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Relevant bibliographies by topics / Trypanosoma brucei. African trypanosomiasis

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Academic literature on the topic 'Trypanosoma brucei. African trypanosomiasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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Journal articles on the topic "Trypanosoma brucei. African trypanosomiasis"

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Magez, Stefan, Joar Esteban Pinto Torres, Seoyeon Oh, and Magdalena Radwanska. "Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System." Pathogens 10, no. 6 (2021): 679. http://dx.doi.org/10.3390/pathogens10060679.

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Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T. brucei causing human African trypanosomiasis (HAT—sleeping sickness). The related T. b. brucei parasite lacks the resistance to survive in human serum, and only inflicts animal infections. Animal trypanosomiasis (AT) is not restricted to Africa, but is present on all continents. T. congolense and T. vivax are the most widespread pathogenic trypanosomes in sub-Saharan Africa. Through mechanical tra

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Kubata, Bruno Kilunga, Michael Duszenko, Zakayi Kabututu та ін. "Identification of a Novel Prostaglandin F2α Synthase in Trypanosoma brucei". Journal of Experimental Medicine 192, № 9 (2000): 1327–38. http://dx.doi.org/10.1084/jem.192.9.1327.

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Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. Infection of mammals by African trypanosomes is characterized by an upregulation of prostaglandin (PG) production in the plasma and cerebrospinal fluid. These metabolites of arachidonic acid (AA) may, in part, be responsible for symptoms such as fever, headache, immunosuppression, deep muscle hyperaesthesia, miscarriage, ovarian dysfunction, sleepiness, and other symptoms observed in patients with chronic African trypanosomiasis. Here, we show that the protozoan parasite T. brucei is involved in PG

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Katabazi, Aziz, Adamu Almustapha Aliero, Sarah Gift Witto, Martin Odoki, and Simon Peter Musinguzi. "Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda." BioMed Research International 2021 (June 14, 2021): 1–7. http://dx.doi.org/10.1155/2021/7284042.

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Trypanosomes are the causative agents of animal African trypanosomiasis (AAT) and human African trypanosomiasis (HAT), the former affecting domestic animals prevalent in Sub-Saharan Africa. The main species causing AAT in cattle are T. congolense, T. vivax, and T. b. brucei. Northern Uganda has been politically unstable with no form of vector control in place. The return of displaced inhabitants led to the restocking of cattle from AAT endemic areas. It was thus important to estimate the burden of trypanosomiasis in the region. This study was designed to compare the prevalence of animal Africa

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Pereira, Glaécia AN, Lucianna H. Santos, Steven C. Wang, et al. "Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei." Future Medicinal Chemistry 11, no. 13 (2019): 1537–51. http://dx.doi.org/10.4155/fmc-2018-0523.

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Aim: Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets for treatment of Chagas disease and human African trypanosomiasis. Previous studies reported a benzimidazole series as potent cruzain inhibitors. Results & methodology: Considering the high similarity between these proteases, we evaluated 40 benzimidazoles against rhodesain. We describe their structure-activity relationships (SAR), revealing trends similar to those observed for cruzain and features that lead to enzyme selectivi

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Nayupe, Symon F. "The use of molecular technology to investigate trypanosome infections in tsetse flies at Liwonde Wild Life Reserve." Malawi Medical Journal 31, no. 4 (2020): 233–37. http://dx.doi.org/10.4314/mmj.v31i4.3.

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BackgroundTrypanosomes are protozoan flagellates that cause human African trypanosomiasis (HAT) and African animal trypanosomiasis (AAT). HAT is caused by Trypanosoma brucei rhodesiense in East and Central Africa and T.b. gambiense in West Africa, whereas AAT is caused by a number of trypanosome species, including T. brucei brucei, T. evansi, T. vivax, T. congolense, T. godfreyi and T. simiae. The aim of this study was to establish if tsetse flies at Liwonde Wild Life Reserve (LWLR) are infected with these trypanosomes and thus pose a risk to both humans and animals within and surrounding the

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Morty, Rory E., Patrick Bulau, Roger Pellé, Sherwin Wilk, and Koji Abe. "Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts." Biochemical Journal 394, no. 3 (2006): 635–45. http://dx.doi.org/10.1042/bj20051593.

