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Dissertations / Theses on the topic 'Trisubstituted'

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Published: 5 June 2025
Last updated: 1 August 2025

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1

Dixon, Nicholas John. "Stereoselective synthesis of trisubstituted alkenes." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255821.

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2

Cariou, Claire. "Diastereoselective synthesis of 2,4,5-trisubstituted piperidines." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434701.

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3

Bergman, Zara Dominique. "2,3,4-trisubstituted piperidines : a stereocontolled approach." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5794/.

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This thesis details a methodology utilising various synthetic pathways towards cyclisation precursors suitable for use in Prins and carbonyl-ene cyclisations to effect 2,3,4-trisubstituted piperidines. Once the precursors were synthesised, we were interested in the stereochemical outcomes of the cyclisations, in particular identity and rational of the kinetic and thermodynamic products and their variation due to differing substituents on C2. Previous work in the Snaith group has addressed various other substitution patterns and 2,3,4-trisubstituted piperidines are central components of a vast
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4

Feuillet, Frederic. "Stereoselective synthesis of (E)-trisubstituted acid derivatives." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397111.

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5

Troutman, Malisa V. (Malisa Vaughn) 1970. "Asymmetric hydrogenation of unfunctionalized trisubstituted and tetrasubstituted olefins." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/9636.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.<br>Includes bibliographical references (leaves 97-98).<br>A highly reactive chiral catalyst for the asymmetric hydrogenation of aryl trisubstituted olefins was generated by combining the complex (EBTHI)MMe2 (EBTHI = ethylenebistetrahydroindenyl, M = Ti, Zr) with [PhMe2NH]+[(BC6F5)4]- under a hydrogen atmosphere. A number of unfunctionalized trisubstituted olefins could be hydrogenated rapidly at room temperature under 80 psig H2 with a wide range of ee's (7 97% ). Reduction of some substrates under a deuterium a
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6

Gunn, Andrew Fraser. "Trisubstituted η³-allyl molybdenum complexes : synthetic studies towards ebelactone." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396740.

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7

Repasky, Paul J. "Novel Trisubstituted Arylidene Oxindoles with Potent Anti-Apoptotic Properties." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1310326721.

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8

Pimm, Austen David. "The application of #alpha#-metallated heterosubstituted alkenes to trisubstituted alkene synthesis." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332548.

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9

Sadler, Matthew James. "Diastereoselective synthesis of 2,4,5 trisubstituted piperidines : application in natural product synthesis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2901/.

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This thesis describes the diastereoselective synthesis of 2,4,5-trisubstituted piperidines using carbonyl-ene and Prins cyclisations and their application in natural product synthesis. Following on from previous work in the group, we investigated how a preinstalled substituent in the 2-position can help to control the sense of induction at the two newly forming stereocentres. We utilised the Prins reaction in the formal synthesis of pseudodistomin F, a marine alkaloid that posses a 2,4,5-tribsubstituted piperidine core. An initial first generation synthesis focused on the construction of a cyc
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10

Qin, Can. "Synthesis of Trisubstituted α,β-Unsaturated Esters through Catalytic Stereoretentive Cross-Metathesis:". Thesis, Boston College, 2021. http://hdl.handle.net/2345/bc-ir:109197.

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Thesis advisor: Amir H. Hoveyda<br>We have devised a broadly applicable catalytic cross-metathesis method for stereoretentive synthesis of Z- and E-trisubstituted α,β-unsaturated esters. Several new Mo-bisaryloxide complexes were prepared, and they showed superior efficiency in synthesizing the Z-trisubstituted enoates (vs. corresponding mono-aryloxide pyrrolide complexes). Synthetic utility of the method was demonstrated through several concise syntheses of bioactive triterpenoids and value-added derivatives of prenyl-containing compounds such as citronellal, citronellol, and geraniol, all of
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11

Chandan, Nandkishor Shankarrao. "Novel methodology for synthesis of trisubstituted pyrrolidines : application towards the synthesis of kaitocephalin." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543061.

