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Journal articles on the topic ''-trimethoxyflavonc'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Goutam, Brahmachari, Gangopadhyay Arindam, K. Jash Shyamal, and Chandra Mondal Lalan. "5-Hydroxy-3, 7 ,4' -trimethoxyflavone from Cheilanthes farinosa Kaulf. (Cheilanthaceae)." Journal of Indian Chemical Society Vol. 85, May 2008 (2008): 546–47. https://doi.org/10.5281/zenodo.5816500.

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Natural Products Laboratory. Department of Chemistry, Visva-Bharati University, Santiniketan-731 235, West Bengal, India <em>E-mail :</em> brahmg2001@yahoo.co.in <em>Manuscript received 10 August 2007, revised 18 January 2008, accepted 21 January 2008</em> Cheilauthes fariuosa Kaulr. (Cheilauthaceae) has been established as new source of the natural flavonoid. 5- hydroxy-3, 7 ,4' -trimethoxyflavone, characterized on the basis of spectral studies.

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2

Krishnaiah, M., R. Ravi Kumar, N. Jagadeesh Kumar, D. Gunasekar, and B. Jayaprakasam. "5-Hydroxy-7,8,2′-trimethoxyflavone." Acta Crystallographica Section E Structure Reports Online 61, no. 9 (2005): o2862—o2864. http://dx.doi.org/10.1107/s1600536805024827.

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3

Gajhede, M., R. Encarnacion, G. C. Leal, J. C. Patino, C. Christophersen, and P. H. Nielsen. "5-Hydroxy-3,7,4'-trimethoxyflavone." Acta Crystallographica Section C Crystal Structure Communications 45, no. 12 (1989): 2012–14. http://dx.doi.org/10.1107/s0108270189008449.

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4

Xiong, Hui-Ping, Zhi-Jun Wu, Fa-Tang Chen, and Wan-Sheng Chen. "5,7-Dihydroxy-3,6,8-trimethoxyflavone." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (2009): o3276—o3277. http://dx.doi.org/10.1107/s1600536809050715.

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5

Lee, Sullim, Taesu Jang, Ki Hyun Kim, and Ki Sung Kang. "Improvement of Damage in Human Dermal Fibroblasts by 3,5,7-Trimethoxyflavone from Black Ginger (Kaempferia parviflora)." Antioxidants 11, no. 2 (2022): 425. http://dx.doi.org/10.3390/antiox11020425.

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Reactive oxygen species (ROS) are generated during intrinsic (chronological aging) and extrinsic (photoaging) skin aging. Therefore, antioxidants that inhibit ROS production may be involved in delaying skin aging. In this study, we investigated the potential effects of compounds isolated from black ginger, Kaempferia parviflora, a traditional medicinal plant, on normal human dermal fibroblasts in the context of inflammation and oxidative stress. The isolated compounds were structurally characterized as 5-hydroxy-7-methoxyflavone (1), 3,7-dimethoxy-5-hydroxyflavone (2), 5-hydroxy-3,7,3,4-tetram

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6

Ahmad, Muhammad Afiffikri, Nurulfazlina Edayah Rasol, Nurunajah Ab Ghani, Kamsirah Jim Shamsudin, and Monica Suleiman. "Flavonoids from the Borneo Plant Species: Eusideroxylon zwageri Teijsm. & Binn." Journal of Science and Mathematics Letters 11, no. 1 (2023): 39–42. http://dx.doi.org/10.37134/jsml.vol11.1.5.2023.

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A new flavonoid, 7,3ˊ-dihydroxy-3,5,4ˊ-trimethoxyflavone, along with two known flavonoids,7-hydroxy-5,4ˊ-dimethoxyflavone and 7-hydroxy-3,5,4ˊ-trimethoxyflavone were isolated from the leaves ethyl acetate extract of Eusideroxylon zwageri Teijsm. & Binn. (Lauraceae). Structures were elucidated by spectroscopic techniques such as NMR, IR, and Orbitrap Mass Spectrometry.

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7

Wang, Min, Guo-Bo Xu, Jun Liu, et al. "Buxusoside, a Flavonoid Disaccharide from Buxus sinica." Natural Product Communications 12, no. 4 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200416.

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A new flavonoid diglycoside named buxusoside (1), together with its aglycone chrysosplenol-D (2), as well as 4’, 5-dihydroxy-3,6,7-trimethoxyflavone (3) and 3’,4’,5-trihydroxy-3,6,7-trimethoxyflavone (4), were isolated from the 70% EtOH extract of the air-dried plant of Buxus sinica. Its structure was elucidated mainly by 1D and 2D NMR spectra.

