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Dissertations / Theses on the topic 'TRIM protein'

Author: Grafiati

Published: 1 April 2023

Last updated: 31 July 2025

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1

Najmabadi, Sepideh. "Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17919.

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Laing distal myopathy is inherited in an autosomal dominant manner usually before the age of five that initially involves the dorsiflexion in the ankles’ and in big toes to the finger extensors. Weakness of the flexor muscles in the neck is seen in most affected individuals and mild facial weakness is also often present. Hypertrophic or dilated cardiomyopathy, starting at birth to respectively second or third decade of life, is the symptom in the affected humans.This study performed on Drosophila melanogaster, has evaluated whether feeding MuRF1 enzyme (which has a similar role as ABBA enzyme)

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2

Zhang, Xuzhe. "Eutherian-specific gene TRIML2 attenuates inflammation in the evolution of placentation." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573576401238203.

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3

MASCARO, MARTINA. "Ruolo di TRIM18, gene che causa la sindrome di Opitz, nel controllo della ciliogenesi attraverso l'autofagia." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2996095.

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TRIM18/MID1 è una E3-Ubiquitina ligasi appartenente alla famiglia di proteine TRIM che si localizza sui microtubuli. Le mutazioni con perdita di funzione nel gene MID1 sono state associate alla forma legata all'X della sindrome di Opitz, una malattia genetica caratterizzata da difetti nello sviluppo della linea mediana ventrale. All'interno della cellula, MID1 esiste come un complesso macromolecolare microtubulare, costituito da diversi interattori non tutti ancora identificati. Tra questi, α4 è una delle subunità regolatorie della proteina fosfatasi 2A (PP2A). È stato riportato che MID1 riduc

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4

Demange, Antonin. "Protéines à motif tripartite (TRIM) chez le porc (Sus scrofa) et réplication du rétrovirus endogène porcin." Phd thesis, Université Rennes 1, 2013. http://tel.archives-ouvertes.fr/tel-00992386.

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Les études des interactions entre cellules hôtes et rétrovirus ont conduit à définir le concept de restriction virale dont les facteurs constituent une part de l'immunité innée des cellules hôtes. Ces facteurs contribuent au contrôle des rétrovirus endogènes (ERV) dont l'émergence peut être associée à certaines pathologies telles que des leucémies ou des immunodéficiences. Chez le porc, certains ERV (PERV) sont réplicatifs, pourtant aucune pathologie ne leur a, à ce jour, été associée. Les mécanismes de restriction virale impliqués dans ce phénomène ont fait l'objet de nombreuses études. Elles

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5

Fraser, S. J. "Characterising retroviral restriction by TRIM proteins." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1532045/.

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Tripartite motif (TRIM) proteins are numerous in the human proteome, and a number of these molecules are known to restrict retroviral replication. TRIM5α (T5α) is one such factor. It targets the viral capsid and imposes a block to infection between entry and reverse transcription. Capsid recognition is mediated by the C-terminal B30.2 domain, which contains surface-exposed loops of high amino acid variability. Restriction is then effected via proteasome recruitment and the induction of innate immune cascades. Although T5α is well-characterised in this respect, other factors – such as the highl

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6

Fekete, Richard Alfred. "Characterizing the protein and DNA interactions of the F plasmid DNA binding protein, TraM." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60291.pdf.

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7

Marafie, Sulaiman. "TRIM7, a novel binding protein of the mTORC2 component Sin1." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/trim7-a-novel-binding-protein-of-the-mtorc2-component-sin1(c344b542-0706-4ec0-be06-ce6683cee52e).html.

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TRIM7 is a member of the TRIM (tripartite motif-containing) protein superfamily. This family has been implicated in many disorders such as genetic diseases, neurological diseases, and cancers. Little is known about the function of TRIM7 except that it interacts with glycogenin and may regulate glycogen biosynthesis. Recently, a yeast two-hybrid protein-protein interaction screen revealed the binding of TRIM7 to Sin1, a protein found in a complex with the mammalian target of rapamycin (mTOR) protein kinase. mTOR can form two complexes, mTORC1 and mTORC2, which are important for cell growth, dif

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8

Simpson, Shmona. "Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:1af588ba-603a-4f39-9443-bb1a95d983f5.