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Peptidases of parasitic protozoans are emerging as novel virulence factors and therapeutic targets in parasitic infections. A trypanosome-derived aminopeptidase that exclusively hydrolysed substrates with Glp (pyroglutamic acid) in P1 was purified 9248-fold from the plasma of rats infected with Trypanosoma brucei brucei. The enzyme responsible was cloned from a T. brucei brucei genomic DNA library and identified as type I PGP (pyroglutamyl peptidase), belonging to the C15 family of cysteine peptidases. We showed that PGP is expressed in all life cycle stages of T. brucei brucei and is expresse

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Rao, Srinivasa P. S., Suresh B. Lakshminarayana, Jan Jiricek, et al. "Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis." Tropical Medicine and Infectious Disease 5, no. 1 (2020): 28. http://dx.doi.org/10.3390/tropicalmed5010028.

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Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the triazolopyrimidine (TP) class as selective kinetoplastid proteasome inhibitors with in vivo efficacy in mouse models of leishmaniasis, Chagas Disease and African trypanosomiasis (HAT). For the treatment of HAT, development compounds need to have excellent penetration to the brain to cure the meningoencephalic stage of the disease. Here we describe deta

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Dai, Jennifer. "Resolving Trypanosoma brucei Flagellar Structure by Cryo-Electron Tomography." E3S Web of Conferences 131 (2019): 01012. http://dx.doi.org/10.1051/e3sconf/201913101012.

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Trypanosoma brucei is a unicellular eukaryote that can cause human African trypanosomiasis, which has continued to evolve and spread. The key feature of these parasites is that they have a flagellum consists of a typical 9 + 2 axoneme and a lattice-like paraflagellar rod (PFR). It attached to the cell body and is responsible for cell motility, cytokinesis, and morphogenesis. The present study demonstrates the detailed structure and defines the length of the axoneme and three domains of the paraflagellar rod (PFR) using cryo-electron tomography of Trypanosoma brucei flagella. The performed anal

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Truc, P., and M. Tibayrenc. "Population genetics of Trypanosoma brucei in Central Africa: taxonomic and epidemiological significance." Parasitology 106, no. 2 (1993): 137–49. http://dx.doi.org/10.1017/s003118200007493x.

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SUMMARYIn order to estimate the value of population genetics for both the taxonomy of trypanosomes belonging to the species Trypanosoma brucei and a better understanding of Human African Trypanosomiasis (HAT), we undertook a cellulose acetate electrophoresis isoenzyme study involving 55 stocks isolated from man and animals in Congo, Zaire and Cameroun. Out of the 24 loci surveyed, 15 exhibited variability, which made it possible to delimit 23 zymodemes, divided into 2 groups. The first group equated to the classical subspecies Trypanosoma brucei gambiense, while the second corresponded to the

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Carrington, Mark. "Slippery customers: How African trypanosomes evade mammalian defences." Biochemist 31, no. 4 (2009): 8–11. http://dx.doi.org/10.1042/bio03104008.

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African trypanosomes are excellent parasites and can maintain an infection of a large mammalian host for months or years. In endemic areas, Human African Trypanosomiasis, also called sleeping sickness, has been largely unaffected by the advent of modern medicine, and trypanosomiasis of domestic livestock is a major restraint on productivity in endemic areas and is arguably the major contributor to the institutionalized poverty in much of rural sub-Saharan Africa1,2. A simple way of visualizing the effect of the livestock disease is to compare maps showing the distribution of livestock (www.ilr

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Dissertations / Theses on the topic "Trypanosoma brucei. African trypanosomiasis"

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Millar, Amanda E. "T-cell responses during Trypanosoma brucei infections." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363151.

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Hickey, Meghan C. "Exploring an unusual beta-hydroxybutyrate dehydrogenase from Trypanosoma brucei." Click here for download, 2010. http://proquest.umi.com.ps2.villanova.edu/pqdweb?did=2011158651&sid=1&Fmt=7&clientId=3260&RQT=309&VName=PQD.

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Mabbott, Neil A. "Nitric oxide : host-protective or host-destructive during African trypanosomiasis." Thesis, University of Aberdeen, 1995. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU543723.

