestone sources through bone and blood status of chickens." Nigerian Journal of Animal Production 36, no. 1 (2021): 85–95. http://dx.doi.org/10.51791/njap.v36i1.1396.

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Calcium (Cu) availability from limestone (procured from different cement factories) was assessed through bone and blood status of chickens using the completely randomized design. Five hundred and twenty five (525) straight run broiler chicks that were 28 days Of age (trial l), four hundred and twenty (420) broiler finishers that were 56 days of age (trial 2), and 210 layers that had been laying for six months (trial 3) were used in the study. Six limestone dietary treatments and a control accounted for the seven diets that were assessed Twelve birds per treatment and 4 per replicate that had t

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Brinkhuis, Manje A. B., Árni Kristjánsson, Ben M. Harvey, and Jan W. Brascamp. "Temporal Characteristics of Priming of Attention Shifts Are Mirrored by BOLD Response Patterns in the Frontoparietal Attention Network." Cerebral Cortex 30, no. 4 (2019): 2267–80. http://dx.doi.org/10.1093/cercor/bhz238.

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Abstract Priming of attention shifts involves the reduction in search RTs that occurs when target location or target features repeat. We used functional magnetic resonance imaging to investigate the neural basis of such attentional priming, specifically focusing on its temporal characteristics over trial sequences. We first replicated earlier findings by showing that repetition of target color and of target location from the immediately preceding trial both result in reduced blood oxygen level-dependent (BOLD) signals in a cortical network that encompasses occipital, parietal, and frontal cort

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Balyuk, I. A. "Corporate Bond Market: International Experience and Russian Practice." Finance: Theory and Practice 23, no. 2 (2019): 74–83. http://dx.doi.org/10.26794/2587-5671-2019-23-2-74-83.

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The corporate bond market development is integral to increase the resilience of the Russian economy to external shocks and to build a new growth model in terms of sanctions. The purpose of the article is to analyze the current state of the Russian corporate bond market and to develop proposals for accelerating its further development considering the international experience. The proposals are based on a study of the legal base for the functioning of the international bond market, as well as modern technologies and tools that have proven to be effective in practice. As part of a comparative ana

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Mistry, Pramod K., Joel Charrow, Timothy Cox, et al. "Long-Term Effects of Oral Eliglustat on Skeletal Manifestations of Gaucher Disease Type 1: Results from Four Completed Clinical Trials." Blood 132, Supplement 1 (2018): 2396. http://dx.doi.org/10.1182/blood-2018-99-117289.

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Abstract Background: In Gaucher disease type 1 (GD1), deficient lysosomal acid β-glucosidase activity leads to accumulation of glucosylceramide and formation of lipid-laden macrophages known as Gaucher cells. Patients experience a range of disease manifestations including anemia, thrombocytopenia, hepatosplenomegaly, and debilitating bone complications that impair quality of life. Hematologists are central to disease recognition and management. Most patients, even those without overt symptoms of bone involvement, have radiologic evidence of bone disease. Eliglustat, an oral substrate-reduction

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Faizah, Yuniar Laeli Nur. "Pengaruh Laverage Maturity dan Size Perusahaan Terhadap Yield Obligasi Dengan Peringkat Obligasi Sebagai Variabel Intervening." Journal of Economic, Management, Accounting and Technology 2, no. 1 (2019): 43–54. http://dx.doi.org/10.32500/jematech.v2i1.574.

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This study aims to get empirical evidence on the effect of leverage, maturity, and size of the company against the results with intervening variables. The population in this study is all companies listed in Indonesia Stock Exchange (BEI) during 2011-2015 which has bonds inperiod 2012-2016.These bonds were assessed by rating agents of PT. Pefindo. Testing is done by using the path analysis, to determine the effect of leverage, maturity, and size of the company to the bond rating. Second path is for leverage, maturity, size, and ranking of results. Sobel test to process the mediation / interveni

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Agrawal, Sundeep, Joyce Cheng, Vishal Bhatnagar, Bellinda King-Kallimanis, Richard Pazdur, and Paul Gustav Kluetz. "Timing of assessments for PRO measures in advanced RCC clinical trials." Journal of Clinical Oncology 38, no. 15_suppl (2020): e19101-e19101. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e19101.

