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Journal articles on the topic 'Trinity Church (Philadelphia, Pa.)'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Morris, Stephanie. "St. Peter Claver Church and School, Philadelphia, PA: A Collaborative Effort." American Catholic Studies 128, no. 1 (2017): 101–13. http://dx.doi.org/10.1353/acs.2017.0010.

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Loewe, William P. "Jesus Christ in Modern Thought. By John Macquarrie. Philadelphia, PA: Trinity Press, 1990. x + 454 pages. $29.95." Horizons 19, no. 1 (1992): 139–41. http://dx.doi.org/10.1017/s0360966900025846.

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3

Lewis, James W. "Christ Church, Philadelphia: The Nation's Church in a Changing City. By Deborah Mathias Gough. Philadelphia, Pa.: University of Pennsylvania Press, 1995. xxiv + 425 pp. $29.95 cloth; $14.95 paper." Church History 65, no. 3 (1996): 550–52. http://dx.doi.org/10.2307/3170023.

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Sachs, William L. "A Brief History of the Episcopal Church. By David Holmes. Valley Forge, Pa.: Trinity Press, 1993. xv + 239 pp." Church History 65, no. 2 (1996): 329–31. http://dx.doi.org/10.2307/3170353.

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Gautom, Priyanka, Jamie H. Thompson, Cheryl A. Johnson, Jennifer S. Rivelli, and Gloria D. Coronado. "Abstract A102: Developing faith-based messaging and materials for colorectal cancer screening: Application of boot camp translation within the African Methodist Episcopal Church." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): A102. http://dx.doi.org/10.1158/1538-7755.disp22-a102.

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Abstract Introductory sentences: We use boot camp translation (BCT), a validated community based participatory strategy, to elicit input from African Methodist Episcopal (AME) congregants, leadership, and healthcare systems in Atlanta, Georgia to create culturally appropriate and locally relevant colorectal cancer (CRC) faith-based screening messages and materials for AME church communities. Brief description of pertinent experimental procedures: In the United States, CRC is the third-leading cause of cancer death and disproportionately impacts African Americans, highlighting the need for time

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Kornilov, Alexandr. "Educator S. N. Bogolyubov and his remarks about the parish schools of the Russian Orthodox Church in the states of New York and Pennsylvania (1962—1968)." INTELLIGENTSIA AND THE WORLD, no. 3 (October 1, 2020): 115–28. http://dx.doi.org/10.46725/iw.2020.3.7.

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The article studies publications of Semyon Nikolayevich Bogolyubov, 1889—1971, an outstanding educator of Russian Abroad. These publications were devoted to his trips to parish schools of the Russian Church Abroad (ROCOR). The educator S. N. Bogolyubov served in the 1960s as Chief Clerk of the Educational Council under Synod of Bishops of the Russian Church Abroad. In order to maintain effective control over and to improve learning process the teacher visited a few parish schools in 1962—1968. In particular, he visited such famous parishes in the states of New York and Pennsylvania as the Holy

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Metcalfe, Kyle S., Benjamin J. Krajacich, Xiaodong Qi, et al. "Abstract 4080: A novel integrated target capture and rapid sequencing workflow for myeloid malignancy mutation detection within 12 hours." Cancer Research 85, no. 8_Supplement_1 (2025): 4080. https://doi.org/10.1158/1538-7445.am2025-4080.

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Abstract Hybrid capture technology is a powerful and cost-effective tool in precision oncology research to detect somatic mutations in hematologic malignancies. While target capture is important for efficient mutation detection, obtaining rapid sequencing results is critical for research in this field. Traditional hybrid capture workflows involve several time-consuming steps prior to sequencing, including post-hybridization capture, washes, and amplification, which can delay results. Here, we combine Trinity™ hybrid capture and a rapid AVITI™ sequencing protocol to deliver targeted sequencing

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8

Walter, Katherine Clark. "Dyan Elliott, The Corrupter of Boys: Sodomy, Scandal, and the Medieval Clergy. The Middle Ages Series. Philadelphia, PA: University of Pennsylvania Press, 2020, 378 p." Mediaevistik 34, no. 1 (2021): 297–300. http://dx.doi.org/10.3726/med.2021.01.30.

