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Journal articles on the topic 'Tricyclic pyrone'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Perchellet, Elisabeth M., James B. Ladesich, Molly J. Magill, Yi Chen, Duy H. Hua, and Jean-Pierre Perchellet. "Tricyclic pyrone analogs." Anti-Cancer Drugs 10, no. 5 (1999): 489–504. http://dx.doi.org/10.1097/00001813-199906000-00009.

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2

Jin, Lee-Way, Duy H. Hua, Feng-Shiun Shie, Izumi Maezawa, Bryce Sopher, and George M. Martin. "Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death." Journal of Molecular Neuroscience 19, no. 1-2 (2002): 57–61. http://dx.doi.org/10.1007/s12031-002-0011-9.

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3

Hong, Hyun-Seok, Sandeep Rana, Lydia Barrigan, et al. "Inhibition of Alzheimer’s amyloid toxicity with a tricyclic pyrone moleculein vitroandin vivo." Journal of Neurochemistry 108, no. 4 (2009): 1097–108. http://dx.doi.org/10.1111/j.1471-4159.2008.05866.x.

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4

Maezawa, Izumi, Bende Zou, Jacopo Di Lucente та ін. "The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule". Journal of Alzheimer's Disease 58, № 2 (2017): 559–74. http://dx.doi.org/10.3233/jad-161175.

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5

Feng, Li, Jing Han, Jia Wang, et al. "Pestalopyrones A–D, four tricyclic pyrone derivatives from the endophytic fungus Pestalotiopsis neglecta S3." Phytochemistry 179 (November 2020): 112505. http://dx.doi.org/10.1016/j.phytochem.2020.112505.

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6

Chen, Yan, Ge Zou, Wencong Yang, et al. "Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12." Marine Drugs 19, no. 2 (2021): 56. http://dx.doi.org/10.3390/md19020056.

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One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activit

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7

Maezawa, Izumi, Hyun-Seok Hong, Hui-Chuan Wu, et al. "A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes." Journal of Neurochemistry 98, no. 1 (2006): 57–67. http://dx.doi.org/10.1111/j.1471-4159.2006.03862.x.

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8

Trushina, Eugenia, Sandeep Rana, Cynthia T. McMurray, and Duy H. Hua. "Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons." BMC Neuroscience 10, no. 1 (2009): 73. http://dx.doi.org/10.1186/1471-2202-10-73.

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9

Bengtsson, Christoffer, and Fredrik Almqvist. "A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds." Journal of Organic Chemistry 76, no. 23 (2011): 9817–25. http://dx.doi.org/10.1021/jo201952p.

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10

Bengtsson, Christoffer, and Fredrik Almqvist. "ChemInform Abstract: A Selective Intramolecular 5-exo-Dig or 6-endo-Dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds." ChemInform 43, no. 13 (2012): no. http://dx.doi.org/10.1002/chin.201213180.

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11

Perchellet, Elisabeth M., James B. Ladesich, Yi Chen, et al. "Antitumor activity of tricyclic pyrone analogs, a new synthetic class of microtubule de-stabilizing agents, in the murine EMT-6 mammary tumor cell line in vitro." Anti-Cancer Drugs 9, no. 6 (1998): 565–76. http://dx.doi.org/10.1097/00001813-199807000-00008.

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12

Stojakovic, Andrea, Su-Youne Chang, Jarred Nesbitt, et al. "Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice." Journal of Alzheimer's Disease 79, no. 1 (2021): 335–53. http://dx.doi.org/10.3233/jad-201015.

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Background: Accumulation of hyperphosphorylated tau (pTau) protein is associated with synaptic dysfunction in Alzheimer’s disease (AD). We previously demonstrated that neuroprotection in familial mouse models of AD could be achieved by targeting mitochondria complex I (MCI) and activating the adaptive stress response. Efficacy of this strategy on pTau-related pathology remained unknown. Objective: To investigate the effect of specific MCI inhibitor tricyclic pyrone compound CP2 on levels of human pTau, memory function, long term potentiation (LTP), and energy homeostasis in 18-month-old 3xTg-A

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13

Pokhrel, Laxman, Izumi Maezawa, Thi D. T. Nguyen, Kyeong-Ok Chang, Lee-Way Jin та Duy H. Hua. "Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT), Overexpression of Cholesterol Transporter Gene, and Protection of Amyloid β (Aβ) Oligomers-Induced Neuronal Cell Death by Tricyclic Pyrone Molecules". Journal of Medicinal Chemistry 55, № 20 (2012): 8969–73. http://dx.doi.org/10.1021/jm3012189.

