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1

Kuzmin, V. A., T. A. Podrugina, T. D. Nekipelova, I. A. Doroshenko, M. V. Proskurnina, G. V. Golovina, E. V. Radchenko, et al. "New phosphonate-substituted tricarbocyanines and their interaction with bovine serum albumin." Doklady Chemistry 470, no. 1 (September 2016): 264–67. http://dx.doi.org/10.1134/s001250081609007x.

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Podrugina, T. A., A. S. Pavlova, I. A. Doroshenko, V. A. Kuz’min, A. A. Kostyukov, and A. A. Shtil’. "Synthesis and photophysical properties of conformationally fixed tricarbocyanines with phosphonate groups." Russian Chemical Bulletin 67, no. 5 (May 2018): 806–14. http://dx.doi.org/10.1007/s11172-018-2141-4.

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Podrugina, T. A., V. V. Temnov, I. A. Doroshenko, V. A. Kuzmin, T. D. Nekipelova, M. V. Proskurnina, and N. S. Zefirov. "Synthesis of advanced fluorescent probes — water-soluble symmetrical tricarbocyanines with phosphonate groups." Russian Chemical Bulletin 65, no. 11 (November 2016): 2722–28. http://dx.doi.org/10.1007/s11172-016-1642-2.

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4

Guo, Zhiqian, Weihong Zhu, Mingming Zhu, Xumeng Wu, and He Tian. "Near-Infrared Cell-Permeable Hg2+-Selective Ratiometric Fluorescent Chemodosimeters and Fast Indicator Paper for MeHg+ Based on Tricarbocyanines." Chemistry - A European Journal 16, no. 48 (October 29, 2010): 14424–32. http://dx.doi.org/10.1002/chem.201001769.

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5

Mellanby, Richard J., Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, and Marc Vendrell. "Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo." Chemical Science 9, no. 36 (2018): 7261–70. http://dx.doi.org/10.1039/c8sc00900g.

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6

Toum Terrones, Yamili, Federico Coluccio Leskow, Andrea V. Bordoni, Sofía L. Acebedo, Carla C. Spagnuolo, and Alejandro Wolosiuk. "A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells." Journal of Materials Chemistry B 5, no. 22 (2017): 4031–34. http://dx.doi.org/10.1039/c7tb00622e.

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7

Samaniego Lopez, Cecilia, María Amparo Lago Huvelle, María Laura Uhrig, Federico Coluccio Leskow, and Carla C. Spagnuolo. "Recognition of saccharides in the NIR region with a novel fluorogenic boronolectin: in vitro and live cell labeling." Chemical Communications 51, no. 23 (2015): 4895–98. http://dx.doi.org/10.1039/c4cc10425k.

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8

Takechi, Kensuke, P. K. Sudeep, and Prashant V. Kamat. "Harvesting Infrared Photons with Tricarbocyanine Dye Clusters." Journal of Physical Chemistry B 110, no. 33 (August 2006): 16169–73. http://dx.doi.org/10.1021/jp063651b.

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9

Richter, Walter. "Hochaufgelöstes ESR-Spektrum des 3,3′-Di(ethylbenzthia)tricarbocyanins." Zeitschrift für Chemie 25, no. 6 (August 31, 2010): 223. http://dx.doi.org/10.1002/zfch.19850250609.

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10

Yan, Luomei, Hua Zhou, Cunqi Wu, Lidan Wang, Wei Yang, Manyu Jin, Yongxia Zhao, and Jingwei Xu. "A pH sensitive fluorescence probe based on tricarbocyanine." Chemical Research in Chinese Universities 32, no. 6 (November 23, 2016): 877–81. http://dx.doi.org/10.1007/s40242-016-6213-4.

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11

Ashworth, Stephen H., Andreas Kummrow, and Kurt Lenz. "Resonance Raman and optical dephasing study of tricarbocyanine dyes." Journal of Raman Spectroscopy 28, no. 7 (July 1997): 537–46. http://dx.doi.org/10.1002/(sici)1097-4555(199707)28:7<537::aid-jrs134>3.0.co;2-y.

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12

Tkachev, V. A., A. V. Tolmachev, L. V. Chernigov, and Yu L. Slominsky. "Structuring of tricarbocyanine dye molecules in Langmuir-Blodgett films." Russian Chemical Bulletin 44, no. 7 (July 1995): 1232–36. http://dx.doi.org/10.1007/bf00700894.

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13

Flanagan,, James H., Shaheer H. Khan, Steve Menchen, Steven A. Soper, and Robert P. Hammer. "Functionalized Tricarbocyanine Dyes as Near-Infrared Fluorescent Probes for Biomolecules." Bioconjugate Chemistry 8, no. 5 (September 1997): 751–56. http://dx.doi.org/10.1021/bc970113g.