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The aims of the research presented in this thesis were concerned with investigating the effect of inducible nitric oxide (NO) synthase expression during Trypanosoma brucei infections on both host and parasite. NO was shown to exhibit a potent cytostatic effect on parasite proliferation. Oxyhaemoglobin is a potent scavenger of NO. The cytostatic effects of NO on the trypanosomes were completely prevented through the addition of erythrocytes to the cultures. This implies that in the host blood-stream, NO is unlikely to be involved in the eradication of the parasites. Through the adoptive transfe

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Jamnadass, Harmanjeet Ramni. "Identification and characterisation of an extrachromosomal element from a multidrug-resistant isolate of Trypanosoma brucei brucei." Thesis, Brunel University, 1995. http://bura.brunel.ac.uk/handle/2438/4314.

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Drug resistance together with difficulties involved in the development of new trypanocides are a major problem in the present control of African trypanosomiasis. DNA based diagnostics for drug resistance would overcome problems in the identification of drug-resistant populations and contribute to effective control measures. However, this requires a detailed knowledge of the mode of action and the mechanisms by which trypanosomes can overcome the toxic effects of trypanocides. In this study, a search for molecular differences between a multidrug-resistant isolate of Trypanosoma brucei brucei, C

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Giles, Natalie Lydia. "Exploitation of the protein tubulin for controlling African trypanosomiasis /." Access via Murdoch University Digital Theses Project, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060315.191003.

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Kinzel, Kathryn Whitney. "Functional analysis of inner-arm dynein knockdowns in Trypanosoma brucei /." Connect to online version, 2008. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2008/268.pdf.

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Hamadien, Maha. "Parasite signalling and host responses in experimental and human African trypanosomiasis /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-266-3.

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Felu, Cécile. "Characterisation of the mechanism of human serum resistance in T.b.gambiense." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210844.

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The two human pathogenic sub-species T.b.gambiense and T.b.rhodesiense can be distinguished from the morphologically identical T.b.brucei by their ability to infect humans, enabling them to cause sleeping sickness. This is because they are resistant to lysis by the lytic factor (APOL-I) present in normal human serum (NHS). In T.b.rhodesiense resistance to this lytic factor is due to a truncated VSG gene termed SRA which blocks lysis by interacting with APOL-I in the lysosome. SRA does not exist in T.b.gambiense. The search for a similar truncated VSG gene lead to the identification of a T.b.ga

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Kushwaha, Manish. "TbISWI and its role in transcriptional control in Trypanosoma brucei." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:36aedf26-7bbc-4f29-9fa5-fc57c9477c23.

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ISWI is a member of a versatile family of ATP-dependent chromatin remodelling complexes involved not only in transcription regulation (initiation, elongation and termination), but also in other cellular functions like maintenance of higher order chromatin structure and DNA replication. TbISWI, a novel ATPase of the ISWI family in Trypanosoma brucei, is involved in the transcriptional repression of silent VSG expression sites (ESs) in both bloodstream form (BF) and procyclic form (PF) life cycle stages of the parasite. Using in silico analysis, I have found that TbISWI is well conserved across

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Lilley, Alison. "An investigation into the Trypanosoma brucei CDP-DAG synthase and downstream pathways." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/3615.

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Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host, allowing a plethora of novel drug targets to be discovered and validated. Cytidine diphosphate diacylglycerol (CDP-DAG) is a central lipid intermediate produced by the enzyme CDP-DAG synthase (CDS), but nothing was known about CDS in T. brucei. Only one gene encodes CDS in Trypanosoma brucei (Tb927.7.220) and this was shown to encode a functional CDS by overexpression in E. coli and complementation of a yeast CDS null, which was created during this study. Expression and activi

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Books on the topic "Trypanosoma brucei. African trypanosomiasis"

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Magez, Stefan, and Magdalena Radwanska. Trypanosomes and Trypanosomiasis. Springer, 2013.

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Sakhuja, Vinay, and Harbir Singh Kohli. Leishmaniasis and trypanosomiasis. Edited by Vivekanand Jha. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0184_update_001.

