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Dissertations / Theses on the topic 'Trypanocidal activity'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Oliveira, Fabr?cio de. "Triagem da atividade antitumoral e antimicrobiana de plantas nativas do cerrado da regi?o de Diamantina - Vale do Jequitinhonha/Minas Gerais." UFVJM, 2016. http://acervo.ufvjm.edu.br/jspui/handle/1/1104.

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Data de aprova??o ausente.<br>Disponibiliza??o do conte?do parcial, conforme Termo de Autoriza??o no trabalho.<br>Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2016-12-20T11:25:18Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) fabricio_oliveira_parcial.pdf: 460996 bytes, checksum: 830d7a19829ad0928872ba9504ea142a (MD5)<br>Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-01-10T12:15:20Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)
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2

Menzies, Stefanie Kate. "Investigating the trypanocidal activity of simplified natural product-like analogs and the characterization of a novel trypanosomatid-specific secondary alternative oxidase." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/12041.

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This thesis aimed to identify the trypanocidal mode of action of non-natural chamuvarinin analogs, and to assess the previously uncharacterized secondary alternative oxidase (AOX2) as a possible drug target of the trypanosomatids. The drugs used to treat infections with Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are highly toxic and are increasingly becoming less effective as the parasites develop resistance, therefore new drugs against the diseases are desperately needed. Non-natural analogs of chamuvarinin were tested for trypanocidal activity to determine the structure activi
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3

Carroccia, Murilo César. "Complexos de oxovanádio(V) com ligantes hidrazonas bioativos: síntese, caracterização estrutural e estudo da potencial atividade tripanocida." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-28082014-162915/.

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A doença de Chagas, também chamada de tripanossomíase americana é a terceira doença parasítica mais presente no mundo, perdendo apenas para malária e esquistossomose. As terapias existentes atualmente para essa tripanossomíase são insatisfatórias e pouca atenção tem sido dada para o desenvolvimento de novos fármacos. Os medicamentos utilizados atualmente apresentam boa atividade apenas na fase inicial da doença e geram efeitos colaterais severos nos pacientes. <br /> As hidrazonas representam uma classe de compostos imínicos de grande versatilidade estrutural e importante atividade biológica e
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4

Cunha, Let?cia Figueiredo. "Plantas do cerrado brasileiro: triagem fitoqu?mica e de atividades biol?gicas de esp?cies nativas do munic?pio de Diamantina, regi?o do Vale do Jequitinhonha, Minas Gerais." UFVJM, 2016. http://acervo.ufvjm.edu.br/jspui/handle/1/1433.

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?rea de concentra??o: Ci?ncias farmac?uticas.<br>Data de aprova??o ausente.<br>Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-08-01T18:51:24Z No. of bitstreams: 2 leticia_figueiredo_cunha.pdf: 6440587 bytes, checksum: 74ac0e7008e3cbee954ff6c0815803c4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-08-14T16:34:13Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) leticia_figueiredo_cunha.pdf: 64405
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5

Ferreira, Daniele da Silva. "Propriedades terapêuticas de triterpenos ácidos na doença de Chagas experimental - avaliação em fase aguda da infecção." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-01072010-134659/.

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A doença de Chagas é um problema de saúde pública, com dados preocupantes referentes ao número de pessoas contaminadas e daquelas que ainda permanecem expostas ao risco de infecção. As doenças tropicais desafiam as pesquisas científicas, pois os medicamentos existentes apresentam sérios efeitos colaterais. As tripanossomíases são doenças de grande importância no Brasil, como é o caso da doença de Chagas. Estudos realizados em diversos países têm relatado que muitas espécies vegetais possuem atividade contra o agente etiológico da doença de Chagas, Trypanosoma cruzi. Ácido ursólico e seu isômer
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6

Sabino, Gustavo Levendoski. "Investigação da reatividade de complexos metálicos com ligantes bases de Schiff frente a infecções parasitárias." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-21012015-085103/.

