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Relevant bibliographies by topics / Tricarboxylic acid (TCA) cycle

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Academic literature on the topic 'Tricarboxylic acid (TCA) cycle'

Author: Grafiati

Published: 6 August 2021

Last updated: 4 February 2022

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Journal articles on the topic "Tricarboxylic acid (TCA) cycle"

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Gibala, Martin J., Dave A. MacLean, Terry E. Graham, and Bengt Saltin. "Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise." American Journal of Physiology-Endocrinology and Metabolism 275, no. 2 (1998): E235—E242. http://dx.doi.org/10.1152/ajpendo.1998.275.2.e235.

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We examined the relationship between tricarboxylic acid (TCA) cycle intermediate (TCAI) pool size, TCA cycle flux (calculated from leg O2uptake), and pyruvate dehydrogenase activity (PDHa) in human skeletal muscle. Six males performed moderate leg extensor exercise for 10 min, followed immediately by intense exercise until exhaustion (3.8 ± 0.5 min). The sum of seven measured TCAI (ΣTCAI) increased ( P ≤ 0.05) from 1.39 ± 0.11 at rest to 2.88 ± 0.31 after 10 min and to 5.38 ± 0.31 mmol/kg dry wt at exhaustion. TCA cycle flux increased ∼70-fold during submaximal exercise and was ∼100-fold highe

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Choi, Inseok, Hyewon Son, and Jea-Hyun Baek. "Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses." Life 11, no. 1 (2021): 69. http://dx.doi.org/10.3390/life11010069.

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The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins. In the eukaryotic system, the TCA cycle occurs completely in mitochondria, while the intermediates of the TCA cycle are retained inside mitochondria due to their polarity and hydrophilicity. Under cell stress conditions, mitochondria can become disrupted and release their contents, which act as danger signals in the cytosol. Of note, the TCA cycle intermediates may also leak from dysfu

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Jiménez-Uribe, Alexis Paulina, Estefani Yaquelin Hernández-Cruz, Karla Jaqueline Ramírez-Magaña, and José Pedraza-Chaverri. "Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases." Biomolecules 11, no. 9 (2021): 1259. http://dx.doi.org/10.3390/biom11091259.

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Mitochondria are complex organelles that orchestrate several functions in the cell. The primary function recognized is energy production; however, other functions involve the communication with the rest of the cell through reactive oxygen species (ROS), calcium influx, mitochondrial DNA (mtDNA), adenosine triphosphate (ATP) levels, cytochrome c release, and also through tricarboxylic acid (TCA) metabolites. Kidney function highly depends on mitochondria; hence mitochondrial dysfunction is associated with kidney diseases. In addition to oxidative phosphorylation impairment, other mitochondrial

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Brown, Amy C., Holden SH MacRae, and Nathan S. Turner. "Tricarboxylic-Acid-Cycle Intermediates and Cycle Endurance Capacity." International Journal of Sport Nutrition and Exercise Metabolism 14, no. 6 (2004): 720–29. http://dx.doi.org/10.1123/ijsnem.14.6.720.

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The purpose of this study was to determine whether ingestion of a multinutrient supplement containing 3 tricarboxylic-acid-cycle intermediates (TCAIs; pyridoxine-alpha-ketoglutarate, malate, and succinate) and other substances potentially supporting the TCA cycle (such as aspartate and glutamate) would improve cyclists’ time to exhaustion during a submaximal endurance-exercise test (~ 70% to 75% VO2peak) and rate of recovery. Seven well-trained male cyclists (VO2max 67.4 2.1 mL · kg–1 · min–1, 28.6 ± 2.4 y) participated in a randomized, double-blind crossover study for 7 wk. Each took either t

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Hotchkiss, R. S., S. K. Song, J. J. Neil, et al. "Sepsis does not impair tricarboxylic acid cycle in the heart." American Journal of Physiology-Cell Physiology 260, no. 1 (1991): C50—C57. http://dx.doi.org/10.1152/ajpcell.1991.260.1.c50.

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Sepsis has been reported to cause mitochondrial dysfunction and inhibition of key enzymes that regulate the tricarboxylic acid (TCA) cycle. We investigated the effect of sepsis on high-energy phosphates, glycolytic and TCA cycle intermediates, and specific amino acids that are involved in regulating the size of the TCA cycle pool during changes in metabolic state of the heart. Sepsis was induced in 12 female rats by the cecal ligation and perforation technique under halothane anesthesia; seven control rats underwent cecal manipulation without ligation. At 36-42 h postsurgery, the rats were rea

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Dhandayuthapani, S., and K. Nellaiappan. "Tricarboxylic acid cycle enzymes of a pseudophyllid cestode Penetrocephalus ganapatii." Journal of Helminthology 64, no. 1 (1990): 51–53. http://dx.doi.org/10.1017/s0022149x00011871.