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12

Davidson, James Prentice. "Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide mimics /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008309.

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13

Gao, Sirong. "Applications of beta-enaminonitriles : synthesis of 1,5,6-trisubstituted cytosines; synthetic approaches to (-)-swainsonine." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318319.

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14

McKeveney, Declan, and n/a. "The Solid-Phase Combinatorial Synthesis of 2,6,9- Trisubstituted Purines as Potential Adenosine A3 Receptor Antagonists." Griffith University. School of Science, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050830.120105.

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Purines as a class of compounds have been implicated in many biological systems, including as adenosine receptor antagonists. A method of synthesising 2,6,9-trisubstituted purines would be useful to produce small libraries of compounds for probing adenosine receptor selectivity. A library of trisubstituted purines has been achieved using a solid-phase methodology. The electronic properties of the substrate were found to result in difficulties with the loading of substrate onto the resin. Theoretical calculations provided the basis for mono-substitution in order to activate the substrate. This
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15

McKeveney, Declan. "The Solid-Phase Combinatorial Synthesis of 2,6,9- Trisubstituted Purines as Potential Adenosine A3 Receptor Antagonists." Thesis, Griffith University, 2005. http://hdl.handle.net/10072/367926.

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Purines as a class of compounds have been implicated in many biological systems, including as adenosine receptor antagonists. A method of synthesising 2,6,9-trisubstituted purines would be useful to produce small libraries of compounds for probing adenosine receptor selectivity. A library of trisubstituted purines has been achieved using a solid-phase methodology. The electronic properties of the substrate were found to result in difficulties with the loading of substrate onto the resin. Theoretical calculations provided the basis for mono-substitution in order to activate the substrate. This
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16

Chapman, Gala M. "Spectroscopic Studies of Carbocyanine and 2,4,6- Trisubstituted Pyridine Dyes for Bioanalytical and pH Indicating Applications." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_theses/47.

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In part A, the effect of varying short-chain alkyl substitution on the spectroscopic properties of cyanine dyes was examined. Molar absorptivities and quantum yields were determined for groups of pentamethine and heptamethine dyes for which the substitution of the indole nitrogen was varied. For both sets of dyes, increasing alkyl chain length did not significantly change quantum yield or molar absorptivity. These results may be useful in designing new cyanine dyes. In part B, the effect of structure on the suitability of 2,4,6-trisubstituted pyridines as color pH indicators was studied by det
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17

Lecea, Romera Mercedes. "Stereoselective synthesis of the natural metabolite of tocopherol, (S)-y-CEHC, and monofluorinated trisubstituted olefins." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-01064056.

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This PhD work has been focused in two different subjects : - The stereoselective synthesis of 2,2-disubstituted chroman moiety assisted by sulfoxides as only source of chirality has been realized with good yields and good diastereoselectivities. The total synthesis of the natural metabolite of tocopherol, (S)-γ-CEHC, has been realized in ten steps and in 18.4% of overall yield using as key step the formation of ally sulfinyl chroman by reaction with allyl trimethyl silane in the presence of a Lewis acid. - The stereoselective synthesis of monofluorinated trisusbtituted olefins has been realize
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18

Biggs, Robyn A. "5-and 6-Membered Hydrazides as Potential Catalysts for Diels-Alder Cycloadditions." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30723.

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Part A: Synthesis of 5- and 6-Membered Camphor-Based Hydrazides as Organocatalysts for Cycloaddition Reactions The favorable environmental and reactivity qualities of organocatalysts are contributing to the popularization of this method for the acceleration of enantioselective reactions. Research in our group has been focused on the synthesis of camphor-derived hydrazide based organocatalysts for enantioselective cycloaddition processes. Recent results suggest that the presence of an exocyclic electron withdrawing group on the hydrazide moiety, as well as the incorporation of the hydrazide m
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19

Rajagopal, Thivisa. "Synthesis of Single Isomer Trisubstituted Olefins from beta-chloro-alpha-iodo-alpha, beta-Unsaturated Esters and Alkynyl Esters." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28552.

