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Journal articles on the topic 'Trifluoro Acetic Acid'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gupta, Ritesh Kant, Rabindranath Garai, and Parameswar Krishnan Iyer. "Ambient Stable Perovskite Solar Cells through Trifluoro Acetic Acid-Mediated Multifunctional Anchoring." ACS Applied Energy Materials 5, no. 2 (2022): 1571–79. http://dx.doi.org/10.1021/acsaem.1c02984.

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2

PADMINI, THATAVARTHI, and BIGALA RAJ KAMAL. "Synthesis, Anti-inflammatory, Analgesic and Antipyretic Activity of Novel 1,3,5-Trisubstituted Pyrazole Derivatives." Asian Journal of Chemistry 31, no. 6 (2019): 1225–29. http://dx.doi.org/10.14233/ajchem.2019.21781.

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A novel series of 1,3,5-trisubstituted pyrazole derivatives were synthesized by the cycloaddition reaction between the electron rich N-substituted aryl hydrazones and nitro-olefins. Different N-substituted aryl hydrazones (1a-j) on reacting with 4-methyl-β-nitrostyrene (2) in ethylene glycol or trifluoroethanol-trifluoro acetic acid mixture (for acid stable hydrazones) at 120 ºC, yielded various 1,3,5-trisubstituted pyrazoles (3a-j). The final products were characterized by spectral analysis using Mass, NMR and IR spectroscopy. All the products were assessed for their anti-inflammatory, analge

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3

Schenk, Wolfdieter A., Nikola Sonnhalter, and Nicolai Burzlaff. "Synthesis of Cationic Ruthenium Thioketene Complexes through Intramolecular 1,2-Elimination [1]." Zeitschrift für Naturforschung B 52, no. 1 (1997): 117–24. http://dx.doi.org/10.1515/znb-1997-0123.

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Halfsandwich thiocarboxylate complexes [CpRu(PR3)2(SC(O)CH2R′)] ((PR3)2 = (PPh3)2, Ph2PCH2PPh2 (dppm), Ph2PC2H4PPh2 (dppe); R′ = C6H5, 4-C6H4Me, 4-C6H4OMe, 4-C6H4Cl) are obtained from the corresponding thiolate complexes [CpRu(PR3)2SH] and acyl chlorides. The structure of [CpRu(dppm)(SC(O)CH2Ph)] was determined: monoclinic space group P21/c (No. 14), a = 9.229(2), b = 16.680(3), c = 21.447(5) Å, β = 90.751(12)°, Z = 4. Reaction of the thiocarboxylate complexes with the anhydrides of either trifluoro-acetic acid or trifluoromethanesulfonic acid gives thioketene complexes [CpRu(dppm) (η2-S=C=CHR

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4

Benzil, Dudekula1* Dr.C.Ramachandraiah2 Dr.N.Devanna3. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR DRUG PRODUCT BY RP-HPLC METHOD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 480–87. https://doi.org/10.5281/zenodo.1036476.

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Analytical method was developed for the estimation of Sofosbuvir and Daclatasvir drug substance by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Acetonitrile (60:40). The flow rate was 1.0 ml/ minute and ultra violet detector at 275nm. The average retention time for Sofosbuvir and Daclatasvir found to be 2.09 and 3.50 min. The proposed method was validated for selectivity, precision, linearity and accuracy. Al

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5

Uppalapati.Jyothi*1, Dr.Parimi.Umadevi2. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR DRUG PRODUCT BY RP-HPLC METHOD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 401–9. https://doi.org/10.5281/zenodo.1036448.

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A novel reversed phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of Sofosbuvir and Velpatasvir drug product by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Methanol (42:58). The flow rate was 1.0 ml/ minute and ultra violet detector at 269nm. The average retention time for Sofosbuvir and Velpatasvir found to be 3.44 and 4.68 min. The proposed method was vali

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6

Balasekaran, Samundeeswari Mariappan, Adelheid Hagenbach, and Frederic Poineau. "Towards mid-valent rhenium fluoro-phosphine complexes via hexafluoridorhenate(IV) anion pathway assisted by trifluoro acetic acid." Inorganic Chemistry Communications 119 (September 2020): 108064. http://dx.doi.org/10.1016/j.inoche.2020.108064.

