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Journal articles on the topic 'Triterpenoid'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Song, Lijun, Li Zhang, Long Xu, et al. "Optimized Extraction of Total Triterpenoids from Jujube (Ziziphus jujuba Mill.) and Comprehensive Analysis of Triterpenic Acids in Different Cultivars." Plants 9, no. 4 (2020): 412. http://dx.doi.org/10.3390/plants9040412.

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Triterpenoid compounds are one of the main functional components in jujube fruit. In this study, the optimal process for ultrasound-assisted extraction (UAE) of total triterpenoids from jujube fruit was determined using response surface methodology (RSM). The optimal conditions were as follows: temperature of 55.14 °C, ethanol concentration of 86.57%, time of 34.41 min, and liquid-to-solid ratio of 39.33 mL/g. The triterpenoid yield was 19.21 ± 0.25 mg/g under optimal conditions. The triterpenoid profiles and antioxidant activity were further analyzed. Betulinic acid, alphitolic acid, maslinic

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2

Numonov, Sodik, Farukh Sharopov, Muhammad Nasimullah Qureshi, et al. "The Ursolic Acid-Rich Extract of Dracocephalum heterophyllum Benth. with Potent Antidiabetic and Cytotoxic Activities." Applied Sciences 10, no. 18 (2020): 6505. http://dx.doi.org/10.3390/app10186505.

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Pentacyclic triterpenoids are one of the main functional components in Dracocephalum heterophyllum. In this study the optimal process, the fairly simple and accessible extraction and purification of triterpenoids of D. heterophyllum, was developed by a remaceration method. Remaceration is characterized by minimal loss of biologically active compounds on diffusion, which contributes to the largest depletion of raw materials. The triterpenoid yield was 2.4% under optimal conditions which was enhanced to 98.03% after purification. The triterpenoid profiles and their anticancer and antidiabetic ac

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3

Wen, Cuiping, Zhong Zhang, Qianqian Shi, et al. "Methyl Jasmonate- and Salicylic Acid-Induced Transcription Factor ZjWRKY18 Regulates Triterpenoid Accumulation and Salt Stress Tolerance in Jujube." International Journal of Molecular Sciences 24, no. 4 (2023): 3899. http://dx.doi.org/10.3390/ijms24043899.

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Triterpenoids are important, pharmacologically active substances in jujube (Ziziphus jujuba Mill.), and play an important role in the plant’s resistance to abiotic stress. However, regulation of their biosynthesis, and the underlying mechanism of their balance with stress resistance, remain poorly understood. In this study, we screened and functionally characterized the ZjWRKY18 transcription factor, which is associated with triterpenoid accumulation. The transcription factor is induced by methyl jasmonate and salicylic acid, and its activity was observed by gene overexpression and silencing e

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4

Fang, Zhu-Jun, Sheng-Nan Shen, Jia-Min Wang, et al. "Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes." Molecules 24, no. 1 (2019): 187. http://dx.doi.org/10.3390/molecules24010187.

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Four previously undescribed compounds, including three rarely occurring seco-dammarane triterpenoid glycosides and a pentacyclic triterpenic acid, were isolated from a 70% ethanol extract of the leaves of Cyclocarya paliurus (Juglandaceae), along with eleven known triterpenoids. Their structures were determined by spectroscopic techniques, including 2D NMR and HRESIMS, as well as chemical methods. Among them, several triterpenoids enhanced insulin stimulated glucose uptake in both 3T3-L1 adipocytes and C2C12 myotubes. Furthermore, compound 1 dose-dependently increased glucose uptake through ac

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5

Chang, Te-Sheng, Chien-Min Chiang, Tzi-Yuan Wang, et al. "One-Pot Bi-Enzymatic Cascade Synthesis of Novel Ganoderma Triterpenoid Saponins." Catalysts 11, no. 5 (2021): 580. http://dx.doi.org/10.3390/catal11050580.

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Ganoderma lucidum is a medicinal fungus whose numerous triterpenoids are its main bioactive constituents. Although hundreds of Ganoderma triterpenoids have been identified, Ganoderma triterpenoid glycosides, also named triterpenoid saponins, have been rarely found. Ganoderic acid A (GAA), a major Ganoderma triterpenoid, was synthetically cascaded to form GAA-15-O-β-glucopyranoside (GAA-15-G) by glycosyltransferase (BtGT_16345) from Bacillus thuringiensis GA A07 and subsequently biotransformed into a series of GAA glucosides by cyclodextrin glucanotransferase (Toruzyme® 3.0 L) from Thermoanaero

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6

Liu, Zengcai, Ruipeng Liu, Xinyu Tong, and Li Zou. "New Insights into Methyl Jasmonate Regulation of Triterpenoid Biosynthesis in Medicinal Fungal Species Sanghuangporusbaumii (Pilát) L.W. Zhou & Y.C. Dai." Journal of Fungi 8, no. 9 (2022): 889. http://dx.doi.org/10.3390/jof8090889.