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ABSTRACTStudies on the tricarboxylic acid cycle (TCA cycle) enzymes of Penetrocephalus ganapatii reveal that the TCA cycle is only partially operative, as some of the enzymes at the start of the cycle viz. citrate synthase, aconitase and isocitrate dehydrogenase are found to be low in their activities. The high activities of malate dehydrogenase and fumarase, showing affinity towards a reverse direction, indicate that the TCA cycle operates in the reverse direction resulting in the formation of fumarate. The low succinate dehydrogenase/fumarate reductase ratio suggests that ATP generation may

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Gibala, M. J., M. A. Tarnopolsky, and T. E. Graham. "Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling." American Journal of Physiology-Endocrinology and Metabolism 272, no. 2 (1997): E239—E244. http://dx.doi.org/10.1152/ajpendo.1997.272.2.e239.

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Previous studies have used the muscle concentration of citrate + malate + fumarate to estimate tricarboxylic acid (TCA) cycle pool size in humans [e.g., Am. J. Physiol. 259 (Cell Physiol. 28): C834-C841, 1990]. Our purpose was to quantify changes in individual TCA cycle intermediates (TCAI) and total pool size by measuring the concentrations of the eight TCAI in human muscle. Eight males cycled to exhaustion (Exh) at approximately 70% of their maximal oxygen uptake, and biopsies were obtained from the vastus lateralis at rest and during exercise. Succinyl-CoA was not consistently detectable, b

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Zhu, Yefei, Yan Q. Xiong, Marat R. Sadykov, et al. "Tricarboxylic Acid Cycle-Dependent Attenuation of Staphylococcus aureus In Vivo Virulence by Selective Inhibition of Amino Acid Transport." Infection and Immunity 77, no. 10 (2009): 4256–64. http://dx.doi.org/10.1128/iai.00195-09.

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ABSTRACT Staphylococci are the leading causes of endovascular infections worldwide. Commonly, these infections involve the formation of biofilms on the surface of biomaterials. Biofilms are a complex aggregation of bacteria commonly encapsulated by an adhesive exopolysaccharide matrix. In staphylococci, this exopolysaccharide matrix is composed of polysaccharide intercellular adhesin (PIA). PIA is synthesized when the tricarboxylic acid (TCA) cycle is repressed. The inverse correlation between PIA synthesis and TCA cycle activity led us to hypothesize that increasing TCA cycle activity would d

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Patterson, Rainey E., Srilaxmi Kalavalapalli, Caroline M. Williams, et al. "Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity." American Journal of Physiology-Endocrinology and Metabolism 310, no. 7 (2016): E484—E494. http://dx.doi.org/10.1152/ajpendo.00492.2015.

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The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism and is closely coupled to cellular respiration, free radical generation, and inflammation. Oxidative flux through the TCA cycle is induced during hepatic insulin resistance, in mice and humans with simple steatosis, reflecting early compensatory remodeling of mitochondrial energetics. We hypothesized that progressive severity of hepatic insulin resistance and the onset of nonalcoholic steatohepatitis (NASH) would impair oxidative flux through the hepatic TCA cycle. Mice (C57/BL6) were fed a high- tran

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Kelleher, J. K., B. M. Bryan, R. T. Mallet, A. L. Holleran, A. N. Murphy, and G. Fiskum. "Analysis of tricarboxylic acid-cycle metabolism of hepatoma cells by comparison of 14CO2 ratios." Biochemical Journal 246, no. 3 (1987): 633–39. http://dx.doi.org/10.1042/bj2460633.

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The CO2-ratios method is applied to the analysis of abnormalities of TCA (tricarboxylic acid)-cycle metabolism in AS-30D rat ascites-hepatoma cells. This method utilizes steady-state 14CO2-production rates from pairs of tracers of the same compound to evaluate TCA-cycle flux patterns. Equations are presented that quantitatively convert CO2 ratios into estimates of probability of flux through TCA-cycle-related pathways. Results of this study indicated that the ratio of 14CO2 produced from [1,4-14C]succinate to 14CO2 produced from [2,3-14C]succinate was increased by the addition of glutamine (5

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Dissertations / Theses on the topic "Tricarboxylic acid (TCA) cycle"

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Levisson, Renée. "Implementation of a straightforward derivatizationmethod for the simultaneous analysis of short chainfatty acids and tricarboxylic acid cycle metabolitesby LC-qToF-MS." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93417.