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7

Talybov, Gulahmad, Aygun Baghirli та Najiba Shirinova. "SYNTHESIS AND DETERMINATION OF THE ABSOLUTE CONFIGURATION OF MONOETHERS OF α-GLYCOLS OF ALLYL AND PROPARGYL ALCOHOLS BY NMR 1H SPECTROSCOPY". Ukrainian Chemistry Journal 86, № 4 (2020): 126–31. http://dx.doi.org/10.33609/2708-129x.86.4.2020.126-131.

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The synthesis of previously unknown unsaturated aromatic oxyethers was carried out by reaction of chloromethylpropargyl(allyl) ether with phenacyl bromide, with the participation of the chiral catalyst - (+)-benzotetramisole, and their configurations were also established. It was shown the anisotropic effect of the phenyl group in the acid chloride of α-methoxytrifluoromethylphenylacetic acid (MTPA-Cl) on the halogenaryl group. Such effect leads to screening of the latter, and this, in turn, leads to a shift to a strong field and positive values of ∆δR/S, while proton signals of the less bulky

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8

Hřebabecký, Hubert, Martin Dračínský, and Antonín Holý. "Synthesis of Novel Carbocyclic Nucleoside Analogues Containing Bicyclo[2.2.1]hept-2-ene-2-methanol." Collection of Czechoslovak Chemical Communications 73, no. 1 (2008): 44–58. http://dx.doi.org/10.1135/cccc20080044.

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Starting ethyl (1R*,2R*,3R*,4S*)-3-bromobicyclo[2.2.1]hept-5-ene-2-carboxylate (9) was reduced with LiAlH4and benzoylated giving [(1R*,2R*,3R*,4S*)-3-bromobicyclo[2.2.1]hept-5-en-2-yl]methyl benzoate (11). Treatment of11with NaN3and CrO3in acetic acid afforded [(1R*,2S*,3R*,4R*,5S*,6R*)-6-azido-3-bromo-5-hydroxybicyclo[2.2.1]hept-2-yl]methyl benzoate (12a) and [(1R*,2S*,3S*,4R*,5S*,6R*)-5-azido-3-bromo-6-hydroxybicyclo[2.2.1]heptan-2-yl]-methyl benzoate (12b). These key intermediates were separated and converted in five reaction steps to (1R*,2R*,3S*,4S*)-3-[(5-amino-6-chloropyrimidin-4-yl)ami

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9

D.T., Biradar, and M. B. Swami Dr. "Synthesis of Schiff's Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes." International Journal of Current Science Research and Review 04, no. 07 (2021): 677–83. https://doi.org/10.47191/ijcsrr/V4-i7-09.

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Abstract : Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported for one-pot multi component cyclo-condensation of an alkayane urea / Thiourea and Aldehyde to 2- amino-4H-1, 3-Oxazines or Thiazines. Different catalysts are reported like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal and Co-workers have utilized perchloric acid (HClO4) supported on silica gel as catalyst under solvent free condition ytterbium trifluorate [Yb(OTF)3] plays role of Lewis acid. It is also used in several Diel’s-Alder cyclo-add

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10

Raval, Milin. "QUALITATIVE AND QUANTITATIVE ASSESSMENT OF RELATED SUBSTANCES IN THE CLOBETASOL PROPIONATE IN TOPICAL CREAM DOSAGE FORM BY RP-HPLC." Journal of Medical pharmaceutical and allied sciences 10, no. 6 (2021): 4072–4. http://dx.doi.org/10.22270/jmpas.v10i6.1838.