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e19101 Background: Efficient and thoughtful collection of PROs in randomized cancer trials is necessary, especially when comparing drugs with differing administration schedules. Assessment timing for PROs can dramatically influence results. We sought to better understand how different assessment schedules affect interpretation of toxicity using PRO data. Methods: We reviewed 3 randomized trials in advanced/metastatic RCC with a control arm of sunitinib administered 4 weeks on/2 weeks off. All 3 trials used FACT Kidney Symptom Index (FKSI-19 or -DRS) and one also used EORTC QLQ-C30. For each tr

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Brouns, Anita, Safiye Dursun, Gerben Bootsma, Anne-Marie C. Dingemans, and Lizza Hendriks. "Reporting of Incidence and Outcome of Bone Metastases in Clinical Trials Enrolling Patients with Epidermal Growth Factor Receptor Mutated Lung Adenocarcinoma—A Systematic Review." Cancers 13, no. 13 (2021): 3144. http://dx.doi.org/10.3390/cancers13133144.

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Bone metastases, occurring in 30–60% of patients with non-small cell lung cancer (NSCLC), are associated with decreased survival, cancer-induced bone pain, and skeletal-related events (SREs). Those with an activating epidermal growth factor mutation (EGFR+) seem to be more prone to develop bone metastases. To gain more insight into bone metastases-related outcomes in EGFR+ NSCLC, we performed a systematic review on Pubmed (2006–2021). Main inclusion criteria: prospective, phase II/III trials evaluating EGFR-tyrosine kinase inhibitors, ≥10 EGFR+ patients included, data on bone metastases and/or

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Mohamed, Huda Hamed Basher, Asma M. Serag Eldien, and Amr Zahran. "Augmentation versus No Augmentation for Immediate Postextraction Implants." International Journal of Dentistry 2018 (October 16, 2018): 1–10. http://dx.doi.org/10.1155/2018/5209108.

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Purpose. To assess the effects of augmentation versus no augmentation in patients restored with immediate postextraction single-tooth implants on implant failure and patient satisfaction. Materials and methods. We searched the Cochrane Oral Health Group Trial Register, Cochrane Central Register of Controlled Trials, MEDLINE, and the WHO International Clinical Trial Registry Platform (22 March 2017). Two reviewers independently assessed trials for inclusion and risk of bias, extracted data, and checked for accuracy. We have expressed results as risk ratio or mean differences, together with thei

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De la Torre Canales, Giancarlo, Natalia Alvarez-Pinzon, Victor Ricardo Manuel Muñoz-Lora, et al. "Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial." Toxins 12, no. 6 (2020): 395. http://dx.doi.org/10.3390/toxins12060395.

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This study assessed the safety and efficacy of three different doses of BoNT-A for persistent myofascial pain (MFP). One hundred female subjects were randomly assigned into five groups (n = 20): oral appliance (OA), saline solution (SS) and three BoNT-A groups with different doses. Pain intensity and pressure pain threshold were evaluated up to 24 weeks after treatment. Adverse effects related to muscle contraction, masticatory performance, muscle thickness and mandibular bone volume were also assessed. Changes over time were compared within and between groups. The “nparLD” package and Wilcoxo

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Rogers, Robert S., Andrew W. Dawson, Ze Wang, John P. Thyfault, and Pamela S. Hinton. "Acute response of plasma markers of bone turnover to a single bout of resistance training or plyometrics." Journal of Applied Physiology 111, no. 5 (2011): 1353–60. http://dx.doi.org/10.1152/japplphysiol.00333.2011.

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The time course of changes in plasma bone turnover markers following an acute bout of resistance training (RT) or plyometrics (PLY) has not been well characterized. This study is the first to compare the acute response of bone formation and resorption markers to a single bout of RT or PLY. Using a partially randomized, cross-over study design, 12 recreationally active men, aged 43 ± 5 yr, each completed four exercise trials: RT (Fed/Fasted) and PLY (Fed/Fasted). In addition to the RT and PLY trials, 5 of the original 12 participants also completed a fasted, no-exercise control trial to examine

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Park, Julie R., Rochelle Bagatell, Susan L. Cohn, et al. "Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting." Journal of Clinical Oncology 35, no. 22 (2017): 2580–87. http://dx.doi.org/10.1200/jco.2016.72.0177.

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Purpose More than two decades ago, an international working group established the International Neuroblastoma Response Criteria (INRC) to assess treatment response in children with neuroblastoma. However, this system requires modification to incorporate modern imaging techniques and new methods for quantifying bone marrow disease that were not previously widely available. The National Cancer Institute sponsored a clinical trials planning meeting in 2012 to update and refine response criteria for patients with neuroblastoma. Methods Multidisciplinary investigators from 13 countries reviewed dat

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Rachner, Tilman D., Lorenz C. Hofbauer, Andy Göbel, and Elena Tsourdi. "Novel therapies in osteoporosis: PTH-related peptide analogs and inhibitors of sclerostin." Journal of Molecular Endocrinology 62, no. 2 (2019): R145—R154. http://dx.doi.org/10.1530/jme-18-0173.