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Triterpenoids are secondary metabolites produced by the fungus Sanghuangporus baumii that have important pharmacological activities. However, the yield of triterpenoids is low and cannot meet market demand. Here, we treated S. baumii with several concentrations of MeJA (methyl jasmonate) and found that the total triterpenoid content was highest (23.31 mg/g) when the MeJA concentration was 250 μmol/L. qRT-PCR was used to quantify the transcription of five key genes involved in triterpenoid biosynthesis. The results showed that the relative transcription of most genes increased with increasing M

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7

Supratman, Unang, Fajar Fauzi Abdullah, Kindi Farabi, Nurlelasari Nurlelasari, Khalijah Awang, and Mohamad Azlan Nafiah. "Triterpenoids From Swietenia mahagoni L Jacq. and Their Cytotoxic Activity against MCF-7 Breast Cancer and CV-1 Normal Kidney Cell Lines." Molekul 19, no. 2 (2024): 227. http://dx.doi.org/10.20884/1.jm.2024.19.2.9358.

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ABSTRACT. Triterpenoid is a group of natural products with various remarkable activities, including cytotoxic. One of the sources for this type of compounds is Swietenia genus belong to Meliaceae family. This genus known to contains various secondary metabolites including limonoids, flavonoids, and triterpenoids. Especially for triterpenoid, there is limited report on isolation as well as biological activity from Swietenia genus, such as Swietenia mahagoni. In this research, three triterpenoid compounds have been successively isolated and identified from n-hexane extract, namely, (-)-leucophyl

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8

Woźniak, Łukasz, Anna Szakiel, Agnieszka Głowacka, Elżbieta Rozpara, Krystian Marszałek, and Sylwia Skąpska. "Triterpenoids of Three Apple Cultivars—Biosynthesis, Antioxidative and Anti-Inflammatory Properties, and Fate during Processing." Molecules 28, no. 6 (2023): 2584. http://dx.doi.org/10.3390/molecules28062584.

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Triterpenoids are a group of secondary plant metabolites, with a remarkable pharmacological potential, occurring in the cuticular waxes of the aerial parts of plants. The aim of this study was to analyze triterpenoid variability in the fruits and leaves of three apple cultivars during the growing season and gain new insights into their health-promoting properties and fate during juice and purée production. The identification and quantification of the compounds of interest were conducted using gas chromatography coupled with mass spectrometry. The waxes of both matrices contained similar analyt

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9

Sun, Caowen, Shengzuo Fang, and Xulan Shang. "Triterpenoids Biosynthesis Regulation for Leaf Coloring of Wheel Wingnut (Cyclocaryapaliurus)." Forests 12, no. 12 (2021): 1733. http://dx.doi.org/10.3390/f12121733.

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Cyclocaryapaliurus leaves are rich in triterpenoids with positive results in the treatment of diabetes, antioxidation, and scavenging free radicals. C. paliurus red leaves have been found to contain higher flavonoids including anthocyanin, however, the triterpenoids accumulation pattern is still unclear. For the purpose of researching the triterpenoid accumulating mechanism during red new leaf development, transcriptome and metabolome analysis was conducted during C. paliurus the red leaf development process. The results uncovered that most triterpenoid ingredients were found to accumulate dur

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10

Kim, Jaecheol, Si Chang Yang, Ah Young Hwang, Hyunnho Cho, and Keum Taek Hwang. "Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines." Molecules 25, no. 18 (2020): 4066. http://dx.doi.org/10.3390/molecules25184066.

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The objective of this study was to determine the composition of triterpenoids in the extracts from the inner and outer parts of Inonotus obliquus and to evaluate their anti-proliferative activity against cancer cell lines (HT-29, AGS, MCF-7, and PC3). Inner and outer parts of I. obliquus were extracted with 80% methanol for 24 h. The extract was fractionated by Diaion HP-20 resin to obtain the triterpenoid fraction. Composition of triterpenoids in the fraction was analyzed by HPLC and LC-ESI-MS. Anti-proliferative activity was evaluated by MTT assay against cancer cell lines. Inotodiol and tra

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11

Aliffia Dwi Rahma, Hanifah Ismayfatin, Yulianti Khasanah, Aditiya Rizky Putra Abimanyu, and Himyatul Hidayah. "Identification of Tannin, Triterpenoid, and Flavonoid Function Groups of Jamblang Plants (Syzygium cumini): A Systematic Literature Review." Eureka Herba Indonesia 5, no. 1 (2023): 377–82. http://dx.doi.org/10.37275/ehi.v5i1.102.

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Identification of the functional groups of tannins, triterpenoids, and flavonoids in jamblang is important to determine the type and content of bioactive compounds found in jamblang. By knowing the type and content of these bioactive compounds, the potential of jamblang as a traditional medicine can be further optimized. This study aims to explore the identification of tannin, triterpenoid, and flavonoid functional groups in jamblang. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the identi

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12

De Oliveira Campos, Aline, Mark D. Harrison, David L. Marshall, and Peter James Strong. "Distributions of Lanostene-Derived Triterpenoids and Glucan Content in the Fruiting Bodies of the Australian Ganoderma Species." Journal of Fungi 10, no. 10 (2024): 723. http://dx.doi.org/10.3390/jof10100723.

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Lanostene-derived triterpenoids and β-glucans are important metabolites in Ganoderma mushrooms associated with benefits to human health. The medicinal value of the Australian Ganoderma species remains unclear, with no data on triterpenoid distribution or glucan content. In the present study, 22 Australian Ganoderma specimens were analyzed for triterpenoid and glucan contents. Thirty-two triterpenoids were identified in the fruiting bodies of 19 of the specimens. Distinct patterns in triterpenoid distribution between laccate and matte fruiting bodies were observed, leading to the classification

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13

Si, Longlong, Kun Meng, Zhenyu Tian, et al. "Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes." Science Advances 4, no. 11 (2018): eaau8408. http://dx.doi.org/10.1126/sciadv.aau8408.

