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Journal articles on the topic 'Trichoepithelioma multiplex'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Centurión, Santiago A., Robert A. Schwartz, and W. Clark Lambert. "Trichoepithelioma Papulosum Multiplex." Journal of Dermatology 27, no. 3 (2000): 137–43. http://dx.doi.org/10.1111/j.1346-8138.2000.tb02139.x.

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2

Igawa, Ken, Toshiyuki Yamamoto, and Kiyoshi Nishioka. "Vellous Hair in Trichoepithelioma papulosum multiplex." Dermatology 209, no. 4 (2004): 338–39. http://dx.doi.org/10.1159/000080860.

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3

MAEKAWA, Tomoko, Yumiko KAKU, Kayo HARADA, and Kazunori URABE. "A Case of Trichoepithelioma Multiplex in an Infant." Nishi Nihon Hifuka 76, no. 6 (2014): 533–34. http://dx.doi.org/10.2336/nishinihonhifu.76.533.

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4

N., Priyadharshini, Harini Irri, and Sathyanarayanan R. "Multiple familial trichoepitheliomas: a case report." International Journal of Research in Dermatology 7, no. 3 (2021): 487. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20211719.

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<p class="abstract">Trichoepithelioma is a rare benign adnexal tumor that differentiates towards the folliculo-sebaceous-apocrine unit (trichoblast). It may present as solitary non-familial lesion or multiple lesions as a part of autosomal dominant inherited syndrome known as multiple familial Trichoepithelioma. Multiple familial trichoepithelioma is a relatively rare, disfiguring, benign adnexal neoplasm diagnosed by centrofacial distribution of papules and nodules, positive family history, related histopathological findings and can rarely undergo malignant transformation. Treatment is

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5

Rao Venkata Mahipathy, Surya Rao, Narayanamurthy Sundaramurthy, Vimal Chander Rajamanohar, Alagar Raja Durairaj, and Manimaran Ramachandran. "Giant solitary trichoepithelioma masquerading as basal cell carcinoma." International Surgery Journal 5, no. 7 (2018): 2649. http://dx.doi.org/10.18203/2349-2902.isj20182790.

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Trichoepithelioma is a rare benign adnexal tumour which can be of solitary non-familial type or multiple familial trichoepitheliomas. Here authors describe a middle-aged patient who presented with a swelling of the left nasolabial region diagnosed clinically as a basal cell carcinoma but proved to be a giant solitary trichoepithelioma (GST) following histopathological examination. This case is presented due to the rarity and the difficulty encountered in diagnosis of the case.

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6

Tenea, Daniela. "Trichoepithelioma Multiplex: A Study of the Relationship between the Anatomical Location and the Histopathological Features." British Journal of Medicine and Medical Research 3, no. 4 (2013): 1015–29. http://dx.doi.org/10.9734/bjmmr/2013/2930.

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7

Dr., DS Gupta, Saubhagya S. Agrawal Dr., Aashita jain Dr., Shilpi Shrivastava Dr., Nakul Chaudhary Dr., and Deepika Saini Dr. "A Rare Case of Trichoepithelioma on Unusual Location." A Rare Case of Trichoepithelioma on Unusual Location 8, no. 11 (2023): 3. https://doi.org/10.5281/zenodo.10212719.

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Purpose: Trichoepithelioma is a very rare benign tumor of the skin. Trichoepitheliomas originate in hair follicles and occur in the head and neck. It is found on the scalp, nose, and forehead, but very rarely on the hairless part of the upper lip. Therefore, removal of trichoepithelioma was performed to improve facial aesthetics, which was the patient's primary concern.Material& methods/ Case description: An adult male patient reported to the department with the solitary nodular lesion on the non-hair bearing area of left upper lip.Result: Post-op after 3 months there was no scar formation

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8

Dissanayaka, D. W. V. N., D. K. B. Dassanayaka, and P. R. Jayasooriya. "Clinical, Histopathological, and Management Challenges of Multiple Familial Trichoepithelioma: A Case Report of a Patient Presenting with Multiple Facial Papules." Case Reports in Dentistry 2020 (September 9, 2020): 1–6. http://dx.doi.org/10.1155/2020/5648647.