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The identification and control of impurities in drug substance and drug product is considered as very critical factor by regulatory agency for safe and effective use of Drug product for its intended use. A specific and sensitive Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method is developed and validated for the estimation of 11 specified impurities in Topical Clobetasol Propionate Cream. The chromatographic parameters for develop method are C18 column, proportion of Water: Methanol: Acetonitrile: Trifluoro acetic acid as mobile phase at flow rate of 1.2 ml/min and UV detec

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11

Seal, Tapan, Kausik Chaudhuri, and Basundhara Pillai. "Chromatographic Estimation of Water Soluble Vitamins in Wild Edible Plants." Asian Journal of Chemistry 33, no. 11 (2021): 2845–50. http://dx.doi.org/10.14233/ajchem.2021.23452.

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A reversed-phase high performance liquid chromatographic technique has been developed for the simultaneous quantitation of water soluble vitamins in 10 potent wild edible plants consumed by the tribal people of North-eastern region in India. The chromatographic separations of vitamins were assessed on Acclaim C18 column using a mobile phase of acetonitrile and aqueous trifluoro acetic acid solution with gradient elution. The experimental results exhibited that for different plants, the vitamin C content ranged between 0.15 ± 0.003 to 8.10 ± 0.03 mg/100g dry plant material (DPM). The vitamin B2

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12

Yahyazadeh, Mahdi, Dirk Selmar, and Gerold Jerz. "Electrospray–Mass Spectrometry-Guided Targeted Isolation of Indole Alkaloids from Leaves of Catharanthus roseus by Using High-Performance Countercurrent Chromatography." Molecules 30, no. 10 (2025): 2115. https://doi.org/10.3390/molecules30102115.

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Electrospray mass spectrometry off-line profiling monitored the recovery of targeted indole alkaloids from a fortified crude extract of Catharanthus roseus (790 mg) using semi-preparative high-performance countercurrent chromatography (HPCCC) fractionation. Visualization of selected single-ion traces projected the HPCCC molecular weight elution profile. Experimental partition-ratio values KD and peak widths for detected metabolites were determined. Structural characterization of metabolites and co-elution effects were monitored in the scan range m/z 100–2000. In this study, the biphasic solven

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13

Nimmagadda, Rajya L., and Sowjanya Gummadi. "Concurrent Estimation of a Three Combination Type-2 Anti-diabetic Oral Dosage Form by Ultra-performance Liquid Chromatography." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 04 (2023): 1171–77. http://dx.doi.org/10.25258/ijpqa.14.4.53.

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Estimation of a three-combination dosage form containing metformin (MET), vildagliptin (VLDG), and remogliflozin etabonate (REMET) was performed by developing an economically simple and isocratic simultaneous method using ultra-performance liquid chromatograph (Alliance 1100 series) comprising of X-Bridge (50 × 4.6 mm, 2.5 μ) C18 column and photo diode array detector. 0.1 % v/v trifluoro acetic acid: acetonitrile (60:40% v/v) movable phase at 0.5 mL/min was used. The analytes were detected at a wavelength of 240.0 nm at 8.0 min. run time. The respective retention times of 1.004, 2.005, 5.118 m

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14

Shobha, D., M. Adharvana Chari, and K. H. Ahn. "An efficient Biginelli one-pot synthesis of new benzoxazole-substituted dihydropyrimidinones and thiones catalysed by trifluoro acetic acid under solvent-free conditions." Chinese Chemical Letters 20, no. 9 (2009): 1059–61. http://dx.doi.org/10.1016/j.cclet.2009.03.024.

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15

Smpokou, Evangelia-Theano, Marvin González-Quiroz, Carla Martins, et al. "Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy." Occupational and Environmental Medicine 76, no. 12 (2019): 920–26. http://dx.doi.org/10.1136/oemed-2019-105772.

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ObjectivesThere is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case–control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years.MethodsUrine sam

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16

Carloni, Patricia, Elisabetta Damiani, Lucedio Greci, et al. "Oxidative dimerization of quinolinic nitroxides in the presence of trichloro- and trifluoro- acetic acid. Crystal structures of 6,6′-bis-(1-oxide-1,2,6,8a-tetrahydroquinoline)ylidene and of 2,3-diphenylquinoline." Tetrahedron 49, no. 23 (1993): 5099–108. http://dx.doi.org/10.1016/s0040-4020(01)81875-5.

