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Journal articles on the topic 'Trihydroxyflavone'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Lotulung, Puspa D. N., Sofa Fajriah, Andini Sundowo, and Euis Filaila. "ANTI DIABETIC FLAVANONE COMPOUND FROM THE LEAVES OF Artocarpus communis." Indonesian Journal of Chemistry 9, no. 3 (2010): 505–8. http://dx.doi.org/10.22146/ijc.21524.

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The Flavanone compound with anti diabetic activity was isolated from ethyl acetate extract of Artocarpus communis leaves using column chromatography techniques. The structure of the flavanone compound was elucidated on the basic of spectroscopic evidence and comparison to published values. This compound, 8-geranyl-4,5,7-trihydroxyflavone, showed strong anti diabetic activity on α-glucosidase inhibition assay with IC50 18.120 µg mL-1. Keywords: Artocarpus communis, 8-geranyl-4,5,7-trihydroxyflavone, anti diabetic activity

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2

Wang, Qing-Hu, Jie-Si Wu, Rong-Jun Wu, Na-Ren-Chao-Ke-Tu Han, and Na-Yin-Tai Dai. "Anti-inflammatory effect and isolation of phenylethanoid and acylated flavone glycosides from Panzeria alaschanica." Zeitschrift für Naturforschung B 70, no. 6 (2015): 379–84. http://dx.doi.org/10.1515/znb-2014-0253.

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AbstractThe phytochemical study of the EtOAc extract from Panzeria alaschanica resulted in the isolation of two new acylated flavone glycosides, 5,7,4′-trihydroxyflavone-7-O-(6″-O-[E]-coumaroyl)-β-glucopyranoside (1) and 5,7,4′-trihydroxyflavone-7-O-(2″,6″-O-[E]-dicoumaroyl)-β-glucopyranoside (2), as well as of a known phenylethanoid (verbascoside, 3). The structure of the isolated compounds was elucidated by spectroscopic methods, including ultraviolet spectrophotometry, infrared absorption spectroscopy, electrospray ionization mass spectrometry and 1D nuclear magnetic resonance spectroscopy,

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3

Dung, Nguyen Thi, Pham Thi Ninh, Nguyen Thi Luu, et al. "Phytochemical study of Euphorbia cyathophora collected in Dan Phuong, Hanoi and its antidengue activity against DENV1‐4 virus serotypes." Vietnam Journal of Chemistry 61, no. 3 (2023): 371–77. http://dx.doi.org/10.1002/vjch.202300123.

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AbstractThe ethanol extract from the leaves and twigs of Euphorbia cyathophora showed antiviral activity against four dengue virus serotypes (DENV1‐4), with PRNT50 values of 15.625‐62.5 μg/mL. Eight compounds including germanicol acetate (1), cymbopogone (2), 1‐heptacosanol (3), ethyl α‐L‐arabinofuranoside (4), quercetin (5), 3‐acetoxy‐5,7,3’,4’‐tetrahydroxyflavone (6), 3‐acetoxy‐5,7,4’‐trihydroxyflavone (7), 4’‐acetoxy‐3,5,7‐trihydroxyflavone (8) were isolated from this extract. Compounds 2‐8 were isolated for the first time from Euphorbia cyathophora. Antiviral activity evaluation of compoun

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4

Gupta, Anusha, Shiv Verma, and Sanjay Gupta. "Abstract 962: Activation of natural killer cells by small molecule inhibits growth of BCG-resistant bladder cancer cells." Cancer Research 85, no. 8_Supplement_1 (2025): 962. https://doi.org/10.1158/1538-7445.am2025-962.

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Abstract Bacillus Calmette-Guérin (BCG) is the standard treatment for non-muscle invasive bladder cancer (NMIBC) patients, but resistance declines its efficacy, emphasizing the need for alternative therapies. BCG therapy triggers a specific cytotoxic immune response by activating and expanding CD56/natural killer (NK) cells and T cells, which effectively target and eliminate bladder cancer cells. This priming of NK and T cells by BCG leads to the release of cytokines such as interferon-gamma (IFNγ) and tumor necrosis factor-alpha (TNFα), which stimulate adaptive immunity and enhance tumor cell

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5

Gabrielska, Janina, Jan Oszmiańsk, Romuald Żyłka, and Małgorzata Komorowska. "Antioxidant Activity of Flavones from Scutellaria baicalensis in Lecithin Liposomes." Zeitschrift für Naturforschung C 52, no. 11-12 (1997): 817–23. http://dx.doi.org/10.1515/znc-1997-11-1215.