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A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its constitutive heptad repeat-2 (HR2), a prevalent α-helical coil in class I viral fusion proteins. Triterpenoids inhibit the entry of Ebola, Marburg, HIV, and influenza A viruses with distinct structure-activity relationships. Specifically, triterpenoid probes capture the viral enve

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14

Nguyen Duc Tien and Nguyen Thi Huyen. "EFFECT OF SOLVENT IN COMBINATION WITH ULTRASONIC WAVE ASSISTANCE ON TRITERPENOID EXTRACTION FROM RED LINGZHI MUSHROOM (Ganodermalucidum)." Pakistan Journal of Biotechnology 19, no. 1 (2022): 23–28. http://dx.doi.org/10.34016/pjbt.2022.19.1.23.

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Triterpenoid is one of the compounds that contribute tored lingzhi mushroom's major significant therapeutic activities (G. lucidum). Triterpenoids have anti-allergic, anti-cancer, anti-tumor, and anti-aging effects, enhance oxygen utilization, free radical scavenging, lowerblood pressure, inhibit cholesterol biosynthesis, and enhance liver function and blood pressure, inhibit cholesterol biosynthesis, and improve liver functionetc. The beneficial effects of triterpenoids in Ganoderma lucidum on human health have generated interest in developing methods for extracting them from the fruit bodies

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15

Xu, Hou-Chao, Kun Hu, Xiao-Huo Shi, et al. "Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea." Organic Chemistry Frontiers 6, no. 10 (2019): 1619–26. http://dx.doi.org/10.1039/c9qo00281b.

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16

Tong, Xinyu, Ying Yu, Jin Huang, et al. "Metabolic Response of Sanghuangporus baumii to Zn2+ Induction and Biosynthesis of a Key Pharmacological Component: Triterpenoid." Microorganisms 13, no. 5 (2025): 1067. https://doi.org/10.3390/microorganisms13051067.

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Triterpenoids derived from Sanghuangporus baumii exhibit potent antitumor activity, but their yields under natural conditions are relatively low due to their status as secondary metabolites. In this study, we investigated the effects of Zn²⁺ induction on the growth and triterpenoid biosynthesis of S. baumii. The results showed that 0.5 mM Zn²⁺ significantly enhanced the mycelial growth rate (0.43 ± 0.004 cm/d) and biomass (4.8 ± 0.024 g/L), representing increases of 8.71% and 16.95%, respectively, compared with the Zn0 group. This result was mainly caused by an increase in the soluble sugar co

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17

Liang, Xiaoqin, Peng Niu, Jun Li, Xinlan Guan, Yanjun Zhang, and Jian Li. "Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand." Molecules 28, no. 4 (2023): 1658. http://dx.doi.org/10.3390/molecules28041658.

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Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an

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18

Zhou, Pinhan, Juan Wang, Chaohui Li, et al. "Multi-Omics and Functional Insights into Triterpenoid Biosynthesis Pathways in Neopicrorhiza scrophulariiflora (Pennell) D.Y.Hong." Plants 14, no. 10 (2025): 1562. https://doi.org/10.3390/plants14101562.

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Neopicrorhiza scrophulariiflora (Pennell) D.Y.Hong, an endangered perennial herb, is rich in triterpenes, iridoids, and phenolic compounds, which exhibit significant pharmacological effects. However, the molecular mechanisms of triterpenoid biosynthesis in N. scrophulariiflora remain unclear. Here, transcriptomic and metabolomic analyses were performed to investigate the triterpene content in different tissues and the expression patterns of key enzyme-encoding genes related to triterpenoid biosynthesis. We functionally characterized eight upstream oxidosqualene cyclases (OSCs) involved in trit

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Dashbaldan, Soyol, Cezary Pączkowski, and Anna Szakiel. "Variations in Triterpenoid Deposition in Cuticular Waxes during Development and Maturation of Selected Fruits of Rosaceae Family." International Journal of Molecular Sciences 21, no. 24 (2020): 9762. http://dx.doi.org/10.3390/ijms21249762.

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The process of fruit ripening involves many chemical changes occurring not only in the mesocarp but also in the epicarp, including changes in the triterpenoid content of fruit cuticular waxes that can modify the susceptibility to pathogens and mechanical properties of the fruit surface. The aim of the study was the determination of the ripening-related changes in the triterpenoid content of fruit cuticular waxes of three plant species from the Rosaceae family, including rugosa rose (Rosa rugosa), black chokeberry (Aronia melanocarpa var. “Galicjanka”) and apple (Malus domestica var. “Antonovka

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20

Huo, Yonghong, Dongchao Liu, Qin Yang, Changyan Sun, Zhanbin Wang, and Dehai Li. "Transcriptional Responses for Biosynthesis of Triterpenoids in Exogenous Inducers Treated Inonotus Hispidus Using RNA-Seq." Molecules 27, no. 23 (2022): 8541. http://dx.doi.org/10.3390/molecules27238541.

