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Relevant bibliographies by topics / Trisaccharide Lewis a

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Academic literature on the topic 'Trisaccharide Lewis a'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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Journal articles on the topic "Trisaccharide Lewis a"

1

Su, Zheng, Beatrice Wagner, Emilio J. Cocinero, Beat Ernst, and John P. Simons. "The intrinsic conformation of a Lewis antigen: The Lewis×trisaccharide." Chemical Physics Letters 477, no. 4-6 (2009): 365–68. http://dx.doi.org/10.1016/j.cplett.2009.07.006.

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2

Khebichat, N., K. Nekkaz, and S. Ghalem. "Conformational Search on the Lewis X Structure by Molecular Dynamic: Study of Tri- and Pentasaccharide." International Journal of Carbohydrate Chemistry 2012 (February 13, 2012): 1–7. http://dx.doi.org/10.1155/2012/725271.

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Carbohydrates play vital roles in many biological processes, such as recognition, adhesion, and signalling between cells. The Lewis X determinant is a trisaccharide fragment implicated as a specific differentiation antigen, tumor antigen, and key component of the ligand for the endothelial leukocyte adhesion molecule, so it is necessary or essential to determine and to know their conformational and structural properties. In this work, conformational analysis was performed using molecular dynamics (MD) simulation with the AMBER10 program package in order to study the dynamic behavior of of the

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3

Moore, Christopher J., and France-Isabelle Auzanneau. "Synthesis of 4” manipulated Lewis X trisaccharide analogues." Beilstein Journal of Organic Chemistry 8 (July 23, 2012): 1134–43. http://dx.doi.org/10.3762/bjoc.8.126.

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Three analogues of the Lex trisaccharide antigen (β-D-Galp(1→4)[α-L-Fucp(1→3)]-D-GlcNAcp) in which the galactosyl residue is modified at O-4 as a methyloxy, deoxychloro or deoxyfluoro, were synthesized. We first report the preparation of the modified 4-OMe, 4-Cl and 4-F trichloroacetimidate galactosyl donors and then report their use in the glycosylation of an N-acetylglucosamine glycosyl acceptor. Thus, we observed that the reactivity of these donors towards the BF3·OEt2-promoted glycosylation at O-4 of the N-acetylglucosamine glycosyl acceptors followed the ranking 4-F > 4-OAc ≈ 4-OMe &gt

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4

Jegatheeswaran, Sinthuja, Ari Asnani, Adam Forman, et al. "Recognition of Dimeric Lewis X by Anti-Dimeric Lex Antibody SH2." Vaccines 8, no. 3 (2020): 538. http://dx.doi.org/10.3390/vaccines8030538.

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The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics. Using the native DimLex antigen as a vaccine would elicit an autoimmune response against the Lex antigen found on normal, healthy cells. Thus, we aim to study the immunogenic potential of DimLex and search internal epitopes displayed by DimLex that remain to be recognized by anti-DimLex monoclonal antibodies (mAbs) but no longer possess epitopes recognized by anti-Lex mAbs. In this context, we attempted to map the epitope recognize

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5

Auzanneau, France-Isabelle, Elizabeth Sourial, Jonathan M. Schmidt, and Miklos Feher. "Stochastic conformational search on the Lewis X (Lex) trisaccharide and three Lex analogues." Canadian Journal of Chemistry 80, no. 8 (2002): 1088–95. http://dx.doi.org/10.1139/v02-163.

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Biased stochastic conformational searches using the MMFF94 force field and the Born continuum solvation model were applied to the molecular modeling of the Lewis X (Lex) trisaccharide (β-D-Gal-(1,4)-[α-L-Fuc-(1,3)]-β-D-GlcNAc-OH) and three Lex analogues, in which each of the three sugar units was replaced by another sugar residue, i.e., N-acetyl-glucosamine by glucose, galactose by glucose, and fucose by rhamnose. The stochastic search accurately identified a lowest energy conformation of the Lex determinant that corresponds to the reported conformations of Lex deduced experimentally in the so

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6

Soliman, Sameh E., Rafik W. Bassily, Ramadan I. El-Sokkary, Joseph Banoub, and Mina A. Nashed. "Regioselective synthesis of a glycomimetic trisaccharide of Sialyl Lewis (sLex)." Carbohydrate Research 344, no. 3 (2009): 395–99. http://dx.doi.org/10.1016/j.carres.2008.11.019.

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7

Ellervik, Ulf, Hans Grundberg, and Göran Magnusson. "Synthesis of Lactam and Acetamido Analogues of Sialyl Lewis x Tetrasaccharide and Lewis x Trisaccharide." Journal of Organic Chemistry 63, no. 25 (1998): 9323–38. http://dx.doi.org/10.1021/jo981204p.

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8

Soliman, Caroline, Andrew J. Guy, Jia Xin Chua, et al. "Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody." Biochemical Journal 477, no. 17 (2020): 3219–35. http://dx.doi.org/10.1042/bcj20200454.

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Immunotherapy has been successful in treating many tumour types. The development of additional tumour-antigen binding monoclonal antibodies (mAbs) will help expand the range of immunotherapeutic targets. Lewis histo-blood group and related glycans are overexpressed on many carcinomas, including those of the colon, lung, breast, prostate and ovary, and can therefore be selectively targeted by mAbs. Here we examine the molecular and structural basis for recognition of extended Lea and Lex containing glycans by a chimeric mAb. Both the murine (FG88.2) IgG3 and a chimeric (ch88.2) IgG1 mAb variant

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9

Sanders, William J., Tamiko R. Katsumoto, Carolyn R. Bertozzi, Steven D. Rosen, and Laura L. Kiessling. "L-Selectin−Carbohydrate Interactions: Relevant Modifications of the Lewis x Trisaccharide†." Biochemistry 35, no. 47 (1996): 14862–67. http://dx.doi.org/10.1021/bi9613640.

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10

Csonka, Gábor I., Carlos P. Sosa, and Imre G. Csizmadia. "Ab Initio Study of Lowest-Energy Conformers of Lewis X (Lex) Trisaccharide." Journal of Physical Chemistry A 104, no. 15 (2000): 3381–90. http://dx.doi.org/10.1021/jp9935034.

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Dissertations / Theses on the topic "Trisaccharide Lewis a"

1

Prickett, Mark Peter. "Probing the structure of Lewis X trisaccharide." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319046.

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2

Daniellou, Richard. "Synthèse chimio-enzymatique d'oligosaccharides sur support soluble dendrimérique." Paris 11, 2003. http://www.theses.fr/2003PA112180.

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Alors que l'importance biologique des protéines et des acides nucléiques est connue depuis longtemps, c'est seulement depuis quelques années que l'on a pris conscience de l'importance des sucres dans de nombreux phénomènes biologiques. Cependant, le problème majeur qui empêche le développement rapide de la glycobiologie se situe dans le manque de sucres complexes parfaitement purs et structurellement définis. Pour circonvenir à ce problème, nous avons décidé de combiner les avantages de la synthèse supportée avec ceux de l'utilisation d'enzymes. Lors de telles synthèses chimio-enzymatiques, de

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