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14

Hua, Duy H., Xiaodong Huang, Masafumi Tamura, et al. "Syntheses and bioactivities of tricyclic pyrones." Tetrahedron 59, no. 26 (2003): 4795–803. http://dx.doi.org/10.1016/s0040-4020(03)00687-2.

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15

Mori, Keiji, Nobuaki Umehara, and Takahiko Akiyama. "Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)–H bond functionalization." Chemical Science 9, no. 37 (2018): 7327–31. http://dx.doi.org/10.1039/c8sc02103a.

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16

Leutbecher, Heiko, Sylvia Rieg, Jürgen Conrad, Sabine Mika, Iris Klaiber та Uwe Beifuss. "Synthesis of Phenylsubstituted 2H,5H-Pyrano[ 4,3-b] pyran-5-ones and Related Heterocycles via a Domino Knoevenagel Condensation/ 6π-Electron Electrocyclization of 4-Hydroxy-6-phenyl-2H-pyran-2-one with Cyclic and Acyclic α, β-Unsaturated Aldehydes under Different Conditions Synthesis and Crystal Structure of the High-pressure Iron Borate β-FeB2O4 Synthesis and Crystal Structure of the High-pressure Iron Borate β-FeB2O4 Synthesis and Crystal Structure of the High-pressure Iron Borate β-FeB2O4 Synthesis and Crystal Structure of the High-pressure Iron Borate β-FeB2O4 Synthesis and Crystal Structure of the High-pressure Iron Borate β-FeB2O4". Zeitschrift für Naturforschung B 64, № 8 (2009): 1–10. http://dx.doi.org/10.1515/znb-2009-0801.

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A range of new 7-phenyl-2H,5H-pyrano[4,3-b]pyran-5-ones and related tricyclic heterocycles was prepared in a single step by means of a domino Knoevenagel condensation/6π-electron electrocyclization under different reaction conditions, including thermal and microwave conditions. The influence of several ionic liquids as solvents was also studied

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17

Marchalín, Štefan, Františka Pavlíková, and Dušan Ilavský. "Synthesis and spectral properties of pyrrolo[3',4':5,6]-4H-pyrano[2,3-d]pyrimidine derivatives." Collection of Czechoslovak Chemical Communications 54, no. 5 (1989): 1336–45. http://dx.doi.org/10.1135/cccc19891336.

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The starting 2-amino-5-ethoxycarbonyl-6-chloromethyl-4-(2-furyl)-3-cyano-4H-pyran (I) afforded on condensation with triethoxymethane 2-ethoxymethylenamino-4H-pyran II; treatment of the latter with ammonia yielded 2-formamidino-3-cyano-4H-pyran III, which, when heated in dilute ethanol, cyclized to 4-amino-6-ethoxycarbonyl-5-(2-furyl)-7-chloromethyl-4H-pyrano[2,3-d]pyrimidine (IV). Compound IV reacted with alkyl- or arylamines to give substituted 5H,6H,8H-pyrrolo[3',4':5,6]-4H-pyrano[2,3-d]pyrimidines VI, one of which (VIb, R = p-CH3C6H4) was alternatively obtained from 2-formamidino-4H-pyrano

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18

Habashneh, Almeqdad Y., Mustafa M. El-Abadelah, Mohammad S. Mubarak, and Wolfgang Voelter. "Heterocycles [f]-Fused onto Quinolones. Synthesis of Novel Dioxo-Nethylpyrano[ 2,3-f ]- and [3,2-f ]quinoline-10-carboxylic Acids." Zeitschrift für Naturforschung B 68, no. 9 (2013): 1049–55. http://dx.doi.org/10.5560/znb.2013-3122.