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Abstract Trihydroxyflavones of Scutellaria baicalensis, Antioxidant Activity, Liposome, Peroxidation, MDA The antioxidant effect of a trihydroxyflavone extract from Scutellaria baicalensis on oxida tion induced by ultraviolet light, was studied with phosphatidylcholine liposome membrane. Also, as standards, the antioxidative activity of baicalin, wogonin, baicalein and butylated hydroxytoluene (BHT) was investigated. Comparison of the protective effects of thecompounds studied against photoinduced lipid peroxidation in lecithin liposome membranes showed that: (1) the inhibitory effect of tho

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6

Tomás-Lorente, Francisco, Manuela M. Garcia-Grau, and Francisco A. Tomás-Barberán. "Flavonoids from Vicia faba Seed Exudates." Zeitschrift für Naturforschung C 45, no. 9-10 (1990): 1070–72. http://dx.doi.org/10.1515/znc-1990-9-1022.

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Abstract From the seed exudates of Vicia faba L. (cv. Muchamiel) the flavonoid aglycones 7,3′,4′-trihydroxyflavone, 7,4′-dihydroxyflavone, quercetin and kaempferol, and the flavonoid glycosides quercetin 7-glucoside and kaempferol 7-glucoside were identified. This is the first time that the flavonoids present in Vicia seed exudates are described. The study of the flavonoids present in legume seed and root exudates is especially important since these substances may act as chemical signals activating or inhibiting Rhizobium nodulation genes. In fact, the activating effect on Rhizobium nod genes

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7

Avdeeva, Elena, Elvira Shults, Marina Skorokhodova, et al. "Flavonol Glycosides from Saussurea controversa and Their Efficiency in Experimental Osteomyelitis." Planta Medica International Open 5, no. 01 (2018): e24-e29. http://dx.doi.org/10.1055/s-0044-100799.

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AbstractFive flavonoids were isolated from leaves of Saussurea controversa, one new flavonoid (5), three described for the first time from the genus Saussurea (1, 2, and 4), and one described previously (3). A number of flavonol glycosides can be easily isolated from the butanol fraction of the ethanol extract from S. controversa. As a result of separating these using column chromatography on silica gel and microcrystalline cellulose, five glycosides of quercetin were isolated in the proportional relationship of 2 (1): 8 (2): 10 (3): 1 (4): 4 (5). The structure of these substances was determin

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8

Zheng, Hongling, Xin Yang, Qiuyu Zhang, Joanne Yi Hui Toy, and Dejian Huang. "Food Grade Synthesis of Hetero-Coupled Biflavones and 3D-Quantitative Structure–Activity Relationship (QSAR) Modeling of Antioxidant Activity." Antioxidants 14, no. 6 (2025): 742. https://doi.org/10.3390/antiox14060742.

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Biflavonoids are a unique subclass of dietary polyphenolic compounds known for their diverse bioactivities. Despite these benefits, these biflavonoids remain largely underexplored due to their limited natural availability and harsh conditions required for their synthesis, which restricts broader research and application in functional foods and nutraceuticals. To address this gap, we synthesized a library of rare biflavonoids using a radical–nucleophile coupling reaction previously reported by our group. The food grade coupling reaction under weakly alkaline water at room temperature led to iso

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9

Wu, Baojian, Shuxing Zhang, and Ming Hu. "Evaluation of 3,3′,4′-Trihydroxyflavone and 3,6,4′-Trihydroxyflavone (4′-O-Glucuronidation) as the in Vitro Functional Markers for Hepatic UGT1A1." Molecular Pharmaceutics 8, no. 6 (2011): 2379–89. http://dx.doi.org/10.1021/mp200300w.

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10

Jaipetch, Thaworn, Sakchai Hongthong, Samreang Bunteang, et al. "A New Ellagic Acid From the Leaves and Twigs of Irvingia malayana." Natural Product Communications 14, no. 5 (2019): 1934578X1984816. http://dx.doi.org/10.1177/1934578x19848164.

