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Journal articles on the topic 'Tryptophan operon repressor (TrpR)'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Akers, Johnny C., and Ming Tan. "Molecular Mechanism of Tryptophan-Dependent Transcriptional Regulation in Chlamydia trachomatis." Journal of Bacteriology 188, no. 12 (2006): 4236–43. http://dx.doi.org/10.1128/jb.01660-05.

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ABSTRACT Tryptophan is an essential amino acid that is required for normal development in Chlamydia species, and tryptophan metabolism has been implicated in chlamydial persistence and tissue tropism. The ability to synthesize tryptophan is not universal among the Chlamydiaceae, but species that have a predicted tryptophan biosynthetic pathway also encode an ortholog of TrpR, a regulator of tryptophan metabolism in many gram-negative bacteria. We show that in Chlamydia trachomatis serovar D, TrpR regulates its own gene and trpB and trpA, the genes for the two subunits of tryptophan synthase. T

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2

Sherchand, Shardulendra P., and Ashok Aiyar. "Ammonia generation by tryptophan synthase drives a key genetic difference between genital and ocular Chlamydia trachomatis isolates." Proceedings of the National Academy of Sciences 116, no. 25 (2019): 12468–77. http://dx.doi.org/10.1073/pnas.1821652116.

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A striking difference between genital and ocular clinical isolates of Chlamydia trachomatis is that only the former express a functional tryptophan synthase and therefore can synthesize tryptophan by indole salvage. Ocular isolates uniformly cannot use indole due to inactivating mutations within tryptophan synthase, indicating a selection against maintaining this enzyme in the ocular environment. Here, we demonstrate that this selection occurs in two steps. First, specific indole derivatives, produced by the human gut microbiome and present in serum, rapidly induce expression of C. trachomatis

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3

Brune, Iris, Nina Jochmann, Karina Brinkrolf, et al. "The IclR-Type Transcriptional Repressor LtbR Regulates the Expression of Leucine and Tryptophan Biosynthesis Genes in the Amino Acid Producer Corynebacterium glutamicum." Journal of Bacteriology 189, no. 7 (2007): 2720–33. http://dx.doi.org/10.1128/jb.01876-06.

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ABSTRACT The transcriptional regulator Cg1486 of Corynebacterium glutamicum ATCC 13032 is a member of the IclR protein family and belongs to the conserved set of regulatory proteins in corynebacteria. A defined deletion in the cg1486 gene, now designated ltbR (leucine and tryptophan biosynthesis regulator), led to the mutant strain C. glutamicum IB1486. According to whole-genome expression analysis by DNA microarray hybridizations, transcription of the leuB and leuCD genes encoding enzymes of the leucine biosynthesis pathway was enhanced in C. glutamicum IB1486 compared with the wild-type stra

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4

Xie, Yunwei, and John N. Reeve. "Regulation of Tryptophan Operon Expression in the Archaeon Methanothermobacter thermautotrophicus." Journal of Bacteriology 187, no. 18 (2005): 6419–29. http://dx.doi.org/10.1128/jb.187.18.6419-6429.2005.

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ABSTRACT Conserved trp genes encode enzymes that catalyze tryptophan biosynthesis in all three biological domains, and studies of their expression in Bacteria and eukaryotes have revealed a variety of different regulatory mechanisms. The results reported here provide the first detailed description of an archaeal trp gene regulatory system. We have established that the trpEGCFBAD operon in Methanothermobacter thermautotrophicus is transcribed divergently from a gene (designated trpY) that encodes a tryptophan-sensitive transcription regulator. TrpY binds to TRP box sequences (consensus, TGTACA)

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5

Sprenger, Janina, Catherine L. Lawson, Claes von Wachenfeldt, Leila Lo Leggio, and Jannette Carey. "Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan." Acta Crystallographica Section F Structural Biology Communications 77, no. 7 (2021): 215–25. http://dx.doi.org/10.1107/s2053230x21006142.

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The crystal structures of domain-swapped tryptophan repressor (TrpR) variant Val58Ile before and after soaking with the physiological ligand L-tryptophan (L-Trp) indicate that L-Trp occupies the same location in the domain-swapped form as in native dimeric TrpR and makes equivalent residue contacts. This result is unexpected because the ligand binding-site residues arise from three separate polypeptide chains in the domain-swapped form. This work represents the first published structure of a domain-swapped form of TrpR with L-Trp bound. The presented structures also show that the protein amino

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6

Su, Panpan, Zhiwei Song, Guichun Wu, et al. "Insights Into the Roles of Two Genes of the Histidine Biosynthesis Operon in Pathogenicity of Xanthomonas oryzae pv. oryzicola." Phytopathology® 108, no. 5 (2018): 542–51. http://dx.doi.org/10.1094/phyto-09-17-0332-r.