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17

Murali Krishna, Mantripragada V. V. N., Sumathi Vinay Rao, and Nutulapati V. S. Venugopal. "Forced Degradation Study for Tenofovir DF, Lamivudine and Efavirenz in Triple Combination Anti-Retroviral Tablets and Development of Validated Stability Indicating Assay Method by UPLC." Current Pharmaceutical Analysis 15, no. 1 (2018): 82–94. http://dx.doi.org/10.2174/1573412913666171120163959.

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Introduction: Tenofovir Disoproxil Fumarate/Lamivudine/Efavirenz Tablets are a pharmaceutical dosage form indicated for the treatment of Human Immunodeficiency Virus (HIV) infection. Methods: A simple, time efficient and stability indicating Reverse Phase Ultra Performance Liquid Chromatography (RP – UPLC) method was developed for the simultaneous determination of the three drugs present in the tablets. Mobile phase-A is 0.1% Trifluoro Acetic acid in water and mobile phase-B is acetonitrile in gradient elution mode. Flow rate at 0.4 mL/min was fixed in the method. Acquity BEH Phenyl (100 mm ×

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18

Pinjari, M. Jakir S. K., Rahul S. Somani, and Ritu M. Gilhotra. "A RAPID, SENSITIVE AND VALIDATED ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY AND TANDEM MASS SPECTROMETRY METHOD FOR DETERMINATION OF PAROMOMYCIN IN MICE PLASMA: APPLICATION TO PHARMACOKINETIC STUDY." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 5 (2017): 86. http://dx.doi.org/10.22159/ijpps.2017v9i5.11024.

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Objective: To develop and validate simple, sensitive, accurate and selective UPLC-MS/MS method for quantification of paromomycin (PARO) in mice plasma.Methods: Precipitation method was used for the extraction of plasma samples, an aliquot of 25 µl plasma samples was extracted using 10% perchloric acid in water. Chromatographic separation was performed using waters acquity ultra-performance liquid chromatography (UPLC) columns, BEH HILIC (50 mm× 2.1 mm, 1.7 µm) by a gradient mixture of acetonitrile and water (both containing 0.005% v/v trifluro acetic acid) as a mobile phase at the flow rate of

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19

S., Naazneen* A. Sridevi. "DEVELOPMENT OF ASSAY METHOD AND FORCED DEGRADATION STUDY OF LEDIPASVIR AND SOFOSBUVIR BY RP-HPLC IN TABLET FORMULATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 480–89. https://doi.org/10.5281/zenodo.1036335.

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Chronic hepatitis C virus (HCV) infection is one of the most common etiologies of liver-related mortality throughout the world. Sofosbuvir and ledipasvir are inhobits HCV NS5B and HCV NS5A polymerase respectively. No published LC-MS/MS and HPLC based methods for simultaneous estimation of ledipasvir and sofosbuvir. Therefore, A stability indicating high performance liquid Chromatographic (HPLC) method was developed and validated for estimation of both drugs. Chromatographic separation was achieved on a C18 column [Xterra, 250 x 4.6 mm, 5μ] utilizing a mobile phase consisting a mixture of 0.1%

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20

Podwyszyńska, Małgorzata, Eleonora Gabryszewska, and Andrzej Przybyła. "Effect of growth retardants, cytokinins and auxins on the multiplication and rooting in vitro of Alstroemeria x hybrida "Juanita"." Acta Agrobotanica 51, no. 1-2 (2013): 23–31. http://dx.doi.org/10.5586/aa.1998.003.

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Rhizome cultures of "Jiianita" Polish cultivar of Alstroemeria x hybrida were used to enhance an effectiveness of micropropagation method of new cultivars and selections. The effect of cytokinins (BAP. kinetin and 2iP), auxins (IAA, IBAand NAA), growth retardants (paclobutrazol and flurprimidol alone or in combination were studied in relation to rhizome branching. aerial shoot production and rooting of rhizome. The greatest number of aerial shoots as well as the shortest shoots were observed at the highest BAP concentration (6 mg l<sup>-1</sup>). However, the rhizonies had the poor

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21

Van Zandt, Michael C., Brian Doan, Diane R. Sawicki, Janet Sredy, and Alberto D. Podjarny. "Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications." Bioorganic & Medicinal Chemistry Letters 19, no. 7 (2009): 2006–8. http://dx.doi.org/10.1016/j.bmcl.2009.02.037.