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A convenient method to synthesize regiospecific and stereoselective trisubstituted olefins bearing three substitutents with various functionalities is disclosed. A unique olefin template such as (E)-beta-chloro-alpha-iodo-alpha,beta-unsaturated esters cross-couple with 9-alkyl-9-BBN to produce single isomer trisubstituted olefins using palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. This methodology can be further expanded to introduce various alkyl groups at the beta-position. The mechanism is somewhat unusual as it involves two catalytic cycles with an allenoate intermediate to e
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20

De, Carvalho Annelise. "Contribution to the in vitro evaluation of trisubstituted harmine derivatives effects on the protein synthesis in cancer cell lines." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/262289.

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SUMMARY: Cancers represent one of the main causes of death worldwide. Together with surgery and radiotherapy, chemotherapy constitutes a main therapeutic tool in cancer treatment. However, combat remains challenging because of the intrinsic and/ or acquired resistance mechanisms displayed by cancers to these agents. In order to maintain their continuous growth, multiplication and dissemination, cancer cells display a number of biological hallmarks. Growing evidence of the remarkable association of the protein synthesis process with the onset and progression of cancer has led to extensive revis
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21

Pianosi, Anthony. "Synthesis of Single Isomer Trisubstituted and Tetrasubstituted Olefins from E-β-Chloro-α-Iodo-α,β-Unsaturated Esters and Bergman Cycloaromatizations With and Without a Radical Trapping Agent". Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20456.

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Optimized methods for the regioselective and stereospecific synthesis of both trisubstituted and tetrasubstituted olefins as single isomers from E-β-chloro-α-iodo-α,β-unsaturated esters have been developed from previous work done in the Ogilvie lab. These optimized methods have led to the synthesis of trans isomeric enediynes that can be photoisomerized to their respective cis isomers and subsequently undergo microwave-assisted Bergman cycloaromatizations. Furthermore, both cis and trans isomeric enediynes that have propargyl ether substituents have been found to be able to undergo photoacti
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22

Wittmann, Stephane. "Synthesis of trisubstituted olefins by RCM using an O-Si-C tether : application to the total synthesis of dolabelide C." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7068/.

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Dolabelide C is a macrolide, part of the dolablide family, isolated in 1997 from the Japanese sea hare, Dolabella auricularia. Dolabelide C contains a polyhydroxylated macrocycle structure with eleven stereogenic centers and two trisubstituted olefins. It exhibits cytotoxicity against cervical cancer HeLa-S3 cells. Dolabelide C and the other members of the dolabelide family have been the object of several studies in several groups. The approach envisaged in the Prunet group towards the synthesis of dolabelide C consists in disconnecting the molecule into two fragments of similar lengths, the C
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23

Elacqua, Elizabeth. "Supramolecular chemistry of molecular concepts: tautomers, chirality, protecting groups, trisubstituted olefins, cyclophanes, and their impact on the organic solid state." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3447.

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The research presented in this thesis is founded upon the ability to mimic Nature by using highly directional forces to influence self-assembly, while achieving the formation of desired supramolecular structures. The successful engineering of such solids relies upon a full comprehension of supramolecular synthons, so as to apply them to design complex architectures. We have studied synthon formation in multifunctional pharmaceutical solids. Through the formation of salts and co-crystals, we uncovered a role of tautomers in the salt – co-crystal continuum. From a solid-state perspective, one ca
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24

Chen, Grace Shiahuy. "An experimental and theoretical study of dinitrogen related chemistry : electronic structures of aliphatic diazonium ions, symmetrical and asymmetrical azines, and group VIA trisubstituted carbenium ions /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737904.