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14

Kwon Lee, Sang, and Allen J. Bard. "Near-Ir Electrogenerated Chemiluminescence of Tricarbocyanine Dyes in Micellar Systems." Analytical Letters 31, no. 13 (October 1998): 2209–29. http://dx.doi.org/10.1080/00032719808005297.

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15

Kuzmin, Vladimir A., Tatiana D. Nekipelova, Tatyana A. Podrugina, Galina V. Golovina, Alexey A. Kostyukov, Viktor V. Temnov, Irina A. Doroshenko, Eugene V. Radchenko, Vladimir A. Palyulin, and Nikolay S. Zefirov. "Complex formation of albumin with tricarbocyanine dyes containing phosphonate groups." Photochemical & Photobiological Sciences 15, no. 11 (2016): 1377–84. http://dx.doi.org/10.1039/c6pp00246c.

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16

Perlitz, Christin, Kai Licha, Frank-Detlef Scholle, Bernd Ebert, Malte Bahner, Peter Hauff, Kurt Thomas Moesta, and Michael Schirner. "Comparison of Two Tricarbocyanine-Based Dyes for Fluorescence Optical Imaging." Journal of Fluorescence 15, no. 3 (May 2005): 443–54. http://dx.doi.org/10.1007/s10895-005-2636-x.

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17

Dimitriev, Oleg, Alexander Fedoryak, Yuri Slominskii, Anna Smirnova, and Tsukasa Yoshida. "Phonon-assisted anti-Stokes luminescence of tricarbocyanine near-infrared dye." Chemical Physics Letters 738 (January 2020): 136905. http://dx.doi.org/10.1016/j.cplett.2019.136905.

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18

Li, Chun-Yan, Xue-Fei Kong, Yong-Fei Li, Chun-Xiang Zou, Dan Liu, and Wei-Guo Zhu. "Ratiometric and colorimetric fluorescent chemosensor for Ag+ based on tricarbocyanine." Dyes and Pigments 99, no. 3 (December 2013): 903–7. http://dx.doi.org/10.1016/j.dyepig.2013.07.032.

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19

Benicewicz, P. K., J. P. Roberts, and A. J. Taylor. "The absorption characteristics and recovery dynamics of the tricarbocyanine dye DTP." Optics Communications 86, no. 5 (December 1991): 393–96. http://dx.doi.org/10.1016/0030-4018(91)90501-4.

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20

Menéndez, Guillermo O., Cecilia Samaniego López, Elizabeth A. Jares-Erijman, and Carla C. Spagnuolo. "A Versatile Near-Infrared Asymmetric Tricarbocyanine for Zinc Ion Sensing in Water." Photochemistry and Photobiology 89, no. 6 (September 23, 2013): 1354–61. http://dx.doi.org/10.1111/php.12160.

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21

Zhu, Ruixue, Rong Lü, and Anchi Yu. "Aggregation Behaviors of Tricarbocyanine Dye in Water and in AOT Reverse Micelles." Chinese Journal of Chemistry 29, no. 3 (March 2011): 405–10. http://dx.doi.org/10.1002/cjoc.201190095.

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22

Yang, Xiaojing, Liqiao Shen, Haibo Bao, Xinxiu Fang, Jingwei Xu, Yongxia Zhao, and Wei Yang. "A tricarbocyanine near-infrared fluorescent probe for sulfide through a copper displacement mechanism." Sensors and Actuators B: Chemical 220 (December 2015): 1361–67. http://dx.doi.org/10.1016/j.snb.2015.07.057.

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23

Davidson, Yolanda Y., Bonnie M. Gunn, and Steven A. Soper. "Spectroscopic and Binding Properties of Near-Infrared Tricarbocyanine Dyes to Double-Stranded DNA." Applied Spectroscopy 50, no. 2 (February 1996): 211–21. http://dx.doi.org/10.1366/0003702963906429.