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22

Plackett, E., C. Robertson, A. De Matos Loja, et al. "Structural dynamics around a hydrogen bond: Investigating the effect of hydrogen bond strengths on the excited state dynamics of carboxylic acid dimers." Journal of Chemical Physics 160, no. 12 (2024). http://dx.doi.org/10.1063/5.0192407.

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The photochemical dynamics of the acetic acid and trifluoro-acetic acid dimers in hexane are studied using time-resolved infrared absorption spectroscopy and ab initio electronic structure calculations. The different hydrogen bond strengths of the two systems lead to changes in the character of the accessed excited states and in the timescales of the initial structural rearrangement that define the early time dynamics following UV excitation. The much stronger hydrogen bonding in the acetic acid dimer stabilizes the system against dissociation. Ground state recovery is mediated by a structural

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23

Shablykin, Oleh V., Volodymyr S. Brovarets, and Olga V. Shablykina. "Recyclization of 5‐Amino‐ oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)." Chemical Record, October 26, 2023. http://dx.doi.org/10.1002/tcr.202300264.

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AbstractThe recyclizations of 5‐amino‐ and 5‐hydrazine‐1,3‐oxazoles mainly with electron‐withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α‐aminoazoles. 5‐Amino/hydrazine‐1,3‐oxazoles undergo recyclization both in nucleophilic (amines, hydrazine, thionating agents) and electrop

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24

Benzil, Dudekula1* Dr.C.Ramachandraiah2 Dr.N.Devanna3. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR DRUG PRODUCT BY RP-HPLC METHOD." August 31, 2017. https://doi.org/10.5281/zenodo.2526789.

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Analytical method was developed for the estimation of Sofosbuvir and Daclatasvir drug substance by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Acetonitrile (60:40). The flow rate was 1.0 ml/ minute and ultra violet detector at 275nm. The average retention time for Sofosbuvir and Daclatasvir found to be 2.09 and 3.50 min. The proposed method was validated for selectivity, precision, linearity and accuracy. Al

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25

B.Sowjanya1*, Dr.K.Rambabu2. "DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LAMIVUDINE AND DOLUTEGRAVIR IN DRUG PRODUCT BY RP-HPLC." January 31, 2018. https://doi.org/10.5281/zenodo.2531418.

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New Analytical method was developed for the estimation of Lamivudine and Dolutegravir in drug product by liquid chromatography. The chromatographic separation was achieved on C18 column (Eclipse XDB-Phenyl 250*4.6mm) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Methanol (300:700). The flow rate was 1.0ml/ minute and ultra violet detector at 260m. The average retention time for Lamivudine and Dolutegravir found to be 2.412 min and 3.263 min. the proposed method was validated for selectivity, precision, linearity and

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26

Uppalapati.Jyothi*1, Dr.Parimi.Umadevi2. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR DRUG PRODUCT BY RP-HPLC METHOD." August 31, 2017. https://doi.org/10.5281/zenodo.2526771.

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A novel reversed phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of Sofosbuvir and Velpatasvir drug product by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Methanol (42:58). The flow rate was 1.0 ml/ minute and ultra violet detector at 269nm. The average retention time for Sofosbuvir and Velpatasvir found to be 3.44 and 4.68 min. The proposed method was vali

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27

M., Srinivasa Rao* Dr. K. Rambabu. "DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DACLATASVIR AND SOFOSBUVIR IN DRUG PRODUCT BY RP-HPLC." January 31, 2018. https://doi.org/10.5281/zenodo.2531416.