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Inonotus hispidus is a traditional medicinal that grows in Northeast China and produces various economically important compounds, including polysaccharide compounds and terpenoids; triterpenoid saponins is the main bioactive component. Our research group has found that the accumulation of triterpenoid was affected by exogenous inducers. Experimental results showed that treatment with methyl jasmonate (MeJA) and oleic acid significantly increased the triterpenoid content of I. hispidus. However, how exogenous inducers enhance production of secondary metabolites in I. hispidus is not well unders

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Rahman, Rahman, Gusti Abdul Rahmat Thamrin, and Kurdiansyah Kurdiansyah. "UJI FITOKIMIA TUMBUHAN JELATANG GAJAH (Dendrocnide stimulans) DI KAWASAN HUTAN DENGAN TUJUAN KHUSUS UNIVERSITAS LAMBUNG MANGKURAT." Jurnal Sylva Scienteae 4, no. 3 (2021): 501. http://dx.doi.org/10.20527/jss.v4i3.3751.

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The purpose of this study was to qualitatively identify active chemical compounds, namely the content of alkaloids, flavonoids, steroids, triterpenoids, tannins, saponins, and quinones, in the roots, bark and leaves of Jelatang Gajah. The method used is phytochemical screening by identifying using various active compounds in the simplicia of the Jelatang Gajah plant. Flavonoid chemical compounds in this test were not detected, because the solution did not change color. Steroid chemical compounds from 3 (three) times the repetition of the section show a strong / sharp indication value (++) whic

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Shende, Mulchand A., Minakshi S. More, and Rajendra P. Marathe. "Development and Evaluation of Terminalia Arjuna Loaded Phytosome for Bioavailability Enhancement." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 2 (2018): 4012–20. http://dx.doi.org/10.37285/ijpsn.2018.11.2.2.

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Present work was aimed to develop and investigate phosphatidylcholinatedphytosome system based on triterpenoid fraction of Terminalia Arjuna (TFTA) for secure and efficient delivery of triterpenoid to enhanced bioavailability. Microwave-assisted extraction (MAE) a green method with a significant reduction in extraction time and organic solvent consumption has been selected and successful extraction of triterpenoids with good yield. Planterosomes a novel carrier for drug delivery of triterpenoid fraction of Terminalia Arjuna were effectively fabricated with a specified molar ratio of 7:3 of TFT

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Karalai, Chatchanok, and Surat Laphookhieo. "Triterpenoid Esters from Bruguiera cylindrica." Australian Journal of Chemistry 58, no. 7 (2005): 556. http://dx.doi.org/10.1071/ch05010.

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Three new pentacyclic triterpenoid esters 1–3 together with six known lupane-type triterpenoids were isolated from Bruguiera cylindrica. The structures of the new compounds were elucidated by spectroscopic methods and were characterized as 3α-E-coumaroyllupeol 1, 3α-Z-coumaroyllupeol 2, and 3α-E-caffeoyltaraxerol 3.

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Baek, Seungeun, Jong-Eun Han, Thanh-Tam Ho, and So-Young Park. "Development of Hairy Root Cultures for Biomass and Triterpenoid Production in Centella asiatica." Plants 11, no. 2 (2022): 148. http://dx.doi.org/10.3390/plants11020148.

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Centella asiatica (Apiaceae) is a tropical/subtropical medicinal plant, which contains a variety of triterpenoids, including madecassoside, asiaticoside, madecassic acid, and asiatic acid. In this study, we tested the efficiency of hairy root (HR) induction in C. asiatica from leaf and petiole explants. Leaves and petioles collected from C. asiatica plants were suspended in agro-stock for 30 min and co-cultured with Agrobacterium rhizogenes for 3 days to induce HR formation. The transformation efficiency of leaf and petiole explants was approximately 27% and 12%, respectively. A total of 36 HR

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Vilkickyte, Gabriele, Vilma Petrikaite, Mindaugas Marksa, Liudas Ivanauskas, Valdas Jakstas, and Lina Raudone. "Fractionation and Characterization of Triterpenoids from Vaccinium vitis-idaea L. Cuticular Waxes and Their Potential as Anticancer Agents." Antioxidants 12, no. 2 (2023): 465. http://dx.doi.org/10.3390/antiox12020465.

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Fruit and leaf cuticular waxes are valuable source materials for the isolation of triterpenoids that can be applied as natural antioxidants and anticancer agents. The present study aimed at the semi-preparative fractionation of triterpenoids from cuticular wax extracts of Vaccinium vitis-idaea L. (lingonberry) leaves and fruits and the evaluation of their cytotoxic potential. Qualitative and quantitative characterization of obtained extracts and triterpenoid fractions was performed using HPLC-PDA method, followed by complementary analysis by GC-MS. For each fraction, cytotoxic activities towar

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Tran Chi Hai, Mai Tien Hung, Chu Thi Nga, et al. "ENZYME-ASSISTED EXTRACTION OF TRITERPENOID AND PHENOLIC COMPOUNDS FROM Rubus alceaefolius Poir LEAVES." Tạp chí Khoa học Đại học Công Thương 24, no. 3 (2024): 3–13. http://dx.doi.org/10.62985/j.huit_ojs.vol24.no3.81.