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HIV-2 differs from HIV-1 in that many infected people experience normal survival, whilst only 20&percnt; progress rapidly to AIDS. Understanding mechanisms of delayed HIV-2 disease progression could provide new insights into HIV control. The Caio Community Cohort was established in Guinea-Bissau in the setting of high HIV-2 prevalence. This thesis investigates the role of polymorphic host restriction factors of the TRIM family in HIV-2 outcome. TRIM proteins are a family of E3 ubiquitin-ligases, where closely-related TRIM5α and TRIM22 are thought to inhibit HIV-1 transcription, uncoating

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9

Liu, Sunbin. "Investigation of protein-protein interactions within the human spliceosomal U4/U6.U5 tri-snRNP particle." Doctoral thesis, [S.l.] : [s.n.], 2005. http://webdoc.sub.gwdg.de/diss/2005/liu/liu.pdf.

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10

Xin, Gang. "The role of TREM proteins in lung homeostasis and inflammation." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9058.

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The family of Triggering Receptors Expressed on Myeloid Cells (TREM) contain novel activating receptors of the Ig super-family that are expressed on myeloid cells. TREM-1 is a transmembrane glycoprotein expressed on blood neutrophils and a subset of monocytes, but not on lymphocytes or other cell types and is upregulated by bacterial and fungal products. TREM-1 signaling potentiates the outcome of Toll-like Receptor (TLR) signaling. Blockade of TREM-1 prevents experimentally induced septic shock. In addition to the membrane-bound form, a soluble TREM-1 molecule (sTREM-1) exists that regulates

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11

Ruiz, Echartea Maria Elisa. "Pairwise and Multi-Component Protein-Protein Docking Using Exhaustive Branch-and-Bound Tri-Dimensional Rotational Searches." Electronic Thesis or Diss., Université de Lorraine, 2019. http://www.theses.fr/2019LORR0306.

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La détermination des structures tri-dimensionnelles (3D) des complexes protéiques est cruciale pour l’avancement des recherches sur les processus biologiques qui permettent, par exemple, de comprendre le développement de certaines maladies et, si possible, de les prévenir ou de les traiter. Face à l’intérêt des complexes protéiques pour la recherche, les difficultés et le coût élevé des méthodes expérimentales de détermination des structures 3D des protéines ont encouragé l’utilisation de l’informatique pour développer des outils capables de combler le fossé, comme par exemple les algorithmes

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12

Ahmadi, Farhana. "Interaction of toll-like receptor 4 with the adaptor proteins MAL and TRAM." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610209.

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13

Rüßmann, Florian. "The eukaryotic chaperonin TRiC domain-wise folding of multi-domain proteins." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-157246.

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14

Villebeck, Laila. "Structural rearrangements of actins interacting with the Chaperonin systems TRiC/Prefoldin and GroEL/ES." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/tek1099s.pdf.

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15

McCarthy, Kevin Raymond. "Viral and Host Determinants of Primate Lentivirus Restriction by Old World Primate TRIM5alpha Proteins." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065027.

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The host restriction factor TRIM5α mediates a post-entry, pre-integration block to retroviral infection that depends upon recognition of the viral capsid by the TRIM5α PRYSPRY domain. The two predominant alleles of rhesus macaque TRIM5α (rhTRIM5αQ and rhTRIM5αTFP) restrict HIV 1, but cannot restrict the macaque-adapted virus SIVmac239. To investigate how TRIM5α recognizes retroviral capsids, we exploited the differential sensitivities of these two viruses to identify gain-of-sensitivity mutations in SIVmac239, and we solved the structure of the SIVmac239 capsid N-terminal domain. When mapped o

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16

Gumpper, Kristyn Nicole. "Maintaining Cardiac and Gastric Physiology: TRIM Proteins as Central Factors in Regulation of Organ Homeostasis at the Cellular Level." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563287863754715.