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8

Ali, M. Shaiq, Shamsher Ali, Shazia Anjum, and Waqar Ahmad. "5-Hydroxy-4′,6,7-trimethoxyflavone." Acta Crystallographica Section E Structure Reports Online 62, no. 3 (2006): o1107—o1109. http://dx.doi.org/10.1107/s1600536806005617.

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9

Legoale, Percival B., Mahlori J. Mashimbye, and Teunis van Ree. "Antiinflammatory and Antioxidant Flavonoids from Helichrysum Kraussii and H. odoratissimum Flowers." Natural Product Communications 8, no. 10 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801015.

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Organic extracts of the flowers of Helichrysum kraussii and H. odoratissimum contain several bioactive flavonoids, characterized by 1H NMR, 13C NMR and mass spectrometry. Four flavonoids, 5,6-dihydroxy-3,7,8-trimethoxyflavone, 5,7-dihydroxy-3-methoxyflavone, 3′,4′,5,7-tetrahydroxy-3-methoxyflavone and 3′,4′,3,5-tetrahydroxy-7-methoxyflavone, have antioxidant activity by the DPPH free radical assay, while 5,6-dihydroxy-3,7,8-trimethoxyflavone and 3′,4′,3,5-tetrahydroxy-7-methoxyflavone have promising anti-inflammatory activity.

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10

Phan, Minh Giang, Thi Viet Huong Do, and Quoc Binh Nguyen. "Methylated Flavonols from Amomum koenigii J.F.Gmel. and Their Antimicrobial and Antioxidant Activities." Biochemistry Research International 2020 (February 18, 2020): 1–6. http://dx.doi.org/10.1155/2020/4812312.

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Methylated flavonols form a special group with modulating biological activities in comparison with kaempferol and quercetin. The present study isolated ten compounds including two kaempferol methyl ethers: 5-hydroxy-3,7,4′-trimethoxyflavone (1), 3-hydroxy-5,7,4′-trimethoxyflavone (6); four quercetin methyl ethers: retusin (5-hydroxy-3,7,3′,4′-tetramethoxyflavone) (4), 3,5-dihydroxy-7,3′,4′-trimethoxyflavone (5), 3,4′-dihydroxy-5,7,3′-trimethoxyflavone (7), and 3,5,7,3′,4′-pentamethoxyflavone (9); β-sitosterol (2); 5-hydroxy-1-(4′-hydroxyphenyl)eicosan-3-one (3); p-hydroquinone (8); and vanilli

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11

Smith, Graham, Ertong Wang, John P. Bartley, and Raymond C. Bott. "Pachypodol (4,5′-dihydroxy-3,3′,7-trimethoxyflavone)." Acta Crystallographica Section E Structure Reports Online 57, no. 10 (2001): o973—o975. http://dx.doi.org/10.1107/s1600536801015252.

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12

Hoi, Tran Minh, Tran Van Thai, Chu Thi Thu Ha, Ha Thi Van Anh, Phan Xuan Binh Minh, and Nguyen Tien Dat. "Flavonoids from Anoectochilus annamensis and their Anti-inflammatory Activity." Natural Product Communications 11, no. 5 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100514.

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One new flavonol diglycoside, 4′,5-dihydroxy-3,3′,7-trimethoxyflavone 4′- O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), and two known compounds (2–3) were isolated from the methanol extract of Anoectochilus annamensis Aver. aerial parts. The effects were evaluated of all isolated compounds (1–3) on LPS-induced production of the inflammatory mediator nitric oxide (NO) by RAW264.7 cells. 4′,5-Dihydroxy-3,3′,7-trimethoxyflavone (2) was the most active while the addition of a rutinoside at C-4′ (compound 1) decreased the inhibitory activity. This is the first report on the chemical composit

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13

Supian, Suhaina, Muhamad Aizuddin Ahmad, Lina Rozano, Machap Chandradevan, and Zuraida Ab Rahman. "Phyllanthus tenellus Roxb. and Kaempferia parviflora Wall. ex Baker compounds as inhibitors of SARS-CoV-2 main protease and RNA-dependent RNA polymerase: A molecular docking study." Journal of Pharmacy & Pharmacognosy Research 10, no. 6 (2022): 1103–16. http://dx.doi.org/10.56499/jppres22.1485_10.6.1103.