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New Analytical method was developed for the estimation of Daclatasvir and Sofosbuvir in drug product by liquid chromatography. The chromatographic separation was achieved on C18 column (Phenyl XDB 250*4.6mm) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water : Acetonitrile(500:500). The flow rate was 1.0ml/ minute and ultra violet detector at 275nm. The average retention time for Daclatasvir and Sofosbuvir found to be 2.805 min and 3.743 min. the proposed method was validated for selectivity, precision, linearity and accu

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28

Ramakrishna, Vellalacheruvu, Sai Leela R., and K. Ravindranath L. "Synthesis of a Novel products of 1, 3, 4 - Oxadiazole Contain in Thiozolid- 4- one Derivatives." July 28, 2017. https://doi.org/10.5281/zenodo.3969760.

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8-(benzyloxy) quinoline-5-carbaldehyde (1) was converted into 2-(8-(benzyloxy) quinolin-5-yl)-3-(4-(trifluoro- methyl) phenyl) thiazolidin-4-one (3) by using conventional methods of schiff’s base and cyclised using mercapto acetic acid and anhydrous ZnCl2 in 1,4 Diaoxane. These intermediate (3) was converted to 2-((5-(4- oxo-3-(4-(trifluoromethyl) phenyl) thiazolidin-2-yl) quinolin-8-yl) oxy) acetohydrazide (6) by using hydrogenolysis and treated with Ethyl bromo acetate and hydrazine hydrate. The intermediate (6) was converted into thiozolidine attached 1,3,4 oxa diazole derivatives (7a

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29

Biradar, D. T. "Synthesis of Schiff’s Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes." International Journal of Current Science Research and Review 04, no. 07 (2021). http://dx.doi.org/10.47191/ijcsrr/v4-i7-09.

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Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported for one-pot multi component cyclo-condensation of an alkayane urea / Thiourea and Aldehyde to 2- amino-4H-1, 3-Oxazines or Thiazines. Different catalysts are reported like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal and Co-workers have utilized perchloric acid (HClO4) supported on silica gel as catalyst under solvent free condition ytterbium trifluorate [Yb(OTF)3] plays role of Lewis acid. It is also used in several Diel’s-Alder cyclo-addition reactions.

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30

Ceper, Tolga, Supun Mohotti, Leon Lange, and Felix Schacher. "Polyampholyte Hydrogels with pH-Dependent Swelling for Controlled Catch & Release of Model Dyes." Organic Materials, December 13, 2023. http://dx.doi.org/10.1055/a-2228-4757.

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Polyampholyte hydrogels with tunable charge are synthesized by a facile two-step approach including the free radical crosslinking copolymerization of tert-butoxycarbonylaminomethylacrylate (tBAMA) with N,Nˊ-Methylenebisacrylamide and subsequent deprotection. Thermal, photo- and redox-initiating methods were utilized in the synthesis of crosslinked PtBAMA and the resulting polymer networks swell during deprotection in a mixture of trifluoro acetic acid/water. While the crosslinked PtBAMA forms organogels in various organic solvents such as chloroform, acetone and DMSO, polydehydroalanine (PDha)

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31

Pezzola, Silvia, Mariano Venanzi, Pierluca Galloni, Valeria Conte, and Federica Sabuzi. "Easy to Use DFT Approach for Computational pKa Determination of Carboxylic Acids." Chemistry – A European Journal, October 30, 2023. http://dx.doi.org/10.1002/chem.202303167.

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In pKa computational determination, the challenge in exploring and fostering new methodologies and approaches goes in parallel with the amelioration of computational performances. In this paper a “ready to use methodology” has been compared to other strategies, such as the re‐shaping in solvation cavity (Bondi radius re‐shaping), wanting to assess its reliability in predicting the pKa of a broad list of carboxylic acids. Thus, the functionals B3LYP and CAM‐B3LYP have been selected, using SMD as continuum solvation model. Exploiting our previous results, two water molecules were made explicit o

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Kumar Bandaru, Sai Pavan, and Mukthinuthalapati Mathrusri Annapurna. "A validated stability indicating RP-UFLC method for the estimation of Trifluridine – Anti viral drug." Research Journal of Pharmacy and Technology, June 28, 2022, 2681–87. http://dx.doi.org/10.52711/0974-360x.2022.00448.

