Relevant bibliographies by topics / Trypanocidal activity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Trypanocidal activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Trypanocidal activity"

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Enanga, Bertin, Mark R. Ariyanayagam, Mhairi L. Stewart, and Michael P. Barrett. "Activity of Megazol, a Trypanocidal Nitroimidazole, Is Associated with DNA Damage." Antimicrobial Agents and Chemotherapy 47, no. 10 (2003): 3368–70. http://dx.doi.org/10.1128/aac.47.10.3368-3370.2003.

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ABSTRACT DNA damage associated with the trypanocidal activity of megazol [2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole] was shown in experiments in which DNA repair-deficient RAD51−/− Trypanosoma brucei mutants were found to be hypersensitive to the drug. Parasites resistant to megazol were selected and showed modest cross-resistance to other trypanocides, although neither drug efflux nor changes to intracellular thiols correlated with resistance.
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Awad, Mohamed K., Saida A. El-Enien, and Mohammed H. Rizk. "Quantitative Structure-Trypanocidal Activity Relationship Analysis of Phenothiazine Derivatives." Indian Journal of Applied Research 3, no. 9 (2011): 65–68. http://dx.doi.org/10.15373/2249555x/sept2013/20.

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Maciel Diogo, Gabriela, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, and Jason Guy Taylor. "Trypanocidal Activity of Flavanone Derivatives." Molecules 25, no. 2 (2020): 397. http://dx.doi.org/10.3390/molecules25020397.

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Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase. Furthermore, strong side effects may result in discontinuation of this treatment. Faced with this situation, we report the synthesis and trypanocidal activity of 3-benzoyl-flavanones. Novel 3-benzoyl-flavanone derivatives were prepared in satisfactory yields in the 3-step s
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Boda, Caroline, Bertin Enanga, Bertrand Courtioux, J. Christian Breton, and Bernard Bouteille. "Trypanocidal Activity of Methylene Blue." Chemotherapy 52, no. 1 (2005): 16–19. http://dx.doi.org/10.1159/000090236.

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da Silva Filho, Ademar A., Sérgio Albuquerque, Márcio L. A. e. Silva, Marcos N. Eberlin, Daniela M. Tomazela, and Jairo K. Bastos. "Tetrahydrofuran Lignans fromNectandramegapotamicawith Trypanocidal Activity⊥." Journal of Natural Products 67, no. 1 (2004): 42–45. http://dx.doi.org/10.1021/np0302697.

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Ward, Christopher P., Pui Ee Wong, Richard J. Burchmore, Harry P. de Koning, and Michael P. Barrett. "Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 2352–61. http://dx.doi.org/10.1128/aac.01551-10.

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ABSTRACTCurrent therapies for human African trypanosomiasis (HAT) are unsatisfactory and under threat from emerging drug resistance linked to the loss of transporters, e.g., the P2 aminopurine transporter (TbAT1). Here we compare the uptake and trypanocidal properties of furamidine (DB75), recently evaluated in clinical trials against stage 1 (haemolymphatic) HAT, and two aza analogues, DB820 and CPD0801 (DB829), which are candidate compounds for treatment of stage 2 (neurological) disease. Values of 50% inhibitory concentrations (IC50s) determinedin vitroagainst both wild-type and transporter
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Steverding, Dietmar, Stuart A. Rushworth, Georgina R. Hurle, et al. "Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment." Molecules 29, no. 23 (2024): 5597. http://dx.doi.org/10.3390/molecules29235597.

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Salinomycin and its derivatives display promising anti-proliferating activity against bloodstream forms of Trypanosoma brucei. The mechanism of trypanocidal action of these compounds is due to their ionophoretic activity inducing an influx of sodium cations followed by osmotic water uptake, leading to massive swelling of bloodstream-form trypanosomes. Generally, higher trypanocidal activities of salinomycin derivatives are associated with higher cell swelling activities. Although ironomycin (C20-propargylamine derivative of salinomycin) and salinomycin showed identical cell swelling activities
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Moncada-Basualto, Mauricio, Jorge Saavedra-Olavarría, Paula S. Rivero-Jerez, et al. "Assessment of the Activity of Nitroisoxazole Derivatives against Trypanosoma cruzi." Molecules 29, no. 12 (2024): 2762. http://dx.doi.org/10.3390/molecules29122762.