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Xanthomonas oryzae pv. oryzicola is an X. oryzae pathovar that causes bacterial leaf streak in rice. In this study, we performed functional characterization of a nine-gene his operon in X. oryzae pv. oryzicola. Sequence analysis indicates that this operon is highly conserved in Xanthomonas spp. Auxotrophic assays confirmed that the his operon was involved in histidine biosynthesis. We found that two genes within this operon, trpR and hisB, were required for virulence and bacterial growth in planta. Further research revealed that trpR and hisB play different roles in X. oryzae pv. oryzicola. Th

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7

Arvidson, D. N., M. Shapiro, and P. Youderian. "Mutant tryptophan aporepressors with altered specificities of corepressor recognition." Genetics 128, no. 1 (1991): 29–35. http://dx.doi.org/10.1093/genetics/128.1.29.

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Abstract The Escherichia coli trpR gene encodes tryptophan aporepressor, which binds the corepressor ligand, L-tryptophan, to form an active repressor complex. The side chain of residue valine 58 of Trp aporepressor sits at the bottom of the corepressor (L-tryptophan) binding pocket. Mutant trpR genes encoding changes of Val58 to the other 19 naturally occurring amino acids were made. Each of the mutant proteins requires a higher intracellular concentration of tryptophan for activation of DNA binding than wild-type aporepressor. Whereas wild-type aporepressor is activated better by 5-methyltry

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8

Tripet, Brian P., Anupam Goel, and Valérie Copié. "Internal Dynamics of the Tryptophan Repressor (TrpR) and Two Functionally Distinct TrpR Variants, L75F-TrpR and A77V-TrpR, in Theirl-Trp-Bound Forms." Biochemistry 50, no. 23 (2011): 5140–53. http://dx.doi.org/10.1021/bi200389k.

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9

Copie, Valerie, Brian Tripet, Anupam Goel, Lucas Nerbert, and Jannette Carey. "Dynamical Studies Of A Temperature-Sensitive Mutant Of The Tryptophan Repressor Protein, L75F-TrpR." Biophysical Journal 96, no. 3 (2009): 322a. http://dx.doi.org/10.1016/j.bpj.2008.12.1618.

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10

Grove, C. L., and R. P. Gunsalus. "Regulation of the aroH operon of Escherichia coli by the tryptophan repressor." Journal of Bacteriology 169, no. 5 (1987): 2158–64. http://dx.doi.org/10.1128/jb.169.5.2158-2164.1987.

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11

Goel, Anupam, Brian P. Tripet, Robert C. Tyler, Lucas D. Nebert, and Valérie Copié. "Backbone Amide Dynamics Studies of Apo-L75F-TrpR, a Temperature-Sensitive Mutant of the Tryptophan Repressor Protein (TrpR): Comparison with the15N NMR Relaxation Profiles of Wild-Type and A77V Mutant Apo-TrpR Repressors." Biochemistry 49, no. 37 (2010): 8006–19. http://dx.doi.org/10.1021/bi100508u.

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12

Tyler, Robert, István Pelczer, Jannette Carey, and Valérie Copié. "Three-Dimensional Solution NMR Structure of Apo-L75F-TrpR, a Temperature-Sensitive Mutant of the Tryptophan Repressor Protein†." Biochemistry 41, no. 40 (2002): 11954–62. http://dx.doi.org/10.1021/bi020304t.

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13

Sprenger, Janina, Jannette Carey, Alexander Schulz, et al. "Guest-protein incorporation into solvent channels of a protein host crystal (hostal)." Acta Crystallographica Section D Structural Biology 77, no. 4 (2021): 471–85. http://dx.doi.org/10.1107/s2059798321001078.