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The leaves of Rubus alceaefolius Poir primarily consist of phenolic and triterpenoid compounds, which possess a variety of biological activities beneficial to human health. This research aimed to explore the impact of enzyme-assisted extraction conditions on the recovery of triterpenoid and phenolic compounds from Rubus alceaefolius Poir leaves. Factors considered in the enzymatic treatment process with Viscozyme L cellulase included the solid-to-water ratio (1:15-1:45 w/v), enzyme concentration (0.5-3.5%), temperature (40-60 °C), and extraction duration (30-180 min). The results suggested tha

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Chang, Te-Sheng. "Glycosylation of Ganoderic Acid F by Bacillus Glycosyltransferase." Agrochemicals 1, no. 1 (2022): 17–21. http://dx.doi.org/10.3390/agrochemicals1010003.

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Ganoderma lucidum is a medicinal fungus and has been used for improvements of health or prevention of certain diseases in Asia for thousands of years. Despite numerous kinds of triterpenoids having been identified from G. lucidum, few natural Ganoderma triterpenoids exist in the form of glycosides (saponins). To expand the diversity of Ganoderma triterpenoids and find rare Ganoderma saponins, ganoderic acid F (GAF), a Ganoderma triterpenoid, was biotransformed by a glycosyltransferase (BsGT110) from Bacillus subtilis ATCC (American type culture collection) 6633. The results showed that BsGT110

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Khwaza, Vuyolwethu, Sithenkosi Mlala, Opeoluwa O. Oyedeji, and Blessing A. Aderibigbe. "Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery." Molecules 26, no. 9 (2021): 2401. http://dx.doi.org/10.3390/molecules26092401.

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Pentacyclic triterpenoids are well-known phytochemicals with various biological activities commonly found in plants as secondary metabolites. The wide range of biological activities exhibited by triterpenoids has made them the most valuable sources of pharmacological agents. A number of novel triterpenoid derivatives with many skeletal modifications have been developed. The most important modifications are the formation of analogues or derivatives with nitrogen-containing heterocyclic scaffolds. The derivatives with nitrogen-containing heterocyclic compounds are among the most promising candid

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Li, Liangqun, Mei Peng, Yanfang Yan, et al. "Combined Metabolite and Transcriptomic Profiling Unveil a Potential Gene Network Involved in the Triterpenoid Metabolism of Rose roxburghii." International Journal of Molecular Sciences 25, no. 10 (2024): 5517. http://dx.doi.org/10.3390/ijms25105517.

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Rose roxburghii, a horticulturally significant species within the Rosa genus of the Rosaceae family, is renowned for its abundance of secondary metabolites and ascorbate, earning it the title ‘king of vitamin C’. Despite this recognition, the mechanisms underlying the biosynthesis and regulation of triterpenoid compounds in R. roxburghii remain largely unresolved. In this study, we conducted high-performance liquid chromatography profiling across various organs of R. roxburghii, including fruit, root, stem, and leaves, revealing distinct distributions of triterpenoid compounds among different

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An, Gi-Hong, Jae-Gu Han, Hye-Sung Park, Gi-Ho Sung, and Ok-Tae Kim. "Identification of an Oxidosqualene Cyclase Gene Involved in Steroidal Triterpenoid Biosynthesis in Cordyceps farinosa." Genes 12, no. 6 (2021): 848. http://dx.doi.org/10.3390/genes12060848.

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Various fungi including Cordyceps farinosa, an entomopathogenic fungus, can produce steroidal triterpenoids. Protostadienol (protosta-17(20)Z,24-dien-3β-ol) is a precursor of steroidal triterpenoid compounds. To identify oxidosqualene cyclase (OSC) gene candidates involved in triterpenoid biosynthesis, genome mining was performed using Illumina sequencing platform. In the sequence database, two OSC genes, CfaOSC1 and CfaOSC2, in the genome of C. farinosa were identified. Predicted amino-acid sequences of CfaOSC2 shared 66% similarities with protostadienol synthase (OSPC) of Aspergillus fumigat

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Konda, Josepin P., Jainer P. Siampa, Trina E. Tallei, Billy J. Kepel, and Fatimawali Fatimawali. "Aktivitas Antioksidan Ekstrak Metanol Biji Langsat (Lansium domesticum var. pubescens) dan Duku (Lansium domesticum var. domesticum) dengan Metode DPPH." JURNAL ILMIAH SAINS 20, no. 2 (2020): 113. http://dx.doi.org/10.35799/jis.20.2.2020.28835.

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Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan aktivitas antioksidan ekstrak biji langsat dan duku dengan metode DPPH. Biji buah langsat dan buah duku diekstraksi menggunakan metode maserasi dengan pelarut metanol. Skrining fitokimia yang dilakukan meliputi uji alkaloid, flavonoid, tannin, triterpenoid, steroid dan saponin secara kualitatif dengan metode uji warna. Uji aktivitas antioksidan menggunakan metode DPPH dan vitamin C sebagai pembanding, serapan diukur menggunakan spektrofotometer UV-Vis pada panjang gelombang 517 nm. Skrining fitokimia pada ekstrak metanol biji la

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Wu, Jiumn-Yih, Hsiou-Yu Ding, Tzi-Yuan Wang, Yun-Rong Zhang, and Te-Sheng Chang. "Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases." International Journal of Molecular Sciences 22, no. 18 (2021): 9744. http://dx.doi.org/10.3390/ijms22189744.

