Relevant bibliographies by topics / TRNA-derived small RNAs

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'TRNA-derived small RNAs'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "TRNA-derived small RNAs"

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Park, Joonhyeong, Se Hee Ahn, Myung Geun Shin, Hak Kyun Kim, and Suhwan Chang. "tRNA-Derived Small RNAs: Novel Epigenetic Regulators." Cancers 12, no. 10 (2020): 2773. http://dx.doi.org/10.3390/cancers12102773.

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An epigenetic change is a heritable genetic alteration that does not involve any nucleotide changes. While the methylation of specific DNA regions such as CpG islands or histone modifications, including acetylation or methylation, have been investigated in detail, the role of small RNAs in epigenetic regulation is largely unknown. Among the many types of small RNAs, tRNA-derived small RNAs (tsRNAs) represent a class of noncoding small RNAs with multiple roles in diverse physiological processes, including neovascularization, sperm maturation, immune modulation, and stress response. Regarding th
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Xu, Wei-Lin, Ye Yang, Yi-Dan Wang, Liang-Hu Qu, and Ling-Ling Zheng. "Computational Approaches to tRNA-Derived Small RNAs." Non-Coding RNA 3, no. 1 (2017): 2. http://dx.doi.org/10.3390/ncrna3010002.

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Jia, Hongyuan, and Linling Zhang. "tRNA-derived small RNAs in disease immunity." Theranostics 15, no. 1 (2025): 245–57. https://doi.org/10.7150/thno.102650.

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Di Fazio, Arianna, Margarita Schlackow, Sheng Kai Pong, Adele Alagia, and Monika Gullerova. "Dicer dependent tRNA derived small RNAs promote nascent RNA silencing." Nucleic Acids Research 50, no. 3 (2022): 1734–52. http://dx.doi.org/10.1093/nar/gkac022.

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Abstract In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves the cleavage of target messenger RNA (mRNA) or inhibition of translation in the cytoplasm, and transcriptional gene silencing (TGS), which is mediated by the establishment of repressive epigenetic marks at target loci. Transfer RNAs (tRNAs), which are essential for translation, can be processed into small ncRNAs, termed tRNA-derived small RNAs (tsRNAs). The biogenes
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Martinez, German, Sarah G. Choudury, and R. Keith Slotkin. "tRNA-derived small RNAs target transposable element transcripts." Nucleic Acids Research 45, no. 9 (2017): 5142–52. http://dx.doi.org/10.1093/nar/gkx103.

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Schorn, Andrea J., Michael J. Gutbrod, Chantal LeBlanc, and Rob Martienssen. "LTR-Retrotransposon Control by tRNA-Derived Small RNAs." Cell 170, no. 1 (2017): 61–71. http://dx.doi.org/10.1016/j.cell.2017.06.013.

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Garcia-Silva, Maria R., Florencia Cabrera-Cabrera, Roberta Ferreira Cura das Neves, Thaís Souto-Padrón, Wanderley de Souza, and Alfonso Cayota. "Gene Expression Changes Induced byTrypanosoma cruziShed Microvesicles in Mammalian Host Cells: Relevance of tRNA-Derived Halves." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/305239.

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At present, noncoding small RNAs are recognized as key players in novel forms of posttranscriptional gene regulation in most eukaryotes. However, canonical small RNA pathways seem to be lost or excessively simplified in some unicellular organisms includingTrypanosoma cruziwhich lack functional RNAi pathways. Recently, we reported the presence of alternate small RNA pathways inT. cruzimainly represented by homogeneous populations of tRNA- and rRNA-derived small RNAs, which are secreted to the extracellular medium included in extracellular vesicles. Extracellular vesicle cargo could be delivered
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Wang, Mengjun, Junfeng Guo, Wei Chen, Hong Wang, and Xiaotong Hou. "Emerging roles of tRNA-derived small RNAs in injuries." PeerJ 12 (October 24, 2024): e18348. http://dx.doi.org/10.7717/peerj.18348.

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tRNA-derived small RNAs (tsRNAs) are a novel class of small noncoding RNAs, precisely cleaved from tRNA, functioning as regulatory molecules. The topic of tsRNAs in injuries has not been extensively discussed, and studies on tsRNAs are entering a new era. Here, we provide a fresh perspective on this topic. We systematically reviewed the classification, generation, and biological functions of tsRNAs in response to stress, as well as their potential as biomarkers and therapeutic targets in various injuries, including lung injury, liver injury, renal injury, cardiac injury, neuronal injury, vascu
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Oberbauer, Vera, and Matthias Schaefer. "tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development." Genes 9, no. 12 (2018): 607. http://dx.doi.org/10.3390/genes9120607.

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Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during protein synthesis, tRNAs are also the source of a heterogeneous class of small RNAs, tRNA-derived small RNAs (tsRNAs). Occurrence and the relatively high abundance of tsRNAs has been noted in many high-throughput sequencing data sets, leading to largely correlative assumptions about their potential as biologically active entities. tRNAs are also the most modified RNAs in any cell type. Mutations in tRNA biogenesis
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Pereira, Marisa, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, and Ana R. Soares. "m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs." International Journal of Molecular Sciences 22, no. 6 (2021): 2941. http://dx.doi.org/10.3390/ijms22062941.