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Context: The outbreak of a novel coronavirus, SARS-CoV-2 has caused an unprecedented COVID-19 pandemic. To put an end to this pandemic, effective antivirals should be identified or developed for COVID-19 treatment. However, specific and effective antivirals or inhibitors against SARS-CoV-2 are still lacking. Aims: To evaluate bioactive compounds from Phyllanthus tenellus and Kaempferia parviflora as inhibitors against two essential SARS-CoV-2 proteins, main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), through molecular docking studies and to predict the drug-likeness properties of

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14

Ticona, Luis Apaza, Andreea Madalina Serban, Daly Apaza Ticona, and Karla Slowing. "Anti-inflammatory and Anti-arthritic Activities of Aqueous Extract and Flavonoids from Tripodanthus acutifolius Leaves in Mice Paw Oedema." Planta Medica International Open 8, no. 02 (2021): e43-e55. http://dx.doi.org/10.1055/a-1471-8947.

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Abstract Tripodanthus acutifolius, commonly known as Jamillo, is an herbal remedy used in traditional Andean medicine to treat joint problems, such as sprains, dislocations, and rheumatic pain. This study aimed to evaluate the in vitro and in vivo anti-inflammatory and anti-arthritic activity of the aqueous extract and isolated compounds of T. acutifolius. A bioguided phytochemical analysis based on NMR/MS was performed to identify the compounds of the aqueous extract from T. acutifolius. The anti-inflammatory and anti-arthritic activity were evaluated by measuring inflammatory parameters (TNF

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15

Uehara, Ayumi, Junichi Kitajima, Goro Kokubugata, and Tsukasa Iwashina. "Further Characterization of Foliar Flavonoids in Crossostephium chinense and their Geographic Variation." Natural Product Communications 9, no. 2 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900207.

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Foliar flavonoids of Crossostephium chinense in Japan and Taiwan were isolated and further characterized. Eighteen flavonoid aglycones, luteolin, apigenin, hispidulin, chrysoeriol, 5,7,4′-trihydroxy-6,3′,5′-trimethoxyflavone, jaceosidin, cilsimaritin, quercetin 3-methyl ether, axillarin, chrysosplenol-D, cirsiliol, apometzgerin, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, luteolin 3′,4′-dimethyl ether, cirsilineol, eupatilin, nepetin and 5,7,3′,4′-tetrahydroxy-6,5′-dimethoxyflavone, were identified by UV, 1H and 13C NMR spectroscopic, LC-MS and HPLC comparisons with authentic samples. The com

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16

Donbaeva, E. K., V. I. Yamovoi, B. I. Tuleuvov, K. M. Turdybekov, Yu V. Gatilov, and S. M. Adekenov. "Acetylation of 8-Bromo-5-hydroxy-6,7,4′-trimethoxyflavone." Russian Journal of General Chemistry 75, no. 6 (2005): 943–45. http://dx.doi.org/10.1007/s11176-005-0349-0.

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17

Nguyen, Phi Hung. "METHOXYFLAVONES FROM ORTHOSIPHON STAMINEUS BENTH. AND THEIR PTP1B INHIBITORY ACTIVITIES." Vietnam Journal of Science and Technology 56, no. 4A (2018): 146. http://dx.doi.org/10.15625/2525-2518/56/4a/12877.

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Phytochemical analysis of the methanol extract of the aerial parts of Orthosiphon stamineus Benth. led to the isolation of four flavone compounds including 5-hydroxy-3,7,3′,4′-tetramethoxyflavone (1), 3,5,7,3′,4′-pentamethoxyflavone (2), 3,3′-dihydroxy-5,7,4′-trimethoxyflavone (3), and 3,5,3′-trihydroxy-7,4ʹ-dimethoxyflavone (4). Their chemical structures were determined from the spectroscopic evidences, including 1D-NMR and MS, respectively. The inhibitory effects of the isolates (1‒4) against protein tyrosine phosphatase 1B (PTP1B) enzyme were investigated in vitro using ursolic acid as posi

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18

Habsaoui, Amar, José Luis Franquet Cami, Emile M. Gaydou, and Jean-Claude Wallet. "Demethylation-Sulfonation of 2',3',4'-Trimethoxyflavones." HETEROCYCLES 51, no. 8 (1999): 1905. http://dx.doi.org/10.3987/com-99-8546.

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19

Nakata, Asami, Yuka Koike, Hirofumi Matsui, Tsutomu Shimada, Masaki Aburada, and Jinwei Yang. "Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora." Natural Product Communications 9, no. 9 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900918.