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Bone-forming approaches to treat patients with severe osteoporosis are effective, but treatment options are limited, and there is an unmet clinical need for additional drugs. This review discusses two novel and advanced anabolic therapeutic concepts that have successfully completed phase 3 trials. Romosozumab is a monoclonal antibody that targets the Wnt inhibitor sclerostin. Two phase 3 trials (FRAME and ARCH) of romosozumab for the treatment of postmenopausal osteoporosis have been completed. Both trials successfully reached their primary endpoint by reducing vertebral fractures by 75% compa

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Ruge, Hannes, Thomas Goschke, and Todd S. Braver. "Separating event-related BOLD components within trials: The partial-trial design revisited." NeuroImage 47, no. 2 (2009): 501–13. http://dx.doi.org/10.1016/j.neuroimage.2009.04.075.

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Gurses, Gokhan, and Alparslan Esen. "Evaluation of Two Different Biomaterials Effect on Immediate Implant Stability and Bone Changes, a Randomized Parallel Group Clinical Trial." International Journal of Science and Research (IJSR) 8, no. 9 (2019): 346–50. http://dx.doi.org/10.21275/art20201028.

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Hodgkinson, Alison J., Olivia A. M. Wallace, Marlena C. Kruger, and Colin G. Prosser. "Effect of the dietary delivery matrix on vitamin D3 bioavailability and bone mineralisation in vitamin-D3-deficient growing male rats." British Journal of Nutrition 119, no. 2 (2017): 143–52. http://dx.doi.org/10.1017/s0007114517003518.

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AbstractThis study assessed bioavailability and utilisation of vitamin D3 in two feeding trials using young, growing Sprague–Dawley male rats. Trial one fed animals standard AIN-93G diet (casein protein) containing no vitamin D3 and goat or cow skimmed milk supplemented with vitamin D3. Trial two fed animals modified dairy-free AIN-93G diet (egg albumin) containing no vitamin D3 and goat or cow skimmed or full-fat milk supplemented with vitamin D3. Control groups received AIN-93G diets with or without vitamin D, and water. At 8 weeks of age, blood samples were collected for vitamin and mineral

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Lebensburger, Jeffrey D., Lauren Pair, Lee Hilliard, and Thomas H. Howard. "A Systematic Review Of All Interventional Sickle Cell Trials Registered At Clinicaltrials.Gov." Blood 122, no. 21 (2013): 2990. http://dx.doi.org/10.1182/blood.v122.21.2990.2990.

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Abstract Background Clinicaltrials.gov was created in 2000 to comply with the FDA Modernization Act of 1997 and since 2007, Federal law (Section 801 of the FDA Amendments Acts) mandates registration of all applicable, prospective clinical drug trials of health outcomes. ICMJE journals also require registration of all intervention trials prior to publication. Clinicaltrials.gov offers patients and clinicians a valuable tool to identify open sickle cell disease (SCD) clinical trials by disease and results of closed trials with links to manuscripts. Objective To conduct a systematic review of all

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Petersen, Lars J., Martin N. Johansen, Jesper Strandberg, Louise Stenholt, and Helle D. Zacho. "Reporting and handling of equivocal imaging findings in diagnostic studies of bone metastasis in prostate cancer." Acta Radiologica 61, no. 8 (2019): 1096–104. http://dx.doi.org/10.1177/0284185119890087.

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Background Equivocal scanning results occur. It remains unclear how these results are presented and their management influence diagnostic characteristics. Purpose To investigate the reporting and handling of equivocal imaging findings in diagnostic studies of bone metastases, and to assess the impact on diagnostic performance of the methods used to analyze equivocal findings. The conceptual issue was reified based on two actual observations. Material and Methods A recent meta-analysis of bone metastases in prostate cancer was conducted and data were obtained from a large clinical trial with a

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LEESON, S., J. D. SUMMERS, and R. J. JULIAN. "INFLUENCE OF PRELAY AND EARLY-LAY DIETARY CALCIUM CONCENTRATION ON PERFORMANCE AND BONE INTEGRITY OF LEGHORN PULLETS." Canadian Journal of Animal Science 66, no. 4 (1986): 1087–95. http://dx.doi.org/10.4141/cjas86-119.