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Short-chain fatty acids (SCFAs) and the tricarboxylic acid (TCA) cycle metabolites aresmall hydrophilic compounds that play crucial roles in biological species ranging fromenergy metabolism, immune homeostasis to cellular signalling. There is a need for reliableand precise quantification of these metabolites in biological matrices as they can providecrucial information of metabolic status and potentially be used as diagnostic biomarkersfor different pathological and physiological conditions. However, their retention andseparation in traditional reversed-phase system, without chemical derivatiz

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Tatke, Gorakh Digambar. "Elucidating The Role of MifS-MifR Two-Component System in Regulating Pseudomonas aeruginosa Pathogenicity." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/3002.

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Pseudomonas aeruginosa is a Gram-negative, metabolically versatile, opportunistic pathogen that exhibits a multitude of virulence factors, and is extraordinarily resistant to a gamut of clinically significant antibiotics. This ability is in part mediated by two-component systems (TCS) that play a crucial role in regulating virulence mechanisms, metabolism and antibiotic resistance. Our sequence analysis of the P. aeruginosa PAO1 genome revealed the presence of two open reading frames, mifS and mifR, which encodes putative TCS proteins, a histidine sensor kinase MifS and a response regulator Mi

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Meyer, Frederik. "Regulatory interactions of enzymes of the citric acid cycle in Bacillus subtilis." Thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://hdl.handle.net/11858/00-1735-0000-000D-F1AF-E.

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Kanao, Tadayoshi. "Studies on the reductive tricarboxylic acid cycle from the green sulfur bacterium Chlorobium limicola." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/149456.

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Goerner-Potvin, Patricia. "Transcriptomic analysis of Sinorhizobium meliloti 1021 focusing on tricarboxylic acid cycle, nitrogen fixation, and carbon metabolism pathways." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123171.

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Sinorhizobium meliloti 1021 is a nitrogen-fixing symbiont of legume plants Medicago, Melilotus and Trigonella. This bacterium is a model organism for tricarboxylic acid (TCA) cycle, and other genetic studies. The complete S. meliloti 1021 bacteroid transcriptome was sequenced and was compared to the complete sequenced transcriptome of free-living cells grown on malate a as sole carbon source. Twenty-seven genes were downregulated more than 20 folds when compared to the control treatment malate. Most of these downregulated genes were of unknown function or part of the carbohydrate transport and

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Doolittle, Lauren May. "The Impact of Alveolar Type II Cell Mitochondrial Damage and Altered Energy Production on Acute Respiratory Distress Syndrome Development During Influenza A Virus Infection." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu159224389333959.

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Rico, Marta de Oliveira Pimentel Rosado. "Analysis of tricarboxylic acids in cancer by LC-MS." Master's thesis, 2013. http://hdl.handle.net/10451/29616.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Metabolomics is the comprehensive and quantitative study of metabolites in a biological system. The Tricarboxylic acid (TCA) cycle intermediates, such as citric acid, isocitric acid, alpha-ketoglutaric acid and fumaric acid are important metabolites for the energy production in the cells. In this cycle, the enzyme Isocitrate Dehydrogenase (IDH) converts the isocitrate to alpha-ketoglutarate, but in some types of cancer cells, IDH is mutated and L-hydroxyglutaric acid is formed.

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Lin, Tzu-Yu, and 林姿余. "The Effect of Tricarboxylic Acid Cycle Metabolites in Metabolic Engineering Escherichia coli." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/wjv968.

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碩士<br>國立中興大學<br>生命科學系所<br>107<br>Global warming and climate change are caused by overuse of fossil fuels, such as coal and petroleum, producing such as carbon dioxide, methane, and nitrous oxide, resulting in greenhouse effect. The issue of carbon dioxide reduction has not only been a regional or even global issue. In recent years, the issue of carbon dioxide emission is not only a regional but even global issue. If carbon dioxide can be recycled through microorganisms and convered to petrochemicals alternatives , the use of non-renewable energy can be reduced. In previous studies, a set of re

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Yu, Chia-Hua, and 余佳樺. "Characterization of Escherichia coli with Reductive Tricarboxylic Acid Cycle Constructed by Synthetic Biological Technique." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/20412377913261094973.

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碩士<br>國立中興大學<br>生命科學系所<br>104<br>The impact of global warming caused by greenhouse gas is an issue to nowadays. We propose to develop a chemo-synthetic autotroph system that can fix carbon dioxide. We expect to fulfill a set of reductive tricarboxylic acid (rTCA) cycle genes in Escherichia coli by introducing α-ketoglutarate:ferredoxin oxidoreductase, ATP citrate lyase, fumarate reductase, and succinate dehydrogenase from Chlorobium tepidum TLS. With 0.2% glucose as carbon and electron source, rTCA engineered strain can grow faster than control strain either under aerobic or anaerobic conditio

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Wu, Dong-Yan, and 吳東諺. "Molecular Characterization of Chemoautotrophic Escherichia coli with Reductive Tricarboxylic Acid Cycle by Metabolic Engineering." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/95596547143136298785.