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A phytochemical investigation of the leaves and twigs of Irvingia malayana led to the isolation of a new 3,3′,4′-tri- O-methylellagic acid-6″-acetoxy-4- O-β-glucoside (1), along with 3,3′,4′-tri- O-methylellagic acid (2), 3,3′-di- O-methylellagic acid-4- O-β-xyloside (3), 3,3′,4′-tri- O-methylellagic acid-4-β -O-glucoside (4), friedelin (5), friedelinol (6), methyl-3,4,5-trihydroxybenzoate (7), 5,7,4′-trihydroxyflavone-8- C-β-glucopyranoside (8), 5,7,3′,4′-tetrahydroxyflavone-8- C-β-glucopyranoside (9), and 5,3′,4′-trihydroxyflavone-6- C-β-glucopyranoside (10). Their structures were elucidated

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11

Lee, Miok, Srijana Upadhyay, Fuada Mariyam, et al. "Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)." International Journal of Molecular Sciences 24, no. 9 (2023): 8152. http://dx.doi.org/10.3390/ijms24098152.

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It was recently reported that the hydroxyflavones quercetin and kaempferol bind the orphan nuclear receptor 4A1 (NR4A1, Nur77) and act as antagonists in cancer cells and tumors, and they inhibit pro-oncogenic NR4A1-regulated genes and pathways. In this study, we investigated the interactions of flavone, six hydroxyflavones, seven dihydroxyflavones, three trihydroxyflavones, two tetrahydroxyflavones, and one pentahydroxyflavone with the ligand-binding domain (LBD) of NR4A1 using direct-binding fluorescence and an isothermal titration calorimetry (ITC) assays. Flavone and the hydroxyflavones bou

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12

Wang, Jin, Rong-Guang Zhou, Ting Wu, et al. "Total Synthesis of Apigenin." Journal of Chemical Research 36, no. 3 (2012): 121–22. http://dx.doi.org/10.3184/174751912x13285269293913.

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An efficient method for the synthesis of apigenin (4’,5,7-trihydroxyflavone, a traditional medicine) from phloroglucinol and anisaldehyde has been developed. This transformation features a green method for hydroxyl protection as methyl ethers and a different way for cyclisation using iodine in DMSO. The overall yield of 40% is satisfactory.

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13

Iinuma, Munekazu, Toshiyuki Tanaka, Masayoshi Oyama, and Eckhard Wollenweber. "Two Novel Natural Flavonoids from Primula palinuri." Natural Product Communications 1, no. 11 (2006): 1934578X0600101. http://dx.doi.org/10.1177/1934578x0600101106.

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The farinose exudate produced by Primula palinuri was found to consist of 12 flavones at least. Two of them are novel natural compounds, 2′-hydroxy-2-methoxychalcone and 8,2′,5′-trihydroxyflavone 5′-benzoate. The structure was determined by analysis of MS and 2D NMR spectral data and spectral comparison with the known compounds.

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14

Wollenweber, Eckhard, Karin Mann, Munekazu Iinuma, Toshiyuki Tanaka та Mizuo Mizuno. "5,2′,5′-trihydroxyflavone and 2′,β-dihydroxychalcone from Primula pulverulenta". Phytochemistry 28, № 1 (1989): 295–96. http://dx.doi.org/10.1016/0031-9422(89)85067-8.

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15

Datta, Bidyut Kanti, Tahamina Iasmin, and Mohammad A. Rashid. "Further Flavonoids from Polygonum viscosum Buch-Ham. ex D. Don. (Polygonoceae)." Dhaka University Journal of Pharmaceutical Sciences 15, no. 1 (2016): 27–30. http://dx.doi.org/10.3329/dujps.v15i1.29189.

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Three additional flavonoids such as 5,7,4?-trihydroxy-3,8,3?-trimethoxy flavonol (1), 5,7-dihydroxyflavone (chrysin, 2) and 5,6,7-trihydroxyflavone (baicalein, 3) were obtained from the methanol extract of whole plant of Polygonum viscosum. The structure of the isolated compounds was established exclusively by ultraviolet (UV) spectroscopy, mass spectrometry (MS) and a series of Nuclear Magnetic Resonance (NMR) analysis.Dhaka Univ. J. Pharm. Sci. 15(1): 27-30, 2016 (June)

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16

Espíndola, Cecilia. "Some Nanocarrier’s Properties and Chemical Interaction Mechanisms with Flavones." Molecules 28, no. 6 (2023): 2864. http://dx.doi.org/10.3390/molecules28062864.