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Two trials were conducted to note the pullets' response to diet concentrations of calcium from 0.9 to 3.5% fed from 19 wk to day of producing their 4th egg. After this time all birds were fed a common 3.5% Ca layer diet. In Trials 1 and 2 each diet treatment (0.9, 1.5, 2.0, 2.5, 3.0 or 3.5% Ca) was tested with 5 and 16 individually caged birds, respectively. Results from Trial 1 indicated a small (P > 0.05) increase in calcium retention in response to increased diet calcium. Diet calcium concentration had no effect on age at 1st egg, although use of 3.5% Ca during this time resulted in a re

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Buckley, C. J., S. Downes, N. Khaleque, S. J. Bellamy, and X. Zhang. "Mapping the density and mineral phase of calcium in bone at the interface with biomaterials using scanning x-ray microscopy." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 44–45. http://dx.doi.org/10.1017/s0424820100167950.

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Orthopaedic surgery often involves the insertion of a prosthetic implant. For successful and rapid healing, it is important for the prosthesis to make a close and well integrated bond with the bone tissue. To assist this integration, a number of “biomaterials” are on trial as components in the prosthetic implants. Much work is in progress to determine the phase, composition and density of bone mineral at the bone/biomaterial interface. It is expected that the results of this work can be used to develop synthetic calcium phosphates which can be incorporated in prosthetic implants. The compositi

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Alfadda, Sara A. "Current Evidence on Dental Implants Outcomes in Smokers and Nonsmokers: A Systematic Review and Meta-Analysis." Journal of Oral Implantology 44, no. 5 (2018): 390–99. http://dx.doi.org/10.1563/aaid-joi-d-17-00313.

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This systematic review aims to answer the following PICO (Participants, Intervention, Comparison, and Outcome) question: “Does smoking increase the rates of implant failure and peri-implant marginal bone loss in patients with dental implants?” An extensive electronic search of the Cochrane Central Register of Controlled Trials, PubMed, Medline, Embase, and Web of Science databases and a subsequent hand search were performed. Only randomized controlled trial, controlled clinical trials, and prospective studies published up to January 2017 were included. For dichotomous outcomes, the effect esti

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Šponer, Pavel, Stanislav Filip, Tomáš Kučera та ін. "Utilizing Autologous Multipotent Mesenchymal Stromal Cells andβ-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial". BioMed Research International 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/2076061.

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The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporousβ-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) orβ-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty. Both groups were assessed using the Harris Hip Score, radiography, and DEXA scanning at 6 weeks and 3, 6, and 12 months postoperatively. A significant difference in the bone defect healing was observed between both groups of patients (P<0.05

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Crump, M., P. E. Goss, M. Prince, and C. Girouard. "Outcome of extensive evaluation before adjuvant therapy in women with breast cancer and 10 or more positive axillary lymph nodes." Journal of Clinical Oncology 14, no. 1 (1996): 66–69. http://dx.doi.org/10.1200/jco.1996.14.1.66.

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PURPOSE To evaluate the effect of extensive screening of women with high-risk, node-positive breast cancer on the detection of occult metastatic disease and patient eligibility for a randomized trial of the addition of high-dose chemotherapy and autologous bone marrow support (ABMT) to standard adjuvant therapy. PATIENTS AND METHODS Women with resected T1-3N1,2 primary breast cancer and > or = 10 positive axillary lymph nodes referred for possible trial participation were evaluated for this report. All had normal chest x-ray, bone scan, and liver ultrasound performed by the referring physic

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Kushmanova, Laylo. "Modern Tendencies In The Ethnic Relations Of Kuramas." American Journal of Interdisciplinary Innovations and Research 02, no. 12 (2020): 17–21. http://dx.doi.org/10.37547/tajiir/volume02issue12-03.

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The article highlights the issues, such as Kurama ethnicity ( or “ethnic group of Kuramas”), which is involved in the Uzbek nation, its ethnic composition, the identity sense of the Kuramas in terms of unity of the people, the attitude to the Uzbek national unity and transformational processes. Corresponding issues are presented as material for ongoing scientific analysis based on field materials and, where appropriate, scientific and popular literature data. The core meaning of the term “kurama” is explined by the fact that this ethnic group is of the polycomponent. To be specific, it is feas

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Kamaluddin, Agus. "Chemo-entrepreneurship Modelling on Chemical Bonding Materials as an Effort to Grow Entrepreneurial Spirit of Students with Hearing Impairment in (Islamic) Senior High School." International Journal of Chemistry Education Research 2, no. 1 (2018): 34–44. http://dx.doi.org/10.20885/ijcer.v2i1.10085.