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碩士<br>國立中興大學<br>生命科學系所<br>105<br>The increase of atmospheric carbon dioxide, which is considered as a major greenhouse gas, plays an important role in global warming. Therefore, finding a method to decrease CO2 is an attractive global issue. A set of reductive tricarboxylic acid (rTCA) cycle genes have been introduced from Chlorobium tepidum TLS to Escherichia coli. It was confirmed that genetic engineering strain could fix CO2 in anaerobic culture using 0.2% glucose as carbon sources. In this study, the chemoautotrophic potential and characteristics of E. coli with rTCA cycle was determined

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Books on the topic "Tricarboxylic acid (TCA) cycle"

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Borges, Karin. Triheptanoin in Epilepsy and Beyond. Edited by Dominic P. D’Agostino. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0034.

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Triheptanoin, the triglyceride of heptanoate (C7 fatty acid), is a novel treatment that is being used to treat patients with rare genetic metabolic disorders. When taken orally, triheptanoin is hydrolyzed in the gastrointestinal tract to heptanoate, which is thought to diffuse into the blood and body. Heptanoate and its liver ketone metabolites are then metabolized within cells to propionyl-CoA, which after carboxylation produces succinyl-CoA, resulting in anaplerosis—the refilling of a deficient tricarboxylic acid cycle. Here, data are summarized and discussed in relation to triheptanoin’s an

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Book chapters on the topic "Tricarboxylic acid (TCA) cycle"

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Li, Ting, Christopher Copeland, and Anne Le. "Glutamine Metabolism in Cancer." In The Heterogeneity of Cancer Metabolism. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_2.

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AbstractMetabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, cancer cells have reprogrammed metabolism in order to fulfill their energy requirements. These cells display crucial modifications in many metabolic pathways, such as glycolysis and glutaminolysis, which include the tricarboxylic acid (TCA) cycle, the electron transport chain (ETC), and the pentose phosphate pathway (PPP) [1]. Since the discovery of the Warburg effect, it has been shown that the metabolism of cancer cells plays a critical role in cancer survival and growth. More recent research suggests that the involvement of glutamine in cancer metabolism is more significant than previously thought. Glutamine, a nonessential amino acid with both amine and amide functional groups, is the most abundant amino acid circulating in the bloodstream [2]. This chapter discusses the characteristic features of glutamine metabolism in cancers and the therapeutic options to target glutamine metabolism for cancer treatment.

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Gooch, Jan W. "Tricarboxylic Acid Cycle." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_15018.

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Gupta, Rani, and Namita Gupta. "Tricarboxylic Acid Cycle." In Fundamentals of Bacterial Physiology and Metabolism. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0723-3_12.

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Fromm, Herbert J., and Mark S. Hargrove. "The Tricarboxylic Acid Cycle." In Essentials of Biochemistry. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19624-9_9.

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Chesworth, J. M., T. Stuchbury, and J. R. Scaife. "The Tricarboxylic Acid Cycle." In An Introduction to Agricultural Biochemistry. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-009-1441-4_11.

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Smith, C. A., and E. J. Wood. "The tricarboxylic acid cycle." In Energy in Biological Systems. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3124-7_4.

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Dennis, David T. "The Tricarboxylic Acid Cycle." In The Biochemistry of Energy Utilization in Plants. Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3121-3_7.

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Gupta, Rani, and Namita Gupta. "Alternate Tricarboxylic Acid Cycle." In Fundamentals of Bacterial Physiology and Metabolism. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0723-3_13.

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Cohen, G. N. "The Tricarboxylic Acid Cycle and the Glyoxylate Bypass." In Microbial Biochemistry. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8908-0_8.

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Cohen, Georges N. "The tricarboxylic acid cycle and the glyoxylate bypass." In Microbial Biochemistry. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-1-4020-2237-1_8.

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Conference papers on the topic "Tricarboxylic acid (TCA) cycle"

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Vasyliv, Oresta M., Olga D. Maslovska, Yaroslav P. Ferensovych, Oleksandr I. Bilyy, and Svitlana O. Hnatush. "Interconnection between tricarboxylic acid cycle and energy generation in microbial fuel cell performed by desulfuromonas acetoxidans IMV B-7384." In SPIE Sensing Technology + Applications, edited by Nibir K. Dhar and Achyut K. Dutta. SPIE, 2015. http://dx.doi.org/10.1117/12.2176222.

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Grassian, Alexandra R., Seth Parker, Shawn Davidson, et al. "Abstract B159: Heterozygous IDH1 mutations modify the citric acid (TCA) cycle metabolism and sensitize cells to inhibition of mitochondrial respiration/oxidative phosphorylation." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-b159.

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