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The development of new compounds to treat Chagas disease is imperative due to the adverse effects of current drugs and their low efficacy in the chronic phase. This study aims to investigate nitroisoxazole derivatives that produce oxidative stress while modifying the compounds’ lipophilicity, affecting their ability to fight trypanosomes. The results indicate that these compounds are more effective against the epimastigote form of T. cruzi, with a 52 ± 4% trypanocidal effect for compound 9. However, they are less effective against the trypomastigote form, with a 15 ± 3% trypanocidal effect. Ad
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Ede, Samuel Otokpa, John Chinyere Aguiyi, Simeon Omale, and Rebecca Folashade Ede. "Anti-trypanosomal, antioxidant and antimicrobial activities of the fruiting bodies of Ganoderma lucidum (W. Curt.: Fr) (Ganodermataceae) aqueous extract." Journal of Pharmacy & Bioresources 18, no. 3 (2021): 172–81. http://dx.doi.org/10.4314/jpb.v18i3.1.

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Human African Trypanosomiasis (HAT) infection is caused by sub species of Trypanosoma brucei. The clinically licensed drugs have unacceptable toxicities and variable efficacies. The prognosis is influenced by the level of circulating free radicals and opportunistic infections. Many plants have been screened for activity in different models of HAT but the same is not true of mushrooms. This study screened the aqueous extract of the fruiting bodies of Ganoderma lucidum for trypanocidal, antioxidant and antimicrobial activities. Fruiting bodies of the mushroom were extracted sequentially with n –
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Steverding, Dietmar, Lázaro Gomes do Nascimento, Yunierkis Perez-Castillo, and Damião Pergentino de Sousa. "Gallic Acid Alkyl Esters: Trypanocidal and Leishmanicidal Activity, and Target Identification via Modeling Studies." Molecules 27, no. 18 (2022): 5876. http://dx.doi.org/10.3390/molecules27185876.

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Eight gallic acid alkyl esters (1–8) were synthesized via Fischer esterification and evaluated for their trypanocidal and leishmanicidal activity using bloodstream forms of Trypanosoma brucei and promastigotes of Leishmania major. The general cytotoxicity of the esters was evaluated with human HL-60 cells. The compounds displayed moderate to good trypanocidal but zero to low leishmanicidal activity. Gallic acid esters with alkyl chains of three or four carbon atoms in linear arrangement (propyl (4), butyl (5), and isopentyl (6)) were found to be the most trypanocidal compounds with 50% growth
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Dissertations / Theses on the topic "Trypanocidal activity"

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Oliveira, Fabr?cio de. "Triagem da atividade antitumoral e antimicrobiana de plantas nativas do cerrado da regi?o de Diamantina - Vale do Jequitinhonha/Minas Gerais." UFVJM, 2016. http://acervo.ufvjm.edu.br/jspui/handle/1/1104.

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Data de aprova??o ausente.<br>Disponibiliza??o do conte?do parcial, conforme Termo de Autoriza??o no trabalho.<br>Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2016-12-20T11:25:18Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) fabricio_oliveira_parcial.pdf: 460996 bytes, checksum: 830d7a19829ad0928872ba9504ea142a (MD5)<br>Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-01-10T12:15:20Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)
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Menzies, Stefanie Kate. "Investigating the trypanocidal activity of simplified natural product-like analogs and the characterization of a novel trypanosomatid-specific secondary alternative oxidase." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/12041.

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This thesis aimed to identify the trypanocidal mode of action of non-natural chamuvarinin analogs, and to assess the previously uncharacterized secondary alternative oxidase (AOX2) as a possible drug target of the trypanosomatids. The drugs used to treat infections with Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are highly toxic and are increasingly becoming less effective as the parasites develop resistance, therefore new drugs against the diseases are desperately needed. Non-natural analogs of chamuvarinin were tested for trypanocidal activity to determine the structure activi
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Carroccia, Murilo César. "Complexos de oxovanádio(V) com ligantes hidrazonas bioativos: síntese, caracterização estrutural e estudo da potencial atividade tripanocida." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-28082014-162915/.

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A doença de Chagas, também chamada de tripanossomíase americana é a terceira doença parasítica mais presente no mundo, perdendo apenas para malária e esquistossomose. As terapias existentes atualmente para essa tripanossomíase são insatisfatórias e pouca atenção tem sido dada para o desenvolvimento de novos fármacos. Os medicamentos utilizados atualmente apresentam boa atividade apenas na fase inicial da doença e geram efeitos colaterais severos nos pacientes. <br /> As hidrazonas representam uma classe de compostos imínicos de grande versatilidade estrutural e importante atividade biológica e
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Cunha, Let?cia Figueiredo. "Plantas do cerrado brasileiro: triagem fitoqu?mica e de atividades biol?gicas de esp?cies nativas do munic?pio de Diamantina, regi?o do Vale do Jequitinhonha, Minas Gerais." UFVJM, 2016. http://acervo.ufvjm.edu.br/jspui/handle/1/1433.