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Ligantes oxindolimínicos foram sintetizados através de procedimentos já desenvolvidos em nosso laboratório, a partir do 2,3-dioxindol (isatina) e aminas ou diaminas selecionadas, e em seguida metalados. Foram investigados dois complexos de cobre(II) com os ligantes isaepy, preparado a partir de 2-(2-aminoetilpiridina) e isapn, a partir de 1,2-diaminoetano, e os correspondentes complexos de zinco(II). Após caracterização por diversas técnicas, sua reatividade com relação a biomoléculas (HSA e DNA) foi verificada, através de medidas de fluorescência e dicroísmo circular. Posteriormente, sua reat
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7

Silva, Paulo Sérgio Siberti da [UNESP]. "Caracterização da diversidade genética e composição química de Lychnophora pinaster MART." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/139537.

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Submitted by PAULO SÉRGIO SIBERTI DA SILVA null (sibertisilva@hotmail.com) on 2016-06-23T02:50:14Z No. of bitstreams: 1 tese_definitiva_rev Marcia_final_22_06_2016.pdf: 7944179 bytes, checksum: c1b7190a1c23d0d924b3a8e4d60ff257 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-06-24T18:03:08Z (GMT) No. of bitstreams: 1 silva_pss_dr_bot.pdf: 7944179 bytes, checksum: c1b7190a1c23d0d924b3a8e4d60ff257 (MD5)<br>Made available in DSpace on 2016-06-24T18:03:08Z (GMT). No. of bitstreams: 1 silva_pss_dr_bot.pdf: 7944179 bytes, checksum: c1b7190a1c2
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8

Santos, Frances Regiane dos. "Estudo comparativo dos ?leos essenciais de esp?cies da fam?lia Myrtaceae atrav?s do perfil cromatogr?fico, an?lise multivariada e atividades biol?gicas." Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/1971.

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Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-08-18T11:50:39Z No. of bitstreams: 1 2016 - Frances Regiane dos Santos.pdf: 3889746 bytes, checksum: 193cd2f941ca3560b1dd12601120624e (MD5)<br>Made available in DSpace on 2017-08-18T11:50:39Z (GMT). No. of bitstreams: 1 2016 - Frances Regiane dos Santos.pdf: 3889746 bytes, checksum: 193cd2f941ca3560b1dd12601120624e (MD5) Previous issue date: 2016-09-19<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>The Myrtaceae family comprises more than 3,500 species, which are widely distributed on all continents (ex
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9

Bastos, Tanira Matutino. "Avalia??o da atividade anti-Trypanosoma cruzi de nitrosilo/nitro complexos de rut?nio em modelos experimentais in vitro e in vivo." Universidade Estadual de Feira de Santana, 2013. http://localhost:8080/tede/handle/tede/259.

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Submitted by Natalie Mendes (nataliermendes@gmail.com) on 2015-11-12T22:45:09Z No. of bitstreams: 1 Vers?o corrigida - vers?o final.pdf: 1423044 bytes, checksum: 6989a397b0d890ed1cb80eaaf86dcd52 (MD5)<br>Made available in DSpace on 2015-11-12T22:45:09Z (GMT). No. of bitstreams: 1 Vers?o corrigida - vers?o final.pdf: 1423044 bytes, checksum: 6989a397b0d890ed1cb80eaaf86dcd52 (MD5) Previous issue date: 2013-03-27<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>Nifurtimox and benznidazole have been used to treat Chagas? disease since the 70s. Both drugs can induce s
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10

Fernandez-Gomez, Rodolfo. "Trypanosoma cruzi : contribution à l'identification de substances chimiques et naturelles ayant une activité trypanocide." Lille 1, 1996. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1996/50376-1996-202.pdf.

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Notre travail de thèse a consisté à rechercher de nouvelles substances naturelles ou synthétiques ayant un effet trypanocide. Nous nous sommes tout d'abord intéressés à des substances actives contenues dans le venin de différents serpents (cerastes. Ceraste, naja haje et vipera lebetine). Par la suite, nous nous sommes focalisés sur le venin de C. Ceraste en raison de son innocuité. Notre étude in vitro, a montré une diminution significative de l'incorporation de thymidine tritiée par les formes épimastigotes, et de l'uridine tritiée par les formes trypomastigotes et amastigotes en présence de
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11

Trabelsi, Mohamed. "Synthèse d'une nouvelle série de spiroarsoranes à ligands catécholamide. Activités antifilarienne et trypanocide." Toulouse 3, 1992. http://www.theses.fr/1992TOU30113.