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A model N-ethyl-1,10-dioxo-3-phenylpyrano[3,2- f ]quinoline-9-carboxylic acid (8) and the isomeric (2-substituted) pyrano[2,3- f ]quinoline-9-carboxylic acids (6 and 7) were prepared from the corresponding 6/7-aminochromen-4-ones via the Gould-Jacobs reaction. The new tricyclic heterocycles 6-8 exhibit moderate antibacterial activity (MIC=16 - 64 μgmL-1) against E. coli and S. aureus

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19

Mukherjee, Prasun, Sanjay Paul, and Asish R. Das. "Expeditious synthesis of functionalized tricyclic 4-spiro pyrano[2,3-c]pyrazoles in aqueous medium using dodecylbenzenesulphonic acid as a Brønsted acid–surfactant-combined catalyst." New Journal of Chemistry 39, no. 12 (2015): 9480–86. http://dx.doi.org/10.1039/c5nj01728a.

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20

Bisagni, Emile, Catherine Jolivet, and Christian Rivalle. "Synthesis of Pyrano[2,3-h]quinolines as Tricyclic Acronycine Analogues." HETEROCYCLES 43, no. 5 (1996): 995. http://dx.doi.org/10.3987/com-95-7384.

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21

Mamedov, Ibrahim G., Victor N. Khrustalev, Pavel V. Dorovatovskii, Farid N. Naghiev, and Abel M. Maharramov. "Efficient synthesis of new tricyclic pyrano[3,2-c]pyridine derivatives." Mendeleev Communications 29, no. 2 (2019): 232–33. http://dx.doi.org/10.1016/j.mencom.2019.03.040.

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22

Konda, Saidulu, Pallavi Rao, and Srinivas Oruganti. "Click chemistry route to tricyclic monosaccharide triazole hybrids: design and synthesis of substituted hexahydro-4H-pyrano[2,3-f][1,2,3]triazolo[5,1-c][1,4]oxazepines." RSC Adv. 4, no. 109 (2014): 63962–65. http://dx.doi.org/10.1039/c4ra11035h.

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23

Chen, Chien-Hsing, and Chun-Chen Liao. "One-Pot Stereoselective Synthesis of Tricyclic Bislactones from 2-Pyrones and 2-Methoxyfuran." Organic Letters 2, no. 14 (2000): 2049–52. http://dx.doi.org/10.1021/ol000082w.

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24

Lu, Xue, Yili Zhang, Yichen Wang, et al. "Asymmetric Catalysis Using Modularly Designed Organocatalysts: Synthesis of Fused Tricyclic Pyrano‐Pyrano[2,3‐ c ]pyrrol Derivatives." Advanced Synthesis & Catalysis 361, no. 13 (2019): 3234–38. http://dx.doi.org/10.1002/adsc.201900254.

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25

Shearer, Charles, Oriane Desaunay, Stephen Zorc, et al. "Intercepted-Knoevenagel condensation for the synthesis of unsymmetrical fused-tricyclic 4H-pyrans." Tetrahedron 75, no. 43 (2019): 130606. http://dx.doi.org/10.1016/j.tet.2019.130606.

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26

JOLIVET, C., C. RIVALLE, and E. BISAGNI. "ChemInform Abstract: Synthesis of Pyrano(2,3-h)quinolines as Tricyclic Acronycine Analogues." ChemInform 27, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199638159.

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27

Chen, Chien-Hsing, and Chun-Chen Liao. "ChemInform Abstract: One-Pot Stereoselective Synthesis of Tricyclic Bislactones from 2-Pyrones and 2-Methoxyfuran." ChemInform 31, no. 42 (2000): no. http://dx.doi.org/10.1002/chin.200042039.

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28

Goswami, Shyamaprosad, and Avijit Kumar Adak. "A novel one-pot two-component synthesis of tricyclic pyrano[2,3-b]quinoxalines." Tetrahedron Letters 46, no. 2 (2005): 221–24. http://dx.doi.org/10.1016/j.tetlet.2004.11.084.

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29

Rana, Sandeep, Hyun-Seok Hong, Lydia Barrigan, Lee-Way Jin та Duy H. Hua. "Syntheses of tricyclic pyrones and pyridinones and protection of Aβ-peptide induced MC65 neuronal cell death". Bioorganic & Medicinal Chemistry Letters 19, № 3 (2009): 670–74. http://dx.doi.org/10.1016/j.bmcl.2008.12.060.