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Trichoepitheliomas (TE) are benign skin tumours of the pilosebaceous apocrine unit with follicular differentiation. Multiple familial trichoepithelioma (MFT) is a considerably rare condition inherited in an autosomal dominant pattern. We present a case of a 15-year-old male who presented with multiple papulo-nodular lesions in the central face and a family history of a similar type of lesions from his mother. Significance of consideration of various clinical differential diagnoses with serious pathological outcomes, strategies followed in the diagnosis including histopathological evaluation ai

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9

Gaydina, Tatiana A., Anton S. Dvornikov, Polina A. Skripkina, Olga I. Patsap, and Anastasiia A. Buianova. "Differential diagnosis of Brooke–Spiegler syndrome in a young woman with multiple trichoepitheliomas." Russian Journal of Skin and Venereal Diseases 25, no. 6 (2023): 5–16. http://dx.doi.org/10.17816/dv112260.

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BrookeSpiegler syndrome (Brooke-Spiegler syndrome; OMIM #605041) is a rare, autosomal dominant inherited monogenic disease caused by mutations in gene CYLD with its different penetrance. It is clinically manifested by the development of multiple neoplasms of skin appendages such as spiradenoma, cylindroma, spiradenocylindroma and trichoepithelioma. Several phenotypic variants with mutations in gene CYLD have been described in the scientific literature. They are classic BrookeSpiegler syndrome; multiple familial trichoepithelioma syndrome (multiple trichoepitheliomas without cylindromas,

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10

Tiodorović, Danica, and Miljan Krstić. "Clinical, Histological and Dermoscopic Findings in Familial Cylindromatosis: a Report of Two Cases." Serbian Journal of Dermatology and Venereology 7, no. 2 (2015): 75–82. http://dx.doi.org/10.1515/sjdv-2015-0008.

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Abstract Cylindromas are benign appendage tumors mainly found on the scalp, but they can occur on any hair-bearing skin. Mutations in the cylindromatosis (CYLD) gene, a tumor suppressor gene located on chromosome 16q12–13, are responsible for multiple cylindromas, which are usually inherited in an autosomal dominant way, as in familial cylindromatosis and Brooke-Spiegler syndrome. The latter is characterized by the presence of multiple cylindromas, multiple trichoepitheliomas and spiradenomas. Based on genetic studies and the identification of heterozygous mutations in the same CYLD gene in fa

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11

Mishra, Pragnya P., Puspanjali Sahu, Sarita Panigrahi, Smruti Ranjan Hota, Priya Kumari, and Premanand Panda. "A clinico-histopathological study of skin appendageal tumours in a tertiary health care centre in western Odisha– A case series." IP Archives of Cytology and Histopathology Research 8, no. 3 (2023): 229–33. http://dx.doi.org/10.18231/j.achr.2023.051.

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Skin appendageal tumours (SATs) are those neoplasms that arise from pilosebaceous, apocrine, or eccrine sweat glands. These are a diverse group of tumours with both benign and malignant counterparts. They can be single, multiple, or have a syndromic association with internal malignancies. Benign adnexal tumours are more common, while malignant adnexal tumours are rare, usually locally aggressive, and have the potential for nodal involvement and distant metastasis with a poor clinical outcome. Therefore, proper diagnosis of SATs is important for therapeutic and prognostic reasons.This study aim

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12

Parren, L. J. M. T., K. Munte, V. Winnepenninckx, et al. "Clustered unilateral trichoepitheliomas indicate Type 1 segmental manifestation of multiple familial trichoepithelioma." Clinical and Experimental Dermatology 41, no. 6 (2016): 682–84. http://dx.doi.org/10.1111/ced.12856.

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13

Babbita, S., R. G. Sharada, C. R. V. Narasimhalu, and E. Muthuvel. "Multiple Trichoepithelioma." Biomedicine 40, no. 3 (2020): 399–401. http://dx.doi.org/10.51248/.v40i3.40.