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A perpetual problem in church history is ecclesiastics setting the bar too high for human success: compulsory celibacy, sought because Church leaders believed it preserved priests’ purity and status, inevitably led to problems that threatened both sacerdotal purity and clerical prestige. In The Corrupter of Boys, Dyan argues that clerical discipline settled on openly punishing clerics’ transgressions with women rather than correcting the “unnamable vice” of sodomy among men and boys. The relegation of sodomy to the realm of the unmentionable had the additional consequence that clerics repeated

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9

Breeze, Andrew. "Joel D. Anderson, Reimagining Christendom: Writing Iceland’s Bishops into the Roman Church, 1200–1350. Philadelphia, PA: University of Pennsylvania Press, 2023, viii, 240 pp." Mediaevistik 36, no. 1 (2023): 411–12. http://dx.doi.org/10.3726/med.2023.01.83.

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Two presences meet here. First is Iceland, with its black cliffs and bleak vistas; second, the Latin Church, with its rituals and law. In conjunction, they bring about a unique and stimulating monograph.

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10

Hall, Douglas John, and Rhoda Palfrey Hall. "The Sense of a People: Toward a Church for the Human Future; By Lewis S. Mudge Philadelphia, Trinity Press International, 1992. 258 pp. $17.95." Theology Today 50, no. 2 (1993): 306–10. http://dx.doi.org/10.1177/004057369305000219.

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11

Schweitzer, Don. "Comptes rendus / Reviews of books: Re-creating the Church: Communities of Eros Pamela Dickey Young Harrisburg, PA: Trinity Press International, 2000. x + 158 p." Studies in Religion/Sciences Religieuses 30, no. 2 (2001): 240–42. http://dx.doi.org/10.1177/000842980103000215.

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12

Marsden, George M. "Fighting the Good Fight: A Brief History of the Orthodox Presbyterian Church. By D. G. Hart and John Muether. Philadelphia, Pa.: Orthodox Presbyterian Church, 1995. 217 pp. $11.95." Church History 65, no. 4 (1996): 771–73. http://dx.doi.org/10.2307/3170474.

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13

Classen, Albrecht. "Elizabeth Allen, Uncertain Refuge: Sanctuary in the Literature of Medieval England. The Middle Ages Series. Philadelphia, PA: University of Pennsylvania Press, 2021, ix, 311 pp., 10 b/w ill." Mediaevistik 36, no. 1 (2023): 302–4. http://dx.doi.org/10.3726/med.2023.01.31.

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The topic of the sanctuary pursued by Elizabeth Allen invites critical examinations of the relationship between the secular and the spiritual authorities in the Middle Ages and beyond. The desperate desire of a condemned fellow about to be executed or of a group of people facing nearly certain death to find sanctuary in a church, at a cross, a saint’s grave, or simply at the feet of a bishop was a source of much debate. If sanctuary was granted, then divine laws overruled worldly laws, and it pitted the representatives of the Church against the king, the royal court, or the legal courts. But a

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Rushing, Scott. "Kissing Christians: Ritual and Community in the Late Ancient Church. By Michael Philip Penn. Philadelphia, PA: University of Pennsylvania Press, 2005. $42.50." Medieval Encounters 16, no. 2-4 (2010): 373–75. http://dx.doi.org/10.1163/157006710x497814.

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Carter, Brian J., Tzuan A. Chen, Dalnim Cho, Lorna H. McNeill, Shahnjayla K. Connors, and Lorraine R. Reitzel. "Abstract A099: Black church-goers who most recently sought cancer information from certain sources are less likely to have ever undergone colorectal cancer screening and thus less likely to benefit from early detection." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): A099. http://dx.doi.org/10.1158/1538-7755.disp22-a099.

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Abstract Purpose: Black adults have the highest colorectal cancer (CRC) incidence and mortality rates of any racial group in America. Early detection through CRC screening may improve survival outcomes; however, CRC screening uptake is lower for Black adults than White adults. To uncover opportunities to address these inequities, we examine where Black adults prefer to obtain cancer information, where they most recently sought such information, and whether either was associated with CRC screening behavior. Methods: Participants were a convenience sample of Black men and women recruited from 3

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Drell, Joanna H. "Florence and Its Church in the Age of Dante. By George W. Dameron. (Philadelphia, Pa.: University of Pennsylvania Press, 2005. Pp.x, 374. $65.00.)." Historian 70, no. 4 (2008): 828–29. http://dx.doi.org/10.1111/j.1540-6563.2008.00227_52.x.