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Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Ganoderma triterpenoids have already been identified, rare Ganoderma triterpenoid saponins were recently discovered. To create novel Ganoderma saponins, ganoderic acid G (GAG) was selected for biotransformation using four Bacillus glycosyltransferases (GTs) including BtGT_16345 from the Bacillus thuringiensis GA A07 strain and three GTs (BsGT110, BsUGT398, and BsUGT489) from the Bacillus subtilis ATCC 6633 strain. The results showed that BsUGT489 catalyzed the glycosylation of

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Bicalho, Keylla U., Mariana M. Santoni, Philipp Arendt, et al. "CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway." Plant and Cell Physiology 60, no. 11 (2019): 2510–22. http://dx.doi.org/10.1093/pcp/pcz144.

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Abstract The native Brazilian plant Maytenus ilicifolia accumulates a set of quinone methide triterpenoids with important pharmacological properties, of which maytenin, pristimerin and celastrol accumulate exclusively in the root bark of this medicinal plant. The first committed step in the quinone methide triterpenoid biosynthesis is the cyclization of 2,3-oxidosqualene to friedelin, catalyzed by the oxidosqualene cyclase friedelin synthase (FRS). In this study, we produced heterologous friedelin by the expression of M. ilicifolia FRS in Nicotiana benthamiana leaves and in a Saccharomyces cer

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Xue, Liang, Bianca Carreiro, Md Sagir Mia, Inke Paetau-Robinson, Christina Khoo, and Catherine Neto. "Pentacyclic Triterpenoid Content in Cranberry Raw Materials and Products." Foods 13, no. 19 (2024): 3136. http://dx.doi.org/10.3390/foods13193136.

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Cranberry fruit extracts have been shown to inhibit expression of pro-inflammatory cytokines in THP-1 cells and reduce colonic tumor burden and tissue inflammation in a mouse model of colitis. These activities are attributed to both the triterpenoid and polyphenol constituents of the fruit. The pentacyclic triterpenoids ursolic acid (UA), oleanolic acid (OA), corosolic acid (CA), maslinic acid (MA), and esters of UA and OA occur in the waxy layer of cranberry peel, and their content in cranberry products is likely to vary with the fruit source and processing methods. UPLC-MS (ultra performance

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Wijayanti, Laely, Rosidah Radam, and Siti Hamidah. "SENYAWA KIMIA AKTIF PADA DAUN NIPAH (Nyfa fruticans Wurmb)." Jurnal Sylva Scienteae 5, no. 6 (2022): 963. http://dx.doi.org/10.20527/jss.v5i6.7140.

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Nipah plants are plants that live in brackish water swamp ecosystems and river mouths. Nipah is often used for various household needs. Nipah contains active compounds that can become medicinal plants. This research has purpose to analyze active chemical compounds in three age of nipah leaves in young, medium, and old periode.This research was conducted at the Lambung Mangkurat Banjarbaru Forest Product Technology Laboratory. The study time was conducted for 4 including the stages of material preparation and equipment, laboratory analysis, data processing, preparation and writing of research r

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Wimmerová, Martina, Uladzimir Bildziukevich, and Zdeněk Wimmer. "Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents." Molecules 28, no. 23 (2023): 7718. http://dx.doi.org/10.3390/molecules28237718.

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The results of the most recent investigation of triterpenoid-based antiviral agents namely in the HIV-1 and HSV-1 treatment were reviewed and summarized. Several key historical achievements are included to stress consequences and continuity in this research. Most of the agents studied belong to a series of compounds derived from betulin or betulinic acid, and their synthetic derivative is called bevirimat. A termination of clinical trials of bevirimat in Phase IIb initiated a search for more successful compounds partly derived from bevirimat or designed independently of bevirimat structure. Su

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Giang, Phan Minh, Vu Thi Thu Phuong, and Truong Thi To Chinh. "A New Taraxastane-type Triterpenoid from Cleistocalyx Operculatus." Natural Product Communications 11, no. 1 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100110.

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Ten known compounds including a chalcone, a long-chain alcohol, two flavonols, and six triterpenoids/steroids together with a new taraxastane-type triterpenoid, named cleistocalyxin, were isolated from the leaves of Cleistocalyx operculatus. The structure of cleistocalyxin was determined on the basis of IR, MS and NMR spectroscopic methods.

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Szewczyk, K., R. Bonikowski, A. Maciąg-Krajewska, J. Abramek, and A. Bogucka-Kocka. "Lipophilic components and evaluation of the cytotoxic and antioxidant activities of Impatiens glandulifera Royle and Impatiens noli – tangere L. (Balsaminaceae)." Grasas y Aceites 69, no. 3 (2018): 270. http://dx.doi.org/10.3989/gya.0234181.

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The chemical composition of the lipophilic fractions of Impatiens glandulifera Royle and I. noli-tangere L. were analyzed by gas chromatography-mass spectrometry (GC-MS)., The study focused on the fatty acids, triterpenoids and sterols in the leaves, roots and seeds. Most of the identified compounds are new for these species. a-linolenic, oleic and palmitic acids were the most abundant in the fatty acid fractions, β-amyrin and 5a-lup-20(29)-en-3β-ol in the triterpenoid fractions, and β-sitosterol, spinasterol and chondrillasterol in the sterol fractions. The fatty acid and triterpenoid fractio

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Markowski, Michał, Abdulwadood Shakir Mahmood Alsoufi, Anna Szakiel, and Marek Długosz. "Effect of Ethylene and Abscisic Acid on Steroid and Triterpenoid Synthesis in Calendula officinalis Hairy Roots and Saponin Release to the Culture Medium." Plants 11, no. 3 (2022): 303. http://dx.doi.org/10.3390/plants11030303.