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Multiple non-familial Trichoepithelioma is a rare benign adnexal tumour that originates from pilosebaceous follicle. The incidence is predominantly at puberty or early part of childhood. The common sites of occurance of trichoepithelioma are upper lip, forehead, scalp and nose. Trichoepithelioma in young women may lead to cosmetic disfigurement. We report a case of multiple non-familial trichoepithelioma who presented with complaints of multiple skin coloured raised lesions on her face since the age of 15 years. Keywords: Benign adnexal tumour; horn cyst; multiple non-familial trichoepit

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14

Kaiser, Adeel, Robert J. Spence, Anil Parwani, Tarik Tihan, and Terry L. Barrett. "Basaloid Follicular Hamartoma with Trichoblastomatous Proliferations." Journal of Cutaneous Medicine and Surgery 7, no. 5 (2003): 395–98. http://dx.doi.org/10.1177/120347540300700506.

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Background: Basaloid follicular hamartomas (BFH) are rare, benign, adnexal lesions with diverse clinical presentations. Previous studies documented BFHs with fibroepithelioma of Pinkus-like proliferations, or proliferations that resemble trichoepitheliomas. Objective: We report on a patient with linear, unilateral BFH and extensive trichoblastomatous proliferations involving the right arm, torso, and leg. An 18-year-old female presented with multiple, hyperkeratotic, linear nodules and plaques limited to her right side from the shoulder to the leg. The lesions had existed since birth and gradu

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15

Amaaoune, F., W. Zidane, M. Akssim, M. Aboudourib, O. Hocar, and S. Amal. "Multiple Nonfamilial Trichoepitheliomas: A Rare Case with Review of the Literature." Scholars Journal of Medical Case Reports 11, no. 05 (2023): 801–4. http://dx.doi.org/10.36347/sjmcr.2023.v11i05.012.

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Trichoepitheliomas are benign tumors of follicular origin and often appear in childhood or early adolescence. They present as small, firm papulonodular lesions of normal skin color or translucent. The lesions gradually increase in size and then stabilize. They sit electively on the face, mainly in the nasolabial folds, on the forehead, chin, and cheeks, and sometimes on the scalp and neck. Trichoepitheliomas can be divided into three subgroups: multiple familial Trichoepitheliomas, solitary non-hereditary Trichoepitheliomas, and desmoplastic Trichoepitheliomas. Nonfamilial multiple trichoepith

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16

Bajaj, Anubha. "The Follicular Benignancy- Desmoplastic Trichoepithelioma." Journal of Clinical and Diagnostic Pathology 1, no. 2 (2020): 9–16. http://dx.doi.org/10.14302/issn.2689-5773.jcdp-20-3218.

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Trichoepithelioma is a benign, cutaneous neoplasm originating from the hair follicle and is categorized into singular trichoepithelioma, multiple trichoepithelioma and desmoplastic trichoepithelioma wherein desmoplastic trichoepithelioma is cogitated as an exceptional, cutaneous adnexal tumour. Desmoplastic trichoepithelioma was initially scripted by Hartzell in 1904 wherein the lesion was described as a benign, cystic epithelioma. Desmoplastic trichoepithelioma can be additionally nomenclated as epithelioma adenoides cysticum, morphea - like epithelioma or sclerosing epithelial hamartoma 1. F

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17

Amaaoune, Fatima, Wassima Zidane, Mohamed Aksim, Maryem Aboudourib, Ouafa Hocar, and Said Amal. "Multiple non-familial trichoepitheliomas: A rare case and a review of the literature." Our Dermatology Online 14, no. 3 (2023): 307–10. http://dx.doi.org/10.7241/ourd.20233.17.

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Trichoepitheliomas are benign tumors of follicular origin often appearing in childhood or early adolescence. They present as small, firm papulonodular lesions of normal skin color or translucent. The lesions gradually increase in size and then stabilize. They sit electively on the face, mainly on the nasolabial folds, forehead, chin, and cheeks, and sometimes on the scalp and neck. Trichoepitheliomas may be divided into three subgroups: multiple familial trichoepitheliomas, solitary non-hereditary trichoepitheliomas, and desmoplastic trichoepitheliomas. Non-familial multiple trichoepitheliomas

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18

Mathur, M., and SK Kedia. "Multiple familial trichoepithelioma: A case report." Journal of College of Medical Sciences-Nepal 6, no. 4 (2012): 64–68. http://dx.doi.org/10.3126/jcmsn.v6i4.6731.