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Mitchell, Stacy, and Karen Basen-Engquist. "Abstract B057: Addressing health disparities: Success of African American cancer survivors in the 'Active Living After Cancer' program and the role of Project CHURCH Partnership." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): B057. http://dx.doi.org/10.1158/1538-7755.disp24-b057.

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Abstract Purpose: The objective of this study was to explore the experience of African American cancer survivors participating in Active Living After Cancer (ALAC), a 12-session community-based physical activity program for cancer survivors. We will assess the ALAC program and Project CHURCH partnership, both administered through University of Texas MD Anderson Cancer Center's Health Disparities Research Department, and it’s aims to improve physical activity and physical functioning among African American cancer survivors. Background: Increasing evidence has shown that physical activity improv

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Sachs, William L. "Yet with a Steady Beat: The African American Struggle for Recognition in the Episcopal Church. By Harold T. Lewis. Valley Forge, Pa.: Trinity Press International, 1996. x + 253 pp. $18.00." Church History 66, no. 3 (1997): 674–75. http://dx.doi.org/10.2307/3169557.

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19

Segerstrom, Suzanne, and Edward Kasarskis. "BIOPSYCHOSOCIAL NATURAL HISTORY OF ALS: INTRODUCTION TO THE OPEN DATA, ACCESS, AND USE." Innovation in Aging 8, Supplement_1 (2024): 830. https://doi.org/10.1093/geroni/igae098.2689.

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Abstract The Seattle Amyotrophic Lateral Sclerosis (ALS) Patient Profile Database is a rich longitudinal dataset of ALS patients (n = 143; ages 26-83 years) and their partners (spouses, significant others, or caregivers; n = 123; ages 20-79 years) from clinics in Seattle, WA; San Francisco, CA; and Philadelphia, PA. The purpose of the study was to characterize the psychosocial and physical natural history of ALS and the interactions between them. Participants and partners (84% spouses) were separately interviewed in their homes every 3 months for up to 18 months between March 1987 and August 1

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Saloustros, Emmanouil, Christos Christodoulou, Flora Zagouri, et al. "Abstract P1-05-09: High prevalence of germline BRCA1/2 pathogenic variants in TNBC patients who achieve pCR: results from the TRINITY study." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–05–09—P1–05–09. https://doi.org/10.1158/1557-3265.sabcs24-p1-05-09.

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Abstract Background: Several reports indicate that over 15% of triple negative breast cancer (TNBC) patients harbor germline BRCA1/2 pathogenic variants (PV). BRCA-associated cancers have distinct characteristics that may result in higher pathologic complete response (pCR) rates after neoadjuvant chemotherapy (NACT). We hypothesized that the population of TNBC patients who achieve pCR may be enriched with germline BRCA1/2 PV. Methods: TRINITY is a retrospective, multicenter study, that enrolled patients with stage II–III TNBC who underwent surgery in Greece between 2016 and 2022. In this repor

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Han, Chen, and Heng Li. "Ruth Church, Martha Alibali & Spencer Kelly (eds.), Why gesture: How the hands function in speaking, thinking and communicating. Philadelphia, PA: John Benjamins, 2017. Pp. vii + 433." Journal of Linguistics 56, no. 2 (2020): 441–45. http://dx.doi.org/10.1017/s0022226720000031.

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Berman, Constance H. "Clare of Assisi and the Thirteenth-Century Church: Religious Women, Rules, and Resistance. By Catherine M. Mooney. (Philadelphia, PA: University of Pennsylvania Press, 2016. Pp. 291. $65.00.)." Historian 80, no. 2 (2018): 445–46. http://dx.doi.org/10.1111/hisn.12897.

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Miller, Tanya Stabler. "Clare of Assisi and the Thirteenth-Century Church: Religious Women, Rules, and Resistance. By Catherine M. Mooney. (Philadelphia, PA: University of Pennsylvania Press, 2016. Pp. 312. $65.00.)." Historian 80, no. 4 (2018): 850–52. http://dx.doi.org/10.1111/hisn.13045.