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17

Ghoorah, Anisah W. "Extraction de connaissances pour la modélisation tri-dimensionnelle de l'interactome structural." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0204/document.

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L'étude structurale de l'interactome cellulaire peut conduire à des découvertes intéressantes sur les bases moléculaires de certaines pathologies. La modélisation par homologie et l'amarrage de protéines ("protein docking") sont deux approches informatiques pour modéliser la structure tri-dimensionnelle (3D) d'une interaction protéine-protéine (PPI). Des études précédentes ont montré que ces deux approches donnent de meilleurs résultats quand des données expérimentales sur les PPIs sont prises en compte. Cependant, les données PPI ne sont souvent pas disponibles sous une forme facilement acces

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18

Volkmann, Bianca [Verfasser], Thomas [Akademischer Betreuer] Gramberg, Andreas [Gutachter] Burkovski, and Andreas [Gutachter] Burkovski. "The role of TRIM proteins in retrovirus and retroelement restriction / Bianca Volkmann ; Gutachter: Andreas Burkovski, Andreas Burkovski ; Betreuer: Thomas Gramberg." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1216332967/34.

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19

Zhang, Yanhui, and 张雁惠. "Modulation of transient outward potassium channels by protein tyrosinekinases and demonstration of TRPC and TRPM channels in human atrialmyocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47161644.

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My PhD project investigated the regulation of human cardiac transient outward potassium current (Ito) by protein tyrosine kinases (PTKs) and the functional expression of transient receptor potential (TRP) channels in human atrial myocytes to make an advanced understanding of human cardiac electrophysiology and pathophysiology. The modulation of human cardiac Itoby PTKs was studied in human atrial myocytes and HEK 293 cells expressing hKv4.3 (coding human cardiac Ito). We found that the broad-spectrum PTK inhibitor genistein, the selective EGFR kinase inhibitor AG556, and the Src-family kin

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20

Binkley, Sarah L. "Re(I) Tri-Carbonyl Based Radiopharmaceuticals; Synthesis, in vitro Studies, and Protein Complexation." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1469473412.

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21

TAUBENBLATT, PATRICE. "Tri intracellulaire de la vamp et etude de la proteine moteur kif 1a." Paris 11, 2001. http://www.theses.fr/2001PA112142.

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La vamp 2 est une proteine de la vesicule synaptique essentielle au phenomene d'exocytose. La formation d'un complexe entre la vamp et 2 proteines de la membrane presynaptique (syntaxine et snap 25) va permettre la fusion entre ces 2 structures membranaires et la liberation du neurotransmetteur. Dans un premier temps, nous nous sommes interesses a la localisation subcellulaire de la vamp a la terminaison nerveuse. Grace a une technique de marquages apres cryofracture, nous montrons que la vamp est associee a la membrane presynaptique. Ces resultats suggerent qu'en plus d'une localisation vesic

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22

Ghoorah, Anisah W. "Extraction de connaissances pour la modélisation tri-dimensionnelle de l'interactome structural." Electronic Thesis or Diss., Université de Lorraine, 2012. http://www.theses.fr/2012LORR0204.

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L'étude structurale de l'interactome cellulaire peut conduire à des découvertes intéressantes sur les bases moléculaires de certaines pathologies. La modélisation par homologie et l'amarrage de protéines ("protein docking") sont deux approches informatiques pour modéliser la structure tri-dimensionnelle (3D) d'une interaction protéine-protéine (PPI). Des études précédentes ont montré que ces deux approches donnent de meilleurs résultats quand des données expérimentales sur les PPIs sont prises en compte. Cependant, les données PPI ne sont souvent pas disponibles sous une forme facilement acces

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23

De, Stefano Vittorio. "Origins of specificity in protein modification, reaction patterns of tris-trimesates with human hemoglobin A, water, and n-propylamine." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/NQ45655.pdf.