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25

Abdel-Latif, Mohammad Abdel-Halim Abdel-Naby [Verfasser], and Rolf W. [Akademischer Betreuer] Hartmann. "Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of PKCzeta / Mohammad Abdel-Halim Abdel-Naby Abdel-Latif. Betreuer: Rolf W. Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1078017085/34.

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26

Igdir, A. Cigdem. "Reinvestigation Of The Synthetic And Mechanistic Aspects Of Manganese(iii) Acetate Mediated Reactions Synthesis Of 1,2,4-trisubstituted Pyrroles Via Amination / Annulation Reactions Of Chloroenones With Chiral Amine Compounds." Phd thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607643/index.pdf.

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The first part of the thesis presents the reinvestigation of the synthetic and mechanistic aspects of manganese (III) acetate mediated reactions. The main concern about this subject was to perform a &cent<br>- acetoxylation reactions of enones and saturated systems in shorter reactions times and higher yields than the ones known in literature reproducibly. Although successful a &cent<br>-acetoxylation of a great variety of substrates have been reported so far, there are some problems associated with the use of Mn(OAc)3. Considering that there are not many simple methods for the direct acetoxyl
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27

Chaillou, Bérénice. "Conception, synthèse et évaluation biologique d’inhibiteurs de PfA-M17, potentielle cible antipaludéenne." Thesis, Mulhouse, 2015. http://www.theses.fr/2015MULH8176/document.

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Le paludisme, maladie infectieuse due à des parasites du genre Plasmodium, reste mortel et préoccupant dans les régions intertropicales d’Afrique, d’Asie et d’Amérique. Les phénomènes de résistance des parasites aux différentes générations de traitements représentent un problème majeur, auxquels s’ajoutent le coût des traitements et donc l’accès aux soins pour les populations les plus défavorisées. Il est ainsi urgent de trouver de nouvelles cibles et de développer de nouveaux agents antipaludiques agissant via des mécanismes originaux. La cible étudiée lors de ces travaux de thèse est la leuc
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28

N'gompaza, Diarra Joannah. "Synthèse et évaluation biologique d’imidazo[1,2-b]pyridazines et de purines inhibitrices de protéines kinases." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P613/document.

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Le travail s’est articulé autour de la synthèse et de l’évaluation biologique de nouveaux inhibiteurs de protéines kinases dont essentiellement de kinases dépendantes de cyclines (CDKs). La dérégulation de ces kinases est mise en cause dans l’apparition de nombreuses pathologies prolifératives telles que le cancer ou non prolifératives telles que les maladies neurodégénératives. Deux types d’inhibiteurs ont été préparés. La première famille de composés étudiée est la famille des purines, sur laquelle a été introduite des substructures de type aminodiols en position C-2. Ces aminodiols ont été
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29

Bush, Alexander Graham. "Part A: Design of new camphor-based hydrazide organocatalysts and their applications to enantioselective Friedel-Crafts alkylations Part B: The development of the palladium catalyzed addition of organoborates to alkynyl esters: Synthesis of trisubstituted olefins as single isomers." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28272.

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Part A. Asymmetric synthesis is a growing field in synthetic and medicinal chemistry. Investigations into the use of organocatalysts to engender chirality into organic molecules is of particular interest. Herein we present the study of the efficiency of camphor-based hydrazide organocatalysts in the asymmetric Friedel-Crafts alkylations of N-methylindole with alpha,beta-unsaturated aldehydes. In addition, the applicability of newly designed second-generation camphor-based hydrazide catalysts will be examined.* Part B. The synthesis of trisubstituted olefins represents an intriguing target in o
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30

Nguyen, Thach Truc. "Practical and stereoselective synthesis of alkenes through catalytic cross-metathesis." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:108254.