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Wiewora, Nathaniel. "Founding the Fathers: Early Church History and Protestant Professors in Nineteenth‐Century America. By Elizabeth A. Clark. (Philadelphia, Pa.: University of Pennsylvania Press, 2011. Pp. 561. $69.95.)." Historian 74, no. 2 (2012): 345–46. http://dx.doi.org/10.1111/j.1540-6563.2012.00322_11.x.

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Suragh, Tiffany, Lorna H. McNeill, and Nga Nguyen. "Abstract B043: Is pain preventing African Americans from reducing their cancer risk?" Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): B043. http://dx.doi.org/10.1158/1538-7755.disp22-b043.

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Abstract Introduction: The purpose of this study is to describe the prevalence of bodily pain and its association with cancer prevention and risk reducing lifestyle factors among African Americans. Background: Bodily pain can impact an individual’s psychological, physical and socioeconomic well-being and studies have shown that African Americans have a higher prevalence of reporting bodily pain. Additionally, African Americans report a higher prevalence of modifiable cancer risk factors, such as physical inactivity and obesity. We sought to examine the association between physical activity, se

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Gresham, Gillian, Christie Y. Jeon, Dong Hee Kim, et al. "Abstract CT272: A cluster randomized trial to evaluate a church-based navigation model to increase breast cancer screening in Korean women (Faith In Action!): Trial in progress." Cancer Research 84, no. 7_Supplement (2024): CT272. http://dx.doi.org/10.1158/1538-7445.am2024-ct272.

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Abstract Background: Breast cancer is the most commonly diagnosed cancer among Korean American women and incidence in this group is rising. Advanced-stage disease is more frequent among Korean women diagnosed with breast cancer than in other ethnicities due to low adherence to screening. Lower socioeconomic status, cultural barriers, perceived norm, distrust of healthcare system, and lack of awareness and culturally tailored communication on benefits of screening contribute to low screening utilization. Church settings offer important platforms for education as a majority of Korean American wo

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Padilla, Monica J., and Gregory Karczmar. "Abstract 1941: Barriers and effective interventions to engage Latinas' participation in breast cancer clinical trials." Cancer Research 83, no. 7_Supplement (2023): 1941. http://dx.doi.org/10.1158/1538-7445.am2023-1941.

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Abstract Breast cancer is the most diagnosed cancer among Latina women and is the leading cause of cancer-related death among Latinas (16.6%). While The Latino population is one of the fastest-growing populations in the US, they are severely underrepresented in clinical trials. Latinos make up 17% of the population but only 1% of clinical trial participants. Of clinical trials published covering 2001-2010, Latinos’ enrollment constituted only 2.2% of accrued participants. The percentage of Latino participants narrows down when we separate by gender. The goal of this study is to examine the pre

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Dwyer, James A. "A Requiem for Hitler and Other New Perspectives on the German Church Struggle. By Klaus Scholder. Translated by John Bowden. London and Philadelphia: SCM Press and Trinity Press International, 1989. xviii + 203 pp. $15.95 paper." Church History 62, no. 1 (1993): 149–50. http://dx.doi.org/10.2307/3168454.

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Rosado-Tristani, Diego A., Carlos S. Morales, Esther A. Peterson, and Jose A. Rodríguez-Martínez. "Abstract 2275: Transcription factor landscape cataloguing highlights key insights in inflammatory breast cancer (IBC)." Cancer Research 82, no. 12_Supplement (2022): 2275. http://dx.doi.org/10.1158/1538-7445.am2022-2275.

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Abstract Transcription factors are proteins that bind to DNA in a sequence-specific manner to regulate gene expression for normal cellular functions. Cancers have been shown to have aberrant transcriptional regulation. Therefore, identifying transcription factor landscapes will aid in characterizing complex diseases. As an example, breast cancer has many subtypes that are phenotypically and molecularly distinct. Inflammatory Breast Cancer (IBC) is rare, and the most aggressive form of breast cancer currently known. It is a poorly characterized subtype, and diagnosis often results in poor progn

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Lee, Che Young, Thuan Le, Carrie R. Daniel, et al. "Abstract B053: A pilot study of a digital weight loss program for cancer prevention among obese individuals from four diverse cohorts." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): B053. http://dx.doi.org/10.1158/1538-7755.disp24-b053.