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24

Rüßmann, Florian Verfasser], and Franz-Ulrich [Akademischer Betreuer] [Hartl. "The eukaryotic chaperonin TRiC domain-wise folding of multi-domain proteins / Florian Rüßmann. Betreuer: Franz-Ulrich Hartl." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1035066866/34.

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25

Rüßmann, Florian [Verfasser], and Franz-Ulrich [Akademischer Betreuer] Hartl. "The eukaryotic chaperonin TRiC domain-wise folding of multi-domain proteins / Florian Rüßmann. Betreuer: Franz-Ulrich Hartl." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-157246.

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26

Becher, Peter Moritz [Verfasser]. "Die Bedeutung des TIR-domain-containing adaptor protein inducing Interferon-ß (TRIF) bei der viralen Myokarditis im murinen Tiermodell / Peter Moritz Becher." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1026789435/34.

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27

Forsthoefel, David J. "A molecular genetic analysis of the role of the Guanine Nucleotide Exchange Factor Trio during Axon Pathfinding in the Embryonic CNS of Drosophila melanogaster." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127241654.

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28

Ghoorah, Anisah. "Extraction de Connaissances pour la Modelisation tri-dimensionnelle de l'Interactome Structural." Phd thesis, Université de Lorraine, 2012. http://tel.archives-ouvertes.fr/tel-00762444.

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L'étude structurale de l'interactome cellulaire peut conduire à des découvertes intéressantes sur les bases moléculaires de certaines pathologies. La modélisation par homologie et l'amarrage de protéines ("protein docking") sont deux approches informatiques pour modéliser la structure tri-dimensionnelle (3D) d'une interaction protéine-protéine (PPI). Des études précédentes ont montré que ces deux approches donnent de meilleurs résultats quand des données expérimentales sur les PPIs sont prises en compte. Cependant, les données PPI ne sont souvent pas disponibles sous une forme facilement acces

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29

Bravo, Silvina Alejandra. "The di/tri-peptide transporters PEPT1 and PEPT2 : expression and regulation in the intestinal Caco-2 and renal SKPT0193 cl.2 cell lines /." Cph. : Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/silvinabravo.htm.

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30

Confavreux, Antoine. "Optimisation des conditions de migration et de détachement de lignées cancéreuses du cancer du sein en vue de leur tri fonctionnel." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10209/document.

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Cette thèse concerne l'étude des propriétés de migration et de détachement de lignées cancéreuses du cancer du sein de type mésenchyme, très métastatique et invasif (MDA-MB-231), ou au contraire de type épithélial et peu invasif (MCF-7). Des techniques de vidéomicroscopie et d'analyse d'images automatisées ont été utilisées afin de tirer des informations sur la dynamique cellulaire sur de grandes populations. Nos expériences sur la migration aléatoire des cellules MDA-MB-231 montrent que les propriétés de déplacement de celles-ci sont liées à la fois à la composition de leur milieu environnant

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31

Dugast, Marc. "Mécanismes de tri impliqués dans le trafic intracellulaire des molécules du CMH II et dans les effets de Nef du VIH-1 sur les CMH et CD4." Paris 7, 2005. http://www.theses.fr/2005PA077016.

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32

Schächterle, Carolin. "Der strukturelle und funktionelle Einfluss des Cytokins IFNgamma auf die Modulation proteasomaler Komplexsubtypen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16849.

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Das 20S Proteasom ist das Kernelement des Ubiquitin-Proteasom-Systems und baut fehlerhafte, nicht mehr benötigte und oxidierte Proteine ab, wobei drei katalytisch aktive Untereinheiten die Polypeptidkette schneiden. Das proinflammatorische Cytokin IFNg induziert die Expression und Inkorporation der alternativen katalytisch aktiven Immunountereinheiten, was in variablen Isoformen des 20S Proteasoms resultiert. Die zusätzliche Assoziation des 19S Regulators, bzw. des PA28 und des PA200 Aktivators an eine Isoform erweitert das Sortiment an proteasomalen Komplexsubtypen. Der zeitliche Verlauf eine

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33

Ecard, Jason. "Mécanismes de tri et voies de transport intracellulaire des protéines de la membrane du lysosome." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS094.pdf.