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The noncovalent binding and spectroscopic properties of several near-infrared tricarbocyanine dyes with respect to sonicated calf-thymus DNA are reported. The dyes investigated were diethylthiatricarbocyanine iodide (DTTCI), diethyloxatricarbocyanine iodide (DOTCI), and 1,1',3,3,3',3'-hexamethylindotricarbocyanine iodide (HITCI), which are cationic and possess absorption maxima at 772, 695, and 750 nm, respectively, in DMSO. In buffered aqueous solutions, these dyes demonstrated extensive ground-state aggregation in aqueous solvents when compared to DMSO. In the presence of double-stranded DNA (dsDNA), the fluorescence emission spectra revealed enhancement ratios of bound-to-free dye ranging from 4.5 for DOTCI to 128 for DTTCI. Spectrophotometric titrations and Scatchard analyses of the dye-dsDNA complexes yielded nonlinear plots, suggestive of possible multiple binding sites on the DNA. Viscometric titrations of the complexes showed increased solution viscosities for DTTCI, consistent with an unraveling and lengthening of the dsDNA upon complexation. Fluorescence lifetime data of the dye-dsDNA complexes showed longer lifetimes exhibited by these dyes in the presence of the dsDNA compared with those in solutions with no DNA.
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24

Zhu, Ruixue, Rong Lü, and Anchi Yu. "Erratum: Aggregation Behaviors of Tricarbocyanine dye in Water and in AOT Reverse Micelles." Chinese Journal of Chemistry 29, no. 11 (November 2011): 2565. http://dx.doi.org/10.1002/cjoc.201180430.

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25

Dimitriev, Oleg P., Johannes Zirzlmeier, Arjun Menon, Yuri Slominskii, and Dirk M. Guldi. "Exciton Dynamics in J- and H-Aggregates of a Tricarbocyanine Near-Infrared Dye." Journal of Physical Chemistry C 125, no. 18 (April 29, 2021): 9855–65. http://dx.doi.org/10.1021/acs.jpcc.0c11593.

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26

Okuda, Kensuke, Yasuyuki Okabe, Tetsuya Kadonosono, Takahiro Ueno, Bahaa G. M. Youssif, Shinae Kizaka-Kondoh, and Hideko Nagasawa. "2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe forin VivoImaging of Tumor Hypoxia." Bioconjugate Chemistry 23, no. 3 (February 22, 2012): 324–29. http://dx.doi.org/10.1021/bc2004704.

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27

Hirano, Tomoya, Jun Akiyama, Shuichi Mori, and Hiroyuki Kagechika. "Modulation of intramolecular heterodimer-induced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensor." Organic & Biomolecular Chemistry 8, no. 24 (2010): 5568. http://dx.doi.org/10.1039/c0ob00207k.

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28

Kiyose, Kazuki, Hirotatsu Kojima, Yasuteru Urano, and Tetsuo Nagano. "Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore." Journal of the American Chemical Society 128, no. 20 (May 2006): 6548–49. http://dx.doi.org/10.1021/ja060399c.

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29

Obinu, Antonella, Elisabetta Gavini, Giovanna Rassu, Federica Riva, Alberto Calligaro, Maria Cristina Bonferoni, Marcello Maestri, and Paolo Giunchedi. "Indocyanine Green Loaded Polymeric Nanoparticles: Physicochemical Characterization and Interaction Studies with Caco-2 Cell Line by Light and Transmission Electron Microscopy." Nanomaterials 10, no. 1 (January 11, 2020): 133. http://dx.doi.org/10.3390/nano10010133.

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Biomedical applications of nanoparticles (NPs) have reached an increasing development in recent years. Recently, we demonstrated that newly synthesized poly (ethyl 2-cyanoacrylate) nanoparticles (PECA-NPs) are possible antitumor agents due to their cytotoxicity for cancer cells. Indocyanine green (ICG), an amphiphilic tricarbocyanine fluorescent dye, is widely used for the detection of tumoral extension in different organs during clinical surgery. Moreover, this fluorescent agent is unstable and it has a rapid clearance in physiological conditions in vivo. In this study, ICG was charged in PECA-NPs to improve its aqueous stability and make easier its use for the identification of tumor cells. Microscopic and ultrastructural aspects concerning the related in vitro interactions between ICG-loaded NPs and tumor cell culture were investigated. Obtained results showed an effective stabilization of ICG; furthermore, color inclusions inside the cells treated with ICG-loaded NPs demonstrated the internalization of NPs with associated ICG. Transmission electron microscopy (TEM) analysis demonstrated the cytoplasmic presence of coated vesicles (Ø ≤ 100 nm), hypothesizing their involvement in the mechanism of endocytosis. Therefore, ICG-loaded NPs could be proposed as agents for tumor diagnosis, hypothesizing also in the future a specific therapeutic treatment.
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30

Persico, Marco Giovanni, Manuela Marenco, Gianluca De Matteis, Giulia Manfrinato, Giorgio Cavenaghi, Adele Sgarella, Carlo Aprile, and Lorenzo Lodola. "99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits." Contrast Media & Molecular Imaging 2020 (January 22, 2020): 1–11. http://dx.doi.org/10.1155/2020/3629705.