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Trifluridine, also known as trifluoro thymidine is an anti-viral drug used for the treatment of viral infections of eyes. A new validated RP-UFLC method has been developed for the determination of Trifluridine using Shimadzu Model UFLC system SPD-M20A 230V with PDA detector and LC- 20AD pumps and C18 Shim-pack GWS HPLC packed column (250 mm × 4.60 mm, 5 μm) in in ophthalmic preparations. Mobile phase consisting of acetonitrile: 10 mM potasium dihydrogen phosphate buffer adjusted pH to 3.5 with dilute tri fluro acetic acid (70:30 v/v) (Isocratic mode) with 1.0 mL/min flow rate (Detection wavele

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Gollu, Gowri, and Sowjanya Gummadi. "A Novel Stability Indicating RP-HPLC Method for Simultaneous Quantification of Serdexmethylphenidate and Dexmethylphenidate in Fixed Dosage Form." Journal of Chromatographic Science, February 12, 2022. http://dx.doi.org/10.1093/chromsci/bmac011.

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Abstract A simple, robust stability indicating RP-HPLC method was developed for simultaneous quantification of serdexmethyl phenidate and dexmethyl phenidate in a fixed capsule dosage form. This is the first method to be reported for simultaneous estimation and quantification of degradation products produced from forced stressing of the dosage form as per ICH guidelines. The chromatographic separation was attained on Waters X-terra C18 column using a mixture of trifluoro acetic acid and acetonitrile (70:30 v/v) as mobile phase with a flow rate of 1 mL, monitored at 265 nm over a run time of 10

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Sarat, P. Sunand, and D. Ramachandran. "RP-HPLC Method for Quantification of Emtricitabine and Tenofovir Alafenamide Fumarate Drug Substance and Tablet Dosage Form." Journal of Pharmaceutical Research International, September 17, 2021, 189–96. http://dx.doi.org/10.9734/jpri/2021/v33i44a32606.

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Aim: The primary objective of the research work is to develop a effective, sensitive, economical and simple reverse phase HPLC method to estimate Emtricitabine and tenofovir alafenamide fumarate in its pure and binary mixture of tablets. Study Design: HPLC based Quantification Studies. Place and Duration of Study: 1Department of Chemistry, Acharya Nagarjuna University,Guntur, Andhra Pradesh between April 2019 and August 2020. Methodology: Separation of the analytes were done by using Eclipse XDB-Phenyl (250 x 4.6mm, 5µ,100 A0) column and a mobile phase ratio of 30:10:70 perce

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Shobha, D., M. Adharvana Chari, and K. H. Ahn. "ChemInform Abstract: An Efficient Biginelli One-Pot Synthesis of New Benzoxazole-Substituted Dihydropyrimidinones and Thiones Catalyzed by Trifluoro Acetic Acid under Solvent-Free Conditions." ChemInform 41, no. 2 (2010). http://dx.doi.org/10.1002/chin.201002173.

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"Simultaneous Estimation and Stability Indicating Method of Vildagliptin And Dapagliflozin by RP-HPLC in Pharmaceutical Dosage Form." International Internal Medicine Journal 2, no. 4 (2024): 01–06. http://dx.doi.org/10.33140/iimj.02.04.02.

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Vildagliptin and Dapagliflozin drugs are used for the management of diabetes.The primary objective of the proposed research was to develop and validate analytical methods for simultaneous quantification of vildagliptin and dapagliflozin in pharmaceutical dosage form. Both the drugs were subjected to force degradation to ensure stability of pharmaceutical products. The HPLC method development was carried out on C18 column (250mm*4.6mm,5µm particle size). The chromatographic separation was achieved by isocratic mode with a mixture of Methanol: 0.01% Trifluoro acetic acid (pH-2.78) in the ratio o

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Singh, Vijay, Suresh Rajaputra, Sovannary Phok, Goutham Chintakula, and Gayatri Sagi. "Copper Phthalocyanine Nanowire Based Solar Cells." MRS Proceedings 1031 (2007). http://dx.doi.org/10.1557/proc-1031-h13-27.