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ABSTRACT: This research aims to develop MEc Bond learning media (Magnetic Educhem Bonding) for students with hearing impairment in (Islamic) senior high school based on chemo-entrepreneurship modeling. This research uses the development model by Borg & Gall that includes the identification of potentials and problems, product selection, literature review, planning, developing initial product draft, initial field trials and product revisions, and it ends with major field trials and product revision. The subjects of this research include material experts, media experts, disability experts, se

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Kamaluddin, Agus. "Chemo-entrepreneurship Modelling on Chemical Bonding Materials as an Effort to Grow Entrepreneurial Spirit of Students with Hearing Impairment in (Islamic) Senior High School." International Journal of Chemistry Education Research 2, no. 1 (2018): 34–44. http://dx.doi.org/10.20885/ijcer.vol2.iss1.art6.

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ABSTRACT: This research aims to develop MEc Bond learning media (Magnetic Educhem Bonding) for students with hearing impairment in (Islamic) senior high school based on chemo-entrepreneurship modeling. This research uses the development model by Borg & Gall that includes the identification of potentials and problems, product selection, literature review, planning, developing initial product draft, initial field trials and product revisions, and it ends with major field trials and product revision. The subjects of this research include material experts, media experts, disability experts, se

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Liu, Wei, Chenhui Yao, Qian Shang, Yuqiang Liu, Changying Liu, and Fancui Meng. "Insights into the binding of dorzagliatin with glucokinase: A molecular dynamics simulation." Journal of Theoretical and Computational Chemistry 19, no. 07 (2020): 2050027. http://dx.doi.org/10.1142/s0219633620500273.

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Human glucokinase (GK) is a potentially attractive target for diabetes, playing a prominent role in the control of glucose homeostasis. Dorzagliatin is the first GK activator (GKA) to enter phase III clinical trial. In this study, the possible binding mode of dorzagliatin with GK was investigated via the molecular simulation method. Two other systems in the absence of dorzagliatin and glucose were also studied to disclose the roles of dorzagliatin and glucose. The outcomes revealed that dorzagliatin can create the characteristic hydrogen bonds of GKA with Arg63, and Arg63 can form hydrogen bon

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Cosman, Felicia. "ANABOLIC THERAPY AND OPTIMAL TREATMENT SEQUENCES FOR PATIENTS WITH OSTEOPOROSIS AT HIGH RISK FOR FRACTURE." Endocrine Practice 26, no. 7 (2020): 777–86. http://dx.doi.org/10.4158/ep-2019-0596.

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Objective: Provide an update regarding anabolic medications for osteoporosis, which are often considered to be the last resort for patients with osteoporosis, after multiple fractures have already occurred and other medications have already been administered. Methods: Literature review and discussion. Results: Recent pivotal trial data for anabolic agents and randomized trials comparing anabolic and antiresorptive medications suggest that three anabolic agents (teriparatide, abaloparatide, and romosozumab) reduce nonvertebral and vertebral fractures faster and to a greater extent than potent a

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Tunik, Eugene, Paul J. Schmitt, and Scott T. Grafton. "BOLD Coherence Reveals Segregated Functional Neural Interactions When Adapting to Distinct Torque Perturbations." Journal of Neurophysiology 97, no. 3 (2007): 2107–20. http://dx.doi.org/10.1152/jn.00405.2006.

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In the natural world, we experience and adapt to multiple extrinsic perturbations. This poses a challenge to neural circuits in discriminating between different context-appropriate responses. Using event-related fMRI, we characterized the neural dynamics involved in this process by randomly delivering a position- or velocity-dependent torque perturbation to subjects’ arms during a target-capture task. Each perturbation was color-cued during movement preparation to provide contextual information. Although trajectories differed between perturbations, subjects significantly reduced error under bo

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Swerdloff, Ronald S., and Robert E. Dudley. "A new oral testosterone undecanoate therapy comes of age for the treatment of hypogonadal men." Therapeutic Advances in Urology 12 (January 2020): 175628722093723. http://dx.doi.org/10.1177/1756287220937232.