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Recent developments in sentinel lymph node (SLN) and radio occult lesion localization (ROLL) highlight the need for a multimodal contrast agent, providing better presurgical PET imaging and improved intraoperative mapping thanks to fluorescence detection. For this reason, we have studied a trimodal SLN/ROLL targeting agent (99mTc-68Ga-ICG) with commercially available kits of macroaggregated or nanocolloidal albumin (MA/NC-HSA). 68Ga PET imaging does provide better spatial resolution and makes it possible to predict signal intensity during surgery. The presence of 99mTc assesses the efficacy of these compounds in vitro and also during the surgery procedure. The aim of this study was to optimise the labelling and tagging of these two radiopharmaceuticals and assess their yields and stability. Kits of MA/NC-HSA particles (Pulmocis® and NanoAlbumon®) were used for sequential radiolabelling with 99mTc and 68Ga. Fluorescent tagging was performed using indocyanine green, a tricarbocyanine dye. The ITLC radiochemical purity of the trilabelled MA/NC-HSA was >95%. Fluorescent purity was measured by scanning the strips with a PhotoDynamicEye probe. Finally, in vitro stability tests, performed with DTPA and human serum solutions, assessed the efficacy of fluorescent tagging and radiolabelling.
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31

Silori, Yogita, Pankaj Seliya, and Arijit K. De. "Ultrafast Excited-State Dynamics of Tricarbocyanine Dyes Probed by Two-Dimensional Electronic Spectroscopy: Polar Solvation vs Photoisomerization." Journal of Physical Chemistry B 124, no. 31 (July 9, 2020): 6825–34. http://dx.doi.org/10.1021/acs.jpcb.0c01333.

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32

Sharanov, Illya, Yuri Slominskii, Alexander Ishchenko, Alexander Fedoryak, and Oleg Dimitriev. "Single-photon upconversion via hot-band absorption and assessment of the laser cooling effect of tricarbocyanine dyes." Chemical Physics Impact 2 (June 2021): 100026. http://dx.doi.org/10.1016/j.chphi.2021.100026.

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33

Soper, Steven A., Benjamin L. Legendre, and Jiping Huang. "Evaluation of thermodynamic and photophysical properties of tricarbocyanine near-IR dyes in organized media using single-molecule monitoring." Chemical Physics Letters 237, no. 3-4 (May 1995): 339–45. http://dx.doi.org/10.1016/0009-2614(95)00314-t.

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34

Beckford, Garfield, Eric Owens, Maged Henary, and Gabor Patonay. "The solvatochromic effects of side chain substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin." Talanta 92 (April 2012): 45–52. http://dx.doi.org/10.1016/j.talanta.2012.01.029.

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35

Sudeep, P. K., K. Takechi, and Prashant V. Kamat. "Harvesting Photons in the Infrared. Electron Injection from Excited Tricarbocyanine Dye (IR-125) into TiO2and Ag@TiO2Core−Shell Nanoparticles." Journal of Physical Chemistry C 111, no. 1 (January 2007): 488–94. http://dx.doi.org/10.1021/jp0665022.

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36

Zheng, Gang, Hui Li, Kathy Yang, Dana Blessington, Kai Licha, Sissel Lund-Katz, Britton Chance, and Jerry D. Glickson. "Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia." Bioorganic & Medicinal Chemistry Letters 12, no. 11 (June 2002): 1485–88. http://dx.doi.org/10.1016/s0960-894x(02)00193-2.

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37

Flanagan, James H. Jr, Benjamin L. Legendre, Robert P. Hammer, and Steven A. Soper. "Binary Solvent Effects in Capillary Zone Electrophoresis with Ultrasensitive Near-IR Fluorescence Detection of Related Tricarbocyanine Dyes and Dye-Labeled Amino Acids." Analytical Chemistry 67, no. 2 (January 1995): 341–47. http://dx.doi.org/10.1021/ac00098a018.

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38

Zheng, Gang, Hui Li, Kathy Yang, Dana Blessington, Kai Licha, Sissel Lund-Katz, Britton Chance, and Jerry D. Glickson. "ChemInform Abstract: Tricarbocyanine Cholesteryl Laurates Labeled LDL: New Near Infrared Fluorescent Probes (NIRFs) for Monitoring Tumors and Gene Therapy of Familial hypercholesterolemia." ChemInform 33, no. 38 (May 19, 2010): no. http://dx.doi.org/10.1002/chin.200238190.

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39

Soper, Steven A., and Quincy L. Mattingly. "Steady-State and Picosecond Laser Fluorescence Studies of Nonradiative Pathways in Tricarbocyanine Dyes: Implications to the Design of Near-IR Fluorochromes with High Fluorescence Efficiencies." Journal of the American Chemical Society 116, no. 9 (May 1994): 3744–52. http://dx.doi.org/10.1021/ja00088a010.