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Flavones such as 7,8-dihydroxyflavone (tropoflavin), 5,6,7-trihydroxyflavone (baicalein), 3′,4′,5,6-tetrahydroxyflavone (luteolin), 3,3′,4′,5,5′,7-hexahydroxyflavone (myricetin), 4′,5,7-trihydroxyflavone (apigenin), and 5,7-dihydroxyflavone (chrysin) are important both for their presence in natural products and for their pharmacological applications. However, due to their chemical characteristics and their metabolic processes, they have low solubility and low bioavailability. Knowledge about the physicochemical properties of nanocarriers and the possible mechanisms of covalent and non-covalent

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17

B., Dinda, C. De U., Bhattacharya A., Arima S., Sato N., and Harigaya Y. "Chemical constituents of Argyreia argentea, Millingtonia hortensis and Pyrostegia venusta." Journal of Indian Chemical Society Vol.79, Mar 2002 (2002): 291–93. https://doi.org/10.5281/zenodo.5872116.

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Department of Chemistry, Tripura University, Agartala-799 004, India School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108 8641, Japan <em>Manuscript received 10 January 2001, revised 21 May 2001, accepted 6 August 2001</em> Isolation of five known compounds <em>n</em>-hentriacontanol, <em>β</em>-sitosterol, friedelin, epifriedelinol and epifriedelinol acetate from <em>Argyreia argentea </em>aerial parts; four known compounds nonacosanoic acid, ursolic acid, oleanolic acid and 6-methoxy-5,7,4'- trihydroxyflavone from <em>Millingtonia hortensis </em>flower, and f

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18

Lee, Eunjung, Ki-Woong Jeong, Areum Shin, and Yangmee Kim. "Anti-inflammatory Activity of 3,6,3'-Trihydroxyflavone in Mouse Macrophages, In vitro." Bulletin of the Korean Chemical Society 35, no. 11 (2014): 3169–74. http://dx.doi.org/10.5012/bkcs.2014.35.11.3169.

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19

Ono, Katsuhiko, Hideo Nakane, Masanori Fukushima, Jean-Claude Chermann, and Françoise Barré-Sinoussi. "Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone." Biochemical and Biophysical Research Communications 160, no. 3 (1989): 982–87. http://dx.doi.org/10.1016/s0006-291x(89)80097-x.

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20

Katagiri, Yasufumi, Yasuyuki Hashidoko, and Satoshi Tahara. "Localization of Flavonoids in the Yellow Lupin Seedlings and Their UV-B-absorbing Potential." Zeitschrift für Naturforschung C 57, no. 9-10 (2002): 811–16. http://dx.doi.org/10.1515/znc-2002-9-1010.

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Quantification of the flavonoids in yellow lupin (Lupinus luteus; Leguminosae) seedlings revealed that a flavone glucoside, 7-O-β-(2-O-β-rhamnosyl)glucosyl-4′,5,7-trihydroxyflavone (apigenine 7-O-β-neohesperidoside), is rich in the epicotyl and cotyledon. In hypocotyls and roots, 8-C-β-glucosyl-4′,5,7-trihydroxyisoflavone (genistein 8-C-β-glucoside) was a predominant flavonoid constituent. The roles of the localized flavonoids are briefly discussed relating to defense against biotic and abiotic external stresses.

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21

Wang, Xiang, Yujia Cao, Siyu Chen, Xin Yang, Jinsong Bian, and Dejian Huang. "Antioxidant and Anti-Inflammatory Effects of 6,3’,4´- and 7,3´,4´-Trihydroxyflavone on 2D and 3D RAW264.7 Models." Antioxidants 12, no. 1 (2023): 204. http://dx.doi.org/10.3390/antiox12010204.

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Dietary flavones 6,3´,4´-trihydroxyflavone (6,3´,4´-HOFL) and 7,3´,4´-trihydroxyflavone (7,3´,4´-HOFL) showed preliminary antioxidant and anti-inflammatory activities in a two-dimensional (2D) cell culture model. However, their action mechanisms remain unclear, and the anti-inflammatory activities have not been studied in a reliable three-dimensional (3D) cell model. Therefore, in the current study, the antioxidant potency was examined by their scavenging ability of cellular reactive oxygen species. Anti-inflammatory activities were examined via their inhibitory effects on inflammatory mediato

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22

Al-Mekhlafi, Nabil Ali, Khozirah Shaari, Faridah Abas та ін. "New Flavan and Alkyl α,β-Lactones from the Stem Bark of Horsfieldia Superba". Natural Product Communications 8, № 4 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800409.