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30

Wei, Jia, Wenjun Gui, Yanjun Cui, Zhifang Zhang, and Qahtan A. Yousif. "SCMNPs@Uridine/Zn: An efficient and reusable heterogeneous nanocatalyst for the rapid one-pot synthesis of tricyclic fused pyrazolopyranopyrimidine and 3-methyl carboxylate substituted pyrano[2,3-c]pyrazole derivatives under solvent-free conditions." Polish Journal of Chemical Technology 22, no. 2 (2020): 20–33. http://dx.doi.org/10.2478/pjct-2020-0013.

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AbstractSCMNPs@Uridine/Zn is utilized as an environmental-friendly and efficient heterogeneous nanocatalyst for two one-pot four-component condensation reactions, containing hydrazine hydrate, arylaldehyde, ethyl acetoacetate, and barbituric acid to yield tricyclic fused pyrazolopyranopyrimidine derivatives (5a-q), and hydrazine hydrate, arylaldehyde, malononitrile, and dimethyl acetylenedicarboxylate/diethyl acetylenedicarboxylate to yield 3-methyl carboxylate substituted pyrano[2,3-c]pyrazole derivatives (8a-y) under solvent-free conditions with high to excellent yields. The main advantages

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31

Mohammed, Hamdoon A., Lalla A. Ba, Torsten Burkholz, et al. "Facile Synthesis of Chrysin-derivatives with Promising Activities as Aromatase Inhibitors†." Natural Product Communications 6, no. 1 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600108.

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Flavones such as chrysin show structural similarities to androgens, the substrates of human aromatase, which converts androgens to estrogens. Aromatase is a key target in the treatment of hormone-dependent tumors, including breast cancer. Flavone-based aromatase inhibitors are of growing interest, and chrysin in particular provides a (natural) lead structure. This paper reports multicomponent synthesis as a means for facile modification of the chrysin core structure in order to add functional elements. A Mannich-type reaction was used to synthesize a range of mono- and disubstituted chrysin de

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32

Gimazetdinov, Airat M., Vladimir V. Loza, Leonid V. Spirikhin, Aidar Z. Al’mukhametov, and Mansur S. Miftakhov. "Hydroxy-directed Prins cyclizations. Synthesis of the bowl-type chiral tricyclic cyclopentanoids, bicyclic pyranes, and furanes." Tetrahedron: Asymmetry 26, no. 12-13 (2015): 608–12. http://dx.doi.org/10.1016/j.tetasy.2015.04.014.

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33

Shi, Li-Min, Wu-Wei Dong, Hai-Yan Tao, Xiu-Qin Dong, and Chun-Jiang Wang. "Catalytic Asymmetric Desymmetrization of Cyclopentendiones via Diels–Alder Reaction of 3-Hydroxy-2-pyrones: Construction of Multifunctional Bridged Tricyclic Lactones." Organic Letters 19, no. 17 (2017): 4532–35. http://dx.doi.org/10.1021/acs.orglett.7b02107.

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34

Kolaříková, Viola, Markéta Rybáčková, Martin Svoboda, and Jaroslav Kvíčala. "Ring-closing metathesis of prochiral oxaenediynes to racemic 4-alkenyl-2-alkynyl-3,6-dihydro-2H-pyrans." Beilstein Journal of Organic Chemistry 16 (November 13, 2020): 2757–68. http://dx.doi.org/10.3762/bjoc.16.226.

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The prochiral 4-(allyloxy)hepta-1,6-diynes, optionally modified in the positions 1 and 7 with an alkyl or ester group, undergo a chemoselective ring-closing enyne metathesis yielding racemic 4-alkenyl-2-alkynyl-3,6-dihydro-2H-pyrans. Among the catalysts tested, Grubbs 1st generation precatalyst in the presence of ethene (Mori conditions) gave superior results compared to the more stable Grubbs or Hoveyda–Grubbs 2nd generation precatalysts. This is probably caused by a suppression of the subsequent side-reactions of the enyne metathesis product with ethene. On the other hand, the 2nd generation

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35

Parmar, Bhagyashri D., Tushar R. Sutariya, Gaurangkumar C. Brahmbhatt, Narsidas J. Parmar, Rajni Kant, and Vivek K. Gupta. "A Base-Catalyzed, Domino Aldol/hetero-Diels–Alder Synthesis of Tricyclic Pyrano[3,4-c]chromenes in Glycerol." Journal of Organic Chemistry 81, no. 12 (2016): 4955–64. http://dx.doi.org/10.1021/acs.joc.6b00107.