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Thesis advisor: Amir H. Hoveyda<br>Abstract Chapter 1: Development of Efficient and Kinetically E-Selective Cross-Metathesis to Generate Alkenyl Halides We have devised a broadly applicable strategy to achieve kinetically E-selective cross-metathesis to generate a valuable set of E-alkenyl chlorides and fluorides in high efficiency. The synthetic utility was demonstrated through several concise syntheses of E-alkenyl chloride and fluoride precursors to biologically active molecules. The design principles delineated in this study are expected to initiate a wider range of efficient and kinetical
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31

Courchinoux, Roger. "Alliages moléculaires en série trisubstituée du benzène : réflexion sur la syncristallisation organique." Bordeaux 1, 1988. http://www.theses.fr/1988BOR10612.

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Apres une premiere partie consacree a la methodologie, dans laquelle le developpement et l'usage d'une methode originale d'etude des signaux d'analyses enthalpiques differentiels sont en particulier decrits, les resultats de la determination de la structure cristalline (desordonnee) du dibromo-1,3 methilbenzene, ainsi que la determination du diagramme d'equilibre entre ce compose et le tribromo-1,3,5 benzene sont donnes. On introduit ensuite la notion de tenseur de deformation compositionnelle (tenseur de rang 2) dont on demontre sur 6 exemples d'alliages moleculaires, l'interet pour leur cara
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32

Plehiers, Mark. "Synthèse de dérivés piperidiniques b-hydroxyles di-et trisubstitues par application de l'oxydation anodique." Doctoral thesis, Universite Libre de Bruxelles, 1995. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212609.

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33

Ibrahim, Nada. "Conception et synthèses régiospécifiques de purines di- et trisubstituées comme inhibiteurs de la glycogène synthase kinase-3." Paris 11, 2010. http://www.theses.fr/2010PA112006.

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La glycogène synthase (GSK-3) est une enzyme qui participe à une multitude de processus biologiques. Elle est notamment impliquée dans certaines maladies comme l’Alzheimer le le diabète de type 2. Dans ce contexte, la GSK-3 est devenue une cible privilégiée en chimie médicinale pour concevoir et découvrir des inhibiteurs sélectifs pouvant présenter un intérêt thérapeutique pour le traitement de ces maladies. Dans le but de continuer la recherche d’inhibiteurs présentant un meilleur profil de sélectivité, nous nous sommes proposés de synthétiser une « librairie » de nouveaux inhibiteurs de GSK-
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34

Jaouen, Aurélie. "Synthèse d'indolo[2,3-b]quinoxalines trisubstituées, une nouvelle famille de ligands des structures G-quadruplexes des télomères." Paris 5, 2008. http://www.theses.fr/2008PA05P622.

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Les télomères, situés à l'extrémité des chromosomes des cellules eucaryotes, et la télomérase, enzyme inactive dans les cellules saines, sont de nouvelles cibles sélectives pour la chimiothérapie antitumorale. La partie simple brin des télomères se replie en quadruplexe (G4) ; les molécules capables d'induire ou de stabiliser les G4 sont des inhibiteurs de l'enzyme. L'objectif de cette thèse a été la conception, la synthèse et l'évaluation biologique de nouveaux ligands sélectifs des G4. Des travaux du laboratoire laissaient penser que des indolo[2,3-b]quinoxalines trisubstituées par des chaîn
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35

Garcia, Michel-Ange. "Epoxydation énantiosélective d'oléfines trisubstituées catalysée par des complexes salen-MnIII : application aux dérivés du geraniol et du nérol." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22027.

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La synthese enantioselective d'epoxydes a partir d'olefines prochirales constitue actuellement un domaine de recherche particulierement actif. C'est ainsi que ces dernieres annees ont vu plus particulierement se developper l'utilisation de complexes (salen)mn optiquement actifs en tant que catalyseurs de la reaction d'epoxydation. Les resultats enregistres principalement par jacobsen et katsuki rendent compte de bons, voire meme, de tres bons rendements et exces enantiomeriques. Cependant, la grande majorite des resultats fournis par la litterature concerne des olefines le plus souvent disubst
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36

ADONIAS, MIREILLE. "Synthese de 2-azetidinones trisubstituees inhibiteurs potentiels d'elastases. Nouvelles voie d'acces radicalaire a des cycles carbapenames et carbapenemes." Paris 11, 1993. http://www.theses.fr/1993PA112324.