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Phytohormones (plant growth regulators) can be applied as efficient elicitors to enhance the productivity of plant in vitro cultures, due to their significance in regulating the plant metabolism and strong influence on plant defense responses. In the present study, the effects of exogenous ethylene (ETY, applied in the form of ethephon as an ethylene-generating agent) and abscisic acid (ABA) on the synthesis of triterpenoids and steroids in Calendula officinalis hairy roots were investigated. ABA appeared to be an efficient elicitor of the biosynthesis of triterpenoid oleanolic acid (almost tw

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Zhai, Qiao Li, Ya Guang Zhan, Dao Qi Xu, Xiao Dong Wang, and Gui Zhi Fan. "Significant Enhancement of Triterpenoids Production by Phomopsis Elicitors in Cell Suspension Cultures of Betula Platyphylla Suk." Advanced Materials Research 335-336 (September 2011): 105–10. http://dx.doi.org/10.4028/www.scientific.net/amr.335-336.105.

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58 fungal elicitors prepared from the endophytic fungi isolated from inner bark of B. platyphylla Suk. were examined to determine their effects on the growth and triterpenoid production in suspension cultures of Betula platyphylla Suk. cells. The results showed that different fungal elicitors could cause diversely stimulating effects. Among the fungal elicitors tested, BE58 stimulated the highest triterpenoids yield with 15.90 mg•L-1 and 183.72% higher than the control. The experiment also affirmed from mRNA level that triterpenoid was indeed accumulated in suspension culture of birch cells tr

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Alsoufi, Abdulwadood Shakir Mahmood, Cezary Pączkowski, Marek Długosz, and Anna Szakiel. "Influence of Selected Abiotic Factors on Triterpenoid Biosynthesis and Saponin Secretion in Marigold (Calendula officinalis L.) in Vitro Hairy Root Cultures." Molecules 24, no. 16 (2019): 2907. http://dx.doi.org/10.3390/molecules24162907.

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The aim of the study was the evaluation of the efficiency of selected abiotic elicitors, i.e., silver and cadmium ions, ultrasound, and UV-C irradiation, in the stimulation of triterpenoid biosynthesis, accumulation, and saponin secretion in Calendula officinalis hairy root cultures. Apart from the possible enhancement of triterpenoid production, the relationship between primary and secondary metabolism (represented respectively by sterols and pentacyclic triterpenes), modifications of the sterol compositional profile, and fluctuations in the total triterpenoid content were monitored in the pe

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Claereboudt, Emily J. S., Guillaume Caulier, Corentin Decroo, et al. "Triterpenoids in Echinoderms: Fundamental Differences in Diversity and Biosynthetic Pathways." Marine Drugs 17, no. 6 (2019): 352. http://dx.doi.org/10.3390/md17060352.

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Echinoderms form a remarkable phylum of marine invertebrates that present specific chemical signatures unique in the animal kingdom. It is particularly the case for essential triterpenoids that evolved separately in each of the five echinoderm classes. Indeed, while most animals have Δ5-sterols, sea cucumbers (Holothuroidea) and sea stars (Asteroidea) also possess Δ7 and Δ9(11)-sterols, a characteristic not shared with brittle stars (Ophiuroidea), sea urchins (Echinoidea), and crinoids (Crinoidea). These particular Δ7 and Δ9(11) sterols emerged as a self-protection against membranolytic saponi

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Mierina, Inese, Reinis Vilskersts, and Māris Turks. "Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research." Current Medicinal Chemistry 27, no. 8 (2020): 1308–36. http://dx.doi.org/10.2174/0929867325666180530095657.

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Birch-bark triterpenoids and their semi-synthetic derivatives possess a wide range of biological activities including cytotoxic effects on various tumor cell lines. However, due to the low solubility and bioavailability, their medicinal applications are rather limited. The use of various nanotechnology-based drug delivery systems is a rapidly developing approach to the solubilization of insufficiently bioavailable pharmaceuticals. Herein, the drug delivery systems deemed to be applicable for birch-bark triterpenoid structures are reviewed. The aforementioned disadvantages of birch-bark triterp

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Luringunusa, Ekklesia, Grace Sanger, Deiske A. Sumilat, Roike Iwan Montolalu, Lena J. Damongilala, and Verly Dotulong. "Qualitative Phytochemical Analysis of Gracilaria verrucosa from North Sulawesi Waters." Jurnal Ilmiah PLATAX 11, no. 2 (2023): 551–63. http://dx.doi.org/10.35800/jip.v11i2.48777.

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The research aims to determine the phytochemical content such as phenolics, flavonoids, tannins, saponins, alkaloids, steroids, and triterpenoids found in the seaweed G. verrucosa. Seaweed G. verrucosa taken from the waters of North Sulawesi, Nain Village, North Minahasa, was extracted by maceration for 24 hours at room temperature, repeated 3 times using 96% ethanol solvent. The analysis in this study consisted of seven test parameters such as phenolic compounds, flavonoids, tannins, saponins, steroids, triterpenoids, and alkaloids. The results of the analysis showed that the secondary metabo

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Yu, Jin-Hai, Zhi-Pu Yu, Yin-Yin Wang, et al. "Triterpenoids and triterpenoid saponins from Dipsacus asper and their cytotoxic and antibacterial activities." Phytochemistry 162 (June 30, 2019): 241–49. https://doi.org/10.1016/j.phytochem.2019.03.028.