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Trichoepithelioma are benign epidermal appendageal tumour with follicular differentiation. Tumor has been categorized into solitary, multiple and desmoplastic types. The multiple familial trichoepithelioma is autosomal dominant inheritance and rarely seen. Journal of College of Medical Sciences-Nepal,2011,Vol-6,No-4, 64-68 DOI: http://dx.doi.org/10.3126/jcmsn.v6i4.6731

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19

Wagner, G. "Multiple Trichoepitheliome." Aktuelle Dermatologie 33, no. 08/09 (2007): 317–20. http://dx.doi.org/10.1055/s-2007-966743.

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20

Laishram, Sushma, and Piyush Yadav. "Multiple familial trichoepithelioma." Cosmoderma 2 (September 5, 2022): 68. http://dx.doi.org/10.25259/csdm_74_2022.

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21

Monteiro, Ana Filipe, Margarida Rato, Pedro Luís, and Ermelindo Tavares. "Multiple Familial Trichoepithelioma." Acta Médica Portuguesa 31, no. 3 (2018): 180. http://dx.doi.org/10.20344/amp.10383.

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22

Miotto, Isadora Zago, and Ricardo Romiti. "Nonfamilial Multiple Trichoepithelioma." JAMA Dermatology 155, no. 9 (2019): 1070. http://dx.doi.org/10.1001/jamadermatol.2019.1650.

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23

Priambada, Nur Purba, Wendi Prameswari, Fitri Yanti, and Karmele Llano Sanchez. "Multiple Trichoepithelioma pada Kukang (Nycticebus coucang) Jantan di Yayasan Inisiasi Alam Rehabilitasi Indonesia: Studi Kasus." Acta VETERINARIA Indonesiana 4, no. 1 (2016): 1–6. http://dx.doi.org/10.29244/avi.4.1.1-6.

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Berbagai macam neoplasia telah dilaporkan di prosimian tetapi masih sedikit sekali kasus tumor kulit pada kukang yang dilaporkan. Tulisan ini bertujuan untuk membahas kasus multiple trichoepithelioma pada kukang sumatra (N. coucang). Seekor kukang sumatera berjenis kelamin jantan, dewasa, memiliki berat 670 gram, telah diterima oleh Pusat Rehabilitasi Primata Yayasan Inisiasi Alam Rehabilitasi Indonesia (PRP-YIARI), Bogor pada Mei 2014. Pada pemeriksaan fisik ditemukan sebanyak 18 buah bentukan masa di kulitnya dengan diameter yang bervariasi 5-25 mm dan tersebar di seluruh tubuh mulai dari ka

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24

Mandekou-Lefaki, I., G. Theodosiou, F. S. Delli, D. Oikonomou, and M. Papageorgiou. "Multiple Nonfamilial Unilateral Trichoepitheliomas: Report of a Case—Mini Review of the Literature." Case Reports in Dermatological Medicine 2019 (July 14, 2019): 1–4. http://dx.doi.org/10.1155/2019/6821854.

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Trichoepitheliomas are benign skin tumors with follicular differentiation that present most commonly as solitary lesions. They can also present as multiple centrofacial papules due to several mutations in the CYLD gene. Multiple unilateral trichoepitheliomas in a linear or dermatomal distribution may rarely be seen. Herein, we report a case of multiple unilateral trichoepitheliomas on the face of a healthy 34-year-old woman of Caucasian origin.

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25

Bageshri P, Dr Gogate, and Dr Deshmukh Sanjay D. "Multiple Trichoepitheliomas of Pinna of Ear- A rare case." Indian Journal of Applied Research 4, no. 3 (2011): 321–22. http://dx.doi.org/10.15373/2249555x/mar2014/96.

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26

Monk, B. "(25) Multiple trichoepitheliomas." British Journal of Dermatology 121, s34 (1989): 92. http://dx.doi.org/10.1111/j.1365-2133.1989.tb06001.x.

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27

Clarke, Jennie, Michael Ioffreda, and Klaus F. Helm. "Multiple Familial Trichoepitheliomas." American Journal of Dermatopathology 24, no. 5 (2002): 402–5. http://dx.doi.org/10.1097/00000372-200210000-00005.