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Cette these decrit la synthese enantioselective de beta-lactames utilisant la reaction de staudinger, avec la d-glucosamine comme auxiliaire chiral. Le chapitre i concerne la synthese de monobactames 1,3,4-trisubstitues dont l'etape cle est une reaction de cycloaddition 2+2 entre un cetene et une imine. Le cetene genere a partir de l'acide methoxy acetique ou de l'acide hexanoique, reagit avec une base de schiff chirale obtenue par condensation entre le 3,4;5,6-di-o-isopropylidene 1-propane dithioacetal d-glucosamine et le cinnamaldehyde, ou le methyl-cinnamaldehyde. Les beta-lactames monocycl
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37

Vandromme, Lucie. "Synthèse de purines trisubstituées en tant qu'inhibiteurs potentiels d'enzymes : application à l'inhibition des protéines kinases dépendantes des cyclines (CDK)." Paris 11, 2005. http://www.theses.fr/2005PA112160.

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Les CDK sont les enzymes régulatrices du cycle cellulaire et leur dérégulation est impliquée dans l'apparition du cancer. Elles représentent de ce fait des cibles de choix dans la thérapie anti-cancéreuse. Au laboratoire, les recherches sont donc focalisées sur la synthèse d'inhibiteurs de CDK à la fois puissants et spécifiques. Des inhibiteurs synthétiques efficaces ont pu être découverts malgré la grande similitude structurale existant entre chaque CDK, et les purines constituent une des familles comportant les inhibiteurs les plus spécifiques. Au sein du laboratoire, la synthèse de purines
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38

Brun, Virginie. "Inhibiteurs de kinases dépendantes des cyclines : développement d'une nouvelle stratégie de synthèse de purines 2, 6, 9-trisubstituées sur support solide." Paris 11, 2002. http://www.theses.fr/2002PA112044.

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Pour mettre en évidence de nouveaux inhibiteurs puissants et spécifiques de certaines CDK, nous avons développé une nouvelle stratégie de synthèse sur support solide afin de construire une banque originale de purines 2,6,9-trisubstituées. La stratégie de synthèse doit permettre l'introduction séquentielle des éléments de diversité dans les trois positions du noyau purine. Notre approche met en jeu une purine substituée en C6 par un groupement soufré et immobilisée sur la résine via cet atome de soufre. La faible réactivité et la stabilité de la liaison C6-S par rapport à la liaison C6-Cl, nous
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Vabre, Roxane. "Fonctionnalisation directe de liaisons C-H et couplages croisés pour la formation de liaisons C-C et C-N : synthèse de purines 6,8,9-trisubstituées." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00923198.

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La grande variété de propriétés biologiques associées au noyau purine en fait une structure privilégiée pour la conception et la synthèse de nouvelles molécules à visée thérapeutique. Cette spécificité est étroitement liée à la grande diversité de substituants pouvant être introduits sur les différentes positions du noyau purine et en particulier sur C2, C6, C8 et N9. Par conséquent, le développement de méthodes de fonctionnalisation rapides de cette famille de composés est d'un grand intérêt synthétique. Nous nous sommes focalisés sur la formation de liaisons C-C et C-N sur les positions 6 et
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40

BLANC, DELPHINE. "Hydrogenation asymetrique catalysee par des complexes chiraux du ruthenium : synthese de ligands chiraux a partir de diols 1,3 optiquement purs. synthese asymetrique de gamma-butyrolactones-alpha, beta, gamma-trisubstituees : (-)-methylenelactocine, acide (-)-phaseolinique et (-)-isoavenaciolide." Paris 6, 1999. http://www.theses.fr/1999PA066062.