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Plus d’une soixantaine de protéines différentes sont insérées dans la membrane du lysosome et participent aux différentes fonctions de cet organite. Mais les voies de transport intracellulaire qui mènent les protéines membranaires lysosomales (LMP) jusqu’à cet organite ne sont pas bien comprises. De façon intéressante, certaines LMP présentent des localisations intracellulaires anormales dans certains cancers. C’est notamment le cas de la glycoprotéine LAMP1 qui s’avère surexposée à la surface cellulaire dans plusieurs cancers, où elle y joue plusieurs rôles dans l’agressivité tumorale. Grâce

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34

Collins, Karl Daniel. "The development and application of radical and anionic cyclisations mediated by samarium(II) diodide and protic co-solvents." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-development-and-application-of-radical-and-anionic-cyclisations-mediated-by-samariumii-diodide-and-protic-cosolvents(0e807a8c-d40f-45bb-8d83-26e79ebe9388).html.

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The development of selective SmI2-H2O-mediated mono-reductions of cyclic-1,3-diesters to the corresponding 3-hydroxy acids is described. The reaction proceeds with complete selectivity for cyclic-1,3-diesters over acyclic esters. Sequential one-pot conjugate reduction-ester reduction of alkylidene cyclic-1,3-diesters is also reported. Furthermore, we describe the exploitation of the unusual ketyl radical intermediates formed via single electron reduction of the ester carbonyl in unprecedented 5-exo-trig cyclisations providing access to highly substituted, stereo-defined, cyclopentanols and cyc

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35

Huang, Shu-Yu, and 黃書毓. "Structural Characterization and Molecular Interaction with the TRIM Domains of Promyelocytic Leukemia Protein." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/40271052944316786419.

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博士<br>國立臺灣大學<br>生化科學研究所<br>103<br>PML protein is mainly present inside the nucleus in the form of PML nuclear bodies (PML-NBs) and serves as a SUMO E3 ligase which facilitates SUMOylation on PML itself and proteins in PML-NBs. PML has a conserved N-terminal TRIM/RBCC region comprised of a RING finger domain, two B-boxes and a coiled-coil region. The purpose of this study is to investigate the structural basis of SUMOylation on PML TRIM domains which is essential in the formation of PML-NBs. However, not much of the structural information of PML is known today. In this work we solved the struct

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36

Späth, Kerstin [Verfasser]. "Untersuchungen zur funktionellen Charakterisierung von regulatory-protein T-lymphocyte-1 (rpt-1, Trim 30) / vorgelegt von Kerstin Späth." 2005. http://d-nb.info/973945087/34.

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37

Chang, Chia-Ling, and 張嘉玲. "I. Studies of a Rice Sterile Mutant sstl from Taiwan Rice Insertional Mutants (TRIM) CollectionII. Multifunctional Roles of Rice Yellow Mottle Virus (RYMV) P1 Protein in Host Infection." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/dbh86b.

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博士<br>國立臺灣大學<br>農藝學研究所<br>107<br>Rice (Oryza sativa) is one of the main crops in the world. By 2025, more than 3.9 billion people count rice as daily food energy especially in Asia and Africa. Because of the increased population, the production of rice is still far away behind requirements. Meanwhile, the food safety issue related to feed the world continuously, to adjust crop adaptation in climate change, to establish sustainable agriculture, etc. are urgent to be solved. My study in this thesis will cover two different topics described as followings: First, studies of a rice sterile mutant (

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38

Chang, Jian-Sheng, and 張建盛. "Protein Expression, Purification, and Structural Characterization of Truncated Human TREM-Like Transcript-2." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/39999279592359434152.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>95<br>TREMs, triggering receptor expressed on myeloid cells, belong to a rapidly expanding family of receptors that include activating and inhibitory isoforms encoded by a gene cluster linked to the major histocompatibility complex (MHC) on human chromosome 6. Human TREM-like transcript-2 (hTLT-2), one kind of TREM gene family with 321 amino acids, is a membrane protein and signal receptor expressed on neutrophils, macrophages, and B lymphocytes in innate and adaptive immune system. Until now, the characterization and structural analysis of hTLT-2 remain unclear

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Lin, Yin-Ling, and 林易鈴. "A Trip to Protect Your Heart：Studies of Cardiovascular Nursing Care." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/qx42zw.