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?rea de concentra??o: Ci?ncias farmac?uticas.<br>Data de aprova??o ausente.<br>Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-08-01T18:51:24Z No. of bitstreams: 2 leticia_figueiredo_cunha.pdf: 6440587 bytes, checksum: 74ac0e7008e3cbee954ff6c0815803c4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-08-14T16:34:13Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) leticia_figueiredo_cunha.pdf: 64405
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Ferreira, Daniele da Silva. "Propriedades terapêuticas de triterpenos ácidos na doença de Chagas experimental - avaliação em fase aguda da infecção." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-01072010-134659/.

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A doença de Chagas é um problema de saúde pública, com dados preocupantes referentes ao número de pessoas contaminadas e daquelas que ainda permanecem expostas ao risco de infecção. As doenças tropicais desafiam as pesquisas científicas, pois os medicamentos existentes apresentam sérios efeitos colaterais. As tripanossomíases são doenças de grande importância no Brasil, como é o caso da doença de Chagas. Estudos realizados em diversos países têm relatado que muitas espécies vegetais possuem atividade contra o agente etiológico da doença de Chagas, Trypanosoma cruzi. Ácido ursólico e seu isômer
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Sabino, Gustavo Levendoski. "Investigação da reatividade de complexos metálicos com ligantes bases de Schiff frente a infecções parasitárias." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-21012015-085103/.

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Ligantes oxindolimínicos foram sintetizados através de procedimentos já desenvolvidos em nosso laboratório, a partir do 2,3-dioxindol (isatina) e aminas ou diaminas selecionadas, e em seguida metalados. Foram investigados dois complexos de cobre(II) com os ligantes isaepy, preparado a partir de 2-(2-aminoetilpiridina) e isapn, a partir de 1,2-diaminoetano, e os correspondentes complexos de zinco(II). Após caracterização por diversas técnicas, sua reatividade com relação a biomoléculas (HSA e DNA) foi verificada, através de medidas de fluorescência e dicroísmo circular. Posteriormente, sua reat
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Silva, Paulo Sérgio Siberti da [UNESP]. "Caracterização da diversidade genética e composição química de Lychnophora pinaster MART." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/139537.

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Submitted by PAULO SÉRGIO SIBERTI DA SILVA null (sibertisilva@hotmail.com) on 2016-06-23T02:50:14Z No. of bitstreams: 1 tese_definitiva_rev Marcia_final_22_06_2016.pdf: 7944179 bytes, checksum: c1b7190a1c23d0d924b3a8e4d60ff257 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-06-24T18:03:08Z (GMT) No. of bitstreams: 1 silva_pss_dr_bot.pdf: 7944179 bytes, checksum: c1b7190a1c23d0d924b3a8e4d60ff257 (MD5)<br>Made available in DSpace on 2016-06-24T18:03:08Z (GMT). No. of bitstreams: 1 silva_pss_dr_bot.pdf: 7944179 bytes, checksum: c1b7190a1c2
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Santos, Frances Regiane dos. "Estudo comparativo dos ?leos essenciais de esp?cies da fam?lia Myrtaceae atrav?s do perfil cromatogr?fico, an?lise multivariada e atividades biol?gicas." Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/1971.

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Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-08-18T11:50:39Z No. of bitstreams: 1 2016 - Frances Regiane dos Santos.pdf: 3889746 bytes, checksum: 193cd2f941ca3560b1dd12601120624e (MD5)<br>Made available in DSpace on 2017-08-18T11:50:39Z (GMT). No. of bitstreams: 1 2016 - Frances Regiane dos Santos.pdf: 3889746 bytes, checksum: 193cd2f941ca3560b1dd12601120624e (MD5) Previous issue date: 2016-09-19<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>The Myrtaceae family comprises more than 3,500 species, which are widely distributed on all continents (ex
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Bastos, Tanira Matutino. "Avalia??o da atividade anti-Trypanosoma cruzi de nitrosilo/nitro complexos de rut?nio em modelos experimentais in vitro e in vivo." Universidade Estadual de Feira de Santana, 2013. http://localhost:8080/tede/handle/tede/259.

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Submitted by Natalie Mendes (nataliermendes@gmail.com) on 2015-11-12T22:45:09Z No. of bitstreams: 1 Vers?o corrigida - vers?o final.pdf: 1423044 bytes, checksum: 6989a397b0d890ed1cb80eaaf86dcd52 (MD5)<br>Made available in DSpace on 2015-11-12T22:45:09Z (GMT). No. of bitstreams: 1 Vers?o corrigida - vers?o final.pdf: 1423044 bytes, checksum: 6989a397b0d890ed1cb80eaaf86dcd52 (MD5) Previous issue date: 2013-03-27<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>Nifurtimox and benznidazole have been used to treat Chagas? disease since the 70s. Both drugs can induce s
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Fernandez-Gomez, Rodolfo. "Trypanosoma cruzi : contribution à l'identification de substances chimiques et naturelles ayant une activité trypanocide." Lille 1, 1996. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1996/50376-1996-202.pdf.