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Abstract Background: Obesity and physical inactivity increase the risk of many types of cancer. Effective weight management, healthy diet, and physical activity are critical to reduce cancer risk. This pilot study of a technology-based weight loss program evaluated the program feasibility, weight loss, and improvement of healthy behaviors and quality of life among minority and medically underserved participants with obesity for cancer prevention. Methods: Participants in this pilot study were included from four cohorts: 1) Mano a Mano Mexican American Cohort (MAC; family dyads) 2) Project CHUR

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Kim, Dong Hee, Min Jung Sung, Moon Ju Kim, Jeong Yup Lee, Reener Balingit, and Zul Surani. "Abstract B050: Health and faith in the Korean community: Increasing breast and colorectal cancer education and screening in Los Angeles." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): B050. http://dx.doi.org/10.1158/1538-7755.disp24-b050.

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Abstract Background: Koreatown in Los Angeles is home to over 115 churches within 3 miles. Korean churches are sanctuaries that provide support and nurture social connections, especially among Korean immigrants with limited English proficiency, who face challenges in accessing cancer care, including language barriers, lack of health insurance, and fears associated with cancer screening procedures and treatments. Koreans experience higher incidence and prevalence rates of breast and colorectal cancers compared to non-Hispanic White and other Asian subgroups, respectively. To address this, a Hea

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Jackson, Toni M., John Onyekaba, Kingsley K. Njoku, et al. "Abstract A133: The Church Study: Bridging the gap in colorectal cancer screening of Black patients." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): A133. http://dx.doi.org/10.1158/1538-7755.disp24-a133.

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Abstract Introduction: Colorectal cancer (CRC) is the second leading cause of cancer death in the US, disproportionately affecting Black Americans with a 25% higher risk and 40% greater mortality than non-Hispanic White Americans. Data on CRC screening preferences among Black patients is limited. We conducted a survey to evaluate CRC screening preferences and barriers to screening after a culturally tailored educational talk among Black churchgoers. Aim: The aim of this study is to assess the preferences and barriers to CRC screening among Black Americans, utilizing culturally tailored educati

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Thompson, Jamie, Jennifer Rivelli, Priyanka Gautom, et al. "Abstract A050: Faith-based messaging and materials for colorectal cancer screening in the African Methodist Episcopal church." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (2023): A050. http://dx.doi.org/10.1158/1538-7755.disp23-a050.

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Abstract Introduction: Religion plays a significant role in Black and African American communities, yet little is known about ways to incorporate faith into colorectal cancer (CRC) screening messages and how to distribute such messages to the congregation and community. Brief description of pertinent experimental procedures: We collaborated with members of the African Methodist Episcopal (AME) church in Atlanta, Georgia to create culturally appropriate and locally relevant faith-based CRC screening messages and materials. We used a modified boot camp translation (BCT) approach to obtain input

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Morales-Rivera, Carlos S., Emilia R. Driscoll, and Esther A. Peterson-Peguero. "Abstract 6200: MANGO: pipeline for identifying genomic translocations with key biological significance in inflammatory breast cancer." Cancer Research 82, no. 12_Supplement (2022): 6200. http://dx.doi.org/10.1158/1538-7445.am2022-6200.

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Abstract Genomic instability in cancer is essential for aberrant gene expression and translocation events that potentiate oncogenesis. Thus gene fusions, nonsense mutations and gene deregulation are key contributors to oncogenic phenotypes. Certain genomic translocations have been linked to cancer subtypes, such BCR—ABL1 for chronic myeloid leukemia (CML) serving as potential onco-biomarkers. Inflammatory breast cancer (IBC) is the rarest and most lethal subtype of breast cancer with a 5-year survival rate below 50%. Ethnic disparities for breast cancer exist; negative estrogen (ER) and proges

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Wang, Victoria, Hadley Reid, Andrea Pelletier, et al. "Abstract A132: Time to treatment by neighborhood among endometrial intraepithelial neoplasia and endometrial cancer patients." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (2023): A132. http://dx.doi.org/10.1158/1538-7755.disp23-a132.