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In the present study phytochemical investigation of the methanol extract of the stem bark of Horsfieldia superba led to the isolation of twenty compounds (1-20), of which three (1-3) were new. However, compounds 2 and 3 were previously reported as synthetic α, β-lactones. The compounds were characterized as (-)-3,4′,7-trihydroxy-3′-methoxyflavan (1), (-)-5,6-dihydro-6-undecyl-2 H-pyran-2-one (2), and (-)-5,6-dihydro-6-tridecyl-2 H-pyran-2-one (3). Seventeen other known compounds were also isolated and identified as (-)-viridiflorol (4), hexacosanoic acid (5), β-sitosterol (6), methyl 2,4-dihyd

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23

Hewage, Susara Ruwan Kumara Madduma, Mei Jing Piao, Ki Cheon Kim, et al. "Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress." Biomolecules & Therapeutics 23, no. 2 (2015): 165–73. http://dx.doi.org/10.4062/biomolther.2014.130.

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24

Dsouza, Dorin, and Lakshmidevi Nanjaiah. "Wound healing activity of 3, 3′, 4′-Trihydroxyflavone, isolated from Justicia wynaadensis." Wound Medicine 19 (December 2017): 10–14. http://dx.doi.org/10.1016/j.wndm.2017.09.003.

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25

Layne, Tanya H., William F. Reynolds, Stewart McLean, and Winston F. Tinto. "Secondary Metabolites from Clerodendrum Chinense." Natural Product Communications 3, no. 11 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301108.

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Chemical studies carried out on Clerodendrum chinense yielded three new compounds including the steroid (22E, 24S)-stigmasta-4, 22, 25-trien-3-one (1), the flavone glycoside 7, 8, 4′-trihydroxyflavone-6-O-β-D-glucuronopyranoside (2) and the epimeric neo-clerodane 14, 15-dihydro-15ξ-hydroxyclerodendrin A (3). Two acetylated derivatives of compound 3-, 2α-acetoxy-14, 15-dihydro-15ξ-hydroxyclerodendrin A (4) and 2α-acetoxy-14, 15-dihydro-15ξ-methoxyclerodendrin A (5) were also prepared, which have not been reported previously. The structure of each compound was elucidated by spectroscopic means.

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26

Afolayan, A. J., and J. J. M. Meyer. "The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens." Journal of Ethnopharmacology 57, no. 3 (1997): 177–81. http://dx.doi.org/10.1016/s0378-8741(97)00065-2.

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27

Kim, Yeong Sang, Samantha G. L. Keyser, and John S. Schneekloth. "Synthesis of 2′,3′,4′-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation." Bioorganic & Medicinal Chemistry Letters 24, no. 4 (2014): 1094–97. http://dx.doi.org/10.1016/j.bmcl.2014.01.010.

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28

Kim, Eun‐Nam, Yu Gyeong Kim, Jeong‐Hyung Lee, Byung Sun Min, and Gil‐Saeng Jeong. "6,7,4 ′ ‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo." Phytotherapy Research 33, no. 11 (2019): 2948–59. http://dx.doi.org/10.1002/ptr.6468.

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29

Shang, Chao, Yongkui Zhang, Xue You, et al. "The effect of 7,8,4´-trihydroxyflavone on tyrosinase activity and conformation: Spectroscopy and docking studies." Luminescence 33, no. 4 (2018): 681–91. http://dx.doi.org/10.1002/bio.3464.

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30

Primus, Phoebe Sussana, Muhammad Hazran Ismail, Nabila Elyana Adnan, Carol Hsin-Yi Wu, Chao-Lin Kao, and Yeun-Mun Choo. "Chemical Constituents and Anti-Neuroblastoma Activity from Boesenbergia stenophylla." Sains Malaysiana 51, no. 4 (2022): 1075–84. http://dx.doi.org/10.17576/jsm-2022-5104-10.

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Three diarylheptanoids and one flavonoid, i.e. 7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (4), 5R-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one (5), 1,7-diphenylhept-4-en-3-one (6), and 3,5,7-trihydroxyflavone (7) were isolated and characterized from the rhizome of Boesenbergia stenophylla. Compounds 2 and 4 displayed excellent anti-neuroblastoma activity which reduces the cell viability to 30% and 20%, respectively. The results from the molecular docking experiments targeting the protein kinases regulating neuroblastoma cell survival (PI3K/AKT1 signalling pathway) are

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31

Chmiel, Marcelina, and Monika Stompor-Gorący. "Promising Role of the Scutellaria baicalensis Root Hydroxyflavone–Baicalein in the Prevention and Treatment of Human Diseases." International Journal of Molecular Sciences 24, no. 5 (2023): 4732. http://dx.doi.org/10.3390/ijms24054732.