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Les complexes chiraux du ruthenium, prepares in situ a partir d'un precurseur commercial codru(2-methylallyl) 2, ont ete utilises pour la synthese de nouveaux ligands chiraux et de composes d'interet biologique. Ces catalyseurs se sont reveles particulierement efficaces pour l'hydrogenation asymetrique de nouveaux substrats fluores et de dicetones 1,3 symetriques. Les beta-hydroxyesters fluores, ainsi que les diols 1,3 anti sont obtenus quantitativement avec de bonnes selectivites, allant jusqu'a 99%. Les alcools optiquement purs obtenus sont des intermediaires clefs pour la synthese de produi
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Nguyen, Thu Huong. "Nouvelles méthodes de synthèse des dihydro -2,4 triazol -1,2,4 ones -3 trisubstituées en positions 2,4 et 5 à partir de semicarbazones disubstituées en positions 2 et 4 d’aldéhydes aromatiques : étude de leurs propriétés antibactérienne, antiparasitaire et herbicide (euglène gracile)." Paris 7, 1985. http://www.theses.fr/1985PA07F133.

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De nouvelles semicarbazones 2,4 disubstituées dont certaines portent un groupe nitro -5 furyle -2 ont été synthétisées. L’emploi de nouveaux oxydants, le bioxyde de plomb et le monochlorure de soufre, ont permis de les cycliser en dérivés dihydro -2,4 triazol -1,2,4 ones –3 correspondantes. Des mécanismes réactionnels ont été proposés. D'autres réactions de ces oxydants sont présentés. Des tests antibactériens ont été effectués sur E. Coli, S. Aureus et C. Albicans. Les propriétés antiparasitaires ont été étudiées sur Entamoeba Histolytica, Trichomonas vaginalis et Trypanosoma Brucei. L’activi
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42

吳靜雯. "2,7,9-trisubstituted fluorene-based light-emitting materials." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/60172455217352167843.

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碩士<br>中國文化大學<br>應用化學研究所<br>90<br>Amorphous fluorene derivatives that contain diarylamines at the 2 and 7 positions and a dangling arylamine at the 9 position of the fluorene moiety have been synthesized via palladium-catalyzed C-N bond formation. The first series of compounds contain diarylamine moieties at the 2, 7 and 9 positions of fluorene. The second series of compounds contain a cyano (CN) group at the 2-position and diarylamine moieties at the 7 and 9 positions of fluorene. Both series of compounds display a reversible or quasi-reversible oxidation process in cyclic voltammetry. The sec
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Chih-Ming, Chou, and 周志明. "Synthesis of 2,3,5-trisubstituted Furan Derivatives from Propargylic Dithioacetals." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/01013212437679536581.

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碩士<br>國立臺灣大學<br>化學研究所<br>91<br>It has recently been reported in our group a new annulation approach to synthesis of 2,3,5-trisubstituted furans from the corresponding propargylic dithioacetals and aldehydes. Encouraged by this study, we introduced an ester group into the terminal alkyne of propargylic dithioacetal. After annulation, we successfully synthesized a variety of 3-ester-group-substituted furan derivatives. Reaction of progargylic dithioacetals with dialdehydes or trialdehyde afforded a series of bis-furans and C3 symmetry star-shape furan derivatives, respectively. Photop
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Chen, Ming-Jung, and 陳明榮. "Total Synthesis of Natural Trisubstituted Lactones via Tungsten Alkynyl Complexes." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/59608762747124635647.