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36

Melani, Fabrizio, Lucia Cecchi, Vittoria Colotta, Giovanna Palazzino, and Guido Filacchioni. "Tricyclic heterocyclic systems: Pyrazolo[5′,4′:4,5]-and pyrazolo-[3′,4′:4,5]pyrano[2,3-b]pyridine derivatives." Journal of Heterocyclic Chemistry 25, no. 5 (1988): 1367–71. http://dx.doi.org/10.1002/jhet.5570250518.

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37

Jacoby, George A., Marian A. Corcoran, and David C. Hooper. "Protective Effect of Qnr on Agents Other than Quinolones That Target DNA Gyrase." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 6689–95. http://dx.doi.org/10.1128/aac.01292-15.

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ABSTRACTQnr is a plasmid-encoded and chromosomally determined protein that protects DNA gyrase and topoisomerase IV from inhibition by quinolones. Despite its prevalence worldwide and existence prior to the discovery of quinolones, its native function is not known. Other synthetic compounds and natural products also target bacterial topoisomerases. A number were studied as molecular probes to gain insight into how Qnr acts. Qnr blocked inhibition by synthetic compounds with somewhat quinolone-like structure that target the GyrA subunit, such as the 2-pyridone ABT-719, the quinazoline-2,4-dione

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38

Rahman, Anisur, J. A. Barrowman, and A. Rahimtula. "The influence of bile on the bioavailability of polynuclear aromatic hydrocarbons from the rat intestine." Canadian Journal of Physiology and Pharmacology 64, no. 9 (1986): 1214–18. http://dx.doi.org/10.1139/y86-205.

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The mechanisms governing absorption of polynuclear aromatic hydrocarbons (PAHs) are important since these carcinogenic compounds occur as solutes in dietary lipids. These highly lipophilic compounds are well absorbed in the intestine. Bile salt micellar solubilization probably facilitates their transport across the unstirred water layer to the enterocytes. To study the role of bile in the intestinal absorption of PAHs, conscious rats with bile duct and duodenal catheters were given isotopically labelled 2,6-dimethylnaphthalene (DMN), phenanthrene, anthracene, 7,12-dimethylbenzanthracene (DMBA)

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39

Inoue, Seiichi, Riyoung Kim, Yujiro Hoshino, and Kiyoshi Honda. "Synthesis of tricyclic pyrano[2,3-e]isoindolin-3-ones as the core structure of stachybotrin A, B, and C." Chemical Communications, no. 18 (2006): 1974. http://dx.doi.org/10.1039/b601433j.

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40

Rigante, Donato, and Raffaele Manna. "FAMILIAL MEDITERRANEAN FEVER: ASSESSING THE OVERALL CLINICAL IMPACT AND FORMULATING TREATMENT PLANS." Mediterranean Journal of Hematology and Infectious Diseases 11, no. 1 (2019): e2019027. http://dx.doi.org/10.4084/mjhid.2019.027.

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Recurrent self-limited attacks of fever and short-lived inflammation in the serosal membranes, joints and skin are the leading features of familial Mediterranean fever (FMF), the most common autoinflammatory disorder in the world, transmitted as autosomal recessive trait caused by MEFV gene mutations. Their consequence is an abnormal function of pyrin, a natural repressor of inflammation, apoptosis and release of cytokines. FMF-related mutant pyrins are hypophosphorylated following RhoA GTPases’ impaired activity and show a propensity to relapsing uncontrolled systemic inflammation with inappr

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41

Nakahama, Kenta, Misato Suzuki, Mami Ozako, Isao Mizota та Makoto Shimizu. "One‐pot Syntheses of 3‐Amino‐2‐pyrones and 3‐Amino‐5,6‐dihydro‐2‐pyridones from β,γ‐Unsaturated α‐Iminoesters: Application to the Synthesis of A Tricyclic Pyranoindole". Asian Journal of Organic Chemistry 7, № 5 (2018): 910–13. http://dx.doi.org/10.1002/ajoc.201800186.

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42

Abdel-Rahman, Adel A. H., Amira K. F. Shaban, Ibrahim F. Nassar, et al. "Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity." Molecules 26, no. 13 (2021): 3923. http://dx.doi.org/10.3390/molecules26133923.