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The SIRT1 enzyme-stimulating and anti-glycation activities of Kaempferia parviflora extract and its main polymethoxyflavonoids were evaluated in vitro. K. parviflora extract elevated SIRT1 catalytic activity by eight- and 17-fold at 20 μg/mL and 100 μg/mL, respectively, compared with vehicle only. Two major polymethoxyflavonoids, 3,5,7,3′,4′-pentamethoxyflavone (4) and 5,7,4′-trimethoxyflavone (5), were isolated from this extract and are four- and fivefold more potent than resveratrol, hitherto the strongest known natural SIRT1 activator. In addition, the anti-glycation activity of K. parviflo

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20

Díaz, Oscar, Rosana Alarcón, Diego Gutiérrez, Adriana Pacciaroni, Fany Cayo, and Virginia Sosa. "6-Methoxyflavonoids and Other Constituents from Microliabum polymnioides (Asteraceae)." Natural Product Communications 10, no. 7 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000712.

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The flower heads of Microliabum polymnioides afforded scopoletin, 5,4′-dihydroxy-3,6,7-trimethoxyflavone, 3,5,4′-trihydroxy-6,7-dimethoxyflavone and 3,5,7,4′-tetrahydroxy-6-methoxyflavone. The leaves contained hexadecanoic acid, phytol and docosane. This is the first report on the presence of 6-methoxy-flavonoids in Microliabum genus.

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21

Radhika, Parvataneni, Yejella Rajendra Prasad, and Koduru Rajya Lakshmi. "Flavones from the Stem of Andrographis paniculata Nees." Natural Product Communications 5, no. 1 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500115.

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Chemical investigation of Andrographis paniculata Nees (Acanthaceae) resulted in the isolation of three flavones identified as 5-hydroxy-7,8,2′-trimethoxyflavone 1, 5-hydroxy-7,8-dimethoxyflavone 2 and 5-hydroxy-7,8,2′,5′-tetramethoxyflavone 3 from the hexane, methanol and chloroform extracts of the root and stem.

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22

K., S. MUKHERJEE, BRAHMACHARI G., K. MANNA T., and MUKHERJEE P. "A New Flavone from Limnophila heterophylla." Journal of Indian Chemical Society Vol. 75, Apr 1998 (1998): 260–61. https://doi.org/10.5281/zenodo.5923997.

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Department of Chemistry, Visva-Bharati University, Santiniketan-731 235 Manuscript received 10 March 1997, revised 8 July 1997, accepted 12 August 1997 The benzene extract of the aerial parts and roots of Limnophila heterophylla yielded a new flavone, 5,2'-dihydroxy-7,8,4'- trimethoxyflavone.

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23

Elhady, Sameh S., Enas E. Eltamany, Amera E. Shaaban, et al. "Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies." Plants 9, no. 8 (2020): 1031. http://dx.doi.org/10.3390/plants9081031.

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Phytochemical study of Chiliadenus montanus aerial parts afforded six compounds; Intermedeol (1), 5α-hydroperoxy-β-eudesmol (2), 5,7-dihydroxy-3,3’,4’-trimethoxyflavone (3), 5,7,4’-trihydroxy-3,6,3’-trimethoxyflavone (jaceidin) (4), eudesm-11,13-ene-1β,4β,7α-triol (5) and 1β,4β,7β,11-tetrahydroxyeudesmane (6). These compounds were identified based on their NMR spectral data. The isolated compounds were tested for their cytotoxicity against liver cancer cell line (HepG2) and breast cancer cell line (MCF-7). Jaceidin flavonoid (4) exhibited the highest cytotoxic effect in vitro. Therefore, both

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24

Prayoga, Tria, Deni Rahmat, Ni Made Dwi Sandhiutami, and Yesi Desmiaty. "ANALISIS PREDIKSI EFEK ANTIINFLAMASI PADA PIPER PORPHYROPHYLLUM SECARA IN SILICO." JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi dan Kesehatan 10, no. 1 (2025): 30–40. https://doi.org/10.36387/jiis.v9i2.2352.

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This study aims to predict the anti-inflammatory effects of compounds in Piper porphyrophyllum using in silico methods. The compounds were analyzed using AutoDock software to evaluate their binding potential with the target protein and Lipinski's rule of five to assess their drug-likeness based on pharmacokinetic properties. Qualitative results show that compounds such as 4'-hydroxy-3',5,7-trimethoxyflavone, 4',5-dihydroxy-3',7-dimethoxyflavone, and 5-hydroxy-3',4',7-trimethoxyflavone form significant interactions with key residues on the target protein. Quantitatively, these compounds exhibit

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25

Yu, Quan-Lin, Hong-Quan Duan, and Wen-Yuan Gao. "3-Hydroxy-5,7,4′-trimethoxyflavone monohydrate from Cucubalus baccifier (L.)." Acta Crystallographica Section E Structure Reports Online 62, no. 7 (2006): o2910—o2911. http://dx.doi.org/10.1107/s1600536806022392.