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Visceral leishmaniasis, also known as kala-azar, has an insidious onset with constitutional features. Subsequently the intense parasitism of the reticuloendothelial system causes hepatosplenomegaly, anaemia, leucopenia, and thrombocytopaenia as well as hypergammaglobulinaemia. Kidney involvement manifests with proteinuria up to 1 g/24 hours, micro/macrohaematuria, and leucocyturia. Kidney involvement is generally mild and reversible with the treatment of infection. Biopsy appearances of diffuse proliferative glomerulonephritis, mesangial proliferation, and occasionally focal necrotizing glomer

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G, Hide, ed. Trypanosomiasis and leishmaniasis: Biology and control. CAB International, 1997.

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1934-, Dumas Michel, Bouteille Bernard 1952-, and Buguet Alain, eds. Progress in human African trypanosomiasis, sleeping sickness. Springer, 1999.

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Book chapters on the topic "Trypanosoma brucei. African trypanosomiasis"

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Gries, Oliver, and Thomas Ly. "Trypanosoma brucei: Afrikanische Trypanosomiasis, „Schlafkrankheit”." In Infektologie - Kompendium humanpathogener Infektionskrankheiten und Erreger. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-58219-0_63.

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Leung, Ka Fai, Paul T. Manna, Cordula Boehm, Luke Maishman, and Mark C. Field. "Cell Biology for Immune Evasion: Organizing Antigenic Variation, Surfaces, Trafficking, and Cellular Structures in Trypanosoma brucei." In Trypanosomes and Trypanosomiasis. Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1556-5_1.

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Despommier, Dickson D., Robert W. Gwadz, and Peter J. Hotez. "African Trypanosomes: Trypanosoma brucei gambiense (Dutton 1902) and Trypanosoma brucei rhodesiense (Stephens and Fantham 1910)." In Parasitic Diseases. Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4612-2476-1_31.

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Brun, Reto, and Johannes Blum. "Human African trypanosomiasis." In Oxford Textbook of Medicine, edited by Christopher P. Conlon. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0169.

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Human African trypanosomiasis (sleeping sickness) is caused by subspecies of the protozoan parasite Trypanosoma brucei. The disease is restricted to tropical Africa where it is transmitted by the bite of infected tsetse flies (Glossina spp.). Control programmes in the 1960s were very effective, but subsequent relaxation of control measures led to recurrence of epidemic proportions in the 1980s and 1990s. Control is now being regained. Untreated human African trypanosomiasis is almost invariably fatal. Specific treatment depends on the trypanosome subspecies and the stage of the disease. Drugs used for stage 1 include pentamidine and suramin, and for stage 2 include melarsoprol, eflornithine, and nifurtimox, but regimens are not standardized, and treatment is difficult and dangerous; all of the drugs used have many side effects, some potentially lethal.

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Stich, August. "Human African trypanosomiasis." In Oxford Textbook of Medicine. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.070810_update_001.

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Human African trypanosomiasis (HAT, sleeping sickness) is caused by two subspecies of the protozoan parasite Trypanosoma brucei: T. b. rhodesiense is prevalent in East Africa among many wild and domestic mammals; T. b. gambiense causes an anthroponosis in Central and West Africa. The disease is restricted to tropical Africa where it is transmitted by the bite of infected tsetse flies (...

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Salvana, Edsel Maurice T., and Robert A. Salata. "African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei Complex)." In Nelson Textbook of Pediatrics. Elsevier, 2011. http://dx.doi.org/10.1016/b978-1-4377-0755-7.00278-5.

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Kimaro, Esther Gwae, and Popoola Moshood Abiola. "Epidemiology and Economic Importance of African Animal Trypanosomiasis." In Advances in Environmental Engineering and Green Technologies. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-6433-2.ch002.

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African animal trypanosomiasis (AAT), also called Nagana, is a vector-borne parasitic disease caused by an extracellular protozoan belonging to the genus Trypanosoma. It has serious effects on the health status and welfare of domestic mammals which considerably results in a reduction in their productivity. In this review, a comprehensive overview of the epidemiology of AAT was provided with a special focus on its general clinical aspects (the clinical signs and pathogenesis as well as its transmission cycle), the parasite (Trypanosoma spp.), the parasite life cycle and transmission, its vector (Glossina spp.), tsetse fly lifecycle and reproduction, risk factors of AAT, and economic importance of AAT in the affected countries. The present work gave a detailed account of epidemiology in the context of infestation patterns, the parasite causing it, its vector, and the economic impacts of the disease on different livestock species.

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