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AbstractPhotovoltaic devices based on organic semiconductors are of interest because of their potential as flexible, lightweight and inexpensive devices. One of the promising devices, involves the heterojunction between copper phthalocyanine (CuPc) and 3,4,9,10-perylenetetracarboxylic bis-benz-imidazole (PTCBI). Earlier, we reported, the highest Voc (1.125V) in a single organic heterojunction solar cell in an ITO/PEDOT:PSS/CuPc/PTCBI/Al structure. Results were interpreted in terms of a modified CuPc-Al Schottky diode for this thin PTCBI layer case and a CuPc-PTCBI heterojunction for the thick

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Lin, Ronghui, Yong Gong, and Rhys Salter. "Synthesis of deuterium‐labeled CCR2 antagonist JNJ‐26131300, [4‐(1 H ‐indol‐ 3‐yl)‐piperidin‐1‐yl]‐{1‐[3‐(3,4,5‐trifluoro‐phenyl)‐acryloyl]‐piperidin‐4‐yl}‐acetic acid." Journal of Labelled Compounds and Radiopharmaceuticals, March 8, 2022. http://dx.doi.org/10.1002/jlcr.3967.

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Mathew, Jane, and Neethu Mathew V. "RP-HPLC hyphenated with ESI -Q-TOF –MS for the detection of potential degradants in dolutegravir." Research Journal of Pharmacy and Technology, March 31, 2023, 1012–16. http://dx.doi.org/10.52711/0974-360x.2023.00169.

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Dolutegravir is an antiviral agent, a second-generation HIV integrase strand transfer inhibitor (INSTI). A precise liquid chromatography-tandem mass spectrometry method has been developed and validated for the detection of potential degradants in Dolutegravir. The goal of this study was to detect major and minor potential degradants that can develop during the various stages of the drug molecule, start from acquiring of raw material for the synthesis, manufacturing, formulation and storage of the final product. With this objective in mind preparative scale HPLC was used to detect possible oxid

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"SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS." CHEMISTRY AND CHEMICAL ENGINEERING 2020, no. 3 (2020): 38–43. http://dx.doi.org/10.51348/ddfx3944.

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Amidoalkylating reagents containing a phthalimide group are used in the synthesis of hard-to-reach primary amines and complex heterocyclic compounds. These types of amidoalkylating compounds are suitable reagents for nucleophilic substituted reactions in acidic media due to their resistance to acids. Result of reactions of amidoalkylating reagents-N-hydroxyethylphthalimide and N-hydroxymethylphthalimide with aliphatic carbonic acids can also produce new bactericidal and fungicidal esters. In this study, halogen acids reacted with N-hydroxymethylphthalimide monochloric acetic acid, monobromic a

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S., Naazneen* A. Sridevi. "DEVELOPMENT OF ASSAY METHOD AND FORCED DEGRADATION STUDY OF LEDIPASVIR AND SOFOSBUVIR BY RP-HPLC IN TABLET FORMULATION." September 30, 2017. https://doi.org/10.5281/zenodo.2526857.

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Chronic hepatitis C virus (HCV) infection is one of the most common etiologies of liver-related mortality throughout the world. Sofosbuvir and ledipasvir are inhobits HCV NS5B and HCV NS5A polymerase respectively. No published LC-MS/MS and HPLC based methods for simultaneous estimation of ledipasvir and sofosbuvir. Therefore, A stability indicating high performance liquid Chromatographic (HPLC) method was developed and validated for estimation of both drugs. Chromatographic separation was achieved on a C18 column [Xterra, 250 x 4.6 mm, 5μ] utilizing a mobile phase consisting a mixture of 0.

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VANKAR, Y. D., and C. T. RAO. "ChemInform Abstract: Reaction of Sulfoxides with Nitriles in Presence of Trifluor-acetic Anhydride and Trifluoroacetic Acid: A Case of Ritter Reaction on Pummerer Intermediate." Chemischer Informationsdienst 16, no. 49 (1985). http://dx.doi.org/10.1002/chin.198549164.

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