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The title compound, C18H16O6·H2O, is a flavonol which was isolated from Cucubalus baccifer (L.). Intermolecular O—H...O and C—H...O hydrogen bonds link the molecules to form networks stacked along the a axis.

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26

N. A., Noor Camellia,, Nora’ini, A., Izlamira, R., Mirfat, A. H. S., Ahmad Arif, I., and Yaseer, S. "The Impact of 6-Benzylaminopurine (BAP) on Plant Growth, Micro-rhizome Induction and Phytochemical Content of Black Ginger (Kaempferia parviflora) Using Two In-vitro Culture System." Journal of Advances in Biology & Biotechnology 28, no. 2 (2025): 526–36. https://doi.org/10.9734/jabb/2025/v28i22013.

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This study investigates the impact of 6-Benzylaminopurine (BAP) on shoot multiplication, micro-rhizome induction, and 5,7,4-trimethoxyflavone content in Kaempferia parviflora, commonly known as kunyit hitam or black ginger. Explants were cultivated using two culture systems, conventional semi-solid medium and the temporary immersion system (RITA®) with varying BAP concentrations (0 to 7.5 mg/L). Results revealed that BAP concentration significantly influenced shoot and root development. Optimal shoot proliferation was achieved at 2.5 mg/L BAP, while root growth decreased at higher concentratio

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27

Harder, Lene H., and Lars P. Christensen. "A New Flavone O-Glycoside and Other Constituents from Wheat Leaves (Triticum aestivum L.)." Zeitschrift für Naturforschung C 55, no. 5-6 (2000): 337–40. http://dx.doi.org/10.1515/znc-2000-5-607.

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From leaves of Triticum aestivum a new O-glycosylflavone has been isolated together with chlorogenic acid and its 3′-methyl ether and 6 C-glycosylflavones. The structure of the new flavonoid was determined by 1D and 2D NMR techniques and other spectral evidence as 5,7-dihydroxy-3′,4′,5′-trimethoxyflavone-7-O-β-rutinoside.

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28

Hussain, Javid, Naeema Begum, Hidayat Hussain, et al. "Ajuganane: A New Phenolic Compound from Ajuga bracteosa." Natural Product Communications 7, no. 5 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700518.

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Phytochemical investigation of Ajuga bracteosa Wall ex Benth. (Labiatae) resulted in the isolation of a new phenolic compound, ajuganane (1) and three known compounds, 3,4′-dihydroxy-3,6,7-trimethoxyflavone, 7-hydroxy-3,6,3′,4′-tetramethoxyflavone and ursolic acid. The structure of the new compound was elucidated by detailed spectroscopic (1H, 13 C NMR, COSY, HMQC, HMBC), and HR-EI-MS analysis.

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29

Filho, Abrahão, Heloísa Fernandes, Janiere Sousa, et al. "Antifungal Effect of Flavonoid 5,7,4’-Trimethoxyflavone against Candida krusei Strains." International Journal of TROPICAL DISEASE & Health 5, no. 2 (2015): 136–40. http://dx.doi.org/10.9734/ijtdh/2015/14060.

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30

Habsaoui, A., Ε. M. Gaydou, and J. C. Wallet. "Crystal structure of 6-hydroxy-2',3',4'-trimethoxyflavone, C18H16O6." Zeitschrift für Kristallographie - New Crystal Structures 214, no. 4 (1999): 465–66. http://dx.doi.org/10.1515/ncrs-1999-0433.

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31

Murray, Iain A., Colin A. Flaveny, Brett C. DiNatale, et al. "Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2′,4′-Trimethoxyflavone." Journal of Pharmacology and Experimental Therapeutics 332, no. 1 (2009): 135–44. http://dx.doi.org/10.1124/jpet.109.158261.

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32

Wallet, J. C., and V. Cody. "A New Polymorph of 7-Hydroxy-2',3',4'-trimethoxyflavone." Acta Crystallographica Section C Crystal Structure Communications 51, no. 6 (1995): 1193–95. http://dx.doi.org/10.1107/s0108270194005986.

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33

Yang, Ai Mei, Wei Jie Guo, Yan Zeng, Hong Fei Gong, and Rui Wu. "Chemical Constituents from Cremanthodium potaninii." Advanced Materials Research 852 (January 2014): 8–11. http://dx.doi.org/10.4028/www.scientific.net/amr.852.8.