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Plant roots, due to a high content of natural antioxidants for many years, have been used in herbal medicine. It has been documented that the extract of Baikal skullcap (Scutellaria baicalensis) has hepatoprotective, calming, antiallergic, and anti-inflammatory properties. Flavonoid compounds found in the extract, including baicalein, have strong antiradical activity, which improves overall health and increases feelings of well-being. Plant-derived bioactive compounds with antioxidant activity have for a long time been used as an alternative source of medicines to treat oxidative stress-relate

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32

Abid, Rameesha, Shakira Ghazanfar, Arshad Farid, et al. "Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways." Molecules 27, no. 13 (2022): 4304. http://dx.doi.org/10.3390/molecules27134304.

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Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases in many mammalian bodies and promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities and numerous bioactive properties due to which it has been considered as a traditional medicine for decades. Apigenin shows synergistic effects in combined treatment with sorafenib in the HepG2 human cell line (HCC) in less time and statistically reduces the viability of tumor cells, migration, gene expression and apoptosis. The combinatio

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33

Kim, Ki Cheon, In Kyung Lee, Kyoung Ah Kang, Hye Sun Kim, Sam Sik Kang, and Jin Won Hyun. "Baicalein (5,6,7-trihydroxyflavone) reduces oxidative stress-induced DNA damage by upregulating the DNA repair system." Cell Biology and Toxicology 28, no. 6 (2012): 421–33. http://dx.doi.org/10.1007/s10565-012-9233-y.

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34

Prasad, A., and S. Kumari. "Flavonoid: A Mini Review on Galangin." Asian Journal of Chemistry 34, no. 1 (2021): 18–24. http://dx.doi.org/10.14233/ajchem.2022.23555.

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Studies on flavonoids from plant sources has gained a momentum due to their versatile health benefits. The main sources of flavonoids in humans are fruits, vegetables, red wine and tea. They are small molecular weight secondary metabolites produced in different parts of the plant such as seeds, bark, root, fruits and flowers. Galangin (3,5,7-trihydroxyflavone) a naturally occurring flavonoid is present in roots of Alpinia officinarum, honey and propolis. Its extraction and detection has been reported using various methods such as chromatography, spectrophotometric and electrochemical methods a

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35

Dsouza, Dorin, and Lakshmidevi Nanjaiah. "Antibacterial activity of 3,3′,4′-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection." Brazilian Journal of Microbiology 49, no. 1 (2018): 152–61. http://dx.doi.org/10.1016/j.bjm.2017.05.002.

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36

Panda, Sunanda, and Anand Kar. "Apigenin (4‘,5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice." Journal of Pharmacy and Pharmacology 59, no. 11 (2007): 1543–48. http://dx.doi.org/10.1211/jpp.59.11.0012.

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37

Marques, Joana, Artur M. S. Silva, Maria Paula M. Marques, and Susana S. Braga. "Ruthenium(II) trithiacyclononane complexes of 7,3′,4′-trihydroxyflavone, chrysin and tectochrysin: Synthesis, characterisation, and cytotoxic evaluation." Inorganica Chimica Acta 488 (March 2019): 71–79. http://dx.doi.org/10.1016/j.ica.2019.01.003.

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38

March, Raymond E., Darcy C. Burns, and David A. Ellis. "Empirically predicted13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4′-trihydroxyflavone and from 7,8-dihydroxyflavone." Magnetic Resonance in Chemistry 46, no. 7 (2008): 680–82. http://dx.doi.org/10.1002/mrc.2232.

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Ruben, Algren. "UJI AKTIVITAS ANTIBAKTERI FRAKSI BUTANOL, ETIL ASETAT, DAN n-HEKSAN DAUN BINAHONG (Anredera cordifolia (Ten.) Stennis) TERHADAP BAKTERI Propionibacterium acnes ATCC 37533 SECARA IN VITRO." INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL 5, no. 1 (2020): 1–7. http://dx.doi.org/10.52447/inspj.v5i1.1821.