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New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylamino derivatives were prepared to obtain the pyridine-‑C2 functionalized derivatives. The derived pyrazolpyridine-N-glycosides were synthesized via heterocyclization of the C2-thioxopyridine derivative followed by glycosylation using glucose and galactose. The furopyridine derivative 14 and the tricy

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43

Gerspacher, Marc, Robin A. Fairhurst, Robert Mah та ін. "Discovery of a novel tricyclic 4H-thiazolo[5′,4′:4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity". Bioorganic & Medicinal Chemistry Letters 25, № 17 (2015): 3582–84. http://dx.doi.org/10.1016/j.bmcl.2015.06.077.

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44

Rodgman, A., and CR Green. "Toxic Chemicals in Cigarette Mainstream Smoke - Hazard and Hoopla." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 20, no. 8 (2003): 481–545. http://dx.doi.org/10.2478/cttr-2013-0764.

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AbstractThese are curious times. The Canadian government has passed legislation that requires cigarette manufacturers to routinely test and publish the amounts of 44 toxic substances in cigarette mainstream smoke (MSS). Following in the footsteps of their northern neighbor, various US legislators and regulators are considering modifications to their cigarette testing and reporting programs that will also list toxicants in MSS. Across the Atlantic Ocean, the European Commission has passed a directive that may also follow the North American lead for public disclosure of MSS toxic chemicals for e

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45

Newell, S. W., E. M. Perchellet, J. B. Ladesich, et al. "Tricyclic pyrone analogs: a new class of microtubule-disrupting anticancer drugs effective against murine leukemia cells in vitro." International Journal of Oncology, February 1, 1998. http://dx.doi.org/10.3892/ijo.12.2.433.

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46

Wójcicka, Anna. "Synthesis and Biological Activity of 2,7-Naphthyridine Derivatives: An Overview." Current Organic Chemistry 25 (August 12, 2021). http://dx.doi.org/10.2174/1385272825666210812102815.

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: 2,7-Naphthyridine is one of the six structural isomers of pyridopyridine. Biological investigations have shown that these compounds have a broad spectrum of activity. They have been found to have antitumor, antimicrobial, analgesic and anticonvulsant effects. The broad spectrum of biological activity of 2,7-naphthyridine derivatives is the main reason for the preparation of new compounds containing this scaffold. This review aims to present various methods of obtaining 2,7-naphthyridine analogs. Compounds containing a 2,7-naphthyridine moiety can be synthesized from a variety of substrates a

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47

MELANI, F., L. CECCHI, V. COLOTTA, G. PALAZZINO, and G. FILACCHIONI. "ChemInform Abstract: Tricyclic Heterocyclic Systems: Pyrazolo(5′,4′:4,5)((3′,4′:4,5))pyrano-(2,3-b)pyridine Derivatives." ChemInform 20, no. 27 (1989). http://dx.doi.org/10.1002/chin.198927199.

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BALBI, A., G. ROMA, M. MAZZEI, E. SOTTOFATTORI, S. CADEL, and P. SCHIANTARELLI. "ChemInform Abstract: Chemical and Pharmacological Studies on Pyrane Derivatives. Part 18. Synthesis of Substituted 2-(Dialkylamino)-3-formylchromones and Their Tricyclic Derivatives." ChemInform 21, no. 7 (1990). http://dx.doi.org/10.1002/chin.199007212.

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Parmar, Bhagyashri D., Tushar R. Sutariya, Gaurangkumar C. Brahmbhatt, Narsidas J. Parmar, Rajni Kant, and Vivek K. Gupta. "ChemInform Abstract: A Base-Catalyzed, Domino Aldol/Hetero-Diels-Alder Synthesis of Tricyclic Pyrano[3,4-c]chromenes in Glycerol." ChemInform 47, no. 44 (2016). http://dx.doi.org/10.1002/chin.201644128.

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Inoue, Seiichi, Riyoung Kim, Yujiro Hoshino, and Kiyoshi Honda. "Synthesis of Tricyclic Pyrano[2,3-e]isoindolin-3-ones as the Core Structure of Stachybotrin A, B, and C." ChemInform 37, no. 37 (2006). http://dx.doi.org/10.1002/chin.200637172.

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