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碩士<br>國立陽明大學<br>科技與社會研究所<br>106<br>This study explores cardiovascular nursing care from the perspectives of gender and technology studies. I review studies of cardiovascular epidemiology, medical guideline of heart diseases, and cardiovascular nursing education in school and the hospital. I also review literatures of nurse-patient relationship, nursing guidance, and "gender innovation" studies on female heart diseases. I use multiple research methods in this studies. The empirical data in this study includes my own clinical practice of cardiovascular nursing care, and in-depth interviews of my

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40

Liu, Sunbin [Verfasser]. "Investigation of protein-protein interactions within the human spliceosomal U4/U6.U5 tri-snRNP particle / vorgelegt von Sunbin Liu." 2005. http://d-nb.info/97621802X/34.

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41

Rold, Christopher James. "The role of the cellular proteasome and ubiquitin in post-entry restriction of retroviruses by TRIM5[alpha]." Diss., 2009. http://etd.library.vanderbilt.edu/available/etd-03302009-150129/.

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42

Chang, Po-Chih, and 張博智. "Synthesis and Reactivity Study of Tris(1-pyrazolyl)methane Copper(I) Complexes Relating to the Copper Protein Active Site Modeling Complexes." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/19584927692376547912.

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碩士<br>國立中山大學<br>化學系研究所<br>92<br>Nitrous oxide is a greenhouse gas produced in large quantity by several industrial processes. Efficient means of eliminating N2O are therefore of interest. The denitrification enzyme nitrous oxide reductase (N2OR), which reduces N2O to N2 and water , has recently been shown to contain an unprecedented [Cu4-µ4S] active site. Multinuclear copper sulfide compounds are known but have not been studied in the context of modeling N2OR or as N2O reduction catalysts. The synthesis of new tetranuclear [Cu4-µ4S] compounds is proposed to model the N2OR active site.The purpo

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Choonara, Bibi Fatima. "A Tri-Functionalized Oral Core-Melt Tablet (OCMT) for enhanced delivery of gastro-sensitive proteins and synthetic peptides." Thesis, 2017. https://hdl.handle.net/10539/24911.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfillment of the requirements for the degree of Doctor of Philosophy. Department of Pharmacy and Pharmacology, University of the Witwatersrand, South Africa Johannesburg, 2017.<br>The global pharmaceutical biotechnology industry is continually growing and increased amounts of protein and peptide-based therapeutics are entering into the market. Conventionally, these therapeutic proteins and peptides are administered intravenously, subcutaneously or intramuscularly as oral routes of administration may r

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Häcker, Irina. "Electron microscopic localization of tagged proteins in the yeast S. cerevisiae spliceosomal U4/U6.U5 trisnRNP." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-AD0F-E.

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Narita, Vanny. "Molecular, genetic, and functional analysis of Ptr3p, a novel protein involved in amino acid and dipeptide regulation of di/tri-peptide transport system in Saccharomyces cerevisiae." 2002. http://etd.utk.edu/2002/NaritaVanny.pdf.

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Thesis (Ph. D.)--University of Tennessee, Knoxville, 2002.<br>Title from title page screen (viewed Oct. 3, 2002). Thesis advisor: Jeffrey M. Becker. Document formatted into pages (xiv, 250 p. : ill. (some col.)). Vita. Includes bibliographical references.

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Müllers, Nina. "Struktur-Funtionsbeziehung in den spleißosomalen Proteinen des U4/U6•U5 tri-snRNP." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-AC43-D.

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