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Salah satu tanaman yang berkhasiat sebagai antibakteri adalah daun binahong. Kandungan senyawa dari daun binahong adalah flavonoid yaitu (8-Glukopyranosyl-4’5,7-trihydroxyflavone), Steroid yaitu (Stigmasterol).Tujuan dari penelitian ini untuk melihat apakah fraksi butanol, etil asetat dan n-heksan daun binahong (Anredera cordifolia (Ten.) Steenis) dapat menghambat bakteri Propionibacterium acnes. Pada uji aktivitas antibakteri menggunakan mueler Hinton Agar (MHA) dengan metode difusi cakram menggunakan konsentrasi 200 mg/ml, 100 mg/ml, 50 mg/ml, 25 mg/ml, 25 mg/ml serta klindamisin sebagai kon

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Yangari, Betty, Kelsey Zou, Kala Mignone, Huisheng Xie, and Jianliang Zhang. "Abstract 6986: Discovery of trihydroxyflavone from botanical sources targeting the epigenomic driver NSD3 in lung squamous cell carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 6986. https://doi.org/10.1158/1538-7445.am2025-6986.

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Abstract Lung squamous cell carcinoma (LSCC) represents a highly aggressive subtype of non-small cell lung cancer, accounting for approximately 30% of all lung cancer cases. Despite its significant prevalence, effective targeted therapies for LSCC remain elusive, contributing to poor clinical outcomes. Recent molecular research has identified NSD3 as a critical oncogenic driver, with gene amplification observed in 60% of LSCC cases. NSD3 catalyzes the di-methylation of histone H3K36, leading to the epigenetic upregulation of key oncogenes such as MYC, CDK1, and CCNB1. Furthermore, the hyperact

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Miličević, Ante. "Estimating flavonoid oxidation potentials: mechanisms and charge-related regression models." Archives of Industrial Hygiene and Toxicology 74, no. 2 (2023): 99–105. http://dx.doi.org/10.2478/aiht-2023-74-3721.

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Abstract In this paper, I tested our quadratic regression models for the estimation of flavonoid oxidation potentials based on spin populations, the differences in the net atomic charges between a cation and a neutral flavonoid, between a radical and an anion of a flavonoid, and between a radical and a neutral flavonoid on a larger set of flavonoids (N = 35). By including six new flavonoids (5,6,7-trihydroxyflavone, 3,3’,4’,7-tetrahydroxyflavone, 3,7-dihydroxyflavone, 4’,7-dihydroxyflavone, 4’,5,7-trihydroxyisoflavone, and 6-hydroxyflavone), we created a respectable calibration set of 35 flavo

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da Silva, Leomara Andrade, Maria Teresa Fachin-Espinar, David Ribeiro da Silva, Nadia Cristina Falcao-Bücker, and Cecilia Veronica Nunez. "Phytochemical study and biological evaluation of Campsiandra comosa hexane and methanol extracts." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 24, no. 4 (2025): 585–99. https://doi.org/10.37360/blacpma.25.24.4.41.

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Campsiandra comosa (Fabaceae) is a medicinal Amazonian plant with no previous chemical fractionation. Thus, the objective of the current study was to evaluate extract toxicity on Artemia salina, antioxidant activity (DPPH and Fe3+/Phenanthroline), and antibacterial and antiangiogenic activity of C. comosa, and to perform a chemical fractionation. Leaf hexane and trunk bark methanolic extracts, after phytochemical prospection, were fractionated. Isolated substances were identified by nuclear magnetic resonance (NMR) (1D and 2D)and mass spectrometry (MS). Chromatographic fractionation allowed th

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Kwon, Seung-Hwan, Sa-Ik Hong, Shi-Xun Ma, Seok-Yong Lee, and Choon-Gon Jang. "3′,4′,7-Trihydroxyflavone prevents apoptotic cell death in neuronal cells from hydrogen peroxide-induced oxidative stress." Food and Chemical Toxicology 80 (June 2015): 41–51. http://dx.doi.org/10.1016/j.fct.2015.02.014.

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GAO, Hong, Tetsuo NISHIOKA, Jun Kawabata та Takanori KASAI. "Structure-activity Relationships for α-Glucosidase Inhibition of Baicalein, 5,6,7-Trihydroxyflavone: the Effect of A-Ring Substitution". Bioscience, Biotechnology, and Biochemistry 68, № 2 (2004): 369–75. http://dx.doi.org/10.1271/bbb.68.369.

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Vijayakumar, Aparna, Hema Bhagavathi Sarveswari, Sahana Vasudevan, Karthi Shanmugam, Adline Princy Solomon, and Prasanna Neelakantan. "Baicalein Inhibits Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes." Antibiotics 10, no. 2 (2021): 215. http://dx.doi.org/10.3390/antibiotics10020215.