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28

DUHRA, P., and J. C. PAUL. "Cryotherapy for Multiple Trichoepithelioma." Journal of Dermatologic Surgery and Oncology 14, no. 12 (1988): 1413–15. http://dx.doi.org/10.1111/j.1524-4725.1988.tb01133.x.

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29

Sood, Samriti, Mudita Gupta, Reena Kumari Sharma, and Manju Rao. "Multiple Non- Familial Trichoepitheliomas in a NineYear Child." Nepal Journal of Dermatology, Venereology & Leprology 17, no. 1 (2019): 76–78. http://dx.doi.org/10.3126/njdvl.v17i1.21119.

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Trichoepitheliomas are rare benign tumours of poorly differentiated trichogenic origin. They present as translucent lesions most commonly on centrofacial regions. Solitary lesions are seen in sporadic cases while multiple lesions are inherited in autosomal dominant pattern. We present a 9 year old child with multiple trichoepitheliomas at classical sites with none of the other family members involved.

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30

Shapiro, P. E. "Familial multiple desmoplastic trichoepitheliomas." Archives of Dermatology 127, no. 1 (1991): 83–87. http://dx.doi.org/10.1001/archderm.127.1.83.

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31

Shapiro, Philip E. "Familial Multiple Desmoplastic Trichoepitheliomas." Archives of Dermatology 127, no. 1 (1991): 83. http://dx.doi.org/10.1001/archderm.1991.01680010093015.

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32

Park, Young Min, Hyung Ok Kim, and Chung Won Kim. "Multiple Trichoepithelioma Associated with Milia." Annals of Dermatology 10, no. 3 (1998): 172. http://dx.doi.org/10.5021/ad.1998.10.3.172.

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33

Durry, Meilany, Anggreiny Iwisara, Fera Mawu, and Sthefanie Gaghana. "Trikoepitelioma Multipel Familial: Laporan Kasus." e-CliniC 11, no. 3 (2023): 352–55. http://dx.doi.org/10.35790/ecl.v11i3.44627.

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Abstract: Trichoepithelioma is a benign tumor of folliculosebaceous-apocrine germ cell origin. There are three clinical variants of trichoepithelioma, as follows: solitary, multiple, and desmoplastic. The clinical features of trichoepithelioma are skin-colored papules up to 0.5 cm in size. with predilection areas on the nose, upper lip, and cheeks. The specific variant of familial multiple trichoepithelioma is inherited in an autosomal-dominant type and usually occurs in childhood and puberty. We reported a 36-year-old woman with complaints of skin-colored papules on the face and neck. There w

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34

Pfaltz, M., and U. W. Schnyder. "Banded structures in multiple familial trichoepithelioma." Acta Dermato-Venereologica 70, no. 2 (1990): 162–64. http://dx.doi.org/10.2340/0001555570162164.

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A case of multiple familial trichoepithelioma was studied by electron microscopy. Tumour cells showed a dilated, rough endoplasmic reticulum (rER), in which banded, electron-dense structures measuring approximately 50 nm in width were found. Some of these banded structures were arranged parallel to each other with an interval of 250 nm.

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35

Hofmann, Lars, Sophie L. Kraus, Birka Brauns, Michael P. Schön, and Lutz Kretschmer. "Komplexe operative Therapie multipler Trichoepitheliome." JDDG: Journal der Deutschen Dermatologischen Gesellschaft 13, no. 5 (2015): 457–60. http://dx.doi.org/10.1111/ddg.12598_suppl.

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36

Rathi, Monika, Seema Awasthi, Satish Kumar Budania, Faiyaz Ahmad, Shyamoli Dutta, and Ashutosh Kumar. "Brooke-Spiegler Syndrome: A Rare Entity." Case Reports in Pathology 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/231895.

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Brooke-Spiegler syndrome is a rare entity. It is an autosomal dominant syndrome in which multiple trichoepitheliomas, cylindromas, or other adnexal tumors are seen. Very few cases of Brooke-Spiegler syndrome are reported in the literature. We came across a 40 -year-old female in which multiple trichoepitheliomas and cylindromas were seen on scalp. In view of clinical history and histopathological examination it was diagnosed as Brooke-Spiegler syndrome. We report this case because of its rarity.