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Abstract Objective: To examine interval wait time for surgery in EIN and Endometrial Cancer patients at a single institution and identify potential disparities in access to care Methods: At this single institution, five priority neighborhoods where medically underserved populations reside have been designated from a Community Health Needs Assessment. We performed a retrospective chart review of patients with EIN or endometrial cancer at a single institution between 2016-2019. Patients from one of five priority neighborhoods were compared with patients from other zip codes within the same state

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You, Eunae, Patrick Danaher, Chenyue Lu, et al. "Abstract A039: Repeat RNA mediated disruption of cellular plasticity in pancreatic cancer." Cancer Research 84, no. 17_Supplement_2 (2024): A039. http://dx.doi.org/10.1158/1538-7445.pancreatic24-a039.

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Abstract Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimics viral-like responses with implications for tumor cell state and the surrounding microenvironment. To better understand the relationship of repeat RNAs in human PDAC, we employed the NanoString CosMx™ spatial molecular imaging (SMI) platform, which utilizes a 1,000-plex RNA panel with custom repeat RNA probes targeting long interspersed nuclear element 1 (LINE-1) retrotransposon ORF1 and ORF2, HSATII satellite (SAT) repeat, and two human endogenous retroviruses (HERV-K and HERV-H) in 46 primary tumors.

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Abbott, Keene L., Sonu Subudhi, Raphael Ferreira, et al. "Abstract A007: Assessment of metabolic vulnerabilities of breast cancer brain metastasis." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): A007. http://dx.doi.org/10.1158/1538-8514.synthleth24-a007.

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Abstract The metastasis of cancer to the brain is a major contributor to patient morbidity and mortality. Prior work suggests that there is therapeutic potential in targeting metabolic processes within brain metastatic cancer, however how best to identify novel targets and select patient populations remains unclear. In this study, we determine what nutrients are available to breast cancer cells in the brain and how those nutrients are used. We also engineer breast cancer cells that are auxotrophic for specific nutrients and assess how this impacts tumor growth in the brain using various approa

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Greiner, Daniel, Qian Xue, Trinity Waddell, and Minna Roh-Johnson. "Abstract 5245: Anti-CSPG4 CAR-Macrophages synergize with anti-CD47 in melanoma cytotoxicity." Cancer Research 84, no. 6_Supplement (2024): 5245. http://dx.doi.org/10.1158/1538-7445.am2024-5245.

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Abstract While CAR T-cells have been a success in treating liquid tumors, these successes have not been replicated in solid tumors. There are several reasons for these challenges, including physical matrix barriers and increased tumor antigen heterogeneity in solid tumors. Macrophages are frequently found in melanoma tumors, even in those that have low T-cell infiltrate, suggesting macrophages are well equipped to penetrate the physical barriers surrounding solid tumors. Macrophages are also antigen-presenting cells, thus, if macrophages phagocytose the tumor, they will likely present addition

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Talip, Marian F., Trinity Casimir, Jillian H. Hurst, et al. "Abstract P023: The impact of limited English proficiency and healthcare access on HPV vaccine uptake in the United States." Cancer Prevention Research 16, no. 1_Supplement (2023): P023. http://dx.doi.org/10.1158/1940-6215.precprev22-p023.

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Abstract Background: Limited English proficiency (LEP) impacts patient-provider communication and access to healthcare, both of which are also associated with human papillomavirus (HPV) vaccine uptake. We examined the association between LEP and HPV vaccine uptake among parents/guardians of adolescents and young adults eligible for the HPV vaccination in the United States. Methods: Using a cross-sectional study design, we analyzed nationally representative data from the National Health and Nutrition Examination Survey between 2017 and 2020 (n = 3,993). Outcome of interest was HPV vaccine uptak

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Schubel, Laura C., Mandi L. Pratt-Chapman, Teletia Taylor, et al. "Abstract B031: Preferences for social risk factor screening among breast and prostate cancer survivors in the Washington DC region: A qualitative study." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): B031. http://dx.doi.org/10.1158/1538-7755.disp22-b031.