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Les travaux qui font l'objet de cette these sont consacres a la mise au point d'une nouvelle serie de spiroarsoranes a ligands catecholamide, inclus ou non dans des structures macrocycliques. La presence d'une fonction amide et d'une molecule d'eau dans ces structures leur confere des caracteristiques physicochimiques particulieres. Une etude en resonance magnetique nucleaire dynamique de ces composes pentacoordines a permis la mise en evidence d'une labilite structurale qui se traduit par la mise en jeu de plusieurs formes en equilibre. Ceci est lie a l'intervention de plusieurs phenomenes do
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12

Okpekon, Timothée Aboua. "Etude chimique et biologique de plantes ivoiriennes utilisées en médecine traditionelle en tant qu'antiparasitaires : Aframomum sceptrum K. Schum. (Zingiberaceae), Bridelia Ferruginea Benth. (Euphorbiaceae), Isolona cooperi Hutch. & Dalz. et Uvaria afzelii Sc. Elliot (Annonaceae)." Paris 11, 2006. http://www.theses.fr/2006PA114822.

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La trypanosomiase humaine africaine (THA) ou maladie du sommeil continue de sévir en Côte d’Ivoire. Une étude ethnopharmacologique de terrain réalisée dans les zones de forte incidence de la maladie a conduit au recensement de 34 plantes parmi lesquelles 18, non répertoriées, ont fait l’objet d’un criblage biologique in vitro, en utilisant comme modèles Trypanosoma brucei brucei et Leishmania donavani. Suite à ce criblage, quatre drogues ont été sélectionnées pour une étude chimique en raison de leur fort potentiel sur les parasites : les rhizomes d’Aframomum sceptrum K. Schum. (Zingiberaceae)
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13

Betbeder, Didier. "Synthese et etude du mode d'action d'inhibiteurs de voies metaboliques du trypanosome." Toulouse 3, 1988. http://www.theses.fr/1988TOU30029.

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Etude d'inhibiteurs de voies metaboliques du trypanosome. Synthese et action d'inhibiteurs possibles d'enzymes de replication. Etude d'enzymes de la glycolyse, cible cle dans le trypanosome, celui-ci utilisant le glucose comme seule source d'energie. Puis caracterisation d'une proteine qui presente les proprietes de recepteur vis-a-vis d'une nouvelle famille de trypanocides derives du diphenyl methane
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14

Sola, I., S. Castellà, E. Viayna, et al. "Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity." 2015. http://hdl.handle.net/10454/7485.

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Yes<br>Dual submicromolar trypanocidal–antiplasmodial compounds have been identified by screening and chemical synthesis of 4-aminoquinoline-based heterodimeric compounds of three different structural classes. In Trypanosoma brucei, inhibition of the enzyme trypanothione reductase seems to be involved in the potent trypanocidal activity of these heterodimers, although it is probably not the main biological target. Regarding antiplasmodial activity, the heterodimers seem to share the mode of action of the antimalarial drug chloroquine, which involves inhibition of the haem detoxification proces
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15

Sola, I., A. Artigas, M. C. Taylor, et al. "Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines." 2014. http://hdl.handle.net/10454/7496.

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We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability. Most dimers have more potent and selective trypanocidal activity than huprine Y and are brain permeable, but they are devoid of antimalarial activity and remain active against hAChE. Lead optimization will focus on identifying compounds with a more favourable trypanocidal/anticholinesterase activity ratio.
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16

Gordon, Allen Tauya. "Synthetic studies and biological evaluation of chromone - 3 - carbaldehydes." Diss., 2018. http://hdl.handle.net/11602/1214.

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MSc (Chemistry)<br>Department of Chemistry<br>Chromones are well known naturally occurring heterocyclic compounds with oxygen as a heteroatom. Chromones are also one of the major classes of naturally occurring compounds, and the interest in their chemistry is due to their wide range of their biological activity. In this study, three classes of target compounds were synthesized through three different pathways. The first pathway, chromone-3-carbaldehyde analogues were afforded in good to excellent yield followed by the oxidation thereof to 4-oxo-4H-chromene-3-carboxylic acids. A series of chro
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