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37

Bakry, OlaA, Iman Seleit, MoshiraM Abdelwahed, RaniaA Hassan, and RehabM Samaka. "Multiple familial trichoepithelioma with malignant transformation." Indian Journal of Dermatology 58, no. 5 (2013): 409. http://dx.doi.org/10.4103/0019-5154.117348.

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38

Rambhia, KinjalD, BhagyashreeB Supekar, SuyashSingh Tomar, and RP Singh. "Multiple familial trichoepithelioma with varied malignancies." Indian Journal of Dermatology 66, no. 2 (2021): 226. http://dx.doi.org/10.4103/ijd.ijd_647_18.

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39

SUMITHRA, SAMBAMURTHY, MURYGAIYA JAYARAMAN, and PATRICK YESUDIAN. "DESMOPLASTIC TRICHOEPITHELIOMA AND MULTIPLE EPIDERMAL CYSTS." International Journal of Dermatology 32, no. 10 (1993): 747–48. http://dx.doi.org/10.1111/j.1365-4362.1993.tb02751.x.

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40

&NA;. "Multiple Trichoepithelioma With Basal Cell Carcinoma." Annals of Plastic Surgery 43, no. 2 (1999): 221–22. http://dx.doi.org/10.1097/00000637-199902000-00027.

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41

&NA;. "Multiple Trichoepithelioma With Basal Cell Carcinoma." Annals of Plastic Surgery 43, no. 2 (1999): 221–22. http://dx.doi.org/10.1097/00000637-199908000-00027.

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42

&NA;. "Multiple Trichoepithelioma With Basal Cell Carcinoma." Annals of Plastic Surgery 43, no. 2 (1999): 221–22. http://dx.doi.org/10.1097/00000637-199943020-00027.

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43

Moon, Seong Hun, Hyun Seok Choi, Hyoung Il Kwon, Joo Yeon Ko, and Jeong Eun Kim. "A Case of Multiple Desmoplastic Trichoepithelioma." Annals of Dermatology 28, no. 3 (2016): 411. http://dx.doi.org/10.5021/ad.2016.28.3.411.

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44

Yang, J. E., K. M. Kim, H. Kang, S. H. Cho, and Y. M. Park. "Multiple trichoepithelioma with secondary localized amyloidosis." British Journal of Dermatology 143, no. 6 (2000): 1343–44. http://dx.doi.org/10.1046/j.1365-2133.2000.03930.x.

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45

SHAFFELBURG, MICHAEL, and ROBERT MILLER. "Treatment of Multiple Trichoepithelioma with Electrosurgery." Dermatologic Surgery 24, no. 10 (1998): 1154–56. http://dx.doi.org/10.1111/j.1524-4725.1998.tb04090.x.

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46

D'Souza, Mariette, Bhagat Ram Garg, Chiganti Ratnakar, and Karoon Agrawal. "Multiple Trichoepitheliomas with Rare Features." Journal of Dermatology 21, no. 8 (1994): 582–85. http://dx.doi.org/10.1111/j.1346-8138.1994.tb01797.x.

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47

Karikal, Arvind, Pushparaj Shetty, Arathi Karikal, and ShishirR Shetty. "Multiple trichoepitheliomas: A rare occurrence." South Asian Journal of Cancer 2, no. 2 (2013): 54. http://dx.doi.org/10.4103/2278-330x.110479.

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48

Prignano, F., M. Mori, M. Wolovsky, and C. Urso. "MULTIPLE TRICHOEPITHELIOMAS AND MALIGNANT ACROSPIROMAS." American Journal of Dermatopathology 16, no. 1 (1994): 101. http://dx.doi.org/10.1097/00000372-199402000-00044.

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49

Capusan, Tania M., Lucero Noguera‐Morel, Elena Bueno‐Martínez, et al. "Multiple familial trichoepitheliomas: Ultrasonographic findings." Skin Research and Technology 26, no. 1 (2019): 137–39. http://dx.doi.org/10.1111/srt.12746.

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50

Rensch, F., B. Harder, M. Goebeler, W. Back, J. B. Jonas, and F. Schlichtenbrede. "Multiple familiäre Trichoepitheliome (Brooke-Syndrom)." Der Ophthalmologe 106, no. 8 (2008): 735–39. http://dx.doi.org/10.1007/s00347-008-1848-2.

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