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Soaking small molecules into the solvent channels of protein crystals is the most common method of obtaining crystalline complexes with ligands such as substrates or inhibitors. The solvent channels of some protein crystals are large enough to allow the incorporation of macromolecules, but soaking of protein guests into protein crystals has not been reported. Such protein host crystals (here given the name hostals) incorporating guest proteins may be useful for a wide range of applications in biotechnology, for example as cargo systems or for diffraction studies analogous to the crystal sponge

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14

Walter, Tatjana, Kareen H. Veldmann, Susanne Götker, et al. "Physiological Response of Corynebacterium glutamicum to Indole." Microorganisms 8, no. 12 (2020): 1945. http://dx.doi.org/10.3390/microorganisms8121945.

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The aromatic heterocyclic compound indole is widely spread in nature. Due to its floral odor indole finds application in dairy, flavor, and fragrance products. Indole is an inter- and intracellular signaling molecule influencing cell division, sporulation, or virulence in some bacteria that synthesize it from tryptophan by tryptophanase. Corynebacterium glutamicum that is used for the industrial production of amino acids including tryptophan lacks tryptophanase. To test if indole is metabolized by C. glutamicum or has a regulatory role, the physiological response to indole by this bacterium wa

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15

Patridge, Eric V., and James G. Ferry. "WrbA from Escherichia coli and Archaeoglobus fulgidus Is an NAD(P)H:Quinone Oxidoreductase." Journal of Bacteriology 188, no. 10 (2006): 3498–506. http://dx.doi.org/10.1128/jb.188.10.3498-3506.2006.

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ABSTRACT WrbA (tryptophan [W] repressor-binding protein) was discovered in Escherichia coli, where it was proposed to play a role in regulation of the tryptophan operon; however, this has been put in question, leaving the function unknown. Here we report a phylogenetic analysis of 30 sequences which indicated that WrbA is the prototype of a distinct family of flavoproteins which exists in a diversity of cell types across all three domains of life and includes documented NAD(P)H:quinone oxidoreductases (NQOs) from the Fungi and Viridiplantae kingdoms. Biochemical characterization of the prototy

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16

Pokorzynski, Nick D., Nathan D. Hatch, Scot P. Ouellette, and Rey A. Carabeo. "The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis." Nature Communications 11, no. 1 (2020). http://dx.doi.org/10.1038/s41467-020-20181-5.

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AbstractThe trp operon of Chlamydia trachomatis is organized differently from other model bacteria. It contains trpR, an intergenic region (IGR), and the biosynthetic trpB and trpA open-reading frames. TrpR is a tryptophan-dependent repressor that regulates the major promoter (PtrpR), while the IGR harbors an alternative promoter (PtrpBA) and an operator sequence for the iron-dependent repressor YtgR to regulate trpBA expression. Here, we report that YtgR repression at PtrpBA is also dependent on tryptophan by regulating YtgR levels through a rare triple-tryptophan motif (WWW) in the YtgCR pre

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17

Sherchand, Shardulendra P., and Ashok Aiyar. "Ammonia generation by tryptophan synthase drives a key genetic difference between genital and ocular Chlamydia trachomatis isolates." May 3, 2019. https://doi.org/10.5281/zenodo.2662318.

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18

Melior, Hendrik, Sandra Maaß, Siqi Li, et al. "The Leader Peptide peTrpL Forms Antibiotic-Containing Ribonucleoprotein Complexes for Posttranscriptional Regulation of Multiresistance Genes." mBio 11, no. 3 (2020). http://dx.doi.org/10.1128/mbio.01027-20.

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ABSTRACT Bacterial ribosome-dependent attenuators are widespread posttranscriptional regulators. They harbor small upstream open reading frames (uORFs) encoding leader peptides, for which no functions in trans are known yet. In the plant symbiont Sinorhizobium meliloti, the tryptophan biosynthesis gene trpE(G) is preceded by the uORF trpL and is regulated by transcription attenuation according to tryptophan availability. However, trpLE(G) transcription is initiated independently of the tryptophan level in S. meliloti, thereby ensuring a largely tryptophan-independent production of the leader p

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19

Zuchowski, Rico, Simone Schito, Christina Mack, et al. "ALE reveals a surprising link between [Fe-S] cluster formation, tryptophan biosynthesis and the potential regulatory protein TrpP in Corynebacterium glutamicum." BMC Microbiology 25, no. 1 (2025). https://doi.org/10.1186/s12866-025-03939-z.