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Background: A novel formulation of oral testosterone undecanoate (TU) was studied in a long- and short-term phase III trial to evaluate safety and efficacy. Methods: Hypogonadal men (age 18–65 years; two morning serum testosterone (T) <300 ng/dl with signs/symptoms) were recruited into a 365 day (trial I) or 105 day (trial II), randomized, multicenter trial. Patients were randomized 1:1 to oral TU ( n = 161) or T-gel ( n = 160) in trial I, and 3:1 to oral TU, twice daily (BID) JATENZO® ( n = 166) or a topical T product [Axiron® ( n = 56)] in trial II. Dose adjustments were based on average

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Perera, Nirosha D., Tiffany R. Bellomo, Henry K. Litt, et al. "Female participation in U.S. oncology clinical trials registered on ClinicalTrials.gov from 2008 to 2020." Journal of Clinical Oncology 39, no. 28_suppl (2021): 85. http://dx.doi.org/10.1200/jco.2020.39.28_suppl.85.

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85 Background: Females are thought to be underrepresented in clinical trials, which may lead to care disparities. We characterized female enrollment trends in U.S. oncology trials registered on ClinicalTrials.gov and identified features associated with accurate representation. Methods: We employed a cross-sectional study design with descriptive, logistic regression, and cox regression analyses. We downloaded 270,172 studies registered on the Aggregate Analysis of the ClinicalTrials.gov database from October 1, 2008 to March 9, 2020, excluding non-interventional and reproductive organ specific

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Hagino, Hiroshi. "Vitamin D3 analogs for the treatment of osteoporosis." Canadian Journal of Physiology and Pharmacology 93, no. 5 (2015): 327–32. http://dx.doi.org/10.1139/cjpp-2014-0419.

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Vitamin D supplementation is recommended whenever patients are given therapeutic drugs for osteoporosis, to make their calcium (Ca) balance positive. Vitamin D is converted to 25-hydroxyvitamin D in the liver, and then activated to become 1α,25-dihydroxyvitamin D in the kidneys. The active vitamin D acts in the intestine to stimulate Ca absorption and maintain the Ca balance. 2β-(3-Hydroxypropyloxy)-1α,25-dihydroxyvitamin D3 (eldecalcitol) and 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) are newly developed vitamin D analogs, with a substitution at the 2 position of 1α,25-dihydroxy

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Halabi, Susan, Akash Roy, Qian Yang, Wanling Xie, William Kevin Kelly, and Christopher Sweeney. "Radiographic progression-free survival as a surrogate endpoint of overall survival in men with metastatic castrate-resistant prostate cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 5057. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.5057.

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5057 Background: Radiographic progression-free survival (rPFS) is commonly used as a co-primary endpoint in randomized clinical trials in men with metastatic castrate-resistant prostate cancer (mCRPC). However, rPFS has not been established as a valid surrogate endpoint of overall survival (OS) in men with mCRPC. Here, we hypothesized that rPFS is a reliable surrogate for OS in mCRPC. We also explored whether PFS is a valid surrogate endpoint of OS at the aggregate trial level. Methods: We performed a systematic search of the literature encompassing the period January 2004-December 2020 using

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Pierce, Jordan E., and Jennifer E. McDowell. "Modulation of cognitive control levels via manipulation of saccade trial-type probability assessed with event-related BOLD fMRI." Journal of Neurophysiology 115, no. 2 (2016): 763–72. http://dx.doi.org/10.1152/jn.00776.2015.

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Cognitive control supports flexible behavior adapted to meet current goals and can be modeled through investigation of saccade tasks with varying cognitive demands. Basic prosaccades (rapid glances toward a newly appearing stimulus) are supported by neural circuitry, including occipital and posterior parietal cortex, frontal and supplementary eye fields, and basal ganglia. These trials can be contrasted with complex antisaccades (glances toward the mirror image location of a stimulus), which are characterized by greater functional magnetic resonance imaging (MRI) blood oxygenation level-depend

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Armstrong, Andrew J., Reza Kaboteh, Michael Anthony Carducci, et al. "Association of bone scan index (BSI) with prognostic biomarkers and survival in men with metastatic castration-resistant prostate cancer (mCRPC) enrolled in a prospective randomized controlled trial of tasquinimod." Journal of Clinical Oncology 31, no. 15_suppl (2013): 5081. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5081.