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Ten compounds were isolated from the ethol extract of the whole plant of Cremanthodium potaninii. Stigmasterol (1), β-sitosterol (2), triacontane (3), 5,6-dihydroxy-3,4,7-trimethoxyflavone (4), 5,6,7-trihydroxy-3,4-dimethoxyflavone (5), 6-hydroxy-7-methoxycoumarin (6), taraxasterol (7), caffeic acid (8),hexacosoic acid (9),triacontanoic acid (10). All these compounds were isolated from Cremanthodium potaninii for the first time.

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34

Budzianowski, Jaromir, and Eckhard Wollenweber. "Rare Flavones from the Glandular Leaf Exudate of the Oxlip, Primula Elatior L." Natural Product Communications 2, no. 3 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200308.

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5,6,2′,3′,6′-Pentamethoxyflavone (1), together with 3′,5′-dihydroxy-4′-methoxyflavone (2), 2′-methoxyflavone, 3′-methoxyflavone, 3′,4′-dimethoxyflavone, 2′,5′-methoxyflavone, 3′-hydroxy-4′,5′-dimethoxyflavone, 3′,4′,5′-trimethoxyflavone, and 3′-hydroxy-4′,5′-methylenedioxyflavone were found in the leaf exudate of the oxlip, Primula elatior (Primulaceae). The structures of flavones 1 and 2 were substantiated by 2D NMR spectroscopy.

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35

Klinngam, Wannita, Phetploy Rungkamoltip, Ratjika Wongwanakul, et al. "Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial." Biomolecules 14, no. 7 (2024): 776. http://dx.doi.org/10.3390/biom14070776.

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Polymethoxyflavones from Kaempferia parviflora rhizomes have been shown to effectively combat aging in skin cells and tissues by inhibiting senescence, reducing oxidative stress, and enhancing skin structure and function. This study assessed the anti-aging effects and safety of standardized K. parviflora extract (BG100), enriched with polymethoxyflavones including 5,7-dimethoxyflavone, 5,7,4’-trimethoxyflavone, 3,5,7,3’,4’-pentamethoxyflavone, 3,5,7-trimethoxyflavone, and 3,5,7,4ʹ-tetramethoxyflavone. We evaluated BG100’s impact on skin rejuvenation and antioxidant properties using photoaged h

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36

Suhaimi, M. Yaseer, M. S. Rosalizan, and A. H. S. Mirfat. "Effects of Organic Growing Media on Growth, Yield and Bioactive Compound of Black Ginger (Kaempferia parviflora) Cultivated using Soilless Culture." Asian Research Journal of Agriculture 17, no. 3 (2024): 159–67. http://dx.doi.org/10.9734/arja/2024/v17i3484.

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The experiment, conducted under a side-netted rain shelter, holds promise for the future of black ginger cultivation. Five mixtures of organic growing media were evaluated: 100% coco peat; 100% rice husk ash; 70% coco peat + 30% rice husk ash; 30% coco peat + 70% rice husk ash; and 50% coco peat + 50% rice husk ash. The black ginger rhizomes were harvested eight months after planting. The plants grown in 50% coco peat + 50% rice husk ash mixtures showed the best growth performance and yield, producing the highest vegetative fresh weight shoot height (678 g) and rhizome yield (582 g per plant).

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37

Habsaoui, Amar, Jose Luis Franquet Cami, Emile M. Gaydou, and Jean-Claude Wallet. "ChemInform Abstract: Demethylation-Sulfonation of 2′,3′,4′-Trimethoxyflavones." ChemInform 30, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199945158.

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Sookkhee, Siriwoot, Choompone Sakonwasun, Pitchaya Mungkornasawakul, Phadungkiat Khamnoi, Nitwara Wikan, and Wutigri Nimlamool. "Synergistic Effects of Some Methoxyflavones Extracted from Rhizome of Kaempferia parviflora Combined with Gentamicin against Carbapenem-Resistant Strains of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii." Plants 11, no. 22 (2022): 3128. http://dx.doi.org/10.3390/plants11223128.

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The present study aimed to investigate the antibacterial activity of ethanolic Kaempferia parviflora extracts and the combined effects of the plant’s specific compounds with gentamicin against clinical strains of carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. The minimal inhibitory concentrations (MIC) of gentamicin and Kaempferia parviflora extracts against the tested bacterial strains were determined by using broth microdilution. The combined effects of Kaempferia parviflora extract and gentamicin were investigated by using a checkerboard ass

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39

Kisiel, Wanda, Anna Stojakowska, Franco Piozzi, and Sergio Rosselli. "Flavonoids from Teucrium fruticans L." Acta Societatis Botanicorum Poloniae 70, no. 3 (2014): 199–201. http://dx.doi.org/10.5586/asbp.2001.025.