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Yu, Jin-Hai, Yu, Zhi-Pu, Wang, Yin-Yin, Bao, Jie, Zhu, Kong-Kai, Yuan, Tao, Zhang, Hua (2019): Triterpenoids and triterpenoid saponins from Dipsacus asper and their cytotoxic and antibacterial activities. Phytochemistry 162: 241-249, DOI: 10.1016/j.phytochem.2019.03.028, URL: http://dx.doi.org/10.1016/j.phytochem.2019.03.028

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Faustino, Célia, Noélia Duarte, and Lídia Pinheiro. "Triterpenes Drug Delivery Systems, a Modern Approach for Arthritis Targeted Therapy." Pharmaceuticals 17, no. 1 (2023): 54. http://dx.doi.org/10.3390/ph17010054.

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Arthritis is a major cause of disability. Currently available anti-arthritic drugs, such as disease-modifying anti-rheumatic drugs (DMARDs), have serious side-effects associated with long-term use. Triterpenoids are natural products with known anti-inflammatory properties, and many have revealed efficiency against arthritis both in vitro and in vivo in several animal models, with negligible cytotoxicity. However, poor bioavailability due to low water solubility and extensive metabolism upon oral administration hinder the therapeutic use of anti-arthritic triterpenoids. Therefore, drug delivery

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Chang, Te-Sheng, Chien-Min Chiang, Tzi-Yuan Wang, Chun-Hsien Lee, Yu-Wen Lee, and Jiumn-Yih Wu. "New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish." Molecules 23, no. 9 (2018): 2345. http://dx.doi.org/10.3390/molecules23092345.

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Functional bacteria that could biotransform triterpenoids may exist in the diverse microflora of fish intestines. Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum. In studying the microbial biotransformation of GAA, dozens of intestinal bacteria were isolated from the excreta of zebrafish. The bacteria’s ability to catalyze GAA were determined using ultra-performance liquid chromatography analysis. One positive strain, GA A07, was selected for functional studies. GA A07 was confirmed as Bacillus sp., based on the DNA sequences of the 16S rRNA gene. The

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Rajab, Mohamed. "In Silico Structure-Activity Study of Selected Triterpenoids as Potential Inhibitors of Mycolic Acid Transporter of Mycobacterial MmpL3 Receptor Protein." Sciences of Phytochemistry 3, no. 2 (2024): 82–90. http://dx.doi.org/10.58920/sciphy0302240.

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Structural features of the triterpenoid skeleton that are necessary for antimycobacterial activity are not well understood. Following the isolation of the triterpenoids ergosterol-5,8-endoperoxide, 6β-hydroxykulactone, 12β-hydroxykulactone, (24R)-24,25-epoxycycloartan-3-one and (3β,24R)-24,25-epoxycycloartan-3-ol, and (3β,24R)-24,25-epoxycycloartan-3-acetate with varying antimycobacterial activity ranging between MIC of 1 µg/ml to128 µg/ml prompted us to study this class of compounds further to shade light on the structural features necessary for their antimycobacterial activity. This in silic

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Venter, Pieter, Kholofelo Malemela, Vusi Mbazima, Leseilane J. Mampuru, Christo J. F. Muller, and Sylvia Riedel. "An RP-LC-UV-TWIMS-HRMS and Chemometric Approach to Differentiate between Momordicabalsamina Chemotypes from Three Different Geographical Locations in Limpopo Province of South Africa." Molecules 26, no. 7 (2021): 1896. http://dx.doi.org/10.3390/molecules26071896.

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Momordica balsamina leaf extracts originating from three different geographical locations were analyzed using reversed-phase liquid chromatography (RP-LC) coupled to travelling wave ion mobility (TWIMS) and high-resolution mass spectrometry (HRMS) in conjunction with chemometric analysis to differentiate between potential chemotypes. Furthermore, the cytotoxicity of the three individual chemotypes was evaluated using HT-29 colon cancer cells. A total of 11 molecular species including three flavonol glycosides, five cucurbitane-type triterpenoid aglycones and three glycosidic cucurbitane-type t

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Hidayah, Nur, Ritbey Ruga, and Chairul Saleh. "Anti-Inflammatory Effect Of Extract And Fractions Of Gaharu (Aquilaria malaccensis Lamk.) Leaves." JURNAL KIMIA MULAWARMAN 21, no. 1 (2023): 62. http://dx.doi.org/10.30872/jkm.v21i1.1022.

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Anti-inflammatory activity test of extract and fraction of gaharu leaf (Aquilaria malaccensis Lamk.) against protein denaturation inhibition in vitro has been carried out. This study aims to determine the percent inhibition of protein denaturation and the strength of anti-inflammatory activity of the concentrated methanol extract, ethyl acetate fraction, and methanol-water fraction of gaharu leaves (Aquilaria malaccensis Lamk.). BSA (Bovine serum albumin) is used as the protein to be heated. Diclofenac sodium was used as the positive control, and the negative control used the appropriate solve

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