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5081 Background: Tasquinimod (T) is an oral immunomodulatory and anti-angiogenic agent currently in phase 3 testing in mCRPC. In a randomized, double-blind phase 2 multicenter study, 201 men with mCRPC who received T had improved radiographic PFS vs. placebo (P), with a more pronounced effect seen in men with bone metastases. Given the subjectivity/variability of bone scan measurements, we sought to evaluate the bone scan index (BSI), a quantitative and objective measure of BS activity, over time in this controlled clinical trial. Post-treatment BSI changes were examined given their prior asso

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Weil, R. S., N. Furl, C. C. Ruff, et al. "Rewarding Feedback After Correct Visual Discriminations Has Both General and Specific Influences on Visual Cortex." Journal of Neurophysiology 104, no. 3 (2010): 1746–57. http://dx.doi.org/10.1152/jn.00870.2009.

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Reward can influence visual performance, but the neural basis of this effect remains poorly understood. Here we used functional magnetic resonance imaging to investigate how rewarding feedback affected activity in distinct areas of human visual cortex, separating rewarding feedback events after correct performance from preceding visual events. Participants discriminated oriented gratings in either hemifield, receiving auditory feedback at trial end that signaled financial reward after correct performance. Greater rewards improved performance for all but the most difficult trials. Rewarding fee

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Al-Rudayni, Ali Hatem Manfi, Divya Gopinath, Mari Kannan Maharajan, Sajesh Kalkandi Veettil, and Rohit Kunnath Menon. "Efficacy of Oral Cryotherapy in the Prevention of Oral Mucositis Associated with Cancer Chemotherapy: Systematic Review with Meta-Analysis and Trial Sequential Analysis." Current Oncology 28, no. 4 (2021): 2852–67. http://dx.doi.org/10.3390/curroncol28040250.

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Background: This review aimed to evaluate the efficacy of oral cryotherapy in the prevention of chemotherapy-induced oral mucositis using meta-analysis and trial sequential analysis, as well as to assess the quality of the results by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Methods: A comprehensive search of three databases including Medline, Embase and Central was performed to identify randomized controlled trials that used oral cryotherapy for the prevention of chemotherapy-induced oral mucositis. The primary outcome was the incidence of oral m

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Ning, Yangmin M., Clara Chen, Virginia Ellen Maher, James Xunhai Xu, Geoffrey Kim, and Richard Pazdur. "Tumor progression versus bone scan “flare” in new lesions detected on early bone scans in patients with chemo-naïve metastatic castration resistant prostate cancer (mCRPC) treated with placebo or enzalutamide." Journal of Clinical Oncology 34, no. 2_suppl (2016): 305. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.305.

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305 Background: To differentiate between bone metastasis progression vs. Tc99m scan “flare” in new lesions on early bone scans ( ≤ 12 wks), ≥ 2 additional lesions on a confirmatory scan (6 wks later) are proposed. This reduces the risk of misreading scan “flare” as progression in responding patients (pts). Independent central review (ICR) of scans from placebo (PLC)-controlled trials can help evaluate the role of confirmatory scans as PLC should neither delay progression nor elicit scan “flare”. Methods: The ICR datasets from a randomized PLC-controlled trial of enzalutamide (ENZ) in pts with

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van den Boom, Noortje Anna Clasina, Marinus Winters, Hidde Jacobs Haisma, and Maarten Hendrik Moen. "Efficacy of Stem Cell Therapy for Tendon Disorders: A Systematic Review." Orthopaedic Journal of Sports Medicine 8, no. 4 (2020): 232596712091585. http://dx.doi.org/10.1177/2325967120915857.

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Background: Stem cell therapy is an emerging treatment for tendon disorders. Purpose: To systematically review the efficacy of stem cell therapy for patients with tendon disorders. Study Design: Systematic review; Level of evidence, 4. Methods: MEDLINE/PubMed, EMBASE, CINAHL, CENTRAL, PEDro, and SPORTDiscus; trial registers; and gray literature were searched to identify randomized controlled trials (RCTs) and non-RCTs, cohort studies, and case series with 5 or more cases. Studies investigating any type of stem cell therapy for patients with tendon disorders were eligible if they included patie

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Faria, Henrique Gonsales de, Maria Cristina Thomaz, Urbano Dos Santos Ruiz, et al. "Effects of phytase on pig diets digestibilities, bone mineral deposition, performance and manure production." Semina: Ciências Agrárias 36, no. 6Supl2 (2015): 4519. http://dx.doi.org/10.5433/1679-0359.2015v36n6sup2p4519.