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From aerial parts of <em>Teucrium fncticans</em> L. three flavonoids were isolated and identified as 5-hydroxy-6, 7, 3', 4'-tetramethoxyflavone, 5, 4'-dihydroxy-6, 7, 3'-trimethoxyflavone (cirsilineol) and 5, 4'-dihydroxy-6, 7-dimethoxyflavone (cirsimaritin). The former compound was found to be a predominant flavone aglycone constituent of the plant material. This is the first report on the isolation of flavonoids from the plant.

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40

Jassbi, Amir Reza, Simin Zamanizadehnajari, Parviz Aberoomand Azar, and Satoshi Tahar. "Antibacterial Diterpenoids from Astragalus brachystachys." Zeitschrift für Naturforschung C 57, no. 11-12 (2002): 1016–21. http://dx.doi.org/10.1515/znc-2002-11-1211.

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Antibacterial bioassay guided fractionation of acetone extracts of Astragalus brachystachys resulted in isolation of sclareol and two related labdane-type diterpenoids, 14R-epoxysclareol and 6β-hydroxysclareol. The antibacterial activity of the isolated compounds was measured and it was deduced that the epoxidation at the double bond of sclareol or hydroxylation at C-6 decreased the activity of the resulting compounds. Salvigenin (5-hydroxy-4′,6,7-trimethoxyflavone) was also separated from this plant for the first time.

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41

Huo, Chen, Sullim Lee, Min Jeong Yoo, et al. "Methoxyflavones from Black Ginger (Kaempferia parviflora Wall. ex Baker) and their Inhibitory Effect on Melanogenesis in B16F10 Mouse Melanoma Cells." Plants 12, no. 5 (2023): 1183. http://dx.doi.org/10.3390/plants12051183.

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Kaempferia parviflora Wall. ex Baker (Zingiberaceae), commonly known as Thai ginseng or black ginger, is a tropical medicinal plant in many regions. It has been traditionally used to treat various ailments, including ulcers, dysentery, gout, allergies, abscesses, and osteoarthritis. As part of our ongoing phytochemical study aimed at discovering bioactive natural products, we investigated potential bioactive methoxyflavones from K. parviflora rhizomes. Phytochemical analysis aided by liquid chromatography–mass spectrometry (LC-MS) led to the isolation of six methoxyflavones (1–6) from the n-he

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42

Sakuludomkan, Chotiwit, Jittasak Khowsathit, Pilaiporn Thippraphan, Nut Koonrungsesomboon, Mingkwan Na Takuathung, and Weerakit Taychaworaditsakul. "Network Pharmacology and Molecular Docking-Based Approach to Explore Potential Bioactive Compounds from Kaempferia parviflora on Chemokine Signaling Pathways in the Treatment of Psoriasis Disease." International Journal of Molecular Sciences 26, no. 11 (2025): 5243. https://doi.org/10.3390/ijms26115243.

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Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation and dysregulated chemokine signaling. Kaempferia parviflora (KP) has long been valued for its medicinal properties; however, its specific role in psoriasis treatment remains unclear. This study investigates the anti-psoriatic potential of methoxyflavones derived from KP through an integrated approach combining network pharmacology, molecular docking, and experimental validation. A total of 232 target genes were identified as being associated with KP bioactive compounds, of which 64 overlapped wit

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43

Tri, Mai Dinh. "Phân lập một số hợp chất từ thân rễ ngải tím (Kaempferia parviflora Wall. Ex Baker), họ gừng (Zingiberaceae)". Can Tho University Journal of Science 57, № 1 (2021): 45–50. http://dx.doi.org/10.22144/ctu.jvn.2021.007.

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Năm hợp chất bao gồm 5,7-dimethoxyflavone (1), 3,5,7-trimethoxyflavone (2), di-O-methylpinocembrin (3), bisdemethoxycurcumin (4), aloe-emodin (5) được phân lập từ dịch chiết n-hexane thân rễ Ngải tím Kaempferia parviflora (họ Gừng). Cấu trúc hóa học các hợp chất được xác định bằng các phương pháp phổ nghiệm kết hợp với so sánh cấu trúc với tài liệu tham khảo. Trong đó các hợp chất phân lập 4, 5 lần đầu tìm thấy trong loài Kaempferia parviflora

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SUNIL, K. TALAPATRA, POLLEY MALABIKA, and TALAPATRA BANI. "Calliphyllin, a New Diterpene from the Leaves of Callicarpa macrophylla." Journal of Indian Chemical Society Vol. 71, June-Aug 1994 (1994): 527–32. https://doi.org/10.5281/zenodo.5896022.