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Abstract Despite improvements in cancer outcomes over time, significant disparities remain between Black and White cancer survivors. Medical care is estimated to account for 10-20% of health outcomes, while other modifiable factors explain as much as 80-90% of outcomes. These disparities may thus be driven by multiple factors including social determinants of health, differences in treatment or follow up, or attitudes and behaviors of care teams. As part of a larger project, we conducted a qualitative study to understand cancer survivor preferences for and experiences with social needs screenin

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Wang, Yiyun, Xiangjun He, Linqin Wang, et al. "Abstract 3155: "Super NK cells" - natural killer cells derived from engineered hiPSC with enhanced NK receptor expression demonstrate better anti-tumor effects for solid tumors." Cancer Research 82, no. 12_Supplement (2022): 3155. http://dx.doi.org/10.1158/1538-7445.am2022-3155.

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Abstract CAR-T cells expressing chimeric antigen receptors (CAR) have shown clinical success for treating hematologic malignancies, but their efficacy in solid tumors has been limited, largely due to tumor heterogeneity and immunosuppressive tumor microenvironment (TME). Natural Killer (NK) cells derived from human induced pluripotent stem cells (hiPSC) hold great potential to become the next-generation cell therapy products because of their established safety profile and their unique biological activities, especially their potential effectiveness for targeting solid tumor. In contrast to T ce

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Abad, Leslie, Maxine McClain, Edward Bonnevie, et al. "Abstract 986: A BioPharma best practices framework to enable successful morphology guided spatial biology studies using NanoString GeoMx® Digital Spatial Profiler." Cancer Research 83, no. 7_Supplement (2023): 986. http://dx.doi.org/10.1158/1538-7445.am2023-986.

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Abstract The interest and utility of high-plex spatial profiling of RNA and protein biomarkers has increased over the last few years. The implementation of high-plex analyte spatial platforms, such as GeoMx® Digital Spatial Profiler (DSP), is increasing within discovery and development approaches for biomarkers associated with clinical outcome. The surge in spatial platforms parallels the increase of digital pathology in translational and clinical research studies. The integration of these two workflows has the potential to benefit diagnostic and therapeutic development. This study aims to fac

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Uchio, Ed, Donald Lamm, Neil Shore, et al. "Abstract CT233: A phase 3, single-arm study of CG0070 in subjects with non-muscle invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG)." Cancer Research 82, no. 12_Supplement (2022): CT233. http://dx.doi.org/10.1158/1538-7445.am2022-ct233.

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Abstract IntroductionCG0070 is a serotype 5 adenovirus engineered to express GM-CSF and replicate in cells with mutated or deficient RB, with response rates (RR) of approximately 45% observed in patients with recurrent NMIBC after BCG (J Urol. 2012;188:2391-7; Urol Oncol. 2018;36(10):440-7). This single arm phase 3 study (NCT04452591) was launched to confirm the clinical activity of CG0070 in patients with BCG Unresponsive NMIBC.Methods110 patients with BCG-unresponsive CIS with or without concurrent Ta or T1 disease will be treated with intravesical (IVe) CG0070 at a dose of 1x1012 vp. CG0070

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Church, Sarah E., Cheryl London, Christine M. Toedebusch, Ben Sutton, Sarah Weigel, and Erin Piazza. "Abstract 46: High-plex spatial transcriptomic characterization of canine tumor tissue." Cancer Research 83, no. 7_Supplement (2023): 46. http://dx.doi.org/10.1158/1538-7445.am2023-46.

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Abstract Background: Combination therapy to treat hematological and solid malignancies including chemotherapy, radiation, targeted and immunotherapy all hold huge potential for eliciting clinical responses. Informative pre-clinical testing of these approaches can be greatly facilitated using immune competent animals with spontaneous tumors. Pet dogs are immunologically outbred, immune competent and develop spontaneous tumors such as non Hodgkin’s lymphoma, glioblastoma, osteosarcoma, urothelial carcinoma and melanoma that share remarkable clinical, biological and genetic features with their hu

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Wright, J. R. C. "A Requiem for Hitler and other new perspectives on the German church struggle. By Klaus Scholder. (Trans, selections by John Bowden from Die Kirchen zwischen Republik und Gewaltherrschaft, Berlin: Siedler, 1988.) Pp. xviii + 203. London: SCM Press/Philadelphia: Trinity Press, 1989. £8.50. 0 334 02295 9." Journal of Ecclesiastical History 41, no. 4 (1990): 696–98. http://dx.doi.org/10.1017/s0022046900075874.