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Notre travail de thèse a consisté à rechercher de nouvelles substances naturelles ou synthétiques ayant un effet trypanocide. Nous nous sommes tout d'abord intéressés à des substances actives contenues dans le venin de différents serpents (cerastes. Ceraste, naja haje et vipera lebetine). Par la suite, nous nous sommes focalisés sur le venin de C. Ceraste en raison de son innocuité. Notre étude in vitro, a montré une diminution significative de l'incorporation de thymidine tritiée par les formes épimastigotes, et de l'uridine tritiée par les formes trypomastigotes et amastigotes en présence de
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Book chapters on the topic "Trypanocidal activity"

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Sant’Ana, A. E. G., M. O. F. Goulart, A. F. Dos Santos, et al. "Molluscicidal and Trypanocidal Activity of Lapachol and Some Derivatives." In Natural Products in the New Millennium: Prospects and Industrial Application. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-015-9876-7_27.

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"Crude Extracts and Isolated Compounds with Trypanocidal Activity." In Antiprotozoal Drug Discovery: A Challenge That Remains, edited by Paz Salazar Schettino, Gloria Rojas, Margarita Cabrera, and Martha Bucio. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083292116010006.

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Pires, Fernanda Brum, Carolina Bolsoni Dolwitsch, Matheus Dellámea Baldissera, et al. "EVALUATION OF NEMATICIDE AND TRYPANOCIDAL ACTIVITY DIFFERENT EXTRACTS THE Ruellia angustiflora." In Farmácia na Atenção e Assistência à Saúde 2. Atena Editora, 2020. http://dx.doi.org/10.22533/at.ed.7372015128.

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de Souza, Anacleto S., Leonardo G. Ferreira, and Adriano D. Andricopulo. "2D and 3D QSAR Studies on a Series of Antichagasic Fenarimol Derivatives." In Pharmaceutical Sciences. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1762-7.ch037.

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Chagas disease is one of the most important neglected tropical diseases. Endemic in Latin America, the disease is a global public health problem, affecting several countries in North America, Europe, Asia and Oceania. The disease affects around 8-10 million people worldwide and the limited treatments available present low efficacy and severe side effects, highlighting the urgent need for new therapeutic options. In this work, the authors developed QSAR models for a series of fenarimol derivatives exhibiting anti-T. cruzi activity. The models were constructed using the Hologram QSAR (HQSAR), Co
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Reséndiz-Mora, Albany, Juan Carlos Santiago-Hernández, Juan Manuel Serna-Velázquez, et al. "Development of Novel Drugs for the Treatment of Chagas Disease." In Current Topics in Zoonoses [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.112548.

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Chagas disease, or American trypanosomiasis, is a zoonosis caused by the hemoflagellate parasite Trypanosoma cruzi. It is mainly transmitted by the bite of blood-sucking insects. It is endemic in Latin America and emerging in the rest of the world, affecting approximately six million people. The drugs Benznidazole and Nifurtimox currently used for its treatment are not totally effective in the chronic phase of the disease. In addition, they are toxic, and there are many resistant Trigonoscuta cruzi strains. Therefore, developing new drugs for the treatment of Chagas disease is necessary. This
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"CHAGAS DISEASE An Overview of Recent Advances in the Search for Synthetic Organic Compounds with Trypanocidal Activity." In Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases, edited by Ana Camila Micheletti, Edson dos Santos, and Felicia Megumi Ito. BENTHAM SCIENCE PUBLISHERS, 2014. http://dx.doi.org/10.2174/9781608059027114010004.

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Shaba, P., N. N. Pandey, O. P. Sharma, et al. "Investigating the Trypanocidal Activity of Purified Precocene I by Reverse-Phase High-Performance Liquid Chromatography from Essential Oil of Ageratum houstonianum Aerial Parts." In Technological Innovation in Pharmaceutical Research Vol. 10. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/tipr/v10/7218d-3.

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Conference papers on the topic "Trypanocidal activity"

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Cardoso, Mariana F. do Carmo, David R. da Rocha, Kelly Salomão, Solange de Castro, Fernando de C. da Silva та Vitor F. Ferreira. "Synthesis of 3-triazole-nor-β-lapachones with potential trypanocidal activity". У 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201395133536.

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