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Abstract Background The establishment of synthetic microbial communities comprising complementary auxotrophic strains requires efficient transport processes for common goods. With external supplementation of the required metabolite, most auxotrophic strains reach wild-type level growth. One exception was the l-trypton auxotrophic strain phaCorynebacterium glutamicum ΔTRP ΔtrpP, which grew 35% slower than the wild type in supplemented defined media. C. glutamicum ΔTRP ΔtrpP lacks the whole l-tryptophan biosynthesis cluster (TRP, cg3359-cg3364) as well as the putative l-tryptophan transporter Tr

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20

Wang, Li, YingLan Hou, HongXia Yuan, and Hongliang Chen. "The role of tryptophan in Chlamydia trachomatis persistence." Frontiers in Cellular and Infection Microbiology 12 (August 2, 2022). http://dx.doi.org/10.3389/fcimb.2022.931653.

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Chlamydia trachomatis (C. trachomatis) is the most common etiological agent of bacterial sexually transmitted infections (STIs) and a worldwide public health issue. The natural course with C. trachomatis infection varies widely between individuals. Some infections clear spontaneously, others can last for several months or some individuals can become reinfected, leading to severe pathological damage. Importantly, the underlying mechanisms of C. trachomatis infection are not fully understood. C. trachomatis has the ability to adapt to immune response and persist within host epithelial cells. Ind

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21

Xu, Zhizhou, Guichun Wu, Bo Wang, Yancun Zhao, and Fengquan Liu. "TrpR-like protein PXO_00831, regulated by the sigma factor RpoD, is involved in motility, oxidative stress tolerance, and virulence in Xanthomonas oryzae pv. oryzae." Phytopathology®, September 12, 2022. http://dx.doi.org/10.1094/phyto-05-22-0165-r.

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Xanthomonas oryzae pv. oryzae (Xoo) is a Gram-negative bacterium that causes bacterial leaf blight in rice. In this study, we identified a putative TrpR-like protein PXO_TrpR (PXO_00831) in Xoo. This protein contains a tryptophan (Trp) repressor domain and is highly conserved in Xanthomonas. Auxotrophic assays and RT–qPCR confirmed that PXO_TrpR acts as a Trp repressor, negatively regulating the expression of Trp biosynthesis genes. Pathogenicity tests showed that PXO_trpR knockout in Xoo significantly reduced lesion development and disease symptoms in the leaves of susceptible rice. RNA-seq a

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22

Mondal, Smarajit, Alexander V. Yakhnin, and Paul Babitzke. "Modular Organization of the NusA- and NusG-Stimulated RNA Polymerase Pause Signal That Participates in the Bacillus subtilis trp Operon Attenuation Mechanism." Journal of Bacteriology 199, no. 14 (2017). http://dx.doi.org/10.1128/jb.00223-17.

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ABSTRACT The Bacillus subtilis trpEDCFBA operon is regulated by a transcription attenuation mechanism in which tryptophan-activated TRAP binds to the nascent transcript and blocks the formation of an antiterminator structure such that the formation of an overlapping intrinsic terminator causes termination in the 5′ untranslated region (5′ UTR). In the absence of bound TRAP, the antiterminator forms and transcription continues into the trp genes. RNA polymerase pauses at positions U107 and U144 in the 5′ UTR. The general transcription elongation factors NusA and NusG stimulate pausing at both p

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23

Bommana, Sankhya, Naraporn Somboonna, Gracie Richards, Maryam Tarazkar, and Deborah Dean. "Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function." mBio, May 11, 2021. http://dx.doi.org/10.1128/mbio.00605-21.

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Chlamydia trachomatis ( Ct ) is a major global public health concern causing sexually transmitted and ocular infections affecting over 130 million and 260 million people, respectively. Sequelae include infertility, preterm birth, ectopic pregnancy, and blindness. Ct relies on available host tryptophan pools and/or substrates to synthesize tryptophan to survive.

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24

Sarkar, Jagannath. "Genomics of Brevibacterium strains reveal adaptations necessary to acclimatize in different marine environments." June 7, 2024. https://doi.org/10.5281/zenodo.13624149.

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<strong>ABSTRACT</strong> Microbes are ubiquitous throughout the seawater and underlying sediment, which covers the vast region of the earth surface. Strains of different genera under the phylum <em>Actinobacteria</em> are ubiquitous all-over different environments of the earth surfaces. A well-studied aerobic genus, <em>Brevibacterium</em>, under the phylum also found to be omnipresent in both marine and terrestrial environments, ranging from coastal to open ocean. Which raise question, whether marine strains are phylogenetically distinct from others or not, and what are the special genomic a

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