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Casimir, Trinity, Marian F. Talip, Dina K. Abouelella, et al. "Abstract P018: Differences in guideline-recommended age of human papillomavirus (HPV) vaccine initiation and completion in the United States." Cancer Prevention Research 16, no. 1_Supplement (2023): P018. http://dx.doi.org/10.1158/1940-6215.precprev22-p018.

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Abstract Background: While there has been increase in the uptake of the human papillomavirus (HPV) vaccine, current vaccine rate fell short of the Healthy People 2020 target. The Centers for Disease Control and Prevention (CDC) recommends that the vaccine be routinely administered to children between 11 and 12 years and could begin as early as 9 years of age. However, it is unclear to what extent the CDC’s guideline-recommended age of HPV vaccine uptake is followed. Objective: To test the hypothesis that HPV vaccine uptake is more likely at an older age in the United States rather than the CDC

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Hu, Jiabiao, Xiangjun He, Jing Xu, et al. "Abstract 6070: Functional natural killer cells derived from engineered hiPSC with hypoimmunity gene combo demonstrate hypoimmunity features in evading host attacks." Cancer Research 82, no. 12_Supplement (2022): 6070. http://dx.doi.org/10.1158/1538-7445.am2022-6070.

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Abstract Engineered human induced pluripotent stem cells (hiPSC)-derived allogeneic Natural Killer (NK) cells are emerging as promising safe and effective off-the-shelf cell therapy drugs. Repeated dosing of NK cells can partly compensate the relatively shorter persistence of NK cells compared with chimeric antigen receptor T cells (CAR-T); However, with each repeat, the persistence and efficacy are increasingly challenged by activation of host innate and adaptive immunity. Thus, reducing immunogenicity of allogeneic NK cells holds promise for better efficacy. In this study, we report a combin

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Bischof, Julia, Jonathan Woodsmith, and David Church. "Abstract 409: Deciphering chromosomal instability in consensus molecular subtypes (CMS) in CRC: Insights from an integrative multi-omics approach." Cancer Research 84, no. 6_Supplement (2024): 409. http://dx.doi.org/10.1158/1538-7445.am2024-409.

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Abstract CRC is a heterogeneous disease with different molecular subtypes, which can have a profound impact on treatment response and patient outcomes. CMS classification based on gene expression profiles has been shown to differentiate patients into clinically relevant sub-groups. However, deep multi-omics characterization of the CMS classes based on high quality patient data is lacking. Through the integration of multi-omics data, we aim to enhance our understanding of CRC’s molecular heterogeneity and thereby facilitate the development of personalized therapeutic strategies. We performed a

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Church, Isabella, Charli Gruen, Antonella Sassano, et al. "Abstract 141: Interrogating subclonal mechanisms of immune evasion and immunotherapy resistance in melanoma." Cancer Research 83, no. 7_Supplement (2023): 141. http://dx.doi.org/10.1158/1538-7445.am2023-141.

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Abstract Immune checkpoint blockade (ICB) therapies are the current first-line melanoma treatments within the clinic; however, their specific mechanisms for combatting tumor progression remain unclear and determinants for efficacious and durable responses within patients remain unknown. Intratumor heterogeneity (ITH) provides cancers with significant adaptability, leading to metastatic progression and resistance to treatment, but its complexity often complicates its study. To understand how ITH contributes to ICB response, we derived 24 clonal sublines from single cells of an ICB-sensitive and

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Hogan, Meghan, Andrea Hernández Rojas, Araba Sagoe-Wagner, et al. "Abstract 1230: High throughput quantitative molecular characterization of cytotoxic antibody-drug conjugates in spheroid models for improved functional characterization, screening and candidate selection." Cancer Research 85, no. 8_Supplement_1 (2025): 1230. https://doi.org/10.1158/1538-7445.am2025-1230.

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Abstract Background: Antibody-drug conjugates (ADCs) are a class of cancer therapeutics comprised of a linker-payload conjugated to a monoclonal antibody targeting a tumor-associated antigen (TAA), to enable the delivery of the cytotoxic payload to cancer cells. Presently, there is a need for improved in vitro models that better recapitulate in vivo tumor tissue complexity to aid in the screening and evaluation of novel ADCs during preclinical development. Specifically, we have developed in vitro 3D models from cancer cell lines yielding spheroids in a rapid, robust and uniform manner. Using t

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