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Dental caries, the most common oral disease, is a major public healthcare burden and affects more than three billion people worldwide. The contemporary understanding of the need for a healthy microbiome and the emergence of antimicrobial resistance has resulted in an urgent need to identify compounds that curb the virulence of pathobionts without microbial killing. Through this study, we have demonstrated for the first time that 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates crucial caries-related virulence phenotypes in Streptococcus mutans. Baicalein significantly inhibited

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Lotulung, Puspa Dewi Narrij, Tjandrawati Mozef, Chandra Risdian, and Akhmad Darmawan. "In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from Artocarpus altilis (Parkinson) Fosberg." Indonesian Journal of Chemistry 14, no. 1 (2014): 7–11. http://dx.doi.org/10.22146/ijc.21261.

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The antidiabetic activity test through a mechanism of inhibition of α-glucosidase enzyme was studied against ethanol, n-hexane, ethyl acetate and n-butanol fractions of ethanol extract of Artocarpus altilis (Parkinson) Fosberg (Moraceae) leaves and four flavonoid compounds isolated from ethyl acetate extracts of A. altilis. Ethyl acetate fraction has strongest antidiabetic activity compared to ethanol, n-hexane, and n-butanol fractions with IC50values5.98,6.79, 440.18and14.42μg/mL, respectively. Four flavonoid compounds (1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-

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Jang, Jung Yoon, Bokyung Sung, and Nam Deuk Kim. "Role of Induced Programmed Cell Death in the Chemopreventive Potential of Apigenin." International Journal of Molecular Sciences 23, no. 7 (2022): 3757. http://dx.doi.org/10.3390/ijms23073757.

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The flavonoid apigenin (4′,5,7-trihydroxyflavone), which is one of the most widely distributed phytochemicals in the plant kingdom, is one of the most thoroughly investigated phenolic components. Previous studies have attributed the physiological effects of apigenin to its anti-allergic, antibacterial, antidiabetic, anti-inflammatory, antioxidant, antiviral, and blood-pressure-lowering properties, and its documented anticancer properties have been attributed to the induction of apoptosis and autophagy, the inhibition of inflammation, angiogenesis, and cell proliferation, and the regulation of

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Ghiƫu, Alexandra, Ioana Zinuca Pavel, Stefana Avram, et al. "An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line." Analytical Cellular Pathology 2021 (June 21, 2021): 1–11. http://dx.doi.org/10.1155/2021/5552664.

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One of the most important class of natural compounds with successful preclinical results in the management of cancer is the flavonoids. Due to the plethora of biological activities, apigenin (4 ′ ,5,7 trihydroxyflavone) is a main representant of the flavone subclass. Although the antiproliferative and antiangiogenic effects of apigenin were studied on a significant number of human and murine melanoma cell lines, in order to complete the data existing in the literature, the aim of this study is to evaluate the in vitro effect of apigenin on SK-MEL-24 human melanoma cell line as well as in vivo

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Uddin, Shahab, and Khawla S. Al-Kuraya. "Apigenin Induces Apoptosis in Primary Effusion Lymphoma." Blood 106, no. 11 (2005): 4807. http://dx.doi.org/10.1182/blood.v106.11.4807.4807.

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Abstract The mechanisms that regulate induction of the antiapoptotic state and mitogenic signals in primary effusion lymphoma (PEL) are not well known. In efforts to identify novel approaches to block the proliferation of PEL cells, we found that apigenin (4′,5,7,-trihydroxyflavone), a flavonoid, induces apoptosis in a dose dependent manner in several PEL cell lines. Such effects of apigenin appear to result from suppression of the constitutively active AKT, FOXO transcription factor and GSK3. Our data also demonstrate that apigenin induces loss of mitochondrial membrane potential with subsequ

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Naponelli, Valeria, Maria Teresa Rocchetti, and Domenica Mangieri. "Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading." International Journal of Molecular Sciences 25, no. 10 (2024): 5569. http://dx.doi.org/10.3390/ijms25105569.

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Due to its propensity to metastasize, cancer remains one of the leading causes of death worldwide. Thanks in part to their intrinsic low cytotoxicity, the effects of the flavonoid family in the prevention and treatment of various human cancers, both in vitro and in vivo, have received increasing attention in recent years. It is well documented that Apigenin (4′,5,7-trihydroxyflavone), among other flavonoids, is able to modulate key signaling molecules involved in the initiation of cancer cell proliferation, invasion, and metastasis, including JAK/STAT, PI3K/Akt/mTOR, MAPK/ERK, NF-κB, and Wnt/β

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