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博士<br>國立清華大學<br>化學系<br>88<br>Several natural products are found to have α-methylene γ-butyrolactone skeleton. The pharmacological importance of these compounds has always been the driving force for their total synthesis. In the last several years we have also turned our attention towards the toolbox for the facile and stereocontrolled construction of functionalized butyrolactone skeleton. Such as Dr. Kesavaram Narkunan synthesize avenociolide and isoavenociolide; Dr. Chandrasekharam synthesize (-)-methylenolactocin; Dr. Liang, K. W. synthesize mitsugashiwalactone; Dr. Shiu, L. H. synthesize co
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Lee, Chin-Fa, and 李進發. "New Annulation Route to 2,3,5-trisubstituted Furans; Towards Conjugated Molecular Nanowires." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/81709432528077154931.

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博士<br>國立臺灣大學<br>化學研究所<br>90<br>Treatment of propargylic dithioacetals with organocuprates, then quenching with different electrophiles yields regioselectively substituted allenenyl or propargylic thioethers. Treatment of allenyl copper with an aldehyde followed by TFA leads to the 2,3,5-trisubstituted furan. The substitution in furan ring can be aliphatic or aromatic group. In this reaction, the thioether moiety is a good leaving group. Starting from the dialdehydes, oligoaryls having two furan moieties were obtained in one pot. A wide range of substituents having different function
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Yu-Shiou, Fan, and 范宇琇. "Synthesis of Trisubstituted Oxazoles or Highly Functional Benzofurans via Intramolecular Wittig Reaction." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/13507508495908211305.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>Oxazole derivatives are of great importance in organic chemistry. Based on our success in development of an efficient method to construct the furan ring utilizing an intramolecular Wittig reaction, we reported a facile metal-free approach for the synthesis of trisubstituted oxazoles starting from N-acyl imines, Bu3P, and acyl chlorides in the presence of Et3N. The reaction mechanism is proposed to undergo the Michael addition of PBu3 toward N-acyl imines followed by O-acylation, deprotonation and finally intramolecular Wittig reaction to furnish corresponding ox
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Liu, Hsuan-Yi, and 劉軒儀. "One-pot Synthesis to 1,3,5-trisubstituted 1,2,4-triazole derivatives via 1,3-dipolar cycloaddition." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ww66t4.

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碩士<br>國立嘉義大學<br>應用化學系研究所<br>106<br>Derivatives of 1,2,4-triazoles are found in Marijuana, in which 113 different kind of derivatives have been confirmed. Those compounds have potential therapeutic effect such as antimetic, analgesic, antiglaucoma, inflammation, obesity have been reported. The most well know activity of cannabinoid are Tetrahydrocannabinol (THC) and Canabidal, which are maily psychotic and anti-inflammatory. This main perpose of this study is the synthesis of 1,2,4-triazole derivative for the treatment of obesity, in which R3 is mainly hexyl、6-azidohex-2-yn-1-yl and 3-cyclohexy
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HsieH, Tai-ran, та 謝泰然. "Synthetic studies toward 3,4,5-trisubstituted-piperidine and cis-4-substituted-5-amino-δ-lactam". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/86407437083433455480.

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Boudou, Marine [Verfasser]. "Asymmetric synthesis of trisubstituted isoindolines and tetrahydropalmatine via tandem 1,2-addition,cyclisation / vorgelegt von Marine Boudou." 2005. http://d-nb.info/975637134/34.

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Chang, An-Tai, and 張安泰. "The Trisubstituted Derivatives of Spirally Configured cis-Stilbene/Fluorene Hybrid Templates for Organic Light Emitting Diode." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/j83wb9.

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碩士<br>國立清華大學<br>化學系所<br>106<br>In this thesis, a series of 3,7,2’/3’-trisubstituent spirally configured cis-stilbene/fluorene hybird derivatives were synthesized. The photoelectronic properties of these compounds have been tuned by modifying different functional group. These compounds were applied as electron transport layers, blue-emitting dopent and host materials. Pyridine and benzonitrile groups were chosen to modify theelectron-transport properties of the cis-stilbene/fluorine hybrid core. The green phosphorescent device fabricated using (mCNF)2S3PY as electron transport layer showed the
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