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Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. Recent evidence indicates that tsRNAs are also modified, however, the impact of tRNA epitranscriptome deregulation on tsRNAs generation is only now beginning to be uncovered. The 5-methylurid
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Dissertations / Theses on the topic "TRNA-derived small RNAs"

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Fernandes, Noémia Rita Alves. "Assessing silencing ability of tRNA derived fragments in zebrafish." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12621.

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Mestrado em Biologia Molecular e Celular<br>Since their discovery, small non-coding RNAs (sncRNAs) have been implicated in several eukaryotic regulatory mechanisms, such as post-transcriptional gene silencing, chromatin regulation and germline development. Although miRNAs constitute the most studied class of sncRNAs, the advent of high-throughput sequencing technologies allowed the discovery of new classes of sncRNA molecules. Recently, novel sncRNAs derived from tRNAs (tRNA-derived fragments) have been identified, whose biogenesis and functions are not yet well defined. In the last years the
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Monteiro, Daniel Girão. "Unravelling the profile and role of tRNA-derived small RNAs in Influenza A virus infection." Master's thesis, 2021. http://hdl.handle.net/10773/33431.

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Influenza A virus (IAV) is a respiratory virus that causes yearly seasonal epidemics and sporadic pandemic outbreaks. Annually, influenza epidemics result in 1 billion infections, 3–5 million cases of severe disease, and 300,000–500,000 deaths worldwide, according to the World Health Organization (WHO). Viruses are small opportunistic infectious agents that rely on the host cells machinery to propagate. Viruses lack, among others, key elements for genome replication and viral protein translation such as transfer ribonucleic acids (tRNAs). tRNAs are non-coding RNAs (ncRNAs) with a key role in
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Book chapters on the topic "TRNA-derived small RNAs"

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Keam, Simon P., Andrew Sobala, David T. Humphreys, Catherine M. Suter, and Gyorgy Hutvagner. "Computational Analysis, Biochemical Purification, and Detection of tRNA-Derived Small RNA Fragments." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0931-5_14.

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Oberbauer, Vera, Aleksej Drino, and Matthias R. Schaefer. "Determining small RNA-interacting proteomes using endogenously modified tRNA-derived RNAs." In Methods in Enzymology. Elsevier, 2024. https://doi.org/10.1016/bs.mie.2024.11.005.

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G. Fagan, Steven, and Shona Pfeiffer. "Emerging Roles of Non-Coding RNA in Neuronal Function and Dysfunction." In Recent Advances in Neurochemistry [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.101327.

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Advancements in RNA sequencing technologies in recent years have contributed greatly to our understanding of the transcriptome and the now widely recognized multifaceted functions of RNA. The discovery and functional analysis of an increasing number of novel small non-coding RNAs (ncRNAs) has highlighted their importance as critical regulators of gene expression and brain function. In particular, two diverse classes of ncRNAs, microRNAs (miRNAs) and tRNA-derived small RNAs (tsRNAs), are especially abundant in the nervous system and play roles in regulation of gene expression and protein transl
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Esposito, Carmela, Anamaria Buzoianu, Marina Cristodero, and Norbert Polacek. "Ribozyme-mediated expression of tRNA-derived small RNAs in bacteria." In Methods in Enzymology. Elsevier, 2024. https://doi.org/10.1016/bs.mie.2024.11.003.

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Muthukumar, Sowndarya, Silvia Tucciarone, Alexandre André Germanos, and Cristian Bellodi. "Functional characterization of tRNA-derived small RNAs in stem cells." In Methods in Enzymology. Elsevier, 2024. https://doi.org/10.1016/bs.mie.2024.11.015.

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Lucchesi, John C. "The role of non-coding RNAs." In Epigenetics, Nuclear Organization & Gene Function. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198831204.003.0006.

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Most of the genome is transcribed into non-coding transcripts that far exceed in number the transcripts of protein-coding genes. These RNAs are subdivided into different classes. Long non-coding RNAs (lncRNAs) are at least 200 nucleotides in length and are transcribed from promoter, coding, intergenic or enhancer regions (eRNAs). These RNAs repress or enhance the transcription of target genes by facilitating the interaction between promoters and enhancers or by interacting with transcription factors and targeting histone-modifying enzymes. Short non-coding RNAs include a diverse group of funct
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Balatti, Veronica, Yuri Pekarsky, and Carlo M. Croce. "Role of the tRNA-Derived Small RNAs in Cancer: New Potential Biomarkers and Target for Therapy." In Advances in Cancer Research. Elsevier, 2017. http://dx.doi.org/10.1016/bs.acr.2017.06.007.

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Kim, Dongjin, Hak Kyun Kim, and Mark A. Kay. "Functional analysis of tRNA-derived small RNA – Mediated translational regulation." In Methods in Enzymology. Elsevier, 2025. https://doi.org/10.1016/bs.mie.2024.11.017.

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Conference papers on the topic "TRNA-derived small RNAs"

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Kim, Hak Kyun, Jianpeng Xu, Kirk Chu, et al. "Abstract LB-343: A Leu(CAG)-tRNA derived small RNA regulates ribosomal protein S28 after translation initiation in both human and mouse liver cancers." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-lb-343.

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Li, Yuping, Xiwei Wu, Hanlin Gao, et al. "Abstract LB-247: 5′-tRFHis-GTG, a novel tRNA-derived novel miRNA-like small non-coding RNA, aberrantly expressed in metastatic renal cell carcinoma by promoting tumor cell proliferation, migration and invasion." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-lb-247.

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You might also be interested in the extended bibliographies on the topic 'TRNA-derived small RNAs' for particular source types:
Journal articles
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