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Centre of Advanced Studies on Natural Products, Department of Chemistry, University College of Science, Calcutta-700 009 <em>Manuscript received March 31, 1994</em> A new diterpene designated calliphyllin, betulinic acid, 5,4'-dihydroxy-3,7,3'-trimethoxyflavone, 5,4'-dihydroxy-3,7-dimethoxyflavone and β-sitosterol have been isolated from the leaves of <em>Callicarpa macrophylla Vahl.</em> (Verbenaceae). Calliphyllin has been shown to possess 14α-hydroxy-isopimaric acid (1) structure on the basis of nmr and mass spectral and chemical evidence.

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45

Tep-areena, P., and P. Sawasdee. "Vasorelaxant Effects of 5,7,4’-Trimethoxyflavone from Kaepmferia parviflora in the Rat Aorta." International Journal of Pharmacology 6, no. 4 (2010): 419–24. http://dx.doi.org/10.3923/ijp.2010.419.424.

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46

Jang, H., E. Jeong, S. Kim, et al. "5,7-Dihydroxy-3,4,6-Trimethoxyflavone Protects Kidneys From Ischemia-Reperfusion Injury in Mice." Transplantation 98 (July 2014): 352. http://dx.doi.org/10.1097/00007890-201407151-01140.

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47

Kim, J. Y., S. S. Kim, H. J. Jang, et al. "5,7-Dihydroxy-3,4,6-Trimethoxyflavone Attenuates Ischemic Damage and Apoptosis in Mouse Islets." Transplantation Proceedings 47, no. 4 (2015): 1073–78. http://dx.doi.org/10.1016/j.transproceed.2014.12.049.

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48

Wollenweber, Eckhard, Ingrid Schober, Pia Dostal, Dagmar Hradetzky, Francisco J. Arriaga-Giner, and George Yatskievych. "Flavonoids and Terpenoids from the Exudates of Some Baccharis Species." Zeitschrift für Naturforschung C 41, no. 1-2 (1986): 87–93. http://dx.doi.org/10.1515/znc-1986-1-214.

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Abstract Seven species of the genus Baccharis have been analyzed for flavonoid aglycones. Many known methylated flavones, flavonols and flavanones were identified. From B. sarothroides, two novel flavonols were isolated and elucidated as 5,7,4′-trihydroxy-3,6,8-trimethoxyflavone and its methyl ether, 5,4′-dihydroxy-3,6,7,8-tetramethoxyflavone. Previous literature reports on flavonoids in Baccharis are summarized and their distribution and external occurrence is discussed. One novel diterpene and one rare triterpene were found in the terpenoid fractions that constitute most of the exudate mater

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49

Popoola, Olugbenga K., Jeanine L. Marnewick, Emmanuel I. Iwuoha, and Ahmed A. Hussein. "Methoxylated Flavonols and ent-Kaurane Diterpenes from the South African Helichrysum rutilans and Their Cosmetic Potential." Plants 12, no. 15 (2023): 2870. http://dx.doi.org/10.3390/plants12152870.

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Chromatographic fractionation of a methanol extract of Helichrysum rutilans afforded seven known compounds. The isolated compounds were identified as 5,7,8-trihydroxy-3,6-dimethoxyflavone-8-O-2-methyl-2-butanoate (C-1), 5,7-dihydroxy-3,6,8-trimethoxyflavone (C-2), 5-hydroxy-3,6,7,8-tetramethoxyflavone (C-3), 5-hydroxy-3,6,7-trimethoxyflavone (C-4), ent-kaurenoic acid (C-5), ent-kauran-18-al (C-6), and 15-α-hydroxy-(-)-ent-kaur-16-en-19-oic acid (C-7). Compounds C-1–C-4 demonstrated high antioxidant capacities on ORAC hydroxyl radical (2.114 ± 4.01; 2.413 ± 6.20; 1.924 ± 16.40; 1.917 ± 3.91) ×

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50

Perez G, R. M., H. Cervantes C., M. A. Zavala S., J. Sanchez A., S. Perez G., and C. Perez G. "Isolation and hypoglycemic activity of 5, 7,3′-trihydroxy-3,6,4′-trimethoxyflavone from Brickellia veronicaefolia." Phytomedicine 7, no. 1 (2000): 25–29. http://dx.doi.org/10.1016/s0944-7113(00)80018-5.

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