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Two trials were conducted to evaluate phytase addition to diets with corn, rice and soybean meals for swine. In the first trial, the digestibilities of gross energy and crude protein and the availabilities of calcium (Ca) and phosphorous (P) of diets with or without phytase were evaluated in growing barrows (BW 20.42 ± 2.45 kg), using the total feces and feed collection methods. In the second trial, the parameters evaluated were pig performance, mineral contents in the 3rd and 4th metacarpals, feces production and composition of growing and finishing gilts fed one of the following diets: Posit

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Bloomfield, D. J. "Should bisphosphonates be part of the standard therapy of patients with multiple myeloma or bone metastases from other cancers? An evidence-based review." Journal of Clinical Oncology 16, no. 3 (1998): 1218–25. http://dx.doi.org/10.1200/jco.1998.16.3.1218.

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PURPOSE To review objectively the evidence for the use of bisphosphonates for the reduction of skeletal events or the management of pain due to multiple myeloma or bone metastases from other types of cancer. METHODS MEDLINE was searched from 1976 onwards using the MeSH terms "exp diphosphonates/," "exp bone neoplasms/," "exp multiple myeloma/," and "bone metastases" as text words. Bibliographies of reports on these topics and major medical and scientific journals were searched. Experts in the field were approached. The question was defined and the evidence stratified in a hierarchical manner a

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Realpe, Alba X., James Blackstone, Damian R. Griffin, et al. "Barriers to recruitment to an orthopaedic randomized controlled trial comparing two surgical procedures for ankle arthritis." Bone & Joint Open 2, no. 8 (2021): 631–37. http://dx.doi.org/10.1302/2633-1462.28.bjo-2021-0074.r1.

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Aims A multicentre, randomized, clinician-led, pragmatic, parallel-group orthopaedic trial of two surgical procedures was set up to obtain high-quality evidence of effectiveness. However, the trial faced recruitment challenges and struggled to maintain recruitment rates over 30%, although this is not unusual for surgical trials. We conducted a qualitative study with the aim of gathering information about recruitment practices to identify barriers to patient consent and participation to an orthopaedic trial. Methods We collected 11 audio recordings of recruitment appointments and interviews of

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Faria, Henrique Gonsales de, Maria Cristina Thomaz, Urbano Dos Santos Ruiz, et al. "Effects of phytase on pig diets digestibilities, bone mineral deposition, performance and manure production." Semina: Ciências Agrárias 36, no. 6Supl2 (2015): 4519. http://dx.doi.org/10.5433/1679-0359.2015v36n6supl2p4519.

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<p>Two trials were conducted to evaluate phytase addition to diets with corn, rice and soybean meals for swine. In the first trial, the digestibilities of gross energy and crude protein and the availabilities of calcium (Ca) and phosphorous (P) of diets with or without phytase were evaluated in growing barrows (BW 20.42 ± 2.45 kg), using the total feces and feed collection methods. In the second trial, the parameters evaluated were pig performance, mineral contents in the 3rd and 4th metacarpals, feces production and composition of growing and finishing gilts fed one of the following die

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Kouvelioti, R., N. Kurgan, B. Falk, W. E. Ward, A. R. Josse, and P. Klentrou. "Response of Sclerostin and Bone Turnover Markers to High Intensity Interval Exercise in Young Women: Does Impact Matter?" BioMed Research International 2018 (November 1, 2018): 1–8. http://dx.doi.org/10.1155/2018/4864952.

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This study examined potential exercise-induced changes in sclerostin and in bone turnover markers in young women following two modes of high intensity interval exercise that involve impact (running) or no-impact (cycling). Healthy, recreationally active, females (n=20; 22.5±2.7 years) performed two exercise trials in random order: high intensity interval running (HIIR) on a treadmill and high intensity interval cycling (HIIC) on a cycle ergometer. Trials consisted of eight 1 min running or cycling intervals at ≥90% of maximal heart rate, separated by 1 min passive recovery intervals. Blood sam

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Marson, Ben A., Simon Craxford, Sandeep R. Deshmukh, Douglas Grindlay, Joseph Manning, and Benjamin J. Ollivere. "Outcomes reported in trials of childhood fractures." Bone & Joint Open 1, no. 5 (2020): 167–74. http://dx.doi.org/10.1302/2046-3758.15.bjo-2020-0031.

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Aims To analyze outcomes reported in trials of childhood fractures. Methods OVID MEDLINE, Embase, and Cochrane CENTRAL databases were searched on the eighth August 2019. A manual search of trial registries, bibliographic review and internet search was used to identify additional studies. 11,476 studies were screened following PRISMA guidelines. 100 trials were included in the analysis. Data extraction was completed by two researchers for each trial. Study quality was not evaluated. Outcomes reported by trials were mapped onto domains in the World Health Organization (WHO) International Classif

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