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40

Turrado-Rodriguez, Victor, Dulce Nombre De Maria Momblan, Ainitze Ibarzabal, Alba Torroella, Rafael Gerardo Diaz Del Gobo, and Antonio Maria De Lacy Fortuny. "PS02.022: INDOCYANINE GREEN: A USEFUL TOOL IN MINIMALLY INVASIVE ESOPHAGEAL CANCER SURGERY." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 126. http://dx.doi.org/10.1093/dote/doy089.ps02.022.

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Abstract Background Minimally invasive approach to esophageal cancer has been accepted as the standard of care in many centers. Nontheless, some technical difficulties are encountered during surgery. A proper vascularization of the gastric tube is mandatory to avoid the dreadful complication of a leak or of gastric conduit necrosis. On the other hand, there is controversy on the identification of sentinel lymph node in early esophageal cancer and on the extent of lymphadenectomy in locally advanced tumours. Indocyanine green (ICG) is a sterile, anionic, water-soluble but relatively hydrophobic, tricarbocyanine molecule, which is bound to plasma proteins when intravenously injected. It is extracted by the liver appearing in the bile around 8 minutes after injection. When injected outside the blood vessels, ICG reaches the nearest lymph node within 15 minutes and after 1 to 2 hours it binds to the regional lymph nodes. The usual dose of ICG is 0.1 - 0.5mg/mL/kg. ICG becomes fluorescent once excited with near-infrared (NIR) light at about 820 nm. The fluorescence released by ICG may be detected using specially developed cameras. Methods A systematic review of the literature of ICG in esophageal surgery was carried on February 2018 using the following terms: esophagus, indocyanine green, ICG, surgery, angiography, lymph node, and combinations of the above. Results The technique of ICG angiography for vascular assessment of the gastroepiploic arcade and gastric conduit is explained and the published results are review. The use of ICG for the evaluation of sentinel lymph node in early esophageal cancer and of lymph node mapping for regional lymph nodes is explained and current evidence is reviewed. Conclusion ICG use in esophageal surgery is still a novel and promising technique. It could help to reduce anastomotic leak by means of vascular assessment of the gastric conduit, locate lymph nodes out of the usual fields of lymphadenectomy and locate the sentinel lymph node in early esophageal cancer Disclosure All authors have declared no conflicts of interest.
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41

Dunn, B., F. Nishida, R. Toda, J. I. Zink, T. H. Allik, S. Chandra, and J. A. Hutchinson. "Advances in Dye-Doped Sol-Gel Lasers." MRS Proceedings 329 (1993). http://dx.doi.org/10.1557/proc-329-267.

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AbstractThe sol-gel process is a solution synthesis technique which provides a low temperature chemical route for the preparation of rigid transparent matrices. A number of laser dyes have been incorporated in different sol-gel matrices and tunable laser action has been demonstrated with these materials. This paper extends the sol-gel laser field into two significant areas, infrared dyes and pyrromethenes. The work with the tricarbocyanine dyes shows the versatility of sol-gel chemistry as organic modifications produce a favorable environment for the dye molecules. The results with the pyrromethene system show a considerable increase in output energy and offer the promise of longer laser lifetimes.
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42

Exner, Rüdiger M., Fernando Cortezon‐Tamarit, and Sofia I. Pascu. "Explorations into the Effect of meso ‐Substituents in Tricarbocyanine Dyes: A Path to Diverse Biomolecular Probes and Materials." Angewandte Chemie, December 28, 2020. http://dx.doi.org/10.1002/ange.202008075.

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43

Exner, Rüdiger M., Fernando Cortezon‐Tamarit, and Sofia I. Pascu. "Explorations into the Effect of meso ‐Substituents in Tricarbocyanine Dyes: A Path to Diverse Biomolecular Probes and Materials." Angewandte Chemie International Edition, December 28, 2020. http://dx.doi.org/10.1002/anie.202008075.

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44

MAKIN, S. M., R. I. KRUGLIKOVA, O. A. SHAVRYGINA, T. P. KOLOBOVA, T. P. POPOVA, and T. K. TAGIROV. "ChemInform Abstract: Chemistry of Enol Ethers. Part 79. Reaction of Glutaconic Aldehyde Acetals and Their Derivatives with Heterocyclic Compounds. Synthesis of Tricarbocyanine Dyes." ChemInform 19, no. 7 (February 16, 1988). http://dx.doi.org/10.1002/chin.198807322.

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